CN107255708A - Detect frozen blood device and its system and its detection method - Google Patents
Detect frozen blood device and its system and its detection method Download PDFInfo
- Publication number
- CN107255708A CN107255708A CN201710396751.3A CN201710396751A CN107255708A CN 107255708 A CN107255708 A CN 107255708A CN 201710396751 A CN201710396751 A CN 201710396751A CN 107255708 A CN107255708 A CN 107255708A
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- CN
- China
- Prior art keywords
- frozen blood
- blood
- cell
- shearing force
- various kinds
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
Abstract
Frozen blood device is detected the invention provides one kind, is had the feature that, including：Test section, it is arranged on slicer, content for detecting various kinds of cell in frozen blood, with inductive pick-up and signal amplifier, inductive pick-up cuts frozen blood, the shearing force of various kinds of cell in sensing frozen blood simultaneously generates corresponding shearing force signal, and signal amplifier is used to amplify shearing force signal；And Treatment Analysis portion, it is connected with test section, the shearing force signal after amplifying for reception and the content for being handled it and being analyzed the various kinds of cell obtained in frozen blood.The detection frozen blood device is directly monitored, relative error is smaller using directly being detected to frozen blood in the case where blood is lyophilized in solid-state by mechanical property.The method being combined compared to physical chemistry, this method is more simple and convenient.
Description
Technical field
The present invention relates to frozen blood detection field, and in particular to one kind detection frozen blood device and its system and its
Detection method.
Background technology
Instantly, more and more hospitals focus on the preservation and big data information extraction of organ-tissue, but as time goes by,
The biological information of some organ-tissues will disappear, therewith, it is contemplated that method be freezing, can with preservation tissue, blood,
Organ etc..At this stage, it is by ELISA, anti-electric-resistivity method after thawing for the blood testing after freezing and refrigeration
Analyzed Deng Typical physical or chemical method.
Most important several are red blood cell, leucocyte and blood platelet in the routine inspection of general blood.The detection of leucocyte
It is electrical impedance method.Electrical impedance method blood count principle is due to that resistance increases in container induction zone, causes transient voltage to change
Pulse signal is formed, pulse signal is higher, and cell volume is bigger, and number of pulses is more, and cell quantity is more, it follows that blood
Middle haemocyte quantity and bulking value.The Cleaning Principle of leucocyte is exactly, by the processing of blood solvent, dehydration, to be calculated according to electrical impedance method
The percentage of the cell subset of different volumes, and the absolute value of each cell subset is calculated, show the volume distributed median Nogata of leucocyte
Figure.Red blood cell is usually microscopic method by hand.In isotonic diluent liquid by hemodilution certain multiple, count under the microscope.
Red blood cell, leucocyte and the blood platelet in detection blood can also be sent out according to light scattering.In a word, these methods are required for after freezing
Blood thaw, detected again by physics and chemically combined method again.Thawing can be to the cellular damage in the blood after freezing
And detection method general procedure is more complicated.
The content of the invention
The present invention is carried out to solve the above problems, it is therefore intended that detection frozen blood device and its system and
Its detection method.
Frozen blood device is detected the invention provides one kind, is had the feature that, including：Test section, is arranged on and cuts
On piece machine, the content for detecting various kinds of cell in frozen blood, with inductive pick-up and signal amplifier, sensing sensing
Device cuts the shearing force of the various kinds of cell in frozen blood, sensing frozen blood and generates corresponding shearing force signal, signal
Amplifier is used to amplify shearing force signal；And Treatment Analysis portion, it is connected with test section, for receiving the shearing force letter after amplification
Number and handled it and analyzed the content of the various kinds of cell obtained in frozen blood.
In the detection frozen blood device that the present invention is provided, it can also have the feature that：Wherein, inductive pick-up
For piezoelectricity inductive pick-up.
In the detection frozen blood device that the present invention is provided, it can also have the feature that：Wherein, voltage inductance should be passed
It is additionally provided with sensor, the specific recognition material is used for the species for recognizing the various kinds of cell in frozen blood.
In the detection frozen blood device that the present invention is provided, it can also have the feature that：Wherein, processing unit is meter
Calculation machine or other smart machines.
Frozen blood system is detected the invention also discloses one kind, is had the feature that, including：Slicer, for putting
Put frozen blood to be detected；And detection frozen blood device, it is arranged on slicer, it is a variety of in frozen blood for detecting
The content of cell, wherein, detection frozen blood device is the detection frozen blood device of above-mentioned middle any one.
Have the feature that, comprise the following steps the invention also discloses a kind of method for detecting frozen blood：To cold
Freeze blood to be cut；The shearing force of various kinds of cell in frozen blood is received in cutting and corresponding shearing force signal is generated；
Shearing force signal is amplified；Handled the shearing force signal after amplification and analyzed the content for obtaining various kinds of cell.
The effect of invention and effect
Frozen blood device is detected according to offer involved in the present invention, the detection frozen blood device is using directly to cold
Freeze blood to be detected, be directly monitored in the case where blood is lyophilized in solid-state by mechanical property, relative error
It is smaller.The method being combined compared to physical chemistry, this method is more simple and convenient.In addition, existing sensing technology is non-
It is often ripe, specific recognition material is combined with inductive pick-up, indices in blood, institute point-device can be detected
Can be more accurate with testing result.
Brief description of the drawings
Fig. 1 is the structural representation of detection frozen blood system in embodiments of the invention；
Fig. 2 is the structural representation of detection frozen blood device in embodiments of the invention.
Embodiment
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, it is real below
Example combination accompanying drawing is applied to be specifically addressed present invention detection frozen blood device and its system and its detection method.
Detect that frozen blood system 100 includes slicer 10 and detection frozen blood device 20, the detection frozen blood
The content for the various kinds of cell that system is used in directly detection frozen blood.
Fig. 1 is the structural representation of detection frozen blood system in embodiments of the invention.
As shown in figure 1, slicer 10 includes being used to place frozen blood print platform 11 to be detected and for placing inspection
Survey the base 12 of frozen blood device.In the present embodiment, it is additionally provided with signal output device on base 12.
Fig. 2 is the structural representation of detection frozen blood device in embodiments of the invention.
As shown in Fig. 2 detection frozen blood device 20 is arranged on slicer 10, including test section 21 and Treatment Analysis
Portion's (not shown).
Test section 21 is set on base 12, for detecting frozen blood, including inductive pick-up 211, signal amplifier
212nd, specific recognition material layer 213 and electrode slice 214.
Inductive pick-up 211 is in blade-like, for cutting frozen blood, and sensing freezing while frozen blood is cut
The shearing force of various kinds of cell and corresponding shearing force signal is generated in blood.In the present embodiment, inductive pick-up 211 is piezoelectricity
Inductive pick-up.
Signal amplifier 212 is connected with inductive pick-up 211, for amplifying the shearing force signal of various cells and carrying out defeated
Go out.
Specific recognition material layer 213 is arranged on the place that the cutter head of inductive pick-up 211 and frozen blood are contacted, and is used for
Recognize the species of various kinds of cell in frozen blood.In the present embodiment, specific recognition material layer 213 can be single pure
The mixture of the either a variety of identification materials of thing, the species of various kinds of cell is red blood cell, leucocyte and blood platelet, actually should
During, thus it is possible to vary the species of specific recognition material layer 213, other organs or tissue are identified.
Electrode slice 214 is arranged at the bosom of the cutter head of inductive pick-up 211.
Treatment Analysis portion is connected with test section, for receiving the shearing force signal after amplification, and to the shearing force after amplification
Signal, which is handled and analyzed, obtains red blood cell in frozen blood, leucocyte and hematoblastic content.
The invention also discloses a kind of method for detecting frozen blood, comprise the following steps：
Frozen blood is cut.
The shearing force of various kinds of cell in frozen blood is received in cutting and corresponding shearing force signal is generated.
Shearing force signal is amplified.
Handled the shearing force signal after amplification and analyzed the content for obtaining various kinds of cell.
The operation principle of detection frozen blood system 100 is：When piezoelectricity inductive pick-up is cut to frozen blood
The shearing force signal of various kinds of cell in frozen blood is received simultaneously, and specific recognition material layer 213 is known to various kinds of cell
Not, various kinds of cell is obtained for red blood cell, leucocyte and blood platelet, and 212 pairs of shearing force signals of signal amplifier are amplified, and are led to
Cross electrode slice to be exported, the shearing force signal after the amplification that the signal output device in base 12 exports signal amplifier 212
Exported again, Treatment Analysis portion receives and handles shearing force signal, analysis obtain the red blood cell of frozen blood, leucocyte with
And hematoblastic content.
The effect of embodiment and effect
Offer detection frozen blood device in the present embodiment, the detection frozen blood device is using directly to freezing
Blood is detected, is directly monitored in the case where blood is lyophilized in solid-state by mechanical property, relative error compared with
It is small.The method being combined compared to physical chemistry, this method is more simple and convenient.In addition, existing sensing technology is very
Maturation, specific recognition material is combined with inductive pick-up, point-device can detect indices in blood, so
Testing result can be more accurate.
Furthermore it is possible to realize the detection to other organs or tissue by changing specific recognition material.
In addition, continuing to develop with technology, can also expand the examination scope of cell in frozen blood, blood is such as checked
Middle viscosity and blood glucose etc..
Above-mentioned embodiment is the preferred case of the present invention, is not intended to limit protection scope of the present invention.
Claims (6)
1. one kind detection frozen blood device, is arranged on slicer, it is characterised in that including：
Test section, is arranged on slicer, the content for detecting various kinds of cell in frozen blood, with inductive pick-up and
Signal amplifier, the inductive pick-up cuts the frozen blood, senses the shearing of the various kinds of cell in the frozen blood
Power simultaneously generates corresponding shearing force signal, and the signal amplifier is used to amplify the shearing force signal；And
Treatment Analysis portion, is connected with the test section, for receiving the shearing force signal after amplification and it being handled
And analyze the content of the various kinds of cell obtained in the frozen blood.
2. detection frozen blood device according to claim 1, it is characterised in that：
Wherein, the inductive pick-up is piezoelectricity inductive pick-up.
3. detection frozen blood device according to claim 2, it is characterised in that：
Wherein, it is additionally provided with the piezoelectricity inductive pick-up, the specific recognition material is used to recognize in the frozen blood
The various kinds of cell species.
4. detection frozen blood device according to claim 1, it is characterised in that：
Wherein, the processing unit is computer or other smart machines.
5. one kind detection frozen blood system, it is characterised in that including：
Slicer, for placing frozen blood to be detected；And
Frozen blood device is detected, is arranged on the slicer, the content for detecting the various kinds of cell in frozen blood,
Wherein, the detection frozen blood device is the detection frozen blood device described in any one in Claims 1 to 5.
6. one kind detection frozen blood method, it is characterised in that comprise the following steps：
Frozen blood is cut；
The shearing force of various kinds of cell in the frozen blood is received in cutting and generates corresponding shearing force signal；
The shearing force signal is amplified；
Handled the shearing force signal after amplification and analyzed the content for obtaining the various kinds of cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710396751.3A CN107255708A (en) | 2017-05-31 | 2017-05-31 | Detect frozen blood device and its system and its detection method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710396751.3A CN107255708A (en) | 2017-05-31 | 2017-05-31 | Detect frozen blood device and its system and its detection method |
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| Publication Number | Publication Date |
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| CN107255708A true CN107255708A (en) | 2017-10-17 |
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ID=60027499
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710396751.3A Pending CN107255708A (en) | 2017-05-31 | 2017-05-31 | Detect frozen blood device and its system and its detection method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050044971A1 (en) * | 2003-09-02 | 2005-03-03 | Harris Joel Steven | Motor driven sampling apparatus for material collection |
| CN200953002Y (en) * | 2006-10-09 | 2007-09-26 | 袁洪 | Dried blood sheet scanner |
| CN201222062Y (en) * | 2008-05-08 | 2009-04-15 | 德奥生物科技股份有限公司 | Biology sensitive test slice |
| US20110269166A1 (en) * | 2010-04-30 | 2011-11-03 | Ut-Battelle, Llc | Sealing surface sampling probe applied to blood spots and tissues |
| CN203025004U (en) * | 2013-01-15 | 2013-06-26 | 广州蓝勃生物科技有限公司 | Dried blood slice cutter |
-
2017
- 2017-05-31 CN CN201710396751.3A patent/CN107255708A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050044971A1 (en) * | 2003-09-02 | 2005-03-03 | Harris Joel Steven | Motor driven sampling apparatus for material collection |
| CN200953002Y (en) * | 2006-10-09 | 2007-09-26 | 袁洪 | Dried blood sheet scanner |
| CN201222062Y (en) * | 2008-05-08 | 2009-04-15 | 德奥生物科技股份有限公司 | Biology sensitive test slice |
| US20110269166A1 (en) * | 2010-04-30 | 2011-11-03 | Ut-Battelle, Llc | Sealing surface sampling probe applied to blood spots and tissues |
| CN203025004U (en) * | 2013-01-15 | 2013-06-26 | 广州蓝勃生物科技有限公司 | Dried blood slice cutter |
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Application publication date: 20171017 |