CN107262169A - Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed - Google Patents
Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed Download PDFInfo
- Publication number
- CN107262169A CN107262169A CN201710481604.6A CN201710481604A CN107262169A CN 107262169 A CN107262169 A CN 107262169A CN 201710481604 A CN201710481604 A CN 201710481604A CN 107262169 A CN107262169 A CN 107262169A
- Authority
- CN
- China
- Prior art keywords
- micro
- fluidic chip
- negative pressure
- vacuum chamber
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A kind of negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, belong to micro-fluidic chip sampling device.Its suction negative pressure device for including micro-fluidic chip and being connected with micro-fluidic chip, inhaling negative pressure device includes vacuum chamber and the spring mechanical pump being connected with vacuum chamber, spring mechanical pump is located above vacuum chamber, the microfluidic channel output end connection of vacuum chamber and micro-fluidic chip, micro-fluidic chip is provided with sample cell, vortex mixed sample pool and detection zone, each sample cell is communicated with vortex mixed sample pool, and vortex mixed sample pool is connected by the microfluidic channel input of micro-fluidic chip with detection zone.The present invention drives the spontaneous vasomotion of microfluid sample using the negative pressure of spring mechanical pumping vacuum chamber formation, utilize the uniform mixing that detection sample and liquid storage tank buffer solution are realized in the presence of micro-whirlpool valve in vortex mixed sample pool, it is ensured that enter the homogeneity of detection zone sample.
Description
Technical field
The invention belongs to micro-fluidic chip sampling device, and in particular to negative pressure driving, the micro-fluidic chip machine for the mixing that is vortexed
Tool formula Ngatively pressurized sampling device.
Background technology
Micro-fluidic chip sample preparation, reaction, is divided by the manipulation and control to microfluid in chip microchannel network
From process integration such as, detections on the chip of one piece of micro-meter scale, analysis overall process is automatically performed, it is analyzed required for sample
Only several microlitres to tens microlitres of amount of reagent, the volume of analyzed material is even in nanoliter level or picoliters level.It is simultaneously micro-fluidic
Chip can integrated plurality of cells part, can largely parallel processing sample, the characteristics of being detected with high flux.
Micro-fluidic chip micro fluid dynamcis mode includes Pneumatic Micropump driving, driven by electroosmosis, weight-driven, centrifugation driving
Power, shearing force etc., but it is expensive to equipment precision requirement height, manufacturing cost, and be unfavorable for carrying and detect in real time.The present invention relates to
A kind of negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, mainly realize micro-fluidic chip convenient type
Sample introduction and sample mixing, with low cost, the advantage detected with portability and in real time.
The content of the invention
The problem of existing for prior art, it is an object of the invention to design to provide a kind of negative pressure driving, vortex mixing
The mechanical Ngatively pressurized sampling device of micro-fluidic chip technical scheme.The device is formed using spring mechanical pumping vacuum chamber
Negative pressure drive microfluid sample spontaneous vasomotion, utilize in the presence of micro-whirlpool valve in vortex mixed sample pool realize detection sample
With the uniform mixing of liquid storage tank buffer solution, it is ensured that enter the homogeneity of detection zone sample.
A kind of described negative pressure drives, be vortexed the mechanical Ngatively pressurized sampling device of micro-fluidic chip mixed, it is characterised in that
The suction negative pressure device being connected including micro-fluidic chip and with micro-fluidic chip, the suction negative pressure device include vacuum chamber and with
Vacuum chamber connection spring mechanical pump, the spring mechanical pump be located at vacuum chamber above, the vacuum chamber with it is micro-fluidic
The microfluidic channel output end connection of chip, the micro-fluidic chip is provided with sample cell, vortex mixed sample pool and detection zone, each
Sample cell is communicated with vortex mixed sample pool, microfluidic channel input and detection zone that the vortex mixed sample pool passes through micro-fluidic chip
It is connected.
A kind of described negative pressure drives, be vortexed the mechanical Ngatively pressurized sampling device of micro-fluidic chip mixed, it is characterised in that
The spring mechanical pump connects branch joint, and the branch joint connects vacuum chamber, each vacuum chamber and fluidic chip
Microfluidic channel output end is corresponded.
A kind of described negative pressure drives, be vortexed the mechanical Ngatively pressurized sampling device of micro-fluidic chip mixed, it is characterised in that
The spring mechanical pump includes resilient engagement piston push rod in piston chamber, the piston chamber, and the piston chamber bottom is set
Have to be provided with the first silica gel check valve, the gas vent in gas access and gas vent, the gas access and be provided with second
Silica gel check valve.
A kind of described negative pressure drives, be vortexed the mechanical Ngatively pressurized sampling device of micro-fluidic chip mixed, it is characterised in that
The interface of the microfluidic channel output end of the vacuum chamber and micro-fluidic chip is provided with micro sealing circle.
A kind of described negative pressure drives, be vortexed the mechanical Ngatively pressurized sampling device of micro-fluidic chip mixed, it is characterised in that
The mixed uniformly micro-whirlpool valve of sample and liquid storage tank buffer solution can will be detected by being provided with the vortex mixed sample pool.
Compared with prior art, the invention has the advantages that：
1., manufacture high relative to driving equipment required precisions such as micro-fluidic chip microfluid Pneumatic Micropump, electric osmose, gravity, centrifugations
It is costly, and it is unfavorable for carrying and the shortcoming detected in real time, advantage of the invention is that injecting a sample into micro-fluidic chip
Sample cell after, spring mechanical pumping take vacuum chamber gas formation negative pressure of vacuum, be driven into liquid storage tank sample solution lead to
Cross microfluidic channel spontaneous vasomotion.Low production cost, the advantage detected with portability and in real time.
2. detect that sample and the mixed liquor of liquid storage tank buffer solution formation enter vortex sample mixing by microfluidic channel input
Pond, realizes the uniform mixing of detection sample and liquid storage tank buffer solution in vortex mixed sample pool in the presence of micro-whirlpool valve, it is ensured that
Into the homogeneity of detection zone sample.
3. the present invention uses Ngatively pressurized sampling, as long as there is one outlet, no matter there are several injection ports, all only need a coiling machine
Tool pump and vacuum chamber Ngatively pressurized sampling device can be completed.
4. wide adaptability of the present invention, is adapted to the micro-fluidic chip sample introduction of various channel types.
Brief description of the drawings
Fig. 1 is structural representation of the invention；
Fig. 2 is the structural representation of detection zone in the present invention；
Fig. 3 is the structural representation of spring mechanical pump in the present invention.
In figure：1- micro-fluidic chips；2- vortex mixed sample pools；3- sample cells；4- vacuum chambers；5- branch joints；6- springs
Mechanical pump；7- detection zones；101- microfluidic channel output ends；102- microfluidic channel inputs；601- piston push rods；602- lives
Fill in chamber；603-O type sealing rings；604- springs；605- the first silica gel check valves；606- the second silica gel check valves；607- gases
Entrance；608- gas vents.
Embodiment
The present invention is further illustrated below in conjunction with Figure of description.
As illustrated, a kind of negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, its feature exist
In the suction negative pressure device being connected including micro-fluidic chip 1 and with micro-fluidic chip 1.Inhale negative pressure device include vacuum chamber 4 and
The spring mechanical pump 6 being connected with vacuum chamber 4, spring mechanical pump 6 is located at the top of vacuum chamber 4.Spring mechanical pump 6 extracts vacuum
The gas formation negative pressure of chamber 4.In order to improve service efficiency, the connection branch joint 5 of spring mechanical pump 6, branch joint 5 is connected very
Plenum chamber 4, such spring mechanical pump 6 can realize the suction negative pressure to multiple vacuum chambers 4.Spring mechanical pump 6 includes plunger shaft
By the resilient engagement piston push rod 601 of spring 604 of setting in room 602, piston chamber 602, in order to ensure air-tightness, piston is pushed away
O-ring seal 603 is equipped between bar 601 and piston chamber 602.The bottom of piston chamber 602 is gentle provided with gas access 607
It is provided with body outlet 608, gas access 607 in the first silica gel check valve 605, gas vent 608 and is provided with the second silica gel check valve
606, wherein gas access 607 is connected with vacuum chamber 4 or branch joint 5.When spring mechanical pump 6 works, piston push rod is promoted
601, the second silica gel check valve 606 of gas vent 608 is opened, and the first silica gel check valve 605 at gas access 607 is closed,
Discharge the air in piston chamber 602；Piston push rod 601 is unclamped, piston push rod 601 is up moved in the presence of spring 604,
The second silica gel check valve 606 at gas vent 608 is closed, and the first silica gel check valve 605 of gas access 607 is opened, and is pumped into
New air, can so make to produce negative pressure in vacuum chamber 4.
Vacuum chamber 4 is connected with the microfluidic channel output end 101 of micro-fluidic chip 1, vacuum chamber 4 and micro-fluidic chip
The interface of 1 microfluidic channel output end 101 is provided with micro sealing circle, it is ensured that interface and the microfluidic channel of micro-fluidic chip 1 are defeated
Go out the sealing absorption of end 101, it is ensured that the negative pressure driving sample solution of the formation of vacuum chamber 2 enters detection zone 7 by microfluidic channel
Detected.
Micro-fluidic chip 1 is provided with sample cell 3, vortex mixed sample pool 2 and detection zone 7, each sample cell 3 and vortex mixed sample pool
2 are communicated, and vortex mixed sample pool 2 is connected by the microfluidic channel input 102 of micro-fluidic chip 1 with detection zone 7.Vortex sample mixing
The mixed uniformly micro-whirlpool valve of sample and liquid storage tank buffer solution can will be detected by being provided with pond 2.When in detection sample and storage
The mixed liquor of liquid pool buffer solution formation enters before the detection of detection zone 7, and mixed liquor is by vortex mixed sample pool 2, in micro-whirlpool valve
The lower uniform mixing for realizing detection sample and liquid storage tank buffer solution of effect.Microfluidic channel output end 101 and microfluidic channel are defeated
Enter the two ends that end 102 is located at detection zone 7.
During work, spring mechanical pump 6 inhales vacuum to vacuum chamber 4, in the presence of negative pressure, and the sample in sample cell 3 delays
Fliud flushing enters vortex mixed sample pool 2, and detection sample and liquid storage tank buffering are realized in the presence of the micro-whirlpool valve of vortex mixed sample pool 2
The uniform mixing of liquid, mixed liquor is detected under suction function into detection zone 7.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (5)
1. a kind of negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, it is characterised in that including miniflow
Control chip（1）And and micro-fluidic chip（1）The suction negative pressure device of connection, the suction negative pressure device includes vacuum chamber（4）And
With vacuum chamber（4）The spring mechanical pump of connection（6）, the spring mechanical pump（6）Positioned at vacuum chamber（4）Top, it is described true
Plenum chamber（4）With micro-fluidic chip（1）Microfluidic channel output end（101）Connection, the micro-fluidic chip（1）It is provided with sample
Product pond（3）, vortex mixed sample pool（2）And detection zone（7）, each sample cell（3）With vortex mixed sample pool（2）Communicate, described be vortexed is mixed
Sample pond（2）Pass through micro-fluidic chip（1）Microfluidic channel input（102）With detection zone（7）It is connected.
2. a kind of negative pressure driving as claimed in claim 1, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, its
It is characterised by the spring mechanical pump（6）Connect branch joint（5）, the branch joint（5）Connect vacuum chamber（4）, each
Vacuum chamber（4）With fluidic chip（1）Microfluidic channel output end（101）Correspond.
3. a kind of negative pressure driving as claimed in claim 1 or 2, the mechanical Ngatively pressurized sampling dress of the micro-fluidic chip mixed that is vortexed
Put, it is characterised in that the spring mechanical pump（6）Including piston chamber（602）, the piston chamber（602）Middle resilient engagement is lived
Fill in push rod（601）, the piston chamber（602）Bottom is provided with gas access（607）And gas vent（608）, the gas enters
Mouthful（607）In be provided with the first silica gel check valve（605）, the gas vent（608）In be provided with the second silica gel check valve（606）.
4. a kind of negative pressure driving as claimed in claim 1, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, its
It is characterised by the vacuum chamber（2）With micro-fluidic chip（1）Microfluidic channel output end（102）Interface provided with miniature close
Seal.
5. a kind of negative pressure driving as claimed in claim 1, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed, its
It is characterised by the vortex mixed sample pool（5）In provided with the mixed uniformly miniature whirlpool of sample and liquid storage tank buffer solution can will be detected
Stopcock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710481604.6A CN107262169A (en) | 2017-06-22 | 2017-06-22 | Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710481604.6A CN107262169A (en) | 2017-06-22 | 2017-06-22 | Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107262169A true CN107262169A (en) | 2017-10-20 |
Family
ID=60069065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710481604.6A Pending CN107262169A (en) | 2017-06-22 | 2017-06-22 | Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107262169A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109536364A (en) * | 2018-10-31 | 2019-03-29 | 深圳市尚维高科有限公司 | Micro-fluidic pcr chip and its operating method |
| CN109709041A (en) * | 2018-12-27 | 2019-05-03 | 天津昌和生物医药技术有限公司 | Dry analysis monochromatic light road Multichannel photoelectric detection device |
| CN112452365A (en) * | 2020-11-23 | 2021-03-09 | 无锡市夸克微智造科技有限责任公司 | Micro-machining fluid device |
| WO2023087179A1 (en) * | 2021-11-17 | 2023-05-25 | 深圳华大生命科学研究院 | Detection chip assembly tool, liquid injection apparatus and method, electronic device, and medium |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372182B1 (en) * | 1998-05-01 | 2002-04-16 | Aalto Scientific Ltd | Integrated body fluid collection and analysis device with sample transfer component |
| CN200955480Y (en) * | 2005-12-06 | 2007-10-03 | 孔庆林 | Hand-driven vacuum device |
| CN102872735A (en) * | 2012-09-19 | 2013-01-16 | 中国计量学院 | Mixer and microfluidic chip using same |
| CN103182334A (en) * | 2013-03-14 | 2013-07-03 | 上海交通大学 | Preparation method and application of electrochemical micro-fluidic sensing chip |
| CN203148758U (en) * | 2013-02-06 | 2013-08-21 | 深圳市第二人民医院 | Micro-fluidic chip for sample separation and detection |
| CN106582905A (en) * | 2017-01-12 | 2017-04-26 | 上海小海龟科技有限公司 | Sample introduction system for microfluid chips |
-
2017
- 2017-06-22 CN CN201710481604.6A patent/CN107262169A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372182B1 (en) * | 1998-05-01 | 2002-04-16 | Aalto Scientific Ltd | Integrated body fluid collection and analysis device with sample transfer component |
| CN200955480Y (en) * | 2005-12-06 | 2007-10-03 | 孔庆林 | Hand-driven vacuum device |
| CN102872735A (en) * | 2012-09-19 | 2013-01-16 | 中国计量学院 | Mixer and microfluidic chip using same |
| CN203148758U (en) * | 2013-02-06 | 2013-08-21 | 深圳市第二人民医院 | Micro-fluidic chip for sample separation and detection |
| CN103182334A (en) * | 2013-03-14 | 2013-07-03 | 上海交通大学 | Preparation method and application of electrochemical micro-fluidic sensing chip |
| CN106582905A (en) * | 2017-01-12 | 2017-04-26 | 上海小海龟科技有限公司 | Sample introduction system for microfluid chips |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109536364A (en) * | 2018-10-31 | 2019-03-29 | 深圳市尚维高科有限公司 | Micro-fluidic pcr chip and its operating method |
| CN109536364B (en) * | 2018-10-31 | 2021-07-23 | 深圳市尚维高科有限公司 | Microfluidic PCR chip and operation method thereof |
| CN109709041A (en) * | 2018-12-27 | 2019-05-03 | 天津昌和生物医药技术有限公司 | Dry analysis monochromatic light road Multichannel photoelectric detection device |
| CN112452365A (en) * | 2020-11-23 | 2021-03-09 | 无锡市夸克微智造科技有限责任公司 | Micro-machining fluid device |
| CN112452365B (en) * | 2020-11-23 | 2021-12-07 | 无锡市夸克微智造科技有限责任公司 | Micro-machining fluid device |
| WO2023087179A1 (en) * | 2021-11-17 | 2023-05-25 | 深圳华大生命科学研究院 | Detection chip assembly tool, liquid injection apparatus and method, electronic device, and medium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107262169A (en) | Negative pressure driving, the mechanical Ngatively pressurized sampling device of micro-fluidic chip for the mixing that is vortexed | |
| Park et al. | Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices | |
| US9044755B2 (en) | Gene analysis apparatus and gene analysis method using the same | |
| CN107541452B (en) | Microfluidic chip and chip assembly | |
| CN210012838U (en) | Nucleic acid extraction device with micro-flow channel | |
| CN210012837U (en) | Nucleic acid extraction device | |
| CN109536364B (en) | Microfluidic PCR chip and operation method thereof | |
| CN110308295B (en) | Microfluidic multichannel sample injection and cleaning device with same and cleaning method | |
| CN101458249B (en) | Microfluid example boat with solution storage chamber and pump structure | |
| TW201802383A (en) | Fluid control device | |
| JP6093783B2 (en) | Biochemical cartridge, biochemical cartridge and cartridge holder set | |
| CN102278293A (en) | Micropump based on capillarity action and using method thereof | |
| CN101424262A (en) | Sawtooth shape flow passage one-way piezoelectric micropump | |
| CN112980650A (en) | Vertical micro-fluidic chip and method for nucleic acid extraction | |
| Zhang et al. | On-demand control of microfluidic flow via capillary-tuned solenoid microvalve suction | |
| CN109488787A (en) | Fluid containment structure and micro-fluidic chip with the structure and its operating method | |
| WO2023040477A1 (en) | In-vitro diagnostic analysis apparatus and reagent kit | |
| CN112007705A (en) | Micro-droplet generating device | |
| CN106370878B (en) | A kind of negative pressure automatic sampling apparatus for micro-fluidic chip | |
| US8173078B2 (en) | Gravity-driven micropump | |
| WO2020098206A1 (en) | Microfluidic system suitable for liquid mixing, and method | |
| US6192939B1 (en) | Apparatus and method for driving a microflow | |
| CN217499275U (en) | Totally-enclosed nucleic acid detection chip | |
| CN113522383B (en) | Cell working condition device | |
| CN105736330A (en) | Medical micro-injection parallel micro-pump |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171020 |