CN107281195A - 一种降低抗生素残留的水产养殖用药物组合物 - Google Patents
一种降低抗生素残留的水产养殖用药物组合物 Download PDFInfo
- Publication number
- CN107281195A CN107281195A CN201710497654.3A CN201710497654A CN107281195A CN 107281195 A CN107281195 A CN 107281195A CN 201710497654 A CN201710497654 A CN 201710497654A CN 107281195 A CN107281195 A CN 107281195A
- Authority
- CN
- China
- Prior art keywords
- weight
- percentage
- pharmaceutical composition
- amino acid
- terramycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 21
- 238000009360 aquaculture Methods 0.000 title claims abstract description 19
- 244000144974 aquaculture Species 0.000 title claims abstract description 18
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 14
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 claims abstract description 24
- 229940063650 terramycin Drugs 0.000 claims abstract description 24
- 235000001014 amino acid Nutrition 0.000 claims abstract description 20
- -1 compound amino acid Chemical class 0.000 claims abstract description 16
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000004471 Glycine Substances 0.000 claims abstract description 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000004279 alanine Nutrition 0.000 claims abstract description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 5
- 239000004220 glutamic acid Substances 0.000 claims abstract description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
- 241000251468 Actinopterygii Species 0.000 description 11
- 239000003814 drug Substances 0.000 description 6
- 241000252210 Cyprinidae Species 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical group C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 4
- 241000252233 Cyprinus carpio Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000013505 freshwater Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000252230 Ctenopharyngodon idella Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 241000252234 Hypophthalmichthys nobilis Species 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 1
- 241001275898 Mylopharyngodon piceus Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 241000276701 Oreochromis mossambicus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种降低抗生素残留的水产养殖用药物组合物,其特征是所述药物组合物由作为活性成分的土霉素与复合氨基酸和作为赋形剂的可以用于制作饵料的辅料组成,所述土霉素与复合氨基酸的质量比为1:0.3~0.8,所述的复合氨基酸由重量百分比7%‑~9%的谷氨酸,重量百分比18%~22%的丙氨酸,重量百分比14%~16%的亮氨酸,重量百分比8%~10%的丝氨酸,重量百分比3%~4%的N‑乙酰L‑色氨酸和余量甘氨酸组成。
Description
技术领域
本发明属于水产药物,具体的说涉及一种鱼药。
背景技术
四环素类抗生素由于其成本低廉、疗效确定且既可以加入饵料用于口服,又可以用于水体消毒,因此在水产养殖中得到了广泛的应用。但由于土霉素的使用会产生“四环素牙”等严重问题,已经禁止用于人类口服。现有水产养殖技术中,在应用土霉素时一般需要长达30d的休药期才能使其在水产品体内的残留降至100μg/kg以下,土霉素在水产养殖应用存在着较为严重的限制,因此提供一种能够降低土霉素在水产品体内残留的用于水产养殖的药物组合物成为现有技术中亟待解决的问题。
发明内容
为解决前述技术问题,本发明提供了了一种降低抗生素残留的水产养殖用药物组合物,其特征是所述药物组合物由作为活性成分的土霉素与复合氨基酸和作为赋形剂的可以用于制作饵料的辅料组成,所述土霉素与复合氨基酸的质量比为1:0.3~0.8,所述的复合氨基酸由重量百分比7%-~9%的谷氨酸,重量百分比18%~22%的丙氨酸,重量百分比14%~16%的亮氨酸,重量百分比8%~10%的丝氨酸,重量百分比3%~4%的N-乙酰L-色氨酸和余量甘氨酸组成。
所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述土霉素与复合氨基酸的质量比为1:0.4~0.6。
所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述复合氨基酸由重量百分比8%的谷氨酸,重量百分比20%的丙氨酸,重量百分比15%的亮氨酸,重量百分比10%的丝氨酸,重量百分比3%的N-乙酰L-色氨酸和余量甘氨酸组成。
所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述药物组合物用于鲤科的淡水鱼的养殖。
所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述鲤科的淡水鱼优选青鱼、草鱼、鲢鱼、鳙鱼、鲤鱼、鲫鱼、罗非鱼。
本发明提供的一种降低抗生素残留的水产养殖用药物组合物,通过优选土霉素与复合氨基酸的之间的配比以及复合氨基酸中各氨基酸配比,意外的发现将活性成分与作为赋形剂的可以用于制作饵料的辅料混合对水产养殖鱼类进行饲喂给药时,除了可以正常发挥土霉素的抗生素作用外,还能够显著的降低鱼只体内的土霉素残留,在土霉素给药结束后单独给予含有复合氨基酸的饵料时,则可以进一步提高土霉素在鱼只体内的代谢速度,从而可以大幅度减少土霉素药物在应用于水产养殖时的休药期。解决了现有技术的问题,尤其在应用于鲤科淡水鱼的养殖。尤其是在复合氨基酸选取时,我们发现在甘氨酸、丙氨酸和亮氨酸的基础上,加入谷氨酸、丝氨酸和少量的N-乙酰L-色氨酸后其降低抗生素效果更为明显。
具体实施方式
本发明提供的一种降低抗生素残留的水产养殖用药物组合物,以如下方法配制,
1)将作为活性成分的土霉素、复方氨基酸与作为赋形剂的可以用于制作饵料的辅料混合
2)将步骤1)的混合物中加水混匀后压制成条状干燥后即得本发明的药物组合物。
本具体实施方式中采用的可用于制作饵料的辅料的配方为:
鱼粉8%,豆粕13%,花生粕18.8%,棉粕13%,菜籽粕13%,豆油4%,预混料1%,面粉13%,米糠7%,麸皮8%,麦饭石1.2%(以上百分比为饵料中各组分占饵料的重量百分比)
所述预混料采用北京博达生物饲料有限公司生产的鲤鱼1%预混料,每g预混料含有以下营养成分:
维生素A≥400IU,维生素D3100~300IU,维生素E≥7mg,维生素K3≥0.2mg,维生素B1≥0.3mg、维生素B2≥0.5mg、维生素B6≥0.22mg,烟酰胺≥2.5mg、泛酸钙≥2mg、叶酸≥0.2mg、维生素C≥8mg,肌醇≥7mg、铁8~75mg、铜0.875~2.5mg、锌7~20mg、锰2~10mg、碘≥0.03mg、硒0.01~0.05mg,钴0.01~0.2mg。
实施例1~6的配方如下
对比例1~6,分别与实施例1~6配方相同,但不加入土霉素
药理实施例
采用健康的幼年鲤鱼,初始体重14.02±0.48g,分为实验组1~6及对照组,实验组1~6分别投喂实施例1~6得到的药物组合物,对照组将可用于制作饵料的辅料作为常规饵料进行投喂。
试验塘为86cm×56cm×48cm的塑料池,每池放养25尾鲤鱼,每组1池。饲喂方法为将制成的药物组合物作为饵料每天投喂两次,时间分别为9:00和18:00,每次喂量约为鱼体重的3%,折合土霉素给药量为60mh/kg体重,投喂时间为5d,实验结束后每池随机取5尾试验鱼,对其进行体内土霉素残留量检测,然后对实验组1~6继续饲喂无土霉素的对比例组合物,对照组继续只喂无活性成分的常规饵料,持续5d后每组再随机取5尾试验用鱼进行体内土霉素残留量检测,以实验组饲养5d后对照组鱼只的体内土霉素平均残留量为100,实验组1~6中土霉素残留量结果如下表。
编号 | 实验组1 | 实验组2 | 实验组3 | 实验组4 | 实验组5 | 实验组6 | 对照组 |
5d残留量 | 47 | 38 | 43 | 40 | 42 | 43 | 100 |
10d残留量 | 0.37 | 0.28 | 0.19 | 0.21 | 0.25 | 0.31 | 3.07 |
由此可见,采用本发明的药物组合物,可以显著减少土霉素在鱼只体内的残留,而且在停药后进一步饲喂只有复合氨基酸和饵料的对比例时,也能显著提高土霉素的代谢率。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均包含在本发明的保护范围之内。
Claims (3)
1.一种降低抗生素残留的水产养殖用药物组合物,其特征是所述药物组合物由作为活性成分的土霉素与复合氨基酸和作为赋形剂的可以用于制作饵料的辅料组成,所述土霉素与复合氨基酸的质量比为1:0.3~0.8,所述的复合氨基酸由重量百分比7%-~9%的谷氨酸,重量百分比18%~22%的丙氨酸,重量百分比14%~16%的亮氨酸,重量百分比8%~10%的丝氨酸,重量百分比3%~4%的N-乙酰L-色氨酸和余量甘氨酸组成。
2.如权利要求1所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述土霉素与复合氨基酸的质量比为1:0.4~0.6。
3.如权利要求1所述的一种降低抗生素残留的水产养殖用药物组合物,其特征是所述复合氨基酸由重量百分比8%的谷氨酸,重量百分比20%的丙氨酸,重量百分比15%的亮氨酸,重量百分比9%的丝氨酸,重量百分比3%的N-乙酰L-色氨酸和余量甘氨酸组成。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710497654.3A CN107281195A (zh) | 2017-06-27 | 2017-06-27 | 一种降低抗生素残留的水产养殖用药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710497654.3A CN107281195A (zh) | 2017-06-27 | 2017-06-27 | 一种降低抗生素残留的水产养殖用药物组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107281195A true CN107281195A (zh) | 2017-10-24 |
Family
ID=60098884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710497654.3A Pending CN107281195A (zh) | 2017-06-27 | 2017-06-27 | 一种降低抗生素残留的水产养殖用药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107281195A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110960541A (zh) * | 2019-12-13 | 2020-04-07 | 西南大学 | 一种用于南美白对虾的药物组合物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105192372A (zh) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | 一种青鱼预混饲料及其制备方法 |
-
2017
- 2017-06-27 CN CN201710497654.3A patent/CN107281195A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105192372A (zh) * | 2015-09-28 | 2015-12-30 | 全椒县花溪湖特种水产合作社 | 一种青鱼预混饲料及其制备方法 |
Non-Patent Citations (1)
Title |
---|
付同禄等: "饲料添加剂现状及在鱼虾饲料中的利用", 《饲料工业》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110960541A (zh) * | 2019-12-13 | 2020-04-07 | 西南大学 | 一种用于南美白对虾的药物组合物 |
CN110960541B (zh) * | 2019-12-13 | 2022-10-28 | 西南大学 | 一种用于南美白对虾的药物组合物 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Daniel | A review on replacing fish meal in aqua feeds using plant protein sources | |
CN104938866B (zh) | 一种抗仔猪应激和改善肠道的饲料添加剂及制备方法与应用 | |
US10178871B2 (en) | Herbaceous selenium-enriched SOD non-antibiotic feed and method of manufacture thereof | |
Murthy et al. | Total sulphur amino acid requirement of the Indian major carp, Labeo rohita (Hamilton) | |
CN104351478A (zh) | 一种复合型功能性氨基酸饲料添加剂与应用 | |
EP2880989A1 (en) | Foodstuff for cultured fish and method for promoting growth of cultured fish using same | |
RU2352139C2 (ru) | Способ повышения прочности костей у свиней, соответствующая композиция, ее применение, кормовой продукт и премикс для свиней | |
CN101536733A (zh) | 一种无抗生素无腥味低脂肪肉食鸭专用饲料 | |
ES2896260T3 (es) | Sal conjugada de ácido de N,N-dimetilglicina y ácido orgánico, y composición y aplicación de la misma | |
ES2907015T3 (es) | Sal compuesta de N,N-dimetilglicina y un ácido orgánico y composición y uso de la misma | |
CN106689696A (zh) | 一种肉鸡预混合饲料 | |
CN107158009A (zh) | 一种用于水产养殖的药物组合物 | |
CN107375305A (zh) | 一种能够减少抗生素残留的鱼用药物组合物 | |
CN107281195A (zh) | 一种降低抗生素残留的水产养殖用药物组合物 | |
KR100897488B1 (ko) | 적색 셰일 함유 가축사료 조성물 | |
KR101684462B1 (ko) | 울금 및 스테비아의 혼합물을 유효성분으로 포함하는 뱀장어 생육증진용 사료첨가제 조성물 | |
EP4378320A1 (en) | Use of furan formic acid compound in preparing animal feed additive | |
CN107281194A (zh) | 一种用于鱼类养殖的复方药物 | |
CN107080111A (zh) | 一种用于水产品养殖的饵料型药物 | |
CN107158010A (zh) | 一种鱼药 | |
CN107568457A (zh) | 一种替代抗生素和氧化锌降低断奶仔猪腹泻率的饲料 | |
CN107174588A (zh) | 一种用于鱼类养殖的药物 | |
CN107212155A (zh) | 一种用于鲤科家鱼养殖的药物组合物 | |
CN107569497A (zh) | 一种用于鲤科水产品养殖的饵料型药物 | |
Patil et al. | Growth performance and survival of common carp (Cyprinus carpio Linnaeus, 1758) fingerlings fed with protease enzyme supplemented diet |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171024 |
|
WD01 | Invention patent application deemed withdrawn after publication |