CN107373273A - Adult type multivitamin mineral effervescent tablet and preparation method thereof - Google Patents
Adult type multivitamin mineral effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN107373273A CN107373273A CN201710590675.XA CN201710590675A CN107373273A CN 107373273 A CN107373273 A CN 107373273A CN 201710590675 A CN201710590675 A CN 201710590675A CN 107373273 A CN107373273 A CN 107373273A
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- parts
- vitamin
- effervescent tablet
- adult type
- acid
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- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 64
- 239000011707 mineral Substances 0.000 title claims abstract description 64
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 66
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 63
- 235000010755 mineral Nutrition 0.000 claims abstract description 63
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 62
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 60
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 54
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229960000304 folic acid Drugs 0.000 claims abstract description 33
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- 239000011724 folic acid Substances 0.000 claims abstract description 33
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 31
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 31
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims abstract description 31
- 239000001527 calcium lactate Substances 0.000 claims abstract description 31
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- 235000011086 calcium lactate Nutrition 0.000 claims abstract description 31
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000011718 vitamin C Substances 0.000 claims abstract description 31
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 22
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- 239000003795 chemical substances by application Substances 0.000 claims description 55
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- 239000008187 granular material Substances 0.000 claims description 28
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- 235000003599 food sweetener Nutrition 0.000 claims description 21
- 239000003765 sweetening agent Substances 0.000 claims description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 18
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 18
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a kind of adult type multivitamin mineral effervescent tablet and preparation method thereof, is related to health product technology field, including following component according to the mass fraction：28,000 30000 parts of calcium carbonate, 53,000 55000 parts of calcium lactate, 660 700 parts of zinc oxide, 1,500 1600 parts of vitamin E, 195 215 parts of vitamin A, 6,000 6200 parts of vitamin C, 4,500 4600 parts of ferrous gluconate, vitamin B160 80 parts, vitamin B260 80 parts, vitamin B660 80 parts, 10 15 parts of folic acid, vitamin B1210 15 parts, 24 parts of sodium selenite；240,000 260000 parts of auxiliary material, alleviate the single technical problem of curative effect of medicine on the market, reach and multivitamin and mineral matter are provided, meet that busy personage takes in the effect of balanced nutritious needs.
Description
Technical field
The present invention relates to health product technology field, more particularly, to a kind of adult type multivitamin mineral effervescent tablet and
Its preparation method.
Background technology
With the quickening pace of modern life with the increase of life stress, the life of people is more and more busier, especially commercial people
For scholar, it is necessary to often go on business, diet is very irregular, often eats and drinks immoderately, or even breakfast skipping, causes the diet nutritional of intake uneven
, the immunity degradation of body, there is tired mind, decrease of memory, or even can induce hypertension, high fat of blood and cardiovascular and cerebrovascular in weighing apparatus
Etc. disease.
The existing medicament of replenishing vitamins on the market is mostly vitamin C and vitamin E, and curative effect is single, can not meet busy
Personage's general equilibrium supplements the needs of multivitamin and mineral matter.
In view of this, it is special to propose the present invention.
The content of the invention
An object of the present invention is to provide a kind of adult type multivitamin mineral effervescent tablet, to alleviate existing city
The medicament of replenishing vitamins is mostly vitamin C and vitamin E on face, and curative effect is single, can not meet busy personage's general equilibrium
Supplement the technical problem that multivitamin and mineral matter need.
Adult type multivitamin mineral effervescent tablet provided by the invention, including following component according to the mass fraction：
Major ingredient：Calcium carbonate 28000-30000 parts, calcium lactate 53000-55000 parts, zinc oxide 660-700 parts, vitamin E 1500-
1600 parts, vitamin A 195-215 parts, vitamin C 6000-6200 parts, ferrous gluconate 4500-4600 parts, vitamin
B160-80 parts, vitamin B260-80 parts, vitamin B660-80 parts, folic acid 10-15 parts, vitamin B1210-15 parts, sodium selenite
2-4 parts；Auxiliary material：Sour agent 135000-140000 parts, alkaline agent 100000-110000 parts, adhesive 50-70 parts, filler 3500-
3700 parts, 5100 parts -5200 parts of sweetener.
Further, the adult type multivitamin mineral effervescent tablet includes following component according to the mass fraction：
Calcium carbonate 28500-29500 parts, calcium lactate 53500-54500 parts, zinc oxide 675-695 parts, vitamin E 1520-1570 parts,
Vitamin A 200-210 parts, vitamin C 6050-6150 parts, ferrous gluconate 4540-4560 parts, vitamin B165-75
Part, vitamin B265-75 parts, vitamin B665-75 parts, folic acid 11-13 parts, vitamin B1211-13 parts, sodium selenite 2-4 parts；
Auxiliary material：Sour agent 135000-140000 parts, alkaline agent 100000-110000 parts, adhesive 50-70 parts, filler 3500-3700 parts,
Sweetener 5100-5200 parts.
Further, the auxiliary material also includes essence 1600-1800 parts according to the mass fraction.
Further, the sweetener is selected from least one of Sucralose, lactose and xylitol, it is preferred that described
Sweetener is the mixture of lactose and Sucralose, and both mass ratioes are (9-10)：1.
Further, the sour agent in tartaric acid, malic acid, fumaric acid, citric acid or sodium citrate at least one
Kind；Preferably, the sour agent is citric acid.
Further, the alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate and calcium bicarbonate
At least one of；Preferably, the alkaline agent is sodium acid carbonate.
Further, the filler is selected from maltodextrin and/or water soluble starch, preferably maltodextrin；It is described viscous
Mixture is PVP K30.
The second object of the present invention is the provision of the preparation method of above-mentioned adult type multivitamin mineral effervescent tablet,
Mostly it is vitamin C and vitamin E to alleviate the medicament of existing replenishing vitamins on the market, curative effect is single, can not meet busy
Personage's general equilibrium supplements the technical problem that multivitamin and mineral matter need.
The preparation method of adult type multivitamin mineral effervescent tablet provided by the invention, comprises the following steps：
(a) by vitamin A, folic acid, vitamin C, vitamin E, filler, sour agent, sweetener, adhesive and optional perfume (or spice)
Essence is well mixed, and by wet granulation and drying, the first granule is made；
(b) by vitamin B1, vitamin B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose is ferrous, carbon
Sour calcium, calcium lactate, alkaline agent and adhesive are well mixed, and by wet granulation and drying, the second granule is made；
(c) the first granule and the second granule are well mixed, carry out tabletting, that is, adult type multivitamin ore deposit is made
Material effervescent tablet.
Further, the preparation method of above-mentioned adult type multivitamin mineral effervescent tablet also includes step (s), described
Step (s) is arranged at before the step (a), and the step (s) is by vitamin A, folic acid, vitamin C, vitamin B1, dimension
Raw plain B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose ferrous iron, calcium lactate, calcium carbonate, vitamin E, fill out
Fill agent, sour agent, alkaline agent, sweetener and optional essence to be crushed, and cross 80 mesh sieves.
Further, during the first granule and the second granule carry out wet granulation, used wetting agent
It is ethanol.
Adult type multivitamin mineral effervescent tablet provided by the invention, pass through calcium carbonate, calcium lactate, zinc oxide, dimension
Raw plain E, vitamin A, vitamin C, ferrous gluconate, vitamin B1, vitamin B2, vitamin B6, folic acid, vitamin B12, it is sub-
The coordinated of sodium selenate, multivitamin and mineral matter can not only be provided, meet that busy personage takes in general equilibrium nutrition
Needs, and body immunity can be strengthened, improve memory, anti-aging, while can also in water fater disintegration, clothes
It is rapid with conveniently, working, it is easy to carry with and drinks.
The preparation method of adult type multivitamin mineral effervescent tablet provided by the invention, technique is simple, easy to operate,
It is easy to carry out big industrial production, reduces and prepare cost, improves preparation efficiency.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the invention provides a kind of adult type multivitamin mineral effervescent tablet, bag
Include following component according to the mass fraction：Major ingredient：Calcium carbonate 28000-30000 parts, calcium lactate 53000-55000 parts, zinc oxide
660-700 parts, vitamin E 1500-1600 parts, vitamin A 195-215 parts, vitamin C 6000-6200 parts, gluconic acid
Ferrous 4500-4600 parts, vitamin B160-80 parts, vitamin B260-80 parts, vitamin B660-80 parts, folic acid 10-15
Part, vitamin B1210-15 parts, sodium selenite 2-4 parts；Auxiliary material：Sour agent 135000-140000 parts, alkaline agent 100000-110000
Part, adhesive 50-70 parts, filler 3500-3700 parts, 5100 parts -5200 parts of sweetener.
Adult type multivitamin mineral effervescent tablet provided by the invention, pass through calcium carbonate, calcium lactate, zinc oxide, dimension
Raw plain E, vitamin A, vitamin C, ferrous gluconate, vitamin B1, vitamin B2, vitamin B6, folic acid, vitamin B12, it is sub-
The coordinated of sodium selenate, multivitamin and mineral matter can not only be provided, meet that busy personage takes in general equilibrium nutrition
Needs, and body immunity can be strengthened, improve memory, anti-aging, while can also in water fater disintegration, clothes
It is rapid with conveniently, working, it is easy to carry with and drinks.
In the present invention, the typical but non-limiting mass fraction of calcium carbonate as 28100,28200,28300,
28400、28500、28600、28700、28800、28900、29000、29100、29200、29300、29400、29500、
29600th, 29700,29800 or 29900 parts.
Calcium carbonate can effectively supplement the calcium content of body, and help to prevent and treat osteoporosis.
In the present invention, the typical but non-limiting mass fraction of calcium lactate be 53100,53200,53300,53400,
53500、53600、53700、53800、53900、54000、54100、54200、54300、54400、54500、54600、
54700th, 54800 or 54900 parts.
Calcium lactate has the characteristics of solubility is high, dissolution velocity is fast, bioavailability is high, in good taste, can effectively supplement
The calcium constituent of human body.
In the present invention, calcium carbonate and calcium lactate coordinated, absorption of the human body to calcium is more beneficial for, effect of supplemented calcium is more
It is good.
In the present invention, the typical but non-limiting mass fraction of zinc oxide as 662,664,666,668,670,
672nd, 674,676,678,680,682,684,686,688,690,692,694,696 or 698 parts.
Zinc oxide not only has the function that to draw out pus by applying a plaster to the affected part, stopped blooding, promoting regeneration of tissue for astringency, can also promote intelligence development.
The typical but non-limiting mass fraction of vitamin E as 1505,1510,1515,1520,1525,1530,
1535th, 1540,1545,1550,1555,1560,1565,1570,1575,1580,1585,1590 or 1595 parts.
Vitamin E is a kind of liposoluble vitamin, also known as tocopherol, is one of most important antioxidant, can promote to swash
Element secretion, make man's sperm motility and quantity increase, increase woman's estrogen concentrations, improve fecundity.
The typical but non-limiting mass fraction of vitamin A as 196,197,198,199,200,201,202,203,
204th, 205,206,207,208,209,210,211,212,213 or 214 parts.
Vitamin A is fat-soluble alcohols material, be form cellula visualis in experience dim light rhodopsin composition into
Point.It can adjust the effect of epidermis and cuticula metabolism, can be removed wrinkle with anti-aging, protected mucous membrane not invaded by bacterium
Evil, healthy skin, prevent cutaneum carcinoma, prevent yctalopia, the blurring of image, treat various eye illnesses, promote the pre- preventing obesity of bone growth
With preventing and treating alopecia.
Ascorbic typical but non-limiting mass fraction as 6010,6020,6030,6040,6050,6060,
6070th, 6080,6090,6100,6110,6120,6130,6140,6150,6160,6170,6180 or 6190.
Vitamin C is called L-AA, is a kind of water soluble vitamin, and it has anti-oxidant, raising immunity, prevention
Cancer, heart disease, apoplexy, take care of one's teeth with gum etc..In addition, adhere to that taking vitamin C can also make dermal melanin calm
Reduce, so as to reduce blackspot and freckle, make whitening skin.
The typical but non-limiting mass fraction of ferrous gluconate as 4505,4510,4515,4520,4525,
4530th, 4535,4540,4545,4550,4555,4560,4565,4570,4575,4580,4585,4590 or 4595 parts.
Ferrous gluconate by reducible iron and gluconic acid form, be characterized in bioavailability height, it is molten in water
Good, the gentle no astringent taste of flavor of solution property, while anaemia can be treated.
Vitamin B1Typical but non-limiting mass fraction as 61,62,63,64,65,66,67,68,69,70,
71st, 72,73,74,75,76,77,78 or 79 parts.
Vitamin B1It is mainly used in treating " athlete's foot ", peripheral neuritis and indigestion, hyperthyroidism, burns
Wound, long-term chronic infection, heavy physical labour, malabsorption syndrome is with disease in the liver and gallbladder.
Vitamin B2Typical but non-limiting mass fraction as 61,62,63,64,65,66,67,68,69,70,
71st, 72,73,74,75,76,77,78 or 79 parts.
Vitamin B2Riboflavin is called, is slightly soluble in water, is the part of internal yellow enzymes prothetic group, major physiological functions is
Coenzyme promotes metabolism, and it can promote development and the regeneration of cell, promote the normal growth of skin, nail, hair, help to prevent
With elimination oral cavity reproductive syndrome, promote eyesight, mitigate the fatigue of eyes, promote energetic supersession.
Vitamin B6Typical but non-limiting mass fraction as 61,62,63,64,65,66,67,68,69,70,
71st, 72,73,74,75,76,77,78 or 79 parts.
Vitamin B6It is the necessary material of body fat and glycometabolism, artery sclerosis can be treated, cholesterol is too high, low blood
Sugared disease, phrenoblabia, muscle dysfunction, neurological disorder and overweight etc..
The typical but non-limiting mass fraction of folic acid as 10.2,10.4,10.6,10.8,11,11.2,11.4,
11.6th, 11.8,12,12.2,12.4,12.6,12.8,13,13.2,13.4,13.6,13.8,14,14.2,14.4,14.6 or
14.8。
Folic acid is a kind of water soluble vitamin, plays the role of to promote juvenile cell maturation, the mankind in marrow such as to lack folic acid, can
Cause macrocytic anemia and leukopenia, it is particularly important to pregnant woman.Folic acid to the merisis and nucleic acid of cell,
The synthesis of amino acid, protein plays an important role.
Vitamin B12Typical but non-limiting mass fraction as 10.2,10.4,10.6,10.8,11,11.2,
11.4、11.6、11.8、12、12.2、12.4、12.6、12.8、13、13.2、13.4、13.6、13.8、14、14.2、14.4、
14.6 or 14.8.
Vitamin B12It is a kind of B family vitamin being made up of the porphyrins containing cobalt, the hair of red blood cell can be promoted
Educate and ripe, body hematopoiesis technical ability is in normal condition, prevent pernicious anaemia, nervous system health is safeguarded, with the shape of coenzyme
Formula is present, and can increase the utilization rate of folic acid, promotes carbohydrate, fat and protein metabolism, active amino acid
Effect and the biosynthesis for promoting nucleic acid, can promote the synthesis of protein, eliminate and have the fidgets, focus on, enhancing memory
And the sense of equilibrium.
In the present invention, the typical but non-limiting mass fraction of sodium selenite as 2.1,2.2,2.3,2.4,2.5,
2.6th, 2.7,2.8,2.9,3,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8 or 3.9.
Sodium selenite is used to supplement selenium element, and selenium is the part of glutathione peroxidase, is tieed up by oxidation
The function of cell membrane is held, improves the yield of the endogenous antioxidant of the esters property of protein, participates in the conversion of energy, is influenceed
Metabolism, emulsification, absorption and multivitamin absorption to fat play an important role.
In the present invention, the typical but non-limiting mass fraction of sour agent as 135500,136000,136500,
137000th, 137500,138000,138500,139000 or 139500 parts.
In a preferred embodiment of the invention, sour agent is selected from tartaric acid, malic acid, fumaric acid, citric acid or citric acid
At least one of sodium, it is preferred that sour agent is citric acid.
When sour agent is citric acid, obtained adult type multivitamin mineral effervescent tablet disintegration speed faster,
Solution after dissolving is also more clarified.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of alkaline agent as 100500,
101000、101500、102000、102500、103000、103500、104000、104500、105000、105500、106000、
106500th, 107000,107500,108000,108500,109000 or 109500 parts.
In a preferred embodiment of the invention, alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, bicarbonate
At least one of sodium and calcium bicarbonate, it is preferred that the alkaline agent is sodium acid carbonate.
When alkaline agent is sodium acid carbonate, the adult type multivitamin mineral effervescent tablet disintegration rate obtained by it is more
It hurry up, the solution after dissolving is also more clarified.
In the present invention, the typical but non-limiting mass fraction of adhesive as 51,52,53,54,55,56,57,
58th, 59,60,61,62,63,64,65,66,67,68 or 69.
In a preferred embodiment of the invention, adhesive is PVP K30.
In the present invention, the typical but non-limiting mass fraction of filler as 3510,3520,3530,3540,
3550th, 3560,3570,3580,3590,3600,3610,3620,3630,3640,3650,3660,3670,3680 or 3690.
In a preferred embodiment of the invention, filler is selected from maltodextrin and/or water soluble starch, preferably malt
Dextrin.
In the present invention, the typical but non-limiting mass fraction of sweetener as 5115,5120,5125,5130,
5135th, 5140,5145,5150,5155,5160,5165,5170,5175,5180,5185,5190 or 5195.
In a preferred embodiment of the invention, sweetener is selected from least one of Sucralose, lactose and xylitol；
Preferably, the sweetener is the mixture of lactose and Sucralose, and both mass ratioes are (9-10)：1.
When the mixture that sweetener is lactose and Sucralose, and both mass ratioes are (9-10):When 1, obtained by it
Adult type multivitamin mineral effervescent tablet mouthfeel it is more preferable.
In a preferred embodiment of the invention, auxiliary material also includes essence 1600-1800 parts according to the mass fraction.
In a preferred embodiment of the invention, the typical but non-limiting mass fraction of essence as 16100,
16200、16300、16400、16500、16600、16700、16800、16900、17000、17100、17200、17300、
17400th, 17500,17600,17700,17800 or 17900 parts.
By add essence with improve the present invention adult type multivitamin mineral effervescent tablet mouthfeel, make its more by
Consumer welcomes.
In the present invention, essence can be the essence of the various tastes such as fruity, milk taste.
According to another aspect of the present invention, present invention also offers above-mentioned adult type multivitamin mineral effervescent tablet
Preparation method, comprise the following steps：
(a) by vitamin A, folic acid, vitamin C, vitamin E, filler, sour agent, sweetener adhesive and optional perfume (or spice)
Essence is well mixed, and by wet granulation and drying, the first granule is made；
(b) by vitamin B1, vitamin B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose is ferrous, carbon
Sour calcium, calcium lactate, alkaline agent and adhesive are well mixed, and by wet granulation and drying, the second granule is made；
(c) the first granule and the second granule are well mixed, carry out tabletting, that is, adult type multivitamin ore deposit is made
Material effervescent tablet.
The preparation method of adult type multivitamin mineral effervescent tablet provided by the invention, technique is simple, easy to operate,
It is easy to carry out big industrial production, reduces and prepare cost, improves preparation efficiency.
In a preferred embodiment of the invention, the preparation method of adult type multivitamin mineral effervescent tablet also includes
Following steps (s), the step (s) are arranged at before the step (a), and the step (s) is to give birth to vitamin A, folic acid, dimension
Plain C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose ferrous iron, calcium lactate, carbonic acid
Calcium, vitamin E, filler, sour agent, alkaline agent, sweetener and optional essence are crushed, and cross 80 mesh sieves.
By by vitamin A, folic acid, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, selenous acid
Sodium, zinc oxide, glucose ferrous iron, calcium lactate, vitamin E, filler, sour agent, alkaline agent, sweetener and optional essence are carried out
Crush, and cross 80 mesh sieves, in order to which above-mentioned substance is easier to be well mixed, so as to be adult type multivitamin mineral matter effervesce
The stability of drug effect provides guarantee between each tablet of piece.
In a preferred embodiment of the invention, the process of wet granulation is carried out in the first granule and the second granule
In, used wetting agent is ethanol, and preferably PVP K30 is dissolved in ethanol, then is mixed with other raw materials,
Carry out wet granulation；Preferably, the concentration of the ethanol solution of PVP K30 is 5%.
In a preferred embodiment of the invention, it is that wetting agent carries out wet granulation by using ethanol solution, in order to
Can be at low temperature quickly by ethanol evaporation during follow-up dry.
In a preferred embodiment of the invention, in step (a) and step (b), dry temperature is 45-50 DEG C, excellent
Elect 50 DEG C as.
By the way that drying temperature is controlled at 45-50 DEG C, by ethanol evaporation, while ensure the drug effect of each raw material, and avoid shape
It is phenomena such as into caking, more preferable to the drying effect of the first granule and the second granule especially when drying temperature is 50 DEG C,
Drying efficiency is higher.
In a preferred embodiment of the invention, the preparation method of adult type multivitamin mineral effervescent tablet, according to
Following steps are carried out：
(s) by vitamin A, folic acid, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, selenous acid
Sodium, zinc oxide, glucose ferrous iron, calcium carbonate, calcium lactate, vitamin E, filler, sour agent, alkaline agent, sweetener and optional perfume (or spice)
Essence is crushed, and crosses 80 mesh sieves；
(a) by vitamin A and folic acid by equal increments method it is well mixed after, then with vitamin C, vitamin E, filling
Agent, sweetener and optional essence are well mixed, then are well mixed with sour agent, are then added adhesive and are well mixed, and are carried out
Wet granulation, the first wet granular agent is made, 4-5h is dried in the first wet granular agent at 50 DEG C, and cross 18 mesh sieve whole grains
Afterwards, the first granule is obtained；
(b) first by vitamin B1, vitamin B2, vitamin B6It is well mixed, then vitamin B is added by equal increments method12
Be well mixed with sodium selenite, then by equal increments method add ferrous gluconate and zinc oxide it is well mixed after, add
Calcium lactate and calcium carbonate are well mixed, and are added alkaline agent and are well mixed, and the adhesive for then adding surplus is well mixed, and are carried out
Wet granulation, the second wet granular agent is made, 4-5h is dried in the second wet granular agent at 50 DEG C, and pass through 18 mesh sieve whole grains
Afterwards, the second granule is obtained；
(c) after mixing the first granule and the second granule 30 minutes, tabletting is carried out, that is, a variety of dimension lifes of adult type are made
Plain mineral effervescent tablet.
For the ease of understanding technical scheme provided by the invention, with reference to embodiment to technical scheme provided by the invention
It is further described.
Embodiment 1
A kind of adult type multivitamin mineral effervescent tablet is present embodiments provided, by following original according to the mass fraction
Material is prepared：Major ingredient：28000 parts of calcium carbonate, 55000 parts of calcium lactate, 660 parts of zinc oxide, 1600 parts of vitamin E, vitamin
195 parts of A, 6200 parts of vitamin C, 4500 parts of ferrous gluconate, vitamin B160 parts, vitamin B280 parts, vitamin B6
60 parts, 15 parts of folic acid, vitamin B1210 parts, 4 parts of sodium selenite；Auxiliary material：135000 parts of citric acid, 107966 parts of sodium acid carbonate,
50 parts of PVP K30,3700 parts of maltodextrin, 4600 parts of lactose, 500 parts of Sucralose, 1800 parts of essence.
Embodiment 2
A kind of adult type multivitamin mineral effervescent tablet is present embodiments provided, by following original according to the mass fraction
Material is prepared：Major ingredient：30000 parts of calcium carbonate, 53000 parts of calcium lactate, 700 parts of zinc oxide, 1500 parts of vitamin E, vitamin
215 parts of A, 6000 parts of vitamin C, 4600 parts of ferrous gluconate, vitamin B180 parts, vitamin B260 parts, vitamin
B680 parts, 10 parts of folic acid, vitamin B1215 parts, 2 parts of sodium selenite；Auxiliary material：140000 parts of citric acid, sodium acid carbonate 103368
Part, 70 parts of PVP K30,3500 parts of maltodextrin, 4700 parts of lactose, 500 parts of Sucralose, 1600 parts of essence.
Embodiment 3
A kind of adult type multivitamin mineral effervescent tablet is present embodiments provided, by following original according to the mass fraction
Material is prepared：Major ingredient：28500 parts of calcium carbonate, 54500 parts of calcium lactate, 675 parts of zinc oxide, 1570 parts of vitamin E, vitamin
200 parts of A, 6150 parts of vitamin C, 4540 parts of ferrous gluconate, vitamin B175 parts, vitamin B265 parts, vitamin B6
75 parts, 11 parts of folic acid, vitamin B1213 parts, 2 parts of sodium selenite；Auxiliary material：138000 parts of citric acid, 105177 parts of sodium acid carbonate,
60 parts of PVP K30,3600 parts of maltodextrin, 4660 parts of lactose, 497 parts of Sucralose, 1700 parts of essence.
Embodiment 4
A kind of adult type multivitamin mineral effervescent tablet is present embodiments provided, by following original according to the mass fraction
Material is prepared：Major ingredient：29500 parts of calcium carbonate, 53500 parts of calcium lactate, 695 parts of zinc oxide, 1520 parts of vitamin E, vitamin
210 parts of A, 6050 parts of vitamin C, 4560 parts of ferrous gluconate, vitamin B165 parts, vitamin B275 parts, vitamin B6
65 parts, 13 parts of folic acid, vitamin B1211 parts, 4 parts of sodium selenite；Auxiliary material：135000 parts of citric acid, 108663 parts of sodium acid carbonate,
60 parts of PVP K30,3600 parts of maltodextrin, 4660 parts of lactose, 497 parts of Sucralose, 1700 parts of essence.
Embodiment 5
A kind of adult type multivitamin mineral effervescent tablet is present embodiments provided, by the raw material of following mass fraction meter
It is prepared：Major ingredient：29000 parts of calcium carbonate, 54000 parts of calcium lactate, 680 parts of zinc oxide, 1550 parts of vitamin E, vitamin A
206 parts, 6100 parts of vitamin C, 4550 parts of ferrous gluconate, vitamin B170 parts, vitamin B270 parts, vitamin B6
70 parts, 12 parts of folic acid, vitamin B1212 parts, 3 parts of sodium selenite；Auxiliary material：138000 parts of citric acid, 105160 parts of sodium acid carbonate,
3600 parts of maltodextrin, 60 parts of PVP K30,4660 parts of lactose, 497 parts of Sucralose, 1700 parts of essence.
The preparation method for the adult type multivitamin mineral effervescent tablet that embodiment 1-5 is provided, enters in accordance with the following steps
OK：
(s) will be by vitamin A, folic acid, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, selenous acid
Sodium, zinc oxide, glucose ferrous iron, calcium lactate, vitamin E, maltodextrin, citric acid, sodium acid carbonate, lactose, Sucralose and
Essence is respectively crushed, and crosses 80 mesh sieves；PVP K30 is dissolved in ethanol solution, the poly- dimension that concentration is 5% is made
Ketone ethanol solution；
(a) by vitamin A and folic acid by equal increments method it is well mixed after, then paste with vitamin C, vitamin E, malt
Essence, lactose, Sucralose and essence are well mixed, then are well mixed with citric acid, then add the PVP that concentration is 5%
Solution is well mixed, and carries out wet granulation, and the first wet granular agent is made, the first wet granular agent is dried into 4- at 50 DEG C
5h, after making ethanol solution evaporating completely, 18 mesh sieve whole grains are crossed, obtain the first granule；
(b) first vitamin B1, vitamin B2, vitamin B6 are well mixed, then vitamin is added by equal increments method
B12 and sodium selenite are well mixed, then by equal increments method add ferrous gluconate and zinc oxide it is well mixed after, then add
Enter calcium lactate and calcium carbonate be well mixed, add sodium acid carbonate and be well mixed, the concentration for then adding surplus be 5% it is poly-
It is well mixed to tie up ketone solution, carries out wet granulation, the second wet granular agent is made, by the second wet granular agent at 50 DEG C
4-5h is dried, after making ethanol solution evaporating completely, crosses 18 mesh sieve whole grains, obtains the second granule；
(c) after mixing the first granule and the second granule 30 minutes, tabletting is carried out, that is, a variety of dimension lifes of adult type are made
Plain mineral effervescent tablet.
Comparative example 1
This comparative example provides a kind of adult type multivitamin mineral effervescent tablet, by following original according to the mass fraction
Material is prepared：Major ingredient：20000 parts of calcium carbonate, 60000 parts of calcium lactate, 800 parts of zinc oxide, 2000 parts of vitamin E, vitamin
250 parts of A, 5000 parts of vitamin C, 5000 parts of ferrous gluconate, vitamin B1100 parts, vitamin B250 parts, vitamin
B6100 parts, 20 parts of folic acid, vitamin B125 parts, 1 part of sodium selenite；Auxiliary material：150000 parts of citric acid, sodium acid carbonate 96274
Part, 30 parts of PVP K30,3000 parts of maltodextrin, 5000 parts of lactose, 400 parts of Sucralose, 2000 parts of essence.
Comparative example 2
This comparative example provides a kind of adult type multivitamin mineral effervescent tablet, by following original according to the mass fraction
Material is prepared：Major ingredient：40000 parts of calcium carbonate, 45000 parts of calcium lactate, 600 parts of zinc oxide, 1200 parts of vitamin E, vitamin
150 parts of A, 7000 parts of vitamin C, 4000 parts of ferrous gluconate, vitamin B150 parts, vitamin B2100 parts, vitamin
B650 parts, 5 parts of folic acid, vitamin B1220 parts, 5 parts of sodium selenite；Auxiliary material：121520 parts of citric acid, sodium acid carbonate 120000
Part, 100 parts of PVP K30,4000 parts of maltodextrin, 4500 parts of lactose, 800 parts of Sucralose, 1000 parts of essence.
The preparation method for the adult type multivitamin mineral effervescent tablet that comparative example 1-2 is provided is with embodiment 5, herein
Repeat no more.
Above-described embodiment 1-5 is related to the adult type multivitamin mineral effervescent tablet progress that comparative example 1-2 is provided
The detection of performance, testing result are as shown in the table：
The adult type multivitamin mineral effervescent tablet performance detection table of table 1
It can be seen from Table 1 that the adult type multivitamin mineral effervescent tablet piece shape that 1-5 of the embodiment of the present invention is provided
Good, without glutinous punching, solution is clarified after dissolving, and pH value is between 4.1-4.2, and disintegration is rapid, disintegration time 92-94s, at 3 months
Time in weight and taste keep being basically unchanged, stability is good.
By embodiment 1-5 and comparative example 1-2 contrast, work as calcium carbonate, calcium lactate, zinc oxide, vitamin E, dimension
Raw plain A, vitamin C, ferrous gluconate, vitamin B1, vitamin B2, vitamin B6, folic acid, vitamin B12, sodium selenite exists
When in the range of specific mass fraction, each raw material coordinated, obtained adult type multivitamin mineral effervescent tablet piece
Shape is good, and without glutinous punching, solution is clarified after dissolving, allows drinking person more to trust.
In addition, the adult type multivitamin mineral effervescent tablet that is provided of embodiment 1-5 and comparative example 1-2 January,
2 months and March microbioassay has been carried out respectively, do not find the presence of microorganism.
In order to verify that the adult type multivitamin mineral effervescent tablet that embodiment 1-5 and comparative example 1-2 is provided is faced
Bed experiment, employee 400 people of certain Business Consultation company reflection with battle-weary, failure of memory symptom is chosen, the age is
35-45 year, it is divided into 8 groups, every group of 50 people, respectively A-H groups, wherein, A-E groups take the adult type of embodiment 1-5 offers respectively
Multivitamin mineral effervescent tablet, F-G groups take the adult type multivitamin mineral matter effervesce of comparative example 1-2 offers respectively
Piece, H groups are blank control group, and A-G groups take 2 adult type multivitamin mineral effervescent tablets for each person every day, every 3.5g,
H groups take placebo, and statistics is tracked after one month, and its result is as shown in the table：
The adult type multivitamin mineral effervescent tablet clinical detection table of table 2
In the effect of the present embodiment counts, effectively to feel in high spirits, body and mind is comfortable, energetic, and memory increases
By force；Effective to be made moderate progress for mental status, sleep quality lifting, memory has strengthened, invalid not change for mental status,
Feel exhausted, failure of memory.
The contrast of A-E groups and H groups is as can be seen that person takes a variety of dimension lifes of adult type of the present embodiment 1-5 offers from table 2
Employee after plain mineral effervescent tablet, its effective number and efficiently individual quantity are real obviously higher than blank control group, this explanation present invention
Balanced nutritious, fatigue-relieving can effectively be supplemented by applying the adult type multivitamin mineral effervescent tablet that a 1-5 is provided, and promote body
Heart health and raising memory.
The contrast of A-E groups and F-G groups, which can be seen that, from table 2 works as calcium carbonate, calcium lactate, zinc oxide, vitamin E, dimension life
Plain A, vitamin C, ferrous gluconate, vitamin B1, vitamin B2, vitamin B6, folic acid, vitamin B12, sodium selenite is in spy
When in the range of fixed mass fraction, each raw material coordinated, obtained adult type multivitamin mineral effervescent tablet is slow
Faster, validity is higher for action in terms of solution fatigue, promotion physical and mental health and raising memory.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of adult type multivitamin mineral effervescent tablet, it is characterised in that including following component according to the mass fraction：
Major ingredient：Calcium carbonate 28000-30000 parts, calcium lactate 53000-55000 parts, zinc oxide 660-700 parts, vitamin E 1500-
1600 parts, vitamin A 195-215 parts, vitamin C 6000-6200 parts, ferrous gluconate 4500-4600 parts, vitamin B1
60-80 parts, vitamin B260-80 parts, vitamin B660-80 parts, folic acid 10-15 parts, vitamin B1210-15 parts, selenous acid
Sodium 2-4 parts；Auxiliary material：Sour agent 135000-140000 parts, alkaline agent 100000-110000 parts, adhesive 50-70 parts, filler
3500-3700 parts, 5100 parts -5200 parts of sweetener.
2. adult type multivitamin mineral effervescent tablet according to claim 1, it is characterised in that including by mass parts
The following component of number meter：Calcium carbonate 28500-29500 parts, calcium lactate 53500-54500 parts, zinc oxide 675-695 parts, vitamin
E 1520-1570 parts, vitamin A 200-210 parts, vitamin C 6050-6150 parts, ferrous gluconate 4540-4560 parts,
Vitamin B165-75 parts, vitamin B265-75 parts, vitamin B665-75 parts, folic acid 11-13 parts, vitamin B12 11-13
Part, sodium selenite 2-4 parts；Auxiliary material：Sour agent 135000-140000 parts, alkaline agent 100000-110000 parts, adhesive 50-70 parts,
Filler 3500-3700 parts, sweetener 5100-5200 parts.
3. adult type multivitamin mineral effervescent tablet according to claim 1 or 2, it is characterised in that auxiliary material also wraps
Include essence 1600-1800 parts according to the mass fraction.
4. adult type multivitamin mineral effervescent tablet according to claim 1 or 2, it is characterised in that the sweet taste
Agent is selected from least one of Sucralose, lactose and xylitol；Preferably, the sweetener is the mixed of lactose and Sucralose
Compound, and both mass ratioes are (9-10)：1.
5. adult type multivitamin mineral effervescent tablet according to claim 1 or 2, it is characterised in that the sour agent
Selected from least one of tartaric acid, malic acid, fumaric acid, citric acid or sodium citrate；Preferably, the sour agent is lemon
Acid.
6. adult type multivitamin mineral effervescent tablet according to claim 1 or 2, it is characterised in that the alkaline agent
Selected from least one of potassium carbonate, sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate and calcium bicarbonate；Preferably, it is described
Alkaline agent is sodium acid carbonate.
7. adult type multivitamin mineral effervescent tablet according to claim 1 or 2, it is characterised in that the filling
Agent is selected from maltodextrin and/or water soluble starch, preferably maltodextrin；Described adhesive is PVP K30.
8. the preparation method of the adult type multivitamin mineral effervescent tablet according to claim any one of 1-7, it is special
Sign is, comprises the following steps：
(a) vitamin A, folic acid, vitamin C, vitamin E, filler, sour agent, sweetener, adhesive and optional essence are mixed
Close uniformly, by wet granulation and drying, the first granule is made；
(b) by vitamin B1, vitamin B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose is ferrous, carbonic acid
Calcium, calcium lactate, alkaline agent and adhesive are well mixed, and by wet granulation and drying, the second granule is made；
(c) the first granule and the second granule are well mixed, carry out tabletting, that is, adult type multivitamin mineral matter is made
Effervescent tablet.
9. the preparation method of adult type multivitamin mineral effervescent tablet according to claim 7, it is characterised in that also
Including step (s), the step (s) is arranged at before the step (a), and the step (s) is to give birth to vitamin A, folic acid, dimension
Plain C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, sodium selenite, zinc oxide, glucose ferrous iron, calcium lactate, carbonic acid
Calcium, vitamin E, filler, sour agent, alkaline agent, sweetener and optional essence are crushed, and cross 80 mesh sieves.
10. the preparation method of adult type multivitamin mineral effervescent tablet according to claim 8, it is characterised in that
During the first granule and the second granule carry out wet granulation, used wetting agent is ethanol.
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| CN111972589A (en) * | 2020-08-24 | 2020-11-24 | 中盐工程技术研究院有限公司 | Dunaliella salina powder effervescent tablet for supplementing vitamin A |
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Address after: No.1302, No.7, Dongqing street, high tech Industrial Development Zone, Zhengzhou City, Henan Province 450001 Applicant after: Bokai Pharmaceutical Co., Ltd Address before: 450000 No. 5 Acacia Street, hi tech Development Zone, Henan, Zhengzhou Applicant before: Zhengzhou Bokai Medicine &. Health-Care Products Co., Ltd. |
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