CN107307901A - A kind of Cryoablation system - Google Patents
A kind of Cryoablation system Download PDFInfo
- Publication number
- CN107307901A CN107307901A CN201710481942.XA CN201710481942A CN107307901A CN 107307901 A CN107307901 A CN 107307901A CN 201710481942 A CN201710481942 A CN 201710481942A CN 107307901 A CN107307901 A CN 107307901A
- Authority
- CN
- China
- Prior art keywords
- cooling fluid
- sacculus
- fluid
- conduit
- cryoablation system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention provides a kind of Cryoablation system, including conduit, fluid delivery member and control unit；Wherein described conduit includes central lumen and the sacculus positioned at distal end of catheter, and the flow pass for inputting the input channel of sacculus for cooling fluid and being flowed out for cooling fluid from sacculus is provided with the central chamber；The fluid delivery member supply cooling fluid simultaneously discharges cooling fluid；Described control unit fluid delivery unit is controlled.In Cryoablation system steady operation, there is relatively stable pressure value all the time in the sacculus of distal end of catheter, the fluctuation of temperature is also smaller, what treatment was performed the operation has higher success rate, and risk is also smaller；In the case where reaching same depth of ablation, with the ablation mode more optimized.
Description
Technical field
The present invention relates to a kind of Cryoablation system, stable state control is carried out to cooling fluid in particular to a kind of
Cryoablation system.
Background technology
At present, the medical minimal invasive techniques of the insertion type of the disease such as arrhythmia cordis are much studied, such as RF ablation
The technology of art treatment has had many clinical practices.Traditional radio-frequency ablation procedure in heart privileged site by discharging radio frequency
Electric current cauterise tissue is to necrosis, to realize treatment.Patient needs to bear the pain that height temperate zone is come in art, and postoperative complication is more
The shortcomings of be also exposed one by one.
The Operative risk brought for radio-frequency ablation procedure to patient, the technology of current cryoablation PCI is also begun to
Applied in clinic.Cryoablation, as cooling fluid source, is evaporated using the liquid gas of liquid nitrogen class by the absorption of liquid nitrogen,
Tissue heat is taken away, making the temperature of target site is reduced, and the cell tissue of abnormal electro physiology is destroyed, so as to reduce heart rate mistake
Normal risk.
At present, there is demand to the Cryoablation system more optimized.
The content of the invention
It is an object of the invention to provide a kind of Cryoablation system, including conduit, fluid delivery member and control unit；
Wherein described conduit includes central lumen and the sacculus positioned at distal end of catheter, is provided with defeated for cooling fluid in the central chamber
The flow pass for entering the input channel of sacculus and being flowed out for cooling fluid from sacculus；The fluid delivery member supplies cooling fluid
And discharge cooling fluid；Described control unit fluid delivery unit is controlled.
It is preferred that, wherein described control unit is by controlling the fluid delivery member to adjust the cooling fluid of input
Flow, to cause the cooling fluid for flowing through the sacculus to enter stable state within the time of setting.
It is preferred that, the time of the setting is the parameter being stored in advance in described control unit, and can be by described
The man-machine interaction unit of control unit is adjusted.
It is preferred that, the input side of the input channel of the conduit and the fluid delivery tube of fluid delivery member are connected, conduit
Flow pass outflow side and fluid delivery member fluid recovery pipe connect；In the input side of the input channel of the conduit
Provided with input side pressure sensor and input side flow control valve；And the outflow side of the flow pass in conduit is provided with outflow side
Mass flow sensor, outflow side pressure sensor and outflow side flow control valve.
It is preferred that, described control unit calculates the outflow side theoretical pressure value of the flow pass of the conduit, and with institute
State the pressure value that measures of outflow side pressure sensor to be compared, utilize pid algorithm to inputting the cooling fluid of the conduit
Flow be adjusted so that the cooling fluid enters stable state.
It is preferred that, the theoretical pressure value of the outflow side of the flow pass of the conduit is calculated by following equation：
P=c*Q2,
C=b/ (T1* ρ 1/ (T2* ρ 2) -1),
Wherein, P is the theoretical pressure of outflow side, and Q is cooling in the pipeline between sacculus and the mass flowmenter of outflow side
The flow of fluid, T1 is the temperature of the cooling fluid in sacculus, and ρ 1 is the density of the cooling fluid in sacculus, and T2 is mass flow
The temperature of cooling fluid near meter, ρ 2 is the density of the cooling fluid near mass flowmenter, and L is sacculus and mass flowmenter
Between length of pipe, A between sacculus and mass flowmenter line cross section product, a be between sacculus and mass flowmenter
Pipeline coefficient of friction, ρ is the density of the cooling fluid in pipeline between sacculus and mass flowmenter, and c and b count to be middle
Calculate variable.
It is preferred that, the described control unit theoretical pressure and the pressure value of outflow side pressure sensor measurement, when
When the measured pressure value for flowing out side pressure sensor is more than theoretical pressure, described control unit increases outflow side by pid algorithm
The aperture of flow control valve and/or reduce the aperture of input side flow control valve to reduce the input quantity of cooling fluid；And work as
When the measured pressure value for flowing out side pressure sensor is less than theoretical pressure, described control unit reduces outflow side by pid algorithm
The aperture of flow control valve and/or increase the aperture of input side flow control valve to increase the input quantity of cooling fluid.
It is preferred that, when the cooling fluid for flowing through the sacculus reaches stable state, input the amount and stream of the cooling fluid of sacculus
The amount for going out the cooling fluid of sacculus is equal.
It is preferred that, described control unit carries out pressure by input side flow control valve and/or outflow side flow control valve
Feedback control so that cooling fluid reaches phase transformation, and balloon interior when keeping treating immediately after being sprayed into sacculus
Persistently input a certain amount of cooling fluid that can fully gasify.
It is preferred that, the cooling fluid reaches supercriticality immediately after being sprayed into sacculus.
It is preferred that, the Cryoablation system is additionally provided with multiple temperature sensors of the temperature of detection cooling fluid..
In the Cryoablation system according to a preferred embodiment of the present invention, by carrying out stable state to cooling fluid
Control, can effectively control the input quantity of cooling fluid, cooling fluid can be made effectively to gasify in the sacculus of distal end of catheter, made
The refrigeration of sacculus is optimal.Have all the time in Cryoablation system steady operation, in the sacculus of distal end of catheter relatively stable
Pressure value, the fluctuation of temperature is also smaller, and treatment operation has higher success rate, and risk is also smaller；Reaching same ablation
In the case of depth, with the ablation mode more optimized.
Brief description of the drawings
The present invention is more fully described below with reference to embodiment and accompanying drawing, in the accompanying drawings：
Fig. 1 is the structural representation of the Cryoablation system according to one embodiment of the present invention；
Shown in Fig. 2 is the schematic diagram that is connected with fluid delivery member of input side and discharge side of conduit；
Shown in Fig. 3 is the temperature profile according to one embodiment of the present invention；
Fig. 4 is the guide-tube structure schematic diagram according to one embodiment of the present invention；With
Fig. 5 is the illustraton of model that theoretical pressure under stable state is calculated according to one embodiment of the present invention.
Embodiment
Below by exemplary embodiment, and with reference to accompanying drawing, technical scheme is described in further detail,
But the present invention is not limited only to the following examples.
Shown in Fig. 1 is the structural representation of the Cryoablation system 10 according to one embodiment of the present invention.It is such as attached
Shown in Fig. 1, the system 10 may include conduit 12, fluid delivery member 13 and control unit 14.
The conduit 12 includes elongated main body tube, and the main body tube includes central lumen, in the distal end of the main body tube
Provided with inflatable element, such as sacculus.Distal end generally means away from operator close to one end of patient, and near-end is often referred to close to operator
One end.One or more passages or pipeline are provided with the central chamber of the main body tube, such as fluid supplying passage, fluid are returned
The pipelines such as passage are received, so as to provide the fluid between the main body tube proximal part and distal portions, machinery and/or be electrically connected.
The near-end of the fluid supplying passage extends to the near-end of the conduit, and such as cooling fluid with fluid delivery member 13 is stored
The fluid delivery tube connection of container.The distal end of the fluid supplying passage is extended into sacculus, and it can be around balloon tube intracavitary
Axle a part coiling or wind, and by one or more holes into sacculus spray cooling fluid.The fluid recovery is led to
The distal end in road is connected with the tube chamber of sacculus, and the Fluid recovery passages proximally by the main body tube extend to the conduit
Near-end, the cooling fluid after gasification is flowed into cold by the fluid recovery pipe for the fluid delivery member 13 being connected with Fluid recovery passages
But in fluid recovery, it can also be discharged into air.
Fig. 4 shows the example arrangement of conduit according to an embodiment of the invention, and its near-end is provided with operation handle
And various interfaces.
The fluid delivery member 13 include be used for for cooling fluid provide conveying, discharge function container and pipeline,
Such as cooling fluid storage container 36, cooling fluid recovery system.The fluid delivery member 13 also includes pump, valve, heat exchanger
Structure and control element, such as pressure sensor, mass flow sensor, temperature sensor, for being delivered to the conduit
The process that cooling fluid in the sacculus of distal end is conveyed, reclaimed and/or recycled carries out data acquisition and Flow-rate adjustment.
Before cooling fluid is delivered to the sacculus of distal end of catheter, heat exchange mechanisms can be controlled to the temperature of cooling fluid.In addition,
Fluid delivery member 13 also includes one or more check-valves or relief valve CV, if stress level or stream in a part of system
Amount exceedes level require or reservation, then turns on and leads to air or cooling fluid recovery system.Fluid delivery member 13
Compression pump the pressure of cooling fluid can be controlled.
Described control unit 14 may include one or more controllers, processor and/or software module, in one embodiment
In such as including PLC technology unit 41 and man-machine interaction (HMI) unit 42.These controllers, processor and/or soft
Part module comprising instruction or algorithm, be controlled for fluid delivery unit 13, behind will be described in detail.
According to one embodiment of the present invention, PLC technology unit 41 focuses on, detects input signal and export
Instructing the executing agency of fluid delivery member 13, there is provided the order or process being automatically brought into operation with performance objective.Pass through man-machine friendship
Mutual (HMI) unit 42, operator can provide scene instruction or modification parameter etc., and PLC technology unit 41 receives instruction
And/or parameter and the executing agency that fluid delivery member 13 is sent instructions to by calculating.
Shown in Fig. 2 is the schematic diagram that is connected with discharge side with fluid delivery member 13 of input side of conduit 12.Such as Fig. 2
Shown, the input side of conduit 12 is connected with the fluid delivery tube of the fluid delivery member 13, the discharge side and fluid of conduit 12
Recovery tube is connected.Can be provided with input side pressure sensor 31, input side flow control valve 32, input in the input side of conduit 12
Side temperature sensor etc., conduit 12 discharge side provided with discharge side mass flow sensor 33, discharge side pressure sensor 34,
Discharge side flow control valve 35, waste side temperature sensor etc..The pressure or flow of cooling fluid are conveyed single by the fluid
After the control of member 13 in the sacculus of feeding conduit 12 distal end.Cooling fluid completes the fluid recovery pipe by discharge side after states of matter conversion
Discharge conduit 12.
According to an embodiment of the invention, the signal meeting of the input side pressure sensor 31 of the input side of conduit 12
The input pressure of cooling fluid is fed back, the signal of the discharge side pressure sensor 34 of the discharge side of conduit 12 can feed back cooling fluid
Discharge pressure.According to the present invention, it is necessary to control cooling fluid so that provide a constant current continuing the sacculus to Cryoablation system
In the case of the cooling fluid (so that organizing to provide lasting amount of cooling water to affected part) of amount, cooled down in the pipeline of Cryoablation system
The pressure of fluid is maintained under preset value, or is being fluctuated near preset value in the range of very little, so that cooling fluid is in ball
It is intracapsular to reach gas-liquid state balance.That is, the conveying capacity of control cooling fluid, so that cooling fluid is in cryoablation
Stable state is reached in the sacculus of system, the stable state of this stable state for being properly termed as Cryoablation system or cooling fluid.
The discharge side theoretical pressure value in the discharge side of stable state downcomer 12 of cooling fluid can be calculated, by itself and discharge
The pressure value of the actual measurement of side pressure sensor 34 is compared, then the pid algorithm Jing Guo control unit 14 is calculated, to cold
But fluid flow is adjusted, and Cryoablation system is entered stable state.
Embodiments in accordance with the present invention, it is single by man-machine interaction (HMI) before cooling fluid enters flow control valve 32
Member 42 can set or change the time span for entering stable state to cooling fluid since cryoablation treatment.The time span
There can be the default value pre-set, and store in a control unit.In this time span, control unit is according to above-mentioned
Embodiment adjusts cooling fluid to certain flow.Illustrate to realize the stable state of cooling fluid, lead below with reference to Fig. 5
The example calculation method of the discharge side theoretical pressure value of the discharge side of pipe 12.
In Figure 5, the implication of each label is as follows：
P1 is ball intraluminal pressure；
P2 is theoretical pressure (setting pressure)；
L is the length of the pipeline between sacculus and discharge side mass flowmenter mounting portion；
35 be discharge side flow control valve；
33 be discharge side mass flowmenter；
The above-mentioned model of correspondence has P1-P2=a*L* ρ * υ2/2d (1)
Wherein, a is the coefficient of friction of pipeline, and L is the distance between pipeline, and ρ is the density of cooling fluid in the pipeline, υ
For the flow velocity of fluid, d is the diameter of the pipeline.
And Q=ρ * A* υ (Q is the flow of pipeline, and A is that pipeline section is accumulated)
A=Π d2/4
Understand d2=4A/ Π, υ=Q/ ρ A
Then have：
Wherein
In certain vacuum condition, when realizing stable state in a dynamic state for system, the situation for keeping sacculus to expand completely
Under, even if mass flowmenter 33 measures the amount of the cooling fluid of outflow in numerical value pipeline.
According to equation of gaseous state ideally, it is balloon volume to have P1*V1/T1=n1*R, V1 in sacculus, and T1 is sacculus
Interior temperature, density is ρ 1, and n1 is the amount of cooling fluid；
Consider the pipeline near valve 35 or discharge side mass flowmenter 33, it is manifold volume to have P2*V2/T2=n2*R, V2,
T2 is the temperature of cooling fluid in the pipeline, and density is ρ 2, and n2 is the amount of cooling fluid；
Wherein n1=m1/M=ρ 1*V1/M, n2=m2/M=ρ 2*V2/M
Obtain P1*V1/ (T1*n1)=P2*V2/ (T2*n2)
I.e.：P1=P2*T1* ρ 1/ (T2* ρ 2)
Substitute into P1-P2=(T1* ρ 1/ (T2* ρ 2) -1) P2=b*Q2
Wherein T2, it is known that T1, it is known that
Understand P2=c*Q2 (4)
Wherein c=b/ (T1* ρ 1/ (T2* ρ 2) -1) (5)
Different pressures, at a temperature of, by N2O physical property understands that ρ 1 is much larger than ρ 2, i.e. T1* ρ 1/ (T2* ρ 2) -1>0.
In addition, for above-mentioned ρ, ρ 1 and ρ 2, the pressure and temperature value that can be detected according to Cryoablation system is by looking into
Table mode is determined.Such as temperature in sacculus can carry out actually detected；The maximum design pressure of sacculus is 30PSI, is actually disappeared
During melting, the pressure in sacculus is maintained at 18PSI, that is, ensure that sacculus overcomes blood pressure to expand completely, leaves again enough
Safe clearance.For convenience of calculation, pressure value in above-mentioned sacculus can be directly quoted in the algorithm, calculate the reason of exhaust side
By pressure.Temperature and pressure in pipeline L be able to can also be used with independent measurement the cooling fluid that discharge side measures temperature and
Pressure.
The pressure value that the theoretical pressure that control unit is relatively calculated is measured with discharge side pressure sensor 34.Work as discharge side
When the measured value of pressure sensor 34 is more than theoretical pressure, is calculated by the PID of control unit 14, can at this time increase discharge
The aperture of effluent adjustable valve 35, and/or reduce the aperture of input side flow control valve 32, to reduce the input of cooling fluid
Amount.When the measured value for discharging side pressure sensor 34 is less than theoretical pressure, calculated by the PID of control unit 14, at this time
The aperture of discharge side flow control valve 35 can be reduced, and/or increase the aperture of input side flow control valve 32, to increase cooling
The input quantity of fluid.Through overregulating, the actual outflow of amount and discharge side of the cooling fluid actually entered to the input side of conduit 12
The amount of cooling fluid is constantly corrected.
Can be defeated to balance according to the time span since cryoablation treatment to cooling fluid into stable state of setting
Enter the regulation of both the aperture of effluent adjustable valve 32 and the aperture of discharge side flow control valve 35.For example, when the time span
When smaller, the aperture of input side flow control valve 32 will increase quickly, while correspondingly regulation discharge side flow control valve 35
Aperture, quickly to realize stable state.
According to the preferred embodiment of the present invention, in the steady state the amount of the cooling fluid in the distal balloon catheter of input pipe 12 with
The amount for flowing out cooling fluid in catheter-balloon is equal, is controlled by the pressure feedback of input side flow control valve so that cooling stream
Body can reach phase transformation immediately after being sprayed into sacculus, keep balloon interior during treatment persistently to input a certain amount of fill
Divide the cooling fluid of gasification.It is preferred that, the cooling fluid can reach overcritical immediately after being sprayed into sacculus
State, the temperature that such words sacculus can reach can be minimum.
By the control mode of above-mentioned cooling fluid, the input quantity of cooling fluid can be effectively controlled, cooling can be flowed
Body effectively gasifies in the sacculus of distal end of catheter, makes the refrigeration of sacculus optimal.And in Cryoablation system steady operation,
There is relatively stable pressure value and less temperature fluctuation all the time in the sacculus of distal end of catheter, same depth of ablation is being reached
In the case of, with the ablation mode more optimized.
Shown in Fig. 3 is the temperature profile according to one embodiment of the present invention.Pass through above-mentioned control mode and algorithm
Cooling fluid is carried out after accurately controlling, enables to the temperature change in the distal balloon catheter of unit interval conduit 12 to obtain effectively
Control.Be conducive to the cryoablation treatment suitable for different patient's pathological tissues, add what system was treated in varied situations
Flexibility.
Embodiments of the present invention are not limited to described in above-described embodiment, in feelings without departing from the spirit and scope of the present invention
Under condition, those of ordinary skill in the art can make various changes and improvement to the present invention in form and details, and these are equal
It is considered within protection scope of the present invention.
Claims (11)
1. a kind of Cryoablation system, including conduit, fluid delivery member and control unit；Wherein described conduit includes center
Chamber and the sacculus positioned at distal end of catheter, input channel and the confession that sacculus is inputted for cooling fluid are provided with the central chamber
The flow pass that cooling fluid flows out from sacculus；The fluid delivery member supply cooling fluid simultaneously discharges cooling fluid；Institute
Control unit fluid delivery unit is stated to be controlled.
2. Cryoablation system according to claim 1, wherein described control unit are single by controlling the fluid to convey
Member is with the flow for the cooling fluid for adjusting input, to cause the cooling fluid for flowing through the sacculus enters within the time of setting steady
State.
3. Cryoablation system according to claim 2, the time of the setting is to be stored in advance in described control unit
Interior parameter, and can be adjusted by the man-machine interaction unit of described control unit.
4. the Cryoablation system according to Claims 2 or 3, input side and the fluid of the input channel of the conduit are conveyed
The fluid delivery tube connection of unit, the outflow side of the flow pass of conduit and the fluid recovery pipe of fluid delivery member are connected；
The input side of the input channel of the conduit is provided with input side pressure sensor and input side flow control valve；And in conduit
The outflow side of flow pass is provided with outflow side mass flow sensor, outflow side pressure sensor and outflow side Flow-rate adjustment
Valve.
5. Cryoablation system according to claim 4, described control unit calculates the flow pass of the conduit
Outflow side theoretical pressure value, and be compared with the pressure value that measures of outflow side pressure sensor, utilize pid algorithm pair
The flow for inputting the cooling fluid of the conduit is adjusted, so that the cooling fluid enters stable state.
6. Cryoablation system according to claim 5, the theoretical pressure value of the outflow side of the flow pass of the conduit
Calculated by following equation：
P=c*Q2,
C=b/ (T1* ρ 1/ (T2* ρ 2) -1),
<mrow>
<mi>b</mi>
<mo>=</mo>
<mi>a</mi>
<mo>*</mo>
<mi>L</mi>
<mo>*</mo>
<mo>/</mo>
<mrow>
<mo>(</mo>
<mn>4</mn>
<mo>*</mo>
<mi>&rho;</mi>
<mo>*</mo>
<mi>A</mi>
<msqrt>
<mrow>
<mi>A</mi>
<mo>*</mo>
<mi>&pi;</mi>
</mrow>
</msqrt>
<mo>)</mo>
</mrow>
<mo>,</mo>
</mrow>
Wherein, P is the theoretical pressure of outflow side, and Q is cooling fluid in the pipeline between sacculus and the mass flowmenter of outflow side
Flow, T1 be sacculus in cooling fluid temperature, ρ 1 be sacculus in cooling fluid density, T2 be mass flowmenter it is attached
The temperature of near cooling fluid, ρ 2 is the density of the cooling fluid near mass flowmenter, and L is between sacculus and mass flowmenter
Length of pipe, A is the line cross section product between sacculus and mass flowmenter, and a is pipe between sacculus and mass flowmenter
The coefficient of friction on road, ρ is the density of the cooling fluid in the pipeline between sacculus and mass flowmenter, and c and b become for intermediate computations
Amount.
7. Cryoablation system according to claim 6, the described control unit theoretical pressure and outflow side pressure
The pressure value of force sensor measuring, when the measured pressure value for flowing out side pressure sensor is more than theoretical pressure, the control list
Member increases the aperture of outflow side flow control valve by pid algorithm and/or reduces the aperture of input side flow control valve to reduce
The input quantity of cooling fluid；And when the measured pressure value for flowing out side pressure sensor is less than theoretical pressure, the control list
Member reduces the aperture of outflow side flow control valve by pid algorithm and/or increases the aperture of input side flow control valve to increase
The input quantity of cooling fluid.
8. the Cryoablation system according to any one of the claims, when the cooling fluid for flowing through the sacculus reaches
During stable state, the amount for inputting the cooling fluid of sacculus is equal with the amount of the cooling fluid of outflow sacculus.
9. the Cryoablation system according to the claims, described control unit by input side flow control valve and/
Or outflow side flow control valve carries out pressure feedback control so that cooling fluid reaches immediately after being sprayed into sacculus
Phase transformation, and keep balloon interior during treatment persistently to input a certain amount of cooling fluid that can fully gasify.
10. the Cryoablation system according to the claims, the cooling fluid into sacculus after being sprayed
Supercriticality is reached immediately.
11. the Cryoablation system according to the claims, the Cryoablation system is additionally provided with detection cooling stream
Multiple temperature sensors of the temperature of body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710481942.XA CN107307901B (en) | 2017-06-22 | 2017-06-22 | Cryoablation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710481942.XA CN107307901B (en) | 2017-06-22 | 2017-06-22 | Cryoablation system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107307901A true CN107307901A (en) | 2017-11-03 |
| CN107307901B CN107307901B (en) | 2021-05-11 |
Family
ID=60183870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710481942.XA Active CN107307901B (en) | 2017-06-22 | 2017-06-22 | Cryoablation system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107307901B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109431594A (en) * | 2018-12-10 | 2019-03-08 | 康沣生物科技(上海)有限公司 | A kind of pressurization Cryoablation system certainly of PID control |
| CN110151295A (en) * | 2017-11-15 | 2019-08-23 | 林斌 | A kind of vena cave bypass blood perfusion Cryoablation system |
| CN110464444A (en) * | 2019-08-14 | 2019-11-19 | 心诺普医疗技术（北京）有限公司 | A kind of Cryoablation system of temperature-controllable |
| CN111529047A (en) * | 2020-06-23 | 2020-08-14 | 上海微创电生理医疗科技股份有限公司 | Cryoablation temperature control method, system and medium |
| US10842560B2 (en) | 2017-09-08 | 2020-11-24 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
| CN113760003A (en) * | 2021-09-07 | 2021-12-07 | 苏州海宇新辰医疗科技有限公司 | Temperature control method, device and storage medium |
| CN113842206A (en) * | 2021-11-30 | 2021-12-28 | 海杰亚（北京）医疗器械有限公司 | Alcohol recovery method, device and system for cryoablation surgical equipment |
| CN114129254A (en) * | 2021-12-10 | 2022-03-04 | 苏州海宇新辰医疗科技有限公司 | Dynamic pressure balance system in balloon of cryoablation instrument |
| CN114469311A (en) * | 2021-12-30 | 2022-05-13 | 心诺普医疗技术（北京）有限公司 | Cryoablation system and method with temperature limiting function |
| CN116172687A (en) * | 2023-01-04 | 2023-05-30 | 上海交通大学 | Negative pressure regulation and control type cryotherapy system and control method |
| WO2023109623A1 (en) * | 2021-12-14 | 2023-06-22 | 杭州堃博生物科技有限公司 | Ablation target perfusion method and apparatus for perfusion pump, perfusion pump, and storage medium |
| CN116458983A (en) * | 2023-04-07 | 2023-07-21 | 心诺普医疗技术（北京）有限公司 | Cryoablation system and method with controllable cooling rate |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043931A2 (en) * | 1999-01-25 | 2000-07-27 | Lilly Software Associates, Inc. | Distribution center management system |
| WO2005089853A1 (en) * | 2004-03-23 | 2005-09-29 | Cryocath Technologies Inc. | Method and apparatus for inflating and deflating balloon catheters |
| CN103025377A (en) * | 2010-07-28 | 2013-04-03 | 美敦力 | Endoluminal ablation cryoballoon and method |
| CN103118613A (en) * | 2010-08-26 | 2013-05-22 | 克莱米迪克斯有限责任公司 | Cryoablation balloon catheter and related method |
| CN103547229A (en) * | 2010-08-05 | 2014-01-29 | 美敦力阿迪安卢森堡有限责任公司 | Cryoablation apparatuses, systems, and methods for renal neuromodulation |
-
2017
- 2017-06-22 CN CN201710481942.XA patent/CN107307901B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043931A2 (en) * | 1999-01-25 | 2000-07-27 | Lilly Software Associates, Inc. | Distribution center management system |
| WO2005089853A1 (en) * | 2004-03-23 | 2005-09-29 | Cryocath Technologies Inc. | Method and apparatus for inflating and deflating balloon catheters |
| CN103025377A (en) * | 2010-07-28 | 2013-04-03 | 美敦力 | Endoluminal ablation cryoballoon and method |
| CN103547229A (en) * | 2010-08-05 | 2014-01-29 | 美敦力阿迪安卢森堡有限责任公司 | Cryoablation apparatuses, systems, and methods for renal neuromodulation |
| CN103118613A (en) * | 2010-08-26 | 2013-05-22 | 克莱米迪克斯有限责任公司 | Cryoablation balloon catheter and related method |
Non-Patent Citations (3)
| Title |
|---|
| 郑旭煦等: "《化工原理 下》", 1 January 2016, 华中科技大学出版社 * |
| 郑桂富: "《物理化学》", 1 July 2015, 安徽大学出版社 * |
| 郝吉明等: "《大气污染控制工程》", 1 August 2002, 高等教育出版社 * |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11925409B2 (en) | 2017-09-08 | 2024-03-12 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
| US10842560B2 (en) | 2017-09-08 | 2020-11-24 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
| CN110151295A (en) * | 2017-11-15 | 2019-08-23 | 林斌 | A kind of vena cave bypass blood perfusion Cryoablation system |
| CN109431594A (en) * | 2018-12-10 | 2019-03-08 | 康沣生物科技(上海)有限公司 | A kind of pressurization Cryoablation system certainly of PID control |
| CN109431594B (en) * | 2018-12-10 | 2023-11-24 | 康沣生物科技(上海)股份有限公司 | PID-controlled self-pressurizing cryoablation system |
| CN110464444A (en) * | 2019-08-14 | 2019-11-19 | 心诺普医疗技术（北京）有限公司 | A kind of Cryoablation system of temperature-controllable |
| WO2021027682A1 (en) | 2019-08-14 | 2021-02-18 | 心诺普医疗技术（北京）有限公司 | Temperature-controllable cryoablation system |
| JP7331145B2 (en) | 2019-08-14 | 2023-08-22 | 心諾普医療技術（北京）有限公司 | Temperature controllable cryoablation system |
| CN110464444B (en) * | 2019-08-14 | 2023-03-31 | 心诺普医疗技术（北京）有限公司 | Temperature-controllable cryoablation system |
| JP2022545318A (en) * | 2019-08-14 | 2022-10-27 | 心諾普医療技術（北京）有限公司 | Temperature controllable cryoablation system |
| CN112263321B (en) * | 2020-06-23 | 2022-04-01 | 上海微创电生理医疗科技股份有限公司 | Cryoablation temperature control method, system and medium |
| WO2021258840A1 (en) * | 2020-06-23 | 2021-12-30 | 上海微创电生理医疗科技股份有限公司 | Cryoablation temperature control method and system, and computer-readable storage medium |
| CN111529047A (en) * | 2020-06-23 | 2020-08-14 | 上海微创电生理医疗科技股份有限公司 | Cryoablation temperature control method, system and medium |
| CN112263321A (en) * | 2020-06-23 | 2021-01-26 | 上海微创电生理医疗科技股份有限公司 | Cryoablation temperature control method, system and medium |
| CN113760003A (en) * | 2021-09-07 | 2021-12-07 | 苏州海宇新辰医疗科技有限公司 | Temperature control method, device and storage medium |
| CN113760003B (en) * | 2021-09-07 | 2022-03-29 | 苏州海宇新辰医疗科技有限公司 | Temperature control method, device and storage medium |
| CN113842206A (en) * | 2021-11-30 | 2021-12-28 | 海杰亚（北京）医疗器械有限公司 | Alcohol recovery method, device and system for cryoablation surgical equipment |
| CN114129254B (en) * | 2021-12-10 | 2023-05-05 | 苏州海宇新辰医疗科技有限公司 | Dynamic pressure balancing system in balloon of cryoablation instrument |
| CN114129254A (en) * | 2021-12-10 | 2022-03-04 | 苏州海宇新辰医疗科技有限公司 | Dynamic pressure balance system in balloon of cryoablation instrument |
| WO2023109623A1 (en) * | 2021-12-14 | 2023-06-22 | 杭州堃博生物科技有限公司 | Ablation target perfusion method and apparatus for perfusion pump, perfusion pump, and storage medium |
| CN114469311A (en) * | 2021-12-30 | 2022-05-13 | 心诺普医疗技术（北京）有限公司 | Cryoablation system and method with temperature limiting function |
| CN116172687A (en) * | 2023-01-04 | 2023-05-30 | 上海交通大学 | Negative pressure regulation and control type cryotherapy system and control method |
| CN116172687B (en) * | 2023-01-04 | 2024-04-23 | 上海交通大学 | Negative pressure regulation and control type cryotherapy system and control method |
| CN116458983A (en) * | 2023-04-07 | 2023-07-21 | 心诺普医疗技术（北京）有限公司 | Cryoablation system and method with controllable cooling rate |
| CN116458983B (en) * | 2023-04-07 | 2024-02-13 | 心诺普医疗技术（北京）有限公司 | Cryoablation system and method with controllable cooling rate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107307901B (en) | 2021-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107307901A (en) | A kind of Cryoablation system | |
| CN110464444A (en) | A kind of Cryoablation system of temperature-controllable | |
| US5586973A (en) | Method and device for controlled irrigation and suctioning of a liquid clarificant during endoscopic surgery | |
| CN103025377B (en) | Endoluminal ablation cryoballoon and method | |
| CA2958031C (en) | High resolution system and method for controlling high and low insufflation flow rates | |
| US6416532B1 (en) | Brain cooling apparatus and method | |
| CN101485591B (en) | Intelligent constant-voltage variable-flow pneumoperitoneum machine | |
| CN114636102B (en) | Working medium pressure control method for cryoablation | |
| WO2014138866A1 (en) | Method and apparatus for cryoadhesion | |
| CN107951559A (en) | A kind of cryosurgery system | |
| CN203341811U (en) | Cold saline perfusion ablation catheter system | |
| CN104248469B (en) | Cold saline perfusion ablation catheter system | |
| CN208756146U (en) | A kind of cryosurgery system | |
| US20050198972A1 (en) | Pressure-temperature control for a cryoablation catheter system | |
| US20140012187A1 (en) | System for heated gas insufflation in patients | |
| CN112220552B (en) | Cryoablation catheter and cryoablation system | |
| CN214549592U (en) | Microwave ablation system with sacculus | |
| EP3197406B1 (en) | Temperature control system | |
| CN114129254A (en) | Dynamic pressure balance system in balloon of cryoablation instrument | |
| CN114569241A (en) | Microwave ablation system with balloon and using method | |
| CN117100490B (en) | Air cooling control method, system, electronic equipment and readable storage medium | |
| EP2632508B1 (en) | Device for selectively cooling physiological tissue | |
| KR20240010023A (en) | fluid management system | |
| CN112156263A (en) | Uropoiesis is flushing pipe temperature control device for surgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |