CN107281416A - A kind of preparation that urarthritis is treated containing long-nosed pit viper - Google Patents
A kind of preparation that urarthritis is treated containing long-nosed pit viper Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The present invention relates to a kind of preparation that urarthritis is treated containing long-nosed pit viper, category Chinese herbal medicine preparation technology field.The preparation that it is made up of the taste Chinese herbal medicine of long-nosed pit viper, coix seed, edible tulip etc. three.The present invention is to the pathogenetic research of urarthritis and principle of reatment based on motherland's medical science, with reference to scientific achievement of the modern Chinese herbal medicine theoretical research to urarthritis Chinese herbal treatment, use with long-nosed pit viper dispelling wind and removing obstruction in the meridians, be aided with coix seed excreting dampness eliminating impediment, detoxicating and resolving a mass；Edible tulip is clearing heat and detoxicating, reducing phlegm and resolving masses；Three's compatibility brings out the best in each other, complemented each other, and plays the role of dispelling wind and removing obstruction in the meridians, excreting dampness eliminating impediment, heat-clearing dissipating bind.Prescription of the present invention is rigorous, both meets theory of traditional Chinese medical science, and new knowledge of the modern medicine to urarthritis is met again, is had no toxic side effect；To urarthritis redness and swelling of joints extremely, heat pain, stiff, joint stuffiness and suppress uric acid and form evident in efficacy, while also having obvious curative effects to rheumatic fever, rheumatoid arthritis, ankylosing spondylitis, degenerative arthritis.
Description
Technical field
The present invention relates to a kind of preparation that urarthritis is treated containing long-nosed pit viper, category Chinese herbal medicine preparation technology field.
Background technology
Urarthritis belongs to motherland's medical science " bi Zheng " category, waits similar with the disease such as " severe and migratory arthralgia ".Bright Zhang Jingyue exists《Scape
Yue Quanshu tinea pedis》In think gout " be that cold sensation of the genitalia water is wet outside, modern damp evil attacks people's flesh tendon, it is interior by delicious food usually excessively, moist chamber
Lower Jiao, it is cold mutually to be tied with damp evil strongly fragrant and change heat, the red and swollen hectic fever of the diseased regions such as skin is stopped, then bone loses long ".Gong Tingxian exists《Ten thousand diseases
Because of the spring》In point out " all gouts limbs pain person, pain belong to fire, swell category it is wet ".Modern medicine thinks that gout is due to heredity or obtained
Venereal disease because cause disorders of purine metabolism and blood uric acid persistently raise caused by disease, it is long-term purine metabolic disturbance, blood
One group of disease of tissue damage caused by uric acid increases.Urarthritis First-episode be generally affected joints it is red, swollen, hot, pain, such as
Not in time, course of disease delay can cause cartilage hypertrophy, deformity, stiff, the formation of tophus for treatment, or even can cause skin diabrosis,
Form fistula.
Clinically generally prevent arthritis from recurring to alleviate acute arthritis breaking-out, correct hyperuricemia, prevent because of urine
The complication that hydrochlorate is deposited on caused by kidney, joint etc. is main purpose.When acute arthritis is broken out, lithate is mainly eliminated
The inflammation of induction, using colchicin, nonsteroidal anti-inflammatory drug, with alkalized urine, promotes uric acid to dissolve.Disease alleviation and
Gout recurrence aspect is prevented, allopurinol, benzbromarone tablets, probenecid and Febustat piece etc. has certain curative effect.Although western
Cure and treat, usual medicine for oral administration 3~7 days can quick symptom relief, but oral western medicine easily produces side effect to human body, cause liver,
The problem of functional lesions such as kidney, stomach, easily occurs adverse reaction.In addition is exactly operative treatment, primarily directed to dysarthrasis,
Tophus, the patient of fistula formation, take the method cut off in affected area, but operative treatment can not to urarthritis
Thoroughly eradicate, the method treatment patient's pain is big, and operation diseased region often delays refractory conjunction, there is certain risk, and expense
Height, easily recurrence.Due to disease condition in recent years have gradually rise and rejuvenation trend, cause during many scholars increasingly pay attention to
The research of herbtherapy gout.
The content of the invention
The purpose of the present invention is the understanding to urarthritis according to motherland's medical science, is used with long-nosed pit viper dispelling wind and removing obstruction in the meridians, auxiliary
With coix seed excreting dampness eliminating impediment, detoxicating and resolving a mass；Edible tulip is clearing heat and detoxicating, reducing phlegm and resolving masses.According to above herbal composite to gout
Property arthritis redness and swelling of joints extremely, heat pain, stiff, joint stuffiness and suppress uric acid and form significant curative effect, and nontoxic secondary make
With.
The present invention is to realize above-mentioned purpose by the following technical solutions：
A kind of preparation that urarthritis is treated containing long-nosed pit viper, it is characterised in that it is made up of the raw material of following weight percentage
Preparation：
Long-nosed pit viper 40-50% coix seed 30-35% edible tulips 20-25%；
The technical solution of the present invention, is former based on the research pathogenetic to urarthritis of motherland's medical science and treatment
Then, with reference to scientific achievement of the modern Chinese herbal medicine theoretical research to urarthritis Chinese herbal treatment, this herbal composite has
Dispelling wind and removing obstruction in the meridians, excreting dampness eliminating impediment, heat-clearing dissipating bind, resolving sputum analgesic, so as to improve microcirculation in human body obstacle, suppress uric acid and are formed, reached
The effect for the treatment of both principal and secondary aspect of disease.
The present invention also has obvious treatment to rheumatic fever, rheumatoid arthritis, ankylosing spondylitis, degenerative arthritis etc. simultaneously
Effect.
In above-mentioned raw materials component of the present invention, the pharmacology and drug effect of each component raw material are as follows：
Long-nosed pit viper：Belong to Viperidae, originate in Qichun Qi Zhoulong peaks mountain, Hubei and Hunan Provinces, the band of three hornberg one.Long-nosed pit viper sweet-salty, warm-natured, return liver warp.
Wind-dispelling, dredging collateral, only convulsion.According to《Compendium of Materia Medica》Described in：Deep can search wind, cut it is frightened jerk surely, be wandering arthritis, it is frightened jerk, favus, malignant sore will
Medicine.Modern study shows that long-nosed pit viper has calm, hypnosis and analgesic activity；Water extract can activate fibrinolytic system；Alcohol extract can strengthen huge
Phagocyte phagocytic activity, dramatically increases Carbon clearance rate.
Edible tulip：Sweet, micro-pungent is cold in nature, enter liver, stomach, the spleen channel.Clearing heat and detoxicating, carbuncle that disappears dissipating bind.According to《Bencao Shiyi》Middle note
Carry：Main carbuncle swells sore fistula, scrofula tuberculosis etc..Modern study shows that edible tulip contains the compositions such as colchicin, and acute gout is closed
Section inflammation has especially significant antiinflammatory action, and its mechanism of action is mainly destruction cellular microtubules system, disturbs fibroblast excretion
Procollagen, makes the formation of collagenous fibres be obstructed.
Coix seed：Slightly sweet flavor, it is cool in nature.Returns spleen, stomach, lung channel.Excreting dampness eliminating impediment, detoxicating and resolving a mass.According to《Book on Chinese herbal medicine is just》Described in：The heart of a lotus seed
Job's tears, slightly sweet flavor, gas is micro- cool, and property edges down and oozed, therefore the Li Shui that can dry, and is dried with it, therefore the sharp joint of energy, except tinea pedis, controls impotence weak inflexible
Contraction arthritis with fixed pain caused by dampness, consumer edema pain.
The present invention can be made into the oral formulations such as capsule, granule, pill, tablet；Its preparation method is as follows, with capsule
Exemplified by, the preparation being made by the raw material of following percentage by weights：
The edible tulip 25% of 45% coix seed of long-nosed pit viper 30%；
After the cleaned drying of said herbal medicine, weigh each raw material by above-mentioned percentage and be ground into the smalls of 100 mesh and stir,
No. 0 capsule is reloaded into product, net weight 0.4 gram/every.
Orally：1~2 time on the 1st, every time 3；It can take effect within usual 1 to 3,15 to 20 are 1 course for the treatment of, according to trouble
The state of an illness of person can suitably increase and decrease the course for the treatment of.
The beneficial effect of the present invention compared with prior art is：
This utilizes the synthesis co-action for treating gout arthritis of various medicines containing the preparation that long-nosed pit viper treats urarthritis,
Its prescription is aided with coix seed excreting dampness eliminating impediment, detoxicating and resolving a mass with long-nosed pit viper dispelling wind and removing obstruction in the meridians；Edible tulip is clearing heat and detoxicating, reducing phlegm and resolving masses.Three
Compatibility brings out the best in each other, complemented each other, and plays the role of dispelling wind and removing obstruction in the meridians, excreting dampness eliminating impediment, heat-clearing dissipating bind.This preparation have medicine energy it is grand,
It is evident in efficacy, cheap, easy to use, the advantages of have no toxic side effect；Prescription is rigorous, both meets theory of traditional Chinese medical science, meets existing again
New knowledge for medical science to urarthritis, clinical practice has repeated and blanket meaning.Simultaneously to rheumatic fever,
Rheumatoid arthritis, ankylosing spondylitis, degenerative arthritis etc. also have obvious curative effects.
In order to illustrate curative effect of the present invention to treatment urarthritis, the present invention is respectively in Songzi Cui Linshan hospitals, chaste tree
Zhou Kequan hospitals, Kepitong rheumatism research institute of Jingzhou City have carried out clinical observation in totally 310 patients, and its clinical data is such as
Under：
1st, general information：310 urarthritis patients of this group are out-patient, male 207, women 103；Morbidity
Age, 12 within 30 years old, 31 years old to 60 years old 263, more than 60 years old 35, wherein max age is 82 years old, and minimal ages are
10 years old；The course of disease 27 within 1 month, 1 to 6 month 41,6 months to 2 years 67,2 to 5 years 109,15 to 10 years 49
Example, more than 10 years 17, wherein most long 35 years, most short 2 days.Above case diagnosis standard is strict with reference to U.S.'s rheumatism association
Can gouty joint inflammation diagnostic criterias in 1977 and clinical rheumatology（Zhang Naizheng clinical rheumatology Shanghai:Shanghai science
Technology publishing house, 1999,367-371.）；Determined after laboratory blood uric acid inspection and detailed physical examination as pain
Wind arthritic.
2nd, efficacy assessment standard（Issued with reference to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》）：
It is effective：Arthralgia is disappeared, and redness is eliminated, and function of joint is recovered substantially, can participate in normal work and work, laboratory inspection
Look into normal.
Effectively：Arthralgia is alleviated, and redness abatement, laboratory examination makes moderate progress.
It is not cured：Symptom and laboratory examination are unchanged.
3rd, clinical evaluation result：310 urarthritises are treated according to above-mentioned criterion, its treatment time is most short by 2
My god, it is most long 15 days；Effective 256,82.6% is accounted for, effective 35,11.3% is accounted for, not more 19, account for 6.1%, total effective rate 93.9%.
Illustrate that the present invention treats the evident in efficacy of the preparation for treating urarthritis of urarthritis containing long-nosed pit viper（Above evaluation result
It is short term effect, follow-up of patients is that within 6 months to 12 months, late result judges again after follow-up after 2 years the time）.
Embodiment
One specific embodiment of act is produced to the present invention below.（By taking 100kg raw materials as an example）
Each raw material is weighed by aforementioned weight percentage：
Long-nosed pit viper 50kg coix seed 30kg edible tulips 20kg；
Specifically preparation process is：The smalls that above-mentioned each Chinese herbal medicine powder is broken into 100 mesh stirs, and is then being put into capsule machine thing
Material container is built-in to be filled hard shell capsules or is put into tabletted in tablet press machine.
Usage and dosage：1~2 time on the one, every time 3 or 3；Orally, 15 days are 1 course for the treatment of, can suitably be increased and decreased according to the state of an illness
The course for the treatment of.
Points for attention：A, the deficiency of Yin and blood-head person use with caution；B, pregnant woman use with caution；The empty weakling of c, category uses with caution.
Model case one：
Peng Anming, 58 years old, builder, Hubei people from Jiangling.Patient feels oneself left hand, right ankle, right foot without obvious inducement before 5 years
Mu toe joints swelling pain, limitation of activity, he does not take notice of during beginning, is thought as and oneself has walked that causes more, but this
One symptom but continue for a wheat harvesting period fully, and symptom is also more and more severe.Local commune hospital is once with rheumatoid arthritis
Treated, oral anti-inflammatory drug, brufen etc., pain postpones solution.Half a year front right finger near-end ulceration, blood uric acid is up to
718umol/L, is diagnosed as：Urarthritis.Allopurinol, metacortandracin etc. are taken, the state of an illness has taken a turn for the better, but because of stomachache not
Fit and withdraw.August in 2016 is come Songzi Cui Linshan hospitals on the 9th and sought medical advice.Have a medical check-up：Left index finger middle finger swells and ache ulceration, left foot hallux toe
Also swell and ache more very inner side.Blood uric acid 739umol/L, bitter taste, yellow and greasy fur, wiry and rolling pulse is strong, tophus tubercle.It is diagnosed as：Gout
Property arthritis.Treat the capsule for advising it to be made of said herbal medicine orally, 3 every time, 2 times a day；After 2 days, pain subtracts greatly,
Secretion at ulceration has been reduced, and pain disappears after 5 days, and blood uric acid close to normal, continues with our 2 course for the treatment of to consolidate treatment
Effect, on May 20th, 2017 pays a return visit, and does not recur.
Model case two：
Zhang Tong, man, 55 years old, company manager, people from Honghu in Hubei province.There is finger, toes swollen joint before 3 years without obvious inducement in patient
Bitterly, think and drink furthermore weariness from a tiring journey again and again, be affected by the cold and do not mind, local clinic is once treated with rheumatic fever, intravenous infusion green grass or young crops
Mycin, cephalo and oral indometacin, loxoprofen etc. are treated.1 year front right finger near-end ulceration, blood uric acid is up to 651umol/L,
It is diagnosed as：Urarthritis.Oral dexamethasone, colchicin etc., pain relief, but because stomachache discomfort is withdrawn.2017 1
The moon comes Jing Zhou Ke Quan hospitals on the 7th and sought medical advice.Have a medical check-up：Hand thumb forefinger swells and ache ulceration.Swollen and ache more very on the inside of left foot hallux toe.Blood uric acid
723umol/L, bitter taste, yellow and greasy fur, wiry and frequent pulse, tophus tubercle.It is diagnosed as：Urarthritis.Treatment advises it with above-mentioned
The capsule that herbal medicine is made is oral, and 3 every time, 2 times a day；After 1 day, pain relief, pain disappears after 3 days, is continuing with this
Secretion at 2 course of therapy of side, ulceration disappears, and blood uric acid recovers normal, and on June 3rd, 2017 pays a return visit, and asks for sick leave and does not recur.
Simply presently preferred embodiments of the present invention described above, the example above illustrates that the substantive content not to the present invention is made
Any formal limitation, technology of the person of an ordinary skill in the technical field after this specification has been read according to the present invention
Any simple modification or deformation that essence is made to above embodiment, and possibly also with the technology contents of the disclosure above
The equivalent embodiment of equivalent variations is changed or is modified to, in the range of still falling within technical solution of the present invention, without departing from
The spirit and scope of the invention.
Claims (1)
1. a kind of preparation that urarthritis is treated containing long-nosed pit viper, it is characterised in that it is by the raw material system of following weight percentage
Into preparation：
Long-nosed pit viper 40-50% coix seed 30-35% edible tulips 20-25%；
The smalls that above-mentioned each Chinese herbal medicine is ground into 100 mesh according to the above ratio stirs, and is then being put into capsule machine material appearance
Device is built-in to be filled hard shell capsules or is put into tabletted in tablet press machine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210243990.6A CN114392331A (en) | 2017-07-14 | 2017-07-14 | Preparation containing Agkistrodon for treating gouty arthritis |
| CN201710574455.8A CN107281416A (en) | 2017-07-14 | 2017-07-14 | A kind of preparation that urarthritis is treated containing long-nosed pit viper |
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| CN201710574455.8A CN107281416A (en) | 2017-07-14 | 2017-07-14 | A kind of preparation that urarthritis is treated containing long-nosed pit viper |
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| CN202210243990.6A Division CN114392331A (en) | 2017-07-14 | 2017-07-14 | Preparation containing Agkistrodon for treating gouty arthritis |
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| CN202210243990.6A Pending CN114392331A (en) | 2017-07-14 | 2017-07-14 | Preparation containing Agkistrodon for treating gouty arthritis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939179A (en) * | 2020-08-24 | 2020-11-17 | 苏州人本药业有限公司 | Application of cobra venom or extract thereof in preparation of medicine for reducing uric acid and/or resisting gouty arthritis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100446782C (en) * | 2005-10-27 | 2008-12-31 | 上海中医大源创科技有限公司 | Traditional Chinese medicine gels for treating acute gout arthritis |
| CN103405653B (en) * | 2013-08-26 | 2015-02-04 | 湖北景川药业有限公司 | External preparation for treating gouty arthritis |
-
2017
- 2017-07-14 CN CN201710574455.8A patent/CN107281416A/en active Pending
- 2017-07-14 CN CN202210243990.6A patent/CN114392331A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939179A (en) * | 2020-08-24 | 2020-11-17 | 苏州人本药业有限公司 | Application of cobra venom or extract thereof in preparation of medicine for reducing uric acid and/or resisting gouty arthritis |
| CN111939179B (en) * | 2020-08-24 | 2022-08-19 | 苏州人本药业有限公司 | Application of cobra venom or cobra venom extract in preparation of medicine for reducing uric acid and/or resisting gouty arthritis |
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| CN114392331A (en) | 2022-04-26 |
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