CN107308103A - One kind can wide variety of Chinese herbal medicine jelly preparation method - Google Patents
One kind can wide variety of Chinese herbal medicine jelly preparation method Download PDFInfo
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- CN107308103A CN107308103A CN201710564557.1A CN201710564557A CN107308103A CN 107308103 A CN107308103 A CN 107308103A CN 201710564557 A CN201710564557 A CN 201710564557A CN 107308103 A CN107308103 A CN 107308103A
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- wax
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- 235000015110 jellies Nutrition 0.000 title claims abstract description 46
- 239000008274 jelly Substances 0.000 title claims abstract description 46
- 241000411851 herbal medicine Species 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 58
- 239000006187 pill Substances 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 238000003756 stirring Methods 0.000 claims abstract description 16
- 238000009835 boiling Methods 0.000 claims abstract description 12
- 239000000084 colloidal system Substances 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 229920001817 Agar Polymers 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 7
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 7
- 239000008272 agar Substances 0.000 claims abstract description 7
- 238000010410 dusting Methods 0.000 claims abstract description 7
- 239000008273 gelatin Substances 0.000 claims abstract description 7
- 229920000159 gelatin Polymers 0.000 claims abstract description 7
- 235000019322 gelatine Nutrition 0.000 claims abstract description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 7
- 229940013618 stevioside Drugs 0.000 claims abstract description 7
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019202 steviosides Nutrition 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000002674 ointment Substances 0.000 claims abstract description 5
- 230000008961 swelling Effects 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 235000005979 Citrus limon Nutrition 0.000 claims description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 239000001993 wax Substances 0.000 claims description 6
- 235000013871 bee wax Nutrition 0.000 claims description 5
- 239000012166 beeswax Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 238000010790 dilution Methods 0.000 claims description 4
- 239000012895 dilution Substances 0.000 claims description 4
- 244000248349 Citrus limon Species 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 235000019640 taste Nutrition 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 9
- 244000131522 Citrus pyriformis Species 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229940116229 borneol Drugs 0.000 description 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- 241000205585 Aquilegia canadensis Species 0.000 description 2
- 241000576429 Forsythia suspensa Species 0.000 description 2
- 244000131316 Panax pseudoginseng Species 0.000 description 2
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 2
- 240000007164 Salvia officinalis Species 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000005412 red sage Nutrition 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- -1 borneol compound Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
One kind can wide variety of Chinese herbal medicine jelly preparation method, it is characterized in that comprising the following steps：Step 1）Make wax-wrapped pill：Chinese medicine pilling machine for wax pills is used, Chinese medicine is played into powder, dusting cover, 2.5-3.0mm of diameter water pill, ointment ball or condensed pill is made, then by drying, waxdip, wax-wrapped pill is made, it is standby；Step 2）Make jelly liquid：By gelatin, agar, water according to 1:1:8 mixing, soak 20-30 minutes, make its abundant water swelling；Then, it is sufficiently mixed with refiner, homogenate is made；Then, stirring at low speed and boiling is heated to, keeps slight boiling condition, be continuously added distilled water, maintain overall solution volume, until colloid dissolving is complete, 0.4% -0.6% stevioside is added immediately, is stirred, natural cooling；The present invention is in good taste, and it masks the bad smell of volatile ingredient in medicine, is taken medicine using children's jelly form loved by all, adds interesting and edibility, beneficial to taking.
Description
Technical field
Can wide variety of Chinese herbal medicine jelly preparation method the present invention relates to technical field of pharmaceuticals, especially one kind.
Background technology
For thousands of years, the mouthfeel of Chinese medicine is poor, generally very bitter, and especially children, sense of taste sensitive subjects are more difficult receives, although
Good medicine tastes bitter, but new technology it is highly developed today Chinese medicine mouthfeel still without remarkable improvement, in govern to a certain extent
Medicine is popularized.
The content of the invention
Can wide variety of Chinese herbal medicine jelly preparation method, the master that the present invention is intended to solve it is an object of the invention to provide one kind
It is optimization Chinese medicine manufacture craft to want problem, by the modern manufacturing technology such as medicine pill, the conventional fabrication techniques of paste and jelly
It is combined, on the premise of Chinese Herbs and security is ensured, improves medicine mouthfeel, promote application in TCM prospect.It is mainly used in
Chinese medicine manufacture craft is improved, improves Chinese medicine mouthfeel.
The technical scheme is that：
One kind can wide variety of Chinese herbal medicine jelly preparation method, it is characterized in that comprising the following steps：
Step 1）Make wax-wrapped pill：
Chinese medicine pilling machine for wax pills is used, Chinese medicine is played into powder, dusting cover, 2.5-3.0mm of diameter water pill, ointment ball or concentration is made
Ball, then by drying, waxdip, wax-wrapped pill is made, it is standby；
Step 2）Make jelly liquid：
By gelatin, agar, water according to 1:1:8 mixing, soak 20-30 minutes, make its abundant water swelling；Then, refiner is used
It is sufficiently mixed, homogenate is made；Then, stirring at low speed and be heated to boiling, keep slight boiling condition, be continuously added distilled water, maintain
Overall solution volume, until colloid dissolving is complete, adds 0.4% -0.6% stevioside, stirs immediately, natural cooling；
Step 3）Prepare Chinese herbal medicine jelly：
When obtained jelly liquid naturally cools to 70 DEG C -80 DEG C in step 2, concentrated lemon juice, citric acid are sequentially added, is filled
Divide stirring mixing, add Chinese medicine wax-wrapped pill made from the step 1 during to 50 DEG C -65 DEG C, slowly stir evenly, Chinese herbal medicine jelly is made, point
Dress, radiosterilization, less than 20 DEG C preservations.
Chinese medicine is broken into 500-1000 mesh powders in the step 1.
Waxdip is answered when waxdip makes in the step 1 fully, uniformly, it is ensured that internal layer medicine does not exosmose.
Colloid composition should be acidified when jelly liquid doses dense lemon juice, citric acid in the step 3, maintain certain dilution
Degree.
It should prevent wax-wrapped pill from dissolving when jelly liquid is mixed with Chinese medicine wax-wrapped pill in the step 3, can do degreasing to beeswax if necessary
Processing, to improve fusing point.
The beneficial effects of the invention are as follows：
The present invention is in good taste, and it masks the bad smell of volatile ingredient in medicine, using the jelly shape that children are loved by all
Formula is taken medicine, and is added interesting and edibility, beneficial to taking, has thoroughly been broken away from the dislike mood taken to Chinese medicine.
The present invention can wide variety of Chinese herbal medicine jelly preparation method can be widely used for Chinese patent drug, the making of hospital-made medicine
Process, improves Chinese medicine mouthfeel, promotes the application of Chinese medicine；The present invention can wide variety of Chinese herbal medicine jelly preparation method avoid Chinese medicine
Composition is directly contacted with the external world, reduces the unfavorable factors such as contaminated, oxidation deterioration, is easy to storage, is extended the shelf life.
The present invention can wide variety of Chinese herbal medicine jelly preparation method can reach according to Formulation it is quick-acting, long-acting, efficient；
Controllable insoluble drug release position and multipath administration（Orally, sublingual, cavity etc.）；Equipment is simple, non-dusting.
The present invention has the characteristics of surface area is big, dissolution rate is fast so that the active constituent content of Chinese medicine is high, its maximum limit
Degree extracts and remains volatile effective component, can improve the bioavilability of insoluble drug.Because the small wax-wrapped pill of Chinese medicine is
The solid dispersions of formation, medicine exists with small particle, therefore sublingual administration direct oral cavity mucosal absorption, is directly entered blood and follows
Ring, 3min works, and can delay rapidly；Administration number of times is reduced, convenient administration improves the compliance of sufferer medication；
The present invention enters stomach and intestine, and disintegration is absorbed by the body rapidly, reaches effective blood drug concentration and effective and special composition makes
Obtain blood concentration steady, it is to avoid or reduce the toxic side effect that peak valley phenomenon advantageously reduces medicine；Total agent of medication can be reduced
Amount, can reach maximum drug effect with minimum dose.The medicine of the present invention is in selective distribution（Targeting distribution）.With slow releasing pharmaceutical and
Extend the effect of medicine time in vivo, improve the stability of medicine.
Embodiment
With reference to embodiment, the invention will be further described：
Material：All kinds of parts of generic medicinal plants, beeswax etc., water, agar, gelatin, stevioside, concentrated lemon juice, citric acid etc..
1. equipment：Chinese medicine pilling-machine for wax pills, refiner.
2. preparation method：
Step 1）：Make wax-wrapped pill：With Chinese medicine pilling-machine for wax pills, Chinese medicine is played into powder, dusting cover, 2.5-3.0mm of diameter water is made
General ball（Or ointment ball, or condensed pill）, drying, wax-wrapped pill is made in waxdip, standby.
Step 2）：Make jelly liquid：By gelatin, agar, water according to 1:1:8 mixing, soak 20-30 minutes, make its abundant
Water swelling；Then, it is sufficiently mixed with refiner, homogenate is made；Then, stirring at low speed and be heated to boiling, keep micro-boiling shape
State, is continuously added distilled water, maintains overall solution volume, until colloid dissolving is complete, 0.4% -0.6% stevioside is added immediately, is stirred
Mix uniform, natural cooling.
Step 3）：Prepare Chinese herbal medicine jelly：When jelly liquid naturally cools to 75 DEG C or so, appropriate concentration lemon is sequentially added
Juice, citric acid, are thoroughly mixed, and to Chinese medicine wax-wrapped pill is added at 60 DEG C or so, slowly stir evenly, Chinese herbal medicine jelly is made, and dispense, spoke
Penetrate sterilization, less than 20 DEG C preservations.
Wax-wrapped pill diameter should be controlled in smaller range, be easy to swallow；Wax-wrapped pill answers waxdip fully, uniformly when making, it is ensured that internal layer
Medicine does not exosmose；Jelly liquid should be acidified colloid composition when dosing dense lemon juice, citric acid in higher temperature, maintain necessarily
Dilution factor；Jelly liquid should be completed when being mixed with Chinese medicine wax-wrapped pill in lower temperature, prevent wax-wrapped pill from dissolving, and can do suitable to beeswax if necessary
When ungrease treatment, to improve fusing point.
Embodiment one.
[prescription] radix scutellariae, honeysuckle, the capsule of weeping forsythia
[preparation] step 1）：Make wax-wrapped pill：With Chinese medicine pilling-machine for wax pills, radix scutellariae, honeysuckle, the capsule of weeping forsythia are played into powder, dusting cover, are made
Diameter 2.5mm ointment ball, drying, wax-wrapped pill is made in waxdip, standby.
Step 2）：Make jelly liquid：By gelatin, agar, water according to 1:1:8 mixing, soak 25 minutes, it is fully absorbed water
Expansion；Then, it is sufficiently mixed with refiner, homogenate is made；Then, stirring at low speed and be heated to boiling, keep slight boiling condition, no
It is disconnected to add distilled water, overall solution volume is maintained, until colloid dissolving is complete, 0.5% stevioside is added immediately, is stirred, it is natural
Cooling.
Step 3）：Prepare Chinese herbal medicine jelly：When jelly liquid naturally cools to 75 DEG C, sequentially add appropriate concentrated lemon juice,
Citric acid, is thoroughly mixed, and to Chinese medicine wax-wrapped pill is added at 60 DEG C, slowly stirs evenly, Chinese herbal medicine jelly is made, and dispenses, radiosterilization,
Less than 20 DEG C preservations.
[function is with curing mainly] is clearing heat and detoxicating, clear preferably wind-heat, for heating, cough, abscess of throat caused by affection of exogenous wind-heat.
Suitable for the viral and bacterial infection of the upper respiratory tract, pneumonia, tonsillitis, pharyngitis etc..
Embodiment two.
[prescription] Salvia miltiorrhiza and Panax notoginseng borneol
[preparation] step 1）：Make wax-wrapped pill：With Chinese medicine pilling-machine for wax pills, the red sage root, pseudo-ginseng, borneol are played into powder, dusting cover, are made straight
Footpath 2.5mm water pill, drying, wax-wrapped pill is made in waxdip, standby.
Step 2）：Make jelly liquid：By gelatin, agar, water according to 1:1:8 mixing, soak 20-30 minutes, make its abundant
Water swelling；Then, it is sufficiently mixed with refiner, homogenate is made；Then, stirring at low speed and be heated to boiling, keep micro-boiling shape
State, is continuously added distilled water, maintains overall solution volume, until colloid dissolving is complete, 0.6% stevioside is added immediately, stirring is equal
It is even, natural cooling.
Step 3）：Prepare Chinese herbal medicine jelly：When jelly liquid naturally cools to 70 DEG C, sequentially add appropriate concentrated lemon juice,
Citric acid, is thoroughly mixed, and to Chinese medicine wax-wrapped pill is added at 60 DEG C, slowly stirs evenly, Chinese herbal medicine jelly is made, and dispenses, radiosterilization,
Less than 20 DEG C preservations.
The red sage root, pseudo-ginseng, borneol compound preparation, the treatment available for angiocardiopathy especially coronary heart diseases and angina pectoris etc..
Wax-wrapped pill diameter should be controlled in smaller range, be easy to swallow；Wax-wrapped pill answers waxdip fully, uniformly when making, it is ensured that internal layer
Medicine does not exosmose；Jelly liquid should be acidified colloid composition when dosing dense lemon juice, citric acid in higher temperature, maintain necessarily
Dilution factor；Jelly liquid should be completed when being mixed with Chinese medicine wax-wrapped pill in lower temperature, prevent wax-wrapped pill from dissolving, and can do suitable to beeswax if necessary
When ungrease treatment, to improve fusing point.
The above-described embodiments are merely illustrative of preferred embodiments of the present invention, not to the structure of the present invention
Think and scope is defined, under the premise of design concept of the present invention is not departed from, ordinary skill technical staff is to this hair in this area
The all variations and modifications that bright technical scheme is made, all should fall into protection scope of the present invention, claimed skill of the invention
Art content has all been recorded in detail in the claims.
Claims (5)
1. one kind can wide variety of Chinese herbal medicine jelly preparation method, it is characterized in that comprising the following steps：
Step 1）Make wax-wrapped pill：
Chinese medicine pilling machine for wax pills is used, Chinese medicine is played into powder, dusting cover, 2.5-3.0mm of diameter water pill, ointment ball or concentration is made
Ball, then by drying, waxdip, wax-wrapped pill is made, it is standby；
Step 2）Make jelly liquid：
By gelatin, agar, water according to 1:1:8 mixing, soak 20-30 minutes, make its abundant water swelling；Then, refiner is used
It is sufficiently mixed, homogenate is made；Then, stirring at low speed and be heated to boiling, keep slight boiling condition, be continuously added distilled water, maintain
Overall solution volume, until colloid dissolving is complete, adds 0.4% -0.6% stevioside, stirs immediately, natural cooling；
Step 3）Prepare Chinese herbal medicine jelly：
When obtained jelly liquid naturally cools to 70 DEG C -80 DEG C in step 2, concentrated lemon juice, citric acid are sequentially added, is filled
Divide stirring mixing, add Chinese medicine wax-wrapped pill made from the step 1 during to 50 DEG C -65 DEG C, slowly stir evenly, Chinese herbal medicine jelly is made, point
Dress, radiosterilization, less than 20 DEG C preservations.
2. one kind according to claim 1 can wide variety of Chinese herbal medicine jelly preparation method, it is characterised in that the step 1
It is middle that Chinese medicine is broken into 500-1000 mesh powders.
3. one kind according to claim 1 can wide variety of Chinese herbal medicine jelly preparation method, it is characterised in that the step 1
Middle waxdip answers waxdip fully, uniformly when making, it is ensured that internal layer medicine does not exosmose.
4. one kind according to claim 1 can wide variety of Chinese herbal medicine jelly preparation method, it is characterised in that the step 3
Middle jelly liquid should be acidified colloid composition when dosing dense lemon juice, citric acid, maintain certain dilution factor.
5. one kind according to claim 1 can wide variety of Chinese herbal medicine jelly preparation method, it is characterised in that the step 3
Middle jelly liquid should prevent wax-wrapped pill from dissolving when being mixed with Chinese medicine wax-wrapped pill, can do ungrease treatment to beeswax if necessary, to improve fusing point.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401502A (en) * | 1992-01-17 | 1995-03-28 | Alfatec Pharma Gmbh | Pellets containing plant extracts, process of making same and their pharmaceutical peroral or cosmetic use |
| CN104522447A (en) * | 2014-12-18 | 2015-04-22 | 南方医科大学 | Jelly with effects of improving appetite and promoting digestion suitable for being taken by children |
| CN104940301A (en) * | 2015-05-31 | 2015-09-30 | 黑龙江佰彤儿童药物研究有限公司 | Pudilan children's antiviral oral pellet gel and preparation method thereof |
| CN107961227A (en) * | 2017-12-19 | 2018-04-27 | 河南中帅医药科技股份有限公司 | A kind of preparation method and application of double releasing micropills of Chinese medicinal formulae |
-
2017
- 2017-07-12 CN CN201710564557.1A patent/CN107308103A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401502A (en) * | 1992-01-17 | 1995-03-28 | Alfatec Pharma Gmbh | Pellets containing plant extracts, process of making same and their pharmaceutical peroral or cosmetic use |
| CN104522447A (en) * | 2014-12-18 | 2015-04-22 | 南方医科大学 | Jelly with effects of improving appetite and promoting digestion suitable for being taken by children |
| CN104940301A (en) * | 2015-05-31 | 2015-09-30 | 黑龙江佰彤儿童药物研究有限公司 | Pudilan children's antiviral oral pellet gel and preparation method thereof |
| CN107961227A (en) * | 2017-12-19 | 2018-04-27 | 河南中帅医药科技股份有限公司 | A kind of preparation method and application of double releasing micropills of Chinese medicinal formulae |
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