CN107353191A - A kind of method for extracting Physcion - Google Patents
A kind of method for extracting Physcion Download PDFInfo
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- CN107353191A CN107353191A CN201710598788.4A CN201710598788A CN107353191A CN 107353191 A CN107353191 A CN 107353191A CN 201710598788 A CN201710598788 A CN 201710598788A CN 107353191 A CN107353191 A CN 107353191A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
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Abstract
The invention provides a kind of method for extracting Physcion, the medicinal material containing Physcion is extracted using ethanol water, obtained material is centrifuged, obtains extract solution and the dregs of a decoction, obtained extract solution is concentrated, obtains Physcion.The present invention handles the material obtained after extraction by the way of centrifugation, it is possible to increase production efficiency, running cost is reduced, suitable for industrialized production.
Description
Technical field
The present invention relates to medicine extractive technique field, and in particular to a kind of method for extracting Physcion.
Background technology
Physcion is the hydroxy anthraquinones chemical combination being widely present in a variety of dicotyledons especially polygonaceae plant
Thing, chemical name are Physcion, have a variety of physiologically actives, such as to Staphylococcus aureus
26 kinds of bacteriums such as bacterium, Escherichia coli, Pseudomonas aeruginosa, streptococcus and shigella dysenteriae have inhibitory action, in salmonella TA1535
There is mutation effect in experiment, it is stronger to the long-living inhibitory action of Human Cervical Hela cells etc..
In actual production technique, extract Physcion the step of mainly include feed intake, extract, filtering, concentrating 4 ranks
Section.The mode that the decompression of filtration stage generally use filters in the prior art, but this method operating time is long, solvent volatilizing loss
Amount is big, causes low production efficiency, running cost high.
The content of the invention
It is an object of the invention to provide a kind of method for extracting Physcion, and production efficiency is high, running cost is low, fits
In industrialized production.
The invention provides a kind of method for extracting Physcion, comprise the following steps：
(1) medicinal material containing Physcion is extracted using ethanol water；
(2) material that the step (1) obtains is centrifuged, obtains extract solution and the dregs of a decoction；
(3) extract solution that the step (2) obtains is concentrated, obtains Physcion.
Preferably, stir speed (S.S.) is extracted in the step (1) to be carried out under conditions of 50~70r/min.
Preferably, the weight/mass percentage composition of ethanol water is 40%~90% in the step (1).
Preferably, the number of extraction is 3~4 times in the step (1).
Preferably, the time extracted every time is independently selected from 20~70min.
Preferably, the centrifugation rate centrifuged in the step (2) is 7000~8000r/min.
Preferably, the time centrifuged in the step (2) is 3~15min.
Preferably, concentration is 5%~15% that extract solution is concentrated into the extract solution original volume in the step (3).
Preferably, the temperature of concentration is 45~55 DEG C in the step (3).
Preferably, the vacuum of concentration is 0.65~0.8MPa in the step (3).
The invention provides a kind of method for extracting Physcion, using ethanol water to containing Physcion
Medicinal material is extracted, and obtained material is centrifuged, obtains extract solution and the dregs of a decoction, obtained extract solution is carried out dense
Contracting, obtains Physcion.The mode that generally use decompression filters in the prior art handles the material obtained after extraction, is in institute
State one end outside material system and give a negative pressure, according to this different characteristic of the granule size of material, stopped using screen cloth big
The material of particle is by allowing other end of atmospheric pressure that filtrate is pressed through into filter cloth, so as to reach the effect of separation；This method operates
Time is long, solvent volatilizing loss amount is big, causes low production efficiency, running cost high.Present invention place by the way of centrifuging
Obtained material after reason extraction, is that a centrifugal force is given in the material system, according to the density of material it is of different sizes this
One characteristic, solid precipitation is set to realize separation of solid and liquid to liquid phase bottom；Method provided by the invention can improve production efficiency, drop
Lower operational cost, suitable for industrialized production.Meanwhile the extract obtained using method provided by the invention need not carry out it is other after
Processing, according to being actually needed, it can be diluted compounding packaging directly as female medicine by adding other medicaments, produce commercially available
Drug products.
Embodiment
The invention provides a kind of method for extracting Physcion, comprise the following steps：
(1) medicinal material containing Physcion is extracted using ethanol water；
(2) material that the step (1) obtains is centrifuged, obtains extract solution and the dregs of a decoction；
(3) extract solution that the step (2) obtains is concentrated, obtains Physcion.
The present invention is extracted using ethanol water to the medicinal material containing Physcion.The present invention contains for described
The species of the medicinal material of Physcion does not have special restriction, using Physcion content well known to those skilled in the art compared with
High medicinal material, such as rheum officinale or giant knotweed.The present invention preferably first crushes to the medicinal material containing Physcion, then enters
Row subsequent extracted.The present invention crushes no special restriction for described, using the skill of crushing well known to those skilled in the art
Art scheme.The present invention is preferably crushed the medicinal material containing Physcion, is crossed 100~120 mesh sieves, is sieved
Lower part carries out subsequent extracted.
In the present invention, the weight/mass percentage composition of ethanol water is preferably 40%~90% during the extraction, more preferably
For 50%~80%, most preferably 60%~70%.In the present invention, the mass ratio of the ethanol water and medicinal material is preferably
(1~6)：1, more preferably (2~5)：1, be most preferably (3~4)：1.In the present invention, the extraction is preferably in stir speed (S.S.)
To be carried out under conditions of 50~70r/min, more preferably 55~65r/min.In the present invention, the temperature of the extraction is preferably
20~65 DEG C, more preferably 25~60 DEG C, most preferably 30~55 DEG C.In the present invention, the number of the extraction be preferably 3~
4 times.In the present invention, the time extracted every time is preferably independently 20~70min, more preferably 30~60min, is most preferably
40~50min.
After completing the extraction, obtained material is centrifuged the present invention, obtains extract solution and the dregs of a decoction.In this hair
In bright, the centrifugation rate of the centrifugation is preferably 7000~8000r/min, more preferably 7300~7700r/min；It is described
The time of centrifugation is preferably 3~15min, more preferably 5~10min.Used by the present invention is for the centrifugation
Equipment does not have special restriction, using the equipment well known to those skilled in the art for being used to centrifuge.The present invention's
In embodiment, can specifically DHC400 butterfly centrifugals machine be used to carry out the centrifugation during actual production, rotary drum rotating speed be
7056r/min, equivalent depositional area are 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw.
After completing the centrifugation, the present invention is concentrated obtained extract solution, obtains Physcion.In this hair
In bright, extract solution is preferably concentrated into the 5%~15% of the extract solution original volume by the concentration, more preferably 9%~
12%.In the present invention, the temperature of the concentration is preferably 45~55 DEG C, more preferably 48~52 DEG C；The vacuum of the concentration
Degree is preferably 0.65~0.8MPa, more preferably 0.7~0.75MPa.The present invention for the concentration used by equipment do not have
Special restriction, using the equipment well known to those skilled in the art for being used to concentrate.In an embodiment of the present invention, it is actual
Can specifically double-effect concentration evaporator be used to carry out the concentration during production, evaporation capacity 4t/h, consumption quantity of steam is 1.8t/h,
Circulation water consumption is 30t/h.
In the present invention, specifically, when the number of the extraction is 3 times, the method for the extraction Physcion is excellent
Choosing comprises the following steps：
(a) first time extraction is carried out to the medicinal material containing Physcion using ethanol water, resulting material is carried out
First centrifuges, and obtains extract solution I and dregs of a decoction I；
(b) carry out second to step (a) the Chinese medicine slag I using ethanol water to extract, the is carried out to resulting material
Two centrifuge, and obtain extract solution II and dregs of a decoction II；
(c) third time extraction is carried out to step (b) the Chinese medicine slag II using ethanol water, the is carried out to resulting material
Three centrifuge, and obtain extract solution III and dregs of a decoction III；
(d) extract solution III in extract solution II and step (c) is merged in the step (a) in extract solution I, step (b), it is right
The extract solution obtained after merging is concentrated, and obtains Physcion.
First time extraction is carried out to the medicinal material containing Physcion present invention preferably employs ethanol water, to gains
Material carries out first and centrifuged, and obtains extract solution I and dregs of a decoction I.In the present invention, it is water-soluble to carry out ethanol during the first time extraction
The weight/mass percentage composition of liquid is preferably 40%~90%, more preferably 70%~86%, most preferably 78%~82%.In this hair
In bright, when carrying out first time extraction ethanol water and the mass ratio of the medicinal material containing Physcion be preferably (4~
6)：1, concretely 4：1、5：1 or 6：1.In the present invention, the first time extraction is 50~70r/ preferably in stir speed (S.S.)
Carried out under conditions of min, more preferably 55~65r/min.In the present invention, the temperature of first time extraction be preferably 20~
30 DEG C, more preferably 23~27 DEG C；The time of the first time extraction is preferably 50~70min, more preferably 55~65min.
Resulting material carries out the first centrifugation, the described first centrifugation speed centrifuged after the present invention extracts to first time
Rate is preferably 7000~8000r/min, more preferably 7300~7700r/min；Described first time centrifuged was preferably 3
~15min, more preferably 5~10min.Equipment does not have special limit used by the present invention centrifuges for described first
It is fixed, using the equipment well known to those skilled in the art for being used to centrifuge.In an embodiment of the present invention, actual production
When can specifically use DHC400 butterfly centrifugals machine to carry out the centrifugation, rotary drum rotating speed is 7056r/min, equivalent depositional plane
Product is 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw.
After obtaining extract solution I and dregs of a decoction I, the dregs of a decoction I is carried for the second time present invention preferably employs ethanol water
Take, carrying out second to resulting material centrifuges, and obtains extract solution II and dregs of a decoction II.In the present invention, carry out described second
The weight/mass percentage composition of ethanol water is preferably 40%~90% during extraction, and more preferably 60%~80%, be most preferably
68%~72%.In the present invention, the mass ratio for carrying out described second ethanol water when extracting and dregs of a decoction I be preferably (2~
4)：1, concretely 2：1、3：1 or 4：1.In the present invention, second of extraction is 50~70r/ preferably in stir speed (S.S.)
Carried out under conditions of min, more preferably 55~65r/min.In the present invention, the temperature of second extraction be preferably 55~
65 DEG C, more preferably 58~62 DEG C；The time of second of extraction is preferably 50~70min, more preferably 55~65min.
Resulting material carries out the second centrifugation, the described second centrifugation speed centrifuged after the present invention extracts to second
Rate is preferably 7000~8000r/min, more preferably 7300~7700r/min；Described second time centrifuged was preferably 3
~15min, more preferably 5~10min.Equipment does not have special limit used by the present invention centrifuges for described second
It is fixed, using the equipment well known to those skilled in the art for being used to centrifuge.In an embodiment of the present invention, actual production
When can specifically use DHC400 butterfly centrifugals machine to carry out the centrifugation, rotary drum rotating speed is 7056r/min, equivalent depositional plane
Product is 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw.
After obtaining extract solution II and dregs of a decoction II, third time is carried out to the dregs of a decoction II present invention preferably employs ethanol water
Extraction, the 3rd is carried out to resulting material and is centrifuged, obtains extract solution III and dregs of a decoction III.In the present invention, described the is carried out
The weight/mass percentage composition of ethanol water is preferably 40%~90% when extracting three times, and more preferably 50%~70%, most preferably
For 58%~62%.In the present invention, the mass ratio of ethanol water and dregs of a decoction II is preferably when carrying out the third time extraction
(1~3)：1, concretely 1：1、2：1 or 3：1.In the present invention, third time extraction preferably stir speed (S.S.) be 50~
Carried out under conditions of 70r/min, more preferably 55~65r/min.In the present invention, the temperature of the third time extraction is preferably
55~65 DEG C, more preferably 58~62 DEG C；The time of the third time extraction is preferably 20~40min, more preferably 25~
35min。
Resulting material carries out the 3rd centrifugation, the described 3rd centrifugation speed centrifuged after the present invention extracts to third time
Rate is preferably 7000~8000r/min, more preferably 7300~7700r/min；Described 3rd time centrifuged was preferably 3
~15min, more preferably 5~10min.Equipment does not have special limit used by the present invention centrifuges for the described 3rd
It is fixed, using the equipment well known to those skilled in the art for being used to centrifuge.In an embodiment of the present invention, actual production
When can specifically use DHC400 butterfly centrifugals machine to carry out the centrifugation, rotary drum rotating speed is 7056r/min, equivalent depositional plane
Product is 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw.
After completing third time extraction, the present invention preferably merges the extract solution I, extract solution II and extract solution III, to merging
The extract solution obtained afterwards is concentrated, and obtains Physcion.In the present invention, extract solution is preferably concentrated into by the concentration
The 5%~15% of the extract solution original volume, more preferably 9%~12%.In the present invention, the temperature of the concentration is preferably
45~55 DEG C, more preferably 48~52 DEG C；The vacuum of the concentration is preferably 0.65~0.8MPa, more preferably 0.7~
0.75MPa.The present invention for the concentration used by equipment there is no a special restriction, use is well known to those skilled in the art
Equipment for concentration.In an embodiment of the present invention, can specifically be entered during actual production using double-effect concentration evaporator
The row concentration, evaporation capacity 4t/h, consumption quantity of steam is 1.8t/h, and circulation water consumption is 30t/h.
After completing the concentration, the present invention actually obtains Physcion extract, in the Physcion extract
In addition to containing Physcion, also containing other active components, such as Physcion, rheum emodin, Chrysophanol and Rhein.
In the present invention, the Physcion extract need not carry out other post processings, can be directly as female medicine, according to actual need
Will, compounding packaging is diluted by adding other medicaments, produces marketed drugs product.
Below in conjunction with the embodiment in the present invention, the technical scheme in the present invention is clearly and completely described.It is aobvious
So, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based on the reality in the present invention
Example is applied, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, is all belonged to
In the scope of protection of the invention.
Embodiment 1
(1) rheum officinale is crushed, crosses 120 mesh sieves, take lower part of screen to be allocated as medicinal material to be extracted；
(2) under conditions of stir speed (S.S.) is 60r/min, use 4 times of quality of medicinal material to be extracted, weight/mass percentage composition for
86% ethanol water carries out extraction 60min for the first time at 25 DEG C to medicinal material to be extracted in the step (1), in centrifugation speed
Rate carries out first to resulting material under conditions of being 7500r/min and centrifuges 5min, obtains extract solution I and dregs of a decoction I；
(3) under conditions of stir speed (S.S.) is 60r/min, 2 times of dregs of a decoction I mass, weight/mass percentage composition are used as 80%
Ethanol water carries out second of extraction 60min at 60 DEG C to the step (2) Chinese medicine slag I, is 7500r/ in centrifugation rate
Second is carried out to resulting material under conditions of min and centrifuges 12min, obtains extract solution II and dregs of a decoction II；
(4) under conditions of stir speed (S.S.) is 60r/min, 1 times of dregs of a decoction II mass, weight/mass percentage composition are used as 70%
Ethanol water carries out third time extraction 30min at 60 DEG C to the step (3) Chinese medicine slag II, is 7500r/ in centrifugation rate
The 3rd is carried out to resulting material under conditions of min and centrifuges 10min, obtains extract solution III and dregs of a decoction III；
(5) extract solution III in extract solution II and step (4) is merged in the step (2) in extract solution I, step (3), in
The extract solution original volume is concentrated into the extract solution obtained after merging under conditions of vacuum is 0.7MPa, temperature is 50 DEG C
15%, obtain Physcion.
Embodiment 2
(1) giant knotweed is crushed, crosses 100 mesh sieves, take lower part of screen to be allocated as medicinal material to be extracted；
(2) under conditions of stir speed (S.S.) is 70r/min, use 6 times of quality of medicinal material to be extracted, weight/mass percentage composition for
70% ethanol water carries out extraction 50min for the first time at 30 DEG C to medicinal material to be extracted in the step (1), in centrifugation speed
Rate carries out first to resulting material under conditions of being 8000r/min and centrifuges 3min, obtains extract solution I and dregs of a decoction I；
(3) under conditions of stir speed (S.S.) is 70r/min, 4 times of dregs of a decoction I mass, weight/mass percentage composition are used as 60%
Ethanol water carries out second of extraction 50min at 65 DEG C to the step (2) Chinese medicine slag I, is 8000r/ in centrifugation rate
Second is carried out to resulting material under conditions of min and centrifuges 15min, obtains extract solution II and dregs of a decoction II；
(4) under conditions of stir speed (S.S.) is 70r/min, 3 times of dregs of a decoction II mass, weight/mass percentage composition are used as 50%
Ethanol water carries out third time extraction 20min at 65 DEG C to the step (3) Chinese medicine slag II, is 8000r/ in centrifugation rate
The 3rd is carried out to resulting material under conditions of min and centrifuges 10min, obtains extract solution III and dregs of a decoction III；
(5) extract solution III in extract solution II and step (4) is merged in the step (2) in extract solution I, step (3), in
The extract solution original volume is concentrated into the extract solution obtained after merging under conditions of vacuum is 0.65MPa, temperature is 55 DEG C
5%, obtain Physcion.
Embodiment 3
(1) rheum officinale is crushed, crosses 120 mesh sieves, take lower part of screen to be allocated as medicinal material to be extracted；
(2) under conditions of stir speed (S.S.) is 50r/min, use 5 times of quality of medicinal material to be extracted, weight/mass percentage composition for
80% ethanol water carries out extraction 70min for the first time at 20 DEG C to medicinal material to be extracted in the step (1), in centrifugation speed
Rate carries out first to resulting material under conditions of being 7000r/min and centrifuges 8min, obtains extract solution I and dregs of a decoction I；
(3) under conditions of stir speed (S.S.) is 50r/min, 3 times of dregs of a decoction I mass, weight/mass percentage composition are used as 70%
Ethanol water carries out second of extraction 70min at 55 DEG C to the step (2) Chinese medicine slag I, is 7000r/ in centrifugation rate
Second is carried out to resulting material under conditions of min and centrifuges 8min, obtains extract solution II and dregs of a decoction II；
(4) under conditions of stir speed (S.S.) is 50r/min, 2 times of dregs of a decoction II mass, weight/mass percentage composition are used as 60%
Ethanol water carries out third time extraction 40min at 55 DEG C to the step (3) Chinese medicine slag II, is 7000r/ in centrifugation rate
The 3rd is carried out to resulting material under conditions of min and centrifuges 8min, obtains extract solution III and dregs of a decoction III；
(5) extract solution III in extract solution II and step (4) is merged in the step (2) in extract solution I, step (3), in
The extract solution original volume is concentrated into the extract solution obtained after merging under conditions of vacuum is 0.8MPa, temperature is 45 DEG C
10%, obtain Physcion.
Pilot extraction thing that embodiment 3 is prepared carries out chemical composition detection, and with each chemistry in rhubarb medicinal material into
The testing result of each chemical composition content is compared in testing result and existing literature the report rhubarb medicinal material of point content, is tied
Fruit is shown in Table 1.In table 1, each chemical composition content is in terms of g/100g in rhubarb medicinal material, i.e., each chemical composition in every 100g rhubarb medicinal materials
Quality (g)；For literature values equally in terms of g/100g, i.e. conversion is the quality per each chemical composition in 100g rhubarb medicinal materials
(g)；Each chemical composition content is equally in terms of g/100g in the present embodiment extract, i.e., corresponding conversion be using 100g rhubarb medicinal materials as
Medicinal material to be extracted, the quality (g) of each chemical composition is contained in obtained extract.
Each chemical composition content comparative result of table 1
Embodiment 4
Using giant knotweed as medicinal material to be extracted, according to the step of embodiment 3 and operating parameter is extracted, in being prepared
Try extract carry out chemical composition detection, and with the testing result of each chemical composition content in Rhizoma Polygoni Cuspidati and existing literature report
The testing result of each chemical composition content is compared in road Rhizoma Polygoni Cuspidati, the results are shown in Table 2.In table 2, each chemistry in Rhizoma Polygoni Cuspidati
Component content is in terms of g/100g, i.e., the quality (g) of each chemical composition in every 100g Rhizoma Polygoni Cuspidatis；Literature values are equally with g/
100g is counted, i.e. conversion is the quality (g) per each chemical composition in 100g Rhizoma Polygoni Cuspidatis；Each chemical composition in the present embodiment extract
For content equally in terms of g/100g, i.e., corresponding conversion is using 100g Rhizoma Polygoni Cuspidatis as medicinal material to be extracted, is contained in obtained extract
The quality (g) of each chemical composition.
Each chemical composition content comparative result of table 2
From Tables 1 and 2, technical scheme provided by the invention can fully be carried to Physcion in medicinal material
Take, while can realize and other active materials in medicinal material are fully extracted.
Embodiment 5
Technical scheme provided by the invention is applied in actual industrial production, specifically includes following steps：
(1) rheum officinale is crushed, crosses 120 mesh sieves, take lower part of screen to be allocated as medicinal material to be extracted；
(2) under conditions of stir speed (S.S.) is 60r/min, use 5 times of quality of medicinal material to be extracted, weight/mass percentage composition for
80% ethanol water carries out extraction 60min for the first time at 25 DEG C to medicinal material to be extracted in the step (1)；Using
DHC400 butterfly centrifugals machine carries out first to resulting material and centrifuged, and obtains extract solution I and dregs of a decoction I, wherein, rotary drum rotating speed is
7056r/min, equivalent depositional area are 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw；
(3) under conditions of stir speed (S.S.) is 60r/min, 3 times of dregs of a decoction I mass, weight/mass percentage composition are used as 70%
Ethanol water carries out second of extraction 60min at 60 DEG C to the step (2) Chinese medicine slag I；Using DHC400 butterfly centrifugals
Machine carries out second to resulting material and centrifuged, and obtains extract solution II and dregs of a decoction II, wherein, rotary drum rotating speed is 7056r/min, when
It is 28.5 × 10 to measure depositional area7cm2, handling capacity 5t/h, power of motor 7.5kw；
(4) under conditions of stir speed (S.S.) is 60r/min, 2 times of dregs of a decoction II mass, weight/mass percentage composition are used as 60%
Ethanol water carries out third time extraction 30min at 60 DEG C to the step (3) Chinese medicine slag II；Using DHC400 butterfly centrifugals
Machine carries out the 3rd to resulting material and centrifuged, and obtains extract solution III and dregs of a decoction III, wherein, rotary drum rotating speed is 7056r/min,
Equivalent depositional area is 28.5 × 107cm2, handling capacity 5t/h, power of motor 7.5kw；
(5) extract solution III in extract solution II and step (4) is merged in the step (2) in extract solution I, step (3), in
Under conditions of vacuum is 0.75MPa, temperature is 50 DEG C, the extract solution obtained after merging is concentrated using double-effect concentration evaporator
To the 10% of the extract solution original volume, wherein, evaporation capacity 4t/h, consumption quantity of steam is 1.8t/h, and circulation water consumption is
30t/h, obtain Physcion.
Reference examples 1
(1) rheum officinale is crushed, crosses 120 mesh sieves, take lower part of screen to be allocated as medicinal material to be extracted；
(2) under conditions of stir speed (S.S.) is 60r/min, use 5 times of quality of medicinal material to be extracted, weight/mass percentage composition for
80% ethanol water carries out extraction 60min for the first time at 25 DEG C to medicinal material to be extracted in the step (1)；Using vacuum
Pump carries out the first decompression to resulting material and filtered, and obtains extract solution I and dregs of a decoction I, wherein, the vacuum of vavuum pump is 0.7MPa,
Power of motor is 7.5kw, and suction filtration tank floor space is 7850cm2, handling capacity 0.65t/h；
(3) under conditions of stir speed (S.S.) is 60r/min, 3 times of dregs of a decoction I mass, weight/mass percentage composition are used as 70%
Ethanol water carries out second of extraction 60min at 60 DEG C to the step (2) Chinese medicine slag I；Using vavuum pump to gains
Material carries out the second decompression and filtered, and obtains extract solution II and dregs of a decoction II, wherein, the vacuum of vavuum pump is 0.65MPa, power of motor
For 7.5kw, suction filtration tank floor space is 7850cm2, handling capacity 0.65t/h；
(4) under conditions of stir speed (S.S.) is 60r/min, 2 times of dregs of a decoction II mass, weight/mass percentage composition are used as 60%
Ethanol water carries out third time extraction 30min at 60 DEG C to the step (3) Chinese medicine slag II；Using vavuum pump to gains
Material carries out the 3rd decompression and filtered, and obtains extract solution III and dregs of a decoction III, wherein, the vacuum of vavuum pump is 0.6MPa, motor work(
Rate is 7.5kw, and suction filtration tank floor space is 7850cm2, handling capacity 0.65t/h；
(5) extract solution III in extract solution II and step (4) is merged in the step (2) in extract solution I, step (3), in
Vacuum<Under conditions of 0.75MPa, temperature are 50 DEG C, stir speed (S.S.) is 60r/min, using vavuum pump to being closed in 3t reactors
And extract solution carry out vacuum-concentrcted, be concentrated into the 10% of the extract solution original volume, obtain Physcion.
The method comparative result of table 3
Extracting method provided by the invention is used it can be seen from above example and comparative example, can be to big in medicinal material
Flavine methyl ether is fully extracted, while can realize and other active materials in medicinal material are fully extracted；And the present invention carries
The method production efficiency of confession is high, running cost is low, suitable for industrialized production.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of method for extracting Physcion, comprises the following steps：
(1) medicinal material containing Physcion is extracted using ethanol water；
(2) material that the step (1) obtains is centrifuged, obtains extract solution and the dregs of a decoction；
(3) extract solution that the step (2) obtains is concentrated, obtains Physcion.
2. according to the method for claim 1, it is characterised in that be extracted in the step (1) stir speed (S.S.) for 50~
Carried out under conditions of 70r/min.
3. method according to claim 1 or 2, it is characterised in that the quality percentage of ethanol water in the step (1)
Content is 40%~90%.
4. according to the method for claim 3, it is characterised in that the number of extraction is 3~4 times in the step (1).
5. according to the method for claim 4, it is characterised in that the time extracted every time is independently selected from 20~70min.
6. according to the method for claim 1, it is characterised in that the centrifugation rate of centrifugation is in the step (2)
7000~8000r/min.
7. the method according to claim 1 or 6, it is characterised in that the time centrifuged in the step (2) for 3~
15min。
8. according to the method for claim 1, it is characterised in that concentration is that extract solution is concentrated into institute in the step (3)
State the 5%~15% of extract solution original volume.
9. the method according to claim 1 or 8, it is characterised in that the temperature of concentration is 45~55 in the step (3)
℃。
10. according to the method for claim 9, it is characterised in that in the step (3) vacuum of concentration for 0.65~
0.8MPa。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710598788.4A CN107353191A (en) | 2017-07-21 | 2017-07-21 | A kind of method for extracting Physcion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710598788.4A CN107353191A (en) | 2017-07-21 | 2017-07-21 | A kind of method for extracting Physcion |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698638A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | Method for extracting highly purified chrysophanic acid from roots and stems of rhubarb |
| CN102010316A (en) * | 2009-09-04 | 2011-04-13 | 中国药科大学 | Method for extracting high-purity frangula emodin from polygonum cuspidatum |
| CN104817445A (en) * | 2015-04-16 | 2015-08-05 | 聊城大学 | Method for separating purified physcion and emodin from giant knot weed |
| CN105061182A (en) * | 2015-09-08 | 2015-11-18 | 聊城大学 | Method for extracting, separating and purifying emodin and physcion from polygonum cuspidatum |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010316A (en) * | 2009-09-04 | 2011-04-13 | 中国药科大学 | Method for extracting high-purity frangula emodin from polygonum cuspidatum |
| CN101698638A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | Method for extracting highly purified chrysophanic acid from roots and stems of rhubarb |
| CN104817445A (en) * | 2015-04-16 | 2015-08-05 | 聊城大学 | Method for separating purified physcion and emodin from giant knot weed |
| CN105061182A (en) * | 2015-09-08 | 2015-11-18 | 聊城大学 | Method for extracting, separating and purifying emodin and physcion from polygonum cuspidatum |
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