CN107308250A - It is a kind of to treat pill of the protrasion of the lumbar intervertebral disci and preparation method thereof - Google Patents
It is a kind of to treat pill of the protrasion of the lumbar intervertebral disci and preparation method thereof Download PDFInfo
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- CN107308250A CN107308250A CN201710408624.0A CN201710408624A CN107308250A CN 107308250 A CN107308250 A CN 107308250A CN 201710408624 A CN201710408624 A CN 201710408624A CN 107308250 A CN107308250 A CN 107308250A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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Abstract
The invention discloses a kind of pill for treating the protrasion of the lumbar intervertebral disci, it is made up of the raw material components of following several weights:10 18 parts of 15 30 parts of Ligusticum wallichii, 20 35 parts of golden cypress, 20 30 parts of the root of herbaceous peony, 10 20 parts of the bighead atractylodes rhizome and the fruit of glossy privet.In the present invention, the basic theory of traditional Chinese medicine is used, by above raw material components compatibility, cooperated with each other between raw material, produce regulation body equilibrium between yin and yang, promoting blood circulation qi-regulating, conditioning viscera, improve body microcirculation, stimulate the circulation of the blood and cause the muscles and joints to relax, the effect of anti-inflammatory analgetic, reach the purpose for fundamentally treating the protrasion of the lumbar intervertebral disci.Result is proved through clinical usage, and the present invention is notable to treatment Lumbar Intervertebral Disc.
Description
Technical field
The present invention relates to the drug therapy field of orthopaedics disease, more particularly, to a kind of protrasion of the lumbar intervertebral disci for the treatment of
Pill and preparation method thereof.
Background technology
The protrasion of the lumbar intervertebral disci, also known as Annulus Fibrosus of Lumbar Intervertebral Discs rupture disease, or lumber ertebral disc core herniation.Lumber ertebral disc is dashed forward
It is that lumber ertebral disc exchange protrudes and causes vertebral disease to go out disease, and spinal canal stenosis surrounding soft tissue is viscous, even damage, and blood circulation subtracts
Slowly, the lumbocrural pain symptom that hypoxic-ischemic is oppressed pars lumbalis medullae spinalis nerve root and occurred.Protrusion of lumber intervertebral disc is fibrous ring destruction institute
Cause, be lumber ertebral disc rupture disease.
Caused by the morbidity of protrusion of lumber intervertebral disc is due to the regression hyperplasia of lumbar vertebrae, the regression of lumbar vertebrae is one and is gradually in progress
Physiology or pathologic process, therefore the age is an influence factor.In the degenerative processes of lumbar vertebrae, except being presented with interverbebral disc
Regression, stenosis of disc space, outside the osteoproliferation of centrum front and rear edge and articular process, capsular ligament, ligament around it are also sent out accordingly
Raw hyperemia, swelling, fibrosis, calcification or a series of change such as ossify, thus stimulate and oppress neck lumbar nerve roots, spinal cord or
Neck sympathetic nerve, vertebral artery etc. are organized, and can cause a variety of clinical manifestations.
The method of clinical treatment protrusion of lumber intervertebral disc has operative treatment and non-operative treatment, and operative treatment is mainly for tight
Lattice expectant treatment is invalid or expectant treatment effectively, but often recurrence and pain is compared with severe one;Typically it is not recommended that using operative treatment.
Non-operative treatment mainly includes drug therapy and non-drug therapy, and non-drug therapy is such as lain up, massaged, medicine
The methods such as thing, traction, massage, acupuncture, closing, are primarily suitable for initial or lighter state of an illness case.Its therapy purpose promotes to protrude
Position Hui Na, improves blood circulation, and increase intervertenral space is stimulated with the compressing mitigated to nerve root, is eliminated because protrusion oppresses god
Through caused oedema, inflammation, respite symptom, but this therapy is substantially that thoroughly can not eliminate and return to receive prominent vertebra
Disk.
Drug therapy includes treatment by Chinese herbs and western medicine, though western medicine can slow down the pain of patient to a certain extent
Pain and inflammation, but index do not effect a permanent cure, and side effect is larger.
The content of the invention
To overcome existing technological deficiency, prepared the invention provides one kind using Chinese herbal medicine, cost is relatively low and curative effect is aobvious
The pill of the treatment protrasion of the lumbar intervertebral disci of work.
To realize the purpose of the present invention, it is achieved using following technical scheme:
A kind of pill for treating the protrasion of the lumbar intervertebral disci, is made up of the raw material components of following several weights:Ligusticum wallichii 15-30
10-18 parts of part, 20-35 parts of golden cypress, 20-30 parts of the root of herbaceous peony, 10-20 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
Preferably, being made up of the raw material components of following several weights:20-25 parts of Ligusticum wallichii, 25-30 parts of golden cypress,
12-16 parts of 23-27 parts of the root of herbaceous peony, 13-17 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
Preferably, being made up of the raw material components of following several weights:23 parts of Ligusticum wallichii, 28 parts of golden cypress, the root of herbaceous peony 25
14 parts of part, 15 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
A kind of to be applied to a kind of above-mentioned preparation method for the pill for treating the protrasion of the lumbar intervertebral disci, its preparation process is:
S1:Above-mentioned each raw material components are weighed according to weight, dries, is put into a clean container, addition does not have after cleaning
Cross the yellow rice wine of 2-5 centimetres of raw material height, sealing immersion 30 days;
S2:The raw material soaked is poured out, filters, raw material is separated with filtrate, then will be pulverized after raw material fried dry, sieves, obtains
Pulvis;
S3:The honey that weight is 80 parts is added in pulvis, the filtrate being filtrated to get in step S2 is added, is prepared into
Pill, 8 grams are weighed per ball, then are dried, and are encapsulated.
The pharmacology and efficacy effect that above-mentioned each raw material components have are as follows:Ligusticum wallichii has promote breath and open depression, and method wind-dryness is wet, promoting blood circulation
The effect of analgesic;There is golden cypress antibacterial, antimycotic, convergence anti-inflammatory, diuresis, stomach invigorating, external application to promote the effects such as subcutaneous hemorrhage absorbs;
The bighead atractylodes rhizome has tonifying middle-Jiao and Qi, and strengthening the spleen and stomach, eliminate dampness and have diuretic effect, antiemetic rushes down, hidroschesis, the effect of antiabortive;The root of herbaceous peony, which has to enrich blood, holds back the moon, puts down
The effect of liver relieves pain;The effect of fruit of glossy privet has nourishing liver and kidney, strong waist and knee, bright knowledge, black beard and hair.
Chinese medicine is the rarity of the Chinese nation, from ancient times to the present, and traditional Chinese medicine is that human health is made that huge contribution.China is
The most country of traditional Chinese medicine is studied, Basic Theories of Chinese Medicine explains the healthy mechanism of people's body from every side.In the present invention,
The basic theory of traditional Chinese medicine has been used, above raw material components compatibility has cooperated with each other between raw material, regulation body negative and positive has been produced and puts down
Weighing apparatus, promoting blood circulation qi-regulating, conditioning viscera, improve body microcirculation, stimulate the circulation of the blood and cause the muscles and joints to relax, the effect of anti-inflammatory analgetic, reach and fundamentally treat
The purpose of the protrasion of the lumbar intervertebral disci.Result is proved through clinical usage, and the present invention is notable to treatment Lumbar Intervertebral Disc.
Compared with the prior art, the invention has the advantages that:
(1)The present invention carries out compatibility using Ligusticum wallichii, golden cypress, the root of herbaceous peony, the bighead atractylodes rhizome and the fruit of glossy privet, and the pill being made has regulation body cloudy
Rising tone weighing apparatus, promoting blood circulation qi-regulating, conditioning viscera, improve body microcirculation, stimulate the circulation of the blood and cause the muscles and joints to relax, the effect of anti-inflammatory analgetic so that fundamentally
Treat the protrasion of the lumbar intervertebral disci.
(2)Medicine material of the present invention is common drug, and each raw material components meet the regulation of pharmaceutical control law, and each
There is sale in big pharmacy, has no toxic side effect, raw material is easy to get and cost is relatively low.
(3)The present invention first uses the active ingredient in each raw material components of restricted-access media, then by each raw material components and effectively
Composition is prepared by mixing into pill administration, with convenient to take, taste good and effect evident in efficacy.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, the present invention is made into one with reference to specific embodiment
Step is explained.
Embodiment 1
A kind of pill for treating the protrasion of the lumbar intervertebral disci, is made up of the raw material components of following several weights:23 parts of Ligusticum wallichii,
14 parts of 28 parts of golden cypress, 25 parts of the root of herbaceous peony, 15 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
Its preparation method is as follows:
S1:Above-mentioned each raw material components are weighed according to weight, dries, is put into a clean container, addition does not have after cleaning
Cross the yellow rice wine of 3 centimetres of raw material height, sealing immersion 30 days;
S2:The raw material soaked is poured out, filters, raw material is separated with filtrate, then will be pulverized after raw material fried dry, sieves, obtains
Pulvis;
S3:The honey that weight is 80 parts is added in pulvis, the filtrate being filtrated to get in step S2 is added, using system
Pill prepared by the machine of standby pill, 8 grams are weighed per ball, then are dried, and are encapsulated.
Embodiment 2
A kind of pill for treating the protrasion of the lumbar intervertebral disci, is made up of the raw material components of following several weights:15 parts of Ligusticum wallichii,
10 parts of 20 parts of golden cypress, 20 parts of the root of herbaceous peony, 10 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
Its preparation method be the same as Example 1.
Embodiment 3
A kind of pill for treating the protrasion of the lumbar intervertebral disci, is made up of the raw material components of following several weights:30 parts of Ligusticum wallichii,
18 parts of 35 parts of golden cypress, 30 parts of the root of herbaceous peony, 20 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
Its preparation method be the same as Example 1.
The toxicity of embodiment 4 is tested
With the pertinent regulations according to study of tcm new drug, toxicity is carried out to embodiment 1, embodiment 2 and the pills for implementing 3 preparations
Test.
Choice experiment animal and packet:10 monthly age Adult male rats 40 are selected first, 4 groups are divided into, and are respectively
Experimental group 1, experimental group 2, experimental group 3 and contrast groups 4, every group 10, every group is individually raised.
Adaptability is raised:Experiment first carries out 5 days adaptability before starting and raised.After adaptability is raised within 5 days, each group rat is deposited
Living, adaptability is good.
Toxicity test experiments method:Example 1, embodiment 2 and each one of pill made from embodiment 3, grind respectively
Fine powder is worn into, in the feed for being added to its corresponding experimental group 1, experimental group 2 and the rat of experimental group 3, the feed of the rat of contrast groups 4
In, it is added without any medicament.Continuous raising checks the health of rat after 30 days, 30 days.
Toxicity result:After 30 days, without a rats death.Check in the health of rat, the body of each group rat
Find no toxin residual.Illustrate that the obtained pill of the present invention has no toxic side effect.
The clinical testing procedure of embodiment 5
Further to investigate the clinical efficacy of the drug therapy protrasion of the lumbar intervertebral disci of the present invention, 300 protrusion of lumber intervertebral disc are selected
Disease patient has carried out clinical observation on the therapeutic effect.
Selection crowd and packet:Clinically 300 cases it will be randomly divided into 3 groups, respectively test group 1, test group 2 and examination
Test group 3, every group of 100 people.Wherein all cases meet《Disease of tcm Standardization of diagnosis and curative effect》In on the protrasion of the lumbar intervertebral disci
Standard:1st, there are waist wound, chronic strain or by cold-dampness history, most of patient has chronic back pain history in premorbid;2nd, Chang Fa
It is born in person between twenty and fifty;3rd, pain in the back is radiated to buttocks and lower limb, and pain is aggravated when abdominal pressure increase, such as cough, sneeze;4th, scoliosis,
Lumbar vertebrae physiologic radian disappears, and has tenderness sense by diseased region vertebra, and radiated to lower limb, waist limitation of activity;5th, lower limb involvement god
Felt allergy or blunt through dominating area, course of disease elder may occur in which muscular atrophy, leg raising straight or to strengthen experiment positive, knee, with
Tendon reflex weakens or disappeared, and big toe dorsiflexion power weakens;6th, x ray photograph inspection:Scoliosis, waist physiology lordosis disappears, lesion vertebra
Disk may narrow, and neighboring edge has osteophytosis, and CT examination can show disc herniation position and degree.
Treatment method:Test group 1 takes pill made from embodiment 1;Test group 2 takes pill made from embodiment 2;It is real
Test group 3 and take pill made from embodiment 3.Twice daily, every time 1, take within 1 hour after the meal sooner or later, two weeks is a treatment
Journey, the state of an illness takes the 1-2 course for the treatment of compared with the lighter, and the state of an illness takes the 2-3 course for the treatment of compared with severe one.
Criterion of therapeutical effect:Reference《Disease of tcm judges criterion of therapeutical effect》In relevant criterion of therapeutical effect.Recovery from illness:Clinical symptoms all disappear
Lose, laboratory checks normal.Take a turn for the better:Clinical symptom relief, laboratory examination improves or normal.It is invalid:Clinical symptoms are without obvious
Take a turn for the better or aggravate.
The treatment results of embodiment 1:In 100 cases for receiving this treatment, there are 32 recoveries from illness, 59 improvements, 9 nothings
Effect.Total effective rate is up to 91%.
The treatment results of embodiment 2:In 100 cases for receiving this treatment, there are 30 recoveries from illness, 58 improvements, 12 nothings
Effect.Total effective rate is 89%.
The treatment results of embodiment 3:In 100 cases for receiving this treatment, there are 31 recoveries from illness, 60 improvements, 9 nothings
Effect.Total effective rate is up to 91%.
To sum up, pill of the invention has a significant curative effect to the treatment protrasion of the lumbar intervertebral disci, and total effective rate is up to more than 89%.
Model case:
Case 1:It is deep certain, man, 65 years old, peasant, August is gone to a doctor on the 23rd within 2016, and flank pain is more than 3 years, nearly 2 years aggravations,
Sometimes evening pain must can't fall asleep, in Zeng villages Branch Clinic repeatedly diagnose it is invalid, after go to Urban Hospitals go to a doctor, take medicine a couple of days
Interior energy slows down symptom, but the state of an illness can recur again later.It is medical to our hospital later, after diagnosing:L4-L5, L5-S1 interverbebral disc are dashed forward
Go out;L2, L3, L4, L5 centrum are loose with osteoproliferation;Waist yellow ligament thickening.3 courses for the treatment of of pill of the present invention, disease are taken afterwards
Feelings are clearly better, and waist can only ache a little once in a while, after continue to take 2 courses for the treatment of of pill of the present invention, the state of an illness has been completely recovered,
No recurrence is visited after half a year.
Case 2:Chen, female, 46 years old, teacher, in March, 2016 must not walk because of lumbocrural pain, waist limitation of activity, backbone side
Curved, waist physiology radians disappear, and have tenderness, x ray photograph inspection by diseased region vertebra:Scoliosis, waist physiology lordosis disappears, lesion
Interverbebral disc narrows, and neighboring edge has osteophytosis;The protrasion of the lumbar intervertebral disci is diagnosed as, two 4 courses for the treatment of of medicine of the present invention are taken,
Pain disappears, and x ray photograph checks that symptom disappears, rear to take 1 course for the treatment of after treatment of medicine of the present invention again, and follow-up is not multiple so far
Hair.
Claims (4)
1. a kind of pill for treating the protrasion of the lumbar intervertebral disci, it is characterised in that by the raw material components of following several weights
It is made:10-18 parts of 15-30 parts of Ligusticum wallichii, 20-35 parts of golden cypress, 20-30 parts of the root of herbaceous peony, 10-20 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
2. a kind of pill for treating the protrasion of the lumbar intervertebral disci according to claim 1, it is characterised in that by following several heavy
The raw material components of amount part proportioning are made:20-25 parts of Ligusticum wallichii, 25-30 parts of golden cypress, 23-27 parts of the root of herbaceous peony, 13-17 parts of the bighead atractylodes rhizome and glossy privet
It is sub- 12-16 parts.
3. a kind of pill for treating the protrasion of the lumbar intervertebral disci according to claim 2, it is characterised in that by following several heavy
The raw material components of amount part proportioning are made:14 parts of 23 parts of Ligusticum wallichii, 28 parts of golden cypress, 25 parts of the root of herbaceous peony, 15 parts of the bighead atractylodes rhizome and the fruit of glossy privet.
4. a kind of a kind of preparation side of pill for treating the protrasion of the lumbar intervertebral disci suitable for described in any one of claims 1 to 3
Method, it is characterised in that its preparation process is:
S1:Above-mentioned each raw material components are weighed according to weight, dries, is put into a clean container, addition does not have after cleaning
Cross the yellow rice wine of 2-5 centimetres of raw material height, sealing immersion 30 days;
S2:The raw material soaked is poured out, filters, raw material is separated with filtrate, then will be pulverized after raw material fried dry, sieves, obtains
Pulvis;
S3:The honey that weight is 80 parts is added in pulvis, the filtrate being filtrated to get in step S2 is added, is prepared into
Pill, 8 grams are weighed per ball, then are dried, and are encapsulated.
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CN201710408624.0A CN107308250A (en) | 2017-06-02 | 2017-06-02 | It is a kind of to treat pill of the protrasion of the lumbar intervertebral disci and preparation method thereof |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1136949A (en) * | 1996-05-07 | 1996-12-04 | 王富云 | Chinese medicine 'Yiqizhuangdu' pill for supplementing qi and strengthening Du Channel |
CN104887899A (en) * | 2014-03-08 | 2015-09-09 | 寇彩琴 | Compound prepared rehmannia root-radix achyranthis bidentatae pill |
-
2017
- 2017-06-02 CN CN201710408624.0A patent/CN107308250A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1136949A (en) * | 1996-05-07 | 1996-12-04 | 王富云 | Chinese medicine 'Yiqizhuangdu' pill for supplementing qi and strengthening Du Channel |
CN104887899A (en) * | 2014-03-08 | 2015-09-09 | 寇彩琴 | Compound prepared rehmannia root-radix achyranthis bidentatae pill |
Non-Patent Citations (1)
Title |
---|
邓晋丰等: "治疗腰椎间盘突出症一八六例临床观察", 《新中医》 * |
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