CN107308117A - A kind of Tilmicosin pre-mixing agent and preparation method thereof - Google Patents
A kind of Tilmicosin pre-mixing agent and preparation method thereof Download PDFInfo
- Publication number
- CN107308117A CN107308117A CN201710532601.0A CN201710532601A CN107308117A CN 107308117 A CN107308117 A CN 107308117A CN 201710532601 A CN201710532601 A CN 201710532601A CN 107308117 A CN107308117 A CN 107308117A
- Authority
- CN
- China
- Prior art keywords
- tilmicosin
- mixing agent
- polyglutamic acid
- pul
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2377/00—Characterised by the use of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Derivatives of such polymers
- C08J2377/04—Polyamides derived from alpha-amino carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
It is as made from the raw material of following parts by weight the invention discloses a kind of Tilmicosin pre-mixing agent：10 40 parts of Tilmicosin, 15 25 parts of Pul polyglutamic acid cross-linked polymer, 5 10 parts of starch, 20 40 parts of DEXTROSE ANHYDROUS.The invention also discloses the preparation method of the Tilmicosin pre-mixing agent.The Tilmicosin pre-mixing agent of the present invention is in the presence of Pul polyglutamic acid cross-linked polymer, the uncomfortable bitter taste of Tilmicosin and excitant can not only be covered, increase palatability, its bioavilability can also be improved, the stability of medicine is greatly improved, and stimulation of the reduction to stomach, so that feed intake of the ill domestic animal to medicine is effectively ensured.The preparation method of the present invention is simple, safe.
Description
Technical field
The present invention relates to livestock and poultry pharmaceutical arts, and in particular to a kind of Tilmicosin pre-mixing agent and preparation method thereof.
Background technology
Antibiotic has the meaning of milestone as the great discovery of mankind's development in science and technology in biology and medical domain.
Since being come out from penicillin in 1940, various synthesis and semisynthetic antibiotics emerge in an endless stream, strong as the guarantee mankind and animals and plants
The important weapon of health.Research and application of the people to antibiotic are more and more extensive, in animal diseases control, improve feed conversion
Important function has been played in terms of rate, promotion growth of animals or poultry.
Tilmicosin (Timicosin) is the semi-synthetic special antibiosis of macrolides livestock and poultry of 1980s exploitation
Element, molecular weight 869.15.By tylosin and 3,5- lupetidines reaction generation Tilmicosin alkali, then phosphorate sour and water i.e.
Tilmicosin phosphate is formed, it is the mixture of cis-trans-isomer.Tilmicosin is to carry out aldehyde after research tylosin desugar
The good product of activity that the aminating reaction of base is obtained, the aminating reaction uses anti-with the Wallach of first acid as catalyst
Should, yield very high Tilmicosin can be obtained.Tilmicosin as a kind of special antibiotic of livestock and poultry, to gram-positive bacteria, certain
A little Gram-negative bacteria, mycoplasma, conveyor screws etc. have inhibitory action；Have pleuropneumonia actinomyces, Pasteurella than Thailand
The stronger antibacterial activity of happy rhzomorph.It is mainly used in preventing and treating domestic animal pneumonia (by Actinobacillus pleuropneumoniae, Pasteurella, mycoplasma
Cause Deng infection), avian mycoplasmas disease and lactating mammal mastitis.
But Tilmicosin forbids intravenous, Niu Yici intravenous 5mg/kg can be lethal, and pig, horse and primate are also easily caused
Extremely, the target organ of its toxic action is heart, can cause negativity mental and physical efforts effect.And due to Tilmicosin taste extremely hardship and to stomach and intestine
The excitant in road, can cause the apocleisis of livestock and poultry, and the symptom such as nausea and vomiting, animal takes extremely difficult, has had a strong impact on for rice
Examine the use of star.Accordingly, it would be desirable to which bad smell and irritating tilmicosin micro-capsule preparation can effectively be sheltered to reduce for rice by researching and developing
The use limitation of star is examined, the producing level of the medicine is improved.
The content of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of Tilmicosin pre-mixing agent and preparation method thereof, the present invention
Not only composition is simple, safe for the product of preparation, and masks the uncomfortable bitter taste of Tilmicosin and excitant in pre-mixing agent,
The stimulation of the stability and reduction of medicine to stomach is greatly improved, so that feed intake of the ill domestic animal to medicine is effectively ensured.
What technique effect of the present invention was realized by following technical solution：
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：10-40 parts of Tilmicosin, short stalk are mould
Polysaccharide -15-25 parts of polyglutamic acid cross-linked polymer, 5-10 parts of starch, 20-40 parts of DEXTROSE ANHYDROUS.
Described, Pul-polyglutamic acid cross-linked polymer is as made from following methods：Pul is molten
Liquid is added drop-wise in polyglutamic acid solution with 5 drops/s speed, stirring reaction 2h under the conditions of 30 DEG C, absolute ethyl alcohol precipitation mixed liquor,
Vacuum filtration collects precipitation, by precipitation deionized water dissolving, is placed in bag filter the 2h that dialyses, and it is dry that dialysis is retained into liquid freezing
It is dry, obtain Pul-polyglutamic acid cross-linked polymer.
Described, the mass ratio of polyglutamic acid solution and Pul solution is 1：1.
Described, the concentration of Pul solution is 6mg/ml, and pH is 4.0.
Described, the concentration of polyglutamic acid solution is 60mg/ml, and pH is 4.5.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Pul-polyglutamic acid cross-linked polymer is added in liquid material, stirred, added Tilmicosin and stir
20min is mixed, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 60-80：1.
Described, heating-up temperature is 60-70 DEG C.
Beneficial effects of the present invention：The Tilmicosin pre-mixing agent of the present invention is in Pul-polyglutamic acid cross-linked polymeric
In the presence of thing, the uncomfortable bitter taste of Tilmicosin and excitant can be not only covered, increases palatability, it can also be improved biological
Availability, is greatly improved the stability of medicine, and reduces the stimulation to stomach, so that feeding of the ill domestic animal to medicine is effectively ensured
Amount.The preparation method of the present invention is simple, safe.
Embodiment
With reference to embodiment, the present invention will be further described.
Raw material used in the present invention is market purchase gained.
Embodiment 1
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：10 parts of Tilmicosin, short stalk are mould more
Sugar -25 parts of polyglutamic acid cross-linked polymer, 10 parts of starch, 40 parts of DEXTROSE ANHYDROUS.
Described, Pul-polyglutamic acid cross-linked polymer is as made from following methods：Pul is molten
Liquid is added drop-wise in polyglutamic acid solution with 5 drops/s speed, stirring reaction 2h under the conditions of 30 DEG C, absolute ethyl alcohol precipitation mixed liquor,
Vacuum filtration collects precipitation, by precipitation deionized water dissolving, is placed in bag filter the 2h that dialyses, and it is dry that dialysis is retained into liquid freezing
It is dry, obtain Pul-polyglutamic acid cross-linked polymer.
Described, the mass ratio of polyglutamic acid solution and Pul solution is 1：1.
Described, the concentration of Pul solution is 6mg/ml, and pH is 4.0.
Described, the concentration of polyglutamic acid solution is 60mg/ml, and pH is 4.5.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Pul-polyglutamic acid cross-linked polymer is added in liquid material, stirred, added Tilmicosin and stir
20min is mixed, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 60：1.
Described, heating-up temperature is 70 DEG C.
Embodiment 2
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：25 parts of Tilmicosin, short stalk are mould more
Sugar -20 parts of polyglutamic acid cross-linked polymer, 8 parts of starch, 30 parts of DEXTROSE ANHYDROUS.
Described, Pul-polyglutamic acid cross-linked polymer is as made from following methods：Pul is molten
Liquid is added drop-wise in polyglutamic acid solution with 5 drops/s speed, stirring reaction 2h under the conditions of 30 DEG C, absolute ethyl alcohol precipitation mixed liquor,
Vacuum filtration collects precipitation, by precipitation deionized water dissolving, is placed in bag filter the 2h that dialyses, and it is dry that dialysis is retained into liquid freezing
It is dry, obtain Pul-polyglutamic acid cross-linked polymer.
Described, the mass ratio of polyglutamic acid solution and Pul solution is 1：1.
Described, the concentration of Pul solution is 6mg/ml, and pH is 4.0.
Described, the concentration of polyglutamic acid solution is 60mg/ml, and pH is 4.5.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Pul-polyglutamic acid cross-linked polymer is added in liquid material, stirred, added Tilmicosin and stir
20min is mixed, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 70：1.
Described, heating-up temperature is 65 DEG C.
Embodiment 3
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：40 parts of Tilmicosin, short stalk are mould more
Sugar -15 parts of polyglutamic acid cross-linked polymer, 5 parts of starch, 20 parts of DEXTROSE ANHYDROUS.
Described, Pul-polyglutamic acid cross-linked polymer is as made from following methods：Pul is molten
Liquid is added drop-wise in polyglutamic acid solution with 5 drops/s speed, stirring reaction 2h under the conditions of 30 DEG C, absolute ethyl alcohol precipitation mixed liquor,
Vacuum filtration collects precipitation, by precipitation deionized water dissolving, is placed in bag filter the 2h that dialyses, and it is dry that dialysis is retained into liquid freezing
It is dry, obtain Pul-polyglutamic acid cross-linked polymer.
Described, the mass ratio of polyglutamic acid solution and Pul solution is 1：1.
Described, the concentration of Pul solution is 6mg/ml, and pH is 4.0.
Described, the concentration of polyglutamic acid solution is 60mg/ml, and pH is 4.5.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Pul-polyglutamic acid cross-linked polymer is added in liquid material, stirred, added Tilmicosin and stir
20min is mixed, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 80：1.
Described, heating-up temperature is 60 DEG C.
Comparative example 1
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：25 parts of Tilmicosin, 8 parts of starch, nothing
30 parts of water glucose.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Tilmicosin is stirred into 20min, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 70：1.
Described, heating-up temperature is 65 DEG C.
Comparative example 2
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：25 parts of Tilmicosin, Pul
20 parts, 8 parts of starch, 30 parts of DEXTROSE ANHYDROUS.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) Pul is added in liquid material, stirred, added Tilmicosin stirring 20min, be made after softwood
Granulation, is dried, and is sieved through sieve with No. 4, is obtained mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 70：1.
Described, heating-up temperature is 65 DEG C.
Comparative example 3
A kind of Tilmicosin pre-mixing agent, is as made from the raw material of following parts by weight：25 parts of Tilmicosin, polyglutamic acid 20
Part, 8 parts of starch, 30 parts of DEXTROSE ANHYDROUS.
A kind of preparation method of Tilmicosin pre-mixing agent, is as made from following steps：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid
Material；
2) polyglutamic acid is added in liquid material, stirred, added Tilmicosin stirring 20min, be made after softwood and make
Grain, is dried, and is sieved through sieve with No. 4, is obtained mixture；
3) mixture is sampled detection, after detection is qualified, product packed, that is, obtain Tilmicosin premix
Agent.
Described, the weight ratio of water and starch is 70：1.
Described, heating-up temperature is 65 DEG C.
The effect of clinical testing treatment swine enzootic pneumonia
Select Junan County pig farm market pig 1520,95 ages in days or so, wherein there are 215 to occur coughing and pant.With
Machine selects wherein 140, is randomly divided into 7 groups, every group 20.
Test method：Experimental group 1-3 adds the Tilmicosin pre-mixing agent of embodiment 1-3 preparations respectively, per 1000kg feeds
Add 1.5kg Tilmicosin pre-mixing agent.Control group 1-3 adds the Tilmicosin pre-mixing agent of comparative example 1-3 preparations respectively, often
1000kg feeds add 1.5kg Tilmicosin pre-mixing agent.Blank control group is only given chow diet, without any medicine.
The above-mentioned equal continuous use of experimental animal 7 days, is observed 5 days again after medication, and observation clinical symptoms and death condition, dynamic to dying of illness daily
Thing carries out cut open inspection.Calculate the effective percentage, cure rate, Relapse rate situation of each group.Result of the test is as shown in table 1.
Chow diet component is：Corn, soya-bean cake, rice bran, bone meal, egg-shell meal, whey powder, dregs of beans and premix.
Criterion：
Cure：Clinical symptom disappearance in 7 days after drug withdrawal (cough and asthma stop, and spirit takes a turn for the better, growth recovery is normal etc.).
Effectively：Clinical symptom relief (cough and asthma or mitigation, spirit take a turn for the better, and growth takes a turn for the better etc.).
It is invalid：It is unchanged or aggravate or dead or disease relapse in (including after drug withdrawal in 7 days) clinical symptoms during testing.
The Tilmicosin pre-mixing agent of table 1 treats the effect of swine enzootic pneumonia
| Group | Total head number | Cure head number | Effective head number | Invalid head number | Cure rate | Total effective rate |
| Experimental group 1 | 20 | 16 | 3 | 1 | 80% | 95% |
| Experimental group 2 | 20 | 15 | 5 | 0 | 75% | 100% |
| Experimental group 3 | 20 | 15 | 4 | 1 | 75% | 95% |
| Control group 1 | 20 | 9 | 2 | 9 | 45% | 55% |
| Control group 2 | 20 | 8 | 2 | 10 | 40% | 50% |
| Control group 3 | 20 | 10 | 1 | 9 | 50% | 55% |
| Blank control group | 20 | 0 | 0 | 20 | 0 | 100% |
As shown in Table 1, the cure rate and total effective rate of Tilmicosin pre-mixing agent prepared by 1-3 of the embodiment of the present invention are far above
Control group and blank control group, significant difference.
Returned in process of the test now, the feed intake and feeding effect of experimental group 1-3 pigs are substantially better than control group, with blank pair
It is suitable according to group, illustrate that the palatability of Tilmicosin pre-mixing agent prepared by the present invention is good.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. a kind of Tilmicosin pre-mixing agent, it is characterised in that be as made from the raw material of following parts by weight：Tilmicosin 10-40
Part, Pul -15-25 parts of polyglutamic acid cross-linked polymer, 5-10 parts of starch, 20-40 parts of DEXTROSE ANHYDROUS.
2. Tilmicosin pre-mixing agent according to claim 1, it is characterised in that the Pul-polyglutamic acid is handed over
Linked polymer is as made from following methods：Pul solution is added drop-wise in polyglutamic acid solution with 5 drops/s speed,
Stirring reaction 2h under the conditions of 30 DEG C, absolute ethyl alcohol precipitation mixed liquor, vacuum filtration collects precipitation, and precipitation is molten with deionized water
Solution, is placed in bag filter the 2h that dialyses, and dialysis is retained into liquid freeze-drying, Pul-polyglutamic acid cross-linked polymer is obtained.
3. Tilmicosin pre-mixing agent according to claim 2, it is characterised in that the polyglutamic acid solution and short stalk are mould more
The mass ratio of sugar juice is 1：1.
4. Tilmicosin pre-mixing agent according to claim 2, it is characterised in that the concentration of the Pul solution is
6mg/ml, pH are 4.0.
5. Tilmicosin pre-mixing agent according to claim 2, it is characterised in that the concentration of the polyglutamic acid solution is
60mg/ml, pH are 4.5.
6. the preparation method of Tilmicosin pre-mixing agent any one of a kind of claim 1-5, it is characterised in that be by following
Made from step：
1) starch and DEXTROSE ANHYDROUS are added into distilled water, is heated to whole dissolvings, be cooled to room temperature after stirring, obtain liquid material；
2) Pul-polyglutamic acid cross-linked polymer is added in liquid material, stirred, add Tilmicosin stirring
20min, is made after softwood and pelletizes, dry, be sieved through sieve with No. 4, obtain mixture；
3) mixture is sampled detection, after detection is qualified, product is packed, that is, obtains Tilmicosin pre-mixing agent.
7. preparation method according to claim 6, it is characterised in that the weight ratio of the water and starch is 60-80：1.
8. preparation method according to claim 6, it is characterised in that the heating-up temperature is 60-70 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710532601.0A CN107308117A (en) | 2017-07-03 | 2017-07-03 | A kind of Tilmicosin pre-mixing agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710532601.0A CN107308117A (en) | 2017-07-03 | 2017-07-03 | A kind of Tilmicosin pre-mixing agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107308117A true CN107308117A (en) | 2017-11-03 |
Family
ID=60181092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710532601.0A Pending CN107308117A (en) | 2017-07-03 | 2017-07-03 | A kind of Tilmicosin pre-mixing agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107308117A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553450A (en) * | 2018-06-24 | 2018-09-21 | 王琴 | A kind of Tilmicosin pill and preparation method thereof |
| CN109717447A (en) * | 2019-03-14 | 2019-05-07 | 山东省海洋化工科学研究院 | A kind of sustained release edible salt and preparation method thereof |
| CN110025575A (en) * | 2019-05-24 | 2019-07-19 | 安徽奥力欣生物科技有限公司 | A kind of Tilmicosin mixed micelle soluble powder and preparation method thereof |
| CN111281980A (en) * | 2020-02-05 | 2020-06-16 | 石家庄学院 | Water-soluble gamma-polyglutamic acid-tilmicosin compound and preparation method thereof |
| CN112843011A (en) * | 2021-02-04 | 2021-05-28 | 广州市和生堂动物药业有限公司 | Tilmicosin premix and preparation method thereof |
| CN114712313A (en) * | 2021-11-26 | 2022-07-08 | 湖南佳锐思生物科技有限公司 | Method for preparing efficient tilmicosin premix through adsorption crystallization and application of efficient tilmicosin premix |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670516A (en) * | 2012-05-29 | 2012-09-19 | 广东大华农动物保健品股份有限公司 | Tilmicosin soluble powder and preparation method thereof |
| CN104171433A (en) * | 2014-08-21 | 2014-12-03 | 广东腾骏动物药业股份有限公司 | Soluble tilmicosin premix and preparation method thereof |
| CN104222265A (en) * | 2014-09-09 | 2014-12-24 | 曲阜师范大学 | Complex preservative and application thereof in fruit and vegetable preservation |
| CN104940147A (en) * | 2015-06-29 | 2015-09-30 | 湖南泰谷生物科技股份有限公司 | Tilmicosin premix and preparation method thereof |
| CN105708810A (en) * | 2016-03-28 | 2016-06-29 | 宁波科瑞特动物药业有限公司 | Tilmicosin premix with fragrance and preparation method of tilmicosin premix |
| CN106389391A (en) * | 2016-09-18 | 2017-02-15 | 天津北洋百川生物技术有限公司 | Novel drug dosage suitable for children and preparation method thereof |
-
2017
- 2017-07-03 CN CN201710532601.0A patent/CN107308117A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670516A (en) * | 2012-05-29 | 2012-09-19 | 广东大华农动物保健品股份有限公司 | Tilmicosin soluble powder and preparation method thereof |
| CN104171433A (en) * | 2014-08-21 | 2014-12-03 | 广东腾骏动物药业股份有限公司 | Soluble tilmicosin premix and preparation method thereof |
| CN104222265A (en) * | 2014-09-09 | 2014-12-24 | 曲阜师范大学 | Complex preservative and application thereof in fruit and vegetable preservation |
| CN104940147A (en) * | 2015-06-29 | 2015-09-30 | 湖南泰谷生物科技股份有限公司 | Tilmicosin premix and preparation method thereof |
| CN105708810A (en) * | 2016-03-28 | 2016-06-29 | 宁波科瑞特动物药业有限公司 | Tilmicosin premix with fragrance and preparation method of tilmicosin premix |
| CN106389391A (en) * | 2016-09-18 | 2017-02-15 | 天津北洋百川生物技术有限公司 | Novel drug dosage suitable for children and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵萍主编: "《粮油食品工艺》", 30 November 2004, 甘肃科学技术出版社 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553450A (en) * | 2018-06-24 | 2018-09-21 | 王琴 | A kind of Tilmicosin pill and preparation method thereof |
| CN109717447A (en) * | 2019-03-14 | 2019-05-07 | 山东省海洋化工科学研究院 | A kind of sustained release edible salt and preparation method thereof |
| CN109717447B (en) * | 2019-03-14 | 2022-06-07 | 山东省海洋化工科学研究院 | Slow-release edible salt and preparation method thereof |
| CN110025575A (en) * | 2019-05-24 | 2019-07-19 | 安徽奥力欣生物科技有限公司 | A kind of Tilmicosin mixed micelle soluble powder and preparation method thereof |
| CN111281980A (en) * | 2020-02-05 | 2020-06-16 | 石家庄学院 | Water-soluble gamma-polyglutamic acid-tilmicosin compound and preparation method thereof |
| CN112843011A (en) * | 2021-02-04 | 2021-05-28 | 广州市和生堂动物药业有限公司 | Tilmicosin premix and preparation method thereof |
| CN112843011B (en) * | 2021-02-04 | 2021-10-15 | 广州市和生堂动物药业有限公司 | Tilmicosin premix and preparation method thereof |
| CN114712313A (en) * | 2021-11-26 | 2022-07-08 | 湖南佳锐思生物科技有限公司 | Method for preparing efficient tilmicosin premix through adsorption crystallization and application of efficient tilmicosin premix |
| CN114712313B (en) * | 2021-11-26 | 2023-09-22 | 湖南湘农动物药业有限公司 | Method for preparing efficient tilmicosin premix by adsorption crystallization and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107308117A (en) | A kind of Tilmicosin pre-mixing agent and preparation method thereof | |
| KR20200003993A (en) | Antimicrobial composition comprising the leaf extract of polygonium ticnctorium and use thereof | |
| CN107648326B (en) | Preparation method of amaranth yellow dysentery-stopping oral liquid for livestock | |
| CN104171433B (en) | A kind of solubility Tilmicosin pre-mixing agent and preparation method thereof | |
| CN101991640A (en) | Preparation method of mahonia fortune-containing Chinese medicinal composition and application thereof | |
| CN101417018B (en) | Preparation method of animal injection capable of clearing away the heat-evil and expelling superficial evils, cooling blood and relieving dysentery | |
| CN106620668A (en) | Compound tilmicosin solid dispersing agent and preparation method thereof | |
| CN103524448A (en) | Enrofloxacin-saccharin compound | |
| CN105012304B (en) | A kind of compound florfenicol composition | |
| CN107970272A (en) | The purposes of pithecellobium clypearia or extract in treatment and/or the bronchopneumonic medicine of auxiliary treatment livestock and poultry is prepared | |
| CN106362159A (en) | Molecular skeleton type tilmicosin sustained release preparation and preparation method thereof | |
| CN112843011A (en) | Tilmicosin premix and preparation method thereof | |
| CN101829129A (en) | Veterinary compound gentamycin sulfate injection and preparation method thereof | |
| CN1985838A (en) | Lung-targeting tylan microsphere for animal and birds and its preparing method | |
| CN105796499B (en) | A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof | |
| CN116036188B (en) | Traditional Chinese medicine composition for preventing and treating chicken coccidiosis as well as preparation method and application thereof | |
| CN117379467B (en) | Pharmaceutical composition for treating digestive tract diseases and preparation method thereof | |
| CN110025575A (en) | A kind of Tilmicosin mixed micelle soluble powder and preparation method thereof | |
| CN102293867B (en) | Compound stellera chamae jasme linn. preparation for animals, and preparation method thereof | |
| CN110179758B (en) | Crystalline valnemulin hydrochloride soluble powder capable of being administered by drinking water and application thereof | |
| CN107998264A (en) | A kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease and preparation method and application | |
| CN109481491B (en) | Myrobalan composition and application thereof in preparation of products for preventing and/or treating porcine respiratory diseases | |
| RU2687041C1 (en) | Biopreparation for cows endometritis prevention and treatment | |
| CN110237113A (en) | A kind of plant extracts additive and the application of anti-Escherichia coli and coccidia mixed infection | |
| CN106902147B (en) | Sophora flavescens powder and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171103 |