CN107343826A - New Pancreatic duct metal support - Google Patents
New Pancreatic duct metal support Download PDFInfo
- Publication number
- CN107343826A CN107343826A CN201610292909.8A CN201610292909A CN107343826A CN 107343826 A CN107343826 A CN 107343826A CN 201610292909 A CN201610292909 A CN 201610292909A CN 107343826 A CN107343826 A CN 107343826A
- Authority
- CN
- China
- Prior art keywords
- pancreatic duct
- metal support
- duct metal
- support
- ductus pancreaticus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002184 metal Substances 0.000 title claims abstract description 117
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- 239000000463 material Substances 0.000 claims abstract description 32
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- 238000013268 sustained release Methods 0.000 claims description 8
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A61M1/0023—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/84—Drainage tubes; Aspiration tips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Surgery (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention relates to a kind of Pancreatic duct metal support for medically treating stricture of pancreatic duct, Pancreatic duct metal support includes latticed rack body, the medication coat coated in the polymeric material overlay film on the rack body and coated in the suppression epithelial growth on the rack body that elastic metallic material is formed, the Pancreatic duct metal support body includes bracket body part and diameter is more than the horn mouth holder part of bracket body part diameter, and the outer surface of the bracket body part of the Pancreatic duct metal support includes multiple bulge-structures.Using the Pancreatic duct metal support of this structure, epithelial tissue hyperplasia is not susceptible to, can well treat stricture of pancreatic duct in a long time；And be not susceptible to shift in use, it is not easy to block the path of branch's ductus pancreaticus.
Description
Technical field
The present invention relates to technical field of medical instruments, is a kind of new ductus pancreaticus for being used to treat stricture of pancreatic duct specifically
Metallic support.
Background technology
Stricture of pancreatic duct is the common lesion of pancreatic disease, and malignant stricture is common in cancer of pancreas, and benign stricture is common in chronic pancreas
Adenositis.Good pernicious stricture of pancreatic duct can cause pancreatemphraxis, cause pancreatic juice drainage not smooth, secondary ductus pancreaticus expansion or false cyst,
Cause or aggravate stomachache, indigestion symptom, or even induce pancreatitis acute attack repeatedly, to the serious shadow of Patients With Chronic Pancreatitis
Quality of life is rung, then are significantly shortened life cycle to Pancreas cancer patients.The traditional treatment of stricture of pancreatic duct is based on surgical operation, but phase
It is serious to close complication, and some patientss can not be resistant to operation；Therefore clinically stents of pancreatic duct is put under generally use scope in recent years
Enter art to treat stricture of pancreatic duct.
Pancreatic Duct Stenting mainly uses plastic stent under scope at present, and plastic stent can temporarily solve pancreatic juice circulation not
Smooth symptom, but its pipe is thin, and the effect expanded at stricture of pancreatic duct is weaker, and after pulling out, ductus pancreaticus quickly can ISR.The plastics pancreas
The general service life of pipe holder be 3 months, more than 3 months after most of plastic stent can occur obstruction, it is necessary to repeatedly take out and
Insert again, increase patient suffering and medical expense.And due in pancreas main pancreatic duct send many branch's ductus pancreaticus, it is columnar
Plastic stent while pancreatic juice in main pancreatic duct is drained is possible to that branch's ductus pancreaticus can be blocked, so as to cause branch's ductus pancreaticus expansion, pancreas
Glandular substance of prostate fibrosis.
After the narrow ductus pancreaticus of Metal stent placement can self expandable to original diameter, lasting expansion is produced to narrow tube wall
Power, bracket stable is kept, avoid placing the frequent replacing after plastic stent.Compared with plastic stent, opening is more preferable for it, is not easy
Block, duration length.But metallic support also has the shortcomings that obvious, metallic support easily causes ductus pancreaticus inner tissue hyperplasia, produces new
Narrow and obstruction, clinical test proved, overlay film type metallic support is placed in ductus pancreaticus, ductus pancreaticus still inevitably occurs
Epithelial cell or tumor cell proliferation infiltration cause adhesion or even to block support, and can not pull out support in the later stage；And metal
The typically cylindrical outward appearance of support, the metallic support of the especially outer overlay film of this kind of support, easily occur when in use into ductus pancreaticus
Side or lateral displacement, it is impossible to reach expected action effect, largely ductus pancreaticus medial displacement, support are moved fully into if occurring
In ductus pancreaticus, then it is only capable of taking out support by surgical operation, increases the pain and medical expense of patient.
In summary, there is provided it is a kind of can be used for treatment stricture of pancreatic duct, be not susceptible to epithelium or tumour cell adhesion and can
In drainage branch ductus pancreaticus pancreatic juice, usage time is longer and is not susceptible to the Pancreatic duct metal support of displacement and turns into this medical field
Need badly.
The content of the invention
The technical problem urgently to be resolved hurrily based on more than, the invention provides a kind of Pancreatic duct metal support, including elastic metallic
Latticed rack body that material is formed, coated in the polymeric material overlay film on rack body, and coated on rack body
Suppression ductus pancreaticus or tumor epithelia (hereinafter referred to as " epithelium ") growth medication coat.The overlay film of metallic stent body can prevent
Grid of the epithelial cell along metallic stent body grows and enters support pipeline and induce blocking.Suppress the medication coat of epithelial growth
Pancreatic duct metal support can effectively be suppressed hyperplasia and adhesion occurs with the epithelial cell being in contact, reduced support and blocked up by proliferative cell
The possibility of plug, and contribute to support pulls out operation.
Ductus pancreaticus metal provided by the present invention, when polymeric material overlay film is located at whole inner surfaces of Pancreatic duct metal support
When, medication coat is located at whole outer surfaces of the metallic stent body of Pancreatic duct metal support；When polymeric material overlay film is located at pancreas
During whole outer surfaces of pipe metallic support, medication coat is located at the interior of two end regions of the metallic stent body of Pancreatic duct metal support
Surface.When the inner surface overlay film of Pancreatic duct metal support, histocyte adhesion easily occurs on exposed metallic support, therefore apply
All positions that the medicine of the suppression epithelial growth of support whole outer surface releasably contacts to support with ductus pancreaticus inwall are overlying on, from
And further prevent to produce epithelial hyperplasia in ductus pancreaticus；When the outer surface overlay film of Pancreatic duct metal support, body cavity inner tissue is thin
Normally only there is the two-port neighbouring position of support in born of the same parents' hyperplasia, it is therefore desirable in the end regions of rack body two of Pancreatic duct metal support
Inner surface on coating suppress epithelial growth medication coat.Medication coat ensure that the unimpeded of Pancreatic duct metal support pipeline, prolong
The service life of long Pancreatic duct metal support, reduce sufferer pain and medical treatment cost.
Pancreatic duct metal support provided by the present invention, medication coat in flexible medicament sustained-release matrix by being dissolved with
The medicine for suppressing epithelial growth is formed.Compared to metallic support directly with the medicine dipping for suppressing epithelial growth, set up medicine and delay
The duration for the medicine for suppressing epithelial growth can be extended as far as possible by releasing matrix, ensure the good sustained release effect of medicine.Medicament slow release
Matrix will have appropriate medicament slow release curve, and have certain elasticity, and Thermosensitive Material Used for Controlled Releasing of Medicine can include phosphocholine, chitosan
Derivative or inorganic matter.Suppress epithelial growth medicine include taxol, cyclosporin, rapamycin, rheum emodin, fill in rice
The combination of one or more of medicines in pine, mitomycin, D actinomycin D, bleomycin, adriamycin, so as to effectively suppress into fibre
Mitosis and the propagation of cell are tieed up, the precipitation of collagen and fibronectin is prevented, reduces granulation tissue hyperplasia, prevent tissue
Adhesion, be advantageous to the extraction after support long-time indwelling.
To solve the problems, such as stents of pancreatic duct displacement, the rack body of Pancreatic duct metal support provided by the present invention includes support
Main part and diameter are more than the horn mouth holder part of rack body diameter；Pancreatic duct metal support is being put into operating position
Afterwards, bracket main body portion is placed in ductus pancreaticus, and horn mouth holder part is placed in the duodenum outside ductus pancreaticus mouth.Using said structure
Pancreatic duct metal support, it is good to the dilatancy of ductus pancreaticus wall, can effectively treat ductus pancreaticus caused by chronic pancreatitis or cancer of pancreas it is good/
Malignant stricture, and ductus pancreaticus mouth Outboard Sections are adopted as the bell-mouth structure of air of diameter increase, can prevent stents of pancreatic duct well
Occur in validity period to the displacement on the inside of ductus pancreaticus.
The exterior surface area of the bracket body part of Pancreatic duct metal support provided by the present invention includes multiple bulge-structures.
On the one hand the bulge-structure can increase the contact friction force of rack surface and ductus pancreaticus, effectively prevent stents of pancreatic duct to ductus pancreaticus inner side
And/or the displacement in outside；Another aspect bulge-structure makes to produce gap between ductus pancreaticus wall and rack body, can drain branch's pancreas
Pancreatic juice in pipe, avoid the blocking of branch's ductus pancreaticus.
Preferably, the bulge-structure being integrally formed when the bulge-structure of anti-displacement is makes rack body with rack body,
That is, knit out when making metallic stent body or laser ablation goes out the rack body with bulge-structure.Bulge-structure one
Determine to increase the external diameter of support in degree, extend narrow ductus pancreaticus, not only increase the friction between rack surface and ductus pancreaticus wall
Power, prevent displacement of the stents of pancreatic duct during indwelling；And serve the effect of drainage branch ductus pancreaticus.
Preferably, when overlay film is located at metallic stent body outer surface, the bulge-structure of anti-displacement is in rack outer surface
Covering material on formed, the horn mouth towards support from covering material surface roll the microtrabeculae of polymeric material that tiltedly extends
Ridge；When overlay film is located at metallic stent body inner surface, the bulge-structure of anti-displacement is the metallic stent body in support
Upper formation, from the crosspoint of the grid on metallic stent body surface towards the horn mouth of support roll the polymeric material that tiltedly extends
The microtrabeculae ridge of material.It is further preferred that microtrabeculae ridge can be cylinder or polyhedron prism, and its top surface is configured to
With the diameter parallel of bracket body part.Microtrabeculae ridge is relative to form the support of " giving birth to " sample with ductus pancreaticus tube wall, not only extends
Ductus pancreaticus tube wall, the frictional force between support and ductus pancreaticus tube wall is increased, and inclined what Pancreatic duct metal support generation shifted laterally
Xiang Shi, the microtrabeculae ridge of " giving birth to " structure is in close contact with ductus pancreaticus wall occurs " locking " effect, considerably increases deboost
To prevent support to ductus pancreaticus lateral displacement, be more effectively prevented from stents of pancreatic duct in use towards the shifting on the outside of ductus pancreaticus
Position.Likewise, microtrabeculae ridge makes to form gap between the rack body of Pancreatic duct metal support and ductus pancreaticus wall, effectively play and drawn
The effect of flow branching ductus pancreaticus.
Recovery is surrounded with the periphery grid of the apex zone of the horn section of Pancreatic duct metal support provided by the invention
Line；One end of exhausting line is the fixing end being connected with the apex zone of horn mouth holder part, and the other end is indwelling in horn mouth
Free end outside holder part.The opening of horn mouth holder part can be punctured into the point-like of diameter very little after free end is tensed
Structure, pull on exhausting line easily can extract Pancreatic duct metal support out of ductus pancreaticus, and the tubular bracket knot for the closure that is open
Structure is transported and removed more easily in body cavity.
Pancreatic duct metal support provided by the present invention, bracket body part can be linearly extended columnar structured.Cylinder
Shape rack body is traditional stent configuration, and its is simple for production, and cost is relatively low, and good to the supportive of ductus pancreaticus wall.
As the further preferred structure of the present invention, the bracket body part of Pancreatic duct metal support can be that multiple cydariform sections are first
The linear structure that tail is mutually connected into.The cylinder-shaped bracket consistent compared to external diameter, big path is interlaced with each other to be smoothly connected
Cydariform section it is end to end into the support of linear structure be less susceptible to slide in narrow ductus pancreaticus, prevent stents of pancreatic duct from making
The displacement of used time.
As the further preferred structure of the present invention, the bracket body part of Pancreatic duct metal support can be that spatially spiral prolongs
That stretches is columnar structured.The Pancreatic duct metal support in an unstressed state, can keep helical configuration spatially naturally；The pancreas
Pipe metallic support is compressed into straight configuration to be delivered near ductus pancreaticus in scope transmission system by narrow cavity, and due to pancreas
The constraint of tube wall, the support are released into ductus pancreaticus with straight configuration；Be released into linear support revert back to without should
The inner principles of helical configuration under power state, therefore expansion increase of the support to ductus pancreaticus wall, are increased between the two significantly
Stiction so that stents of pancreatic duct is less susceptible to be shifted over when in use.
Brief description of the drawings
The present invention is described in more detail with reference to the accompanying drawings and detailed description：
The structure sectional view for the Pancreatic duct metal support that Fig. 1 is provided by embodiments of the invention 1；
The structure sectional view for the Pancreatic duct metal support that Fig. 2 embodiments of the invention 2 are provided；
The structure sectional view for the Pancreatic duct metal support that Fig. 3 embodiments of the invention 3 are provided；
The structure sectional view for the Pancreatic duct metal support that Fig. 4 embodiments of the invention 4 are provided；
The rack body front view for the Pancreatic duct metal support that Fig. 5 is provided by embodiments of the invention 5；
The rack body stereogram for the Pancreatic duct metal support that Fig. 6 is provided by embodiments of the invention 6.
Component label instructions：
1st, 1 ', 1 〞 bracket body parts
2 horn mouth holder parts
3 overlay films
The bulge-structure that 4 metallic stent bodies are formed
The microtrabeculae ridge of 4 ' polymeric materials
5 exhausting lines
6 suppress the medication coat of epithelial growth
Embodiment
Presently in connection with accompanying drawing, better embodiment of the invention is discussed in detail.Although description of the invention will combine each
Embodiment is introduced together, but this feature for not representing this invention is only limitted to the several embodiments.On the contrary, combine real
It is to be possible to the other selections extended to cover the claim based on the present invention that the mode of applying, which makees the purpose that invention is introduced,
Or transformation.In order to which the depth provided to the present invention understands, many concrete details will be included in describing below.The present invention can also
Implement without using these details.In addition, in order to avoid the emphasis of the chaotic or fuzzy present invention, some details will in the de-scription
It is omitted.
In addition, used "left", "right", " top ", " bottom " are to preferably describe the present invention in the following description
Better embodiment and set, should not be construed as limiting the invention.
1. embodiment 1
Fig. 1 is the structure sectional view for the Pancreatic duct metal support that embodiments of the invention 1 are provided, wherein, overlay film is located at pancreas
The outer surface of pipe metallic stent body.Pancreatic duct metal support includes rack body made of elastic metallic material and coated on support
The overlay film of body outer surface.The material of metallic stent body can be in the range of room temperature to human body temperature, have super-elasticity power
Learn the marmem of performance, such as Ti-Ni alloy；Metallic stent body metal wire knitted can form made of above-mentioned material,
Or carved and formed from bulk metal material using laser etching process.The material of overlay film is typically designed as polymeric material,
Including polyurethane, silicones etc., can effectively prevent hyperplastic tissue in ductus pancreaticus by the mesh on metallic stent body grow into
Rack bore and block support path.
In embodiments of the invention 1, the right part of Pancreatic duct metal support is in ductus pancreaticus, traditional to be placed in when using
Cylinder-shaped bracket main part 1, relative to cylinder-shaped bracket main part 1, the left part of Pancreatic duct metal support is when using
ID, the diameter being placed in outside ductus pancreaticus mouth are significantly increased to prevent horn mouth cradle portion of the support to ductus pancreaticus medial displacement
Divide 2；The outer surface of whole metallic stent body all have overlay film 3；The periphery net of the apex zone of broadening formation holder part 2
Exhausting line is surrounded with lattice；One end of exhausting line 5 is the fixing end that is connected with the apex zone of horn mouth holder part, the other end
It is indwelling in the free end outside horn mouth holder part；, only need to be under scope when treatment end need to pull out Pancreatic duct metal support
The free end of exhausting line 5 is pulled, the broadening formation holder part 2 of Pancreatic duct metal support just bounces back a bit, to pull on recovery
Support can be pulled out and reclaimed by line 5.
As shown in figure 1, the point-like that the medication coat 6 for suppressing epithelial growth is arranged at the left and right ends of Pancreatic duct metal support is cloudy
Shadow zone domain, medication coat 6 are located at the inner surface of metallic stent body.Because the Pancreatic duct metal support in embodiment 1 is outer overlay film
Support, cytoadherence will not be typically produced on the overlay film of high molecular polymer, therefore only need to be in two end regions of stent inner surface
The medication coat 6 that coating suppresses epithelial growth is that can reach the purpose for preventing hyperplasia from blocking support.The medication coat by
The medicine of dissolution inhibition epithelial growth is formed in flexible medicament sustained-release matrix.Compared to metallic support directly with suppression
The medicine dipping of skin growth, the release time for suppressing epithelial growth medicine can be extended as far as possible by setting up medicament sustained-release matrix, ensure medicine
The good sustained release effect of thing.Medicament controlled-release coating will have appropriate medicament slow release curve, and have certain elasticity, can include phosphorus
Sour choline coating, chitosan derivatives coating, inorganic coating.Suppressing the medicine of epithelial growth includes taxol, cyclosporin, thunder
One or more of medicines in pa mycin, rheum emodin, dexamethasone, mitomycin, D actinomycin D, bleomycin, adriamycin
Combination, so as to effectively suppress fibroblastic mitosis and propagation, the precipitation of collagen and fibronectin is prevented, is reduced
Granulation tissue hyperplasia, tissue adhesion is prevented, extracted after being easy to support long-time indwelling.Therefore, can be thin by modulating suppression epithelium
The medicament slow release cycle of born of the same parents' hyperplasia controls the service life of Pancreatic duct metal support, typically can extend to 6 months.
Embodiment 1 as shown in Figure 1, it is woven with or is carved with and prop up on the cylinder-shaped bracket body 1 of Pancreatic duct metal support
The integrally formed metal bump structure 4 of frame body, accordingly, this is attached to on raised cylinder-shaped bracket body outer surface
Overlay film 3 can also produce projection therewith.Therefore, it is real compared to the outer overlay film Pancreatic duct metal support without bulge-structure, the present invention
Apply the support that example 1 is provided and increase expansion to narrow ductus pancreaticus wall, and increase the frictional resistance for preventing stent migration.Separately
Outside, main pancreatic duct separates many branch's ductus pancreaticus to supply pancreatic juice in pancreas, due to traditional cylindrical plastic stents of pancreatic duct outer surface
With the close contact at stricture of pancreatic duct, the paths of many branch's ductus pancreaticus is plugged；In the present invention, the setting of bulge-structure 4, makes
Gap is generated between Pancreatic duct metal support and ductus pancreaticus wall, so as to open path for the unobstructed outflow of pancreatic juice in branch's ductus pancreaticus.
2. embodiment 2
Fig. 2 is the sectional view for the Pancreatic duct metal support that embodiments of the invention 2 are provided, and wherein overlay film is located at ductus pancreaticus metal
The outer surface of rack body.It is similar to Example 1, the Pancreatic duct metal support include rack body made of elastic metallic material and
Overlay film coated on rack body outer surface；The right part of Pancreatic duct metal support is traditional cylinder-shaped bracket main part 1,
Relative to cylinder-shaped bracket main part 1, the left part of Pancreatic duct metal support is the horn mouth cradle portion that diameter significantly increases
Divide 2, can effectively prevent support medial displacement and slip into ductus pancreaticus；The outer surface of whole metallic stent body all have overlay film 3；
The top of broadening formation holder part 2 is provided with exhausting line 5, facilitates pulling out and reclaiming for support；Near Fig. 2 medium-height trestles both ends
Dot-hatched region shown in, the medication coat 6 for suppressing epithelial growth is arranged at the left and right ends region of Pancreatic duct metal support
Inner surface；Same as Example 1, the setting of the overlay film 3 and medication coat 6 of rack outer surface can substantially reduce Pancreatic duct metal support
The probability blocked by epithelial proliferation cell is so as to extend the service life of Pancreatic duct metal support, and therefore not to repeat here.
According to embodiment 2, it is provided with from overlay film surface and tilts on the overlay film of the cylinder-shaped bracket main body of Pancreatic duct metal support
The microtrabeculae ridge 4 ' of the polymeric material upwardly extended.The position of microtrabeculae ridge 4 ' is unlimited, can both be located at metallic support sheet
Network central area (such as the position of the microtrabeculae ridge 4 ' that dotted circle is illustrated in Fig. 2) on body, may be alternatively located at gold
Belong on the crosspoint of the network of rack body (position as tilted the microtrabeculae ridge 4 ' anticipated shown in column in Fig. 2)；It is micro-
Post ridge 4 ' can use same polymeric material, such as polyurethane, silicones with overlay film, can both pour and be integrally formed with overlay film
(as shown in Figure 2), it can be independently formed again independently of overlay film.Preferably, the shape of microtrabeculae ridge 4 ' can be cylinder or multiaspect
Body prism, and for the relative position of center rest and ductus pancreaticus wall, the top of microtrabeculae is arranged to the axle with cylinder-shaped bracket main body
The parallel top surface of line.Compared to the cylinder-shaped bracket main body without bulge-structure, the microtrabeculae ridge 4 ' has more been expanded narrow
Ductus pancreaticus, the critical stiction for being shifted over Pancreatic duct metal support is increased, and " giving birth to " structure is in close contact with ductus pancreaticus wall
And " locking " effect is produced, considerably increase the resistance that Pancreatic duct metal support shifts laterally.Other, microtrabeculae ridge 4 makes
Gap is generated between Pancreatic duct metal support and ductus pancreaticus wall, the outflow for pancreatic juice in branch's ductus pancreaticus opens path, thus plays
The effect of drainage branch ductus pancreaticus.
3. embodiment 3
Fig. 3 is the profile of the Pancreatic duct metal support of the offer of embodiment 3 of institute of the invention, and wherein overlay film is located at ductus pancreaticus metal
The inner surface of rack body.The right part of Pancreatic duct metal support is traditional cylinder-shaped bracket main part 1, and left part is
The horn mouth holder part 2 that diameter significantly increases, fallen into preventing support medial displacement in ductus pancreaticus；Whole metallic stent body
Inner surface all have overlay film 3；The top of broadening formation branch part 2 is provided with exhausting line 5, facilitates pulling out and returning for support
Receive；As shown in figure 3, the medication coat 6 for suppressing epithelial cell growth is coated on whole outer surfaces of Pancreatic duct metal support body, can
In the contact area that medicament slow release is entered to ductus pancreaticus and support in longer time, so as to ensure Pancreatic duct metal support in medicine
It is sustained in the cycle and does not produce adhesion with ductus pancreaticus parietal cell.
According to embodiment 3, the projection of the cylinder-shaped bracket body portion outer surface of Pancreatic duct metal support is metal material shape
Into bulge-structure 4, braiding style when bulge-structure 4 can be braided metal rack body is raised, or laser ablation gold
Belong to the raised style carved out during rack body.Compared to the interior precoated metal support on smooth cylindrical surface, bulge-structure 4 both increased
Big frictional force of the Pancreatic duct metal support with ductus pancreaticus inwall, so as to effectively prevent the displacement that may occur during use；Again
The effect of outflow pancreatic juice in drainage branch ductus pancreaticus is served, causes branch's ductus pancreaticus expansion, pancreas so as to prevent branch's ductus pancreaticus from blocking
Glandular substance of prostate fibrosis.
4. embodiment 4
Fig. 4 is the profile for the Pancreatic duct metal support that embodiments of the invention 4 are provided, and wherein overlay film is located at ductus pancreaticus metal
The inner surface of rack body.The right part of the Pancreatic duct metal support is traditional cylinder-shaped bracket main part 1, left part
The horn mouth holder part 2 significantly increased for diameter, to prevent support to ductus pancreaticus medial displacement；Entirely metallic stent body is interior
Surface all have overlay film 3；The top of horn mouth holder part 2 is provided with exhausting line 5, facilitates pulling out and reclaiming for support；Such as
Shown in Fig. 4, suppress epithelial cell growth medication coat 6 be coated on Pancreatic duct metal support body whole outer surfaces, can compared with
Medicament slow release is entered in the contact area of ductus pancreaticus and support in the long time, so as to ensure sustained release of the Pancreatic duct metal support in medicine
Adhesion is not produced in cycle with epithelial cell.According to embodiment 4, as tilted column and dashed circle institute ductus pancreaticus metal branch in Fig. 4
The bulge-structure set in the cylinder-shaped bracket main part of frame be formed on the metallic stent body of support, from metal branch
The microtrabeculae protrusion of the polymeric material of the horn mouth holder part extension of the crosspoint inclined support of grid on frame body surface
Thing 4 '.The microtrabeculae ridge 4 ' can use same polymeric material, such as polyurethane, silicones with overlay film, it is preferable that microtrabeculae is convex
The shape for going out thing 4 ' can be cylinder or polyhedron prism, and for the relative position of center rest and ductus pancreaticus wall, the top of microtrabeculae
Face sets the diameter parallel with cylinder-shaped bracket main body.Should " giving birth to " structure microtrabeculae ridge 4 ' and ductus pancreaticus wall be in close contact and
" locking " effect is produced, considerably increases the resistance that Pancreatic duct metal support shifts laterally；Likewise, the microtrabeculae ridge 4 ' rises
The effect of the pancreatic juice of outflow in drainage branch ductus pancreaticus is arrived.
5. embodiment 5
The front view of the rack body for the Pancreatic duct metal support that Fig. 5 is provided by embodiments of the invention 5.In order to increase branch
Expansion and increase of the frame body part to narrow ductus pancreaticus make the critical friction power that rack body is shifted in ductus pancreaticus, such as Fig. 5
It is shown, the bracket body part of Pancreatic duct metal support body can be arranged to cydariform section it is end to end into the ˊ of linear structure 1.
Similar to embodiment 1-4, the overlay film of the Pancreatic duct metal support described by embodiment 5 may be disposed at whole outer surfaces of rack body
Or whole inner surfaces, accordingly, the medication coat for suppressing epithelial cell growth may be disposed at the both ends areas adjacent of rack body
Or whole outer surfaces of rack body；And set on the ˊ of cydariform section bracket body part 1 rise prevent stent migration and drainage branch
The bulge-structure of ductus pancreaticus effect can be the bulge-structure 4 for the metal material being integrally formed with metallic stent body, or be correspondingly
The microtrabeculae ridge 4 ' of the polymeric material of " giving birth to " for being formed on overlay film or on the crosspoint of metallic stent body surface mesh.
Though the various concrete structures of above-mentioned support are shown not in the drawings, those skilled in the art can be from the description of embodiment 1 to 4
In exactly, unambiguously determine any of the above structure, therefore will not be described here.
6. embodiment 6
The schematic perspective view of the rack body for the Pancreatic duct metal support that Fig. 6 is provided by embodiments of the invention 6.In order to increase
Big expansion and increase of the bracket body part to narrow ductus pancreaticus makes the critical friction power that rack body is shifted in ductus pancreaticus, such as
Shown in Fig. 6, traditional linearly extended cylindrical-shaped main body part of Pancreatic duct metal support body can be replaced by spatially spiral shell
The 〞 of cylinder-like structure 1 of extension is revolved, and under stressless nature, the rack body of the Pancreatic duct metal support can keep empty
Between spiral form.In use, the support is compressed to straight configuration to be sent near ductus pancreaticus mouth in scope transmission system,
And under the constraint effect of narrow ductus pancreaticus wall, discharged with the configuration of near linear to ductus pancreaticus；Support after release has extensive
Multiple spiral elastic-restoring force, increases the pressure and stiction to ductus pancreaticus wall.Similar to embodiment 1-4, embodiment 6 is retouched
The overlay film for the Pancreatic duct metal support stated may be disposed at whole outer surfaces of rack body or whole inner surfaces, accordingly, in suppression
The medication coat of epidermal growth may be disposed at the both ends areas adjacent of rack body or whole outer surfaces of rack body；And prop up
Serving of being set on frame body part prevent stent migration and drain branch's ductus pancreaticus bulge-structure can for and metallic support sheet
The bulge-structure 4 of the integrally formed metal material of body, or correspondingly on overlay film or metallic stent body surface mesh intersection
The microtrabeculae ridge 4 ' of the polymeric material of " giving birth to " for being formed on point.Though the various concrete structures of above-mentioned support are not in the drawings
It has been shown that, but those skilled in the art can exactly, unambiguously determine any of the above knot from the description of embodiment 1 to 4
Structure, therefore will not be described here.
The better embodiment of the present invention is illustrated above, but the invention is not restricted to this, without departing from the spirit
In the range of, various modifications can be carried out to implement.
Shape such as the horn section of Pancreatic duct metal support body provided by the invention is not limited to accompanying drawing in this specification
Shown structure, as long as diameter significantly increases relative to bracket body part, can play and prevent support to ductus pancreaticus medial movement
, rise position-limiting action structure it is within the scope of the present invention.
And for example the horn section outer surface of Pancreatic duct metal support may also set up above-mentioned various bulge-structure types, such as gold
Belong to the microtrabeculae ridge of material bulge-structure or the polymeric material of " giving birth to ".
And for example the microtrabeculae ridge of the polymeric material of Pancreatic duct metal support outer surface can be unified shape, or not
The combination of same shape (cylinder and polyhedron prism).
And for example Pancreatic duct metal support appearance metallic stent body formed bulge-structure can be annular, intersect annular with
Form latticed, or other shapes that can arbitrarily form bulge-structure.
Claims (14)
- A kind of 1. new Pancreatic duct metal support, it is characterised in that：The Pancreatic duct metal support includes the latticed rack body of elastic metallic material composition, coated on the rack body Polymeric material overlay film and coated on the rack body suppression epithelial growth medication coat.
- 2. new Pancreatic duct metal support as claimed in claim 1, it is characterised in that:When the polymeric material overlay film is located at whole inner surfaces of the Pancreatic duct metal support body, the medication coat position In whole outer surfaces of the rack body of the Pancreatic duct metal support；When the polymeric material overlay film is located at whole outer surfaces of the Pancreatic duct metal support body, the medication coat position In the inner surface of two end regions of the rack body of the Pancreatic duct metal support.
- 3. new Pancreatic duct metal support as claimed in claim 2, it is characterised in that the medication coat is by flexible Formed in medicament sustained-release matrix dissolved with the medicine for suppressing epithelial growth.
- 4. new Pancreatic duct metal support as claimed in claim 3, it is characterised in that the sustained-release matrix include phosphocholine, Chitosan derivatives or inorganic matter.
- 5. new Pancreatic duct metal support as claimed in claim 3, it is characterised in that the medicine for suppressing epithelial growth includes In taxol, cyclosporin, rapamycin, rheum emodin, dexamethasone, mitomycin, D actinomycin D, bleomycin, adriamycin One or more of medicines combination.
- 6. new Pancreatic duct metal support as claimed in claim 1, it is characterised in that the Pancreatic duct metal support body includes branch Frame body part and diameter are more than the horn mouth holder part of the bracket body part diameter；After the Pancreatic duct metal support is put into operating position, the bracket main body portion is placed in ductus pancreaticus, the loudspeaker Mouth holder part is placed in the duodenum outside ductus pancreaticus mouth.
- 7. the new Pancreatic duct metal support as described in claim 1 or 6, it is characterised in that the support of the Pancreatic duct metal support The exterior surface area of main part includes multiple bulge-structures.
- 8. new Pancreatic duct metal support as claimed in claim 7, it is characterised in that the bulge-structure is making rack body When with rack body be integrally formed bulge-structure.
- 9. new Pancreatic duct metal support as claimed in claim 7, it is characterised in thatWhen the overlay film is located at the Pancreatic duct metal support body outer surface, the bulge-structure is in the rack outer surface Covering material on formed, from covering material surface towards the horn mouth holder part of the support roll the polymer that tiltedly extends The microtrabeculae ridge of material；When the overlay film is located at metallic stent body inner surface, the bulge-structure is the metallic stent body in the support Horn mouth holder part on upper formation, grid from metallic stent body surface crosspoint towards the support is rolled and tiltedly prolonged The microtrabeculae ridge for the polymeric material stretched.
- 10. new Pancreatic duct metal support as claimed in claim 9, it is characterised in that the microtrabeculae ridge can be cylinder Or polyhedron prism, and the top surface of the microtrabeculae ridge is configured to the diameter parallel with the bracket body part.
- 11. the new Pancreatic duct metal support as described in claim 6 or 8 or 9, it is characterised in that the horn mouth holder part Apex zone periphery grid in be surrounded with exhausting line；One end of the exhausting line is the top with the horn mouth holder part The fixing end of end regions connection, the other end are indwelling in the free end outside horn mouth holder part.
- 12. new Pancreatic duct metal support as claimed in claim 6, it is characterised in that the bracket main body portion is divided into straight line and prolonged That stretches is columnar structured.
- 13. new Pancreatic duct metal support as claimed in claim 6, it is characterised in that the bracket main body portion is divided into multiple drums The structure of the end to end shape that is in line of shape section.
- 14. new Pancreatic duct metal support as claimed in claim 6, it is characterised in that the bracket main body portion is divided into spatially What is extended spirally is columnar structured.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610292909.8A CN107343826A (en) | 2016-05-05 | 2016-05-05 | New Pancreatic duct metal support |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610292909.8A CN107343826A (en) | 2016-05-05 | 2016-05-05 | New Pancreatic duct metal support |
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| CN107343826A true CN107343826A (en) | 2017-11-14 |
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| CN201610292909.8A Pending CN107343826A (en) | 2016-05-05 | 2016-05-05 | New Pancreatic duct metal support |
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