CN107233324A - A kind of azithromycin formulations and preparation method thereof - Google Patents
A kind of azithromycin formulations and preparation method thereof Download PDFInfo
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- CN107233324A CN107233324A CN201710440742.XA CN201710440742A CN107233324A CN 107233324 A CN107233324 A CN 107233324A CN 201710440742 A CN201710440742 A CN 201710440742A CN 107233324 A CN107233324 A CN 107233324A
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- azithromycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
Abstract
The present invention relates to azithromycin formulations and its preparing technical field, more particularly to a kind of azithromycin formulations and preparation method thereof, the azithromycin formulations are made up of the material of following parts by weight：5~15 parts of azithromycin, 5~18 parts of mouth feel modifying agents, 10~22 parts of edible glue, the mouth feel modifying agents include milk powder and/or honey；Azithromycin formulations are made to the tablet for having similar profile and same flavor with candy in the present invention, the elderly and children can be caused to the interest-degree of medicine, so as to reduce the trouble taken, pass through the addition of plant gel, accelerate the rate of release of medicine, be conducive to the absorption of medicine, so as to improve the curative effect of medicine.
Description
Technical field
The present invention relates to azithromycin formulations and its preparing technical field, more particularly to a kind of azithromycin formulations and its system
Preparation Method.
Background technology
Azithromycin is semi-synthetic 15 membered macrolide antibiotic, and its free alkali supplies oral, and Lactobionate supplies injection, than
Erythromycin has a broad antifungal spectrum, antibacterial activity is strong, simultaneously because the difference in structure, more stable to acid, with good clinical practice
Prospect, the treatment of respiratory tract, the Skin and soft tissue infection being mainly used in caused by sensitive microbial etc..Azithromycin by with
50s ribosomes time unit is combined, and the displacement of blocking peptide prevents the synthesis of bacterial peptide, except having similar antimicrobial spectrum to erythromycin
Outside, also there is stronger activity to some pathogenic bacteria insensitive to erythromycin, azithromycin has bigger antibiotic than erythromycin
Aftereffect, its effective antibacterial action at least can also maintain 10d after drug withdrawal, while there is cross resistance with asking for erythromycin.
There is powerful antibacterial activity to gram-negative cocci, bacillus, anaerobic bacteria and intracellular pathogenic bacteria and Mycoplasma, to the blue sun of leather
Property bacterium have stronger antibacterial activity.It is stronger than erythromycin to the effect of haemophilus influenzae, gonococcus 4 times, it is strong to Legionella 2 times, it is right
The μ gmL of MIC ＜ 1 of most gram-negative bacterias-1, the effect to clostruidium is also better than erythromycin, to mycoplasma,
Chlamydia is then suitable or stronger with erythromycin.Azithromycin is 1 μ gmL to the MIC90 of haemophilus influenzae-1, 4h interior energies are quick
99.9% haemophilus influenzae is killed, and the MIC90 of erythromycin is 4~8 μ gmL-1,6- neighbours erythromycin, Luo Xi are red mould
The activity of plain anti-current haemophilus influenza is lower than azithromycin 4~8 times.Azithromycin is high to the selective bactericidal action of pathogen
It is in internal bactericidal activity to pneumococcus, pneumobacillus, Bacillus influenzae and Escherichia coli etc., to table Portugal ball during tissue concentration
Bacterium, micrococcus scarlatinae, streptococcus pneumonia bactericidal action are relatively strong, and staphylococcus and most gram-negative bacterias are made without sterilization
With.Many pharmacy workers have done numerous studies to its oral formulations；But these preparations be not still be best suitable for children, it is old
The formulation kind of the bad patient medication features of function of deglutition such as year people, patient has certain difficulty using existing product, displeased
Receive, such as syrup, solution is perishable, taking dose is difficult to control, transport, storage are inconvenient；The dose of granule is big,
Auxiliary material without medical function is more；Capsule, tablet have the shortcomings that dysphagia；Injection is although rapid-action, but security is still
Have much room for improvement；And the poor dissolution in water of azithromycin, pH value 9-11, antibacterial activity is relevant with pH value, increases with pH and increases
By force, low pH causes azithromycin activity reduction in lysosome, so improving the key issue that bioavilability is also dosage form selection.
In view of old man children are poor to the ability to accept of general formulation in real life, outward appearance, the mouthfeel of medicine directly affect answering for medicine
With and curative effect, select suitable prescription control disease and the formulation suitably taken be research and development set about a little, develop a kind of city
Field has a extensive future, the bioavilability height that old man children are willing to accept, strong drug action, divided dose are accurate, be easy to the ideal taken new
Formulation is very necessary.
The content of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of azithromycin formulations, and said preparation mouthfeel is unique, good effect,
Be particularly suitable for use in the elderly and children taking.
A kind of azithromycin formulations, are made up of the material of following parts by weight：5~15 parts of azithromycin, mouth feel modifying agents 5~
18 parts, 10~22 parts of edible glue, wherein the mouth feel modifying agents include milk powder and/or honey.
It is preferred that, the azithromycin formulations are made up of the material of following parts by weight：8~12 parts of azithromycin, mouthfeel are adjusted
Save 6~10 parts of agent, 12~20 parts of edible glue.
According to the present invention, because children and old man are very sensitive to the mouthfeel of medicine, if medicine is bitter, puckery, him can be caused
Difficulty of taking medicine, in order to solve this problem, the present invention adds the mouthfeel of milk powder regulating drug, milk powder in azithromycin formulations
Medicine mouthfeel can not only be improved, and also contain substantial amounts of nutritional ingredient in milk, damage of the Western medicine to stomach can be reduced；
In order to improve the scope of application of medicine, it is to avoid the fat in milk powder causes shadow to special population (such as hypertension, people with hyperlipidemia)
Ring, it is preferred that the milk powder is skimmed milk power.
Honey flavour sweet tea, it is very popular, and there is the effect of nourishing the stomach in honey, sensitive group can be mitigated to medicine
The inadaptability of thing, in addition, people's resistance can be also strengthened containing abundant trace element in honey.
Edible glue can not only by azithromycin and other auxiliary materials bonding, it is agglomerated together, be also excellent forming agent, and food
It with substantial amounts of moisture is contained in glue, can form porous after the drying, increase the diffusion rate of medicine, it is preferred that present invention choosing
With harmless natural gum, the natural gum is natural plant gum and/or animal glue, and more specifically, the edible glue is Guar
Bean gum, locust bean gum, tamarind gum, flaxseed gum, Chinese honey locust bean gum, Arabic gum, bassora gum, ghatti gum, Karaya Gum, peach
Glue, pectin, konjac glucomannan, lndian aloe extract solution, synanthrin, celestial grass polysaccharide, gelatin, casein sodium, chitin, chitosan, fish
At least one of glue, agar, carragheen, alginic acid, propylene glycol alginate, furcellaran, brown alga salt algae glycan.
It is preferred that, the azithromycin formulations also include the material of following parts by weight：1~5 part of pore-foaming agent, filler 10
~25 parts, it is 1~3 part of lubricant, 3~12 parts of disintegrant, 0.05~0.58 part of preservative, 0.02~0.5 part of colouring agent, anti-oxidant
0.05~0.15 part of agent, 0.05~2 part of plasticizer, 5~50 parts of solvent.
It is preferred that, described pore-foaming agent is selected from polyethylene glycol, polyvinylpyrrolidone, lauryl sodium sulfate and hydroxypropyl
At least one of methylcellulose, pore-foaming agent has the characteristics of dissolubility is good, makes to dissolve rapidly after contact body fluid,
The drug release duct of insertion is formed in coatings.Polyethylene glycol is selected from as further preferred, described pore-foaming agent.Polyethylene glycol
Not only there is preferable dissolubility, while also having plasticization, it is possible to increase the plasticity of coatings, make to be not likely to produce crackle.
It is preferred that, in order to improve the inoxidizability of azithromycin agent, extend its storage time, it is preferred that the beauty is supported
Also contain antioxidant and/or preservative in the traditional Chinese medicine health care product of face, it is further preferred that the antioxidant is butylhydroxy
In anisole, dibutyl hydroxy toluene, propylgallate, tert-butylhydroquinone, tocopherol, vitamin E and ascorbic acid
At least one.
The preservative is benzoic acid, sodium benzoate, potassium sorbate, dehydroactic acid sodium, propylparaben, propionic acid
Calcium, sodium Diacetate, sodium lactate, streptococcus lactis, natamycin, hydrogen peroxide, sulfur dioxide, sulphite and nitrite etc.
At least one of.
Filler can dilute the concentration of medicine, and can also more accurate regulating drug concrete content in matrix,
Preferably, one kind in microcrystalline cellulose, lactose, starch, pre-paying starch, sucrose, dextrin of described filler or
It is several.It is one or more of in lactose, starch, microcrystalline cellulose as further preferred, described filler.As optimal
Choosing, described filler is lactose.Lactose is water-soluble, and the obtained label containing lisinopril can be made to have smooth and beautiful appearance
Effect, and have the bioavilability for utilizing and improving azithromycin.
It is preferred that, the pore-foaming agent is polyethylene glycol, polyvinylpyrrolidone, lauryl sodium sulfate and hydroxypropyl methyl
At least one of cellulose.
Colouring agent has strong color, it is possible to increase children are to the interest of medicine, so as to reduce the difficulty of children's medication
Degree, it is preferred that the colouring agent is that amaranth, beet red, red lac, red pigment of cowberry, capsanthin, red rice be red, carmine, red moss
At least one of red, newly red, lemon yellow, sunset yellow, indigo, light blue.
Also include plasticizer in described azithromycin system, described plasticizer can improve the Orally disintegrating of the present invention
The plasticity of piece, makes to be not likely to produce crackle.It is used as the one kind of further preferred, described plasticizer in glycerine, castor oil
Or two kinds.
Preferably, one or more of the described lubricant in magnesium stearate, talcum powder, superfine silica gel powder.Can
Play lubrication and help stream to act on.Magnesium stearate and superfine silica gel powder are selected from as further preferred, described lubricant.
A kind of preparation method of azithromycin formulations, comprises the following steps：
(1) edible glue is soaked in water and/or ethanol solution and be stirred continuously in 5~60min, immersion process, obtain molten
Glue；
(2) azithromycin powder and other auxiliary agents are added in the colloidal sol of step (1), milk powder is stirring evenly and then adding into, adjusted
Into drug slurries；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 30~50 DEG C 5~24 hours, that is, obtain Ah
Miramycin preparation.
Wherein, it is apt to deteriorate at high temperature due to containing the auxiliary materials such as milk powder and honey in above-mentioned azithromycin formulations, therefore
Medicine is dried from relatively low temperature, in order to improve drying efficiency, the drying is to be dried under reduced pressure.
Compared with prior art, the present invention has following technique effect：
Azithromycin formulations are made to the tablet for having similar profile and same flavor with candy, Neng Gouyin in the present invention
The elderly and children are played to the interest-degree of medicine, so as to reduce the trouble taken, by the addition of plant gel, are accelerated
The rate of release of medicine, is conducive to the absorption of medicine, so as to improve the curative effect of medicine.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
The invention provides a kind of azithromycin formulations, it is made up of the material of following parts by weight：10 parts of azithromycin, degreasing
8 parts of milk powder, 15 parts of guar gum, 3 parts of polyethylene glycol, 15 parts of starch, 2 parts of lubricant, 6 parts of sodium carboxymethyl starch, benzoic acid
0.30 part, 0.2 part of beet red, 0.10 part of butylated hydroxy anisole, 1 part of castor oil, 30 parts of water；
Present invention also offers the preparation method of the azithromycin formulations, comprise the following steps：
(1) guar gum is soaked in water and be stirred continuously in 30min, immersion process, obtain colloidal sol；
(2) in the colloidal sol of step (1) add azithromycin powder, skimmed milk power, guar gum, polyethylene glycol, starch,
Lubricant, sodium carboxymethyl starch, benzoic acid, beet red, butylated hydroxy anisole, castor oil, are stirring evenly and then adding into milk powder, adjust
Into drug slurries；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 40 DEG C 12 hours, that is, obtains azithromycin system
Agent.
Embodiment 2
The invention provides a kind of azithromycin formulations, it is made up of the material of following parts by weight：8 parts of azithromycin, honey 6
Part, 12 parts of flaxseed gum, 1 part of polyethylene glycol, 10 parts of starch, 1 part of talcum powder, 3 parts of sodium carboxymethyl starch, P-hydroxybenzoic acid third
0.05 part of ester, 0.02 part of sunset yellow, 0.05 part of propylgallate, 0.05 part of plasticizer, 5 parts of ethanol；
Present invention also offers the preparation method of the azithromycin formulations, comprise the following steps：
(1) flaxseed gum is soaked in ethanol solution and be stirred continuously in 5min, immersion process, obtain colloidal sol；
(2) azithromycin powder, honey, flaxseed gum, polyethylene glycol, starch, talcum are added in the colloidal sol of step (1)
Powder, sodium carboxymethyl starch, propylparaben, sunset yellow, propylgallate, plasticizer, are stirring evenly and then adding into milk
Powder, is tuned into drug slurries；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 30 DEG C 5 hours, that is, obtains azithromycin system
Agent.
Embodiment 3
The invention provides a kind of azithromycin formulations, it is made up of the material of following parts by weight：12 parts of azithromycin, degreasing
5 parts of milk powder, 5 parts of honey, 20 parts of guar gum, 5 parts of polyethylene glycol, 25 parts of starch, 3 parts of superfine silica gel powder, 12 parts of dried starch, propionic acid
0.58 part of calcium, 0.5 part of capsanthin, 0.15 part of dibutyl hydroxy toluene, 2 parts of glycerine, 25 parts of water, 25 parts of ethanol；
Present invention also offers the preparation method of the azithromycin formulations, comprise the following steps：
(1) guar gum is soaked in water and ethanol solution and be stirred continuously in 60min, immersion process, obtain colloidal sol；
(2) in the colloidal sol of step (1) add azithromycin powder, skimmed milk power, honey, guar gum, polyethylene glycol,
Starch, superfine silica gel powder, dried starch, calcium propionate, capsanthin, dibutyl hydroxy toluene, glycerine, are stirring evenly and then adding into milk powder, adjust
Into drug slurries；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 50 DEG C 24 hours, that is, obtains azithromycin system
Agent.
Embodiment 4
The invention provides a kind of azithromycin formulations, it is made up of the material of following parts by weight：5 parts of azithromycin, degreasing
5 parts of milk powder, 10 parts of Arabic gum, 2 parts of polyvinylpyrrolidone, 12 parts of calcium sulfate, 1.2 parts of magnesium stearate, low substituted hydroxy-propyl
4 parts of cellulose, 0.42 part of calcium propionate, indigo 0.34 part, 0.1 part of tert-butylhydroquinone, 1.4 parts of castor oil, 14 parts of ethanol；
Present invention also offers the preparation method of the azithromycin formulations, comprise the following steps：
(1) Arabic gum is soaked in water and/or ethanol solution and be stirred continuously in 50min, immersion process, obtain molten
Glue；
(2) azithromycin powder, skimmed milk power, Arabic gum, polyvinylpyrrolidine are added in the colloidal sol of step (1)
Ketone, calcium sulfate, magnesium stearate, low-substituted hydroxypropyl cellulose, calcium propionate, indigo, tert-butylhydroquinone, castor oil, stirring
Milk powder is added after uniform, drug slurries are tuned into；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 34 DEG C 20 hours, that is, obtains azithromycin system
Agent.
Embodiment 5
The invention provides a kind of azithromycin formulations, it is made up of the material of following parts by weight：It is 15 parts of azithromycin, full-cream
8 parts of milk powder, 10 parts of honey, 22 parts of celestial grass polysaccharide, 5 parts of lauryl sodium sulfate, 20 parts of microcrystalline cellulose, 2.3 parts of magnesium stearate,
10 parts of Ac-Di-Sol, 0.4 part of sodium Diacetate, carmine 0.4 part, 0.1 part of tocopherol, 2 parts of castor oil, aqueous solvent
10 parts, 25 parts of ethanol；
Present invention also offers the preparation method of the azithromycin formulations, comprise the following steps：
(1) celestial grass polysaccharide is soaked in water and ethanol solution and be stirred continuously in 40min, immersion process, obtain colloidal sol；
(2) azithromycin powder, whole milk powder, honey, 22 parts of celestial grass polysaccharide, 12 are added in the colloidal sol of step (1)
Sodium alkyl sulfate, microcrystalline cellulose, magnesium stearate, Ac-Di-Sol, sodium Diacetate, famille rose, tocopherol, castor-oil plant
Oil, is stirring evenly and then adding into milk powder, is tuned into drug slurries；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 35 DEG C 14 hours, that is, obtains azithromycin system
Agent.
Foregoing description is only the description to section Example of the present invention, not to any restriction of the scope of the invention, one's own profession
The those of ordinary skill of industry can make improvement according to the present invention or change to above-described embodiment, but belong to present invention protection model
Enclose.
Claims (10)
1. a kind of azithromycin formulations, it is characterised in that be made up of the material of following parts by weight：5~15 parts of azithromycin, mouthfeel
5~18 parts of conditioning agent, 10~22 parts of edible glue；
The mouth feel modifying agents include milk powder and/or honey.
2. azithromycin formulations according to claim 1, it is characterised in that be made up of the material of following parts by weight：Archie
8~12 parts of mycin, 6~10 parts of mouth feel modifying agents, 12~20 parts of edible glue.
3. azithromycin formulations according to claim 1, it is characterised in that the milk powder is skimmed milk power.
4. azithromycin formulations according to claim 3, it is characterised in that the edible glue be guar gum, locust bean gum,
Tamarind gum, flaxseed gum, Chinese honey locust bean gum, Arabic gum, bassora gum, ghatti gum, Karaya Gum, peach gum, pectin, konjaku
Glue, lndian aloe extract solution, synanthrin, celestial grass polysaccharide, gelatin, casein sodium, chitin, chitosan, fish glue, agar, OK a karaoke club
At least one of glue, alginic acid, propylene glycol alginate, furcellaran, brown alga salt algae glycan.
5. the azithromycin formulations according to Claims 1 to 4 any one, it is characterised in that also comprising following parts by weight
Material：1~5 part of pore-foaming agent, 10~25 parts of filler, 1~3 part of lubricant, 3~12 parts of disintegrant, preservative 0.05~
0.58 part, 0.02~0.5 part of colouring agent, 0.05~0.15 part of antioxidant, 0.05~2 part of plasticizer, 5~50 parts of solvent.
6. azithromycin formulations according to claim 5, it is characterised in that the pore-foaming agent is polyethylene glycol, polyethylene
At least one of pyrrolidones, lauryl sodium sulfate and hydroxypropyl methyl cellulose.
7. azithromycin formulations according to claim 5, it is characterised in that the preservative be benzoic acid, sodium benzoate,
Potassium sorbate, dehydroactic acid sodium, propylparaben, calcium propionate, sodium Diacetate, sodium lactate, streptococcus lactis, receive that he is mould
At least one of element, hydrogen peroxide, sulfur dioxide, sulphite and nitrite.
8. the azithromycin formulations according to claim 7 any one, it is characterised in that the antioxidant is butyl hydroxyl
Base anisole, dibutyl hydroxy toluene, propylgallate, tert-butylhydroquinone, tocopherol, vitamin E and ascorbic acid
At least one of.
9. azithromycin formulations according to claim 5, it is characterised in that the filler be starch, dextrin, sucrose,
At least one of lactose, mannitol, calcium sulfate, microcrystalline cellulose etc..
10. the preparation method of the azithromycin formulations according to claim 1~9 any one, it is characterised in that including with
Lower step：
(1) edible glue is soaked in water and/or ethanol solution and be stirred continuously in 5~60min, immersion process, obtain colloidal sol；
(2) azithromycin powder and other auxiliary agents are added in the colloidal sol of step (1), milk powder is stirring evenly and then adding into, is tuned into medicine
Thing slurry；
(3) slurry is pressed into tablet with tablet press machine, is then dried under reduced pressure at 30~50 DEG C 5~24 hours, that is, obtains Zitromax
Plain preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110169957A (en) * | 2019-05-17 | 2019-08-27 | 南京望知星医药科技有限公司 | A kind of Azithromycin composite and preparation method thereof |
| CN110693844A (en) * | 2019-11-18 | 2020-01-17 | 陕西省核工业二一五医院 | Biscuit type azithromycin preparation and preparation method thereof |
| CN112315924A (en) * | 2020-11-10 | 2021-02-05 | 迪沙药业集团有限公司 | Azithromycin composition and preparation method thereof |
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| CN1634112A (en) * | 2004-10-20 | 2005-07-06 | 贵阳云岩西创药物科技开发有限公司 | Azithromycin gel formulation and its preparing process |
| CN1742745A (en) * | 2005-09-20 | 2006-03-08 | 合肥恒星药物研究所 | Azithromycin gel |
| US20060198895A1 (en) * | 2005-03-07 | 2006-09-07 | Kotliar Eleonora M | Azithromycin powder for oral suspension compositions |
| CN101269085A (en) * | 2007-03-22 | 2008-09-24 | 刘凤鸣 | Oral preparation containing azithromycin, preparation method and application thereof |
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2017
- 2017-06-13 CN CN201710440742.XA patent/CN107233324A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1634112A (en) * | 2004-10-20 | 2005-07-06 | 贵阳云岩西创药物科技开发有限公司 | Azithromycin gel formulation and its preparing process |
| US20060198895A1 (en) * | 2005-03-07 | 2006-09-07 | Kotliar Eleonora M | Azithromycin powder for oral suspension compositions |
| CN1742745A (en) * | 2005-09-20 | 2006-03-08 | 合肥恒星药物研究所 | Azithromycin gel |
| CN101269085A (en) * | 2007-03-22 | 2008-09-24 | 刘凤鸣 | Oral preparation containing azithromycin, preparation method and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110169957A (en) * | 2019-05-17 | 2019-08-27 | 南京望知星医药科技有限公司 | A kind of Azithromycin composite and preparation method thereof |
| CN110693844A (en) * | 2019-11-18 | 2020-01-17 | 陕西省核工业二一五医院 | Biscuit type azithromycin preparation and preparation method thereof |
| CN112315924A (en) * | 2020-11-10 | 2021-02-05 | 迪沙药业集团有限公司 | Azithromycin composition and preparation method thereof |
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