CN107233614A - A kind of promoting healing type first aid styptic powder and preparation method thereof - Google Patents
A kind of promoting healing type first aid styptic powder and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical drugses preparing technical field, and in particular to a kind of promoting healing type first aid styptic powder and preparation method thereof.The present invention prepares mushy hydroxyapatite powder by pig bone powder, the moisture in blood can be absorbed rapidly due to hydroxyapatite multi-pore structure, make blood rapid dehydration, form transient gel effect, and then quickly form gel, the clad of enzymolysis protein peptide formation simultaneously is effectively coated and covered to wound location, with internal hydroxyl groups apatite formation particle synergy, form the network structure of crosslinking, effectively improve the intensity of blood clot, effectively cooperateed with deer antler extract by Notogineng Extract again, promote capillary regeneration through Notogineng Extract, improve local microcirculation, deer antler extract rich protein glycan simultaneously repairs damage peripheral cell, promote cytothesis, reduce restoring area pain, the polypeptide formed simultaneously with enzymolysis is combined, effectively facilitate wound healing.
Description
Technical field
The invention belongs to medical drugses preparing technical field, and in particular to a kind of promoting healing type first aid styptic powder and its preparation
Method.
Background technology
The traumatic treatment principle lost blood, is fast and effectively to stop blooding first, next to that instant blood volume supply, most
It is the treatment to traumatic complication of losing blood afterwards.Wherein fast and effectively hemostasis is that treatment traumatic hemorrhage is particularly uncontrollable
Massive haemorrhage is also primarily topmost principle, if losing blood fast and effectively to be controlled, then the supplement of blood volume
It will be completely unnecessary, while many complication that blood transfusion etc. is brought can also be reduced.It is now recognized that relatively effective stop
Blood measure is still gauze filling, pressure dressing and using tourniquet etc., but can be physically with the pressurization of bandage
Block a part of traumatic hemorrhage, it does not have clotting factor, the easy adhesion surface of a wound, for amount of bleeding speed, amount of bleeding compared with
There is its limitation in big situation, this method.With reference to the characteristics of wound hemostasis, preferable hemostatic material feature should have with
Lower feature：1. can quickly, efficiently control various arteriovenous bleedings and extensive soft tissue injury bleeding；2. have
Certain plasticity, it is adaptable to body surface and it is deep variously-shaped surface of a wound bleeding；3. operation should simplicity, and have and can weigh as far as possible
Renaturation, general staff, which slightly trains, skillfully to be grasped；4. also can retention properties stabilization, Ke Yichang under harsh condition of battlefield
Phase stores；5. price economy, it is easy to equipment extensively；6. non-evident effect, further damage is not resulted in wound tissue.
7. preferably while with analgesic, a variety of functions such as anti-infective to adapt to the remediation environment that battlefield is simple and crude.
The external wider model of research range in terms of hemostatic material, it is also more deep, focus primarily upon Fibrin Glue, glue
Former albumen, chitin class, carboxymethyl cellulose class, a-cyanoacrylate class, alginic acid salt, many microporous minerals
Class etc., solidification of the main local blood that stopped blooding, accelerated by adding water-absorbing material etc. is just when in use for these materials
Method, but during to acute bleeding speed, haemostatic effect is poor, and can quick-acting haemostatic powder zeolitic materials due to anthemorrhagic speed
It hurry up, but its hemostasis can discharge amount of heat, easily cause and form blood clotting bulk strength not after tissue local fire damage, and hemostasis
Enough, blood clot, which is easily broken, increases the probability of secondary bleeding, while hemostatic material is wrapped only by clot is condensed to wound
Cover, it is impossible to improve wound healing speed, so according to the problem of above-mentioned material, preparing one kind can quickly have under urgent environment
It is the direction studied now that effect, which is stopped blooding and forms the preferable blood clot material of intensity,.
The content of the invention
Present invention mainly solves technical problem：Amount of heat can be discharged during for traditional styptic quick-acting haemostatic powder, and only
Blood clot insufficient strength is formed after blood, there is provided a kind of promoting healing type first aid styptic powder and its system for the problem of healing time is longer
Preparation Method.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
A kind of promoting healing type first aid styptic powder, including following parts by weight material：
65~75 portions of enzymolysis mixed liquors, 10~15 parts of calcining particles, 5~10 parts of cornstarch and 6~8 parts of chitosans, it is described
Calcining particle preparation process is：
In mass ratio 1:10, pig bone is mixed with acetone, after immersion treatment, degreasing pig bone is obtained, washs, dry, obtain dry pig bone,
Crush and ball milling sieves to obtain pig bone powder, pig bone powder is placed in tube-type atmosphere furnace, stood after calcining and be cooled to room temperature, must forged
Burn particle.
Described degreasing pig bone washing first uses 10% dioxygen water washing of mass fraction 3~5 times, then uses deionized water rinsing
3~5 times.
The described specific preparation process of enzymolysis mixed liquor is：
（1）In mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, 150 mesh sieves is crossed and obtains mixing and ball milling particle, by quality
Than 1:10, mixing and ball milling particle is mixed with deionized water, after heating water bath, filtered to get filtrate, rotary evaporation obtains concentrate；
（2）By volume 1:10, concentrate is mixed with absolute ethyl alcohol, still aging rear centrifuge collects supernatant liquor, obtains
Modification liquid, in mass ratio 1：5：10, collagen, the ammonium dibasic phosphate solution of mass fraction 1% and modification liquid are stirred and mixed, is obtained
Modified mixed liquor；
（3）In mass ratio 1:25, trypsase is added in modified mixed liquor, stirring mixes and adjusts pH to 8.0, and water-bath adds
It is hot to digest mixed liquor.
A kind of promoting healing type first aid styptic powder, preparation process is：Enzymolysis mixed liquor, calcining particle, corn is weighed respectively to form sediment
Powder and chitosan stirring mixing, ultrasonic disperse must disperse slurries, by scattered slurries mist projection granulating, you can be prepared into a kind of promoting healing
Type first aid styptic powder.
Described spray drying condition is to control inlet amount to be 60~75mL/min, adjusts drier centrifugal energy nozzle rotating speed
For 350~400r/min, intake air temperature is 75~80 DEG C, and air outlet temperature is 45~55 DEG C.
The beneficial effects of the invention are as follows：
（1）The present invention prepares mushy hydroxyapatite powder by pig bone powder, due to hydroxyapatite multi-pore structure
The moisture in blood can be absorbed rapidly, make blood rapid dehydration, and then red blood cell, blood platelet, fibrin is condensed rapidly
Around micropore, transient gel effect is formed, and then quickly forms gel, water suction exothermic effect will not be formed, it is stingless to wound
Swash performance；
（2）The clad of enzymolysis protein peptide formation simultaneously is effectively coated and covered to wound location, with internal hydroxyl groups phosphorus
Lime stone formation particle synergy, forms the network structure of crosslinking, effectively improves the intensity of blood clot, improve material blood coagulation clot
Haemostatic effect, make blood clot not cracky；
（3）The present invention is effectively cooperateed with by Notogineng Extract with deer antler extract, and capillary is promoted through Notogineng Extract
Regeneration, improves local microcirculation, and deer antler extract rich protein glycan simultaneously repairs damage peripheral cell, promotes cytothesis, drop
Low restoring area pain, while the polypeptide formed with enzymolysis is combined, is carried to the division of damaging cells peripheral cell and propagation
Support and divide, effectively facilitate wound healing.
Embodiment
In mass ratio 1:10, pig bone is mixed with acetone, at room temperature after 20~24h of immersion treatment, degreasing pig bone is taken out
And with 10% dioxygen water washing of mass fraction 3~5 times, then with deionized water rinsing 3~5 times, and vacuum freeze drying pig bone, will
Dry pig bone crushing to be placed in ball grinder, 3~5h of ball milling under 350~400r/min crosses 200 mesh sieves and obtains pig bone powder, will
Pig bone powder is placed in tube-type atmosphere furnace, and 6~8h is calcined at 550~600 DEG C, and standing is cooled to room temperature, and milling must calcine
Grain；Pilose antler and pseudo-ginseng blade are taken respectively, are dried after cleaning, in mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, mistake
150 mesh sieves obtain mixing and ball milling particle, in mass ratio 1:10, mixing and ball milling particle is mixed with deionized water, at 55~60 DEG C
After 2~3h of heating water bath, filter to get filtrate, rotation is evaporated to the 1/5 of original volume at 45~50 DEG C, concentrate is obtained, by volume
Than 1:10, concentrate is mixed with absolute ethyl alcohol, after still aging 6~8h, centrifuges and collects under 2500~3000r/min
Supernatant liquor, obtains modification liquid, then in mass ratio 1：5：10, by collagen, the ammonium dibasic phosphate solution of mass fraction 1% and modification
Liquid is mixed, and is stirred at room temperature after 25~30min, is prepared into modified mixed liquor, and then in mass ratio 1:25, trypsase is added
Add in modified mixed liquor, stirring mixes and the sodium bicarbonate solution of mass fraction 5% regulation pH to 8.0 is added dropwise, at 30~35 DEG C
45~60min of lower heating water bath, obtains enzymolysis mixed liquor；Count by weight, respectively weigh 65~75 parts enzymolysis mixed liquors, 10~
15 parts of calcining particles, 5~10 parts of cornstarch and 6~8 parts of chitosans are placed in beaker, and stirring is mixed and under 200~300W
10~15min of ultrasonic disperse, obtains scattered slurries, and then scattered slurries are placed in spray-drying installation, and it is 60 to control inlet amount
~75mL/min, regulation drier centrifugal energy nozzle rotating speed is 350~400r/min, is 75~80 DEG C, air-out in intake air temperature
Mouth temperature is mist projection granulating under the conditions of 45~55 DEG C, you can be prepared into a kind of promoting healing type first aid styptic powder.
Example 1
In mass ratio 1:10, pig bone is mixed with acetone, at room temperature after immersion treatment 20h, degreasing pig bone is taken out and uses quality
10% dioxygen water washing of fraction 3 times, then with deionized water rinsing 3 times, and vacuum freeze drying pig bone, pig bone will be dried and crushed simultaneously
It is placed in ball grinder, the ball milling 3h under 350r/min, crosses 200 mesh sieves and obtain pig bone powder, pig bone powder is placed in tube-type atmosphere furnace
In, 6h is calcined at 550 DEG C, standing is cooled to room temperature, calcining particle of milling to obtain；Pilose antler and pseudo-ginseng blade are taken respectively, after cleaning
Dry, in mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, 150 mesh sieves is crossed and obtains mixing and ball milling particle, in mass ratio
1:10, mixing and ball milling particle is mixed with deionized water, at 55 DEG C after heating water bath 2h, filtered to get filtrate, in 45 DEG C of backspins
Turn to be evaporated to the 1/5 of original volume, obtain concentrate, by volume 1:10, concentrate is mixed with absolute ethyl alcohol, still aging 6h
Afterwards, centrifuged under 2500r/min and collect supernatant liquor, obtain modification liquid, then in mass ratio 1：5：10, by collagen, matter
The ammonium dibasic phosphate solution of fraction 1% and modification liquid mixing are measured, is stirred at room temperature after 25min, is prepared into modified mixed liquor, then
In mass ratio 1:25, trypsase is added in modified mixed liquor, stirring is mixed and that the sodium acid carbonate of mass fraction 5% is added dropwise is molten
Liquid adjusts pH to 8.0, the heating water bath 45min at 30 DEG C, obtains enzymolysis mixed liquor；Count by weight, 65 parts of enzymes are weighed respectively
Solution mixed liquor, 10 parts of calcining particles, 5 parts of cornstarch and 6 parts of chitosans are placed in beaker, and stirring mixing is simultaneously ultrasonic under 200W
Scattered 10min, obtains scattered slurries, then scattered slurries is placed in spray-drying installation, and it is 60mL/min to control inlet amount, is adjusted
It is 350r/min to save drier centrifugal energy nozzle rotating speed, is 75 DEG C in intake air temperature, and air outlet temperature is spraying under the conditions of 45 DEG C
Granulation, you can be prepared into a kind of promoting healing type first aid styptic powder.
Example 2
In mass ratio 1:10, pig bone is mixed with acetone, at room temperature after immersion treatment 22h, degreasing pig bone is taken out and uses quality
10% dioxygen water washing of fraction 4 times, then with deionized water rinsing 4 times, and vacuum freeze drying pig bone, pig bone will be dried and crushed simultaneously
It is placed in ball grinder, the ball milling 4h under 375r/min, crosses 200 mesh sieves and obtain pig bone powder, pig bone powder is placed in tube-type atmosphere furnace
In, 7h is calcined at 575 DEG C, standing is cooled to room temperature, calcining particle of milling to obtain；Pilose antler and pseudo-ginseng blade are taken respectively, after cleaning
Dry, in mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, 150 mesh sieves is crossed and obtains mixing and ball milling particle, in mass ratio
1:10, mixing and ball milling particle is mixed with deionized water, at 57 DEG C after heating water bath 3h, filtered to get filtrate, in 47 DEG C of backspins
Turn to be evaporated to the 1/5 of original volume, obtain concentrate, by volume 1:10, concentrate is mixed with absolute ethyl alcohol, still aging 7h
Afterwards, centrifuged under 2750r/min and collect supernatant liquor, obtain modification liquid, then in mass ratio 1：5：10, by collagen, matter
The ammonium dibasic phosphate solution of fraction 1% and modification liquid mixing are measured, is stirred at room temperature after 27min, is prepared into modified mixed liquor, then
In mass ratio 1:25, trypsase is added in modified mixed liquor, stirring is mixed and that the sodium acid carbonate of mass fraction 5% is added dropwise is molten
Liquid adjusts pH to 8.0, the heating water bath 47min at 32 DEG C, obtains enzymolysis mixed liquor；Count by weight, 67 parts of enzymes are weighed respectively
Solution mixed liquor, 12 parts of calcining particles, 7 parts of cornstarch and 7 parts of chitosans are placed in beaker, and stirring mixing is simultaneously ultrasonic under 250W
Scattered 12min, obtains scattered slurries, then scattered slurries is placed in spray-drying installation, and it is 67mL/min to control inlet amount, is adjusted
It is 375r/min to save drier centrifugal energy nozzle rotating speed, is 77 DEG C in intake air temperature, and air outlet temperature is spraying under the conditions of 47 DEG C
Granulation, you can be prepared into a kind of promoting healing type first aid styptic powder.
Example 3
In mass ratio 1:10, pig bone is mixed with acetone, at room temperature after immersion treatment 24h, degreasing pig bone is taken out and uses quality
10% dioxygen water washing of fraction 5 times, then with deionized water rinsing 5 times, and vacuum freeze drying pig bone, pig bone will be dried and crushed simultaneously
It is placed in ball grinder, the ball milling 5h under 400r/min, crosses 200 mesh sieves and obtain pig bone powder, pig bone powder is placed in tube-type atmosphere furnace
In, 8h is calcined at 600 DEG C, standing is cooled to room temperature, calcining particle of milling to obtain；Pilose antler and pseudo-ginseng blade are taken respectively, after cleaning
Dry, in mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, 150 mesh sieves is crossed and obtains mixing and ball milling particle, in mass ratio
1:10, mixing and ball milling particle is mixed with deionized water, at 60 DEG C after heating water bath 3h, filtered to get filtrate, in 50 DEG C of backspins
Turn to be evaporated to the 1/5 of original volume, obtain concentrate, by volume 1:10, concentrate is mixed with absolute ethyl alcohol, still aging 8h
Afterwards, centrifuged under 3000r/min and collect supernatant liquor, obtain modification liquid, then in mass ratio 1：5：10, by collagen, matter
The ammonium dibasic phosphate solution of fraction 1% and modification liquid mixing are measured, is stirred at room temperature after 30min, is prepared into modified mixed liquor, then
In mass ratio 1:25, trypsase is added in modified mixed liquor, stirring is mixed and that the sodium acid carbonate of mass fraction 5% is added dropwise is molten
Liquid adjusts pH to 8.0, the heating water bath 60min at 35 DEG C, obtains enzymolysis mixed liquor；Count by weight, 75 parts of enzymes are weighed respectively
Solution mixed liquor, 15 parts of calcining particles, 10 parts of cornstarch and 8 parts of chitosans are placed in beaker, and stirring mixing simultaneously surpasses under 300W
Sound disperses 15min, obtains scattered slurries, and then scattered slurries are placed in spray-drying installation, and it is 75mL/min to control inlet amount,
It is 400r/min to adjust drier centrifugal energy nozzle rotating speed, is 80 DEG C in intake air temperature, and air outlet temperature is spray under the conditions of 55 DEG C
Mist is granulated, you can be prepared into a kind of promoting healing type first aid styptic powder.
The styptic powder prepared with present example 1,2,3 and the safe styptic powder of Ali Si of Medafor companies of U.S. production are
Reference group carries out performance comparison.
The three groups of styptic powders and each 10mg of reference group styptic powder for taking the present invention to prepare respectively, are placed in 5mL test tube, by powder
End is spread out in test tube bottom, the disodium citrate solution of every group of drop of addition 3 3.8% as far as possible.Take rat eyelet to take blood, add respectively
Enter 1mL blood in above-mentioned test tube, add 25 μ L 0.2mol/LCaCl2Solution is used for being complexed the anti-coagulants added before, and
Mix immediately, from addition CaCl2Start timing after solution.1min is first stood, test tube is tilted every 30s, can not to blood pool
Flowing, then stop timing, records each group clotting time
Contrast such as table 1 below.
The styptic powder performance table of comparisons of table 1
Compareed from upper table, the styptic powder prepared of the invention has excellent hemostasis speed, the blood coagulation clot of formation has excellent
Different anti-shedding strength.
Claims (5)
1. a kind of promoting healing type first aid styptic powder, it is characterised in that including following parts by weight material：
65~75 portions of enzymolysis mixed liquors, 10~15 parts of calcining particles, 5~10 parts of cornstarch and 6~8 parts of chitosans, it is described
Calcining particle preparation process is：
In mass ratio 1:10, pig bone is mixed with acetone, after immersion treatment, degreasing pig bone is obtained, washs, dry, obtain dry pig bone,
Crush and ball milling sieves to obtain pig bone powder, pig bone powder is placed in tube-type atmosphere furnace, stood after calcining and be cooled to room temperature, must forged
Burn particle.
2. a kind of promoting healing type first aid styptic powder according to claim 1, it is characterised in that：Described degreasing pig bone washing
First using 10% dioxygen water washing of mass fraction 3~5 times, then with deionized water rinsing 3~5 times.
3. a kind of promoting healing type first aid styptic powder according to claim 1, it is characterised in that：Described enzymolysis mixed liquor tool
Preparation step is：
（1）In mass ratio 1:5, pseudo-ginseng blade is mixed and ground with pilose antler, 150 mesh sieves is crossed and obtains mixing and ball milling particle, by quality
Than 1:10, mixing and ball milling particle is mixed with deionized water, after heating water bath, filtered to get filtrate, rotary evaporation obtains concentrate；
（2）By volume 1:10, concentrate is mixed with absolute ethyl alcohol, still aging rear centrifuge collects supernatant liquor, obtains
Modification liquid, in mass ratio 1：5：10, collagen, the ammonium dibasic phosphate solution of mass fraction 1% and modification liquid are stirred and mixed, is obtained
Modified mixed liquor；
（3）In mass ratio 1:25, trypsase is added in modified mixed liquor, stirring mixes and adjusts pH to 8.0, and water-bath adds
It is hot to digest mixed liquor.
4. a kind of promoting healing type first aid styptic powder, it is characterised in that preparation process is：Enzymolysis mixed liquor, calcining are weighed respectively
Grain, cornstarch and chitosan stirring mixing, ultrasonic disperse must disperse slurries, by scattered slurries mist projection granulating, you can be prepared into
A kind of promoting healing type first aid styptic powder.
5. a kind of promoting healing type first aid styptic powder according to claim 4, it is characterised in that：Described spray drying condition
For it is 60~75mL/min to control inlet amount, and regulation drier centrifugal energy nozzle rotating speed is 350~400r/min, intake air temperature
For 75~80 DEG C, air outlet temperature is 45~55 DEG C.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498841A (en) * | 2018-04-20 | 2018-09-07 | 苏州睿烁环境科技有限公司 | A kind of antibacterial anti hemorrhagic material and preparation method thereof that using effect is good |
| CN111249518A (en) * | 2018-12-01 | 2020-06-09 | 浙江大学 | Hemostatic composition and preparation method thereof |
| CN111249516A (en) * | 2018-12-01 | 2020-06-09 | 浙江大学 | Trypsin-containing hemostatic fabric and preparation method thereof |
| CN111450306A (en) * | 2020-03-06 | 2020-07-28 | 大连理工大学 | External nano hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof |
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| CN111249516B (en) * | 2018-12-01 | 2020-12-22 | 浙江大学 | Trypsin-containing hemostatic fabric and preparation method thereof |
| CN111249518B (en) * | 2018-12-01 | 2021-03-05 | 浙江大学 | Hemostatic composition and preparation method thereof |
| US11951228B2 (en) | 2018-12-01 | 2024-04-09 | Zhejiang University | Hemostatic composition and preparation method therefor |
| CN111450306A (en) * | 2020-03-06 | 2020-07-28 | 大连理工大学 | External nano hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof |
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