CN107296636B - Hemostatic sponge device for injection, injector and kit - Google Patents
Hemostatic sponge device for injection, injector and kit Download PDFInfo
- Publication number
- CN107296636B CN107296636B CN201710325860.6A CN201710325860A CN107296636B CN 107296636 B CN107296636 B CN 107296636B CN 201710325860 A CN201710325860 A CN 201710325860A CN 107296636 B CN107296636 B CN 107296636B
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- syringe
- hemostatic sponge
- polyvinyl alcohol
- chitosan
- hemostatic
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- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 124
- 238000002347 injection Methods 0.000 title abstract description 14
- 239000007924 injection Substances 0.000 title abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 65
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 59
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 59
- 239000002131 composite material Substances 0.000 claims abstract description 22
- 230000006378 damage Effects 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 15
- 238000005187 foaming Methods 0.000 claims abstract description 9
- 238000011161 development Methods 0.000 claims abstract description 7
- 230000023597 hemostasis Effects 0.000 claims description 24
- 239000007864 aqueous solution Substances 0.000 claims description 15
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical group CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 10
- 239000003431 cross linking reagent Substances 0.000 claims description 10
- 239000003995 emulsifying agent Substances 0.000 claims description 10
- 239000004088 foaming agent Substances 0.000 claims description 10
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000000465 moulding Methods 0.000 claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000000740 bleeding effect Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000006260 foam Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 4
- 229940015043 glyoxal Drugs 0.000 claims description 4
- 229920001592 potato starch Polymers 0.000 claims description 4
- 229920002261 Corn starch Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- -1 polypropylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 230000009518 penetrating injury Effects 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 abstract description 33
- 208000014674 injury Diseases 0.000 abstract description 19
- 206010052428 Wound Diseases 0.000 abstract description 14
- 230000035515 penetration Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 206010051373 Wound haemorrhage Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000001266 bandaging Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical group O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
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- Surgical Instruments (AREA)
Abstract
An injection hemostatic kit for sinus injury, tunnel injury, and penetration injury, comprising an injectable hemostatic sponge device and an injector; the injectable hemostatic sponge device comprises a hemostatic sponge block and a connecting wire, wherein the hemostatic sponge block is a polyvinyl alcohol-chitosan composite sponge, a cylinder is sewed with a cross-shaped X-ray development line on the surface; the syringe comprises: a syringe push rod, a syringe cock, a push rod clamping seat, a syringe barrel and a syringe cap; the hemostatic sponge for preparing the hemostatic sponge block is prepared by foaming polyvinyl alcohol and chitosan, and has a three-layer structure, wherein the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol and chitosan compounds, and the proportion of chitosan is 3-10%; when in use, the syringe cap is pulled out, then the syringe is placed into a wound, the syringe push rod is pushed, and the hemostatic sponge device is filled into the wound.
Description
Technical Field
The invention relates to the field of medical instruments, relates to an injectable hemostatic sponge device, an injector and a kit, and also relates to a hemostatic sponge and a preparation method thereof.
Background
First-aid hemostasis is an important link of first-aid of war wound bleeding, and research data show that the most main cause of war wound death is that wounded bleeding reaches 50% before being sent to a treatment mechanism; even if the wounded is sent to the treatment facility, bleeding is still the leading cause of death from combat wounds and various complications. The common hemostatic methods mainly adopt finger pressure hemostasis, dressing, bandage or triangular towel compression bandaging hemostasis, autologous compression hemostasis, tourniquet hemostasis, packing methods and the like. Most of the war wound bleeding is bleeding of hole injury, sinus injury and similar wound types caused by bullets and shrapnel, and the wounds are usually hemostatic by adopting a gauze filling mode, but the defects of long hemostatic time, inconvenient application, wound adhesion and the like exist. Therefore, the research of the convenient and self-rescue high-efficiency war wound hemostasis equipment is a focus of attention at home and abroad at present, and in addition, the research of the corresponding hemostasis material is an urgent task at present.
Disclosure of Invention
The invention aims to solve the technical problem of how to design a hemostatic device which is applied to emergency treatment of live wire sinus injury, duct injury and penetrating injury bleeding, is efficient, convenient and easy to clean, and a hemostatic material matched with the hemostatic device.
In order to solve the technical problems, the invention provides an injectable hemostatic sponge device, which comprises a plurality of hemostatic sponge blocks and connecting wires, wherein the hemostatic sponge blocks are connected with each other through the connecting wires, so that the hemostatic sponge blocks can be taken out quickly after hemostasis.
Preferably, the hemostatic sponge block is a cylinder, the diameter of the cylinder is 8-10mm, and the height of the cylinder is 5-50mm.
Preferably, the surface of the hemostatic sponge block is heat-sealed or sewn with cross-shaped X-ray development lines, and the hemostatic sponge block can be checked by X-ray observation to see whether all hemostatic sponge blocks have been taken out.
Preferably, the connection line is cotton, wire or plastic wire.
Preferably, the hemostatic sponge block is a polyvinyl alcohol-chitosan composite sponge, and has the functions of rapid liquid absorption, high expansion rate, hemostasis and wound healing promotion.
Preferably, the polyvinyl alcohol-chitosan composite sponge is a sponge prepared by foaming polyvinyl alcohol and chitosan, and has a three-layer structure, wherein the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol and chitosan composites, and the proportion of chitosan is 3-10%.
The invention also provides a syringe dedicated to filling and injecting the injectable hemostatic sponge device described above, comprising: a syringe push rod, a syringe cock, a push rod clamping seat, a syringe barrel and a syringe cap; the syringe barrel is a hollow barrel body and is used for filling the injectable hemostatic sponge device, the front end and the rear end of the syringe barrel are provided with openings, the front end opening is sleeved with the syringe cap, the rear end is provided with a finger supporting part, the rear end opening is provided with the syringe cock, the center of the syringe cock is provided with a hole, the syringe push rod penetrates through the syringe cock and is inserted into the syringe barrel, the front end of the syringe push rod is provided with the push rod clamping seat, the rear end is provided with a push handle, and the push rod clamping seat is used for pushing the filled injectable hemostatic sponge device out of the syringe barrel; the syringe cap is a cylindrical sleeve, the inner diameter is not smaller than the outer diameter of the syringe barrel, and the syringe barrel can be inserted into the syringe cap and is used for preventing the injectable hemostatic sponge device in the syringe barrel from falling off from the front end opening, so that the sanitation and safety of the injectable hemostatic sponge device are ensured.
Preferably, the front end opening of the syringe barrel is a large-aperture opening, so that the injectable hemostatic sponge device in the syringe barrel can be rapidly pushed out.
Preferably, the pushing handle of the injector pushing rod is a ten-shaped pushing handle, and the overall quality of the injector is reduced on the premise of effectively ensuring the mechanical property.
Preferably, the syringe material is a polypropylene material.
Based on the hemostatic sponge device and the injector, the invention provides an injection hemostatic kit for hemostasis of sinus injury, tunnel injury and penetration injury.
The invention further aims to provide a hemostatic sponge for manufacturing the hemostatic sponge block, which is prepared by foaming polyvinyl alcohol and chitosan, wherein the hemostatic sponge has a three-layer structure, the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol and chitosan compounds, and the proportion of chitosan is 3-10%.
Simultaneously, the preparation method of the hemostatic sponge comprises the following steps:
preparing a polyvinyl alcohol aqueous solution;
preparing a mixed aqueous solution of polyvinyl alcohol and chitosan, wherein the proportion of chitosan is 3-10%;
respectively adding a cross-linking agent, a foaming agent and an emulsifying agent into the two aqueous solutions, and uniformly stirring to prepare a pure polyvinyl alcohol prepolymer and a polyvinyl alcohol/chitosan compound prepolymer;
sequentially pouring the polyvinyl alcohol/chitosan compound prepolymer, pure polyvinyl alcohol prepolymer and polyvinyl alcohol/chitosan compound prepolymer into a mould, forming at 50-70 ℃, washing and drying to obtain the composite foam sponge;
the compressed hemostatic sponge can be obtained through hot press molding.
Preferably, the cross-linking agent is formaldehyde or glyoxal, the foaming agent is potato starch or corn starch, the emulsifying agent is pentane, and the molding temperature is 60 ℃.
According to the technical scheme, the injectable hemostatic sponge device adopts an injection mode, the injectable sponge device is pushed into sinus and hole wounds by a special injector, and after the injectable sponge device enters the wounds, the injectable sponge device rapidly expands after absorbing water in blood and compresses the wounds, so that the hemostatic purpose is achieved. All the hemostatic sponge blocks are connected through the same cotton thread, so that the hemostatic sponge blocks are very easy to take out during post-treatment, and each hemostatic sponge block is thermally sealed with an X-ray developing thread or sewn with an X-ray developing thread, so that the hemostatic sponge blocks are conveniently checked in a hospital through an X-ray machine, and the sponge is prevented from being detained in a body.
The injection hemostatic kit adopts the form of an injector, and the hemostatic sponge is pushed into a wound, so that the hemostatic process is accelerated through the characteristics of liquid absorption, expansion and compression of the sponge and the like, the operation by one hand is convenient, the taking out is convenient, and the post-treatment is convenient. The prepared hemostatic sponge adopts polyvinyl alcohol and chitosan to prepare a composite structure, and has the functions of rapid liquid absorption, high expansion rate, hemostasis and wound healing promotion.
Drawings
Fig. 1 is a schematic structural view of an injectable hemostatic sponge device according to an embodiment of the present invention.
Fig. 2 is a physical diagram of a hemostatic sponge block according to an embodiment of the present invention.
Fig. 3 is a block diagram of an injector according to an embodiment of the present invention.
Fig. 4 is a diagram showing the effect of the syringe according to the embodiment of the present invention.
Fig. 5 is a schematic structural view of an injection hemostasis kit provided in an embodiment of the invention.
Fig. 6 is a schematic view of an injection hemostasis kit according to an embodiment of the invention.
Fig. 7 is an X-ray view of a hemostatic site using an injection hemostatic kit provided by an embodiment of the invention.
Wherein, 100-injectable hemostatic sponge device, 101-hemostatic sponge block, 102-connecting wire, 103-X ray development line, 200-syringe, 201-syringe push rod, 202-syringe cock, 203-push rod cassette, 204-syringe barrel, 205-syringe cap.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings 1 to 7 and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Embodiment one:
the embodiment of the invention provides an injectable hemostatic sponge device, which comprises a plurality of hemostatic sponge blocks 101 and connecting wires 102, wherein the hemostatic sponge blocks 101 are connected with each other through the connecting wires 102, the hemostatic sponge blocks 101 are conveniently and rapidly taken out after hemostasis, the hemostatic sponge blocks 101 are cylinders, the diameter of each cylinder is 8mm, the height of each cylinder is 5mm, heat-seal cross-shaped X-ray development lines are formed on the surfaces of the hemostatic sponge blocks 101, whether all the hemostatic sponge blocks 101 are taken out or not can be checked through X-ray observation, the connecting wires 102 are plastic wires, the hemostatic sponge blocks 101 are polyvinyl alcohol-chitosan composite sponge, the hemostatic sponge has the functions of rapid liquid absorption, high expansion rate, hemostasis and wound healing promotion, the polyvinyl alcohol-chitosan composite sponge is a sponge prepared by foaming polyvinyl alcohol and chitosan, and is of a three-layer structure, the upper layer and the lower layer are polyvinyl alcohol-chitosan composite, and the proportion of chitosan is 3%.
Embodiment two:
the embodiment of the invention provides an injectable hemostatic sponge device, which comprises a plurality of hemostatic sponge blocks 101 and connecting wires 102, wherein the hemostatic sponge blocks 101 are connected with each other through the connecting wires 102, the hemostatic sponge blocks 101 are cylinders, the diameter of each cylinder is 10mm, the height of each cylinder is 50mm, cross-shaped X-ray development lines are sewn on the surface of each hemostatic sponge block 101, the connecting wires 102 are metal wires, the hemostatic sponge blocks 101 are polyvinyl alcohol-chitosan composite sponge, the polyvinyl alcohol-chitosan composite sponge is prepared by foaming polyvinyl alcohol and chitosan, the hemostatic sponge is of a three-layer structure, the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol-chitosan composites, and the proportion of chitosan is 10%.
Embodiment III:
the embodiment of the invention provides an injectable hemostatic sponge device, which comprises a plurality of hemostatic sponge blocks 101 and connecting wires 102, wherein the hemostatic sponge blocks 101 are connected with each other through the connecting wires 102, the hemostatic sponge blocks 101 are cylinders, the diameter of each cylinder is 9mm, the height of each cylinder is 25mm, cross-shaped X-ray development lines are sewn on the surface of each hemostatic sponge block 101, the connecting wires 102 are cotton wires, the hemostatic sponge blocks 101 are polyvinyl alcohol-chitosan composite sponge, the polyvinyl alcohol-chitosan composite sponge is prepared by foaming polyvinyl alcohol and chitosan, the hemostatic sponge is of a three-layer structure, the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol-chitosan composites, and the proportion of chitosan is 5%.
Embodiment four:
embodiments of the present invention provide a syringe, dedicated to filling and injecting the injectable hemostatic sponge device 100 described above, the syringe 200 comprising: syringe plunger 201, syringe stopcock 202, plunger holder 203, syringe barrel 204, syringe cap 205; the syringe barrel 204 is a hollow barrel body and is used for filling the injectable hemostatic sponge device 100, the front end and the rear end of the syringe barrel 204 are provided with openings, the front end opening is sleeved with the syringe cap 205, the rear end is provided with a finger supporting part, the rear end opening is provided with the syringe cock 202, the center of the syringe cock 202 is provided with an opening, the syringe push rod 201 penetrates through the syringe cock 202 and is inserted into the syringe barrel 204, the front end of the syringe push rod 201 is provided with the push rod clamping seat 203, the rear end is provided with a push handle, and the push rod clamping seat 203 is used for pushing the filled injectable hemostatic sponge device 100 out of the syringe barrel 204; the syringe cap 205 is a cylindrical sleeve, the inner diameter is not smaller than the outer diameter of the syringe barrel 204, the syringe barrel 204 can be inserted into the syringe cap 205, and is used for preventing the injectable hemostatic sponge device 100 in the syringe barrel 204 from falling off from the front end opening, so that the sanitation and safety of the injectable hemostatic sponge device 100 are ensured, the front end opening of the syringe barrel 204 is a large-aperture opening, the injectable hemostatic sponge device 100 in the syringe barrel 204 is conveniently and rapidly pushed out, the push handle of the syringe push rod 201 is a ten-shaped push handle, and the overall quality of the syringe 200 is reduced on the premise of effectively ensuring the mechanical property, and the syringe 200 is made of polypropylene.
Fifth embodiment:
the embodiment of the invention provides an injection hemostasis kit for hemostasis of sinus injury, duct injury and penetration injury, comprising the injectable hemostasis sponge device 100 in the third embodiment and the syringe 200 in the fourth embodiment, and being convenient to be matched with each other for use. The structural design is based on the injection-assisted filling sponge high-liquid-absorption expansion hemostasis technology, and the hemostasis sponge device 100 is filled in the syringe barrel 204 during storage; in use, the syringe cap 205 is first removed, and then the syringe 200 is placed into the wound, pushing the syringe plunger 201 to fill the hemostatic sponge device 100 into the wound.
Example six:
the embodiment of the invention provides a hemostatic sponge for manufacturing the hemostatic sponge block, which is prepared by foaming polyvinyl alcohol and chitosan, wherein the hemostatic sponge has a three-layer structure, the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol and chitosan compounds, and the proportion of chitosan is 3%.
Embodiment seven:
the embodiment of the invention provides a hemostatic sponge for manufacturing the hemostatic sponge block, which is prepared by foaming polyvinyl alcohol and chitosan, wherein the hemostatic sponge has a three-layer structure, the middle layer is polyvinyl alcohol, the upper layer and the lower layer are polyvinyl alcohol and chitosan compounds, and the proportion of chitosan is 10%.
Example eight:
the embodiment of the invention provides a preparation method of the hemostatic sponge in the sixth embodiment, which comprises the following steps: preparing a polyvinyl alcohol aqueous solution; preparing a mixed aqueous solution of polyvinyl alcohol and chitosan, wherein the proportion of chitosan is 3%; respectively adding a cross-linking agent, a foaming agent and an emulsifying agent into the two aqueous solutions, and uniformly stirring to prepare a pure polyvinyl alcohol prepolymer and a polyvinyl alcohol/chitosan compound prepolymer; sequentially pouring the polyvinyl alcohol/chitosan compound prepolymer, pure polyvinyl alcohol prepolymer and polyvinyl alcohol/chitosan compound prepolymer into a mould, forming at 50 ℃, washing and drying to obtain the composite foam sponge; the compressed hemostatic sponge can be obtained through hot press molding, wherein the cross-linking agent is formaldehyde, the foaming agent is potato starch, and the emulsifying agent is pentane.
Example nine:
the embodiment of the invention provides a preparation method of the hemostatic sponge in the sixth embodiment, which comprises the following steps: preparing a polyvinyl alcohol aqueous solution; preparing a mixed aqueous solution of polyvinyl alcohol and chitosan, wherein the proportion of chitosan is 10%; respectively adding a cross-linking agent, a foaming agent and an emulsifying agent into the two aqueous solutions, and uniformly stirring to prepare a pure polyvinyl alcohol prepolymer and a polyvinyl alcohol/chitosan compound prepolymer; sequentially pouring the polyvinyl alcohol/chitosan compound prepolymer, pure polyvinyl alcohol prepolymer and polyvinyl alcohol/chitosan compound prepolymer into a mould, forming at the forming temperature of 70 ℃, washing and drying to obtain the composite foam sponge; the compressed hemostatic sponge can be obtained through hot press molding, wherein the cross-linking agent is glyoxal, the foaming agent is corn starch, and the emulsifying agent is pentane.
Example ten:
the embodiment of the invention provides a preparation method of the hemostatic sponge in the sixth embodiment, which comprises the following steps: preparing a polyvinyl alcohol aqueous solution; preparing a mixed aqueous solution of polyvinyl alcohol and chitosan, wherein the proportion of chitosan is 5%; respectively adding a cross-linking agent, a foaming agent and an emulsifying agent into the two aqueous solutions, and uniformly stirring to prepare a pure polyvinyl alcohol prepolymer and a polyvinyl alcohol/chitosan compound prepolymer; sequentially pouring the polyvinyl alcohol/chitosan compound prepolymer, pure polyvinyl alcohol prepolymer and polyvinyl alcohol/chitosan compound prepolymer into a mould, forming at the forming temperature of 60 ℃, washing and drying to obtain the composite foam sponge; the compressed hemostatic sponge can be obtained through hot press molding, wherein the cross-linking agent is glyoxal, the foaming agent is potato starch, and the emulsifying agent is pentane.
The invention designs and prepares the hemostatic sponge of the polyvinyl alcohol-chitosan composite material with superior water absorption performance and expansion performance, and provides a device, an injector and an injection sleeve applied to the hemostatic sponge, wherein the injection sleeve can be better used for hemostasis of sinus injury, duct injury and penetration injury, and preliminary experiments show that the injection sleeve is convenient to use and rapid in hemostasis. The invention is hopeful to become a hemostatic device for emergency treatment of army battlefield, is used for hemostasis of fire wire sinus injury, tunnel injury and penetration injury, is mainly equipped for individual soldiers and even rescue groups, and can also be equipped for field operations medical department and emergency medical team.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that various modifications, substitutions and changes can be made by those skilled in the art. Such modifications, substitutions and variations are also intended to be included within the scope of the invention without departing from the spirit and scope of the appended claims and their equivalents.
Claims (11)
1. The utility model provides an injectable hemostatic sponge device, its characterized in that includes a plurality of hemostatic sponge pieces and connecting wire, hemostatic sponge pieces pass through connecting wire interconnect, be convenient for take out rapidly after stopping bleeding hemostatic sponge pieces, hemostatic sponge pieces are polyvinyl alcohol-chitosan composite sponge, polyvinyl alcohol-chitosan composite sponge is the sponge of being prepared by polyvinyl alcohol and chitosan foaming, is three layer construction, and the intermediate level is polyvinyl alcohol, and upper and lower floor are polyvinyl alcohol and chitosan complex, and the proportion of chitosan is 3-10%.
2. The injectable hemostatic sponge device according to claim 1 wherein the hemostatic sponge block is a cylinder having a diameter of 8-10mm and a height of 5-50mm.
3. An injectable hemostatic sponge device according to claim 2 wherein the hemostatic sponge piece is heat sealed or sewn with a cross-shaped X-ray development line on the surface, and the hemostatic sponge piece can be checked by X-ray observation for removal of all hemostatic sponge pieces.
4. An injectable hemostatic sponge device according to claim 3 wherein the connecting wire is cotton, wire or plastic wire.
5. A syringe dedicated to filling and injecting the injectable hemostatic sponge device according to any one of claims 1 to 4, the syringe comprising: a syringe push rod, a syringe cock, a push rod clamping seat, a syringe barrel and a syringe cap;
the syringe barrel is a hollow barrel body and is used for filling the injectable hemostatic sponge device, the front end and the rear end of the syringe barrel are provided with openings, the front end opening is sleeved with the syringe cap, the rear end is provided with a finger supporting part, the rear end opening is provided with the syringe cock, the center of the syringe cock is provided with a hole, the syringe push rod penetrates through the syringe cock and is inserted into the syringe barrel, the front end of the syringe push rod is provided with the push rod clamping seat, the rear end is provided with a push handle, and the push rod clamping seat is used for pushing the filled injectable hemostatic sponge device out of the syringe barrel;
the syringe cap is a cylindrical sleeve, the inner diameter is not smaller than the outer diameter of the syringe barrel, and the syringe barrel can be inserted into the syringe cap and is used for preventing the injectable hemostatic sponge device in the syringe barrel from falling off from the front end opening, so that the sanitation and safety of the injectable hemostatic sponge device are ensured.
6. The syringe of claim 5, wherein the front opening of the syringe barrel is a large bore opening to facilitate rapid ejection of the injectable hemostatic sponge device within the syringe barrel.
7. The syringe of claim 6, wherein the push handle of the syringe push rod is a ten-shaped push handle, and the overall quality of the syringe is reduced on the premise of effectively ensuring the mechanical property.
8. The syringe of claim 7, wherein the syringe material is a polypropylene material.
9. An injectable hemostatic kit for hemostasis of sinus injuries, tunnel injuries, penetrating injuries, comprising an injectable hemostatic sponge device according to any one of claims 1-4 and the syringe according to any one of claims 5-8.
10. A method of preparing a hemostatic sponge in a hemostatic sponge device according to any one of claims 1-4 comprising the steps of:
preparing a polyvinyl alcohol aqueous solution;
preparing a mixed aqueous solution of polyvinyl alcohol and chitosan, wherein the proportion of chitosan is 3-10%;
respectively adding a cross-linking agent, a foaming agent and an emulsifying agent into the two aqueous solutions, and uniformly stirring to prepare a pure polyvinyl alcohol prepolymer and a polyvinyl alcohol/chitosan compound prepolymer;
sequentially pouring the polyvinyl alcohol/chitosan compound prepolymer, pure polyvinyl alcohol prepolymer and polyvinyl alcohol/chitosan compound prepolymer into a mould, forming at 50-70 ℃, washing and drying to obtain the composite foam sponge;
the compressed hemostatic sponge can be obtained through hot press molding.
11. The method for preparing hemostatic sponge according to claim 10, wherein the cross-linking agent is formaldehyde or glyoxal, the foaming agent is potato starch or corn starch, the emulsifying agent is pentane, and the molding temperature is 60 ℃.
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| CN107997802B (en) * | 2018-01-11 | 2020-06-30 | 四川大学华西医院 | Accurate hemostasis device in bone clearance |
| CN111195173A (en) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | Injection type hemostatic applicator and preparation method thereof |
| CN110946633A (en) * | 2019-11-26 | 2020-04-03 | 杭州电子科技大学 | Portable quick extrusion device |
| CN115584050A (en) * | 2022-10-26 | 2023-01-10 | 上海七木医疗器械有限公司 | Gelatin sponge, preparation method thereof and embolism material prepared from gelatin sponge |
| CN116036353A (en) * | 2022-12-05 | 2023-05-02 | 上海七木医疗器械有限公司 | Absorbable embolic material and preparation method and application thereof |
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