CN107233381A - A kind of milking sow galactopoietic and preparation method thereof - Google Patents
A kind of milking sow galactopoietic and preparation method thereof Download PDFInfo
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of milking sow galactopoietic and preparation method thereof, the galactopoietic is by pangolin, Radix Angelicae Sinensis, the root of Dahurain angelica, the Radix Astragali, pig nail and luffa seed composition.The galactopoietic uses ultrafiltration method in preparing, it is to avoid have the ingredients from lossing of immunization, natural component retains complete.The medicinal herb componentses included in the galactopoietic, conveniently and effectively realize the lactagogue of milking sow.On the one hand the problem of solving recovery and the health that there is side effect using chemical addition agent in modern plant and influence sow postpartum body.On the other hand the problem of being wasted time and energy greatly using physics lactagogue mode intensity is solved.
Description
Technical field
The present invention relates to herbal medicine technical field of traditional Chinese medicine preparation, more particularly to a kind of milking sow galactopoietic and its preparation side
Method.
Background technology
In Pig Industry industry, because being influenceed in various degree by various factors, often there is sow body condition excessively in production
Obesity, overnutrition upsets the phenomenon of organism endocrine, influences the lactation amount in its postpartum；Sow Postpartum constitution is weak, resists disease
Sick ability reduction, both influences lactation, also the reproduction in later stage is hidden some dangers for.Because the breast milk supply of sow after farrowing is universal not
Foot, some newborn piglets cause slow-growing or even death due to malnutritive, hypoimmunity.Therefore, sufficient sow milk
The milk water quality that water is become reconciled is to improve the key of pigling immunity, particularly colostrum, is had in piglet nutrition and on being immunized important
Effect.
Oneself develops warp the trend of current pig-breeding towards scale and intensive direction, but sow milk is not enough, milk
Not high water quality is always the bottleneck for perplexing pig industry development.At this stage main solution be using chemical addition agent method,
Massaged to sow feeding lactagogue food and to sow.Chemical addition agent lactagogue speed is fast, but with certain side effect,
Influence recovery and the health of sow postpartum body.To sow feeding lactagogue food and massage is carried out to sow to urge so as to play physics
The effect of breast, used physics lactagogue mode is all by manually carrying out at present, and not only intensity is big, and poultry raiser needs daily
Take much time progress lactagogue operation, wastes time and energy.
Cyclic nucleotide is the small molecule Auto-regulator being widely present in animal body, and it is by changing protein kinase activity and base
Hormone is mediated because of regulation and control, mediator etc. carries out a variety of triumpies to cell and regulated and controled.Department of animal husbandry of Northwest Agricultural University is in Chinese milk cow
" cyclic nucleotide and the lactation " delivered, has inquired into the relation in terms of the production performances such as cyclic nucleotide and galactopoiesis and metaboilic level.
It is demonstrated experimentally that positive correlation is presented using external source cyclic nucleotide and the output of milk.But it is due to technology and price problem, fails
Large-scale popularization is used in production.
Therefore, based on above-mentioned prior art, the present invention uses a kind of milking sow galactopoietic, and the galactopoietic is without pair
Effect, easy to use, lactagogue cost are low, large-scale popularization can use in production.
The content of the invention
In view of the deficienciess of the prior art, the invention provides a kind of milking sow galactopoietic and preparation method thereof, should
Comprising medicinal herb componentses such as pangolin, the Radix Astragali, Radix Angelicae Sinensis in galactopoietic, the lactagogue of milking sow is conveniently and effectively realized.On the one hand
Solve and there is side effect using chemical addition agent in modern plant and influence the recovery of sow postpartum body and healthy to ask
Topic.On the other hand the problem of being wasted time and energy greatly using physics lactagogue mode intensity is solved.
To achieve these goals, the present invention is to realize by the following technical solutions：
The invention provides a kind of milking sow galactopoietic, it is characterised in that the galactopoietic be by pangolin, Radix Angelicae Sinensis, the root of Dahurain angelica,
The Radix Astragali, pig nail and luffa seed composition.The galactopoietic is made up of the Chinese medicine of following portions by weight：Pangolin 60 ~ 100
Part, 80 ~ 120 parts of Radix Angelicae Sinensis, 45 ~ 70 parts of the root of Dahurain angelica, 60 ~ 100 parts of the Radix Astragali, 5 ~ 30 parts of pig nail, 45 ~ 60 parts of luffa seed.
Optimum ratio is：80 parts of pangolin, 100 parts of Radix Angelicae Sinensis, 50 parts of the root of Dahurain angelica, 80 parts of the Radix Astragali, 20 parts of pig nail and luffa seed
50 parts.
Contain Radix Angelicae Sinensis and the Radix Astragali in Chinese medicine of the present invention, Radix Angelicae Sinensis, the Radix Astragali contain cyclic nucleotide, and cyclic nucleotide is
The small molecule Auto-regulator being widely present in object, it mediates hormone by changing protein kinase activity and gene regulation, passed
Matter etc. carries out a variety of triumpies to cell and regulated and controled.Research shows that positive correlation is presented with the output of milk in cyclic nucleotide.Therefore, it is of the invention
Middle addition Radix Angelicae Sinensis, the Radix Astragali can adjust milking sow hormone secretion, promote sow lactation.
Contain pangolin and pig nail in Chinese medicine of the present invention.Pangolin, Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》Middle note
Carry and be：" modern times wind malaria, sore section, dysmenorrhoea, lower breast, with for key medicine ".Pig nail, is recorded in earliest《Sheng Nong's herbal classic》, it is used for
Lactagogue has long history；Wherein exist《Classified Materia Meidca》Described in " main hinder Da is all to lose sore, lower milk ".Forefathers facts have proved the two
Play the role of lower newborn.And in modern medicine, research shows, galactopoiesis galactosis at initial stage it is whether good with by PRL values after breast
Reactivity rise Chengdu have substantial connection.Pangolin and pig nail PRL can be adjusted under body hypogalactia situation, and then
Promote galactopoiesis.
Contain the root of Dahurain angelica in Chinese medicine of the present invention, the root of Dahurain angelica is first recorded in the Eastern Han Dynasty《Sheng Nong's herbal classic》, in vain, fragrance is arranged name
For middle product.It is pungent, it is warm-natured, cure mainly that " woman's whitish metrorrhagia, blood closes swelling of vulva, fever and chills, and public attention invades mesh lacrimation, and long skin is moistened, can
Make face fat ".It is generally used for expelling wind and clearing away cold, sensible analgesic, apocenosis of invigorating blood circulation, myogenic pain relieving, eliminating dampness stops band in the modern times.In the present invention
In, for improving milking sow resistance, enhance metabolism.
Contain luffa seed, Yao Kecheng in Chinese medicine of the present invention《Food book on Chinese herbal medicine》Record " bitter person：Main flood, appearance
Four limbs edema, lower water, makes us telling.Sweet tea person：Relieving restlessness is quenched the thirst, and controls heart heat, and dredging water passages, aligning lung controls urolithiasis, vomiting of ascaris worm ".In this hair
In bright, luffa seed is used to remove hot aligning lung, improves the resistance of milking sow, enhances metabolism.
Milking sow galactopoietic of the present invention takes full advantage of the property of medicine of Chinese herbal medicine, using Radix Angelicae Sinensis, the Radix Astragali, pangolin and
Pig nail promotes sow lactation；And the immunocompetence for the sow that enhances metabolism, improves using the root of Dahurain angelica and luffa seed.
A kind of preparation method of milking sow galactopoietic, it is characterised in that step is as follows：
（1）Prepare Chinese medicine extract：Pangolin, Radix Angelicae Sinensis, the root of Dahurain angelica, the Radix Astragali, pig nail and luffa seed are taken, crushes, is positioned over decoction
In container, the water logging for adding submergence amount there is not medicinal material, soaks, and is heated to boiling, continues to boil 1 hour, separates fried liquid.The dregs of a decoction according to
The above method is repeated fried 2 times, collects fried liquid；Again by centrifuging, filtering, Chinese medicine extract is obtained；
（2）It is concentrated in vacuo, is freeze-dried：After Chinese medicine extract in step 1 is concentrated in vacuo, in -5 DEG C of cryogenic freezings, constantly
Stirring makes to bear ice cube as particulate, using centrifuge except deicing considers the medicinal extract concentrated to be worth doing；
（3）Granulation：By step（2）Excipient is added in the medicinal extract of preparation, is mixed, heated-air drying removes moisture at 80 DEG C, plus
Enter 90% ethanol, softwood be made, wet grain is made with high speed centrifugation shredding machine, then dried with drying machine, granule is made.
Further, step（1）Middle filtering uses miillpore filter, pressure filtration.Avoid with many of immunoregulation effect
The loss of sugar and peptide constituents, natural component retains complete, is both played the characteristic of traditional Chinese herbal decoction, while reducing agent
Amount, obtained granular mass is high, and stability is good.
Further, step（3）The excipient is microcrystalline cellulose.Microcrystalline cellulose is a kind of spongy figuration of tool
Agent, though guiding humid medium it is slightly excessive also do not interfere with wet feed mix and stir sieving, remain to obtain more uniform particle, do not lump existing
As the advantages of.
The beneficial effect of technical scheme provided in an embodiment of the present invention：
1st, galactopoietic of the present invention uses Chinese herbal medicine, has no toxic side effect, and can enhance metabolism, improve milking sow postpartum
Immunocompetence.Solve and there is side effect using chemical addition agent in modern plant and influence the recovery of sow postpartum body
And the problem of health.
2nd, galactopoietic of the present invention is mingled in feed using can reach effect, is solved and is used physics lactagogue mode intensity
The problem of wasting time and energy greatly.
3rd, the preparation method of galactopoietic of the present invention avoids the loss of polysaccharide and peptide constituents with immunoregulation effect,
Natural component retains complete, is both played the characteristic of traditional Chinese herbal decoction, while dosage is reduced, worth granular mass
Height, stability is good.
Embodiment
To make technical scheme and main points clearer, further detailed is made to embodiment of the present invention below
Description.
The following examples are only intended to illustrate the technical solution of the present invention more clearly, therefore is only used as example, and can not
Limited the scope of the invention with this.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.
In order to prove lactagogue effect of the present invention to sow, company carries out test of many times on each pig farm, and experiment is using contrast
Experimental design, subjects are body weight size out of heat or bad heat, the basically identical lactation mother 30, every group of health status
10, the Chinese medicine preparation prepared by the feeding embodiment of the present invention 2 of test group 1, test group 2 is fed prepared by the embodiment of the present invention 3
Chinese medicine preparation, feeding method：The granule of preparation is added to free choice feeding in feed, feeding time with 3% ratio：7 days,
The conventional female pig's mixed feed of control group fed, result of the test see the table below：
A kind of preparation method of milking sow galactopoietic of embodiment 1, it is characterised in that step is as follows：
（1）Prepare Chinese medicine extract：Take 100 parts of pangolin, 80 parts of Radix Angelicae Sinensis, 70 parts of the root of Dahurain angelica, 60 parts of the Radix Astragali, 5 parts of pig nail and thread
60 parts of melon seeds, are crushed, and are positioned in decoction container, the water logging for adding submergence amount there is not medicinal material, are soaked, are heated to boiling, continue to boil 1
Hour, separate fried liquid.The dregs of a decoction are repeated fried 2 times according to the above method, collect fried liquid；Again by centrifugation, micropore filter
Film pressure filtration, obtains Chinese medicine extract；
（2）It is concentrated in vacuo, is freeze-dried：After Chinese medicine extract in step 1 is concentrated in vacuo, in -5 DEG C of cryogenic freezings, constantly
Stirring makes to bear ice cube as particulate, using centrifuge except deicing considers the medicinal extract concentrated to be worth doing；
（3）Granulation：By step（2）Microcrystalline cellulose is added in the medicinal extract of preparation, is mixed, heated-air drying removes water at 80 DEG C
Point, the ethanol of addition 90% is made softwood, wet grain is made with high speed centrifugation shredding machine, then is dried with drying machine, and granule is made.
A kind of preparation method of milking sow galactopoietic of embodiment 2, it is characterised in that step is as follows：
（1）Prepare Chinese medicine extract：Take 80 parts of pangolin, 100 parts of Radix Angelicae Sinensis, 50 parts of the root of Dahurain angelica, 80 parts of the Radix Astragali, 20 parts of pig nail and thread
50 parts of melon seeds, are crushed, and are positioned in decoction container, the water logging for adding submergence amount there is not medicinal material, are soaked, are heated to boiling, continue to boil 1
Hour, separate fried liquid.The dregs of a decoction are repeated fried 2 times according to the above method, collect fried liquid；Again by centrifugation, micropore filter
Film pressure filtration, obtains Chinese medicine extract；
（2）It is concentrated in vacuo, is freeze-dried：After Chinese medicine extract in step 1 is concentrated in vacuo, in -5 DEG C of cryogenic freezings, constantly
Stirring makes to bear ice cube as particulate, using centrifuge except deicing considers the medicinal extract concentrated to be worth doing；
（3）Granulation：By step（2）Microcrystalline cellulose is added in the medicinal extract of preparation, is mixed, heated-air drying removes water at 80 DEG C
Point, the ethanol of addition 90% is made softwood, wet grain is made with high speed centrifugation shredding machine, then is dried with drying machine, and granule is made.
A kind of preparation method of milking sow galactopoietic of embodiment 3, it is characterised in that step is as follows：
（1）Prepare Chinese medicine extract：Take 60 parts of pangolin, 120 parts of Radix Angelicae Sinensis, 45 parts of the root of Dahurain angelica, 100 parts of the Radix Astragali, 30 parts of pig nail, silk
45 parts of melon seeds, are crushed, and are positioned in decoction container, the water logging for adding submergence amount there is not medicinal material, are soaked, are heated to boiling, continue to boil 1
Hour, separate fried liquid.The dregs of a decoction are repeated fried 2 times according to the above method, collect fried liquid；Again by centrifugation, micropore filter
Film pressure filtration, obtains Chinese medicine extract；
（2）It is concentrated in vacuo, is freeze-dried：After Chinese medicine extract in step 1 is concentrated in vacuo, in -5 DEG C of cryogenic freezings, constantly
Stirring makes to bear ice cube as particulate, using centrifuge except deicing considers the medicinal extract concentrated to be worth doing；
（3）Granulation：By step（2）Microcrystalline cellulose is added in the medicinal extract of preparation, is mixed, heated-air drying removes water at 80 DEG C
Point, the ethanol of addition 90% is made softwood, wet grain is made with high speed centrifugation shredding machine, then is dried with drying machine, and granule is made.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among the claim of the present invention and the scope of specification.
Claims (7)
1. a kind of milking sow galactopoietic, it is characterised in that the galactopoietic is by pangolin, Radix Angelicae Sinensis, the root of Dahurain angelica, the Radix Astragali, trotter
First and luffa seed composition.
2. milking sow galactopoietic according to claim 1, it is characterised in that the galactopoietic is by following portions by weight
Chinese medicine composition：
60 ~ 100 parts of pangolin, 80 ~ 120 parts of Radix Angelicae Sinensis, 45 ~ 70 parts of the root of Dahurain angelica, 60 ~ 100 parts of the Radix Astragali, 5 ~ 30 parts of pig nail, luffa seed
45 ~ 60g parts.
3. galactopoietic according to claim 2, it is characterised in that the parts by weight of the Chinese medicine are：80 parts of pangolin,
50 parts of 100 parts of Radix Angelicae Sinensis, 50 parts of the root of Dahurain angelica, 80 parts of the Radix Astragali, 20 parts of pig nail and luffa seed.
4. galactopoietic according to claim 2, it is characterised in that the parts by weight of the Chinese medicine are：96 parts of pangolin,
60 parts of 120 parts of Radix Angelicae Sinensis, 72 parts of the root of Dahurain angelica, 120 parts of the Radix Astragali, 10 parts of pig nail and luffa seed.
5. a kind of preparation method of milking sow galactopoietic, it is characterised in that step is as follows：
（1）Prepare Chinese medicine extract：Pangolin, Radix Angelicae Sinensis, the root of Dahurain angelica, the Radix Astragali, pig nail and luffa seed are taken, crushes, is positioned over decoction
In container, the water logging for adding submergence amount there is not medicinal material, after soaking 2 hours, is heated to boiling, continues to boil 1 hour, separates fried liquid；
The dregs of a decoction are repeated fried 2 times according to the above method, collect fried liquid；Again by centrifuging, filtering, traditional Chinese medicine extraction is obtained
Liquid；
（2）It is concentrated in vacuo, is freeze-dried：After Chinese medicine extract in step 1 is concentrated in vacuo, in -5 DEG C of cryogenic freezings, constantly
Stirring makes to bear ice cube as particulate, using centrifuge except deicing considers the medicinal extract concentrated to be worth doing；
（3）Granulation：By step（2）Excipient is added in the medicinal extract of preparation, is mixed, heated-air drying removes moisture at 80 DEG C, plus
Enter 90% ethanol, softwood be made, wet grain is made with high speed centrifugation shredding machine, then dried with drying machine, granule is made.
6. preparation method according to claim 5, it is characterised in that step（1）Middle filtering uses miillpore filter, pressurizes
Filter.
7. preparation method according to claim 5, it is characterised in that step（3）The excipient is microcrystalline cellulose.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248176A (en) * | 2018-10-24 | 2019-01-22 | 苏州卫生职业技术学院 | A kind of artificial pangolin compound powder |
| CN109463542A (en) * | 2018-11-29 | 2019-03-15 | 深圳农畉食品开发集团有限公司 | A kind of sow lactagogue forage and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554400A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Medicine for preventing and curing agalactia, lactation lack and mastitis of livestock and preparation method thereof |
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2017
- 2017-07-11 CN CN201710560438.9A patent/CN107233381A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554400A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Medicine for preventing and curing agalactia, lactation lack and mastitis of livestock and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| "少乳、催乳二十方", 《医学文选》 * |
| 贺文芳: "催乳食方知多少", 《中国食品》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248176A (en) * | 2018-10-24 | 2019-01-22 | 苏州卫生职业技术学院 | A kind of artificial pangolin compound powder |
| CN109463542A (en) * | 2018-11-29 | 2019-03-15 | 深圳农畉食品开发集团有限公司 | A kind of sow lactagogue forage and preparation method |
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