CN107242576A - The pregnant woman and wet nurse of a kind of instant are with nutritious supplementary pharmaceutical product and preparation method thereof - Google Patents

The pregnant woman and wet nurse of a kind of instant are with nutritious supplementary pharmaceutical product and preparation method thereof Download PDF

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Publication number
CN107242576A
CN107242576A CN201710437705.3A CN201710437705A CN107242576A CN 107242576 A CN107242576 A CN 107242576A CN 201710437705 A CN201710437705 A CN 201710437705A CN 107242576 A CN107242576 A CN 107242576A
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CN
China
Prior art keywords
nutrient
pregnant woman
nutritious supplementary
supplementary pharmaceutical
container
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CN201710437705.3A
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Chinese (zh)
Inventor
杨四成
张洁
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Beijing Maddie Sea Industry Co Ltd
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Beijing Maddie Sea Industry Co Ltd
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Priority to CN201710437705.3A priority Critical patent/CN107242576A/en
Publication of CN107242576A publication Critical patent/CN107242576A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
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    • B65D81/2069—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere
    • B65D81/2076—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient under vacuum or superatmospheric pressure, or in a special atmosphere, e.g. of inert gas in a special atmosphere in an at least partially rigid container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/70—Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for
    • B65D85/804—Disposable containers or packages with contents which are mixed, infused or dissolved in situ, i.e. without having been previously removed from the package
    • B65D85/816—Disposable containers or packages with contents which are mixed, infused or dissolved in situ, i.e. without having been previously removed from the package into which liquid is added and the resulting preparation is retained, e.g. cups preloaded with powder or dehydrated food
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    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

Nutritious supplementary pharmaceutical product is used the invention discloses a kind of pregnant woman of instant and wet nurse, it is characterised in that the container being made up of nutritious supplementary pharmaceutical and exotic material is constituted；The nutritious supplementary pharmaceutical is put into exotic material container, sealing container, and inert gas is filled with container；The nutritional supplement ingredients weight ratio is：18~35 parts of good protein, 1 10 parts of nutrient, 50 84 parts of auxiliary material, the product instant, safe ready absorbs more preferable, preparation method is simple, is adapted to industrialized production.

Description

The pregnant woman and wet nurse of a kind of instant are with nutritious supplementary pharmaceutical product and preparation method thereof
Technical field
The present invention relates to field of health care products, the more particularly to pregnant woman of instant and wet nurse's nutritious supplementary pharmaceutical.
Background technology
Existing pregnant woman and wet nurse milk powder is pregnant woman, the measure of women breast-feeding their children's improvement nutrition condition on the market, is used as meals Diversified part or extra supplement are eaten, target group's pregnancy period, nursing period is met to the additional demand of nutrient.Pregnant woman And wet nurse's milk powder belongs to modulation milk powder, GB19644 should be met《National food safety standard milk powder》Requirement, enterprise can basis GB14880《National food safety standard food enrichment uses standard》Requirement, voluntarily strengthen some battalion in the product Support element.The label of such product should meet GB7718《National food safety standard prepackaged food label general rule》And GB28050 《National food safety standard prepackaged food nutritional labeling general rule》Requirement.
The present invention relates to a kind of safe, instant pregnant woman and wet nurse's nutritional supplementation agent capsules and its corresponding preparation Method, is a kind of food for the purpose of supplementing protein and micronutrient, is a kind of highdensity nutrient supplement food, production Micronutrient content requirement is significantly higher than pregnant woman and the wet nurse's milk powder of reinforcing in product.The based food belongs to food for special foods Classification, can be that nutrient content is basis in pregnant woman and wet nurse's supplement good protein and lot of trace nutrient, its product 《DRIs 2013》, the diet nutrient intake data of combining target crowd etc. determine 's.The technical indicator of such product should meet GB 31601《National food safety standard-pregnant woman and wet nurse's nutrient supplement food》 Requirement, its label should meet GB13432《National food safety standard-pre-packaged food for special foods label》Requirement. Safety, instant pregnant woman and wet nurse's nutritional supplementation agent capsules provide a kind of protein and other needs for target group The compensation process of nutrient, can ensure pregnant woman and wet nurse as pregnant woman and conveniently, safely one of method of wet nurse's nutrition improvement Nutritional need and edible safety, it will played a role to the nutrition improvement of China pregnant woman and wet nurse.
The content of the invention
It is an object of the invention to provide a kind of good protein and lot of trace existed for China pregnant woman and wet nurse The nutrition correlative problems such as Nutrition intake deficiency and the food for special foods of a kind of instant produced and processed, addition Good protein and lot of trace nutrient (vitamin and mineral etc.), to meet pregnant women itself and cyotrophy Specific demand, meets the specific demand of postpartum women itself and infant nutrition, to pregnant woman and wet nurse's good protein and various The supplement of micronutrient will play very important effect, promote fetus or baby's normal development, prevention and reduction pregnancy period are simultaneously The generation for the problems such as sending out disease and low birth weight infant.Contribute to wet nurse's postpartum physical recovery and galactosis, promote neonate to be good for Kang Fayu.Another object of the present invention is to provide the pregnant woman of instant and the preparation method of wet nurse's nutritious supplementary pharmaceutical.
To achieve the above object, the present invention is achieved through the following technical solutions：
The pregnant woman and wet nurse of a kind of instant of the present invention use nutritious supplementary pharmaceutical product, it is characterised in that be by nutrition The container of replenishers and exotic material composition is constituted；The nutritious supplementary pharmaceutical is put into exotic material container, sealing container, Inert gas is filled with container；The nutritious supplementary pharmaceutical includes following weight parts composition：
Good protein
1-10 parts of nutrient,
35-84 parts of auxiliary material.
Further preferably, nutritious supplementary pharmaceutical of the present invention includes following weight percent composition：
25-30 parts of good protein,
2-5 parts of nutrient,
50-69 parts of auxiliary material.
In good protein of the present invention without fishy smell, ANFs should not be contained.
Good protein of the present invention should be in soyabean protein powder, soybean protein powder product, newborn class, dairy products One or more, preferred soyabean protein powder.
Nutrient of the present invention includes core nutrient (must have) and selective nutrient.Described core nutrition The composition of element see the table below 1：
The core nutrient of table 1
Core nutrient Pregnant woman uses (daily μ g) Wet nurse uses (daily μ g)
Vitamin A 230-700 400-1200
Vitamin D 3-10 3-10
Vitamin B12 1.2-4.8 1.3-5.2
Folic acid 140-400 130-400
Iron 9000-18000 7000-16000
The selective nutrient includes one or more of table 2.
The selective nutrient of table 2
Further preferably, the core nutrient preferred weight ratio is shown in Table 3：
The core nutrient preferred weight ratio of table 3
Core nutrient Pregnant woman uses (daily μ g) Wet nurse uses (daily μ g)
Vitamin A 400-600 800-1000
Vitamin D 6-8 8-10
Vitamin B12 3.6-4.0 4.0-5.0
Folic acid 300-400 300-400
Iron 15000-16000 14000-15000
Further preferably, the selective nutrient preferred weight ratio is shown in Table 4
The selective nutrient preferred weight ratio of table 4：
Selective nutrient Pregnant woman (daily μ g) Wet nurse (daily μ g)
Vitamin E (а-TE) 10000-12000 12000-15000
Vitamin K 50-70 60-80
Vitamin B1 2000-2500 2500-2800
Vitamin B2 2000-2400 2000-2800
Vitamin B6 3800-4200 2800-3000
Vitamin C 180-200 200-260
Nicotinic acid (niacinamide) 12000-15000 12000-16000
Pantothenic acid 8000-10000 10000-12000
Choline 600000-800000 800000-1000000
Biotin 50-70 60-80
Docosahexaenoic acid 120000-160000 120000-180000
Calcium 400000-600000 500000-800000
Magnesium 250000-300000 250000-300000
Zinc 5000-8000 7000-10000
Selenium 30-45 45-60
Soyabean protein powder fishy smell of the present invention is the fat oxidation oxydasis multivalence unsaturated lipid in soyabean protein powder The low molecular weight volatile induced gas such as a class alcohol, aldehyde, ketone and the acid that fat acid (mainly including linoleic acid, leukotrienes etc.) is generated afterwards, And these micromolecular compounds are most of all with different degrees of peculiar smell, that is, form the different fishy smell of soybean.Soybean protein Powder fishy smell directly limit the edible extensively of soyabean protein powder.Pregnant woman and wet nurse are more difficult to receive soyabean protein powder fishy smell, directly Connect and limit the edible of pregnant woman and wet nurse.
ANFs of the present invention refers to that digestion, absorption and utilization to nutriment have a negative impact and made The material that humans and animals produce adverse reaction includes pancreas egg enzyme inhibitor, plant hemagglutinin (Phytohemagglutinin, PHA), soybean agglutinin, antigen protein, tannin, saponin(e, phytate phosphorus, soy oligosaccharide, different Huang Ketone, the antivitamin factor --- it is one or more of in lipoxidase (abbreviation Lox), urase.
The pancreas egg enzyme inhibition factor can reduce pancreas chymotrypsin activity, growth retardation, pancreatic regeneration enlargement.It is described to plant Thing hemagglutinin includes soybean agglutinin, can damage intestinal wall, immune response, increases endogenous nitrogen output, increases endogenous Albumen endocrine.The antigen protein immune response influences intestinal wall integrality.The tannin is by forming protein carbon hydrate Thing compound, the digestion of influence protein and carbohydrate.Saponin(e can haemolysis, and influence gut permeability.Phytate phosphorus and egg White matter and trace element form compound, the digestion of influence protein and carbohydrate.Described soy oligosaccharide can flatulence, abdomen Rush down, influence Nutrients Digestion.The isoflavones can suppress production, and increase uterus.The antimicrobial agent can be to micro- life The utilization of thing, causes vitamin-deficiency.
In above-mentioned nutritious supplementary pharmaceutical, various nutrients and its addition are also by screening.
The vitamin A：The increase and reserve supply that the development of fetus body growth and parent are respectively organized in the gestational period are equal Need substantial amounts of vitamin A.Zooscopy is found：Gestational period vitamin A deficiency, can cause miscarriage, dysontogenesis, childhood Growth of animal is stagnated and bone, tooth form bad.During vitamin A wretched insufficiency, animal skeleton and other malformations can be caused.But The vitamin A of excess intake, it is also possible to cause the normal development of fetal anomaly and influence fetus.
Vitamin D：Pregnant woman be deficient in vitamin D lack not only influence itself be pregnant and production process in health status, May influence fetus and it is neonatal grow and bone calcification, and long-range influence is produced on the health after adult.
Folic acid:Folic acid is a kind of water-soluble B vitamin, and pregnant woman is higher than normal person to the demand of folic acid 4 times, pregnant early stage It is the differentiation of Foetal organ's system, the critical period of placentation, cell growth divides very vigorous.Now folic acid deficiency can be led Cause fetal anomaly.
Vitamin B12：Woman gestationperiod digestion and absorption function strengthens, it is necessary to increase be measured, if pregnant woman is deficient in vitamin B12, can occur trophism maxicell anaemia, and neonate can also suffer from anaemia.So, vitamin B12 is particularly significant to pregnant woman.
Iron：Iron is one of primary raw material of human body generation red blood cell, and metabolism is accelerated after pregnancy, the increase of iron requirement, The hypoferric anemia in pregnancy period, can not only cause pregnant woman palpitation and short breath occur, dizziness, weak, can also result in intrauterine fetal anoxia, Growth retardation, intelligence development obstacle after life is susceptible to suffer from nutritional iron deficiency anemia etc. after life within 6 months.Pregnant woman will be certainly Oneself and fetus are in utero and sufficient Blood lipids are carried out in the hematopoiesis in postpartum, therefore, in the pregnancy period it should be specifically noted that supplement chalybeate.Pregnancy period Increase in demand to various nutrition, especially iron.In addition to maintaining the need for itself, also iron is provided for fetal growth, be used to The need for supply fetal blood and histocyte are growing, and there is a great deal of be stored in fetus liver.If pregnant woman sends out Raw hypoferric anemia, not only easily occurs various complication, the influence to fetus is bigger, for example, cause fetal in utero in childbirth Hypoevolutism, low birth weight, premature labor, stillbirth, neonatal death etc..In addition, also affecting the development of fetus immune system. Therefore, the iron of pregnancy period supplement doses is necessary.
Vitamin E (or а-tocopherol):Pregnant woman is deficient in vitamin if E and is easy to cause fetal irritability, post-abortion to be difficult Become pregnant again, or cause the symptoms such as skin early ageing, trichomadesis.
Vitamin K:The K if gestational period is deficient in vitamin, its abortion ratio increase, even if survival, due to its internal fibrin ferment Lowly, easy bleeding, or cause fetal congenital blindness and MR and stillborn foetus.Therefore, pregnant woman should be noted that richness of ingesting Food containing vitamin K, to prevent postpartum neonate to cause encephalic, hemorrhage of digestive tract etc. because of vitamin K deficiency.
Vitamin B1:Vitamin B1 is water solubility, and in human body in addition to intestinal bacterium can synthesize a part, human body itself is not Energy synthetic vitamin B1, is mainly derived from food.The B1 pregnant woman of being deficient in vitamin can make neonate cease congenital athlete's foot, birth When anasarca, body temperature is low, sucks powerless, often vomiting, and limb adynamia, lethargic sleep all day or sob are faint, the morbid night crying of babies.
Vitamin B2：The B2 if ready-to-be mother is deficient in vitamin at pregnant initial stage, can be by influenceing the metabolism of nicotinic acid, and then influences The development of fetal central nervous system, causes nervous system malformation.Protein metabolism and development of fetus can be also influenceed simultaneously, fetus can be made Subchondral drilling is obstructed, and occurs skeleton deformity, and such as long bone shortens, rib-fusions symptom.If to be deficient in vitamin in pregnant latter stage B2, can cause angular stomatitis, glossitis, cheilitis, can increase premature's incidence, and premature infant and stillbirth youngster increase.
Vitamin B6：Caused vomiting of the vitamin B6 to a variety of causes, the especially vomiting of pregnancy have controls curative effect well Really, because it participates in women vivo protein, the metabolism of fat, carbohydrate and some hormones, pregnant woman needs to take VB6 When, it must take in right amount.So both to own beneficial, there is favourable to fetus.
Nicotinic acid (or niacinamide)：Nicotinic acid is exactly vitamin B3, or nicotinic acid, if during its shortage, can produce pellagra, table It is now the symptoms such as dermatitis, glossitis, oropharynx, diarrhoea and agitation, insomnia cacesthesia.The health of digestive system can be promoted, mitigated Gastrointestinal disorders, make skin is more healthy, the gentle solution of prevention is serious antimigraine, stimulate circulation, making drop in blood pressure, alleviating diarrhoea Phenomenon, the malaise symptoms for mitigating Meniere's syndrome (Menieres syndrome)；Make one physical efficiency is fully increased using food Energy, treatment oral cavity, lip inflammation, prevent halitosis, reduction cholesterol and triglyceride.
Pantothenic acid：Pantothenic acid is exactly vitamin B5, pantothenic acid, is a kind of water-soluble B vitamin, pantothenic acid tool manufacture antibody work( Can, also played an important role in terms of hair, skin and blood health is safeguarded；Generally accepted pantothenic acid and hair, the nutrition of skin State is closely related, is when hair lacks gloss or becomes sparse, and many supplement pantothenic acid are when its visible effect.Major function can be made Make and update bodily tissue, help wound healing, manufacture antibody, resist infectious disease, prevent fatigue, help resistance to compression, mitigation a variety of Antibiotic side effect and toxin, nausea of releiving.
Choline：And for pregnant woman, whether the intake of choline is enough, then the brain development of fetus is influenced whether.From bosom Start within pregnant 25 weeks, the hippocampus of supervisor's people's memory germinates, and is continued until child 4 years old.So, if in hippocampus There is choline shortage in early development, pregnant woman, may result in the nerve cell apoptosis of fetus, and newborn brain cell is reduced, and then is influenceed To brain development.
Biotin：Biotin, also referred to as w factor, are the important nutrients of our human bodies, if human body lacks biological Element, can suffer from a series of disease, and the health care belt to patient carrys out very big influence.Research finds that about 50% pregnant woman lacks Biotin.Because their shortages inform a kind of enzyme of the how proper use of biotin of body, and therefore metabolic function is caused to reduce. But, pregnant woman's also unsuitable overdose biotin, because there is the risk for causing miscarriage.
Vitamin C：The brain function that vitamin c can improve tire baby is keen, and the hemopoietic system of tire baby is perfected Enhancing with Abwehrkraft des Koepers has facilitation.If ready-to-be mother's pregnancy period famine vitamin C, is susceptible to suffer from scurvy.Rationally Replenishing vitamins C be all in itself very important with fetus to pregnant woman.Because vitamin C is must during embryo growth and development One of indispensable nutrient is particularly rapid, it is necessary to supplement enough vitamin in mid pregnancy embryo growth and development.Gestation During Determination of Vitamin C in maternal blood be gradually reduced, be only the half of pregnant early stage during childbirth, at this moment serious intake Not enough ready-to-be mother easily falls ill, and thus ascorbic supplement is timely.
Docosahexaenoic acid:There is the DHA (docosahexaenoic acid) of the title of " docosapentaenoic acid ", be that nerve synapse development must Need, it is beneficial to fetal brain and neurodevelopment, contribute to brain, the neurodevelopment of baby, be conducive to the eyesight of baby.
Calcium：Human body is sought after inorganic salts (mineral matter), and ready-to-be mother is more indispensable, and the effect of particularly calcium is even more important.Often Individual pregnant woman is required for replenishing the calcium, and pregnant woman needs 40 grams of calcium in whole period of gestation, and in pregnant late period, lower limb cramp occur in some pregnant woman. Because the generation and development and mother's physiological metabolism of fetus bone tissue are required to substantial amounts of calcium, if the content of calcium in diet is not enough Or lack sunshine etc., it can all cause ready-to-be mother's blood calcium to decline.Because the calcium needed for fetus is only obtained from parent, i.e., Make parent calcium deficiency, fetus still will draw quantitative calcium from parent, and this this may result in ready-to-be mother's bone and tooth decalcification, draws Waist disease, leg disease, bone pain, tetany and loss of tooth etc. are played, malacosteon, pelvis deformation are also occurred that when serious, even Cause difficult labour.Calcium is also critically important to nervous system, and when Determination of Calcium in Serum content is reduced, ready-to-be mother's nerve excitability increases, then Muscle is twitched, here it is described " cramp " usually.Meanwhile, fetus calcium deficiency can cause fetal bone depauperation, cause Congenital rickets etc..So, it is considerable that the pregnancy period replenishes the calcium in time.
Magnesium：Function of the magnesium to human body：The main function of magnesium ion is to allow the cell of injury to be repaired, in addition, it Bone and tooth can be allowed to generate firmer, adjustment cholesterol and the brain development for promoting fetus.Doctor says that magnesium also has a spy Point, be exactly period of gestation if the hypertension of pregnancy, doctor can add a little magnesium in drop, allow flesh in symptom management Meat, which reaches, loosens purpose.If pregnant woman's magnesium content is too low, easily trigger uterine contractile, cause premature labor.Opposite, pregnant woman's content of magnesium is too Height, is easy for causing magnesium to be poisoned, severe patient, it is also possible to suppress pregnant woman's breathing and heartbeat, so to pay special attention to during supplement magnesium.
Zinc：Period of gestation, fetus to zinc the need for measure and increase sharply, therefore pregnant woman needs to increase the supplement of zinc, to ensure Parent zinc nutrition balances the normal development with child.In fact, zinc is begun to the influence that fetal intelligence is developed from initially.I Know, development of fetus is that embryonated egg is bred by mitosis at first, and tissue and organ are gradually developed into intrauterine, And it is mitotic on condition that DNA replication dna and rna transcription, zinc be then DNA replication dna, rna transcription and enzyme needed for nucleic acid synthesis must Need constituent.First 3 months of gestation, fetus is very sensitive to various chemical factors, if pregnancy women zinc-deficiency, it is easy to lead Cause development of fetus bad or deformity.Brain is that a most fast organ earliest is developed in all organs of fetus, and mother is pregnant 18 days, Neuropile can be recognized in embryo；Later stage of pregnancy, fetal brain average minute clock is thin by nearly 20,000 nerves of differentiation and proliferation Born of the same parents.Due to zinc can promote cranial nerve cell division, growth and regenerate, so if pregnant woman because Zinc Nutrition Status is bad and caused by Fetal brain nerve cell number is reduced, and this influence be able to not will be retrieved.It is reported that the fetus of zinc deficiency, has after birth 30% is feeblemindedness.
Selenium：United States Medicine worker has found that selenium can when studying selenium with the gestational period, women breast-feeding their children and neonatal relation Pregnant woman's blood pressure is reduced, oedema is eliminated, improves vascular conditions, hypertension of pregnancy disease is prevented and treated, suppresses the canceration of gynecological tumor. In addition fetus teratogenesis can also be prevented.Domestic research confirms that pregnant woman's blood Se content is less than Newborn, also, pregnant woman Woman's blood Se content is gradually reduced with the gestational period.Reduced as far as possible during childbirth, there is the pregnant of the pregnant medical history such as miscarriage, premature labor, stillborn foetus Woman's blood Se content is significantly lower than without this medical history person again.The research of Federal University Er Chong hospitals of Germany shows, during baby due, blood Selenium level is very low, needs to absorb substantial amounts of selenium from breast milk in time, to ensure that baby normally grows.The neonatal battalion of prevention Support retardance and ensure the normal development of brain, this just makes the Se content of breast milk seem particularly important.Therefore, the gestational period and nursing period The appropriate selenium of women's daily iron supplement, is highly beneficial to neonate and the health of itself.How selenium-supply is good by pregnant woman, and amount must Suitably, if it exceeds needed by human body, it is possible to can trigger pneumonia, the illness such as Liver and kidney function is degenerated, and jeopardize the life of fetus. If taking in substantial amounts of selenium, it can also cause to seriously endanger to body.
The auxiliary material is included in sucrose, lactose, glucose, starch, cellulose etc..
Pregnant woman and the wet nurse nutritious supplementary pharmaceutical easily brews form with particle, powder or paste etc. to be present.
The container of exotic material of the present invention, the wall of the container is pressed into in special " chevron shaped " Fall into structure, the bottom of container is pressed into caves in structure with special helical form, when rushing hot water by hot water drift, can produce whirlpool Vortex, helps the dissolving and mixing of nutritious supplementary pharmaceutical powder or particle.
It is preferred that the structure of container includes vessel, the top of the vessel is provided with closure, and bottom is provided with outlet, The outlet is sealed by encapsulant, and the lateral wall of the vessel is provided with oblique groove and neck, the vessel The position corresponding with the oblique groove is fin on madial wall.
The oblique groove is in the arrangement of falling herringbone, and the fin corresponding with the oblique groove is also in the arrangement of falling herringbone.
The bottom of the vessel is provided with helical groove, and the madial wall of vessel is close in one end of the helical groove Arrangement, the other end extends to outlet.
Top and bottom in the vessel are respectively equipped with a filter.
The closure includes three-layer sealed film, and three-layer sealed film is respectively CPP films, aluminium film and PET film from inside to outside.
The madial wall of the container is provided with oblique fin, and when hot water is out of top injection vessel, hot water can Flowed along fin, enhance stirring action of the current to content, so that hot water mixes more abundant with content, keep away The waste of content is exempted from.
High-temperature resistant container of the present invention, wherein high temperature resistant refer to temperature more than 120 DEG C, 150-180 DEG C of preferable temperature. The exotic material includes but is not limited to：Polythene PE, polypropylene PP (fusing point is up to 167 DEG C), expandable polystyrene EPS (heat-resistant deforming temperature is up to more than 280 DEG C), PEN/PET polyethylene naphtalates, the ethylene-vinyl alcohol containing high barrier material are total to One kind or several in polymers EVOH, Vingon PVDC, nylon MXD 6, the multilayer materials of Si oxide evaporation film etc. Kind, optimal ethylene PE, polypropylene PP, such packing plastics is in addition to good processability, without toxicity, and topmost feature is Heat-resistant deforming temperature is up to more than 150 DEG C, and these material requirements are in the case of 120 DEG C, 1O-20min sterilizations or heating, outward appearance Shape, quality are without obvious change, without noxious material dissolution.The boiling water of boiling is poured, packing box will not also be deformed, thus energy The local flavor of food is kept completely.The features such as container has high temperature resistant, anti-embrittlement, protection against the tide, anti-oxidant, UV radiation, bag Dress food does not produce damaged container, content leaks and microorganism secondary pollution and light and heat in storage process makes content Rotten situations such as
The application method of the product of the present invention：It can be positioned in special machine, with high pressure boiling water brewing, rush well-done soup Liquid is convenient to flow out.
The upper and lower surface of vessel of the present invention can be punctured by the puncturing head of special construction；It is resistant to 15BAR boiling Water brewing, realizes extraction function；Container shapes make in boiling water brewing, and vortex can be produced in container, accelerate capsule contents Dissolving；Solution rotating in container can be driven in matched specific function machine (i.e. apparatus mentioned above) inner rotation Mixing, accelerates the dissolving and mixing of capsule contents equal
Vessel can be placed in specific machine, driven container to rotate by the special device of machine, accelerated in container Contents melting.The nutritious supplementary pharmaceutical particle of 20-100 mesh particle size ranges coordinates the special structure of container of the present invention needing punching During decocting, this container is put into special machine, the lancet of machine punctures closure, high-temperature high pressure water, which enters, to be held Dissolving content in device body, by filter, the lancet of container is pierced into the other end, by being pooled to outlet, entirely Process was completed in 1 minute, and particle is completely dissolved and noresidue.Container after use is directly discarded, and machine is not directly contacted with The material of the inside, without cleaning robot.It is simple and convenient, it is time saving and energy saving, without cleaning robot.
Invention additionally discloses described pregnant woman and the preparation method of wet nurse's nutritious supplementary pharmaceutical product, comprise the following steps：
(1) prepared without fishy smell, without ANFs protein powder；
(2) prepared by core nutrient premixed powder；
(3) prepared by selective nutrient premixed powder；
(4) step (1) protein powder and step (2) core nutrient and the selective nutrient mixing of step (3), obtain powder End：
(5) pelletize：Step (4) powder mixes with auxiliary material, pelletized；
(6) it is filling：The pregnant woman prepared and wet nurse are loaded in high-temperature-resistant high-pressure-resistant container with nutritious supplementary pharmaceutical particle, it is close Envelope.
Described in above-mentioned steps (1) following two methods can be used without fishy smell, without the preparation of ANFs protein powder. The addition of good protein powder can calculate raw material dosage according to the content of the protein component in good protein powder raw material, The content of protein component in the good protein powder raw material consumption=protein addition ÷ good protein powder raw materials.
A. soyabean protein powder is commercially available, and soyabean protein powder purchased in market has to comply with GB/T 22493-2008 requirements, table 5-7 Described in require.
The soyabean protein powder organoleptic requirements of table 5
Project Quality requirement
Form Powder, no caking phenomenon
Color and luster White is to light yellow
Smell With the intrinsic smell free from extraneous odour of soyabean protein powder
Impurity The foreign substance being visible by naked eyes
The soyabean protein powder quality annotation of table 6
The soyabean protein powder sanitary index of table 7
The soyabean protein powder for meeting above-mentioned quality requirement is chosen, fishy smell in protein powder, passivation are eliminated using physical method ANFs, preferably heat treatment method.Heat treatment method includes：
Steam heats：Handled including normal pressure steam treatment and high-pressure water vapor.Normal pressure steam treatment is will be big After beans pulverize and sieve, mixed with vapours rapidly, reach moistureIn 90-100 DEG C of normal heating processingRapid cooling, you can inactivate lipoxidase, finished product better flavor eliminates raw meat in protein powder Taste, passivation ANFs, and improve the nutritive value of product.High-pressure water vapor processing is after soybean is pulverized and sieved, extremely In pressure cooker, 110-130 DEG C of temperature, 10-20 minute, pressure 80-110kPa can eliminate fishy smell in protein powder, be passivated anti-battalion Support the factor.
Spray hot wind passivating technique：Temperature is 230-310 DEG C of the direct spray treatment soyabean protein powder of hot blast, can be by fat Oxidizing ferment and ANFs passivation.
The instantaneous high-temperature that pressurizes is handled：When soy meal is by shelltube heat exchanger, pressure is adjusted to 2Kg/cm2, and in 130 DEG C heat 2 seconds, be cooled to room temperature immediately afterwards, can effectively remove beany flavor, passivation ANFs, and soybean protein Substantially it is undenatured.
Hot water milled processed：In the warm water that people's beans are first immersed to 40 DEG C or so, adding hot water makes its temperature reach 80-100 DEG C, and slurry, rapid passivation lipoxidase and ANFs are ground to form at such a temperature, and gained soya milk product is substantially without beans Fishy smell.
Xeothermic Passivation Treatment：While big bean crushing is removed the peel, steam is xeothermic to 100 DEG C, by lipoxidase and can resist Trophic factors is passivated.After cooling, add water toExtrusion cooking is carried out again.And through journeys such as drying, cooling, millings Sequence, produces the soy meal of better flavor.
Blanching treatment：Full soybean is handled through water blancing can also be passivated lipoxidase and ANFs.For dry Dry soybean, with 10 times of amount boiling water, need to heat 20 minutes.And with the soaking soybean of 4 hours of water, then blanching 10 minutes Reach the purpose of smelling removal.It should be stirred vigorously during blanching treatment, to promote the transmission of heat, the de- beany flavor of enhancing and the anti-battalion of passivation Support factorial effect.
Microwave heating treatment method：The characteristics of microwave is heated is to effectively supply heat energy, but does not change containing for soybean material Water, and can elevate the temperature rapidly, so that effectively passivation fatty acid oxidase and ANFs.Microwaved mistake The basic free from beany flavor of soybean.
General heating method can effectively remove unstability ANFs, but can not remove the soybean protein of heat endurance Powder antigen and flatulence factor, and mesh, often occur underheat and excessively etc. phenomenon.Underheat can not eliminate anti-battalion The factor is supported, over-heating can then destroy amino acid (lysine, arginine and part sulfur-containing amino acid) and vitamin；Heating process In can also cause amino acid and carbohydrate to react, such as lysine and reducing sugar reaction generate insoluble compound, cause egg White matter digestibility declines.Not enough for general heating method, the present invention preferably steam heats and spray hot wind Passivation Treatment.Heat Wind, which sprays passivating technique and steam heating, has the heat treatment short time short, can both make in soyabean protein powder to thermo-responsive ANFs activity eliminate, protein chain can also be deployed, amino acid residue exposure, make it easy to by egg in body White enzyme hydrolysis.Prolonged heating is avoided to cause amino acid to be reacted with carbohydrate simultaneously, such as lysine and reducing sugar reaction Insoluble compound is generated, causes protein digestibility to decline.
In order to reach the protein for obtaining high-quality, preferably soyabean protein powder, including following step are prepared by following methods Suddenly：
1. dry type is heat-treated：After defatted soy flour addition water, dry type heat treatment；
2. extract：Extracted using vertical type multifunctional dynamic extraction pot, the soy meal after dry type heat treatment, after addition distilled water Extract, be stirred continuously it is lower boiled, it is this hydrolysis with extraction process in, often produce foam, be subsequently cooled to room Warm liquid phase mixture；
3. separation of solid and liquid：Liquid phase mixture is filtered or centrifuged, and obtains filtrate or supernatant；
4. decompose：Filtrate or centrifuged supernatant are boiled, stirring is until filtrate becomes muddy and produces precipitation, and boiling time should The score solution liquid untill no longer producing precipitation；5. separation of solid and liquid：Using centrifugal filtration process, filtration method or dehydrator are inhaled by decomposition Granule in liquid separation of solid and liquid, suspended liquid, obtains the filtrate containing soluble component；
6. it is spray-dried：Filtrate containing soluble component is spray-dried (190-200 DEG C of EAT, temperature of outgoing air 85 DEG C), obtain no fishy smell, the water-soluble soybean protein powder without ANFs.
1. above-mentioned steps are added after 2-5% distilled water described in dry type heat treatment to defatted soy flour, are put into rotary kiln and are entered Row dry type is heat-treated, and temperature is 110-120 DEG C, and the time needs 1-2 hours；
Above-mentioned steps 2. extract described in dry type heat treatment after soy meal, addition distilled water after extract, material-water ratio is 1: 6-10 (preferably 1:8), be stirred continuously it is lower boiled up to more than 6 hours, be subsequently cooled to room temperature and obtain liquid phase mixture.At this Plant in hydrolysis and extraction process, often produce foam
Filtered, or just poured into after cooling in sedimentator after above-mentioned 3. liquid phase mixture described in separation of solid and liquid cooling, Liquid phase and residue containing nutrition composition are separated into obtain filtrate or centrifuged supernatant.This filtrate or centrifuged supernatant are one Plant with dark and-fixation gas turbidness liquid；In addition to containing protein and various amino acid, also containing various mineral constituents (magnesium, calcium, manganese, iron etc.), carbohydrate, the catabolite of lecithin and lecithin, the sexavalence phosphate of cephalin and inositol.
Above-mentioned that 4. filtrate or centrifuged supernatant are boiled described in decomposition, continuously stirring makes filtrate change muddy and produces to sink Form sediment.The boiling stage can promote the dissolving of the useful soluble component of soybean；Continuously stir step by the protein in filtrate and Amino acid is separated.Untill described boiling time should no longer be produced according to precipitation.It is preferred that boiling 3 hours.In order to control now institute The foam of generation, can adjust the temperature of heating.
Granule in above-mentioned 5. separation of solid and liquid in preferred dehydrator suspended liquid, obtains the filtrate containing soluble component.
Above-mentioned 6. the spray drying kind spray drying, 190-200 DEG C of EAT, 85 DEG C of above-mentioned steps of temperature of outgoing air (2) mixing of core nutrient described in, wherein core nutrient is commercially available, can be calculated according to the active constituent content of raw material Certain core nutrient effectively contains in raw material dosage, the core nutrient raw material dosage=certain core nutrient addition ÷ raw material Amount.
Above-mentioned steps (3) selectivity nutrient can calculate raw material dosage, from the market according to the active constituent content of raw material The suitable raw material of selection simultaneously determines its active constituent content, presses the conversion of column count formula：Raw material dosage=certain nutrient addition Certain nutrient effective content in ÷ raw materials.
Above-mentioned steps (4) protein powder, core nutrient, selective nutrient are proportionally mixed, and obtain powder：
Above-mentioned steps (5) are pelletized：Pelletized using dry or wet, preferably dry granulation, add auxiliary material, other special requirements Nutritional ingredient and appropriate flavouring, aromatic；The weight ratio of the auxiliary material and step (4) powder is 1-5:1 (preferably 2.3: 1)；The auxiliary material is included in sucrose, lactose glucose, starch, cellulose etc..
It is filling in above-mentioned steps (6)：In the production line with nontoxic inert gas (nitrogen or carbon dioxide etc.) protection On, quantitatively tamp pregnant woman and wet nurse uses nutritious supplementary pharmaceutical particle using Machine automated, closure passes through the modes such as heat seal and appearance Device is combined, it is ensured that sealing, and the inert gases such as nontoxic nitrogen or carbon dioxide are filled with container.
Present invention also offers the pregnant woman and wet nurse the application of pregnancy complication anaemia is being reduced with nutritious supplementary pharmaceutical.
Beneficial effects of the present invention are illustrated by following test examples
The pregnant woman of test example one and wet nurse's hypoferric anemia and its controlling experiment
Prescription：
Treatment method：10 hospital diagnosis are volunteer (the Excluded cases non-iron deficiency anemia, or iron-deficient of pregnant woman anemia Anaemia pole severe person；Allergic constitution and those who are allergic to this drug；Merging angiocarpy, the cerebrovascular, liver, kidney and hemopoietic system, other are serious Primary disease, mental patient；Protopathy is not controlled, continuous bleeding Anemia) , AgeTake after mixing it with water above-mentioned Nutritious supplementary pharmaceutical, 2 times a day, 1 every time, and 30 days are 1 course for the treatment of, does not take other liter of blood during medication, mends iron medicine.
Criterion of therapeutical effect：It is effective (clinical symptoms are clearly better, severity of anemia classification by severe switchs to slightly, improvement 2 grades with On), effectively (clinical symptoms take a favorable turn, severity of anemia improve 1 grade), invalid (clinical symptoms and severity of anemia without improve).
Clinical observation shows, above-mentioned nutritious supplementary pharmaceutical treats status of iron deficiency in pregnant women, effective 9, wherein effective 6.
Two pregnancy period of test example different phase selects influence of the nutrient prime replenisher to pregnant mouse
Prescription：
Zoopery
Adult healthy cleaning grade female rats (Wistar) 75 (210~230g of body weight), male rat 30 (280~ 300g).Male and female rat quantity presses 2:1 is mated, and pregnant mouse 50 is obtained altogether.According to the difference for giving sample time, by Pregnant rats It is divided into pregnant preceding group (i.e.：Start to gavage sample within 1 week before mating), pregnant early stage group, second trimester group, totally 5 groups of pregnant late period and control group, Every group 10.Above-mentioned nutritious supplementary pharmaceutical is given through gavage by 0.1g/kg.bw, gavage amount is that 1.0ml/kg.bw control groups are gavaged The physiological saline of amount.(2) food ration and body weight of pregnant mouse were weighed every 3 days.Record the fetus sum of spontaneous labor, live births, Stillborn foetus number, monster number, measure its growth indexes:It is height (head stern length), tail length, body weight, nose heave.(3) pregnant mouse blood, separation are gathered Serum, using atomic absorption spectroscopy determination calcium, magnesium, iron, zinc content.(4) weigh fetus tissue and digest, determine tire Young Calcium In Tissues, magnesium, iron, the content of zinc.
Results of animal shows, pregnant preceding group, the pregnant mouse body weight increase amount of pregnant early stage group pregnant early stage apparently higher than Control group (P<0.05)；The pregnant mouse body weight total augment weight amount that above-mentioned nutritious supplementary pharmaceutical is given during second trimester is significantly higher than other each groups (P <0.05).From each group farrowing quantity, the pregnant mouse litter size of each group for giving above-mentioned nutritious supplementary pharmaceutical is more than control group, and difference has Statistical significance (P<0.05).Pregnancy period give above-mentioned nutritious supplementary pharmaceutical each group fetus Calcium In Tissues content be above control group and Pregnant preceding supplementation group (P<0.05)；The fetus tissue content of magnesium of group and second trimester group is higher than control group (P before pregnant<0.01,P<0.05)； The Zn content of pregnant late period group is higher than other each groups (P<0.05).
The ANFs degree of passivation assay method of test example three
When being heat-treated, it is necessary to assure the intensity of heat treatment is suitable.Then ANFs destruction is inadequate for underheat；Plus Hot excessively then rate of ultilization of amino acid declines, and can reduce the biological efficiency of protein.It is many to determine urease activity in actual production Judge the degree of passivation of the tryptose factor, react underheat；Using protein solubility as judging albumen powder over-heating Index.
Urease activity is determined：The optimum condition of urease activity in nutritious supplementary pharmaceutical (albumen powder) is determined using nessler reagent For：Wavelength 415nm, developer consumption 1mL, urea concentration 3%, 35 DEG C of reaction temperature, reaction time 7min.Nutritious supplementary pharmaceutical The best use of pH of urase is 7.0 in (albumen powder), and optimal reactive temperature is 35 DEG C, and urase stores 3h between 25~40 DEG C to be had Preferable heat endurance, enzyme activity retention rate is more than 80%.Urase is tried to achieve using Lineweaver-Burk double-reciprocal plot methods Vmax is 0.17mmol/min, and Km is 0.017mol/L.
Protein solubility is determined：The 1.5g albumen powders after finely ground (60 mesh) are weighed in 250mL beakers, are added 75mL, 0.2%KOH solution, stir 20min in magnetic stirring apparatus.50mL liquid is gone in centrifuge tube again, with per minute 2700r centrifugations 10 minutes.Aspirate supernatant 15mL, with Kjeldahl nitrogen determination protein content therein.This content phase When the albumen quality dissolved in 0.3 gram of original sample.
Protein solubility (PS) is calculated as follows：
PS (%)=(V-V0) * C*0.014*6.25/0.3*100%
In formula：
PS --- protein solubility, %；
C --- hydrochloric acid standard solution concentration, mol/L；
V --- required standard acid volume (mL) during titration sample
V0 --- required standard acid volume (mL) during titration blank
As PS ＞ 85%, then it is assumed that albumen powder heats not enough；And as PS ＜ 75%, then it is assumed that albumen powder is heated Overtreating；And PS is at 75%~85% or so, then it is assumed that the quality of albumen powder is preferable.
As a result table, 8
The spray hot wind passivation temperature of table 8 is to ANFs activity influence
Soyabean protein powder sequence number Temperature (DEG C) Urease activity Protein solubility
1 200 3 91%
2 230 0 85%
3 300 0 82%
4 310 0 80%
5 320 0 75%
As a result, hot blast direct spraying processed soybeans albumen powder of the present invention at 230-310 DEG C, sprays good passivation effect, greatly It is high to the active elimination factor of thermo-responsive ANFs in legumin powder.
The package materials selection of test example four
Consider from packaging for foodstuff angle, shelf of this form of capsule stated clearly with the present invention as carrier than other forms Phase is longer.Shelf life is all vital to the food enterprises and consumer.The present invention is directed to the influence of Food Shelf-life Factor (product in itself and its function, environment and packaging material etc.) takes corresponding measure.(1) shelf life is by product The influence of microorganism, enzyme and biochemical reaction.Some harmful substances or microorganism that microorganism itself produces make use of in product Some nutritional ingredients generation other materials, so as to have impact on the shelf life of product.The nutritious supplementary pharmaceutical powder (particle) of the present invention Corresponding sterilizing measure is employed before packing, is dispensed in the cleaning shop for meeting GMP requirements, full of inert gas Sealed in space capsule, it is ensured that product is in itself without microorganism pollution.Substantial amounts of data shows that the effect of enzyme is to cause shelf life The major reason of problem, nutritious supplementary pharmaceutical powder (particle) of the invention employs corresponding enzyme high-temperature inactivation measure before packing, Ensure that inactive enzyme exists product in itself.Change in terms of biochemistry focuses on to show in oxidation reaction, and biochemical reaction is main Influence the outward appearance of product, local flavor and mouthfeel.The nutritious supplementary pharmaceutical powder (particle) of the present invention is in the space capsule full of inert gas Sealed, capsule is gathered using high temperature resistant, air-locked material polythene PE, polypropylene PP (fusing point is up to 167 DEG C), expandability Styrene EPS (heat-resistant deforming temperature is up to more than 280 DEG C), PEN/PET polyethylene naphtalates, the second containing high barrier material In alkene-ethenol copolymer EVOH, Vingon PVDC, nylon MXD 6, the multilayer materials of Si oxide evaporation film etc. It is middle a kind of or a kind of, closure includes three-layer sealed film, and three-layer sealed film is respectively CPP films, aluminium film and PET from inside to outside Film.The sealed sealed capsule of lid thermal coupling can ensure that product no oxygen itself, will not occur redox reaction.(2) influence The environmental factor of shelf life has：Storage temperature, relative humidity, moisture etc..(3) different packaging materials its breathe freely Property, sealing, translucency, hinder moist etc. all different, so as to influence the shelf life of product.The present invention nutritious supplementary pharmaceutical powder ( Grain) capsule use high temperature resistant, air-locked material, include but is not limited to：Polythene PE, polypropylene PP (fusing point is up to 167 DEG C), Expandable polystyrene EPS (heat-resistant deforming temperature is up to more than 280 DEG C), PEN/PET polyethylene naphtalates, material containing high barrier Ethylene-vinyl alcohol copolymer EVOH, Vingon PVDC, the nylon MXD 6 of material, the MULTILAYER COMPOSITE of Si oxide evaporation film etc. One or more in material, preferably polythene PE, polypropylene PP.Closure includes three-layer sealed film, and three-layer sealed film is by interior It is respectively outwards CPP films, aluminium film and PET film.The sealed sealed capsule good airproof performance of lid thermal coupling, it is ensured that airtight, impermeable Light, moisture barrier property are good.It see the table below 9,10：
Table 9
Table 10
Stability The term of validity Transport Preservation
Nutritional supplementation agent capsules It is good More than 2 years It is convenient Easily
Other nutritious supplementary pharmaceutical powder Typically Less than 1 year It is inconvenient It is not easy
Product of the invention also has following features in summary
(1) it is convenient.Simple to operate, any one new hand can easily make one glass of safety, reeky pregnant woman and wet nurse Use nutritious supplementary pharmaceutical.Without cumbersome cleaning, pregnant woman and wet nurse's nutritious supplementary pharmaceutical are carried out, direct returnable just can be with.
(2) safety.The supplementary material of high-quality is selected, in the factory building for meeting GMP requirements, using most stringent of similar to medicine Standard processing procedure, pregnant woman is packed by international advanced space capsule technology and wet nurse uses nutritious supplementary pharmaceutical particle, and insert nitrogen or The revolution sexual system of carbon dioxide etc., overwhelms the current production technology of all.Without unpacking, dress directly puts machine into, rushes Boil, extracted after be also convenient for reclaim.
(3) it is fresh.Capsule is independent packaging, and nitrogen charging, aluminum foil is packed, and it is all fresh often to open each cup.It is complete Under the protection of hermetically sealed inflated with nitrogen packaging, fresh, the anti-oxidation of pregnant woman and wet nurse's nutritious supplementary pharmaceutical can be effectively kept, is made Storage life is reached 2 years as long as, because he can pass through the time of 2 years, can reach the distance of international space station, therefore he is called Space food, when capsulae vacuus.
(4) stay in grade.Pregnant woman and wet nurse are that automation is tamped on same production line with nutritional supplementation agent capsules, The stay in grade of every glass of pregnant woman and wet nurse's nutritious supplementary pharmaceutical can be ensured.
(5) it is steaming hot.By high pressure boiling water brewing, extraction, what is obtained is reeky pregnant woman and wet nurse's nutritional supplementation Agent.
Brief description of the drawings
Fig. 1 is the structural representation of inventive container；
Fig. 2 is the polycrystalline substance schematic diagram in inventive container；
Fig. 3 is the sealing cover structure schematic diagram of inventive container.
Embodiment
The structure of the inventive container of embodiment 1
As shown in figure 1, inventive container includes vessel 1, the top of the vessel 1 is provided with closure 2, bottom Provided with outlet 3, the outlet 3 is sealed by encapsulant, and the lateral wall of the vessel 1 is provided with oblique groove 4 and neck 5, The position corresponding with the oblique groove 4 is fin on the madial wall of the vessel 1.Oblique groove 4 is constituted together with fin The structure of outer recessed convex.When in use, the inside of vessel 1 is used for holding the contents such as ground coffee or milk tea powder the present invention Thing, the neck 5 is used for carrying out being connected fixation with external equipment (it carries out brewing operation to container).
Inventive container, wherein the oblique groove 4 is in the arrangement of falling herringbone, the fin corresponding with the oblique groove 4 In the arrangement of falling herringbone.The fin of falling herringbone is set on the madial wall of vessel 1, can make to enter inside vessel 1 Hot water content is more fully stirred.
As shown in Fig. 2 inventive container, wherein the bottom of the vessel 1 is provided with helical groove 6, the spiral is recessed The madial wall arrangement of vessel 1 is close in one end of groove 6, and the other end extends to outlet 3.The bottom of vessel 1 is in infundibulate, When madial wall of the soup along vessel 1 flows to bottom, soup flows to 3 positions of outlet, flow process along helical groove 6 In, in the presence of helical groove 6, soup is rotated, and further enhances the mixability of hot water and content.
When soup collects in the outlet port of the bottom of vessel 1, encapsulant herein can be by the thimble of equipment Pierce through, rush well-done soup and flow out from there.
Inventive container, wherein the top and bottom in the vessel 1 are respectively equipped with a filter 7.Filter 7 is Paper filter, bulky grain, impurity that can be in filter water and content etc.；Can also be without filter, no filter only influences Outward appearance and mouthfeel, do not influence nutrition and taste.
As shown in figure 3, inventive container, wherein the closure 2 includes three-layer sealed film, three-layer sealed film is from inside to outside Respectively CPP films 201, aluminium film 202 and PET film 203.Wherein, CPP films 201 can set up sealedly first road barrier, aluminium film 202 Completely isolated water and air, PET film 203 can strengthen sealing effectiveness.
The madial wall of inventive container is provided with oblique fin, when hot water is out of top injection vessel 1, hot water energy It is enough to be flowed along fin, stirring action of the current to content is enhanced, so that hot water mixes more abundant with content, Avoid the waste of content.
The upper and lower surface of vessel 1 in the present invention can be punctured by the puncturing head of special construction；It is resistant to 15BAR boiling water Brewing, realizes extraction function；Container shapes make in boiling water brewing, and vortex can be produced in container, accelerate the molten of capsule contents Solution；In matched specific function machine (i.e. apparatus mentioned above) inner rotation solution rotating in container can be driven to mix Close, accelerate the dissolving of capsule contents and be well mixed.
Vessel 1 can be placed in specific machine, driven container to rotate by the special device of machine, accelerated container Contents melting.The wall of the container is pressed into be caved in structure with special " chevron shaped ", and the bottom of container is pressed into Caved in structure with special helical form, when rushing hot water by the special hot water drift of particular machine, eddy-currents can be produced (as schemed 2) dissolving and mixing of capsule 's content, are contributed to.
Bulky grain, impurity in paper filter setting up and down 7 in vessel 1, filter water and content etc., it is middle The content of sequence processing is placed through, closure 2 is combined by the modes such as heat seal and vessel 1, it is ensured that filled in sealing, container The inert gases such as nontoxic nitrogen or carbon dioxide are filled up, play a part of extending the shelf life sterilizes again.Need brewing soup When, this container is put into special machine in (such as capsule type coffee machine or capsule soy bean milk making machine), the lancet of machine will be close Capping 2 is punctured, and high-temperature high pressure water enters dissolving content in vessel 1, and by filter, container is pierced into the other end Lancet, by being pooled to outlet, one glass of giving off a strong fragrance delicious nutritious supplementary pharmaceutical, coffee or soya-bean milk are formed from the inflow of outlet 3 cup. Whole process is 1, completed in 2 minutes.Container after use is directly discarded, and machine is not directly contacted with the material of the inside, without clear Washing machine device.It is simple and convenient, it is time saving and energy saving, without cleaning robot.
Embodiment 2 is prepared without ANFs good protein powder
1. dry type is heat-treated：Defatted soy flour is added after 2% distilled water, rotary kiln is put into and carries out dry type heat treatment, temperature Spend for 110 DEG C, the time needs 2 hours；
2. extract：Extracted using vertical type multifunctional dynamic extraction pot, the soy meal after dry type heat treatment, after addition distilled water Extract, material-water ratio is 1:8.Be stirred continuously it is lower boiled up to more than 6 hours, it is this hydrolysis and extraction process in, often Foam can be produced.It is subsequently cooled to room temperature.
3. separation of solid and liquid：Filtered, or just poured into after cooling in sedimentator after liquid phase mixture is cooled down, battalion will be contained The liquid phase and residue for supporting component are separated.
4. decompose：Filtrate is boiled, to promote the dissolving of the useful soluble component of soybean；In order in filtrate Protein and amino acid are separated, and this filtrate is boiled in autoclave pan, and continuously stirs.Now, filtrate becomes muddy and produced Precipitation, boiling time should typically be needed 3 hours or so untill no longer producing precipitation.
5. separation of solid and liquid：Using the granule in centrifugal filtration process, suspended liquid, the filtrate containing soluble component is obtained.
6. it is spray-dried：Filtrate containing soluble component is spray-dried (190-200 DEG C of EAT, temperature of outgoing air 85 DEG C), obtain no fishy smell, the water-soluble soybean protein powder without ANFs.
Embodiment 3 is prepared without ANFs good protein powder
1. dry type is heat-treated：Defatted soy flour is added after 5% distilled water, rotary kiln is put into and carries out dry type heat treatment, temperature Spend for 120 DEG C, the time needs 1 hour；
2. extract：Extracted using vertical type multifunctional dynamic extraction pot.After soy meal after dry type heat treatment, addition distilled water Extract, material-water ratio is 1:10.It is being stirred continuously lower boiled up to more than 6 hours；
3. separation of solid and liquid：Filtered, or just poured into after cooling in sedimentator after liquid phase mixture is cooled down, battalion will be contained The liquid phase and residue for supporting component are separated；
4. decompose：Filtrate is boiled, to promote the dissolving of the useful soluble component of soybean；In order in filtrate Protein and amino acid are separated, and this filtrate is boiled in autoclave pan, and continuously stirs.Now, filtrate becomes muddy and produced Precipitation, boiling time should be needed 3 hours untill no longer producing precipitation；
5. separation of solid and liquid：Using centrifugal filtration process, inhale in filtration method or dehydrator, preferably dehydrator, suspended liquid Granule, obtains the filtrate containing soluble component.
6. it is spray-dried：Filtrate containing soluble component is spray-dried (190-200 DEG C of EAT, temperature of outgoing air 85 DEG C), obtain no fishy smell, the water-soluble soybean protein powder without ANFs.
Embodiment 4 is prepared without ANFs good protein powder
Satisfactory albumen powder is bought, after sieving, is mixed with vapours rapidly, reaches moisture In 90-100 DEG C of normal heating processingMinute, rapid cooling, you can inactivate lipoxidase, finished product better flavor, Fishy smell in protein powder, passivation ANFs are eliminated, and improves the nutritive value of product.High-pressure water vapor processing be by After soybean pulverizes and sieves, into pressure cooker, 110-130 DEG C of temperature, 10-20 minute, pressure 80-110kPa can eliminate protein Fishy smell, passivation ANFs in powder.
Embodiment 5 is prepared without ANFs good protein powder
Satisfactory albumen powder is bought, can in the direct spray treatment soyabean protein powder of hot blast that temperature is 232-310 DEG C Lipoxidase and ANFs are passivated.
Embodiment 6 is prepared without ANFs good protein powder
Satisfactory albumen powder is bought, after sieving, into pressure cooker, 110-130 DEG C of temperature, 10-20 minute, pressure 80-110kPa, can eliminate fishy smell in protein powder, passivation ANFs.
Embodiment 7
Component table
Pregnant woman is well mixed with powder in upper table, and pregnant woman, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), pregnant woman is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Wet nurse is well mixed with powder in upper table, and wet nurse, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), wet nurse is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Embodiment 8
Component
Pregnant woman is well mixed with powder in upper table, and pregnant woman, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), pregnant woman is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Wet nurse is well mixed with powder in upper table, and wet nurse, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), wet nurse is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Embodiment 9
Pregnant woman is well mixed with powder in upper table, and pregnant woman, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), pregnant woman is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Wet nurse is well mixed with powder in upper table, and wet nurse, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), wet nurse is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Embodiment 10
Pregnant woman is well mixed with powder in upper table, and pregnant woman, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), pregnant woman is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
Wet nurse is well mixed with powder in upper table, and wet nurse, which is made, using preferred dry granulation uses nutritious supplementary pharmaceutical particle, On the production line protected with nontoxic inert gas (nitrogen or carbon dioxide etc.), wet nurse is quantitatively tamped using Machine automated Nutritious supplementary pharmaceutical particle is used, closure is combined by the modes such as heat seal and container (embodiment 1), it is ensured that filled in sealing, container The inert gases such as full nontoxic nitrogen or carbon dioxide.
It is foregoing to the present invention specific illustrative embodiment description be in order to illustrate and illustration purpose.These descriptions It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should With so that those skilled in the art can realize and using the present invention a variety of exemplaries and A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.

Claims (10)

1. the pregnant woman and wet nurse of a kind of instant use nutritious supplementary pharmaceutical product, it is characterised in that be by nutritious supplementary pharmaceutical and resistance to The container of high-temperature material composition is constituted；The nutritious supplementary pharmaceutical is put into exotic material container, sealing container, is filled in container Full inert gas；The nutritious supplementary pharmaceutical includes following weight parts composition：
15~35 parts of good protein,
1~10 part of nutrient,
35~84 parts of auxiliary material.
2. the pregnant woman and wet nurse of a kind of instant as claimed in claim 1 use nutritious supplementary pharmaceutical product, it is characterised in that institute Stating nutritious supplementary pharmaceutical includes following parts by weight ingredient：
25~30 parts of good protein,
2~5 parts of nutrient,
50~69 parts of auxiliary material.
3. the pregnant woman and wet nurse of a kind of instant as claimed in claim 1 use nutritious supplementary pharmaceutical product, it is characterised in that：Institute The good protein stated is without fishy smell, without ANFs.
4. the pregnant woman and wet nurse of a kind of instant as claimed in claim 1 use nutritious supplementary pharmaceutical product, it is characterised in that：Institute Stating nutrient includes core nutrient and selective nutrient, and wherein core nutrient is to be made up of following weight than component
Table 1
Wherein, selective nutrient include following weight than composition more than one.
Table 2
Selective nutrient Pregnant woman (daily μ g) Wet nurse (daily μ g) Vitamin E (а-TE) 4000-14000 5000-17000 Vitamin K 24-80 26-85 Vitamin B1 600-2800 600-3000 Vitamin B2 600-2800 600-3000 Vitamin B6 900-4400 700-34000 Vitamin C 40000-230000 60000-300000 Nicotinic acid (niacinamide) 5000-18000 6000-18000 Pantothenic acid 2400-12000 2800-14000 Choline 160000-840000 200000-1040000 Biotin 16-80 20-100 Docosahexaenoic acid 60000-200000 60000-200000 Calcium 300000-800000 300000-800000 Magnesium 110000-370000 100000-330000 Zinc 3000-10000 4000-12000 Selenium 20-55 25-65
5. the pregnant woman and wet nurse of a kind of instant as claimed in claim 4 use nutritious supplementary pharmaceutical product, it is characterised in that：Its Center heart nutrient is to be made up of following weight than component
The core nutrient weight ratio of table 3
Core nutrient Pregnant woman uses (daily μ g) Wet nurse uses (daily μ g) Vitamin A 400-600 800-1000 Vitamin D 6-8 8-10 Vitamin B12 3.6-4.0 4.0-5.0 Folic acid 300-400 300-400 Iron 15000-16000 14000-15000
Wherein, selective nutrient weight ratio is shown in Table 4
The selective nutrient weight ratio of table 4：
6. the pregnant woman and wet nurse of a kind of instant as claimed in claim 1 use nutritious supplementary pharmaceutical product, it is characterised in that institute The wall of the container for the exotic material stated is pressed into be caved in structure with special " chevron shaped ", and the bottom of container is pressed Caved in structure into special helical form, when rushing hot water by hot water drift, eddy-currents can be produced, the molten of nutritious supplementary pharmaceutical is helped Solution and mixing.
7. the pregnant woman and wet nurse of a kind of instant as claimed in claim 4 use nutritious supplementary pharmaceutical product, it is characterised in that institute Stating the structure of container includes vessel, and the top of the vessel is provided with closure, and bottom is provided with outlet, the outlet quilt Encapsulant is sealed, the lateral wall of the vessel be provided with oblique groove and neck, the madial wall of the vessel with The corresponding position of the oblique groove is fin；The oblique groove is in the arrangement of falling herringbone, and corresponding with the oblique groove is convex Rib is also in the arrangement of falling herringbone；The bottom of the vessel is provided with helical groove, and container is close in one end of the helical groove The madial wall arrangement of body, the other end extends to outlet.
8. the pregnant woman and wet nurse of a kind of instant as claimed in claim 1 use nutritious supplementary pharmaceutical product, it is characterised in that institute 90 DEG C -150 DEG C of high temperature resistant is stated, the exotic material is polythene PE, polypropylene PP, expandable polystyrene EPS, PEN/ PET polyethylene naphtalates, the ethylene-vinyl alcohol copolymer EVOH containing high barrier material, Vingon PVDC, nylon It is one or more of in MXD6, Si oxide evaporation film.
9. the pregnant woman and wet nurse of a kind of instant are with the preparation method of nutritious supplementary pharmaceutical product, it is characterised in that including following step Suddenly：
(1) prepared without fishy smell, without ANFs good protein powder：
(2) prepared by core nutrient premixed powder：
(3) prepared by selective nutrient premixed powder：
(4) step (1) protein powder and step (2) core nutrient and the selective nutrient mixing of step (3), obtain powder：
(5) pelletize：Step (4) powder mixes with auxiliary material, pelletized；
(6) it is filling：The pregnant woman prepared and wet nurse are loaded in high-temperature-resistant high-pressure-resistant container with nutritious supplementary pharmaceutical particle, sealing.
10. the pregnant woman and wet nurse of a kind of instant as claimed in claim 9 are with the preparation method of nutritious supplementary pharmaceutical product, its It is characterised by comprising the following steps：
(1) prepared without fishy smell, without ANFs good protein powder, using following any mode：
A. soyabean protein powder purchased in market has to comply with GB/T 22493-2008 requirements, and the addition of good protein powder can be according to excellent The content of protein component in matter protein powder raw material, calculates raw material dosage, the good protein powder raw material consumption=egg The content of protein component in white matter addition ÷ good protein powder raw materials, is eliminated in protein powder using heat treatment method Fishy smell, passivation ANFs, the heat treatment method are any as follows：
Normal pressure steam treatment：After soybean is pulverized and sieved, mixed with vapours rapidly, reach moistureIn 90-100 DEG C of normal heating processingRapid cooling, you can inactivate lipoxidase, finished product better flavor, Fishy smell in protein powder, passivation ANFs are eliminated, and improves the nutritive value of product；
High-pressure water vapor processing：It is after soybean is pulverized and sieved, into pressure cooker, 110-130 DEG C of temperature, 10-20 minute, pressure 80-110kPa, can eliminate fishy smell in protein powder, passivation ANFs；
Spray hot wind passivating technique：Temperature is 232-310 DEG C of the direct spray treatment soyabean protein powder of hot blast, can be by fat oxidation Enzyme and ANFs passivation；
Or the preparation process of B. soyabean protein powders includes：
1. dry type is heat-treated：After defatted soy flour addition distilled water, it is put into rotary kiln and carries out dry type heat treatment；
2. extract：Extracted, the soy meal after dry type heat treatment, carried after addition distilled water using vertical type multifunctional dynamic extraction pot Take, be stirred continuously it is lower boiled up to more than 6 hours, be subsequently cooled to room temperature and obtain liquid phase mixed liquor；
3. separation of solid and liquid：Filtered, or just poured into after cooling in sedimentator after liquid phase mixture is cooled down, nutritious group will be contained The liquid phase and residue divided are separated, and obtain filtrate or centrifuged supernatant；
4. decompose：Filtrate or centrifuged supernatant are boiled, to promote the dissolving of the useful soluble component of soybean；And it is continuous Stirring is until filtrate becomes muddy and produces precipitation, and boiling time should be untill no longer producing precipitation；
5. separation of solid and liquid：Using centrifugal process, filtration method or dehydrator, the granule in suspended liquid is obtained containing soluble component Filtrate；
6. it is spray-dried：Filtrate containing soluble component is subject to 190-200 DEG C of spray drying EAT, 85 DEG C of temperature of outgoing air, Obtain the water-soluble soybean protein powder without fishy smell, without ANFs.
(2) prepared by core nutrient premixed powder：Core nutrient is commercially available, can be calculated according to the active constituent content of raw material Certain core nutrient effectively contains in raw material dosage, the core nutrient raw material dosage=certain core nutrient addition ÷ raw material Amount；
(3) prepared by selective nutrient premixed powder：According to the active constituent content of raw material, raw material dosage is calculated, from the market The suitable raw material of selection simultaneously determines its active constituent content, presses the conversion of column count formula：Raw material dosage=certain nutrient addition Certain nutrient effective content in ÷ raw materials；
(4) step (1) protein powder and step (2) core nutrient and the selective nutrient mixing of step (3), obtain powder：
(5) pelletize：Pelletized using dry or wet, addition auxiliary material, the nutritional ingredient of other special requirements and appropriate flavouring, Aromatic；The weight ratio of the auxiliary material and powder is 1-5:1, the auxiliary material is included in sucrose, lactose glucose, starch, fiber Element；
(6) it is filling：On the production line with nontoxic inert gas shielding, pregnant woman and breast are quantitatively tamped using Machine automated Mother uses nutritious supplementary pharmaceutical particle, and closure passes through the modes such as heat seal and container combination, it is ensured that be filled with sealing, container nontoxic The inert gas such as nitrogen or carbon dioxide.
CN201710437705.3A 2017-06-12 2017-06-12 The pregnant woman and wet nurse of a kind of instant are with nutritious supplementary pharmaceutical product and preparation method thereof Pending CN107242576A (en)

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CN107594540A (en) * 2017-11-05 2018-01-19 耿德铨 Help and breed nutriment composite powder and preparation method thereof
CN107890115A (en) * 2017-11-01 2018-04-10 苏州大学 A kind of nutrient powder for promoting the stagnant long fetal growth of gestational diabetes and preparation method and application
CN109288067A (en) * 2018-10-18 2019-02-01 德瑞美医药生物技术盐城有限公司 It is a kind of to help the pregnant nutritional preparation prevented miscarriage
CN110122885A (en) * 2019-06-06 2019-08-16 南通光合生物技术有限公司 The albumen powder of the easy brew of rapid dispersion
CN114651988A (en) * 2022-03-23 2022-06-24 浙江科露宝食品有限公司 Protein component formula food for special medical application and preparation method thereof

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107890115A (en) * 2017-11-01 2018-04-10 苏州大学 A kind of nutrient powder for promoting the stagnant long fetal growth of gestational diabetes and preparation method and application
CN107594540A (en) * 2017-11-05 2018-01-19 耿德铨 Help and breed nutriment composite powder and preparation method thereof
CN109288067A (en) * 2018-10-18 2019-02-01 德瑞美医药生物技术盐城有限公司 It is a kind of to help the pregnant nutritional preparation prevented miscarriage
CN110122885A (en) * 2019-06-06 2019-08-16 南通光合生物技术有限公司 The albumen powder of the easy brew of rapid dispersion
CN114651988A (en) * 2022-03-23 2022-06-24 浙江科露宝食品有限公司 Protein component formula food for special medical application and preparation method thereof

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