CN107261044A - It is a kind of to treat pharmaceutical composition of pneumonia and preparation method thereof - Google Patents

It is a kind of to treat pharmaceutical composition of pneumonia and preparation method thereof Download PDF

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Publication number
CN107261044A
CN107261044A CN201710180723.8A CN201710180723A CN107261044A CN 107261044 A CN107261044 A CN 107261044A CN 201710180723 A CN201710180723 A CN 201710180723A CN 107261044 A CN107261044 A CN 107261044A
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parts
pharmaceutical composition
herb
standby
radix
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唐炳俭
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The present invention relates to a kind of pharmaceutical composition for treating pneumonia and preparation method thereof, the pharmaceutical composition is made up of the medicine of following parts by weight：Ke vine, Common St.Paulswort Herbs, rice bud, Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae, are made up of techniques such as water extractions；Confirm that pharmaceutical composition assay of the present invention is high by assay experiment；With the effect such as anti-inflammatory, sterilization；Without obvious toxic reaction under this experiment condition.

Description

It is a kind of to treat pharmaceutical composition of pneumonia and preparation method thereof
Technical field
The present invention relates to field of medicine invention, and in particular to a kind of to treat pharmaceutical composition of pneumonia and preparation method thereof.
Background technology
Pneumonia refers to the inflammation of last air flue eventually, alveolar and interstitial lung, can be immunized and damaged by disease microorganisms, chemical factors Wound, allergy and drug-induced, bacterial pneumonia is most common pneumonia, is also one of most common infectious diseases, daily institute The pneumonia said is primarily referred to as pneumonia caused by bacterial infection, and this pneumonia is also most common one kind, and most onsets are hurried, often Suffer from cold drench with rain, the inducement such as tired, virus infection, have the infection of the upper respiratory tract before about 1/3 illness.Course of disease 7-10 days.Major Clinical Show as：Cough, expectoration, pectoralgia, shiver with cold, hyperpyrexia, expiratory dyspnea.Anti-infective therapy is the main link of pneumonia treatment, The medicine for the treatment of pneumonia has much at present, and in the majority with Western medicine, based on western medicine, but the side effect of these medicines is larger, and Drug effect is also unsatisfactory, and virus sweep rate is low, and recurrence rate is higher, and antiviral drugs can not thoroughly remove the template of virus replication, Virus is given to transcribe the condition of duplication again, virus easily morphs, and forms drug resistance.Traditional medicine although draw in theory Gu opinion is modern, manages out evidence, but dialectical complicated and changeable, one side of card, is pestered beyond endurance, type and folder differ, it is impossible to form unified Diagnostic criteria and fixed prescription, thus curative effect is difficult to affirm；With the passing of time some patient's condition often delay, and disease and evil spreads all over the whole body, main threads Hardly possible reason, some patients are with worn with age, usually purging to treat the excess syndrome and tonifying for the deficiency, and tuberculosis is more difficult to recovery from illness.Therefore a kind of good effect is researched and developed The medicine of Small side effects is that comparison is urgent.
The present inventor have developed a kind of new drug to solve the above problems.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating pneumonia.
It is a further object of the present invention to provide a kind of preparation method for the pharmaceutical composition for treating pneumonia.
The present invention provides a kind of pharmaceutical composition for treating pneumonia, the pharmaceutical composition by following parts by weight medicine system Into：12-36 parts of Ke vine 20-45 Fen, Common St.Paulswort Herbs, 15-38 parts of rice bud, 12-35 parts of Physochlaina macrophylla, 10-30 parts of herba aristolochiae, belladonna Careless 15-30 parts, 12-30 parts of hooker winghead root, 18-38 parts of the Bi roots of grass, 10-36 parts of Radix Gentianae Macrophyllae flower, 13-35 parts of Amomum cardamomum, Flos Radix Asteris 16-37 Part, 10-26 parts of Chinese Incarvilla Herb, 13-38 parts of radix glycyrrhizae.
It is preferred that, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Ke vine 23-42 Fen, pig 15-34 parts of Xian grass, 18-35 parts of rice bud, 15-32 parts of Physochlaina macrophylla, 12-28 parts of herba aristolochiae, 17-28 parts of belladonna (herb), hooker winghead root 15- 25 parts, 22-36 parts of the Bi roots of grass, 13-32 parts of Radix Gentianae Macrophyllae flower, 15-32 parts of Amomum cardamomum, 19-34 parts of Flos Radix Asteris, 12-24 parts of Chinese Incarvilla Herb, radix glycyrrhizae 17-35 parts.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Ke vine 27- 40 18-31 parts of Fen, Common St.Paulswort Herbs, 20-32 parts of rice bud, 17-30 parts of Physochlaina macrophylla, 15-25 parts of herba aristolochiae, 19-26 parts of belladonna (herb), the wing First 17-23 parts of grass, 25-32 parts of the Bi roots of grass, 17-30 parts of Radix Gentianae Macrophyllae flower, 18-30 parts of Amomum cardamomum, 22-32 parts of Flos Radix Asteris, Chinese Incarvilla Herb 15-22 Part, 20-32 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Ke vine 22-28 parts of 30-37 Fen, Common St.Paulswort Herbs, 23-28 parts of rice bud, 20-27 parts of Physochlaina macrophylla, 17-22 parts of herba aristolochiae, 21-24 parts of belladonna (herb), 19-21 parts of hooker winghead root, 27-30 parts of the Bi roots of grass, 20-27 parts of Radix Gentianae Macrophyllae flower, 20-27 parts of Amomum cardamomum, 25-29 parts of Flos Radix Asteris, Chinese Incarvilla Herb 17- 20 parts, 23-28 parts of radix glycyrrhizae.
Still more preferably, pharmaceutical composition of the present invention is made up of the medicine of following parts by weight：Ke vine 33 25 parts of Fen, Common St.Paulswort Herbs, 25 parts of rice bud, 24 parts of Physochlaina macrophylla, 20 parts of herba aristolochiae, 22 parts of belladonna (herb), 20 parts of hooker winghead root, 29 parts of the Bi roots of grass, 23 parts of Radix Gentianae Macrophyllae flower, 23 parts of Amomum cardamomum, 27 parts of Flos Radix Asteris, 19 parts of Chinese Incarvilla Herb, 25 parts of radix glycyrrhizae.
Pharmaceutical composition of the present invention also contains pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention be solid pharmaceutical preparation or liquid preparation, the solid pharmaceutical preparation be tablet, capsule, Granule or pill；The liquid preparation is oral liquid.
Pharmaceutical composition preparation method of the present invention comprises the following steps：Jiang Ke vine, Common St.Paulswort Herbs, rice bud, the Huashan Ginseng, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae, pulverize and sieve, with pharmacy Upper acceptable carrier or diluent are well mixed, and are prepared into preparation.
Pharmaceutical composition preparation method of the present invention comprises the following steps：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into the 5-9 times of water measured, decocted 0.5-3 hours, filtering, filtrate concentration, dry, crushing It is standby into fine powder；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the 10-16 times of water measured, it is heated to reflux 2-4 times, each 2-5 hours, filtering, merging filtrate, filtrate concentration dry, pulverize into Fine powder, it is standby；
5) by step 2), 3), 4) standby fine powder is well mixed, add pharmaceutically acceptable carrier or diluent be mixed Close uniform, preparation is made.
It is preferred that, pharmaceutical composition preparation method of the present invention comprises the following steps：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 7 times of water measured, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 13 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, add pharmaceutically acceptable carrier or diluent be mixed Close uniform, preparation is made.
The parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of amount refers to the weight ratio of medicinal material again.
The pharmaceutically acceptable carrier or diluent refer to the conventional pharmaceutical carrier of pharmaceutical field, selected from filler, One or more in adhesive, disintegrant, lubricant, surfactant or flavouring.
Wherein described filler is selected from starch, sucrose, lactose, mannitol, sorbierite, xylitol, microcrystalline cellulose or Portugal Grape sugar etc.；
Described adhesive is selected from cellulose derivative, alginates, gelatin or polyvinylpyrrolidone etc.；
It is fine that the disintegrant is selected from microcrystalline cellulose, sodium carboxymethyl starch, polyvinylpyrrolidone, low substituted hydroxy-propyl Dimension element or Ac-Di-Sol；
The lubricant is selected from stearic acid, polyethylene glycol, calcium carbonate, sodium acid carbonate, silica, talcum powder or tristearin Sour magnesium；
The surfactant is selected from neopelex, stearic acid, Pluronic F68, fat Sorb is smooth or polysorbate (tween) etc. for fat acid；
The flavouring is selected from Aspartame, Sucralose or saccharin sodium.
The pharmaceutical composition for the treatment pneumonia that the present invention is provided has advantages below：
1st, confirm that pharmaceutical composition of the present invention imitates component content and determines high by assay experiment, containing biology Alkali is above standard value 0.25% in terms of hyoscyamine (C17H23NO3).
2nd, by pharmacodynamics test pharmaceutical composition of the present invention to A type and/or influenza B virus, with significantly killing Go out or inhibitory action, and with the effect such as anti-inflammatory, sterilization.
3rd, pharmaceutical composition of the invention is by acute toxicity test, and long term toxicity test result is shown：In this experiment bar Without obvious toxic reaction under part.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription：Ke vine 20g, Common St.Paulswort Herbs 12g, rice bud 15g, Physochlaina macrophylla 12g, herba aristolochiae 10g, belladonna (herb) 15g, the wing are first Careless 12g, Bi roots of grass 18g, Radix Gentianae Macrophyllae flower 10g, Amomum cardamomum 13g, Flos Radix Asteris 16g, Chinese Incarvilla Herb 10g, radix glycyrrhizae 13g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 5 times of water measured, decocted 0.5 hour, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 10 times of amounts, it is heated to reflux 2 times, 2 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/7, Load capsule, capsule is made.
Embodiment 2
Prescription：Ke vine 45g, Common St.Paulswort Herbs 36g, rice bud 38g, Physochlaina macrophylla 35g, herba aristolochiae 30g, belladonna (herb) 30g, the wing are first Careless 30g, Bi roots of grass 38g, Radix Gentianae Macrophyllae flower 36g, Amomum cardamomum 35g, Flos Radix Asteris 37g, Chinese Incarvilla Herb 26g, radix glycyrrhizae 38g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 9 times of water measured, decocted 3 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 16 times of amounts, it is heated to reflux 4 times, 5 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/7, Load capsule, capsule is made.
Embodiment 3
Prescription：Ke vine 23g, Common St.Paulswort Herbs 15g, rice bud 18g, Physochlaina macrophylla 15g, herba aristolochiae 12g, belladonna (herb) 17g, the wing are first Careless 15g, Bi roots of grass 22g, Radix Gentianae Macrophyllae flower 13g, Amomum cardamomum 15g, Flos Radix Asteris 19g, Chinese Incarvilla Herb 12g, radix glycyrrhizae 17g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 6 times of water measured, decocted 1 hour, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 12 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/5, Dry, tabletting produces the tablet of the application.
Embodiment 4
Prescription：Ke vine 42g, Common St.Paulswort Herbs 34g, rice bud 35g, Physochlaina macrophylla 32g, herba aristolochiae 28g, belladonna (herb) 28g, the wing are first Careless 25g, Bi roots of grass 36g, Radix Gentianae Macrophyllae flower 32g, Amomum cardamomum 32g, Flos Radix Asteris 34g, Chinese Incarvilla Herb 24g, radix glycyrrhizae 35g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 8 times of water measured, decocted 2 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 14 times of amounts, it is heated to reflux 3 times, 4 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/5, Dry, tabletting produces the tablet of the application.
Embodiment 5
Prescription：Ke vine 27g, Common St.Paulswort Herbs 18g, rice bud 20g, Physochlaina macrophylla 17g, herba aristolochiae 15g, belladonna (herb) 19g, the wing are first Careless 17g, Bi roots of grass 25g, Radix Gentianae Macrophyllae flower 17g, Amomum cardamomum 18g, Flos Radix Asteris 22g, Chinese Incarvilla Herb 15g, radix glycyrrhizae 20g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into the 5-9 times of water measured, decocted 0.5-3 hours, filtering, filtrate concentration, dry, crushing It is standby into fine powder；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the 10-16 times of water measured, it is heated to reflux 2-4 times, each 2-5 hours, filtering, merging filtrate, filtrate concentration dry, pulverize into Fine powder, it is standby；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/8, Mix, pelletize, dry, whole grain obtains the granule of the application.
Embodiment 6
Prescription：Ke vine 40g, Common St.Paulswort Herbs 31g, rice bud 32g, Physochlaina macrophylla 30g, herba aristolochiae 25g, belladonna (herb) 26g, the wing are first Careless 23g, Bi roots of grass 32g, Radix Gentianae Macrophyllae flower 30g, Amomum cardamomum 30g, Flos Radix Asteris 32g, Chinese Incarvilla Herb 22g, radix glycyrrhizae 32g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 7 times of water measured, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 13 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/8, Mix, pelletize, dry, whole grain obtains the granule of the application.
Embodiment 7
Prescription：Ke vine 30g, Common St.Paulswort Herbs 22g, rice bud 23g, Physochlaina macrophylla 20g, herba aristolochiae 17g, belladonna (herb) 21g, the wing are first Careless 19g, Bi roots of grass 27g, Radix Gentianae Macrophyllae flower 20g, Amomum cardamomum 20g, Flos Radix Asteris 25g, Chinese Incarvilla Herb 17g, radix glycyrrhizae 23g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 7 times of water measured, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 13 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/8, Mix, pelletize, dry, whole grain obtains the granule of the application.
Embodiment 8
Prescription：Ke vine 37g, Common St.Paulswort Herbs 28g, rice bud 28g, Physochlaina macrophylla 27g, herba aristolochiae 22g, belladonna (herb) 24g, the wing are first Careless 21g, Bi roots of grass 30g, Radix Gentianae Macrophyllae flower 27g, Amomum cardamomum 27g, Flos Radix Asteris 29g, Chinese Incarvilla Herb 20g, radix glycyrrhizae 28g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 7 times of water measured, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 13 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/8, Mix, pelletize, dry, whole grain obtains the granule of the application.
Embodiment 9
Prescription：Ke vine 33g, Common St.Paulswort Herbs 25g, rice bud 25g, Physochlaina macrophylla 24g, herba aristolochiae 20g, belladonna (herb) 22g, the wing are first Careless 20g, Bi roots of grass 29g, Radix Gentianae Macrophyllae flower 23g, Amomum cardamomum 23g, Flos Radix Asteris 27g, Chinese Incarvilla Herb 19g, radix glycyrrhizae 25g.
Preparation method：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into 7 times of water measured, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) by Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae Plus the water of 13 times of amounts, it is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby With；
5) by step 2), 3), 4) standby fine powder is well mixed, and adds the starch for accounting for well mixed fine powder weight 1/8, Mix, pelletize, dry, whole grain obtains the granule of the application.
The 1-9 of the embodiment of the present invention of embodiment 10 assay results in terms of hyoscyamine (C17H23NO3) containing alkaloid
Content assaying method takes the middle powder about 10g of this product, accurately weighed, puts in apparatus,Soxhlet's, plus the dense ammonia of ethanol 10ml Test solution 8ml and ether 20ml mixed liquor is appropriate, stands 12 hours, is heated to reflux with ether 70ml 3 hours, to biological alkali carries To the greatest extent, extract solution is put and most of ether is boiled off in water-bath, in dislocation separatory funnel, is shaken by several times with 0.5mol/L sulfuric acid titrating solution Extract, each 10ml, use up to biological alkali carries, merge acid solution, shaken, each 10ml is colourless to chloroform layer, closed by several times with chloroform And chloroform solution, shaken and extracted with 0.5mol/L sulfuric acid titrating solutions 10ml, discard chloroform, the acid solution obtained twice before and after merging, Filtration, filter is washed with 0.5mol/L sulfuric acid titrating solutions, merges washing lotion and filtrate, plus excessive strong ammonia solution makes in alkalescence, fast Speed with chloroform, extract by several times by shaking, is use up to biological alkali carries.Such as occur emulsion, ethanol can be added few drops, the chloroform obtained every time Liquid is washed with same water 10ml, discards washing lotion, is merged chloroform solution, is put and be evaporated in water-bath, plus ethanol 3ml, is evaporated, and 80 DEG C of dryings 2 hours, residue chlorination imitates 2ml, if necessary, and low-grade fever makes solution, precision plus sulfuric acid titrating solution (0.01mol/L) 20ml, puts and is heated in water-bath, remove chloroform, let cool to room temperature, and the red indicator solution 1~2 of methylate drips, and uses sodium hydroxide titration liquid (0.02mol/L) is titrated, and is produced.The C17H23NO3 of sulfuric acid titrating solution (0.01mol/L) equivalent to 5.788mg per 1ml.
This product is calculated by dry product, containing alkaloid in terms of hyoscyamine (C17H23NO3), must not be less than 0.25%.
Assay result
Sample Measurement result (is calculated, containing alkaloid in terms of hyoscyamine (C17H23NO3)) by dry product
Embodiment 1 0.35%
Embodiment 2 0.36%
Embodiment 3 0.31%
Embodiment 4 0.34%
Embodiment 5 0.35%
Embodiment 6 0.33%
Embodiment 7 0.38%
Embodiment 8 0.36%
Embodiment 9 0.34%
As a result, 1-9 of embodiment of the present invention pharmaceutical compositions are above mark containing alkaloid in terms of hyoscyamine (C17H23NO3) Quasi- value 0.25%, it is seen that effective component content of the present invention is high.
Drug effect and toxicological test that the pharmaceutical composition for the treatment of pneumonia of the herein below to provide above-described embodiment is carried out Research：
1st, experiment material
(1) medicine：Pharmaceutical composition (high dose group, middle dose group, the low dosage of the experiment embodiment of the present invention 1 used Group)；A Qing mycins；Aspirin；Cold granules.
(2) Strain：Influenza A virus A/PR/8/34, the anti-98-76 in influenza B virus B/ capital.
(3) bacterial strain：Reference culture：Staphylococcus aureus (25923), Escherichia coli (25922), table staphylococcus, Middle staphylococcus, dissolving staphylococcal bacteria, very Bacillus alcaligenes, change bacillus, acinetobacter calcoaceticus, beta streptococcus, staphylococcus aureus (standard), Escherichia coli (standard), Hough Leah bacillus, proteus, the abnormal bacillus of plate, citric acid enterobacteria, Human fetal cardiomyocytes And Diplococcus pneumopniae, Clinical isolation.
(4) animal：KM kind small white mouses, 18~22g of body weight；SD rats, 170~210g；Rabbit, 2.1~2.3kg, male and female Half and half.
(5) reagent：Dimethylbenzene；Glacial acetic acid；Endotoxin；Dry ferment.
2nd, test method and result
Tested respectively according to content as described below.Quantitative response data represent with mean+SD, qualitative response Data are expressed as a percentage, and t inspections, X is respectively adopted2Examine and carry out statistical procedures.
(1) antivirus action
1. to the protective effect of A type or influenza B virus infecting mouse
KM kinds mouse 120 is taken, 9 groups, every group 20 are randomly divided into.60min after first administration, in addition to Normal group, Remaining each group mouse is given under ether light anaesthesia state with the A type of hemagglutination test more than 640 or influenza B virus allantoic fluid Mouse collunarium infects, per the μ l of mouse 30 (20 LD50Challenging dose).Dosage gastric infusion 20ml/kg of each group as shown in table 1, daily 1 time, continuous 5 days, Normal group, the isometric distilled water of model group gavage.Day by day the hair after zoogenetic infection and administration is observed Disease and death condition, record the death toll in 14 days.The results detailed in Table 1.
Protective effect of the table 1 to A type or influenza B virus infecting mouse
Note：Compared with model group：* p ＜ 0.05, * * p ＜ 0.01, * * * p ＜ 0.001.
As it can be seen from table 1 three dosage of pharmaceutical composition of the present invention can improve A type and B-mode stream to some extent The time-to-live of the survival rate of Influenza Virus infecting mouse, extension A type and influenza B virus infecting mouse, with model group ratio Compared with having conspicuousness or pole significant difference (p ＜ 0.05 or p ＜ 0.01).
3. brief summary
Table 1 test result indicates that, pharmaceutical composition of the present invention has obvious antivirus action.
(2) antibacterial action
1. to the protective effect of infection of staphylococcus aureus mouse
KM kinds mouse 120 is taken, 6 groups, every group 20 are randomly divided into.Dosage gastric infusion of each group as shown in table 2 26ml/kg, 1 time a day, continuous 5 days, Normal group, the isometric distilled water of model group gavage.60min after administration in 3rd day, In addition to Normal group, (bacteria containing amount is 1 LD to intraperitoneal injection staphylococcus aureus nutrient solution50) 0.5ml/ is only.Observe animal Morbidity and death condition after infection and administration, record the death toll in 7 days.The results detailed in Table 2.
Protective effect of the table 2 to infection of staphylococcus aureus mouse
Note：Compared with model group：* p ＜ 0.05, * * p ＜ 0.01, * * * p ＜ 0.001.
From table 3 it can be seen that three dosage of medicine of the present invention can improve infection of staphylococcus aureus to some extent The survival rate of mouse, but it is not statistically significant, extend the time-to-live of infection of staphylococcus aureus mouse, wherein, embodiment The effect of 1 high dose substantially, is compared with model group, there is significant difference (p ＜ 0.05).
2. brief summary
Table 2 test result indicates that, pharmaceutical composition of the present invention has certain antibacterial action.
(3) antiinflammatory action
1. Dichlorodiphenyl Acetate causes the increased influence of mouse capillary permeability
KM kinds mouse 50 is taken, 5 groups, every group 10 are randomly divided into.Dosage gastric infusion 20ml/ of each group as shown in table 4 Kg, 1 time a day, for three days on end, the isometric distilled water of model group gavage.45min after last dose, tail vein injection 0.5% she After train of thought indigo plant normal saline solution 0.1ml/10g, 0.6% acetic acid 0.1ml/10g, 20min of retinue intraperitoneal injection, mouse is put to death, Abdominal cavity is opened, abdominal cavity is rinsed repeatedly with 5ml physiological saline three times, cleaning solution, 1000rpm centrifugation 5min, ultraviolet spectrometry light is collected Trap (OD values) is determined at degree meter 590nm.The results detailed in Table 3.
The Dichlorodiphenyl Acetate of table 3 causes the increased influence of mouse capillary permeability
Group Dosage (g/kg) Trap (OD values)
Model 0.212±0.050
Aspirin 0.6 0.131±0.041**
The high dose of embodiment 1 12 0.132±0.039**
The middle dosage of embodiment 1 6 0.139±0.071*
The low dosage of embodiment 1 3 0.172±0.0791
Note：Compared with model group：* p ＜ 0.05, * * p ＜ 0.01, * * * p ＜ 0.001.
From table 3 it can be seen that three dosage of medicine of the present invention can reduce mouse capillary caused by acetic acid to some extent Vasopermeability increase, the wherein effect of the middle and high dosage of embodiment 1 substantially, are compared with model group, have conspicuousness or extremely notable Sex differernce (p ＜ 0.05 or p ＜ 0.01).
2. paraxylene causes the antiinflammatory action of mice ear
KM kinds mouse 50 is taken, 5 groups, every group 10 are randomly divided into.Dosage gastric infusion 20ml/ of each group as shown in table 4 Kg, 1 time a day, for three days on end, the isometric distilled water of model group gavage.45min after last dose, mouse right ear two sides applies diformazan Only, left ear is not applied benzene 0.05ml/.Mouse is put to death after 45min, disk is laid in ears same area respectively, weighs, calculates swollen Expansibility (=auris dextra weight-left ear weight), swelling inhibiting rate [=(model group swelling average-administration group swelling average)/ Model group swelling average × 100%].The results detailed in Table 4.
The paraxylene of table 4 causes the antiinflammatory action of mice ear
Group Dosage (g/kg) Auricle swelling degree (mg) Swelling inhibiting rate (%)
Model - 0.0191±0.0051 -
Aspirin 0.4 0.0062±0.0032*** 67.54
The high dose of embodiment 1 8 0.0071±0.0052** 62.83
The middle dosage of embodiment 1 4 0.0096±0.0051* 49.74
The low dosage of embodiment 1 2 0.0119±0.0041 37.69
Note：Compared with model group：* p ＜ 0.05, * * p ＜ 0.01, * * * p ＜ 0.001.
From table 4, it can be seen that three dosage of medicine of the present invention can reduce mouse ear caused by dimethylbenzene to some extent Swelling, wherein, the effect of the middle and high dosage of embodiment 1 substantially, is compared with model group, there is conspicuousness or pole significant difference (p ＜ 0.05 or p ＜ 0.01).
3. brief summary table 4 test result indicates that, pharmaceutical composition of the present invention to chemical substance stimulate caused by inflammation it is anti- There should be certain antagonism.
(4) safety analysis and evaluation
This product is shown by acute toxicity test, long term toxicity test result：Without obvious toxicity under this experiment condition Reaction.
Conclusion (of pressure testing)
Confirm that pharmaceutical composition assay of the present invention is high, to A type by assay and pharmacological testing And/or influenza B virus, act on significant killing or inhibiting effect, and with anti-inflammatory, sterilization etc..With it is existing commercially available Preparation is compared, and present invention effect is obvious, rapid-action, has no toxic side effect.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment State, but on the basis of the present invention, some modifications can be made to it or are improved, this be to those skilled in the art it is aobvious and It is clear to.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to application claims The scope of protection.

Claims (10)

1. a kind of pharmaceutical composition for treating pneumonia, it is characterised in that the pharmaceutical composition is made up of the medicine of following parts by weight： 12-36 parts of Ke vine 20-45 Fen, Common St.Paulswort Herbs, 15-38 parts of rice bud, 12-35 parts of Physochlaina macrophylla, 10-30 parts of herba aristolochiae, belladonna (herb) 15- 30 parts, 12-30 parts of hooker winghead root, 18-38 parts of the Bi roots of grass, 10-36 parts of Radix Gentianae Macrophyllae flower, 13-35 parts of Amomum cardamomum, 16-37 parts of Flos Radix Asteris, Chinese Incarvilla Herb 10-26 parts, 13-38 parts of radix glycyrrhizae.
2. pharmaceutical composition according to claim 1, it is characterised in that the pharmaceutical composition by following parts by weight medicine It is made：15-34 parts of Ke vine 23-42 Fen, Common St.Paulswort Herbs, 18-35 parts of rice bud, 15-32 parts of Physochlaina macrophylla, 12-28 parts of herba aristolochiae, belladonna Careless 17-28 parts, 15-25 parts of hooker winghead root, 22-36 parts of the Bi roots of grass, 13-32 parts of Radix Gentianae Macrophyllae flower, 15-32 parts of Amomum cardamomum, Flos Radix Asteris 19-34 Part, 12-24 parts of Chinese Incarvilla Herb, 17-35 parts of radix glycyrrhizae.
3. pharmaceutical composition according to claim 2, it is characterised in that the pharmaceutical composition by following parts by weight medicine It is made：18-31 parts of Ke vine 27-40 Fen, Common St.Paulswort Herbs, 20-32 parts of rice bud, 17-30 parts of Physochlaina macrophylla, 15-25 parts of herba aristolochiae, belladonna Careless 19-26 parts, 17-23 parts of hooker winghead root, 25-32 parts of the Bi roots of grass, 17-30 parts of Radix Gentianae Macrophyllae flower, 18-30 parts of Amomum cardamomum, Flos Radix Asteris 22-32 Part, 15-22 parts of Chinese Incarvilla Herb, 20-32 parts of radix glycyrrhizae.
4. pharmaceutical composition according to claim 3, it is characterised in that the pharmaceutical composition by following parts by weight medicine It is made：22-28 parts of Ke vine 30-37 Fen, Common St.Paulswort Herbs, 23-28 parts of rice bud, 20-27 parts of Physochlaina macrophylla, 17-22 parts of herba aristolochiae, belladonna Careless 21-24 parts, 19-21 parts of hooker winghead root, 27-30 parts of the Bi roots of grass, 20-27 parts of Radix Gentianae Macrophyllae flower, 20-27 parts of Amomum cardamomum, Flos Radix Asteris 25-29 Part, 17-20 parts of Chinese Incarvilla Herb, 23-28 parts of radix glycyrrhizae.
5. pharmaceutical composition according to claim 4, it is characterised in that the pharmaceutical composition by following parts by weight medicine It is made：25 parts of the Fen, Common St.Paulswort Herbs of Ke vine 33,25 parts of rice bud, 24 parts of Physochlaina macrophylla, 20 parts of herba aristolochiae, 22 parts of belladonna (herb), hooker winghead root 20 Part, 29 parts of the Bi roots of grass, 23 parts of Radix Gentianae Macrophyllae flower, 23 parts of Amomum cardamomum, 27 parts of Flos Radix Asteris, 19 parts of Chinese Incarvilla Herb, 25 parts of radix glycyrrhizae.
6. the pharmaceutical composition according to claim any one of 1-5, it is characterised in that the pharmaceutical composition also contains pharmacy Upper acceptable carrier or diluent.
7. pharmaceutical composition according to claim 6, it is characterised in that described pharmaceutical composition is solid pharmaceutical preparation or liquid Preparation, the solid pharmaceutical preparation is tablet, capsule, granule or pill；The liquid preparation is oral liquid.
8. a kind of method for preparing the pharmaceutical composition described in claim any one of 1-5, it is characterised in that this method include with Lower step：Jiang Ke vine, Common St.Paulswort Herbs, rice bud, Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, purple Aster, Chinese Incarvilla Herb, radix glycyrrhizae, pulverize and sieve, and are well mixed with pharmaceutically acceptable carrier or diluent, are prepared into preparation.
9. a kind of method for preparing any one of claim 1-5 described pharmaceutical composition, it is characterised in that this method includes following Step：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added into the 5-9 times of water measured, decocted 0.5-3 hours, filtering, filtrate concentrates, dries, is ground into carefully Powder, it is standby；
4) Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae are added into 10- The water of 16 times of amounts, is heated to reflux 2-4 times, each 2-5 hours, filtering, merging filtrate, filtrate concentration, dry, pulverize into fine powder, It is standby；
5) by step 2), 3), 4) standby fine powder is well mixed, add pharmaceutically acceptable carrier or diluent mixing be equal It is even, preparation is made.
10. the preparation method of pharmaceutical composition according to claim 9, it is characterised in that this method comprises the following steps：
1) parts by weight medicine is weighed standby；
2) rice bud is broken into fine powder, it is standby；
3) Ke vine, Common St.Paulswort Herbs are added to the water of 7 times of amounts, decocted 1.5 hours, filtering, filtrate concentrates, dries, is ground into fine powder, standby With；
4) Physochlaina macrophylla, herba aristolochiae, belladonna (herb), hooker winghead root, the Bi roots of grass, Radix Gentianae Macrophyllae flower, Amomum cardamomum, Flos Radix Asteris, Chinese Incarvilla Herb, radix glycyrrhizae are added 13 times The water of amount, is heated to reflux 3 times, 3 hours every time, filtering, merging filtrate, filtrate concentration dry, pulverize into fine powder, standby；
5) by step 2), 3), 4) standby fine powder is well mixed, add pharmaceutically acceptable carrier or diluent mixing be equal It is even, preparation is made.
CN201710180723.8A 2017-03-18 2017-03-18 It is a kind of to treat pharmaceutical composition of pneumonia and preparation method thereof Pending CN107261044A (en)

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JP2011225505A (en) * 2010-04-16 2011-11-10 Kracie Seiyaku Kk Chinese herb/crude drug product with pruni cortex for skin disease treatment
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