CN107287766A - A kind of electro-spinning for polyacrylonitrile/curcumin nano fiber mat method - Google Patents
A kind of electro-spinning for polyacrylonitrile/curcumin nano fiber mat method Download PDFInfo
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- CN107287766A CN107287766A CN201710691128.0A CN201710691128A CN107287766A CN 107287766 A CN107287766 A CN 107287766A CN 201710691128 A CN201710691128 A CN 201710691128A CN 107287766 A CN107287766 A CN 107287766A
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- spinning
- polyacrylonitrile
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4282—Addition polymers
- D04H1/43—Acrylonitrile series
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/44—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds
- D01F6/54—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polymers of unsaturated nitriles
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Textile Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Nonwoven Fabrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of method of electro-spinning for polyacrylonitrile/curcumin nano fiber mat, including：（1）The preparation of polyacryl-nitrile spinning fluid：Polyacrylonitrile is added in N, N dimethyl acetamides, stirred 25 hours under certain temperature, to complete swelling；Then 8 hours are stirred at room temperature to being completely dissolved, the transparent shape of polymer solution is obtained；（2）The preparation of drug solution：Curcumin is added in N, N dimethyl acetamides, ultrasound 15 minutes, to being completely dissolved；（3）By step（2）Drug solution all add steps（1）Polymer solution, continue stir 8 12 hours, obtain the orange-yellow polymer solution containing medicine, be de-gassed within ultrasonically treated 15 minutes, obtain spinning solution；（4）Electrostatic spinning is carried out using above-mentioned spinning solution, iatric fiber film is obtained, is finally dried in vacuo, produce.The inventive method is simple to operate, and time-consuming less, raw material are cheap and easy to get, can obtain diameter and aperture in nano level membrane material, it is adaptable to large-scale production.
Description
Technical field
The invention belongs to the preparation field of electrostatic spinning nano fiber pad, more particularly to a kind of electro-spinning for polyacrylonitrile/
The method of curcumin nano fiber mat.
Background technology
Electrostatic spinning refers to the process of that polymer solution or melt are sprayed and is drawn into fiber, can be prepared into material and receive
The fiber of meter ruler cun.The polymer fiber prepared compared with conventional method, method of electrostatic spinning, which prepares polymer nanofiber, has equipment
Simply, operate easily, efficiently and the nano fibrous membrane that is prepared with method of electrostatic spinning has that size is small, specific surface area is big and porosity
The advantages of.These advantages cause nanofiber to be highly suitable as pharmaceutical carrier, and medicine can be allowed to be more easy to be absorbed by the body；In addition,
In electro-spinning process, prescription formula is carried gently, the activity of medicine can be well protected, and carrier can contain medicine well；
Medicine is more with unbodied fractions distribution in nanofiber, and this also allows for the gentle release of medicine and absorbed.
Curcumin is a kind of small molecule natural polyphenol class compound, and it is extensive that modern pharmacology research shows that curcumin has
Pharmacological activity, including inhibitory action, antibacterial and anti-inflammatory anti-oxidant, to tumour cell etc..However, curcumin poorly water-soluble, easily
The phenolic hydroxyl group carried in degraded, structure is oxidizable, and oral administration biaavailability is only 1%, and these reasons strongly limit curcumin
Clinical practice.
Textile and the relation of mankind's daily life are extremely close, have long go through as pharmaceutical carrier with textile
History, such as application carry transdermal drug delivery system prepared by medicine fabric, with attractive in appearance, comfortable, permeability it is good, not allergy, do not have an injection, no
Take medicine, treat the advantages such as convenient, reduction toxic side effect, drug safety and patient's tolerance can be improved.Many researchs are tried
Drug-loading fibre is processed into various special pathways and is administered by figure, and such as permeable membrane, vagina and auricle are local, oral, be implanted into, inject
Delivery system.The present invention has prepared curcumin and polyacrylonitrile by electrostatic spinning technique the nanometer of load curcumin
Fiber, directly load avoid oxidized risk of the curcumin in preparation process.Drug-loading fibre pad prepared by the present invention can be answered
With for new transdermal drug delivery system or dermal topical application system, all had a wide range of applications in medicine and other fields.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of method of polyacrylonitrile/curcumin nano fiber mat, should
Method is quick, easy, cheap, efficient, and batch is prepared and large-scale production, is new transdermal drug delivery system or dermal topical application
System is offered reference.
The present invention a kind of electro-spinning for polyacrylonitrile/curcumin nano fiber mat method, including：
（1）The preparation of polyacryl-nitrile spinning fluid：Polyacrylonitrile is added in DMA, stirred under certain temperature
2-5 hours, to complete swelling；Then 8 hours are stirred at room temperature to being completely dissolved, the transparent shape of polymer solution is obtained；
（2）The preparation of drug solution：Curcumin is added in DMA, ultrasound 15 minutes, to being completely dissolved；
（3）By step（2）Drug solution all add steps（1）Polymer solution, continue stir 8-12 hours, obtain orange
The polymer solution containing medicine of yellow, is de-gassed, obtains spinning solution for ultrasonically treated 15 minutes；
（4）Electrostatic spinning is carried out using above-mentioned spinning solution, iatric fiber pad is obtained, is finally dried in vacuo, produce；
Step（1）Described certain temperature, temperature is 50-80 DEG C；
Step（1）The mass concentration of polyacrylonitrile is 5-10 wt.% in obtained polyacryl-nitrile spinning fluid；
Step（2）The mass concentration of curcumin is 2-6 wt.% in obtained drug solution；
Step（3）In obtained spinning solution, the mass ratio of drug solution and polyacryl-nitrile spinning fluid is 1：2~1：3；
Step（4）Specification of syringe is 10 mL in described electrostatic spinning, and syringe needle internal diameter is 0.4 ~ 0.7 mm, and receiving screen is used
Aluminium foil connects negative pole and received, and the distance of syringe needle and receiving screen is 5~10 cm；
Step（4）It is 0.1~1.2 mL/h that flow velocity is sprayed during described electrostatic spinning；
The method of the present invention is quick, easy, cheap, efficient, and suitable batch prepares polyacrylonitrile/curcumin nano fiber mat.Have
Beneficial effect
（1）The inventive method is simple to operate, time-consuming less, can obtain diameter and aperture in nano level membrane material, it is adaptable to advise
Modelling is produced；
（2）Raw material used in the present invention are cheap and easy to get, with being used as new transdermal drug delivery system or dermal topical application system
The application potential of system.
Brief description of the drawings
Fig. 1 is digital photograph figure of the electro-spinning for polyacrylonitrile/curcumin nano fiber mat；
Fig. 2 is electromicroscopic photograph figure of the electro-spinning for polyacrylonitrile/curcumin nano fiber mat；
Fig. 3 is curcumin cumulative in vitro release profiles.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments be merely to illustrate the present invention without
For limiting the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, those skilled in the art can
To be made various changes or modifications to the present invention, these equivalent form of values equally fall within the model that the application appended claims are limited
Enclose.
Embodiment 1
Electro-spinning comprises the following steps for the preparation method of polyacrylonitrile/curcumin nano fiber mat：
（1）The preparation of polyacryl-nitrile spinning fluid：The ml of polyacrylonitrile solution 5 that mass concentration is 8% is prepared, solvent is N, N- diformazans
Yl acetamide, is stirred 3 hours at 60 DEG C, to complete swelling；Then 8 hours are stirred at room temperature to being completely dissolved, is polymerize
The transparent shape of thing solution；
（2）The preparation of drug solution：The ml of curcumin solution 2 that mass concentration is 5% is prepared, solvent is N, N- dimethylacetamides
Amine, ultrasound 15 minutes, to being completely dissolved；
（3）By step（2）Drug solution 2ml all add steps（1）Polymer solution, continue stir 10 hours, obtain
The orange-yellow polymer solution containing medicine, is de-gassed, obtains spinning solution for ultrasonically treated 15 minutes；
（4）With 10 ml syringes（Syringe needle internal diameter is 0.4 ~ 0.7 mm）Extraction step（3）Middle polyacrylonitrile/curcumin spinning solution,
It is fixed on electrostatic spinning apparatus, fixed electrostatic pressure is 15 kv, it is 8 cm to receive distance, injection flow velocity is 1.0 mL/h, is carried out
Electrospinning, obtains polyacrylonitrile/curcumin composite nano-fiber membrane；
（5）The film being collected into is put into vacuum desiccator and dries 24 more than h, it is standby.
Shone according to macroscopical digital photograph of polyacrylonitrile obtained by above step/curcumin nano fiber mat and microcosmic Electronic Speculum
Piece is shown in Fig. 1 and Fig. 2 respectively.As seen from the figure, the curcumin nano fiber mat of preparation is homogeneous, fibre diameter in nanometer range, its
With higher porosity, there is good permeability as new transdermal drug delivery system or dermal topical application system.
Embodiment 2
The curcumin Cutaneous permeation experiment of polyacrylonitrile/curcumin nano fiber mat, comprises the following steps：
Polyacrylonitrile/g of curcumin nano fiber 1.0 is weighed, in 37 DEG C, 20 ml, the PBS of pH values 7.4 is released
Put.3 ml release liquids are measured in the predetermined time, the absorbance of 426 nm curcumins are determined, while supplying withdrawal amount with PBS.With
Cumulative in vitro release rate is plotted against time, and the curcumin cumulative in vitro release characteristic in nanofiber mat is as shown in Figure 3.Medicine is fine
Dimension pad has good drug release efficiency, and 60 more than % medicine can be controlled slowly to be discharged by flooding mechanism.
Claims (7)
1. a kind of electro-spinning is for the method for polyacrylonitrile/curcumin nano fiber mat, including：
（1）The preparation of polyacryl-nitrile spinning fluid：Polyacrylonitrile is added in DMA, stirred under certain temperature
2-5 hours, to complete swelling；Then 8 hours are stirred at room temperature to being completely dissolved, the transparent shape of polymer solution is obtained；
（2）The preparation of drug solution：Curcumin is added in DMA, ultrasound 15 minutes, to being completely dissolved；
（3）By step（2）Drug solution all add steps（1）Polymer solution, continue stir 8-12 hours, obtain orange
The polymer solution containing medicine of yellow, ultrasonically treated 15 min is de-gassed, and obtains spinning solution；
（4）Electrostatic spinning is carried out using above-mentioned spinning solution, iatric fiber pad is obtained, is finally dried in vacuo, produce.
2. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（1）Described certain temperature, temperature is 50-80 DEG C.
3. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（1）The mass concentration of polyacrylonitrile is 5-10 wt.% in obtained polyacryl-nitrile spinning fluid.
4. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（2）The mass concentration of curcumin is 2-6 wt.% in obtained drug solution.
5. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（3）In obtained spinning solution, the mass ratio of drug solution and polyacryl-nitrile spinning fluid is 1：2~1：3.
6. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（4）Specification of syringe is 10 ml in described electrostatic spinning, and syringe needle internal diameter is 0.4 ~ 0.7 mm, and receiving screen is used
Aluminium foil connects negative pole and received, and the distance of syringe needle and receiving screen is 5~10 cm.
7. a kind of electro-spinning according to claim 1 is for the method for polyacrylonitrile/curcumin nano fiber mat, its feature
It is：Step（4）It is 0.1~1.2 ml/h that flow velocity is sprayed during described electrostatic spinning.
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| CN201710691128.0A CN107287766A (en) | 2017-08-14 | 2017-08-14 | A kind of electro-spinning for polyacrylonitrile/curcumin nano fiber mat method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113262275A (en) * | 2021-06-11 | 2021-08-17 | 青岛大学附属医院 | Traditional Chinese medicine component for improving and regulating intestinal tracts by curcumin and preparation method thereof |
Citations (5)
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|---|---|---|---|---|
| JP2003213555A (en) * | 2002-01-09 | 2003-07-30 | Toho Tenax Co Ltd | Polyacrylonitrile-based oxidized fiber nonwoven fabric and carbon fiber nonwoven fabric and method for producing carbon fiber nonwoven fabric |
| CN101638830A (en) * | 2009-08-25 | 2010-02-03 | 江南大学 | Method for preparing nanofibre membrane |
| CN104762684A (en) * | 2015-04-01 | 2015-07-08 | 东华大学 | Curcumin-carried pH-response color-changing antibacterial fiber and preparation method thereof |
| CN104762685A (en) * | 2015-04-01 | 2015-07-08 | 东华大学 | Multifunctional fiber with pH discoloration property, antibacterial property and drug-releasing property and preparation method thereof |
| CN105040137A (en) * | 2015-06-08 | 2015-11-11 | 浪莎针织有限公司 | Method for preparing curcumin-loaded polyacrylonitrile fiber by dope dyeing method |
-
2017
- 2017-08-14 CN CN201710691128.0A patent/CN107287766A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003213555A (en) * | 2002-01-09 | 2003-07-30 | Toho Tenax Co Ltd | Polyacrylonitrile-based oxidized fiber nonwoven fabric and carbon fiber nonwoven fabric and method for producing carbon fiber nonwoven fabric |
| CN101638830A (en) * | 2009-08-25 | 2010-02-03 | 江南大学 | Method for preparing nanofibre membrane |
| CN104762684A (en) * | 2015-04-01 | 2015-07-08 | 东华大学 | Curcumin-carried pH-response color-changing antibacterial fiber and preparation method thereof |
| CN104762685A (en) * | 2015-04-01 | 2015-07-08 | 东华大学 | Multifunctional fiber with pH discoloration property, antibacterial property and drug-releasing property and preparation method thereof |
| CN105040137A (en) * | 2015-06-08 | 2015-11-11 | 浪莎针织有限公司 | Method for preparing curcumin-loaded polyacrylonitrile fiber by dope dyeing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113262275A (en) * | 2021-06-11 | 2021-08-17 | 青岛大学附属医院 | Traditional Chinese medicine component for improving and regulating intestinal tracts by curcumin and preparation method thereof |
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Application publication date: 20171024 |