CN107281440B - A Chinese medicinal composition for treating cervical and lumbar intervertebral disc prolapse and/or rheumatic osteopathia, and its preparation method - Google Patents

Abstract

A traditional Chinese medicine for treating cervical and lumbar disc herniation and/or rheumatic bone diseases comprises the following components in parts by weight: 20-50 parts of semen strychni preparata, 5-10 parts of frankincense, 5-10 parts of myrrh, 5-10 parts of eucommia bark, 5-10 parts of rhizoma curcumae longae, 5-10 parts of radix cyathulae, 5-10 parts of liquorice, 5-10 parts of ephedra, 5-10 parts of ground beetle, 5-10 parts of rhizoma atractylodis, 5-10 parts of stiff silkworm, 2-8 parts of radix angelicae pubescentis, 2-8 parts of parasitic loranthus, 2-8 parts of ligusticum wallichii, 2-8 parts of safflower, 2-8 parts of pawpaw and 2-8 parts of teasel root. The traditional Chinese medicine disclosed by the invention has the effects of enriching blood, activating blood circulation, dredging collaterals, dispelling wind, removing dampness, dispelling cold, removing stasis, promoting granulation, dissipating stagnation, promoting qi circulation, arresting convulsion, relieving pain, eliminating bony stem and spur, tonifying kidney, strengthening tendons and bones, treating both symptoms and root causes, and is quick in effect, exact in curative effect, short in recovery period, not easy to relapse and free of toxic and side effects.

Description

A Chinese medicinal composition for treating cervical and lumbar intervertebral disc prolapse and/or rheumatic osteopathia, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating cervical and lumbar disc herniation and/or rheumatic bone diseases and a preparation method thereof.

Background

The human spine is formed by connecting a plurality of vertebrae, the vertebrae are divided into four sections of cervical vertebra, thoracic vertebra, lumbar vertebra and sacral vertebra, the four sections have larger moving ranges of the cervical vertebra and the lumbar vertebra and govern the stretching and twisting of the head and the waist of the human body, so the movement of the cervical vertebra and the lumbar vertebra has the greatest influence on the stress state of the intervertebral discs. Among the weight of intervertebral discs in the spine, the lumbar intervertebral disc is the pivot vertebra in which the waist moves, and approximately 60% -70% of the weight of a human body is borne by the lumbar vertebra, which is wider and larger than other vertebral bodies. The local muscle ligament bears long-term pressure and is easy to fatigue and relax by repeated traction activities, so that the lumbar vertebra is unstable, and intervertebral disc degeneration, bulging, protrusion, slippage, fission, deformity, lumbar hyperosteogeny, ligament calcification and the like are caused, and the lumbar vertebra disease is generally called as lumbar spondylosis. Lumbar disc herniation is the most common of lumbar diseases, and can cause soreness, numbness and distending pain of the back and the waist, limited movement of the waist and lower limbs, difficulty in sitting, sleeping and squatting, incontinence of urine and stool and local muscular atrophy in severe cases, and spinal stenosis and even paralysis in some patients.

The bearing stress of the cervical vertebra is obviously reduced relative to the lumbar vertebra, but the physiological structure is more complex, the cervical vertebra canals are smaller, the change of pressure is more sensitive, the cervical vertebra is closer to the brain center when the cervical vertebra is placed, almost all physiological activities are achieved by the fact that corresponding nerves are converged into the brain through the cervical vertebra to achieve the effects of regulation, control and feedback, and therefore symptoms caused by the cervical spondylosis are more complicated and complicated. Common cervical spondylosis compresses brachial plexus nerves, so that soreness, numbness and distending pain of neck and shoulder can be caused, neck movement is limited, the neck is in a passive position, shoulder joints cannot be lifted, and the neck is radiated to the front arm, so that numbness and weakness of limbs are caused; oppression of artery and vein vessels of cervical vertebra can cause dizziness, headache, visual disturbance and cataplexy; compression of the spinal cord can cause progressive motor neuron paralysis from top to bottom; compression of sympathetic nerves can cause a series of changes in heartbeat, respiration, pulse, blood pressure, hearing, pronunciation, gastrointestinal function, etc.

The theory of traditional Chinese medicine considers that: "pain is not through, pain is not through". The waist is house of kidney, kidney is congenital foundation, kidney stores essence and produces marrow to govern bone, the relationship between kidney and bone is very close, pain in waist and lower extremities, and kidney is fundamental and impassable, which is the key. Its symptoms are classified into four categories: 1. blood stasis syndrome: pain in the waist and legs, stabbing pain in the fixed position, light day and heavy night, stiff waist, limited pitching and rolling, and tenderness in the pain position. The tongue is purple and dark, or has ecchymosis, and the pulse is wiry, tense or astringent. 2. Cold-dampness syndrome: cold pain in the loins and legs, difficulty in turning to the side, unreduced lying pain, aggravated cold and rain, cold limbs, pale tongue with white or greasy coating, and deep, tense or soft-superficial pulse. 3. Syndrome of dampness-heat: pain in the waist, weakness of the legs, pain in the pain area accompanied by heat sensation, pain increase in hot or rainy days, pain decrease after exercise, aversion to heat, thirst, scanty and brownish urine. Yellow and greasy tongue coating, soft and rapid or wiry and rapid pulse. 4. Deficiency of liver and kidney: soreness of waist, weakness of legs and knees, tiredness, alleviation of lying-down symptoms, cold hands and feet, shortness of breath and no speaking desire, soreness and pain of waist and legs, dry throat and thirst, flush complexion, lassitude and hypodynamia, vexation and insomnia, dreaminess or spermatorrhea, yellow and smelly leucorrhea, little tongue coating, wiry, thready and rapid pulse. Therefore, the key point is to treat the protrusion of the intervertebral disc, strengthen the kidney and consolidate the constitution, promote blood circulation, remove obstruction in channels, regulate cellular immunity and humoral immunity and relieve autoimmune reaction inflammation. Promoting blood circulation, removing blood stasis, dredging channels and collaterals, warming channels, dispelling cold, regulating qi-flowing, relieving pain, gradually recovering local tissue function, establishing new mechanical balance of spine, promoting blood circulation, dredging collaterals, consolidating constitution, and relieving pain.

Along with the development of society and economy, the prevalence rate of cervical spondylosis, lumbar spondylosis and rheumatoid bone diseases is doubled year by year along with the increase of human body age, and the diseases are gradually younger in age in recent years and are easy to recur, so that the cervical spondylosis, lumbar spondylosis and rheumatoid bone diseases are common diseases and frequently encountered diseases of orthopedics. The western medicine treatment mainly comprises chemically synthesized analgesic drugs, dehydration detumescence drugs, hormone drugs and immunosuppressant drugs, the drugs mainly control symptoms, basically treat symptoms without root causes, relapse and aggravation are realized quickly after the drugs are stopped, the drugs have large toxic and side effects, the clinical operation treatment sometimes needs to reach certain clinical indications or stages, the cost is huge, the risk is huge, repeated or multiple operations are possible, and irreversible lifelong injury is possibly caused once the operation fails. Generally, the traditional acupuncture, massage and traction treatment only plays a role of auxiliary drug treatment, and the condition of the patient may be aggravated if the patient loses his hand. Relatively speaking, the traditional Chinese medicine treatment has the effects of simplicity, practicability, treatment of both symptoms and root causes, small risk, low cost, difficult recurrence and easy popularization in basic medical institutions and remote areas.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine for treating cervical and lumbar disc herniation and/or rheumatic bone diseases and a preparation method thereof.

In order to solve the technical problems, the technical scheme provided by the invention is as follows:

a traditional Chinese medicine for treating cervical and lumbar disc herniation and/or rheumatic bone disease comprises the following components in parts by weight:

20-50 parts of semen strychni preparata, 5-10 parts of frankincense, 5-10 parts of myrrh, 5-10 parts of eucommia bark, 5-10 parts of rhizoma curcumae longae, 5-10 parts of radix cyathulae, 5-10 parts of liquorice, 5-10 parts of ephedra, 5-10 parts of ground beetle, 5-10 parts of rhizoma atractylodis, 5-10 parts of stiff silkworm, 2-8 parts of radix angelicae pubescentis, 2-8 parts of parasitic loranthus, 2-8 parts of ligusticum wallichii, 2-8 parts of safflower, 2-8 parts of pawpaw and 2-8 parts of teasel root.

The traditional Chinese medicine preferably further comprises additional raw material medicines, wherein the additional raw material medicines are selected from one or more of earthworm, centipede and clematis chinensis. The preferable additional raw materials can be fried by slow fire, and the earthworm is added, so that the medicine is suitable for patients with rheumatism and patients with severe arthrocele and hydrarthrosis; the clematis root is added, so that the traditional Chinese medicine is suitable for patients with serious hyperosteogeny and can eliminate bony peduncle and bony spur; the addition of Scolopendra is suitable for patients with limb immobility, intractable headache due to cervical spondylosis, and arthralgia due to wind-dampness.

Preferably, the earthworm is 2-8 parts by weight, the centipede is 2-8 parts by weight, and the clematis root is 2-8 parts by weight.

As a general inventive concept, the present invention also provides a preparation method of the above traditional Chinese medicine, comprising the following steps:

(1) parching Olibanum and Myrrha with vinegar; parching radix Cyathulae, Eucommiae cortex, and rhizoma Wenyujin Concisa with salt; parching semen Strychni preparata and radix Glycyrrhizae with sand; parching Bombyx Batryticatus and rhizoma Atractylodis with bran; parching herba Ephedrae and Eupolyphaga Seu Steleophaga with slow fire;

(2) pulverizing the parched raw materials with 80-120 mesh sieve respectively;

(3) mixing radix Angelicae Pubescentis, herba Taxilli, rhizoma Ligustici Chuanxiong, Carthami flos, fructus Chaenomelis, and radix Dipsaci, adding clear water 4-6 times of the total weight, boiling, heating for 40-60 min, decocting for two times, filtering to remove residue, heating and concentrating the medicinal liquid to 3-5 g/ml crude drug to obtain fluid extract;

(4) mixing the fluid extract with the medicinal powder obtained in step (2) to obtain soft extract, heating, sterilizing, oven drying, and making into Chinese medicinal preparations of different dosage forms.

In the above preparation method, preferably, the vinegar frying process in the step (1) is as follows: removing impurities from Olibanum and Myrrha, crushing, parching with slow fire in a pan until the surface is melted and foamed or the swelling is raised, spraying rice vinegar, parching to obtain bright and transparent outer layer, and cooling; wherein, 6 parts by mass of rice vinegar is sprayed on 100 parts by mass of frankincense or myrrh.

The invention adopts vinegar to fry frankincense and myrrh, wherein alkaloid and acetic acid are combined into acetate which is easy to dissolve out when being decocted, thereby improving clinical curative effect. The frankincense and the myrrh are resin medicines, the peculiar smell of volatile oil exists in the frying process, and the fishy smell of the medicines can be removed and the toxicity of the medicines can be reduced by frying with vinegar. Vinegar-flavored acid is preferred by liver, so it can be introduced into liver; the vinegar is warm in nature and has the effects of killing pathogenic toxin and astringing, and the frankincense and the myrrh can reduce the toxicity and relieve the property of the medicine after being stir-fried with the vinegar, so that the strong stimulation of the medicine to the digestive tract can be obviously reduced, and the side effects of nausea, vomiting and the like can be relieved.

In the above preparation method, preferably, the salt frying process in the step (2) is as follows: adding the raw materials into saline water, stirring, parching with slow fire to dry after the saline water is absorbed, taking out the parched raw materials, and cooling; wherein 2 parts by mass of common salt is used for every 100 parts by mass of the raw materials. Salt is salty and cold in kidney, mainly subsides, and can enhance the effect of the medicine on treating the disease by entering the kidney, the effect of tonifying the liver and the kidney can be enhanced after the general medicine for tonifying the liver and the kidney is fried by the salt, the curative effect can be enhanced after part of the medicine is fried by the salt, the pain relieving effect is achieved, and the hard lump softening and dissipating effect is achieved; salty cold belongs to yin, can enhance the effects of clearing heat and nourishing yin of the medicines, and can alleviate dryness of other medicines; the salt has high permeability, and can wash away mucilage of plant medicine and facilitate pulverization.

In the above preparation method, preferably, in the step (1), the stir-frying process of the processed nux vomica includes: placing sand in a hot pot, heating to 250 deg.C with strong fire, adding semen Strychni preparata, parching until brown, surface swelling, interior reddish brown, and bubbling, taking out, sieving to remove sand, and cooling; the nux vomica contains various alkaloids, including strychnine and brucine (strychnine), has a poison, the content is generally about 1.5-2.1%, the highest content can reach 5% individually, the strychnine needs to be used as a medicine after being processed, and the strychnine is dissolved and decomposed at the high temperature of 268 ℃ plus 290 ℃, but the strychnine can be destroyed by adopting a sand-ironing method, but the destruction degrees are different due to different temperatures, and the destruction to the strychnine is too large due to overhigh temperature, so that the treatment effect cannot be realized, the temperature of the sand-ironing method is creatively controlled between 240 ℃ plus 250 ℃, so that the oil is saved, the crushing is easy, the pharmacy and the taking are convenient, and the contents of the strychnine and the strychnine are not destroyed; and it can also play the role of detoxification and synergy when being combined with ephedra, liquorice and centipede.

In the above preparation method, preferably, the licorice root is fried as follows: placing the sand in a hot pot, heating to 85-95 deg.C with slow fire, adding Glycyrrhrizae radix, parching until it is yellow or deep yellow, sieving to remove sand, and cooling.

The stir-frying process of the ephedra comprises the following steps: drying herba Ephedrae, removing impurities, sieving to remove ash, placing in a frying pan, heating with slow fire to 85-95 deg.C, continuously parching until herba Ephedrae is not sticky, and cooling;

the frying process of the ground beetles comprises the following steps: taking Eupolyphaga Seu Steleophaga raw material, removing impurities, sieving to remove ash, placing in a frying pan, heating with slow fire to 85-95 deg.C, continuously parching until it is slightly burnt, taking out, and cooling.

Preferably, in the preparation method described above, in the step (3), the specific preparation process of the fluid extract is as follows: respectively purchasing decoction pieces of radix angelicae pubescentis, parasitic loranthus, ligusticum wallichii, safflower, pawpaw and teasel root, mixing the decoction pieces in proportion, adding clear water 4-6 times of the total weight, continuously heating for 40-60 minutes after boiling, filtering out liquid medicine, storing the liquid medicine in a tank for later use, adding clear water 4-6 times of the total weight into medicine dregs, continuously boiling for two times, filtering out the medicine dregs, mixing the liquid medicines extracted in the two times, heating and concentrating the liquid medicines to a fluid extract containing 4 g of the crude medicine per milliliter;

because the prescription contains a plurality of traditional Chinese medicines, the compatibility of the traditional Chinese medicines has different monarch, minister, assistant and guide, the quality and the specific gravity of the medicinal materials are different, if the traditional Chinese medicines are all processed, crushed and mixed, the mixed traditional Chinese medicines have different specific gravity, layering is easy to form in the mixing process and are not easy to be uniform, part of minister medicines and conductant medicines which are suitable for compatibility are selected in the prescription, and the traditional Chinese medicines (such as safflower, parasitic loranthus and the like) which have lighter specific gravity and are not suitable for stir-frying are prepared into extract, so that the specific gravity of each medicinal material is balanced, the medicines are uniformly mixed, the dosage is accurate; the method is simple and convenient to operate, safe and cheap, wide in dissolving range, capable of filtering most impurities and retaining active ingredients required by a formula, and the traditional Chinese medicine volatile oil components (such as radix angelicae pubescentis and ligusticum wallichii) in the fluid extract and the traditional Chinese medicine pectin tannin mucilaginous components (such as pawpaw) have certain viscosity, and can replace part of pharmaceutical excipients when being mixed with the traditional Chinese medicine powder.

In the preparation method, preferably, in the step (4), the specific operation process of sterilization is as follows: mixing the pulverized raw materials with the prepared fluid extract to obtain paste, placing in a sterilization tray, and spreading uniformly to obtain a mixture with a thickness of 1cm or less; then the sterilization tray is sent into a dry heat sterilization cabinet for sterilization。

The temperature for drying and sterilizing is 80-250 ℃, and the time for drying and sterilizing is 0.75-4 h. Generally, the dry heat sterilization temperature is 80 ℃, the dry heat sterilization is required to be carried out for 4 hours, the dry heat sterilization temperature is 160-; the dry heat sterilization temperature is 170-180 ℃, and the sterilization is required to be more than 60 minutes; the dry heat sterilization temperature is above 250 deg.C, and sterilization is required for about 45 minutes.

In the preparation method, preferably, the dosage form is one or more selected from water pills, honey pills and capsules; further, preferably, the dosage form is a capsule. The frankincense and the myrrh contain a large amount of volatile oil components, the smell is unpleasant, the nux vomica contains the strychnine and the brucine, the prepared nux vomica also has strong bitter taste, and the nausea or vomiting can be caused if the nux vomica is prepared into pills or decoction for oral administration, so the capsules are more reasonable than the pills.

The traditional Chinese medicine for treating the cervical and lumbar intervertebral disc protrusion and the rheumatoid bone disease is an oral medicine prepared by combining seventeen traditional Chinese medicines of main raw materials of frankincense, myrrh, eucommia bark, rhizoma wenyujin concinnatae, radix cyathulae, nux vomica, liquorice, ephedra, ground beeltle, rhizoma atractylodis, stiff silkworm, radix angelicae pubescentis, Chinese taxillus twig, ligusticum wallichii, safflower, pawpaw and dipsacus asperoides and optimized additional raw materials of earthworm, centipede, radix clematidis and the like; the strychnine in the semen strychni preparata can selectively excite the spinal cord and improve the powerless state of skeletal muscles, thereby causing the consistent contraction of lumbar and back muscle groups, further adjusting unbalanced vertebral bodies, achieving the effects of self traction, enlarging intervertebral space and being beneficial to nucleus pulposus accommodation, and being a monarch drug. Olibanum, Myrrha, radix Cyathulae, and radix Dipsaci, and has effects of promoting blood circulation, activating qi-flowing, dredging collaterals, relieving swelling, relieving pain, nourishing liver and kidney, and strengthening tendons and bones; eucommia bark can relieve pain, regulate blood pressure, excite nerves, resist fatigue and prevent musculoskeletal aging; rhizoma Wenyujin Concisa has effects of resisting oxidation, regulating immunity, and strengthening liver and kidney; the ground beetle breaks blood and removes stasis, and reunion of fractured tendons and bones; rhizoma Atractylodis removes dampness, invigorates spleen, dispels wind and dispels cold; bombyx Batryticatus has effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, and relieving pain; earthworm clears heat and relieves spasm, clears the channels and activates the collaterals; radix Angelicae Pubescentis has effects of lowering blood pressure, tranquilizing, relieving spasm, dispelling pathogenic wind, removing dampness, relieving arthralgia, and relieving pain, and can be used for treating soreness of waist and knees and difficulty in extending and bending of joint; herba Taxilli has effects of dispelling pathogenic wind, removing dampness, nourishing liver and kidney, and strengthening tendons and bones; clematis root is used for dispelling wind-damp and eliminating bony stem and bony spur; the pawpaw is used for clearing heat, dispelling wind, reducing swelling, eliminating stagnation and resisting gastrocnemius spasm, and is a ministerial drug and an adjuvant drug. The safflower and the szechuan lovage rhizome have the effects of enriching blood, promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain; the ephedra stem surface dispels wind evil and dispels cold toxin; scolopendra, herba Ephedrae, and Glycyrrhrizae radix can regulate the severity of each raw material medicine (especially semen Strychni preparata), have effects of reducing toxicity and enhancing efficacy, and are used as guiding drugs.

The Chinese medicinal composition combines the raw materials together, has strict formula, has the effects of enriching blood, promoting blood circulation, removing obstruction in channels, expelling wind, removing dampness, dispelling cold, removing blood stasis, promoting granulation, dissipating stagnation, promoting qi circulation, arresting convulsion, relieving pain, eliminating bony peduncle and bony spur, tonifying liver and kidney, strengthening tendons and bones, treats both principal and secondary aspect of diseases, and has the advantages of quick response, exact curative effect, short recovery period, difficult relapse and no toxic or side effect.

Compared with the prior art, the invention has the advantages that:

(1) the traditional Chinese medicine for treating cervical and lumbar disc herniation and/or rheumatic bone disease has the effects of enriching blood, promoting blood circulation, dredging collaterals, dispelling wind, removing dampness, dispelling cold, removing blood stasis, promoting granulation, resolving hard mass, promoting qi circulation, arresting convulsion, relieving pain, eliminating bony stem and bony spur, tonifying kidney, strengthening tendons and bones, treating both symptoms and root causes, and has the advantages of quick response, definite curative effect, short recovery period, difficult recurrence and no toxic or side effect, and can be used for treating symptoms and diseases such as neck, shoulder, waist and back pain, leg pain, numbness and weakness of limbs, headache and dizziness, joint movement disorder, scapulohumeral periarthritis, lumbar muscle strain, osteoarthritis, hyperosteogeny, joint effusion and the like caused by cervical and lumbar disc herniation.

(2) Compared with the traditional water boiling method, the method for preparing the nux vomica by frying the nux vomica by using the sand scalding method saves oil, is easy to crush, is convenient to prepare medicines and take, and does not destroy the contents of the strychnine and the brucine.

(3) The raw materials are fried by different methods in the preparation method process, so that the purity of the medicine can be improved, the quality is ensured, the toxicity or side effect of the medicine is reduced or eliminated, the performance of the medicine is changed or alleviated, the curative effect of the medicine is enhanced, the position and the trend of the action of the medicine are changed or enhanced, the odor and the taste are corrected, and the medicine is convenient to take.

(4) Because the traditional Chinese medicine contains a plurality of traditional Chinese medicinal materials, the compatibility of the traditional Chinese medicinal materials is different in monarch, minister, assistant and guide, the quality and the specific gravity of the medicinal materials are different, if all the traditional Chinese medicines are processed, crushed and mixed, the mixed traditional Chinese medicines are different in specific gravity, layering is easy to form in the mixing process and not easy to be uniform, part of minister medicines and conductant medicines which are suitable for compatibility are selected in the formula, and the traditional Chinese medicinal materials (such as safflower, parasitic loranthus and the like) which are lighter in specific gravity and not suitable for stir-frying are prepared into extract, so that the specific gravity of each medicinal material is balanced, the medicines are uniformly mixed, the; the method is simple and convenient to operate, safe and cheap, wide in dissolving range, capable of filtering most impurities and retaining active ingredients required by a formula, and the traditional Chinese medicine volatile oil components (such as radix angelicae pubescentis and ligusticum wallichii) in the fluid extract and the traditional Chinese medicine pectin tannin mucilaginous components (such as pawpaw) have certain viscosity, and can replace part of pharmaceutical excipients when being mixed with the traditional Chinese medicine powder.

(5) The invention follows the principle of traditional Chinese medicine compatibility monarch, minister, assistant and guide, does not have traditional Chinese medicines which are mutually incompatible, combines a plurality of medicines, utilizes the mutual synergy or resistance effect of the medicines, reduces or eliminates the toxicity or side effect of the medicines on the basis of improving the curative effect, reduces the adverse reaction, has safe clinical application, and does not stimulate the stomach and intestine after oral administration; the prepared preparation is also convenient to carry and take, ensures the purity of the medicine, is beneficial to storage, has obvious curative effect, more effective components are absorbed, the medicine property is well exerted, treats both principal and secondary aspects of diseases, can achieve long-term clinical cure, and has the total effective rate of more than 95 percent.

Detailed Description

In order to facilitate an understanding of the present invention, the present invention will be described more fully and in detail with reference to the preferred embodiments, but the scope of the present invention is not limited to the specific embodiments described below.

Unless otherwise defined, all terms of art used hereinafter have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention.

Unless otherwise specified, the various raw materials and decoction pieces used in the present invention are commercially available products or products that can be prepared by known methods.

Example 1:

the traditional Chinese medicine for treating the cervical and lumbar disc herniation and/or the rheumatoid bone disease comprises the following components in parts by weight: 130g of prepared nux vomica, 20g of frankincense, 20g of myrrh, 20g of eucommia bark, 20g of rhizoma wenyujin concisum, 20g of medicinal cyathula root, 20g of liquorice, 20g of ephedra, 20g of ground beetle, 20g of rhizoma atractylodis, 20g of stiff silkworm, 8g of radix angelicae pubescentis, 8g of parasitic loranthus, 8g of ligusticum wallichii, 8g of safflower, 8g of pawpaw, 8g of dipsacus asperoides, 8g of earthworm, 8g of centipede and 8 g.

The preparation method of the traditional Chinese medicine for treating the cervical and lumbar disc herniation and/or the rheumatoid bone disease comprises the following steps:

(1) removing impurities from Olibanum and Myrrha, pulverizing into pieces, placing in a pan, respectively parching with slow fire until the surface reaches melting point, spraying rice vinegar (6 Kg per 100Kg of raw materials), parching, and cooling;

(2) removing impurities from radix Cyathulae, collecting radix Cyathulae segments, adding saline water, stirring (2 Kg of salt per 100Kg of raw materials), moistening, placing into a frying pan, parching with slow fire, taking out, and cooling; parching Eucommiae cortex and rhizoma Wenyujin Concisa with salt, and cooling;

removing impurities from semen Strychni, placing sand in a hot pot, heating to 240 deg.C with strong fire, adding semen Strychni with consistent size, parching continuously until it is brown, removing hair, swelling two sides, soaking the interior, grasping and breaking easily, taking out, sieving to remove sand, and cooling; parching Glycyrrhrizae radix with sand, cooling (wherein the parching process comprises placing sand in a hot pan, heating with slow fire to 90 deg.C, adding Glycyrrhrizae radix, continuously parching until it is yellow or deep yellow, sieving to remove sand, and cooling); parching herba Ephedrae and Eupolyphaga Seu Steleophaga with slow fire (the parching process of herba Ephedrae comprises taking herba Ephedrae and drying raw materials, removing impurities, sieving to remove ash, placing in a parching pot, heating with slow fire to 85-95 deg.C, parching continuously, taking out when herba Ephedrae is not sticky, cooling, and parching with slow fire to 85-95 deg.C, taking out when herba Ephedrae is slightly burnt, cooling; the stiff silkworm and the rhizoma atractylodis are fried by wheat bran, and the process is as follows: heating, parching with wheat bran, adding Bombyx Batryticatus or rhizoma Atractylodis with impurities removed when smoking, turning over to dark yellow, taking out, and cooling;

(3) pulverizing the above parched materials with 80-120 mesh sieve respectively;

(4) respectively purchasing decoction pieces of radix angelicae pubescentis, parasitic loranthus, ligusticum wallichii, safflower, pawpaw and teasel root, mixing the decoction pieces in proportion, adding five times of clear water of the total weight of each decoction piece, continuously heating for 50 minutes after boiling, filtering out liquid medicine, storing the liquid medicine in a tank for later use, adding five times of clear water into dregs, continuously boiling for two times, filtering out dregs of a decoction, mixing the liquid medicines extracted in the two times, heating and concentrating to obtain a fluid extract containing 4 g of crude drugs per milliliter;

(5) mixing the pulverized raw materials with the prepared fluid extract uniformly to obtain paste, placing in a dry heat sterilization tray, and spreading uniformly to a thickness of not more than 1 cm; and then the sterilization tray is sent into a dry heat sterilization cabinet for drying sterilization, the drying sterilization temperature is 175 ℃, and the sterilization time is 60 min. Drying and sterilizing to obtain dry block, and sieving with 80-120 mesh sieve to obtain capsule of 0.25 g/capsule.

The following further explains the clinical experience effect of the drug formulation of the present invention:

clinical data:

the inventor carries out follow-up visit after clinical observation and treatment on 437 patients with cervical and lumbar disc herniation, hyperosteogeny and rheumatoid arthritis from 2001 to date, wherein the age is 25-65 years, and the course of the disease is 2-20 years.

The treatment method comprises the following steps:

the capsule of the embodiment is orally taken by adults once a day, 5-6 capsules are taken each time, 0.25g of the capsule is taken by adults with empty stomach boiled water or yellow wine before sleeping at night, thirty days are a treatment course, and bone and joint hair diseases are chronic diseases and generally need to be cured in 2-3 treatment courses.

As a result:

284 cases of clinical cure account for 65%; 83 cases of remarkable effect account for 19 percent; 48 effective cases account for 11 percent; 22 invalid cases account for 5%; the total effective rate is 95%.

Wherein the judgment standard is as follows:

and (3) healing: clinical symptoms and physical signs disappear, and the functional activity of joint muscles returns to normal;

the effect is shown: the clinical symptoms and signs basically or mostly disappear;

the method has the following advantages: the clinical symptoms are obviously improved;

and (4) invalidation: no improvement in clinical symptoms.

The usage and dosage are as follows:

the medicine is taken on an empty stomach before falling asleep at night every day (dinner can take food normally), after taking the medicine, the patient lies in bed and rests to enable cervical, lumbar and intervertebral discs and bone joints to be in a relaxed non-pressure rest state, the medicine is taken one day for the first time, three days are taken continuously, one medicine is added every other three days, and by analogy, the medicine dose can be omitted when the maximum kilogram weight (the maximum daily dose is 1 grain/10 Kg weight) of the patient reacts or reaches the day, the normal dose is 5-6 grains/day, the medicine is preferably taken by white spirit or yellow wine, the boiled water can be used, and one month is a treatment course; can be continuously taken for 2-3 courses to consolidate the treatment, and the interval between the courses is recommended to be 5-7 days.

Because the treatment dose of some medicines is close to the toxic dose, most of the traditional Chinese medicines are natural animal and plant components, and the processing process is easy to form or residual impurities are easy to cause allergy, the medicine taking method of the invention is individualized administration, the maximum daily dose is determined according to the weight of a patient, the medicine is taken in a gradual dosage manner in the medicine taking process, and no medicine dosage is reacted. The method not only considers the tolerance and the response of patients to drugs with different individual differences, but also provides a gradual adaptation and desensitization process for the patients, thereby ensuring the curative effect and the safety.

Drug reaction:

1. after the medicine is taken, pain symptoms of a diseased part can wander, the pain degree fluctuates (is relieved or intensified, and is generally caused by nucleus pulposus disintegration and shedding), the pain and the related symptoms are generally continuously relieved for 3-10 days;

2. after the medicine is taken, if slight dizziness happens, the patient cares for the patient to be yawn, stretch or lose the waist, the muscles of the limbs on the back and the waist slightly jump, and fever occurs, which indicates that the medicine reaches the optimal degree.

No dosage can be added when any one of the two reactions occurs.

Medication contraindication:

during the administration period, smoking and wine and spicy food are prohibited, fish, mung bean, coffee, tea, duck, cock and cold water bath are prohibited, wind is avoided, and sexual intercourse is prohibited.

Contraindications: patients with serious liver and kidney dysfunction, severe hypertension, coronary heart disease, tetanus, exophthalmos, diabetic complication, asthenia, and related drug allergy history, children pregnant women and hemorrhagic diseases are forbidden, and the elderly can be prevented from falling down at night.

The efficacy of the agents of the invention is further illustrated by the following representative cases:

case 1, Yang Shi, female, 47 years old, 55Kg of body weight, Hunan Henyang, suffered from lumbar intervertebral disc protrusion, hyperosteogeny, lumbar spinal stenosis causing pain in the legs and legs, difficulty in turning over after lying in bed, and difficulty in stooping and stooping. After the medicine is taken for one treatment course, the symptoms are obviously relieved, the symptoms disappear after two treatment courses, the action is free, and the disease does not relapse after two-year follow-up visits.

In case 2, cinnabar and woman, 67.5Kg, in Longwan district of Wenzhou, Zhejiang, intermittent claudication of lumbar intervertebral disc protrusion, incapability of bending waist and sitting for a long time, standing for a long time and walking for a long time, symptoms are relieved after taking the medicine for 15 days, the disease is basically cured after one treatment course, and no relapse occurs in one follow-up visit.

Case 3, a person in a certain Liao country, male, 49 years old, and who is paved and stabilized in Hunan Yin boundary of Hunan province, suffers from rheumatoid arthritis for more than ten years, the swelling of the knee joints, ankle joints and metacarpophalangeal joints is morning stiffness, particularly the left knee joint, the left knee joint can not bend during the attack, the squatting and the walking are difficult, after taking the medicine of the invention for three courses, the swelling of the knee joints and the metacarpophalangeal joints is obviously relieved, the left knee joint can freely bend and move, and the disease does not relapse after the visit for one year.

Case 4, ren Zhi' an, female, age 52, worker, weight 55Kg, Hunan Changsha, suffering from rheumatoid arthritis, cervical spondylosis, lumbar disc herniation, hyperosteogeny. Lumbago and leg pain, swelling and pain of metacarpophalangeal joints of both hands, morning stiffness, difficulty in lifting left shoulder joints, incapability of holding both hands tightly, numbness of fingertips of the left hands, and incapability of turning the left hands back to the back.

Case 5, lingzhiju, female, aged 55 years and weighed 65Kg, in the county of Pingjiang in Hunan, patient suffered from lumbar disc herniation at age of 36 years, lumbar hyperosteogeny, lumbago with distending pain of right lower limb, inability to get up, inability to walk, difficulty in bending down and squatting, inability to support self weight at waist, and numbness of right lower limb. After the medicine is taken for 2 months, the symptoms are relieved, the disease is completely cured after three and a half months, the stooping action is free, and the disease does not relapse after being followed for 10 years.

Case 6, Huang' e lan, woman, aged 64 years, weighed 54Kg, suffered from lumbar disc herniation, hyperosteogeny and spinal stenosis by middle street man in east village, county, south of Hunan province, 50 years old; lumbago and leg pain at two sides, accompanied by radiating pain of lower limbs, numbness of foot backs, numbness of toe tips, inability to walk normally, limp in the daytime, inability to straighten waist, inability to sit for a long time, and inability to support people in getting up and squatting. The lumbago and leg pain symptom is relieved after two months of taking the medicine, the cure symptom completely disappears after half a year, and no relapse occurs until the follow-up is reached.

Case 7, a person who is maiden, a woman who is 64 years old and 41kg in weight, Dongchun City gate Dongchun in Pingjiang county of Hunan province No. 30, lumbago and skelalgia on both sides recurred for more than ten years, aggravated when tired and cold, failed to walk normally, failed to walk for a long time, sit for a long time, fail to bend down, difficulty in squatting and standing up in the flat day, and needed to be assisted when the person lies in bed and stands up. CT and MRI examination in people hospitals in Pingjiang county show prolapse of lumbar intervertebral disc, nerve root compression, lumbar vertebra degeneration and hyperosteogeny. The medicine of the invention can relieve symptoms after one and a half months, basically cure the disease after three months, has no lumbago and skelalgia, can be self-managed in life, can move freely, and has no relapse after one year of follow-up visit.

Case 8, Ling a chapter, male, 53 years old, renovation worker, weight 62.5KG, patient's neck pain and lumbago of village official lawn group of Zhengguan beach of Pingjiang county of Hunan, patient's neck pain and lumbago have recurrent attacks for four years, aggravation life can not be managed for 2 years, patient's neck pain and lumbago have recurrent attacks four years ago, accompany left upper limb and right lower limb pain, then conscious can endure, symptoms become worse gradually two years ago, waist can not support body weight, need lean on to turn, waist can not straighten, can not walk, difficulty in going upstairs and downstairs, through Shandong sunshine people hospital, Hunan Changshan lake hospital, Pingjiang county people hospital check for cervical spondylosis for many times, lumbar spondylosis, intervertebral disc protrusion with spinal canal stenosis, cervical and lumbar vertebra degeneration, after taking the pharmaceutical preparation of the present invention, symptoms gradually change day and day after two months, symptoms disappear, and no recurrence after two years.

Claims (8)

1. The traditional Chinese medicine for treating the rheumatoid bone disease is characterized by being prepared from the following components in parts by weight:

20-50 parts of semen strychni preparata, 5-10 parts of frankincense, 5-10 parts of myrrh, 5-10 parts of eucommia bark, 5-10 parts of rhizoma curcumae longae, 5-10 parts of radix cyathulae, 5-10 parts of liquorice, 5-10 parts of ephedra, 5-10 parts of ground beetle, 5-10 parts of rhizoma atractylodis, 5-10 parts of stiff silkworm, 2-8 parts of radix angelicae pubescentis, 2-8 parts of parasitic loranthus, 2-8 parts of ligusticum wallichii, 2-8 parts of safflower, 2-8 parts of pawpaw, 2-8 parts of dipsacus asperoides and additional raw material medicines; the additional raw material medicines comprise 2-8 parts of earthworm, 2-8 parts of centipede and 2-8 parts of clematis root.

2. A method for preparing the traditional Chinese medicine of claim 1, comprising the following steps:

(1) parching Olibanum and Myrrha with vinegar; parching radix Cyathulae, Eucommiae cortex, and rhizoma Wenyujin Concisa with salt; parching semen Strychni preparata and radix Glycyrrhizae with sand; parching Bombyx Batryticatus and rhizoma Atractylodis with bran; parching herba Ephedrae and Eupolyphaga Seu Steleophaga with slow fire;

(2) pulverizing the parched raw materials with 80-120 mesh sieve respectively;

(3) mixing radix angelicae pubescentis, parasitic loranthus, ligusticum wallichii, safflower, pawpaw and teasel root, adding clear water which is 4-6 times of the total weight, continuously heating for 40-60 minutes after boiling, filtering out liquid medicine, adding clear water which is 4-6 times of the total weight into medicine dregs, continuously heating for 40-60 minutes after boiling, filtering out medicine dregs, heating and concentrating the medicine liquid which is filtered out twice until each milliliter contains 3-5 g of crude drugs, and obtaining fluid extract;

(4) mixing the extract with the medicinal powder obtained in step (2) to obtain soft extract, heating, sterilizing, oven drying, and making into Chinese medicinal preparations of different dosage forms.

3. The method of claim 2, wherein the vinegar frying process in the step (1) is: removing impurities from Olibanum and Myrrha, crushing, parching with slow fire in a pan until the surface is melted and foamed or the swelling is raised, spraying rice vinegar, parching to obtain bright and transparent outer layer, and cooling; wherein, 6 parts by mass of rice vinegar is sprayed on 100 parts by mass of frankincense or myrrh.

4. The method of claim 2, wherein the salt frying process in step (1) comprises: adding the raw materials into saline water, stirring, parching with slow fire to dry after the saline water is absorbed, taking out the parched raw materials, and cooling; wherein 2 parts by mass of common salt is used for every 100 parts by mass of the raw materials.

5. The preparation method of claim 2, wherein in the step (1), the stir-frying process of the processed nux vomica is as follows: placing sand in a hot pot, heating to 250 deg.C with strong fire, adding semen Strychni preparata, parching until brown, surface swelling, interior reddish brown, and bubbling, taking out, sieving to remove sand, and cooling;

the frying process of the liquorice comprises the following steps: placing the sand in a hot pot, heating to 85-95 deg.C with slow fire, adding Glycyrrhrizae radix, parching until it is yellow or deep yellow, sieving to remove sand, and cooling.

6. The preparation method of claim 2, wherein in the step (1), the parching process of the ephedra herb is as follows: drying herba Ephedrae, removing impurities, sieving to remove ash, placing in a frying pan, heating with slow fire to 85-95 deg.C, continuously parching until herba Ephedrae is not sticky, and cooling;

the frying process of the ground beetles comprises the following steps: taking Eupolyphaga Seu Steleophaga raw material, removing impurities, sieving to remove ash, placing in a frying pan, heating with slow fire to 85-95 deg.C, continuously parching until it is slightly burnt, taking out, and cooling.

7. The preparation method according to claim 2, wherein in the step (4), the specific operation process of sterilization is as follows: mixing the pulverized raw materials with the prepared fluid extract to obtain paste, placing in a sterilization tray, and spreading uniformly to obtain a mixture with a thickness of 1cm or less; and then the sterilization tray is sent into a dry heat sterilization cabinet for drying and sterilization.

8. The method of claim 2, wherein the dosage form is selected from the group consisting of a water pill, a honey pill, and a capsule.