CN107334780A - A kind of application of fucoidin in Orthodontic movement is controlled - Google Patents
A kind of application of fucoidin in Orthodontic movement is controlled Download PDFInfo
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- CN107334780A CN107334780A CN201710505828.6A CN201710505828A CN107334780A CN 107334780 A CN107334780 A CN 107334780A CN 201710505828 A CN201710505828 A CN 201710505828A CN 107334780 A CN107334780 A CN 107334780A
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- fucoidin
- correction model
- anchorage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
The invention discloses application of the fucoidin in orthodontic treatment.Fucoidin proposed by the invention can suppress osteoclast formation, increase Gegenbaur's cell is formed, and strengthen orthodontic anchorage；The postoperative cooperation of correction can reduce the retention time, increase skeletonization, tooth position is faster stablized, and reduce recurrence.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of application of fucoidin in Orthodontic movement is controlled.
Background technology
At present, the holding of the compliance, anchorage of patient and lack anchorage unit these problems and often annoying orthodontist,
And this is primarily due to lack effective anchorage device.Head cap face-bow, this is used to control anchorage while needs patient compliance
Application of the device in orthodontic treatment had at least century-old history.Although having applied for a long time, it is produced
Raw effect can only be described with general.Recent years, with the introducing of temporary anchorage device, whole patient compliance, anchorage
The prospect that protection, complicated wrong deformity simplify treatment is changed there occurs certain.However, that just as being occurred along with each change
Sample, due to lacking the perspective study result based on the evidence of its related stability, clinical practice and long-term prognosis, face
When anchorage device learning curve also accordingly deepened.Due to this technology is also very young and also treatment results be it is short-term,
And belonging to invasive injury for patients, its application is also subject to certain restrictions.
Meanwhile long-term stabilization is one important goal of correction.There are some researches show the bone of same septum interalveolare alveolar bone
After density has significant, correction to need wearing retainer tooth is stabilized in correction after terminating compared to difference afterwards before the treatment
On position, typically at least need to wear with retainer 1~2 year, the patient of some wrong jaw types even needs to wear use all the life, to patient with
Larger inconvenience is carried out, has had an impact to attractive in appearance and function.
And fucosan (Fucoidan), also referred to as fucoidin sulfuric ester, fucoidan, algal polysaccharide sulfuric acid
Ester, it is a kind of unique water-soluble polysaccharide for being combined with sulfate group, is fucoidin and gained after sulfate esterification, mainly deposits
In brown alga and some oceanic invertebrates.A large amount of scientific researches prove that fucoidin has bidirectional modulation immunity, clearly
Except free radical, anti-aging, anticoagulation and antithrombotic, antitumor and inhibition of HIV, gastronintestinal system disorder is eliminated, antiallergy, strengthens liver
Function, reduce high fat of blood and hypertension, stabilizing blood sugar is horizontal, and with promote skin regeneration, skin moisture-keeping etc. more than 20 with
On physiological function.
The content of the invention
In order to solve the above problems, it is thin that fucoidin proposed by the invention can suppress osteoclast formation, increase skeletonization
Born of the same parents are formed, and strengthen orthodontic anchorage；The postoperative cooperation of correction can reduce the retention time, increase skeletonization, tooth position is faster stablized, subtract
Few recurrence.
Application of the fucoidin proposed by the present invention in the medicine for preparing enhancing orthodontic anchorage.
Application of the fucoidin proposed by the present invention in the medicine in stage is kept after preparing for correction.
The present invention can suppress osteoclast formation, increase Gegenbaur's cell is formed, and be advantageous to strengthen local bone anchorage, reduce tooth
Tooth moves, and without invasive injury, patient is also relatively easy to receive；The present invention is taken in the postoperative cooperation of correction can reduce the retention time, increase
Addition bone, makes tooth position faster stablize, and reduces recurrence.
The present invention clinically can locally be positioned in the level in gingival sulcus fluid of Anchorage molar or be attached at the gum table of local Anchorage molar
Face, active drug composition contained therein will penetrate into periodontium, slow down tooth movement, enhancing anchorage so as to play it
Effect.
Wide material sources of the present invention are easy to get, and it is comparatively easy to prepare, and its polysaccharide component included has many benefits to body
Place, such as can antiallergy, antitumor, anti-obesity, anti-diabetic, anticoagulation is antiviral, immunomodulator, Cardioprotective, anti-liver
Disease, the effect such as anti-neuropathy and anti-adrenal gland activity, toxic side effect is small, can be long-term use of.
Brief description of the drawings
Fig. 1 is that correction model schematic is established in rat oral cavity.
Fig. 2 is the photo that rat establishes correction model.
Fig. 3 is the photo that rat establishes correction model.
Fig. 4 is that experimental group rat establishes correction model scans Micro-CT photo after 1 week.
Fig. 5 is that control rats establish correction model scans Micro-CT photo after 1 week.
Fig. 6 for establish correction model after 1 week rats during tooth movement apart from scatter diagram.
Fig. 7 is that experimental group rat establishes correction model scans Micro-CT photo after 2 weeks.
Fig. 8 is that control rats establish correction model scans Micro-CT photo after 2 weeks.
Fig. 9 for establish correction model after 2 weeks rats during tooth movement apart from scatter diagram.
Figure 10 is that experimental group rat establishes correction model scans Micro-CT photo after 3 weeks.
Figure 11 is that control rats establish correction model scans Micro-CT photo after 3 weeks.
Figure 12 for establish correction model after 3 weeks rats during tooth movement apart from scatter diagram.
Figure 13 for establish correction model after 1-3 weeks rats during tooth movement apart from line chart.
Embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment
From the Male Wistar Rats that 6 body weight are 220 ± 10g, it is randomly assigned to obtain experimental group and control group.
Fucoidin (50mg/kg, 5mg/ml) is injected intraperitoneally in experimental group daily, and control group intraperitoneal injection daily is isometric raw
Manage salt solution；Daily same time point duplicate injection, to maintain blood concentration.
Experimental group and control group establish correction model after 1w, are done with resin in maxillary central incisors and are even preced with, as anchorage；The upper jaw
Left side first molar is mobile tooth, is reinforced with nickel titanium coil spring, dynamometer dynamometry value is 50g.As shown in Figure 1, Figure 2 and Figure 3, Fig. 1
Correction model schematic is established for murine oral, Fig. 2 and Fig. 3 are the photo that mouse establishes correction model.
In preoperative, postoperative 1w, postoperative 2w, postoperative 3w scanning Micro-CT (micro computed tomography), and
The change of tooth displacement is measured, and carries out statistical analysis, as shown in Fig. 4-Figure 13, wherein Fig. 4, Fig. 7 and Figure 10 are followed successively by reality
Test group rat and establish correction model scans Micro-CT photo after 1 week, 2 weeks, 3 weeks；Fig. 5, Fig. 8 and Figure 11 are followed successively by control group
Rat establishes correction model scans Micro-CT photo after 1 week, 2 weeks, 3 weeks；Fig. 6, Fig. 9 and Figure 12, which are followed successively by, establishes correction mould
Type after 1 week, 2 weeks, 3 weeks rats during tooth movement apart from scatter diagram；Figure 13 for establish correction model after 1-3 weeks rats during tooth movement away from
Disintegrate line chart.
As a result show：Correction model is established after 1-3 weeks, control group tooth displacement is more than experimental group, and difference has system
Meter learns meaning (P ＜ 0.05).
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (2)
- A kind of 1. application of fucoidin in the medicine for preparing enhancing orthodontic anchorage.
- A kind of 2. application of fucoidin in the medicine in stage is kept after preparing for correction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710505828.6A CN107334780B (en) | 2017-06-28 | 2017-06-28 | Application of fucoidin in controlling orthodontic tooth movement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710505828.6A CN107334780B (en) | 2017-06-28 | 2017-06-28 | Application of fucoidin in controlling orthodontic tooth movement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107334780A true CN107334780A (en) | 2017-11-10 |
| CN107334780B CN107334780B (en) | 2020-05-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710505828.6A Active CN107334780B (en) | 2017-06-28 | 2017-06-28 | Application of fucoidin in controlling orthodontic tooth movement |
Country Status (1)
| Country | Link |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110301119A1 (en) * | 2008-12-01 | 2011-12-08 | Pukyong National University Industry-Academic Cooperation Foundation | Pharmaceutical compositions containing fucoidan for stimulating and activating osteogenesis |
| CN105833276A (en) * | 2016-06-07 | 2016-08-10 | 付强 | Bone cell LIMK2 gene and novel application of expression products of bone cell LIMK2 gene |
-
2017
- 2017-06-28 CN CN201710505828.6A patent/CN107334780B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110301119A1 (en) * | 2008-12-01 | 2011-12-08 | Pukyong National University Industry-Academic Cooperation Foundation | Pharmaceutical compositions containing fucoidan for stimulating and activating osteogenesis |
| CN105833276A (en) * | 2016-06-07 | 2016-08-10 | 付强 | Bone cell LIMK2 gene and novel application of expression products of bone cell LIMK2 gene |
Non-Patent Citations (1)
| Title |
|---|
| MUNAD J. AL-DULIAMY, ET AL.: "Enhancement of orthodontic anchorage and retention by the local injection of strontium: An experimental study in rats", 《THE SAUDI DENTAL JOURNAL》 * |
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| Publication number | Publication date |
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| CN107334780B (en) | 2020-05-08 |
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