CN107325025A - A kind of chiral alpha amino acid derivativges and preparation method thereof - Google Patents
A kind of chiral alpha amino acid derivativges and preparation method thereof Download PDFInfo
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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Abstract
The invention discloses a kind of chiral alpha amino acid derivativges and preparation method thereof.α chiral amino acid derivatives of the present invention, its structural formula is shown in formula I：
Description
Technical field
The present invention relates to a kind of chiral alpha-amino acid derivatives and preparation method thereof, belong to technical field of organic synthesis.
Background technology
Early 20th century, Mannich et al. has reported first case Mannich reactions, realizes the functionalization of the α positions for N
Process, then obtains broad development on the Mannich reports reacted and application, wherein on the asymmetric method of application
Report until 1997 are realized by Kobayashi by chiral Zr catalyst.Chiral skeleton is realized using Mannich reactions
Structure is then further developed, and is reacted by Mannich be directly realized by α and the amino acid backbone of β among these
To construct be also a kind of new method of synthesis.
Chiral amino acid structure has application widely, can apply to the synthesis of part in organic synthesis, newly matches somebody with somebody
The design of body skeleton.The more extensive part of application often all derives from natural amino acid structure cheap and easy to get at present, and right
In the improvement and design of new ligand backbone, the structure of amino acid certainly will be changed from source, thus for non-natural amino
The synthesis of acid proposes new requirement, and among these, Non-natural chiral amino acid is got growing concern for.
The beginning of this century, chiral small molecule scaffold is built by Asymmetric Catalytic Mannich Reaction and obtains larger development.Its
Middle metal catalytic, by enol path, the asymmetric Mannich reaction development of part regulation and control is more, can be with by this process
It is effectively synthesized a-amino acid skeleton structure.Based on these researchs, organic catalysis has also been developed by enol road strength.It is related in addition
Research in, by organocatalysis enamine path realize efficiently synthesize α-aminoacidesters report it is less.And it is in the majority
The target product obtained in research, often the protection group of amino is still aryl, and this fragrant amine structure is unfavorable uses organic synthesis
In application, it is necessary to further deprotection/protection process so that process is excessively cumbersome, and application is poor.In research in the majority
In, for the report of directly synthesis α-aminoacidesters, only successfully realized by Jocabosen et al. in 2014, it passes through double
The catalysis of function catalyst thiocarbamide is successfully realized the synthesis for α-aminoacidesters, but its catalytic selectivity not yet meets catalysis not
Chiral control requires that reaction is carried out at a lower temperature in the requirement symmetrically synthesized, and its course of reaction, however it remains compared with
Big the drawbacks of.Therefore, green high-efficient is developed, simple organic micromolecule catalyst catalyzes and synthesizes alpha-amido under condition of no solvent
Sour framework compound is significant.
The content of the invention
It is an object of the invention to provide a kind of chiral alpha-amino acid derivatives and preparation method thereof, present invention chirality alpha-amido
Ester compound uses the primary tertiary diamine organic micromolecule catalyst catalysis of the chirality with simple structure, solvent-free, one-step method to close
Into simply, efficiently.
A kind of alpha-chiral amino acid derivativges that the present invention is provided, its structural formula is shown in formula I：
In Formulas I, R1For at least one of hydrogen atom, alkyl substituent and aryl substituent；
R2For at least one of hydrogen atom, halogen atom, alkyl substituent, aryl substituent and aryl amine；And/or,
R1、R2For the cycloalkyl that carbon number is integer between 3~8；
R3For hydrogen atom, alkyl substituent, COR31、COOR32And CONHR33At least one of；R3In, R31For carbon atom
The alkyl and/or phenyl of number 1~5, R32At least one of alkyl, pi-allyl and benzyl for carbon number 1~5, R33To be right
At least one of methoxyphenyl, p-methylphenyl and benzyl；
R4For alkyl substituent, aryl substituent, COOR41、CONHR42、CCl3And CF3At least one of；R4In, R41
For the alkyl and/or benzyl of carbon number 1~5, R42For phenyl, benzyl, p-methoxyphenyl, p-methylphenyl and carbon number
At least one of 1~5 alkyl；
The PG is amino protecting group.
In the present invention, work as R4For COOR41When, as a-amino acid ester compounds.
In above-mentioned derivative, the R1With the R2In, the halogen atom is fluorine, chlorine, bromine, iodine；
The alkyl substituent is C1-C5 saturated alkyl and/or C1-C5 saturated alkyl, concretely propargyl；Institute
It is phenyl, benzyl, rubigan, Chloro-O-Phenyl, p-methoxyphenyl, p-methoxyphenyl and to methylbenzene to state aryl substituent
At least one of base；
The R2In, the aryl amine be anilino-, benzamido group, P-nethoxyaniline base and open-chain crown ether base in extremely
Few one kind；
The R4In, the alkyl substituent is the alkyl of carbon number 1~5, and the aryl substituent is phenyl, to chlorine
At least one of phenyl, p-methoxyphenyl and p-methylphenyl；
The amino protecting group includes tertbutyloxycarbonyl (abbreviation Boc), benzyloxycarbonyl group (abbreviation Cbz), fluorenes methoxycarbonyl
(abbreviation Fmoc), p-toluenesulfonyl (abbreviation Ts), trityl (abbreviation Tr), acetyl group (abbreviation Ac), benzyl (abbreviation Bn),
Phthalimide (English name Benzylideneamine) and trifluoromethyl acetyl group (English name
At least one of Trifluoroacetamide).
Its structural formula of alpha-chiral amino acid derivativges of the present invention is in addition to following formula I -1, Formulas I -2, shown in Formulas I：
Present invention also offers a kind of N, O- acetals, its structural formula is as shown in formula II：
In formula II, PG is amino protecting group, and the amino protecting group includes tertbutyloxycarbonyl, benzyloxycarbonyl group, fluorenes methoxyl group
At least one in carbonyl, p-toluenesulfonyl, trityl, acetyl group, benzyl, phthalyl and trifluoromethyl acetyl group
Kind；
LG is leaving group, and the leaving group is OAc, or at least one of Cl, Br, OMe and OTs；
R4For alkyl substituent, aryl substituent, COOR41、CONHR42、CCl3And CF3At least one of；R4In, R41
For the alkyl and/or benzyl of carbon number 1~5, R42For phenyl, benzyl, p-methoxyphenyl, p-methylphenyl and carbon number
At least one of 1~5 alkyl.
N, the R of O- acetals shown in above-mentioned formula II4In, the alkyl substituent is the alkyl of carbon number 1~5, described
Aryl substituent is at least one of phenyl, rubigan, p-methoxyphenyl and p-methylphenyl.
It is the compound shown in the formula II of the compound of formula II -1 that N of the present invention, O- acetal, which do not include structural formula,.
Present invention also offers the N, the preparation method of O- acetals, including it is following 1) or 2) the step of：
1) it is PGNH by structural formula2Ammonia and structural formula be R4CHO aldehyde mixing, carries out condensation reaction, produces in a solvent
To the N, O- acetals；
2) it is PGNH by structural formula2Ammonia and structural formula be R4CHO aldehyde mixing, carries out half condensation anti-in the solvent
Should, N, O hemiacetal are obtained, then with protection reagent protection hydroxyl, that is, obtain the N, O- acetals；
PG is amino protecting group, and the amino protecting group includes tertbutyloxycarbonyl, benzyloxycarbonyl group, fluorenes methoxycarbonyl, right
At least one of tosyl, trityl, acetyl group, benzyl, phthalyl and trifluoromethyl acetyl group；
R4For hydrogen atom, alkyl substituent, aryl substituent, ester group, amide groups, CCl3And CF3At least one of.
Above-mentioned preparation method 1) or 2) in, the structural formula be PGNH2Ammonia and the structural formula be R4CHO aldehyde rubs
Your ratio can be 1：1.1~1.5, concretely 1:1.3；The solvent is the mixture of acetic acid and acetic anhydride, the acetic acid and institute
The volume ratio for stating acetic anhydride can be 1:1~5, concretely 1:3；
Method 1) in, the temperature of the condensation reaction can be 20~80 DEG C, concretely 60 DEG C, 20~60 DEG C, 60~80
DEG C or 30~70 DEG C, the time can be 1~5 day, concretely 1 day or 1~4 day；
Method 2) in, the temperature of half condensation reaction is 20~80 DEG C, concretely 60 DEG C, 20~60 DEG C, 60~80
DEG C or 30~70 DEG C, the time be 1~5 day, concretely 1 day or 1~4；
The protection reagent is Ac2O, TMSCl, TMSBr, MeOH and Ts2At least one of O；The structural formula is
PGNH2Ammonia with it is described protection reagent mol ratio can be 1：2~20, concretely 1：5、1：5~20 or 1：2~15.
The present invention prepares N, the method for O- acetals, and can improve includes the production of above-mentioned formula II -1 and the compound shown in formula II
Rate.
In the present invention, the N, the preparation method of O- acetals specifically includes following steps：
Method one：With CbzNH2For initiation material, through amine and glyoxylic ester or trichloroacetaldehyde, trifluoro acetaldehyde hemiacetal is condensed
Side chain N, the O- acetal compound of target is obtained, specific synthesis step is：
By CbzNH2(benzyq carbamate), glyoxylic acid ethyl ester press 1：1.1~1.5 mixed in molar ratio, acetic acid, acetic anhydride
With 1:1~5 volume ratio mixing is stirred 1~5 day at 20~80 DEG C as the solvent of reaction, removes unreacted acetic anhydride
And acetic acid is that can obtain the N that side chain Cbz stable accordingly protects amido, O- acetal compounds, specific reaction equation is such as
Shown in Fig. 2；
Method two：Realized by the approach of substep synthesis, first by amine and glyoxylic ester or trichloroacetaldehyde, trifluoro acetaldehyde
The condensation of hemiacetal, obtains N, O hemiacetal, then protects hydroxyl with protection group, and then obtains N, the raw material of O acetal, specifically
Method comprise the following steps that：
By CbzNH2(benzyq carbamate), glyoxylic acid ethyl ester presses 1：1.1~1.5 mixed in molar ratio, in ethyl acetate
In react 1~5 day at 20~80 DEG C, revolving removes solvent, obtains the N of solid, O hemiacetals add 2~20 molar equivalents
Acetic anhydride, the pyridine of 0.1~10% molar equivalent reacts 1~5 day at 20~80 DEG C, removes unreacted acetic anhydride, that is, obtains
The Cbz of side chain protects the N of amido, and O- acetal compounds, specific reaction equation is as shown in Figure 3.
Above-mentioned PG is one kind in Ac, Boc, Fmoc and Ts.
Invention further provides the preparation method of above-mentioned chiralα-aminoacid ester compounds, comprise the following steps：
By carbonyls and the N, the mixture of O- acetals and chiral primary tertiary diamine organic micromolecule catalyst, strong acid and weak acid are mixed
Close, reaction obtains the chiralα-aminoacid compound；
The carbonyls includes aldehyde and/or ketone.
In above-mentioned preparation method, the structural formula of the carbonyls is as shown in following formula 1 or formula 2：
In formula 1 and formula 2, R6For hydrogen atom, alkyl substituent and aryl substituent；R6In, the alkyl substituent is that carbon is former
The alkyl and/or pi-allyl of subnumber 1~5, the aryl substituent are phenyl, rubigan, p-methoxyphenyl and to methyl
At least one of phenyl；
R7For hydrogen atom, alkyl substituent and aryl substituent；R7In, the alkyl substituent is carbon number 1~3
Alkyl, the aryl substituent is at least one of phenyl, benzyl, rubigan and p-methoxyphenyl；
R8For electron-withdrawing group, the electron-withdrawing group is included in ester group, amide groups, acyl group, cyano group, trifluoromethyl and nitro
It is at least one；n2For the integer in 0~5；
In above-mentioned preparation method, the structure such as institute of following formula 3 or 4 of the primary tertiary diamine organic micromolecule catalyst of chirality
Show：
In above-mentioned formula 3 and 4, R4For hydrogen atom, alkyl substituent and aryl substituent, the alkyl substituent is carbon atom
The alkyl of number 1~6, concretely methyl, isopropyl and/or the tert-butyl group, the aryl substituent are benzyl and/or phenyl；R5
For hydrogen atom, alkyl substituent and aryl substituent；The alkyl substituent is the alkyl of carbon number 1~6, concretely first
Base and/or ethyl, the aryl substituent are benzyl and/or phenyl；n1For the integer in 0~9；
R4And R5In, the alkyl substituent is the alkyl that carbon number is 1~6, concretely methyl, isopropyl and/or
The tert-butyl group, the aryl substituent is phenyl and/or benzyl, concretely methyl and/or ethyl.
In the present invention, the structural formula of the primary tertiary diamine organic micromolecule catalyst of chirality is concretely such as following formula 5-1 institutes
Show：
In above-mentioned preparation method, the strong acid includes trifluoroacetic acid, trichloroacetic acid, acetic acid, trifluoromethanesulfonic acid, first sulphur
At least one in acid, benzene sulfonic acid, p-methyl benzenesulfonic acid, tetrafluoro boric acid, four aryl boric acids, hexafluorophosphoric acid, perchloric acid and hypochlorous acid
Kind；
The weak acid includes benzoic acid and/or the benzoic acid with substituent；The benzoic acid with substituent includes naphthalene first
At least one of acid, 2,4- dinitrobenzoic acids, m-Nitrobenzoic Acid and o-nitrobenzoic acid；
The carbonyls and the N, the mol ratio of O- acetals can be 1：0.1~5, concretely 1.2:1 or 1:0.5
~4；
The mol ratio of the primary tertiary diamine organic micromolecule catalyst of chirality and the carbonyls can be 0.5~30：
100, concretely 1:12；
The mol ratio of the primary tertiary diamine organic micromolecule catalyst of chirality, the strong acid and the weak acid can be 1：0.5
~2：0~2, concretely：The mol ratio of the primary tertiary diamine organic micromolecule catalyst of chirality and the strong acid can be 1:1,
The amount of the weak acid is 0；
The temperature of the reaction can be 20 DEG C~100 DEG C, and concretely 60 DEG C, the time can be 1~6 day, concretely 1
My god, 2 days, 1~2 day or 1~5 day；
In the preparation method, in addition to the step of separating-purifying；The method of purification include column chromatography, vacuum distillation and
At least one of recrystallization.
The present invention prepares chiral alpha-amino acid derivatives shown in formula I, including prepares above-mentioned Formulas I -1, shown in Formulas I -2
Compound, can not only improve its yield, more improve its optical selective, obtain optically pure chipal compounds.
The chiral alpha-amino acid derivatives warp that the present invention is synthesized1HNMR、13CNMR is accredited as pure target product.
Chiral alpha-amino acid derivatives of the present invention are applied to the preparation of chiralα-aminoacid, and the chiralα-aminoacid derives
Thing takes off blocking group and can obtain chiralα-aminoacid；
Chiral alpha-amino acid derivatives of the present invention are applied in chiral ligand skeleton is prepared.
The present invention has advantages below：
1st, catalyst structure used in the present invention is simple, and synthetic route is shorter, and synthetic method is simple, easily operated；
2nd, preparation method of the present invention uses one-step synthesis method, greatly reduces synthesis cost and synthesis cycle；
3rd, preparation method of the present invention obtains the optical selective height of product, and obtained target product is optically pure chirality
Amino-acid ester, without further purifying, the operation such as fractionation；
4th, the amount of synthetic method used catalyst involved in the present invention can be reduced to 5mol%, high catalytic efficiency, mapping
Selectivity is good；
5th, the present invention uses solvent-free synthetic method, environmental protection；
6th, method involved in the present invention, which is easy to yield and enantioselectivity after large-scale production, and amplification, to protect
Hold.
Brief description of the drawings
Fig. 1 is the preparation reaction equation of the chiral primary tertiary diamine organic micromolecule catalyst of the present invention.
Fig. 2 is the preparation reaction equation of side chain N, O- acetal in the embodiment of the present invention 1.
Fig. 3 is the preparation reaction equation of side chain N, O- acetal in the embodiment of the present invention 2.
Embodiment
Experimental method used in following embodiments is conventional method unless otherwise specified.
Material, reagent used etc., unless otherwise specified, are commercially obtained in following embodiments.
In following embodiments, the structural formula of chiral primary tertiary diamine organic micromolecule catalyst is concretely such as following formula 5-1 institutes
Show：
The synthetic method of the primary tertiary diamine organic micromolecule catalyst of chirality shown in above-mentioned formula 5-1, is to use S-Leucine
(structural formula is as shown in Equation 7) is initiation material, is made through amido protecting, carboxylic acyloxy amination, deprotection, reduction of amide；It is specific to close
It is as shown in Figure 1 into process；
The specific method of the primary tertiary diamine organic micromolecule catalyst of synthesis of chiral of the present invention, comprises the following steps：
(1) sodium hydroxide, S-Leucine, water are pressed 1:1:10 mol ratio is added in reactor, then will be with uncle L-
(Boc) of leucine equimolar amounts2O is dissolved in 10 times of Isosorbide-5-Nitrae-dioxane, is slowly dropped into reactor, is dripped off rear room temperature and is stirred
Mix 12 hours, the isometric ethyl acetate of the reaction solution after adding and concentrating after concentrated solvent to half adds ethyl acetate
With isometric washing once, solvent is evaporated off in the 4mol/L of volume half hydrochloric acid, point liquid, organic phase after anhydrous sodium sulfate drying
Compound 5 is produced, its structure is as shown in Equation 8；
(2) compound 5 and the dichloromethane dried are pressed 1:10 mol ratio is added in reactor, then under ice-water bath
The dichloromethane solution with the DCC of the equimolar amounts of compound 5 (N, N '-dicyclohexylcarbodiimide) is slowly added dropwise, after dripping off again
Addition and the dimethylamine hydrochloride and triethylamine of the equimolar amounts of compound 5, are stirred at room temperature 12 hours after dripping off, are filtered to remove white
Precipitation, organic phase is used and 2% isometric hydrochloric acid of reaction solution, 4% sodium acid carbonate, saturated common salt water washing, anhydrous slufuric acid respectively
Sodium is evaporated off solvent after drying and produces compound 6, and its structure is as shown in Equation 9；
(3) compound 6 and absolute methanol are pressed 1:10 mol ratio is added in reactor, and compound 6 is then slowly added dropwise
The chloroacetic chloride that 3 times of mole, solvent is evaporated off after being heated to reflux 1 hour, adds the dichloromethane and water isometric with methanol, is used
Watery hydrochloric acid adjusts aqueous pH values to faintly acid (pH value is 6), separates and isometric dichloromethane is added after aqueous phase, then use carbonic acid
Potassium adjusts aqueous pH values to alkalescent, separates and solvent is evaporated off after organic phase, anhydrous sodium sulfate drying produces compound 7, its structure
It is as shown in Equation 10；
(4) compound 7 and the tetrahydrofuran dried are pressed 1:5 mol ratio is added in reactor, then under ice-water bath
The lithium aluminium hydride of 2.5 times of 7 mole of slow compound, room temperature is cooled to after being heated to reflux 4 hours；Tetrahydrochysene is added under ice-water bath
The saturated aqueous sodium sulfate of furans volume half, is filtered to remove precipitation, filtrate with solvent is evaporated off after anhydrous sodium sulfate drying,
Oil pump vacuum distillation is used again, produces the primary tertiary diamine organic micromolecule catalyst (compound 8) of chirality shown in formula 5-1.
Embodiment 1, N, the preparation of O- acetals
Method one：With CbzNH2For initiation material, side chain N, the O- acetalation of target is condensed to yield through amine and glyoxylic ester
Compound, specific synthesis step is：
By CbzNH2(benzyq carbamate), glyoxylic acid ethyl ester press 1：1.3 mixed in molar ratio, acetic acid, acetic anhydride is with 1：3
Volume ratio mixing as the solvent of reaction, stirred 1 day at 60 DEG C, the unreacted acetic anhydride of removing and acetic acid are that can obtain phase
The side chain Cbz for the stabilization answered protects the N of amido, and O- acetal compounds, specific reaction equation is as shown in Figure 2；
Method two：Realized by the approach of substep synthesis, pass through CbzNH first2With the condensation of glyoxylic ester, N, O are obtained
Hemiacetal, then protect hydroxyl with protection group, and then obtain N, the raw material of O acetal, specific method includes following technique step
Suddenly：
By CbzNH2(benzyq carbamate), glyoxylic acid ethyl ester presses 1：1.3 mixed in molar ratio, 60 DEG C in ethyl acetate
Lower reaction 1 day, revolving removes solvent, obtains the N of solid, O hemiacetals add 5 molar equivalents (i.e. 5 times of CbzNH2Rub
Your amount) acetic anhydride, the pyridine of 1% molar equivalent reacts 1 day at 25 DEG C, removes unreacted acetic anhydride, that is, obtain side chain
Cbz protects the N of amido, and O- acetal compounds, specific reaction equation is as shown in Figure 3.
Structural identification is as follows：1H NMR(400MHz,CDCl3) δ 7.34 (s, 5H), 6.36 (s, 1H), 6.25 (d, J=
9.1Hz, 1H), 5.14 (s, 2H), 4.23 (q, J=6.7Hz, 2H), 2.08 (s, 3H), 1.26 (t, J=7.1Hz, 3H)13C
NMR(101MHz,CDCl3)δ170.19,166.31,154.99,135.62,128.58,128.41,128.29,74.59,
67.64,62.65,20.63,13.94.
Embodiment 2, N, the preparation of O- acetals
By CbzNH2(benzyq carbamate), trichloroacetaldehyde presses 1：1.3 mixed in molar ratio, in ethyl acetate at 60 DEG C
Reaction 1 day, revolving removes solvent, obtains the N of solid, O hemiacetals add the acetic anhydride of 5 molar equivalents, 1% molar equivalent
Pyridine, reacted 1 day at 25 DEG C, remove unreacted acetic anhydride, that is, the Cbz for obtaining side chain protects the N of amido, O- acetalations
Compound, specific reaction equation is as shown in Figure 3.
Structural identification is as follows：1H NMR(400MHz,CDCl3) δ 7.37 (s, 5H), 6.93 (d, J=10.0Hz, 1H), 5.69
(s,1H),5.19(s,2H),2.17(s,3H).13C NMR(101MHz,CDCl3)δ168.16,135.51,128.80,
128.72,128.53,98.21,81.38,68.26,20.69.
Embodiment 3, N, the preparation of O- acetals
By CbzNH2(benzyq carbamate), hydration trifluoro acetaldehyde presses 1：1.3 mixed in molar ratio, 60 in ethyl acetate
Reacted 1 day at DEG C, revolving removes solvent, obtains the N of solid, O hemiacetals add the acetic anhydride of 5 molar equivalents, 1% mole
The pyridine of equivalent, reacts 1 day at 25 DEG C, removes unreacted acetic anhydride, that is, the Cbz for obtaining side chain protects the N of amido, O- contractings
Aldehyde compound, specific reaction equation is as shown in Figure 3.
Structural identification is as follows：1H NMR(500MHz,CDCl3) δ 7.35 (q, J=15.0Hz, 5H), 6.80 (s, 1H), 5.66
(d, J=9.0Hz, 1H), 5.17 (d, J=12.0Hz, 2H), 2.14 (s, 3H)13C NMR(126MHz,CDCl3)δ168.09,
154.27,135.26,128.79,128.75,128.53,128.47,122.80,120.57,72.72,72.43,72.14,
71.85,68.32,20.52.
The preparation of embodiment 4, α-aminoacidesters
Prepared according to following reaction equation：
Acetylacetone,2,4-pentanedione (60mmol) and N, O- acetal (50mmol) are added in reactor, then by the chirality shown in formula 5-1
Primary tertiary diamine organic micromolecule catalyst (5.0mmol) is dissolved with 1ml dichloromethane, and trifluoromethanesulfonic acid is instilled under low temperature ice bath
(5.0mmol), is evaporated off after dichloromethane adding this catalyst in reactor, is heated to 60 DEG C, and stirring is reacted after 2 days to be completed,
Pillar layer separation obtains target product α-aminoacidesters 80%, 99%ee.The nuclear magnetic data of its structural identification is as follows：1H NMR
(500MHz,CDCl3) δ 7.34 (dd, J=8.9,6.4Hz, 5H), 5.82 (d, J=9.4Hz, 1H), 5.19-5.03 (m, 2H),
4.99 (dd, J=9.5,4.5Hz, 1H), 4.44 (d, J=4.4Hz, 1H), 4.17 (q, J=7.1Hz, 2H), 2.32 (s, 3H),
2.23 (s, 3H), 1.23 (dd, J=14.5,7.4Hz, 3H)13C NMR(126MHz,CDCl3)δ204.27,203.13,
169.91,156.61,136.14,128.77,128.68,128.36,128.04,67.43,67.14,62.48,52.90,
30.35,30.17,14.07.
The preparation of embodiment 5, α-aminoacidesters
Prepared according to following reaction equation：
2- methyl-acetoacetic acids allyl ester (60mmol) and N, O- acetal (50mmol) are added in reactor, then by formula 5-
The primary tertiary diamine organic micromolecule catalyst (5.0mmol) of chirality shown in 1 is dissolved with 1ml dichloromethane, is instilled under low temperature ice bath
Trifluoromethanesulfonic acid (5.0mmol), is evaporated off after dichloromethane adding this catalyst in reactor, 60 DEG C is heated to, after stirring 2 days
Reaction is completed, and pillar layer separation obtains target product α-aminoacidesters 70%,>99:1dr, 99%ee.The nuclear-magnetism of its structural identification
Data are as follows：1H NMR(500MHz,CDCl3) δ 7.46-7.27 (m, 5H), 5.88 (ddt, J=16.5,10.5,5.9Hz, 1H),
5.46 (d, J=10.1Hz, 1H), 5.38-5.20 (m, 2H), 5.14 (s, 2H), 5.00 (d, J=10.2Hz, 1H), 4.72-
(t, J=7.1Hz, the 3H) of 4.53 (m, 2H), 4.16 (q, J=7.1Hz, 2H), 2.32 (s, 3H), 1.54 (s, 3H), 1.2313C
NMR(126MHz,CDCl3)δ204.12,171.16,170.03,156.73,136.23,131.23,128.69,128.39,
128.19,119.60,67.48,66.61,63.74,62.21,58.34,27.55,19.69,14.02.
The preparation of embodiment 6, α-aminoacidesters
Prepared according to following reaction equation：
Acetone (60mmol) and N, O- acetal (50mmol) are added in reactor, then compound 8 (5.0mmol) is used
1ml dichloromethane is dissolved, and trifluoromethanesulfonic acid (5.0mmol) is instilled under low temperature ice bath, is evaporated off shown in this formula 5-1 after dichloromethane
The primary tertiary diamine organic micromolecule catalyst of chirality add in reactor, be heated to 60 DEG C, reaction completion, post color after stirring 1 day
Compose isolated target product β-carbonylamino acid esters 81%, 99%ee.The nuclear magnetic data of its structural identification is as follows：1H NMR
(400MHz,CDCl3) δ 7.44-7.28 (m, 5H), 5.76 (d, J=8.1Hz, 1H), 5.10 (s, 2H), 4.53 (dt, J=8.5,
4.2Hz, 1H), 4.18 (q, J=7.1Hz, 2H), 3.09 (q, J=89.5,18.3,4.1Hz, 2H), 2.15 (s, 3H), 1.24
(t, J=7.1Hz, 3H)13C NMR(101MHz,CDCl3)δ206.54,171.07,156.20,136.36,128.69,
128.32,128.17,67.14,61.92,50.12,45.36,30.01,14.17.
Same method can synthesize following 1-17 kinds compound：
Yield is 75%,>99:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.40-7.29 (m, 10H), 5.45 (d, J=10.1Hz, 1H), 5.14 (d, J=
11.9Hz, 4H), 5.01 (d, J=10.1Hz, 1H), 4.09 (q, J=7.1Hz, 2H), 2.27 (s, 3H), 1.54 (s, 3H),
1.18 (t, J=7.1Hz, 3H)13C NMR(126MHz,CDCl3)δ204.01,171.24,169.96,156.70,136.22,
134.92,128.77,128.73,128.65,128.59,128.35,128.13,67.79,67.43,63.77,62.17,
58.30,27.51,19.66,13.94.
Yield is 74%,>99:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.41-7.28 (m, 5H), 5.52 (d, J=10.2Hz, 1H), 5.14 (q, J=
12.3Hz, 2H), 4.91 (d, J=10.3Hz, 1H), 4.15 (q, J=7.1Hz, 2H), 2.30 (s, 3H), 1.52 (s, 3H),
1.44 (s, 9H), 1.23 (t, J=7.1Hz, 3H)13C NMR(126MHz,CDCl3)δ205.30,170.36,170.29,
156.71,136.29,128.64,128.33,128.24,83.21,67.37,63.74,61.96,58.35,27.88,27.82,
20.17,14.05.
Yield is 88%,>99:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.39-7.27 (m, 5H), 5.67 (d, J=10.4Hz, 1H), 5.12 (s, 2H),
4.75 (d, J=10.4Hz, 1H), 4.14 (p, J=7.2Hz, 4H), 2.64 (ddd, J=16.5,10.7,6.0Hz, 1H), 2.56
(dt, J=10.4,4.9Hz, 1H), 2.47-2.39 (m, 1H), 2.39-2.29 (m, 1H), 2.01-1.84 (m, 2H), 1.84-
(dt, J=14.3,7.1Hz, the 6H) of 1.71 (m, 1H), 1.62-1.48 (m, 1H), 1.2113C NMR(126MHz,CDCl3)δ
207.72,170.65,170.15,156.49,136.35,128.60,128.28,128.14,67.27,65.12,62.06,
61.91,56.43,40.74,34.21,26.64,22.03,14.03,13.99.
Yield is 81%,>99:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.39-7.27 (m, 5H), 6.09 (d, J=9.3Hz, 1H), 5.11 (s, 2H),
4.99 (d, J=10.0Hz, 1H), 4.23-4.05 (m, 4H), 2.52-2.37 (m, 2H), 2.32 (dt, J=18.9,9.3Hz,
1H), (dt, J=14.2,7.1Hz, the 6H) of 2.20 (dd, J=19.1,11.0Hz, 1H), 2.07-1.86 (m, 2H), 1.2213C
NMR(126MHz,CDCl3)δ213.62,169.87,169.69,155.99,136.29,128.59,128.28,128.22,
67.33,62.15,61.99,61.59,56.38,38.20,31.78,19.52,14.09,14.02.
Yield is 99%, 19:1dr, 92%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.34 (d, J=3.3Hz, 5H), 5.50 (s, 1H), 5.45 (s, 1H), 5.20-
5.03 (m, 2H), 4.99,4.29 (dt, J=10.3,7.0Hz, 2H), 4.24-4.08 (m, 2H), 2.32 (t, J=3.8Hz,
3H),1.37–1.27(m,3H),1.27–1.15(m,3H).13C NMR(126MHz,CDCl3)δ198.56,197.52,
167.20,163.71,163.51,156.05,135.86,128.68,128.46,128.22,128.10,100.32,98.69,
67.84,63.33,62.87,57.39,57.22,26.22,14.01,13.99.
Yield is 75%, 1.08:1dr,>99%ee,>99%ee.Corresponding product nuclear magnetic data is as follows：1H NMR
(500MHz,CDCl3) δ 7.46-7.27 (m, 5H), 5.84 (dd, J=20.7,9.5Hz, 1H), 5.22-5.04 (m, 2H), 4.96
(td, J=10.2,4.5Hz, 1H), 4.30-4.05 (m, 3H), 2.28 (d, J=5.5Hz, 3H), 1.46 (s), 1.41 (s),
(9H),1.29–1.17(m,3H).13C NMR(126MHz,CDCl3)δ203.62,201.49,170.25,169.94,167.29,
166.57,156.36,136.38,136.24,128.67,128.62,128.59,128.28,128.24,128.16,128.07,
83.47,83.19,67.28,67.17,62.21,62.16,61.07,60.53,53.43,52.90,30.20,29.81,
28.36,27.98,27.84,14.14,14.10.
Yield is 99%, 2.54:1dr,>99%ee,>99%ee.Corresponding product nuclear magnetic data is as follows：1H NMR
(500MHz,CDCl3) δ 7.39-7.27 (m, 5H), 5.84 (dd, J=39.0,9.4Hz, 1H), 5.21-5.01 (m, 2H), 4.96
(dt, J=10.9,5.5Hz, 1H), 4.42 (d, J=4.4Hz, 1H), 4.24-4.05 (m, 2H), 2.54-2.32 (m, 2H),
(m, the 6H) of 2.30 (s, 2H), 2.13 (dt, J=13.3,6.7Hz, 1H), 1.22 (t, J=7.1Hz, 3H), 0.98-0.8013C
NMR(126MHz,CDCl3)δ206.21,205.05,204.34,203.07,169.95,156.59,136.17,128.63,
128.30,128.03,127.99,67.34,66.71,66.62,62.40,52.93,52.89,52.00,51.48,30.13,
24.26,22.62,22.37,14.06.
Yield is 67%, 19:1dr,>99%ee,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.40-7.27 (m, 5H), 5.46 (d, J=10.0Hz, 1H), 5.22-5.01 (m,
2H), 4.87 (d, J=10.2Hz, 1H), 4.15 (qd, J=7.1,3.3Hz, 2H), 2.68-2.30 (m, 2H), 2.24 (s, 3H),
(t, J=7.1Hz, the 3H) of 1.61 (s, 3H), 1.22 (t, J=7.1Hz, 3H), 1.0113C NMR(126MHz,CDCl3)δ
210.12,206.74,170.04,156.94,136.17,128.68,128.38,128.35,128.27,128.08,68.68,
67.48,67.06,62.15,57.76,32.55,26.89,18.65,13.99,7.80.
Yield is 67%,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(400MHz,CDCl3) δ 7.40-7.28 (m, 5H), 5.48 (d, J=10.1Hz, 1H), 5.24-5.03 (m,
2H), 4.87 (d, J=10.1Hz, 1H), 4.24-4.05 (m, 2H), 2.25 (s, 3H), 2.20 (s, 3H), 1.61 (s, 3H),
1.21 (t, J=7.1Hz, 3H)13C NMR(101MHz,CDCl3)δ207.48,206.52,169.96,157.00,136.17,
128.68,128.38,128.06,68.79,67.49,62.18,57.56,27.26,26.83,18.91,13.97.
Yield is 85%,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(400MHz,CDCl3) δ 7.40-7.27 (m, 5H), 5.86 (d, J=9.4Hz, 1H), 5.18-5.01 (m,
2H), 4.95 (dd, J=9.4,4.7Hz, 1H), 4.46 (d, J=4.7Hz, 1H), 4.16 (q, J=7.1Hz, 2H), 2.76-
2.56 (m, 2H), 2.55-2.47 (m, 1H), 2.47-2.34 (m, 1H), 1.21 (t, J=7.1Hz, 3H), 1.04 (t, J=
7.2Hz,6H).13C NMR(101MHz,CDCl3)δ207.18,205.83,170.02,156.50,136.24,128.62,
128.27,127.95,67.29,65.24,62.36,53.09,36.29,36.13,14.06,7.58.
Yield is 88%,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(400MHz,CDCl3) δ 7.76 (d, J=7.5Hz, 2H), 7.58 (d, J=7.4Hz, 2H), 7.40 (t, J
=7.4Hz, 2H), 7.32 (t, J=7.4Hz, 2H), 5.90 (d, J=9.5Hz, 1H), 5.02 (dd, J=9.5,4.5Hz, 1H),
4.47 (d, J=4.4Hz, 1H), 4.38 (ddd, J=27.1,10.5,7.5Hz, 2H), 4.21 (dt, J=14.3,7.2Hz,
3H), 2.30 (d, J=29.8Hz, 6H), 1.25 (t, J=7.1Hz, 3H)13C NMR(101MHz,CDCl3)δ204.45,
203.10,169.92,156.58,143.82,143.68,141.41,127.88,127.21,125.22,120.12,67.60,
67.10,62.49,52.86,47.13,30.38,30.14,14.11.
Yield is 87%,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(400MHz,CDCl3) δ 5.53 (d, J=9.3Hz, 1H), 4.92 (dd, J=9.5,4.6Hz, 1H), 4.43
(d, J=4.6Hz, 1H), 4.18 (q, J=7.1Hz, 2H), 2.32 (s, 3H), 2.23 (s, 3H), 1.43 (s, 9H), 1.24 (t, J
=7.1Hz, 3H)13C NMR(101MHz,CDCl3)δ204.32,203.30,170.30,155.99,80.62,67.32,
62.32,52.54,30.36,30.21,28.34,14.11.
Yield is 73%,>19:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.77 (dd, J=7.5,2.8Hz, 2H), 7.59 (d, J=7.5Hz, 2H),
7.45-7.28 (m, 9H), 5.48 (d, J=10.1Hz, 1H), 5.21 (s, 2H), 5.03 (d, J=10.1Hz, 1H), 4.42
(ddd, J=49.1,10.6,7.4Hz, 2H), 4.24 (t, J=7.0Hz, 1H), 4.13 (dd, J=14.0,7.0Hz, 2H),
(t, J=7.1Hz, the 3H) of 2.29 (s, 3H), 1.54 (s, 3H), 1.2113C NMR(126MHz,CDCl3)δ204.11,171.32,
170.01,156.72,143.92,143.71,141.43,134.95,128.82,128.79,128.61,127.88,127.21,
125.17,120.14,120.12,67.84,67.45,63.78,62.23,58.31,47.23,27.55,19.71,14.00.
Yield is 97%,>19:1dr,>99%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.42-7.27 (m, 5H), 5.52 (d, J=10.2Hz, 1H), 5.14 (q, J=
12.3Hz, 2H), 4.91 (d, J=10.3Hz, 1H), 4.15 (q, J=7.1Hz, 2H), 2.30 (s, 3H), 1.52 (s, 3H),
1.44 (s, 9H), 1.23 (t, J=7.1Hz, 3H)13C NMR(126MHz,CDCl3)δ205.30,170.36,170.29,
156.71,136.29,128.64,128.33,128.24,83.21,67.37,63.74,61.96,58.35,27.88,27.82,
20.17,14.05.
Yield is 99%, anti/syn=59:41,98%/70%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 7.40-7.28 (m, 5H), 5.83,5.44 (d, J=8.1Hz, 1H), 5.20-
5.03 (m, 2H), 4.81-4.57 (m, 1H), 4.34-4.04 (m, 2H), 2.92 (t, J=8.4Hz, 1H), 2.68-2.44 (m,
1H), 2.31 (dd, J=17.3,7.9Hz, 1H), 2.26-2.11 (m, 1H), 2.11-1.96 (m, 1H), 1.96-1.72 (m,
2H),1.36–1.15(m,3H).13C NMR(126MHz,CDCl3)δ217.64,171.06,170.78,156.61,136.35,
136.29,128.67,128.64,128.35,128.32,128.26,128.20,67.05,62.03,53.47,53.13,
51.91,51.12,38.19,37.91,26.18,20.76,20.51,14.20.
Yield is 78%, anti/syn=84:16,95%/98%ee.Corresponding product nuclear magnetic data is as follows：1H NMR
(400MHz,CDCl3) δ 7.42-7.27 (m, 5H), 5.62 (d, J=10.0Hz, 1H), 5.22-5.01 (m, 2H), 4.35 (dd, J
=10.1,3.1Hz, 1H), 4.24-4.04 (m, 2H), 3.39-3.15,2.85-2.70, (m, 1H), 2.46-2.21 (m, 2H),
(t, J=7.1Hz, the 3H) of 2.21-1.99 (m, 2H), 1.92 (d, J=12.2Hz, 1H), 1.84-1.48 (m, 3H), 1.2313C
NMR(101MHz,CDCl3)δ211.69,171.20,157.15,136.47,128.62,128.22,128.04,67.13,
61.72,54.49,53.05,42.02,30.81,27.31,26.93,24.86,14.16.
Yield is 68%, 91%ee.Corresponding product nuclear magnetic data is as follows：
1H NMR(500MHz,CDCl3) δ 9.55 (s, 1H), 7.41-7.28 (m, 5H), 5.50 (d, J=9.4Hz, 1H),
5.12 (t, J=8.0Hz, 2H), 4.55 (d, J=9.6Hz, 1H), 4.17 (q, J=7.1Hz, 2H), 1.96 (d, J=14.2Hz,
1H), 1.87-1.79 (m, 1H), 1.75 (dt, J=25.0,9.7Hz, 1H), 1.71-1.42 (m, 5H), 1.42-1.29 (m,
2H), 1.26 (dd, J=15.2,8.0Hz, 3H), 1.21-1.13 (m, 1H)13C NMR(126MHz,CDCl3)δ204.32,
170.16,156.30,136.11,128.65,128.38,128.24,67.44,61.94,58.18,52.52,28.57,
27.57,25.18,22.11,22.06,14.16。
Claims (10)
1. a kind of alpha-chiral amino acid derivativges, its structural formula is shown in formula I：
In Formulas I, R1For at least one of hydrogen atom, alkyl substituent and aryl substituent；
R2For at least one of hydrogen atom, halogen atom, alkyl substituent, aryl substituent and aryl amine；And/or, R1、R2
For the cycloalkyl that carbon number is integer between 3~8；
R3For hydrogen atom, alkyl substituent, COR31、COOR32And CONHR33At least one of；R3In, R31For carbon number 1~
5 alkyl and/or phenyl, R32At least one of alkyl, pi-allyl and benzyl for carbon number 1~5, R33For to methoxy
At least one of base phenyl, p-methylphenyl and benzyl；
R4For alkyl substituent, aryl substituent, COOR41、CONHR42、CCl3And CF3At least one of；R4In, R41It is former for carbon
The alkyl and/or benzyl of subnumber 1~5, R42For phenyl, benzyl, p-methoxyphenyl, p-methylphenyl and carbon number 1~5
At least one of alkyl；
The PG is amino protecting group.
2. derivative according to claim 1, it is characterised in that：The R1With the R2In, the halogen atom be fluorine,
Chlorine, bromine, iodine；
The alkyl substituent is C1-C5 saturated alkyl and/or C1-C5 saturated alkyl；The aryl substituent be phenyl,
At least one of benzyl, rubigan, Chloro-O-Phenyl, p-methoxyphenyl, p-methoxyphenyl and p-methylphenyl；
The R2In, the aryl amine is at least one in anilino-, benzamido group, P-nethoxyaniline base and open-chain crown ether base
Kind；
The R4In, the alkyl substituent be carbon number 1~5 alkyl, the aryl substituent be phenyl, rubigan,
At least one of p-methoxyphenyl and p-methylphenyl
The amino protecting group include tertbutyloxycarbonyl, benzyloxycarbonyl group, fluorenes methoxycarbonyl, p-toluenesulfonyl, trityl,
At least one of acetyl group, benzyl, phthalimide and trifluoromethyl acetyl group.
3. a kind of N, O- acetal, its structural formula is as shown in formula II：
In formula II, PG is amino protecting group, and the amino protecting group includes tertbutyloxycarbonyl, benzyloxycarbonyl group, fluorenes methoxyl group carbonyl
At least one in base, p-toluenesulfonyl, trityl, acetyl group, benzyl, phthalyl and trifluoromethyl acetyl group
Kind；
LG is leaving group, and the leaving group includes at least one of OAc, Cl, Br, OMe and OTs；
R4For alkyl substituent, aryl substituent, COOR41、CONHR42、CCl3And CF3At least one of；R4In, R41It is former for carbon
The alkyl and/or benzyl of subnumber 1~5, R42For phenyl, benzyl, p-methoxyphenyl, p-methylphenyl and carbon number 1~5
At least one of alkyl.
4. N according to claim 3, O- acetal, it is characterised in that：The R of the formula II4In, the alkyl substituent is carbon
The alkyl of atomicity 1~5, the aryl substituent be phenyl, rubigan, p-methoxyphenyl and p-methylphenyl in extremely
Few one kind.
5. the preparation method of N described in claim 3 or 4, O- acetal, including it is following 1) or 2) the step of：
1) it is PGNH by structural formula2Ammonia and structural formula be R4CHO aldehyde mixing, carries out condensation reaction, that is, obtains institute in a solvent
State N, O- acetals；
2) it is PGNH by structural formula2Ammonia and structural formula be R4CHO aldehyde mixing, half condensation reaction is carried out in the solvent, is obtained
To N, O hemiacetal, then with protection reagent protection hydroxyl, that is, obtain the N, O- acetals；
PG is amino protecting group, the amino protecting group include tertbutyloxycarbonyl, benzyloxycarbonyl group, fluorenes methoxycarbonyl, to toluene
At least one of sulfonyl, trityl, acetyl group, benzyl, phthalyl and trifluoromethyl acetyl group；
R4For hydrogen atom, alkyl substituent, aryl substituent, ester group, amide groups, CCl3And CF3At least one of.
6. preparation method according to claim 5, it is characterised in that：It is above-mentioned 1) or 2) in, the structural formula is PGNH2Ammonia
It is R with the structural formula9The mol ratio of CHO aldehyde is 1：1.1~1.5；The solvent is the mixture of acetic acid and acetic anhydride, institute
The volume ratio for stating acetic acid and the acetic anhydride is 1:1~5；
Method 1) in, the temperature of the condensation reaction is 20~80 DEG C, and the time is 1~5 day；
Method 2) in, the temperature of half condensation reaction is 20~80 DEG C, and the time is 1~5 day；
The protection reagent is Ac2O, TMSCl, TMSBr, MeOH and Ts2At least one of O；The structural formula is PGNH2's
The mol ratio of ammonia and the protection reagent is 1：2~20.
7. the preparation method of the chiralα-aminoacid ester compounds described in claim 1 or 2, comprises the following steps：Will carbonylation
Compound and N described in claim 3 or 4, the mixture of O- acetals and chiral primary tertiary diamine organic micromolecule catalyst, strong acid and weak
Acid mixing, reaction obtains the chiralα-aminoacid compound；
The carbonyls includes aldehyde and/or ketone.
8. preparation method according to claim 7, it is characterised in that：The structural formula of the carbonyls such as following formula 1 or
Shown in formula 2：
In formula 1 and formula 2, R6For hydrogen atom, alkyl substituent and aryl substituent；R6In, the alkyl substituent is carbon number
1~5 alkyl and/or pi-allyl, the aryl substituent is phenyl, rubigan, p-methoxyphenyl and p-methylphenyl
At least one of；
R7For hydrogen atom, alkyl substituent and aryl substituent；R7In, the alkyl substituent is the alkyl of carbon number 1~3,
The aryl substituent is at least one of phenyl, benzyl, rubigan and p-methoxyphenyl；
R8For electron-withdrawing group, the electron-withdrawing group is included in ester group, amide groups, acyl group, cyano group, trifluoromethyl and nitro at least
It is a kind of；n2For the integer in 0~5.
9. the preparation method according to claim 7 or 8, it is characterised in that：The primary tertiary diamine organic molecule of chirality is urged
The structure of agent is as shown in following formula 3 or 4：
In above-mentioned formula 3 and 4, R4For hydrogen atom, alkyl substituent and aryl substituent, the alkyl substituent be carbon number 1~
6 alkyl；R5For any one in hydrogen atom, alkyl substituent and aryl substituent；n1For the integer in 0~9；
R4And R5In, the alkyl substituent is the alkyl that carbon number is 1~6, and the aryl substituent is phenyl and/or benzyl
Base.
10. the preparation method according to any one of claim 7-9, it is characterised in that：The strong acid include trifluoroacetic acid,
Trichloroacetic acid, acetic acid, trifluoromethanesulfonic acid, methanesulfonic acid, benzene sulfonic acid, p-methyl benzenesulfonic acid, tetrafluoro boric acid, four aryl boric acids, hexafluoro
At least one of phosphoric acid, perchloric acid and hypochlorous acid；
The weak acid includes benzoic acid and/or the benzoic acid with substituent；The benzoic acid with substituent includes naphthoic acid, 2,
At least one of 4- dinitrobenzoic acids, m-Nitrobenzoic Acid and o-nitrobenzoic acid；
The carbonyls and the N, the mol ratio of O- acetals is 1：1~5；
The mol ratio of the primary tertiary diamine organic micromolecule catalyst of chirality and the carbonyls is 0.5~30：100；
The mol ratio of the primary tertiary diamine organic micromolecule catalyst of chirality, the strong acid and the weak acid is 1：0.5~2：0~
2；
The temperature of the reaction is 20 DEG C~100 DEG C, and the time is 1~6 day；
In the preparation method, in addition to the step of separating-purifying；The method of purification includes column chromatography, vacuum distillation and tied again
At least one of crystalline substance.
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| CN108299242A (en) * | 2018-03-12 | 2018-07-20 | 中国科学院化学研究所 | A kind of preparation method of chirality trifluoromethyl amine derivative |
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| WO2006081151A1 (en) * | 2005-01-24 | 2006-08-03 | Merck & Co., Inc. | Process to chiral beta amino acid derivatives by asymmetric hydrogenation |
| CN103553931A (en) * | 2013-10-24 | 2014-02-05 | 中国科学院化学研究所 | Method for synthesizing chiral diketone compound |
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| WO2006081151A1 (en) * | 2005-01-24 | 2006-08-03 | Merck & Co., Inc. | Process to chiral beta amino acid derivatives by asymmetric hydrogenation |
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| CN108299242A (en) * | 2018-03-12 | 2018-07-20 | 中国科学院化学研究所 | A kind of preparation method of chirality trifluoromethyl amine derivative |
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