CN107261217A - A kind of biological absorbable macromolecule nerve conduit stent and preparation method - Google Patents
A kind of biological absorbable macromolecule nerve conduit stent and preparation method Download PDFInfo
- Publication number
- CN107261217A CN107261217A CN201710609700.4A CN201710609700A CN107261217A CN 107261217 A CN107261217 A CN 107261217A CN 201710609700 A CN201710609700 A CN 201710609700A CN 107261217 A CN107261217 A CN 107261217A
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- CN
- China
- Prior art keywords
- nerve conduit
- conduit stent
- biological absorbable
- preparation
- macromolecule
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Abstract
The invention discloses biomedical material and a kind of biological absorbable macromolecule nerve conduit stent and preparation method in tissue engineering technique field, the structure of the biological absorbable macromolecule nerve conduit stent is tubular structure, the internal diameter of the tubular structure is 1.2 4.8mm, the aperture of the inner layer tube wall of the tubular structure is 0.3 10 μm, outer layer aperture is 20 100 μm, and the constituent of the biological absorbable macromolecule nerve conduit stent is：Poly epsilon caprolactone lactone, PLLA and polyhydroxyalkanoate, catheter holder is made of poly epsilon caprolactone lactone, PLLA and polyhydroxyalkanoate, improve the intensity and hardness of nerve conduit stent, the poly epsilon caprolactone lactone of addition can improve the elasticity of nerve conduit stent, so that the nerve conduit stent disclosure satisfy that radial support requirement, the preparation method for the nerve conduit stent that the invention is proposed, the degradation rate of nerve conduit stent is controllable, it is convenient to prepare, with good operability.
Description
Technical field
The present invention relates to biomedical material and tissue engineering technique field, specially a kind of biological absorbable macromolecule god
Through catheter holder and preparation method.
Background technology
Is there is sensory disturbance, motion by the region of the innervation in causing mainly due to a variety of causes for peripheral nerve injury
Obstacle and dystrophia.Peripheral nerve refers to the nerve beyond nervous centralis (brain and spinal cord).It include 12 pairs of cranial nerves, 31 pairs
Spinal nerve and autonomic nerve (sympathetic nerve, parasympathetic nerve).Modern medicine clinically have it is substantial amounts of because of contingency or
Malpractice and the patient for causing peripheral nerve injury, according to incompletely statistics, the nerve damage patient in the U.S. are big every year
About 469000 people, and Chinese population is about ten times of the U.S., patient's group's number is also very huge.At present clinically for nerve
The primary treatment regimen used is damaged for nerve autograft, although this method can effectively repair injured nerve, there is also
It is greatly not enough.On the one hand, the transplanting of autologous nerve certainly will damage the nerve in donor area；On the other hand, some damages is thick
Nerve can not be treated and repaired because can not find the graft that can be matched.Therefore, modern people gradually move eye
To the nerve trachea of nerve growth can be protected.Alternative materials transplanting refers mainly to biological absorbable polymer material being prepared into
Nerve trachea, biological absorbable high polymer material is widely used in the preparation of nerve trachea, and existing nerve is led
Hardness, intensity and the elastic performance of pipe holder can not meet using needs, and preparation method inconvenient operation, can cause support
Serious signs of degradation, therefore, it is proposed that a kind of biological absorbable macromolecule nerve conduit stent and preparation method.
The content of the invention
It is an object of the invention to provide a kind of biological absorbable macromolecule nerve conduit stent and preparation method, to solve
Hardness, intensity and the elastic performance of the existing nerve conduit stent proposed in above-mentioned background technology can not meet using needs,
And preparation method inconvenient operation, the problem of serious signs of degradation of support can be caused.
To achieve the above object, the present invention provides following technical scheme：A kind of biological absorbable macromolecule nerve trachea branch
Frame, the structure of the biological absorbable macromolecule nerve conduit stent is tubular structure, and the internal diameter of the tubular structure is 1.2-
4.8mm, the external diameter of the tubular structure is 1.5-5.3mm, and the aperture of the inner layer tube wall of the tubular structure is 0.3-10 μm, outside
Layer aperture is 20-100 μm, and the constituent of the biological absorbable macromolecule nerve conduit stent is：Poly epsilon caprolactone lactone, a poly- left side
Revolve lactic acid and polyhydroxyalkanoate.
It is preferred that, the molar content of the poly epsilon caprolactone lactone is 30%-45%, and the molar content of the PLLA is
30%-45%, the molar content of the polyhydroxyalkanoate is 10%-40%.
It is preferred that, a kind of preparation method of biological absorbable macromolecule nerve conduit stent, the biological absorbable macromolecule
The preparation method of nerve conduit stent comprises the following steps：
S1：PLLA that the poly epsilon caprolactone lactone for being 30%-45% by molar content, molar content are 30%-45% and
Molar content is added in organic solution for 10%-40% polyhydroxyalkanoate, stirring so that poly epsilon caprolactone lactone and poly- left-handed
Lactic acid fully dissolves；
S2：The solution obtained in step S1 is poured into strip mould, aseptically so that solution evaporation film forming,
By film production into 0.2-0.5mm filament；
S3：By the filament thermoset forming in step S2, biological absorbable is prepared according to the form for inserting body lumen in advance
Macromolecule nerve conduit stent.
It is preferred that, the organic solution in the step S1 is chloroformic solution.
It is preferred that, the preparation method of the filament in the step S2 is aperture extrusion molding.
It is preferred that, the temperature of thermoset forming is 40-100 degrees Celsius in the step S3.
Compared with prior art, the beneficial effects of the invention are as follows：A kind of biological absorbable macromolecule god that the invention is proposed
Through catheter holder and preparation method, catheter holder is made of poly epsilon caprolactone lactone, PLLA and polyhydroxyalkanoate, is carried
The high intensity and hardness of nerve conduit stent, the poly epsilon caprolactone lactone of addition can improve the elasticity of nerve conduit stent so that should
Nerve conduit stent disclosure satisfy that radial support requirement, the preparation method for the nerve conduit stent that the invention is proposed, nerve trachea
The degradation rate of support is controllable, and it is convenient to prepare, with good operability.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
The present invention provides a kind of biological absorbable macromolecule nerve conduit stent, the biological absorbable macromolecule nerve trachea
The structure of support is tubular structure, and the internal diameter of the tubular structure is 1.2-4.8mm, and the external diameter of the tubular structure is 1.5-
5.3mm, the aperture of the inner layer tube wall of the tubular structure is 0.3-10 μm, and outer layer aperture is 20-100 μm, and the biology can be inhaled
Receive macromolecule nerve conduit stent constituent be：Poly epsilon caprolactone lactone, PLLA and polyhydroxyalkanoate, the poly- ε
The molar content of caprolactone is 30%-45%, and the molar content of the PLLA is 30%-45%, the poly- hydroxyl fat
The molar content of fat acid esters is 10%-40%.
The present invention also provides a kind of preparation method of biological absorbable macromolecule nerve conduit stent：
Embodiment 1
The preparation method of the biological absorbable macromolecule nerve conduit stent comprises the following steps：
S1：The PLLA and molar content that the poly epsilon caprolactone lactone for being 42% by molar content, molar content are 42% be
16% polyhydroxyalkanoate is added in organic solution, stirring so that poly epsilon caprolactone lactone and PLLA fully dissolve, organic
Solution is chloroformic solution；
S2：The solution obtained in step S1 is poured into strip mould, aseptically so that solution evaporation film forming,
Filament of the aperture extrusion molding film production into 0.35mm will be used；
S3：By the filament thermoset forming in step S2, the temperature of thermoset forming is 70 degrees Celsius, according to inserting human body pipe in advance
The form of chamber prepares biological absorbable macromolecule nerve conduit stent.
Embodiment 2
The preparation method of the biological absorbable macromolecule nerve conduit stent comprises the following steps：
S1：The PLLA and molar content that the poly epsilon caprolactone lactone for being 35% by molar content, molar content are 45% be
20% polyhydroxyalkanoate is added in organic solution, stirring so that poly epsilon caprolactone lactone and PLLA fully dissolve, and have
Machine solution is chloroformic solution；
S2：The solution obtained in step S1 is poured into strip mould, aseptically so that solution evaporation film forming,
Filament of the aperture extrusion molding film production into 0.2mm will be used；
S3：By the filament thermoset forming in step S2, the temperature of thermoset forming is 40 degrees Celsius, according to inserting human body pipe in advance
The form of chamber prepares biological absorbable macromolecule nerve conduit stent.
Embodiment 3
The preparation method of the biological absorbable macromolecule nerve conduit stent comprises the following steps：
S1：The PLLA and molar content that the poly epsilon caprolactone lactone for being 40% by molar content, molar content are 40% be
20% polyhydroxyalkanoate is added in organic solution, stirring so that poly epsilon caprolactone lactone and PLLA fully dissolve, and have
Machine solution is chloroformic solution；
S2：The solution obtained in step S1 is poured into strip mould, aseptically so that solution evaporation film forming,
Filament of the aperture extrusion molding film production into 0.5mm will be used；
S3：By the filament thermoset forming in step S2, the temperature of thermoset forming is 100 degrees Celsius, according to inserting human body in advance
The form of tube chamber prepares biological absorbable macromolecule nerve conduit stent.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of biological absorbable macromolecule nerve conduit stent, it is characterised in that：The biological absorbable macromolecule nerve trachea
The structure of support is tubular structure, and the internal diameter of the tubular structure is 1.2-4.8mm, and the external diameter of the tubular structure is 1.5-
5.3mm, the aperture of the inner layer tube wall of the tubular structure is 0.3-10 μm, and outer layer aperture is 20-100 μm, and the biology can be inhaled
Receive macromolecule nerve conduit stent constituent be：Poly epsilon caprolactone lactone, PLLA and polyhydroxyalkanoate.
2. a kind of biological absorbable macromolecule nerve conduit stent according to claim 1, it is characterised in that：The poly- ε
The molar content of caprolactone is 30%-45%, and the molar content of the PLLA is 30%-45%, the poly- hydroxyl fat
The molar content of fat acid esters is 10%-40%.
3. a kind of preparation method of biological absorbable macromolecule nerve conduit stent, it is characterised in that：The biological absorbable high score
The preparation method of sub- nerve conduit stent comprises the following steps：
S1：PLLA that the poly epsilon caprolactone lactone for being 30%-45% by molar content, molar content are 30%-45% and mole
Content is added in organic solution for 10%-40% polyhydroxyalkanoate, stirring so that poly epsilon caprolactone lactone and PLLA
Fully dissolving；
S2：The solution obtained in step S1 is poured into strip mould, aseptically so that solution evaporation film forming, by film
It is fabricated to 0.2-0.5mm filament；
S3：By the filament thermoset forming in step S2, biological absorbable high score is prepared according to the form for inserting body lumen in advance
Sub- nerve conduit stent.
4. a kind of preparation method of biological absorbable macromolecule nerve conduit stent according to claim 3, its feature exists
In：Organic solution in the step S1 is chloroformic solution.
5. a kind of preparation method of biological absorbable macromolecule nerve conduit stent according to claim 3, its feature exists
In：The preparation method of filament in the step S2 is aperture extrusion molding.
6. a kind of preparation method of biological absorbable macromolecule nerve conduit stent according to claim 3, its feature exists
In：The temperature of thermoset forming is 40-100 degrees Celsius in the step S3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710609700.4A CN107261217A (en) | 2017-07-25 | 2017-07-25 | A kind of biological absorbable macromolecule nerve conduit stent and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710609700.4A CN107261217A (en) | 2017-07-25 | 2017-07-25 | A kind of biological absorbable macromolecule nerve conduit stent and preparation method |
Publications (1)
| Publication Number | Publication Date |
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| CN107261217A true CN107261217A (en) | 2017-10-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710609700.4A Pending CN107261217A (en) | 2017-07-25 | 2017-07-25 | A kind of biological absorbable macromolecule nerve conduit stent and preparation method |
Country Status (1)
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| CN (1) | CN107261217A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005068533A1 (en) * | 2004-01-15 | 2005-07-28 | Innocore Technologies B.V. | Boigradable multi-block co-polymers |
| CN101474423A (en) * | 2008-10-24 | 2009-07-08 | 清华大学 | Nerve conduit stent and preparation method thereof |
| CN103169546A (en) * | 2011-12-22 | 2013-06-26 | 上海纳米技术及应用国家工程研究中心有限公司 | Biologic absorbable macromolecule nerve conduit stent and manufacturing method thereof |
-
2017
- 2017-07-25 CN CN201710609700.4A patent/CN107261217A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005068533A1 (en) * | 2004-01-15 | 2005-07-28 | Innocore Technologies B.V. | Boigradable multi-block co-polymers |
| CN101474423A (en) * | 2008-10-24 | 2009-07-08 | 清华大学 | Nerve conduit stent and preparation method thereof |
| CN103169546A (en) * | 2011-12-22 | 2013-06-26 | 上海纳米技术及应用国家工程研究中心有限公司 | Biologic absorbable macromolecule nerve conduit stent and manufacturing method thereof |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171020 |
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| RJ01 | Rejection of invention patent application after publication |