CN107280810A - A kind of degradable mammary gland support - Google Patents
A kind of degradable mammary gland support Download PDFInfo
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- CN107280810A CN107280810A CN201710353745.XA CN201710353745A CN107280810A CN 107280810 A CN107280810 A CN 107280810A CN 201710353745 A CN201710353745 A CN 201710353745A CN 107280810 A CN107280810 A CN 107280810A
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- Prior art keywords
- mammary gland
- degradable
- dimensional
- gland support
- linear
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses and implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Prostheses (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
Abstract
A kind of degradable mammary gland support, it is made up of three-dimensional boundaries structure and internal interstitital texture, the appearance profile of three-dimensional boundaries structure matches with being implanted the actual tumour appearance profile of patient, the appearance profile of three-dimensional boundaries structure on the basis of actual tumour outline, along normal outside direction extend 1~5mm；Internal interstitital texture includes three dimensional elasticity cell array, and three dimensional elasticity cell array forms degradable mammary gland support after intersecting with three-dimensional boundaries structure；Breast shape can not only be repaired after present invention implantation human body, and with good integral, flexible, the deformation behavior to simulate natural breast tissue；Its unique loose structure is grown into beneficial to histocyte, is solved mammary gland implant and is come off, shifts equivalent risk；With the degraded of support, autologous tissue gradually substitutes supporting structure, finally realizes autogenous repairing.
Description
Technical field
The present invention relates to organizational project and Biotechnology field, and in particular to a kind of degradable degradable mammary gland branch
Frame.
Background technology
In recent years, the cancer hair of China is continuously increased, breast cancer is the most common cancer of Chinese women, and breast cancer is controlled
Treatment need to typically carry out mammary gland or mastectomy, and coordinate the radiotherapy in later stage.And the excision of mammary gland or breast is not except
Outside beneficial to the physiological health of patient, patient body outward appearance and mental health can be also directly influenced, is made troubles to daily life.
For this problem, breasst reconstruction operation can reproduce breast for patient, so as to improve the adverse effect that resection operation is brought.
Different according to the species of implant, breasst reconstruction operation can be divided into autograft and be transplanted with prosthese.Wherein, certainly
Body tissue transplantation has the advantages that no rejection, strong sense of reality；But, shortcoming absorbing to there is autologous tissue, needing multiple hand
The problems such as art.And although prosthese transplanting can realize preferable breasst reconstruction effect, existing prosthetic material is with Silica hydrogel
It based on material, can not be degraded after implantation human body is interior, exist and come off, shift equivalent risk, influence post-operative recovery.
The content of the invention
In order to overcome the shortcoming of above-mentioned prior art, it is an object of the invention to provide a kind of degradable mammary gland support, plant
Breast shape can not only be repaired by entering after human body, and with good integral, flexible, the deformation to simulate natural breast tissue
Characteristic；Its unique loose structure is grown into beneficial to histocyte, is solved mammary gland implant and is come off, shifts equivalent risk；With branch
The degraded of frame, autologous tissue gradually substitutes supporting structure, finally realizes autogenous repairing.
To achieve these goals, the technical scheme is that：
A kind of degradable mammary gland support, is made up of three-dimensional boundaries structure and internal interstitital texture, outside three-dimensional boundaries structure
Shape profile matches with being implanted the actual tumour appearance profile of patient, and the appearance profile of three-dimensional boundaries structure is with actual tumour foreign steamer
On the basis of exterior feature, along normal outside direction extend 1~5mm；Internal interstitital texture is three dimensional elasticity cell array, three dimensional elasticity unit battle array
Row form degradable mammary gland support after intersecting with three-dimensional boundaries structure.
The described actual tumour appearance profile of patient that is implanted is obtained by extracting the medical image data of patient.
Described three-dimensional boundaries structure is the occluding surface structure of perforated grill formation, and network angle is 30~150
Degree, grid cell minimum feature is 0.2~2mm, and pore size is 2~10mm；
Described three dimensional elasticity unit is the solid that the linear with scalability is intersected to form in tri- directions of XYZ
Unit, the form of linear includes：Trigonometric function, class trigonometric function shape linear or space spiral curved linear lines knot
Structure；The minimum feature of linear is 0.2~2mm, and the size dimension of stereo-unit is 5~12mm；Trigonometric function or class triangle
The amplitude of function shape linear is 0.3~4mm, and the screw diameter of spatially spiral curve is 0.3~6mm.
The array direction of described three dimensional elasticity cell array is consistent with the grid array direction of three-dimensional boundaries structure,
And it is crossed to form complete inside interstitital texture with degradable mammary gland support outline border.
The material that described degradable mammary gland support is used is Biodegradable material, and Biodegradable material includes gathering oneself
Lactone (PCL), PLA (PLA) and Poly(D,L-lactide-co-glycolide (PLGA).
Described degradable mammary gland support is made using 3D printing technique or die perfusion method.
The advantage of the invention is that：
1. the degradable mammary gland supporting structure of the present invention can cause minimum with the actual tumour perfect matching of patient to patient
Tumor region is completely covered under conditions of injury；
2. the degradable mammary gland supporting structure of the present invention not only possesses good enabling capabilities, and with the true breast of simulation
The elastic characteristic of room tissue, meets attractive in appearance, functional need of the patient to breasst reconstruction；
3. the porous network structure that the degradable mammary gland support of the present invention is used is grown into suitable for histocyte, can effectively it solve
The problems such as mammary gland implant comes off, shifted；
4. the degradable mammary gland support of the present invention has good biodegradability, with the degraded of support, autologous group
Support can be substituted completely by knitting, and be finally completed breast reparation.
Brief description of the drawings
Fig. 1 is the tumor model extracted according to the medical image data of patient.
Fig. 2 is the degradable mammary gland support mesh shell that embodiment one is matched with tumor model.
Fig. 3 is the sine curve linear three dimensional elasticity unit of embodiment one.
Fig. 4 is interstitital texture inside the degradable mammary gland support sinusoidal of embodiment one.
Fig. 5 is the degradable mammary gland support of embodiment one.
Fig. 6 is the degradable mammary gland support mesh shell that embodiment two is matched with tumor model.
Fig. 7 is the spiral curve configuration three dimensional elasticity unit of embodiment two.
Fig. 8 is interstitital texture inside the degradable mammary gland stent helix shaped form of embodiment two.
Fig. 9 is the degradable mammary gland support of embodiment two.
Embodiment
Below in conjunction with drawings and examples, the present invention is described in detail.
Embodiment one
A kind of degradable mammary gland support, is made up of three-dimensional boundaries structure and internal interstitital texture, outside three-dimensional boundaries structure
Shape profile matches with being implanted the actual tumour appearance profile of patient, to ensure that tumor region, three-dimensional boundaries is completely covered in support
The appearance profile of structure on the basis of actual tumour outline, along normal outside direction extension 2mm；Internal interstitital texture includes three-dimensional
Flexible element array, three dimensional elasticity cell array forms degradable mammary gland support after intersecting with three-dimensional boundaries structure.
The described actual tumour appearance profile of patient that is implanted is obtained by extracting the medical image data of patient, such as Fig. 1
It is shown；
Described three-dimensional boundaries structure is the occluding surface structure of perforated grill formation, and network angle is 90 degree, net
Lattice unit minimum feature is 1mm, and pore size is 8mm, as shown in Figure 2；
Described three dimensional elasticity unit is the solid that the linear with scalability is intersected to form in tri- directions of XYZ
Unit, linear is the sine line bar structure intersected on tri- directions of XYZ, and sine curve amplitude is 2mm, and line width is 1mm, single
The Outside Dimensions of meta structure are 9mm*9mm*9mm, as shown in Figure 3；
The array direction of described three dimensional elasticity cell array is consistent with the grid array direction of three-dimensional boundaries structure,
And complete inside interstitital texture is crossed to form with degradable mammary gland support outline border, as shown in Figure 4；
Described degradable mammary gland support is intersected by the three-dimensional boundaries structure of degradable mammary gland support with internal interstitital texture
Composition, as shown in Figure 5；
The material that described degradable mammary gland support is used is Biodegradable material, and Biodegradable material includes gathering oneself
Lactone (PCL), PLA (PLA) and Poly(D,L-lactide-co-glycolide (PLGA).
Described degradable mammary gland support is made using 3D printing technique or die perfusion method.
Embodiment two：
A kind of degradable mammary gland support, is made up of three-dimensional boundaries structure and internal interstitital texture, outside three-dimensional boundaries structure
Shape profile matches with being implanted the actual tumour appearance profile of patient, to ensure that tumor region, three-dimensional boundaries is completely covered in support
The appearance profile of structure on the basis of actual tumour outline, along normal outside direction extension 2mm；Internal interstitital texture includes three-dimensional
Flexible element array, three dimensional elasticity cell array forms degradable mammary gland support after intersecting with three-dimensional boundaries structure.
The described actual tumour appearance profile of patient that is implanted is obtained by extracting the medical image data of patient, such as Fig. 1
It is shown；
Described three-dimensional boundaries structure is the occluding surface structure of perforated grill formation, and network angle is 90 degree, net
Lattice unit minimum feature is 1.5mm, and pore size is 10mm, as shown in Figure 6；
Described three dimensional elasticity unit is the solid that the linear with scalability is intersected to form in tri- directions of XYZ
Unit, linear is the spatially spiral curvilinear structures intersected on tri- directions of XYZ, and screw diameter is 5mm, and line width is 1mm, single
The Outside Dimensions of meta structure are 12mm*12mm*12mm, as shown in Figure 7；
The array direction of described three dimensional elasticity cell array is consistent with the grid array direction of three-dimensional boundaries structure,
And complete inside interstitital texture is crossed to form with degradable mammary gland support outline border, as shown in Figure 8；
Described degradable mammary gland support is intersected by the three-dimensional boundaries structure of degradable mammary gland support with internal interstitital texture
Composition, as shown in Figure 9；
The material that described degradable mammary gland support is used is Biodegradable material, and Biodegradable material includes gathering oneself
Lactone (PCL), PLA (PLA) and Poly(D,L-lactide-co-glycolide (PLGA).
Described degradable mammary gland support is made using 3D printing technique or die perfusion method.
Claims (7)
1. a kind of degradable mammary gland support, it is characterised in that：It is made up of three-dimensional boundaries structure and internal interstitital texture, three-dimensional boundaries
The appearance profile of structure matches with being implanted the actual tumour appearance profile of patient, and the appearance profile of three-dimensional boundaries structure is with reality
On the basis of tumour outline, along normal outside direction extend 1~5mm；Internal interstitital texture includes three dimensional elasticity cell array, three-dimensional
Flexible element array forms degradable mammary gland support after intersecting with three-dimensional boundaries structure.
2. a kind of degradable mammary gland support according to claim 1, it is characterised in that：It is described to be implanted that patient is actual to swell
Knurl appearance profile is obtained by extracting the medical image data of patient.
3. a kind of degradable mammary gland support according to claim 1, it is characterised in that：Described three-dimensional boundaries structure is many
The occluding surface structure of grid of holes formation, network angle is 30~150 degree, and grid cell minimum feature is 0.2~2mm,
Pore size is 2~10mm.
4. a kind of degradable mammary gland support according to claim 1, it is characterised in that：Described three dimensional elasticity unit is tool
The stereo-unit that the linear for having scalability is intersected to form in tri- directions of XYZ, the form of linear includes：Triangle letter
Number, class trigonometric function shape linear or space spiral curved linear linear；The minimum feature of linear is 0.2~2mm,
The size dimension of stereo-unit is 5~12mm；The amplitude of trigonometric function or class trigonometric function shape linear is 0.3~4mm, empty
Between helical curve screw diameter be 0.3~6mm.
5. a kind of degradable mammary gland support according to claim 1, it is characterised in that：Described three dimensional elasticity cell array
Array direction and the grid array direction of three-dimensional boundaries structure be consistent, and with degradable mammary gland support outline border phase
Friendship forms complete inside interstitital texture.
6. a kind of degradable mammary gland support according to claim 1, it is characterised in that：Described degradable mammary gland support is adopted
Material is Biodegradable material, Biodegradable material include polycaprolactone (PCL), PLA (PLA) and PLA-
Co-glycolic acid (PLGA).
7. a kind of degradable mammary gland support according to claim 1, it is characterised in that：Described degradable mammary gland support is adopted
Made of 3D printing technique or die perfusion method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710353745.XA CN107280810B (en) | 2017-05-18 | 2017-05-18 | A kind of degradable mammary gland holder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710353745.XA CN107280810B (en) | 2017-05-18 | 2017-05-18 | A kind of degradable mammary gland holder |
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| Publication Number | Publication Date |
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| CN107280810A true CN107280810A (en) | 2017-10-24 |
| CN107280810B CN107280810B (en) | 2018-11-09 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853596A (en) * | 2018-07-25 | 2018-11-23 | 哈尔滨工业大学 | A kind of shape-memory polymer breast bracket and preparation method thereof |
| CN109172044A (en) * | 2018-07-24 | 2019-01-11 | 西安交通大学 | A kind of degradable gradient-porosity mammary gland bracket |
| CN111113750A (en) * | 2019-02-20 | 2020-05-08 | 上海康宁医疗用品有限公司 | Method for manufacturing breast prosthesis external capsule with built-in PLA silk screen |
| CN113180883A (en) * | 2020-11-03 | 2021-07-30 | 复旦大学附属肿瘤医院 | Degradable breast-protecting bracket |
| CN114599315A (en) * | 2019-09-04 | 2022-06-07 | 贝拉塞诺有限公司 | Soft tissue reconstruction implants and methods of forming same |
| CN115605235A (en) * | 2020-03-22 | 2023-01-13 | 科弗朗有限公司（Il） | Collagen-based formulations useful as soft tissue fillers and/or implants |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1913929A (en) * | 2003-12-10 | 2007-02-14 | 细胞生物工程公司 | Methods and composition for soft tissue feature reconstruction |
| US20070185575A1 (en) * | 2006-02-08 | 2007-08-09 | Bobby Purkait | Breast implant and method of manufacture |
| KR20080095023A (en) * | 2007-04-23 | 2008-10-28 | 박재영 | Silicone sponge medical implant made by using gas-bubble and the method for fixing it |
| CN101658444A (en) * | 2009-01-22 | 2010-03-03 | 徐国风 | Breast prosthesis with supporting traction belt |
| CN101850132A (en) * | 2009-03-31 | 2010-10-06 | 中山大学附属第一医院 | Tissue engineering breast implant and construction method thereof |
| CN102470032A (en) * | 2009-07-21 | 2012-05-23 | 生命细胞公司 | Graft materials for surgical breast procedures |
| US20120130490A1 (en) * | 2010-09-24 | 2012-05-24 | Dominique Erni | Method for reconstruction and augmentation of the breast |
| CN103393482A (en) * | 2013-08-14 | 2013-11-20 | 北京瑞健高科生物科技有限公司 | Breast implant support device based on periplast material and preparation method thereof |
| WO2014118773A1 (en) * | 2013-01-30 | 2014-08-07 | Implite Ltd. | Human implantable tissue expanders |
| CN104127260A (en) * | 2014-08-15 | 2014-11-05 | 湖北省肿瘤医院 | Quantitative selecting method for postmastectomy immediate implant reconstruction |
| CN104783924A (en) * | 2015-04-24 | 2015-07-22 | 杭州捷诺飞生物科技有限公司 | Breast prosthesis manufacturing method based on three-dimensional printing technology |
| CN106073943A (en) * | 2016-07-19 | 2016-11-09 | 青岛三帝生物科技有限公司 | The antiseep breast prosthesis forming method printed based on 3D and breast prosthesis |
| CN106420108A (en) * | 2016-11-01 | 2017-02-22 | 青岛大学附属医院 | Manufacturing method for individual breast prosthesis based on breast digital image fusion technique |
-
2017
- 2017-05-18 CN CN201710353745.XA patent/CN107280810B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1913929A (en) * | 2003-12-10 | 2007-02-14 | 细胞生物工程公司 | Methods and composition for soft tissue feature reconstruction |
| US20070185575A1 (en) * | 2006-02-08 | 2007-08-09 | Bobby Purkait | Breast implant and method of manufacture |
| KR20080095023A (en) * | 2007-04-23 | 2008-10-28 | 박재영 | Silicone sponge medical implant made by using gas-bubble and the method for fixing it |
| CN101658444A (en) * | 2009-01-22 | 2010-03-03 | 徐国风 | Breast prosthesis with supporting traction belt |
| CN101850132A (en) * | 2009-03-31 | 2010-10-06 | 中山大学附属第一医院 | Tissue engineering breast implant and construction method thereof |
| CN102470032A (en) * | 2009-07-21 | 2012-05-23 | 生命细胞公司 | Graft materials for surgical breast procedures |
| US20120130490A1 (en) * | 2010-09-24 | 2012-05-24 | Dominique Erni | Method for reconstruction and augmentation of the breast |
| WO2014118773A1 (en) * | 2013-01-30 | 2014-08-07 | Implite Ltd. | Human implantable tissue expanders |
| CN103393482A (en) * | 2013-08-14 | 2013-11-20 | 北京瑞健高科生物科技有限公司 | Breast implant support device based on periplast material and preparation method thereof |
| CN104127260A (en) * | 2014-08-15 | 2014-11-05 | 湖北省肿瘤医院 | Quantitative selecting method for postmastectomy immediate implant reconstruction |
| CN104783924A (en) * | 2015-04-24 | 2015-07-22 | 杭州捷诺飞生物科技有限公司 | Breast prosthesis manufacturing method based on three-dimensional printing technology |
| CN106073943A (en) * | 2016-07-19 | 2016-11-09 | 青岛三帝生物科技有限公司 | The antiseep breast prosthesis forming method printed based on 3D and breast prosthesis |
| CN106420108A (en) * | 2016-11-01 | 2017-02-22 | 青岛大学附属医院 | Manufacturing method for individual breast prosthesis based on breast digital image fusion technique |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172044A (en) * | 2018-07-24 | 2019-01-11 | 西安交通大学 | A kind of degradable gradient-porosity mammary gland bracket |
| CN108853596A (en) * | 2018-07-25 | 2018-11-23 | 哈尔滨工业大学 | A kind of shape-memory polymer breast bracket and preparation method thereof |
| CN111113750A (en) * | 2019-02-20 | 2020-05-08 | 上海康宁医疗用品有限公司 | Method for manufacturing breast prosthesis external capsule with built-in PLA silk screen |
| CN114599315A (en) * | 2019-09-04 | 2022-06-07 | 贝拉塞诺有限公司 | Soft tissue reconstruction implants and methods of forming same |
| US11529227B2 (en) | 2019-09-04 | 2022-12-20 | Bellaseno Gmbh | Implants and method for forming an implant |
| US11957567B2 (en) | 2019-09-04 | 2024-04-16 | Bellaseno Gmbh | Implants and method for forming an implant |
| CN115605235A (en) * | 2020-03-22 | 2023-01-13 | 科弗朗有限公司（Il） | Collagen-based formulations useful as soft tissue fillers and/or implants |
| CN113180883A (en) * | 2020-11-03 | 2021-07-30 | 复旦大学附属肿瘤医院 | Degradable breast-protecting bracket |
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| Publication number | Publication date |
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| CN107280810B (en) | 2018-11-09 |
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