CN107280786A - Can promotion organization reconstruction regeneration doctor material, its preparation method and operating method - Google Patents
Can promotion organization reconstruction regeneration doctor material, its preparation method and operating method Download PDFInfo
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- CN107280786A CN107280786A CN201610194336.5A CN201610194336A CN107280786A CN 107280786 A CN107280786 A CN 107280786A CN 201610194336 A CN201610194336 A CN 201610194336A CN 107280786 A CN107280786 A CN 107280786A
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- layer
- surface layer
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- tooth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
Abstract
Can promotion organization reconstruction regeneration doctor material, its preparation method and operating method the invention discloses one kind.This can promotion organization rebuild regeneration doctor material include intermediate layer, superficial layer, bottom surface layer and gelatine layer, superficial layer is arranged in the apparent surface in intermediate layer with bottom surface layer respectively, and superficial layer all has pothole with bottom surface layer surface, wherein superficial layer and its pothole are provided with antibacterial body, and bottom surface layer and its pothole are provided with reconstruction proteosome, again gelatine layer is combined with superficial layer capping, alveolar bone and gingival soft tissue hyperplasia are provided respectively with glue layer surface to rebuild proteosome, the root of the tooth of rapid firm implant tooth, reach that the root of the tooth of firm implant tooth shortens healing stage, gelatine layer, which is gradually degraded, slowly discharges antibacterial body sterilizing.
Description
Technical field
The present invention on can promotion organization rebuild regeneration doctor material, can promotion organization rebuild preparation method and the promotion organization of regeneration doctor's material and rebuild the operating method of regeneration doctor's material, foregoing alveolar bone when can operate with implant tooth rebuild with gum regenerate, bone fracture（Fracture）Reparation.
Background technology
Implant tooth is that artificial tooth root is implanted into alveolar bone, replaces whole dermal tooth with artificial tooth, removes it, laboratory rodent chow has the situation of identical dermal tooth.Implant toilet article have height to bear snap-in force, plant tooth person and there will not be oral foreign body sense, and do not injure the advantage of primary healthy tooth, and implant tooth, which gradually replaces, typically uses fixed artificial tooth or movable artificial tooth, and widely one of agomphosis person's selection dental filling mode.
Implementing implant tooth needs to be performed the operation by several times, first stage oral cavity reconstruction, by the dentium sculptura at agomphosis position and valve must be turned over, the alveolar bone in open surgery area, is understood bone conditions, is drilled on alveolar bone using Tooth transplantation device material, the cavities for being intended to implantable artificial root of the tooth size are produced depending on teeth groove bone width and height, further implantable artificial root of the tooth allows artificial tooth root to be embedded in alveolar bone and gum, last suture operation region in cavities.Because each Human alveolar bone condition is inconsistent, situation is poor, must carry out that maxilla nasal sinus increases art or bone meal is filled up to strengthen implant success rate.Second stage regards personal considerations' normally about integration period of 4 months to 6 months, and the artificial tooth of implant tooth after making the alveolar bone organization healing of artificial tooth root and surrounding firm, then dentium sculptura is locked to the artificial tooth root center for being embedded in alveolar bone again.
Because its integration period is tediously long after implantation root of the tooth, everyone treatment time difference again, therefore give whether inventor's research and development have correlation technique, material, gingival soft tissue, teeth groove bone uptake and firm plant sound of baby talk root can be promoted, shorten integration period and be up to six months in the past.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention provide one kind can promotion organization rebuild regeneration doctor material, it includes intermediate layer, superficial layer, bottom surface layer and gelatine layer, wherein：Intermediate layer is polyether-ether-ketone (PEEK, polyetheretherketone) material is made, and superficial layer is arranged in the apparent surface in intermediate layer with bottom surface layer respectively, and superficial layer all has the pothole that irregularity is arranged with bottom surface layer surface, wherein superficial layer and its pothole are provided with antibacterial body, and bottom surface layer and its pothole are provided with reconstruction proteosome, and gelatine layer is combined with superficial layer capping, wherein superficial layer, intermediate layer and bottom surface series of strata one.
Foregoing antibacterial body includes Hinokitiol (hinokitiol), sericin（sericin）Or organic silver (organic silver).Foregoing reconstruction proteosome includes I-type collagen (type I collagen), typeⅡ Collagen (collagen of type II), fibroin albumen（Fibroin）Or phosphatidyl fat alkali (Phosphatidylcholine).
Can promotion organization rebuild regeneration doctor material preparation method, it comprises the following steps：（a）PEEK is sulfonated, uses H2SO4（Sulfuric acid）+ acetone（Acetone, CH3COCH3）Cause PEEK both sides surface to produce cavernous hole with acid etching immersion, and define both sides difference superficial layer and bottom surface layer respectively, and superficial layer is then defined as intermediate layer between the two with bottom surface layer；（b）Antibacterial body is set with rebuilding proteosome, and antibacterial body sets superficial layer, bottom surface layer and its pothole respectively with rebuilding proteosome；（c）Glue is coated to, and degradable glue macromolecule is sealed up in superficial layer, forms it into gelatine layer and on superficial layer, and gelatine layer enclosed watch surface layer hole.
It is foregoing can promotion organization rebuild regeneration doctor material preparation method, wherein antibacterial body is arranged at superficial layer and bottom surface layer with rebuilding albumen system using microcapsule coated, or antibacterial body grafts on superficial layer and bottom surface layer with reconstruction proteosome with silanization, or antibacterial body is arranged at superficial layer and bottom surface layer with rebuilding proteosome with crosslinking agent.
It is foregoing can promotion organization rebuild regeneration doctor material operating method, wherein：The bottom surface layer of doctor's material is arranged on the root of the tooth of implant tooth, and bottom surface layer part is exposed on the outside of implant tooth and in gingival soft tissue, and extend towards alveolar bone direction, and it is located at the gelatine layer above the root of the tooth of implant tooth back to bottom surface layer, its gelatine layer is toward gingival soft tissue operation stitching direction.
It is foregoing can promotion organization rebuild regeneration doctor material operating method, wherein：Cure the bottom surface layer cladding bone split seam of material, around space, so that doctor's material coats the periphery side position of bone, and cure the gelatine layer of material towards muscular soft tissues direction.
The present invention provide can promotion organization rebuild regeneration doctor material, it can promote alveolar bone and gingival soft tissue hyperplasia, and then the root of the tooth of implant tooth can be consolidated rapidly, the root of the tooth for being rapidly reached firm implant tooth shortens healing stage, with more the effect for gradually slowly discharging antibacterial body sterilizing.
Brief description of the drawings
Fig. 1 is present invention doctor's material floor map.
Fig. 2 is that present invention doctor's material is used in implant tooth schematic diagram.
Fig. 3 is present invention doctor's material preparation method process block diagram.
Fig. 4 is that present invention doctor's material makes floor map.
Fig. 5 is that present invention doctor's material is used in bone fracture engagement schematic diagram.
Description of reference numerals：
1 doctor's material；11 intermediate layers；
12 superficial layers；121 potholes；
13 bottom surface layers；131 potholes；
2 gelatine layers；3 antibacterial bodies；
4 rebuild protein；51 gingival soft tissues；
52 alveolar bones；53 notches；
54 roots of the tooth；55 bone meal；
61 bones；62 bones；
63 muscular soft tissues.
Embodiment
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, so that those skilled in the art can be better understood from the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Refer to shown in schema Fig. 1, disclosed in figure the present invention can promotion organization rebuild regeneration doctor's material, doctor's material 1 includes intermediate layer 11, superficial layer 12, bottom surface layer 13 and gelatine layer 2, wherein：Intermediate layer 11 is polyether-ether-ketone (PEEK, polyetheretherketone) material is made, and superficial layer 12 is arranged in the apparent surface in intermediate layer 11 with bottom surface layer 13 respectively, and superficial layer 12 all has the pothole 121,131 that irregularity is arranged with the surface of bottom surface layer 13, wherein superficial layer 12 and its pothole 121 are provided with antibacterial body 3, and bottom surface layer 13 and its pothole 131 are provided with reconstruction proteosome 4, gelatine layer 2 is combined with the capping of superficial layer 12 again, wherein superficial layer 12, intermediate layer 11 and bottom surface layer 13 are integral.
Foregoing antibacterial body 3 includes Hinokitiol (hinokitiol), sericin（sericin）Or organic silver (organic silver).Foregoing reconstruction proteosome 4 includes I-type collagen (type I collagen), typeⅡ Collagen (collagen of type II), fibroin albumen（Fibroin）Or phosphatidyl fat alkali (Phosphatidylcholine).
Then referred to shown in Fig. 1 and Fig. 2 on occupation mode of the present invention, gingival soft tissue 51 is shown in figure to cut in advance, and emulated gum soft tissue 51 has the phenomenon of notch 53 in atrophy and the right side of alveolar bone 52 top, and the root of the tooth 54 for the implant tooth that locks in the centre position of alveolar bone 52, and foregoing notch 53 is separately filled up into bone meal 55, and then the bottom surface layer 13 for curing material 1 is arranged to the upper surface of root of the tooth 54 of implant tooth, and the part of bottom surface layer 13 exposes to the outside of root of the tooth 54 of implant tooth and is located in gingival soft tissue 51 and fills up between bone meal 55, and extend towards the direction of alveolar bone 52 and coat bone meal 55（The foregoing position of notch 53）, and it is located at the gelatine layer 2 of the top of root of the tooth 54 of implant tooth back to bottom surface layer 13, its gelatine layer 2 is finally able to suture gingival soft tissue 51 top position toward the operation stitching direction of gingival soft tissue 51（Figure is not shown）.So it is able to smoothly attract gingival soft tissue 51 in rebuilding regeneration herein by the surface of gelatine layer 2, and gelatine layer 2 can be slowly absorbed, therefore antibacterial body 3 is able to gradually be degraded in gelatine layer 2 and appeared, and then gradually can slowly discharge antibacterial body 3 to sterilize.And the pothole 131 by bottom surface layer 13 provides alveolar bone 52 with rebuilding proteosome 4（Bone meal 55）With gingival soft tissue hyperplasia, and then it can consolidate rapidly at the root of the tooth 54 of implant tooth, in this way, being able to reach that promotion gingival soft tissue 51 regenerates and alveolar bone 52 rebuilds regeneration, the root of the tooth 54 for being rapidly reached firm implant tooth shortens healing stage.
On it is foregoing can promotion organization rebuild regeneration doctor material preparation method, it comprises the following steps：（a）PEEK is sulfonated,（b）Antibacterial body with rebuild proteosome set and（c）Glue is coated to, and refers to Fig. 3 and Fig. 4, wherein：（a）PEEK is sulfonated, uses H2SO4（Sulfuric acid）+ acetone（Acetone, CH3COCH3）Cause PEEK both sides surface to produce cavernous hole with acid etching immersion, and define both sides difference superficial layer 12 and bottom surface layer 13 respectively, and superficial layer 12 is then defined as intermediate layer 11 between the two with bottom surface layer 13；（b）Antibacterial body is set with rebuilding proteosome, and antibacterial body 3 sets superficial layer 12, bottom surface layer 13 and its pothole 121,131 respectively with rebuilding proteosome 4；（c）Glue is coated to, and degradable glue macromolecule is sealed up in superficial layer 12, forms it into gelatine layer 2 and on superficial layer 12, and the hole 121 of the enclosed watch surface layer 12 of gelatine layer 2.
The present invention it is foregoing can promotion organization rebuild the operating method of regeneration doctor's material, be equally applicable for around bone split seam or bone space, and refer to shown in Fig. 5, there is crack before two side seams 61,62 are shown in figure（Space）Defect, and the week side of boss encirclement of bone 61,62 has muscular soft tissues 63, wherein：Cure the superficial layer 12 of material 1（The non-display surface layer 12 of figure）Around cladding bone split seam, space, so that doctor's material 1 coats the periphery side position of bone 61,62, and the gelatine layer 2 of material 1 is cured（Figure is not shown）Towards muscular soft tissues direction.In this way, equally doctor's material 1 connects two ends bone crack location in bone 61,62 crack locations formation closing hollow state just like tubing, and to cure the reconstruction proteosome 4 of material 1（Figure is not shown）Promote bone 61,62 to rebuild regeneration, and cure the gelatine layer 2 of material 1（Figure is not shown）Smooth surface, which provides muscular soft tissues 63 and seeks connections with to rebuild, to be regenerated, and is equally had and is shortened bone 61,62 cracks reconstruction regenerative healing phase.
It is worth mentioning that, the antibacterial body 3 of the present invention is to be arranged at superficial layer 12 and bottom surface layer 13 using microcapsule coated with rebuilding proteosome 4, or antibacterial body 3 grafts on superficial layer 12 and bottom surface layer 13 with reconstruction proteosome 4 with silanization, or antibacterial body 3 is arranged at superficial layer 12 and bottom surface layer 13 with rebuilding proteosome 4 with crosslinking agent.
Embodiment described above is only the preferred embodiment to absolutely prove the present invention and being lifted, protection scope of the present invention not limited to this.Equivalent substitute or conversion that those skilled in the art are made on the basis of the present invention, within protection scope of the present invention.Protection scope of the present invention is defined by claims.
Claims (7)
1. one kind can promotion organization rebuild regeneration doctor material, it is characterised in that include intermediate layer, superficial layer, bottom surface layer and gelatine layer, wherein：
Intermediate layer is made up of polyether-ether-ketone material, and superficial layer is arranged in the apparent surface in intermediate layer with bottom surface layer respectively, and superficial layer all has pothole with bottom surface layer surface, wherein superficial layer and its pothole are provided with antibacterial body, and bottom surface layer and its pothole are provided with reconstruction proteosome, gelatine layer is combined with superficial layer capping again, wherein superficial layer, intermediate layer and bottom surface layer is integral.
2. as claimed in claim 1 can promotion organization rebuild regeneration doctor material, it is characterised in that the antibacterial body includes Hinokitiol, sericin or organic silver.
3. as described in claim 1 or claim 2 can promotion organization rebuild regeneration doctor material, it is characterised in that the reconstruction proteosome includes I-type collagen, typeⅡ Collagen, fibroin albumen or phosphatidyl fat alkali.
4. as claimed in claim 1 can promotion organization rebuild regeneration doctor material preparation method, it is characterised in that comprise the following steps：
（a）Polyether-ether-ketone is sulfonated, uses H2SO4Cause PEEK both sides surface to produce cavernous hole with acid etching immersion with acetone, and define both sides difference superficial layer and bottom surface layer respectively, and superficial layer is then defined as intermediate layer between the two with bottom surface layer；
（b）Antibacterial body is set with rebuilding proteosome, and antibacterial body sets superficial layer, bottom surface layer and its pothole respectively with rebuilding proteosome；
（c）Glue is coated to, and degradable glue macromolecule is sealed up in superficial layer, forms it into gelatine layer and on superficial layer, and gelatine layer enclosed watch surface layer hole.
5. as claimed in claim 4 can promotion organization rebuild regeneration doctor material preparation method, it is characterized in that, antibacterial body is arranged at superficial layer and bottom surface layer with rebuilding proteosome using microcapsule coated, or antibacterial body grafts on superficial layer and bottom surface layer with reconstruction proteosome with silanization, or antibacterial body is arranged at superficial layer and bottom surface layer with rebuilding proteosome with crosslinking agent.
6. as claimed in claim 1 can promotion organization rebuild regeneration doctor material operating method, it is characterized in that, the bottom surface layer of doctor's material is arranged on the root of the tooth of implant tooth, and bottom surface layer part is exposed on the outside of implant tooth and in gingival soft tissue, and extend towards alveolar bone direction, and it is located at the gelatine layer above the root of the tooth of implant tooth back to bottom surface layer, its gelatine layer is toward gingival soft tissue operation stitching direction.
7. as claimed in claim 1 can promotion organization rebuild the operating method of regeneration doctor's material, it is characterised in that around the bottom surface layer cladding bone split seam of doctor's material, space, so that doctor's material coats the periphery side position of bone, and cure the gelatine layer of material towards muscular soft tissues direction.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610194336.5A CN107280786A (en) | 2016-03-31 | 2016-03-31 | Can promotion organization reconstruction regeneration doctor material, its preparation method and operating method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610194336.5A CN107280786A (en) | 2016-03-31 | 2016-03-31 | Can promotion organization reconstruction regeneration doctor material, its preparation method and operating method |
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| CN107280786A true CN107280786A (en) | 2017-10-24 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515232A (en) * | 2003-01-09 | 2004-07-28 | 成都博联医疗信息产业有限责任公司 | Preparation method of medical film for dentistry |
| CN101511399A (en) * | 2006-09-08 | 2009-08-19 | 日本医疗器材有限公司 | Bioimplant |
| CN102113919A (en) * | 2009-12-30 | 2011-07-06 | 财团法人金属工业研究发展中心 | Human body implant and manufacturing method thereof |
| CN102316913A (en) * | 2008-12-29 | 2012-01-11 | 斯恩蒂斯有限公司 | A method of forming and the resulting membrane composition for surgical site preservation |
| CN202776621U (en) * | 2012-04-27 | 2013-03-13 | 温世政 | Composite regenerated film |
| CN104245004A (en) * | 2012-02-09 | 2014-12-24 | 高丽大学校产学协力团 | Antibiotics having antibacterial function for improved bone fusion, implant or scaffold emitting bone formation enhancing material, and method for manufacturing same |
-
2016
- 2016-03-31 CN CN201610194336.5A patent/CN107280786A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515232A (en) * | 2003-01-09 | 2004-07-28 | 成都博联医疗信息产业有限责任公司 | Preparation method of medical film for dentistry |
| CN101511399A (en) * | 2006-09-08 | 2009-08-19 | 日本医疗器材有限公司 | Bioimplant |
| CN102316913A (en) * | 2008-12-29 | 2012-01-11 | 斯恩蒂斯有限公司 | A method of forming and the resulting membrane composition for surgical site preservation |
| CN102113919A (en) * | 2009-12-30 | 2011-07-06 | 财团法人金属工业研究发展中心 | Human body implant and manufacturing method thereof |
| CN104245004A (en) * | 2012-02-09 | 2014-12-24 | 高丽大学校产学协力团 | Antibiotics having antibacterial function for improved bone fusion, implant or scaffold emitting bone formation enhancing material, and method for manufacturing same |
| CN202776621U (en) * | 2012-04-27 | 2013-03-13 | 温世政 | Composite regenerated film |
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Application publication date: 20171024 |