CN107374583A - One kind eliminates pseudo- image method and storage medium and imaging system in OCT blood vessel imagings - Google Patents
One kind eliminates pseudo- image method and storage medium and imaging system in OCT blood vessel imagings Download PDFInfo
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Abstract
The method that the present invention provides artifact in a kind of elimination OCT blood vessel imagings, including the collection of step OCT interference signals, OCT signal transactings, phase and intensity image generation, phase variance image calculation, intensity cross correlation image resolve, the shadow that disappears processing；The invention further relates to a kind of computer-readable recording medium, storage medium is stored for performing such as a kind of computer program of pseudo- image method in elimination OCT blood vessel imagings；The invention further relates to a kind of imaging system of artifact in elimination OCT blood vessel imagings；The present invention is on the premise of no increase imaging device complexity, experimental procedure and data collection capacity, make full use of the phase information and strength information that OCT interference signals are included, different variation characteristics is had based on the phase variance and intensity cross-correlation in artifact noise region, realizes the purpose for eliminating artifact noise in OCT blood vessel imagings.
Description
Technical field
The present invention relates to pseudo- image method in a kind of image processing method, more particularly to a kind of elimination OCT blood vessel imagings and answer
With the computer-readable recording medium and its imaging system of its method.
Background technology
OCT is that optical coherence tomography is a kind of Noninvasive and high-resolution imaging technique, clinically
It is used widely；Wherein, the most successfully application is ophthalmology to OCT, as the eye examination methods of standard.
Traditional OCT equipment is mainly structure imaging.In recent years, it is notable with the resolution ratio and image taking speed of OCT technology
Improve, new functional imaging is developed, the blood vessel imaging of most important application among this.Earliest OCT blood vessel imagings are more
General Le OCT, similar to doppler ultrasound, using doppler phenomenon of the light in blood flow, detect VPV.But due in biology
In the OCT image for organizing such as human eye, light beam and the doppler angle that blood flow is formed are too small, cause Doppler signal very faint,
So as to limit popularization of the technology in clinic.
In recent years, with the further development of OCT technology, people have invented new OCT Angiographies.These technologies
It is unrelated with Doppler signal, substantially increase the sensitivity of detection capilary.There is the technology of three class main flows at present：Based on phase,
Based on intensity, or the above two combination.Although above-mentioned blood vessel imaging method can provide very abundant blood vessel image information,
Artifact noise can not be all avoided, i.e. the direction of OCT signals is that axially depth, OCT phases caused by big blood vessel and intensity become
Change the phase and Strength Changes for causing occur falseness below, result is that occur false blood in OCT image below big blood vessel
When flowing the choroidal artery below signal, such as analysis retina, blood vessel artifact easily causes the erroneous judgement of clinical diagnosis, so anxious
Need a kind of method for eliminating artifact in blood vessel imaging.
The content of the invention
For overcome the deficiencies in the prior art, it is an object of the invention to provide one kind to eliminate artifact in OCT blood vessel imagings
Method and storage medium and imaging system,.
The present invention provides pseudo- image method in a kind of elimination OCT blood vessel imagings, comprises the following steps：
OCT interference signals gather, in some groups of OCT interference signals of identical Sample Scan station acquisition；
OCT signal transactings, signal transacting is carried out to some groups of OCT interference signals, obtains some groups of phase image
With intensity image；
Phase variance image calculation, variance calculating is carried out the respective pixel described some groups of phase image, obtained
Phase variance image；
Intensity cross correlation image is resolved, and cross correlation score is carried out the corresponding sub-region described some groups of intensity image
Calculate, obtain intensity cross correlation image；
The shadow that disappears processing, with reference to described phase variance image and described intensity cross correlation image with artifact region
The signal of described phase variance image carries out attenuation processing.
Further, the acquisition mode in described OCT interference signals collection is specially between the times such as identical B-scan position
Every collection.
Further, described OCT signal transactings include background removal, k- space interpolations, numerical dispersion compensation, frequency spectrum modeling
Shape, null-fill, Fourier transformation.
Further, described attenuation processing is specially that the power for combining phase variance image and intensity cross correlation image enters
Row image is multiplied, the signal of phase variance image in artifact region of decaying.
The present invention also provides a kind of computer-readable recording medium, and it stores the computer journey for electronic data interchange
Sequence, wherein, the computer program causes computer to perform the side as described in pseudo- image method in a kind of elimination OCT blood vessel imagings
Method.
The present invention also provides artifact imaging system in a kind of elimination OCT blood vessel imagings；Including light source, spectrometer, sample arm,
Reference arm, spectrometer and output module；Described spectrometer by wide band light caused by light source input respectively described sample arm and
Described reference arm；Described sample arm carries out the two-dimensional scan of light beam to biological tissue；Described in described reference arm matching
Dispersion in sample arm；The spectrometer convergence described in light beam warp being reflected back from described sample arm and described reference arm, is obtained
To OCT interference signals, described OCT interference signals are by described spectrometer collection；Described OCT interference signals are transmitted to described
Output module, described output module by computer OCT algorithm routines by OCT interference signals decoding disappear shadow generate OCT blood
Pipe image.
Further, described sample arm includes scanning galvanometer, scanning lens and aspherical ophthalmology mirror.
Further, described reference arm includes dispersion compensation module and speculum.
Compared with prior art, the beneficial effects of the present invention are：
The present invention provides pseudo- image method in a kind of elimination OCT blood vessel imagings, including the collection of step OCT interference signals, OCT letters
Number processing, phase and intensity image generation, phase variance image calculation, intensity cross correlation image are resolved, the shadow that disappears is handled；The present invention
A kind of computer-readable recording medium is further related to, storage medium stores eliminates artifact in OCT blood vessel imagings for performing as a kind of
The computer program of method；The invention further relates to one kind to eliminate artifact imaging system in OCT blood vessel imagings；The present invention is not increasing
On the premise of adding imaging device complexity, experimental procedure and data collection capacity, the phase that makes full use of OCT interference signals to be included
Information and strength information, different variation characteristics is had based on the phase variance and intensity cross-correlation in artifact noise region, it is real
Now eliminate the purpose of artifact noise in OCT blood vessel imagings.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of specification, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
The embodiment of the present invention is shown in detail by following examples and its accompanying drawing.
Brief description of the drawings
Accompanying drawing described herein is used for providing a further understanding of the present invention, forms the part of the application, this hair
Bright schematic description and description is used to explain the present invention, does not form inappropriate limitation of the present invention.In the accompanying drawings：
Fig. 1 is that a kind of of the present invention eliminates artifact method flow schematic diagram in OCT blood vessel imagings；
Fig. 2 is that a kind of of the present invention eliminates pseudo- image method imaging system institutional framework schematic diagram in OCT blood vessel imagings；
Fig. 3 is that artifact method and step schematic diagram in OCT blood vessel imagings is eliminated in one embodiment of the invention；
Fig. 4 is the effect pair that pseudo- image method applies in human body fundus imaging in a kind of elimination OCT blood vessel imagings of the invention
Compare schematic diagram.
Embodiment
Below, with reference to accompanying drawing and embodiment, the present invention is described further, it is necessary to which explanation is, not
Under the premise of afoul, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
The present invention provides artifact imaging system in a kind of elimination OCT blood vessel imagings；As shown in Fig. 2 including light source, light splitting
Meter, sample arm, reference arm, spectrometer and output module；Wide band light caused by light source is distinguished input sample arm and ginseng by spectrometer
Examine arm；Sample arm carries out the two-dimensional scan of light beam to biological tissue；Dispersion in reference arm matching sample arm；From sample arm and ginseng
Examine the light beam that arm is reflected back to converge through spectrometer, obtain OCT interference signals, OCT interference signals are by spectrometer collection；OCT interferes
Signal is transmitted to output module, and OCT interference signals are decoded the shadow that disappears by computer OCT algorithm routines and generate OCT by output module
Blood-vessel image.
In one embodiment, as shown in Fig. 2 wide band light caused by light source is distinguished input sample arm and ginseng by spectrometer
Arm is examined, sample arm includes scanning galvanometer, scanning lens and aspherical ophthalmology mirror, and the two of light beam is carried out to biological tissue's such as human eye
Dimension scanning, sample arm light path be light beam successively after scanned galvanometer, scanning lens and the rearmounted people's eye reflex of aspherical ophthalmology mirror again
It is back to successively through aspherical ophthalmology mirror, scanning lens, scanning galvanometer in spectrometer；Reference arm is comprising dispersion compensation module and instead
Mirror is penetrated, for matching the dispersion in sample arm, reference arm light path is light beam dispersion compensating module and speculum Hou Yuan road successively
It is back to spectrometer.The light being transmitted back to from sample arm and reference arm converges through spectrometer, OCT interference signals is produced, by spectrometer
Detection collection；OCT interference signals are transmitted to the image capture interface of output module, and image capture interface is hardware interface or software
Interface, OCT interference signals are transmitted to computer, computer-internal and is provided with OCT algorithm routines and OCT interference signals is decoded into the shadow that disappears
Generate OCT blood-vessel images.
The present invention also provides a kind of computer-readable recording medium, and it stores the computer journey for electronic data interchange
Sequence, wherein, computer program causes computer to perform such as method in pseudo- image method in a kind of elimination OCT blood vessel imagings.
One kind eliminates pseudo- image method in OCT blood vessel imagings, as shown in Figure 1, Figure 3, comprises the following steps：
OCT interference signals gather, in some groups of OCT interference signals of identical Sample Scan station acquisition, in identical sample
Product B-scan station acquisition N group OCT interference signals, constant duration between N group signals；Next B-scan position is moved to, again
N group OCT interference signals are gathered, so repeatedly, until the scanning area all standing scanning for completing to pre-set, wherein, B-scan is
By a plurality of detection information handled by briliancy side by side be combined into it is two-dimentional, reflect tomography section inside testee
The scan mode of " anatomic image ".
OCT signal transactings, as shown in figure 3, signal transacting is carried out to some groups of OCT interference signals, specifically, OCT signals
Processing includes background removal, k- space interpolations, numerical dispersion compensates, frequency spectrum is moulding, null-fill, Fourier transformation, if obtaining
The phase image and intensity image of dry group.
Phase variance image calculation, variance calculating is carried out the respective pixel some groups of phase image, obtains phase
Variance image；Intensity cross correlation image is resolved, and cross correlation score meter is carried out the corresponding sub-region some groups of intensity image
Calculate, obtain intensity cross correlation image；Compared to intensity cross correlation image, because phase place change is more sensitive, phase variance image
Blood vessel Effect on Detecting it is more satisfactory.Because OCT phases and Strength Changes caused by big blood vessel cause occur falseness below
Phase and Strength Changes, cause occur false blood flow signal, i.e. blood vessel artifact noise in these images below big blood vessel.
The shadow that disappears processing, with reference to phase variance image and intensity cross correlation image with to phase variance image in artifact region
Signal carry out attenuation processing.Specifically, the letter of phase variance image and intensity cross correlation image in blood vessel artifact noise region
Number strong and weak different, phase variance signal is higher, and intensity cross-correlated signal is relatively low, and attenuation processing is specially to combine phase variance image
Image is carried out with the power of intensity cross correlation image to be multiplied, the signal of phase variance image, reaches elimination in artifact region of decaying
The effect of artifact noise.It is multiplied it should be appreciated that phase variance image carries out image with the power of intensity cross correlation image to cut down
Phase variance signal in artifact region, when specific algorithm is realized, its successive ignition can be multiplied, and corresponding iterations setting pair
The algorithm answered overflows threshold value, and phase variance is less than in current iteration number when overflowing threshold value, then attenuation processing stops, and now thinks
Artifact noise substantially eliminates, as shown in figure 4, for one in human body fundus imaging using the present invention it is a kind of eliminate OCT blood vessels into
The Major Vessels artifact eradicating efficacy schematic diagram of pseudo- image method as in, artifact eradicating efficacy is obvious in figure.
The present invention provides pseudo- image method in a kind of elimination OCT blood vessel imagings, including the collection of step OCT interference signals, OCT letters
Number processing, phase and intensity image generation, phase variance image calculation, intensity cross correlation image are resolved, the shadow that disappears is handled；The present invention
A kind of computer-readable recording medium is further related to, storage medium stores eliminates artifact in OCT blood vessel imagings for performing as a kind of
The computer program of method；The invention further relates to one kind to eliminate artifact imaging system in OCT blood vessel imagings；The present invention is not increasing
On the premise of adding imaging device complexity, experimental procedure and data collection capacity, the phase that makes full use of OCT interference signals to be included
Information and strength information, different variation characteristics is had based on the phase variance and intensity cross-correlation in artifact noise region, it is real
Now eliminate the purpose of artifact noise in OCT blood vessel imagings.
More than, only presently preferred embodiments of the present invention, any formal limitation not is made to the present invention；All one's own professions
The those of ordinary skill of industry can swimmingly implement the present invention shown in by specification accompanying drawing and above；But all to be familiar with sheet special
The technical staff of industry without departing from the scope of the present invention, is made a little using disclosed above technology contents
The equivalent variations of variation, modification and evolution, it is the equivalent embodiment of the present invention；Meanwhile all substantial technologicals according to the present invention
Variation, modification and evolution of any equivalent variations made to above example etc., still fall within technical scheme
Within protection domain.
Claims (8)
1. one kind eliminates pseudo- image method in OCT blood vessel imagings, it is characterised in that comprises the following steps：
OCT interference signals gather, in some groups of OCT interference signals of identical Sample Scan station acquisition；
OCT signal transactings, signal transacting is carried out to some groups of OCT interference signals, obtain some groups of phase image with it is strong
Spend image；
Phase variance image calculation, variance calculating is carried out the respective pixel described some groups of phase image, obtains phase
Variance image；
Intensity cross correlation image is resolved, and cross correlation score meter is carried out the corresponding sub-region described some groups of intensity image
Calculate, obtain intensity cross correlation image；
The shadow that disappears processing, with reference to described phase variance image and described intensity cross correlation image, to described in artifact region
The signal of phase variance image carries out attenuation processing.
2. pseudo- image method in a kind of elimination OCT blood vessel imagings as claimed in claim 1, it is characterised in that：Described OCT interference
Acquisition mode in signal acquisition is specially the constant duration collection of identical B-scan position.
3. pseudo- image method in a kind of elimination OCT blood vessel imagings as claimed in claim 1, it is characterised in that：Described OCT signals
Processing includes background removal, k- space interpolations, numerical dispersion compensates, frequency spectrum is moulding, null-fill, Fourier transformation.
4. pseudo- image method in a kind of elimination OCT blood vessel imagings as claimed in claim 1, it is characterised in that：At described decay
Reason is specially to combine phase variance image to be multiplied with the power progress image of intensity cross correlation image, phase in artifact region of decaying
The signal of variance image.
5. a kind of computer-readable recording medium, it stores the computer program for electronic data interchange, wherein, the calculating
Machine program causes computer to perform the method as described in claim 1.
6. one kind eliminates artifact imaging system in OCT blood vessel imagings, it is characterised in that：Including light source, spectrometer, sample arm, ginseng
Examine arm, spectrometer and output module；Wide band light caused by light source is inputted described sample arm and institute by described spectrometer respectively
The reference arm stated；Described sample arm carries out the two-dimensional scan of light beam to biological tissue；The described sample of described reference arm matching
Dispersion in product arm；The spectrometer convergence described in light beam warp being reflected back from described sample arm and described reference arm, is obtained
OCT interference signals, described OCT interference signals are by described spectrometer collection；Described OCT interference signals are transmitted to described
OCT interference signals are decoded the shadow that disappears by computer OCT algorithm routines and generate OCT blood vessels by output module, described output module
Image.
7. artifact imaging system in a kind of elimination OCT blood vessel imagings as claimed in claim 6, it is characterised in that：Described sample
Product arm includes scanning galvanometer, scanning lens and aspherical ophthalmology mirror.
8. artifact imaging system in a kind of elimination OCT blood vessel imagings as claimed in claim 6, it is characterised in that：Described ginseng
Examining arm includes dispersion compensation module and speculum.
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| CN112330764A (en) * | 2020-11-03 | 2021-02-05 | 华北电力大学（保定） | Biological endoscopic photoacoustic image reconstruction method and system for compensating acoustic reflection |
| CN113017593A (en) * | 2021-02-23 | 2021-06-25 | 浙江大学 | Blood vessel tail artifact removing method and system based on blood flow signal intensity layered filtering |
| CN113643396A (en) * | 2021-08-05 | 2021-11-12 | 中国科学院苏州生物医学工程技术研究所 | Method and device for processing frequency sweep OCT image |
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| CN115830170A (en) * | 2023-02-13 | 2023-03-21 | 天津恒宇医疗科技有限公司 | Method and system for removing scanning endoscopic OCT image artifacts based on phase information |
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| CN116725492A (en) * | 2023-07-11 | 2023-09-12 | 江苏金视传奇科技有限公司 | Blood vessel imaging method and system based on optical coherence tomography |
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