CN107213172A - Asclerol oral liquid and preparation method thereof - Google Patents
Asclerol oral liquid and preparation method thereof Download PDFInfo
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- CN107213172A CN107213172A CN201710440889.9A CN201710440889A CN107213172A CN 107213172 A CN107213172 A CN 107213172A CN 201710440889 A CN201710440889 A CN 201710440889A CN 107213172 A CN107213172 A CN 107213172A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
The present invention relates to a kind of Asclerol oral liquid and preparation method thereof, the method for the invention comprises the following steps：Step 1, step 5 halimasch one grade fermemtation, step 2, halimasch second order fermentation, step 3, halimasch three grade fermemtation, step 4, the processing of Armillaria mellea fermented solution, prepare Asclerol oral liquid, method is：Honey 450g heating refinings (90 100 DEG C) are taken, filtration lets cool, mixed with ground royal jelly, the ethanol of obtained halimasch concentrate, sodium benzoate 3g and the essence of above-mentioned steps 4 is added, is mixed, adjustment total amount to 1000ml, stir evenly, filter, produce.
Description
Technical field：
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, in more particularly to a kind of strengthening by means of tonics, tranquilizing and allaying excitement
Medicine preparation Asclerol oral liquid and preparation method thereof.
Background technology：
Asclerol oral liquid is a kind of strengthening by means of tonics listed, the Chinese patent medicine preparation of tranquilizing and allaying excitement.It is empty for body
Weak, confused and worried, insomnia and dreamful sleep, neurasthenia, dizziness of having a headache belongs to above-mentioned patient, and its formula is as follows：
(1000ml recipe quantities)
Its preparation method is as follows：
Halimasch concentrate technique：
The culture medium of 60% volume is put in fermentation tank, water proof heat sterilization 30 minutes, connect with pressure differential method three-level seed in
In seeding tank, 26-28 DEG C is cultivated 4-6 days, is transferred in fermentation tank, and 26-28 DEG C is continued to cultivate 6-7 days, treats that zymotic fluid is changed into purple brown
Color, by thick thinning, part mycelia starts self-dissolving, and mycelia particle becomes broken, and pH value is down to brightness in 5.20-5.60, tank and starts decrease,
Tank can be gone out.Halimasch fermentation culture by fermentation is continued to be concentrated into relative density 1.030-1.035 (20 DEG C), produced
Halimasch concentrate.
60L seed tank culture bases：Edible wheat bran 200g, human consumption soybean dregs of rice 200g, starch 100g, sucrose 100g, peptone
100g, fructose syrup 100g, soybean oil 100ml, magnesium sulfate 20g, potassium dihydrogen phosphate 20g.Take food with wheat bran and the human consumption soybean dregs of rice
Plus 5 times of amount water soak 30-60 minutes, heating is boiled 1 hour, is filtered, and is cooled down standby.Extracted in edible wheat bran and the human consumption soybean dregs of rice
Add other raw materials in liquid.Other are scaling up.
Fermentation culture conditions are controlled：Compressed air is passed through, throughput is 1:0.3-1:0.5v/v.min, cultivation temperature is
26-28 DEG C, cultivation cycle is 4-6 days.Pressure inside the tank (0.4-0.5 × 10 are checked at any time5Pa), temperature (26-28 DEG C), acid-base value
(60L pH values are that 6.20-6.60,200LPH value are that 5.80-6.20,2000L pH value are 5.20-5.60)
Patent medicine technique：
Honey 450g heating refinings (90-100 DEG C) are taken, filtration lets cool, mixed with ground royal jelly, add honey
The ethanol of ring bacterium concentrate, sodium benzoate 3g and essence, is mixed, and adjustment total amount is stirred evenly to 1000ml, is filtered, is produced.
Halimasch concentrate prepared by prior art, fermentation yield is low, is difficult to remove containing multiple polypeptides class impurity component,
If removed, ample resources can be lost, causes cost to raise, the wasting of resources.Preparation method of the present invention to halimasch concentrate
Studied, obtain a kind of new preparation method, by detection, wherein polypeptide impurities composition declines, active ingredient N6- (5-
Hydroxyl -2- pyridylmethylaminojphenyls) content of -9- β-purine nucleosides greatly improves.
The content of the invention
We provide a kind of halimasch new fermentation extraction method, and methods described comprises the following steps：
Step 1, one grade fermemtation
Culture medium prescription：Edible wheat bran 200g, human consumption soybean dregs of rice 200g, starch 100g, sucrose 100g, peptone 100g,
Fructose syrup 100g, soybean oil 100ml, potassium dihydrogen phosphate 40g, magnesium sulfate 20g, sodium alginate 5g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 37L-39L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in by pressure differential method
In 60L seeding tanks；Air is passed through, throughput is 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105pa、
26-28 DEG C of temperature, pH value are 6.20-6.60；Obtain halimasch one grade fermemtation nutrient solution；
Step 2, second order fermentation
Culture medium prescription：Edible wheat bran 600g, human consumption soybean dregs of rice 600g, starch 300g, sucrose 300g, peptone 300g,
Fructose syrup 300g, soybean oil 300ml, potassium dihydrogen phosphate 120g, magnesium sulfate 60g, sodium alginate 15g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 70L-80L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in by pressure differential method
In 200L fermentation tanks；It is passed through air, throughput 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105pa、
26-28 DEG C of temperature, pH value are 5.80-6.20；Obtain halimasch second order fermentation nutrient solution；
Step 3, three grade fermemtation
Culture medium prescription：Edible wheat bran 7.50kg, human consumption soybean dregs of rice 7.50kg, starch 3.75kg, sucrose 3.75kg, albumen
Peptone 3.75kg, fructose syrup 3.75kg, soybean oil 3750ml, potassium dihydrogen phosphate 1500g, magnesium sulfate 750g, sodium alginate 200g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 1000L-1100L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and pressure differential method obtains step 2
To halimasch second order fermentation nutrient solution be inoculated in 2000L fermentation tanks, throughput 1:0.3-1:0.5v/v.min, temperature is 26-
28 DEG C, continue 6-8 days, pressure 0.4-0.5 × 105Pa, pH value are 5.20-5.60, treat that zymotic fluid is changed into puce, are become by thick
Dilute, part mycelia starts self-dissolving, and mycelia particle becomes broken, and pH value is down to brightness in 5.20 or so, tank and starts decrease, you can under progress
One step；
Step 4, the processing of zymotic fluid
Inactivation：121 DEG C of 0.10-0.12mpa are inactivated 40 minutes；
Thickening filtration：Zymotic fluid is concentrated into relative density for 1.030-1.035 ﹙, 20 DEG C of Jian Ce ﹚, and concentration time is that 1-2 is small
When, filtering produces halimasch three grade fermemtation concentrate；
Step 5, honey 450g heating refinings are taken, filtration lets cool, mixed with ground royal jelly, adds step 4 and obtains
Halimasch the concentrate 600g, sodium benzoate 3g and the ethanol of essence arrived, is mixed, and adjustment total amount is stirred evenly to 1000ml, is filtered
Cross, produce.
Beneficial effects of the present invention are further illustrated below by way of test data：
1st, analgesic activity
It is to show as licking sufficient number of times to investigate the rat influence pain caused to hot plate.The identical week old, body weight is taken to be about respectively
300g rats 40, are randomly divided into 4 groups, respectively blank group (drinking water), positive controls (oral aspirin) and this hair
Bright 1 group of embodiment, prior art group.Successive administration five days, twice daily.60 DEG C of difference of hot plate pain threshold detector are utilized after last dose
The number of times of metapedes is licked after measurement mouse administration, it is as a result as follows：
The rat influence pain caused to hot plate
Of the present invention group can obviously reduce the number of times that rat licks metapedes as can be known from the above table, with significant analgesic activity, and
It, which is acted on, is better than prior art group.
2nd, Cerebral Ischemia is prevented and treated：
Influence of the mouse to cerebral ischemia is investigated, it is about 50g mouse 40 that identical week old, body weight are taken respectively, is randomly divided into 4
1 group of group, respectively blank group (drinking water), positive controls (oral " Xuesaitong Injection ") and the embodiment of the present invention, prior art group.Even
Continuous administration ten days, once a day.Last dose breaked end mouse after 2 hours, recorded mouse broken end posttension mouth number of times certainly, as a result such as
Under：
Opened one's mouth number of times after mouse broken end
Present invention group substantially increases number of times of panting of being opened one's mouth after mouse broken end as can be known from the above table, extends its time-to-live, and
It, which is acted on, is better than prior art group.
3rd, halimasch concentrate comparison of ingredients：
Advantages of the present invention is as follows：
1st, the present invention uses three grade fermemtation method, it is ensured that bacterial strain recovery obtains the vigorous bacterial strain of single purifying, stable vitality；
2nd, the present invention prepares high yield halimasch concentrate using three grade fermemtation method, specify that the composition and ratio of culture medium
Example.Three grade fermemtation method is per one-level fermentation medium amount and controlled pH value is different, and inoculation amount is 15%, generation bacterial strain hair
Culture base unit weight can be optimized while zymotic fluid cost-effective；
3rd, culture medium of the present invention is with peptone nitrogen source best for needed for strain growth, other compositions such as wheat bran, edible big
The wide material sources such as dregs of beans, starch, production cost is greatly reduced while cheap environmentally friendly, and it is higher to obtain content with this, many
Peptide impurity is few, the significantly more concentrate of drug action；
4th, liquid fermentation has the cycle short compared to solid fermentation liquid fermentation, and cost is low, yield is big, suitable for factory's metaplasia
The remarkable advantages such as production.
Embodiment：
The present invention is further illustrated by the following examples.
Embodiment 1,
A kind of new fermentation extraction method of halimasch, methods described comprises the following steps：
Step 1, one grade fermemtation
Culture medium prescription：Edible wheat bran 200g, human consumption soybean dregs of rice 200g, starch 100g, sucrose 100g, peptone 100g,
Fructose syrup 100g, soybean oil 100ml, potassium dihydrogen phosphate 40g, magnesium sulfate 20g, sodium alginate 5g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 37L-39L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in by pressure differential method
In 60L seeding tanks；It is passed through air, throughput 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105pa, temperature
26-28 DEG C of degree, pH value are 6.20-6.60；Obtain halimasch one grade fermemtation nutrient solution；
Step 2, second order fermentation
Culture medium prescription：Edible wheat bran 600g, human consumption soybean dregs of rice 600g, starch 300g, sucrose 300g, peptone 300g,
Fructose syrup 300g, soybean oil 300ml, potassium dihydrogen phosphate 120g, magnesium sulfate 60g, sodium alginate 15g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 70L-80L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in by pressure differential method
In 200L fermentation tanks；It is passed through air, throughput 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105pa,
26-28 DEG C of temperature, pH value are 5.80-6.20；Obtain halimasch second order fermentation nutrient solution；
Step 3, three grade fermemtation
Culture medium prescription：Edible wheat bran 7.50kg, human consumption soybean dregs of rice 7.50kg, starch 3.75kg, sucrose 3.75kg, albumen
Peptone 3.75kg, fructose syrup 3.75kg, soybean oil 3750ml, potassium dihydrogen phosphate 1500g, magnesium sulfate 750g, sodium alginate 200g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and it is small that heating boils 1
When, filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 1000L-1100L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and pressure differential method obtains step 2
To halimasch second order fermentation nutrient solution be inoculated in 2000L fermentation tanks, throughput 1:0.3-1:0.5v/v.min, temperature is 26-
28 DEG C, continue 6-8 days.Pressure 0.4-0.5 × 105Pa, pH value are 5.20-5.60, treat that zymotic fluid is changed into puce, are become by thick
Dilute, part mycelia starts self-dissolving, and mycelia particle becomes broken, pH value drop 5.20 or so, and brightness starts to weaken in tank, you can carry out next
Step；
Step 4, the processing of zymotic fluid
Inactivation：121 DEG C of 0.10-0.12mpa are inactivated 40 minutes；
Thickening filtration：Zymotic fluid is concentrated into relative density for 20 DEG C of Jian Ce ﹚ of 1.030-1.035 ﹙, and concentration time is that 1-2 is small
When, filtering produces halimasch three grade fermemtation concentrate.
Embodiment 2
The preparation of Asclerol oral liquid：
Honey 450g heating refinings (90-100 DEG C) are taken, filtration lets cool, mixed with ground royal jelly, add honey
The ethanol of ring bacterium concentrate, sodium benzoate 3g and essence, is mixed, and adjustment total amount is stirred evenly to 1000ml, is filtered, is produced.
Claims (1)
1. a kind of preparation method of Asclerol oral liquid, methods described comprises the following steps：
Step 1, one grade fermemtation
Culture medium prescription：Edible wheat bran 200g, human consumption soybean dregs of rice 200g, starch 100g, sucrose 100g, peptone 100g, fruit Portugal
Syrup 100g, soybean oil 100ml, potassium dihydrogen phosphate 40g, magnesium sulfate 20g, sodium alginate 5g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and 1 hour, mistake are boiled in heating
Filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 37L-39L that adds water is sterilized 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in 60L by pressure differential method
In seeding tank；Air is passed through, throughput is 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105Pa, temperature
26-28 DEG C of degree, pH value are 6.20-6.60；Obtain halimasch one grade fermemtation nutrient solution；
Step 2, second order fermentation
Culture medium prescription：Edible wheat bran 600g, human consumption soybean dregs of rice 600g, starch 300g, sucrose 300g, peptone 300g, fruit Portugal
Syrup 300g, soybean oil 300ml, potassium dihydrogen phosphate 120g, magnesium sulfate 60g, sodium alginate 15g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and 1 hour, mistake are boiled in heating
Filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 70L-80L that adds water is sterilized 40 minutes in 0.1-0.2mpa, 121 DEG C, and halimasch is inoculated in 200L by pressure differential method
In fermentation tank；It is passed through air, throughput 1:0.3-1:0.5v/v.min, continues 4-6 days, pressure 0.4-0.5 × 105Pa, temperature
26-28 DEG C, pH value be 5.80-6.20；Obtain halimasch second order fermentation nutrient solution；
Step 3, three grade fermemtation
Culture medium prescription：Edible wheat bran 7.50kg, human consumption soybean dregs of rice 7.50kg, starch 3.75kg, sucrose 3.75kg, peptone
3.75kg, fructose syrup 3.75kg, soybean oil 3750ml, potassium dihydrogen phosphate 1500g, magnesium sulfate 750g, sodium alginate 200g；
The preparation of culture medium：Edible wheat bran and the human consumption soybean dregs of rice add 5 times of amount water to soak 30-60 minutes, and 1 hour, mistake are boiled in heating
Filter, cooling adds other above-mentioned raw materials, stirred；
Cultural method：The 1000L-1100L that adds water sterilizes 40 minutes in 0.1-0.2mpa, 121 DEG C, and pressure differential method obtains step 2
Halimasch second order fermentation nutrient solution is inoculated in 2000L fermentation tanks, throughput 1:0.3-1:0.5v/v.min, temperature is 26-28 DEG C,
Continue 6-8 days, pressure 0.4-0.5 × 105Pa, pH value are 5.20-5.60, treat that zymotic fluid is changed into puce, by thick thinning, part
Mycelia starts self-dissolving, and mycelia particle becomes broken, and pH value is down to brightness in 5.20 or so, tank and starts decrease, you can carry out next step；
Step 4, the processing of zymotic fluid
Inactivation：121 DEG C of 0.10-0.12mpa are inactivated 40 minutes；
Thickening filtration：Zymotic fluid is concentrated into relative density for 1.030-1.035 ﹙, 20 DEG C of Jian Ce ﹚, and concentration time is 1-2 hours,
Filtering, produces halimasch three grade fermemtation concentrate；
Step 5, honey 450g heating refinings are taken, filtration lets cool, mixed with ground royal jelly, add what step 4 was obtained
Halimasch concentrate 600g, sodium benzoate 3g and essence ethanol, are mixed, and adjustment total amount is stirred evenly to 1000ml, is filtered, i.e.,
.
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| CN201710440889.9A CN107213172A (en) | 2017-06-13 | 2017-06-13 | Asclerol oral liquid and preparation method thereof |
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| CN201710440889.9A CN107213172A (en) | 2017-06-13 | 2017-06-13 | Asclerol oral liquid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374991A (en) * | 2020-04-21 | 2020-07-07 | 广东一力罗定制药有限公司 | Oral liquid for treating brain and heart diseases and its preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1002539A1 (en) * | 1998-11-20 | 2000-05-24 | Asama Chemical Co., Ltd. | Immunomodulator comprising bacterial cells or cell wall decomposition products thereof |
| CN1310953A (en) * | 2000-12-21 | 2001-09-05 | 安徽林苑虫草研究所 | Honey mushroom noodles and industrialized liquid fermentation producing technology for honey mushroom bacterial strain |
| CN101143002A (en) * | 2007-09-03 | 2008-03-19 | 江苏省江大绿康生物工程技术研究有限公司 | Deep liquid fermentation method for preparing selenium-rich gold needle mushroom crude polysaccharide powder |
-
2017
- 2017-06-13 CN CN201710440889.9A patent/CN107213172A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1002539A1 (en) * | 1998-11-20 | 2000-05-24 | Asama Chemical Co., Ltd. | Immunomodulator comprising bacterial cells or cell wall decomposition products thereof |
| CN1310953A (en) * | 2000-12-21 | 2001-09-05 | 安徽林苑虫草研究所 | Honey mushroom noodles and industrialized liquid fermentation producing technology for honey mushroom bacterial strain |
| CN101143002A (en) * | 2007-09-03 | 2008-03-19 | 江苏省江大绿康生物工程技术研究有限公司 | Deep liquid fermentation method for preparing selenium-rich gold needle mushroom crude polysaccharide powder |
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部 药品标准 中药成方制剂 第二十册》", 31 December 1998 * |
| 刘亚明: "《发酵技术在中医药中的应用》", 31 March 2010, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111374991A (en) * | 2020-04-21 | 2020-07-07 | 广东一力罗定制药有限公司 | Oral liquid for treating brain and heart diseases and its preparation method |
| CN111374991B (en) * | 2020-04-21 | 2021-10-22 | 一力制药(罗定)有限公司 | Oral liquid for treating brain and heart diseases and its preparation method |
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Application publication date: 20170929 |