CN107198682A - A kind of refrigerant anesthetic and its application - Google Patents
A kind of refrigerant anesthetic and its application Download PDFInfo
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- CN107198682A CN107198682A CN201610154061.2A CN201610154061A CN107198682A CN 107198682 A CN107198682 A CN 107198682A CN 201610154061 A CN201610154061 A CN 201610154061A CN 107198682 A CN107198682 A CN 107198682A
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- anesthetic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/035—Halogenated hydrocarbons having aliphatic unsaturation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
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Abstract
The invention discloses a kind of refrigerant anesthetic and its application, the refrigerant anesthetic is by 1,1,13, and 3 pentafluoropropanes and the trans propylene of 1,3,3,3 tetrafluoro 1 are constituted.Present invention can apply to the crymoanesthesia medically to tissues such as skin, mucous membranes.Mist type or jet flow type spray can be made in the present invention, be locally applied to skin, complete mucous membrane and open small wound, injection, pain caused by minor operation can effectively be controlled, also can the effectively small injury gained in sports of temporary relief, such as sprain, dampen, hurting, abrading the pain of situation.Wherein, jet flow type spray can also be used for the auxiliary treatment of myofacial pain, limitation of movement and muscular tone.
Description
Technical field
The present invention relates to a kind of refrigerant anesthetic, and the refrigerant anesthetic is in skin, mucous membrane and open small wound
Application in terms of the refrigeration anesthesia of surface.
Background technology
In clinical medicine, local anesthetic can occur with passing in the blocking sensory nerve impulsion of medication local reversible
Pass, general, the effect of local anesthetic is confined to medicine-feeding part and spreads and rapidly disappear from medicine-feeding part with medicine.It is conventional
Local anesthetic have procaine, lidocaine etc. can be widely used for infiltration anesthesia and inducing neural retardance, its deficiency
Place is must to give high concentration when using, and thus can increase the risk of tissue stimulation and tissue damage, and side effect is larger.For certain
A little situations, external application local anesthetic is more conducive to improve safety in utilization and convenience relative to injecting narcotic.At present, outside skin
It is the emulsion containing ethanol solution, cream agent or gel, the local anaesthesia of such as current more prevalence mostly with the matrix of anesthetic
5% grace receives (EMLA) frost, lidocaine ointment, dyclonine emulsifiable paste, fat-soluble dicaine etc..In order to further reduce risk,
People have invented liquid nitrogen frozen anesthesia procedures, and a kind of include the refrigerant anesthetic of HFC-134a, lotus oil and ethanol.Based on cold
Freeze the good characteristic of anesthetic clinically, more new formula new products are also constantly emerging in large numbers.
Anti-form-1,3,3,3- tetrafluoro-1-propenes, molecular formula C3H2F4, referred to as trans HFO-1234ze is under normal temperature and pressure
Gas, usually gases at high pressure, liquefied gas.In the industry, the compound has very many purposes, such as refrigerant, hair
Infusion, cleaning agent, insecticides adjuvant etc., are also used as medical disinfectant component and use.For the further application of the compound,
Particularly in terms of medical field, still few achievements in research, especially potential clinical practice.The present inventor exists always
In constantly exploring and study, it would be highly desirable to be applied to refrigerant anesthetic using its frozen characters.
The content of the invention
The present invention is intended to provide a kind of refrigerant anesthetic, and by refrigerant anesthetic application in the medical field, to obtain
The freezing partly of skin, mucous membrane and open small wound must be anaesthetized.
The solution that the present invention is provided is as follows：
A kind of refrigerant anesthetic, by weight percentage, is made up of following composition：
85-97% 1,1,1-3,3- pentafluoropropane,
3-15% anti-form-1s, 3,3,3- tetrafluoro-1-propenes.
Wherein, formula preferably is：
90-95% 1,1,1-3,3- pentafluoropropane,
5-10% anti-form-1s, 3,3,3- tetrafluoro-1-propenes.
In the refrigerant anesthetic provided according to the demand of form of medication and product, the present invention, this area skill can be added
The suitable appropriate medical accessory that art personnel commonly use, such as the auxiliary material such as ethanol, the present invention is not added with any restriction to this.With weight hundred
Divide than meter, refrigerant anesthetic preferably is made up of following component：
85-97% 1,1,1-3,3- pentafluoropropane,
3-15% anti-form-1s, 3,3,3- tetrafluoro-1-propenes, and
Appropriate amount of auxiliary materials.
Further, above-mentioned refrigerant anesthetic is medically applied by the spray form of spray delivery, wherein, the spraying
Agent can be mist type or jet flow type.
Above-mentioned 1,1,1-3,3- pentafluoropropanes, molecular formula：CF3CH2CHF2, chemical abstracts numbering (CAS No.)：460-
73-1, abbreviation HFC-245fa.It is colourless liquid, saturated vapor pressure (20 °C) 122.7KPa, fluid density under normal pressure, at 15 DEG C
(20 DEG C) 1.32g/ml, is solubility (PH 8.11-8.62 room temperatures) 7180mg/L in colourless gas, water at 20 DEG C.At present,
HFC-245fa is mainly used in foaming agent, such as hard polyaminoester and polyisocyanurate foam, ambroin foaming, thermal insulating material
Material foaming etc..
In industrial circle, HFC-245fa can also be used alone as refrigerant, can also be matched somebody with somebody with other components and be used as refrigeration
Agent.In the present invention, HFC-245fa is under condensing temperature, mainly as the injection power resources of spray.
Above-mentioned anti-form-1,3,3,3- tetrafluoro-1-propenes are nontoxic, nonflammable, do not damage the ozone layer, when stopping in an atmosphere
Between short, the influence very little to environment, stable chemical performance, compared with other refrigerants have obvious advantage.The present invention breaks through
Property by anti-form-1,3,3,3- tetrafluoro-1-propenes are applied to the crymoanesthesia in medical field.Anesthetic can be played by cooling
Effect, i.e. anti-form-1,3,3,3- tetrafluoro-1-propenes can reduce the temperature of the tissue regions in tissue surface rapid evaporation
Degree, this effect sustainable certain time, produces anaesthetic effect immediately.Shown by substantial amounts of experiment and clinical data, it is above-mentioned
Refrigerant anesthetic can be applied as medically being anaesthetized to the surface freezing of skin, mucous membrane and open small wound, have
Good anaesthetic effect, and with splendid security.
1,1,1-3, the 3- pentafluoropropanes included in product of the present invention can as spray injection power resources, simultaneously
With anti-form-1,3,3,3- tetrafluoro-1-propenes produce synergy, and its mixture forms relatively low evaporation rate, by special
Release system, is distributed to skin surface and evaporates immediately, forms the cooling effect of moment, makes the C of composition peripheral nervous system fine
The MNCV of peacekeeping A- δ fibers slows down, so as to block the myelopetal input of pain.
The cryospray agent (skin refrigerant) that the present invention is provided, can be locally applied to skin, complete mucous membrane (such as mouth
Chamber, nasal passage and lip etc.) and open small wound.Mist type and jet flow type be used to control injection (such as venipuncture,
Intravenous injection, cosmetic surgery etc.), pain caused by minor operation (such as excision furuncle, apocenosis, suture needle etc.), and can temporary relief it is small
Injury gained in sports, such as sprain, dampen, hurting, abrading the pain of situation.It is preferred that, the present invention freezes spray using jet flow type
During mist agent, also available for counterirritation, such as auxiliary treatment of myofascial pain, limitation of movement and muscular tone.
Embodiment
The present invention is described in detail by the following examples.
1,1,1-3,3- pentafluoropropanes and anti-form-1 used in the embodiment of the present invention, 3,3,3- tetrafluoro-1-propenes reach
Medically acceptable standard, can be commercially available in the market.During production, after two kinds of raw materials are mixed in proportion, by two kinds of originals
Material enters container through valve, carries out pressure filling, then covers, stop leakage in the roof.As medically workable spray, no matter
It is jet flow type or mist type, those skilled in the art can produce according to well-known method, the present invention does not appoint to this
What is limited.
Specific formula is constituted, and see the table below：
| 1,1,1-3,3- pentafluoropropanes | Anti-form-1,3,3,3- tetrafluoro-1-propenes | |
| Embodiment 1 | 850g | 150g |
| Embodiment 2 | 900g | 100g |
| Embodiment 3 | 930g | 70g |
| Embodiment 4 | 950g | 50g |
Application method：
Using the mist type crymoanesthesia spray of above-mentioned acquisition, tank body can be grasped, apart from treatment position 5-
20 centimetres of distant places, firmly press actuator button, allow product to be sprayed out of tank.According to following different clinical setting, its is specific
Application method is：
1st, anaesthetized before injecting
Area for treatment is wiped with disinfectant, from apart from the 5-20 centimetres remote injection of area for treatment about 4-10 seconds.When skin is taut
Tightly enter pin rapidly.It can repeat again as needed.Other kinds of injection can also be noted by this program, such as vein
Penetrate, venipuncture etc..
2nd, minor operation local anaesthesia：Area for treatment is wiped with disinfectant, adjacent domain is protected with vaseline, from distance treatment
The 5-20 centimetres remote injection in region about 4-10 seconds.Rapid otch, the anesthetic effect of pain relief continues several seconds to 1 minute, according to
Need to repeat.
3rd, as pain of alleviation is mitigated in use, grasp the tank body of spray, tank body is upright, from 30 to 46cm distances
Spraying, so that fluid can meet the demand of skin to mitigate the influence of fluid impact.Swept so that about 10cm per second speed is parallel
Retouch 1.5 and arrive 2cm Direct sprayings, until whole muscle is capped, the numerical value of scanning is determined by the area of muscle, makes flesh by spraying
Meat is stretched, and gradually increases the intensity continuously scanned.Due to loosening all muscles, by being formed, new tensile elongation smoothly reaches
Muscular flaccidity, muscle reaches that completely normal length contacts can be completely ineffective, could mitigate pain, make it recover to live
Power.If it is necessary, repeating this process.Kept after treatment damp and hot 10 to 15 minutes, exclude any factor for producing trigger mechanism.
First, the evaluation of performance is anaesthetized
A. animal
Using the male and female rats for meeting pharmacy clinical trial standard, body weight is between 200g to 300g.
B. freezing partly is anaesthetized
Experiment is divided into experimental group and control group below.The product that above-described embodiment is obtained is corresponding in turn to one group of experiment, its
In, the site of anesthesia that experiment is implemented is the belly of rat, and spray is mist type.Each animal carries out 3 administrations, each test
Using 2 animals, listed numerical value is average value in following table.To assess anaesthetic effect, clicked through with tip tweezers in each application
Row mechanical stimulus (in table be " acupuncture "), when observing the local contraction of skin after mechanical stimulus, it is believed that the position not by
Anesthesia, that is, keenly feel obvious.The time of assessment is 60 seconds (min).
Above-mentioned experiment shows that the present invention has the effect of local anesthesia to animal skin surfaces, under effective dose, fiber crops
The liquor-saturated time is not less than 30 seconds.
2nd, the evaluation of myalgia performance is alleviated
A. clinical case
In order to evaluate the present invention for the treatment of myofascial pain, limitation of movement and muscular tone for the illness of cardinal symptom,
The present invention has carried out substantial amounts of clinical observation before applying for a patent.
Patient of the selection age between 25-55 Sui, male or female, totally 30 cases, by clinical observation, draw following comment
Valency result, including 5 clinics have pain in the back (due to muscular tone) illness, 5 clinics have ankle from sprains illness, 5
Clinic have the acute illness that has a stiff neck, 5 clinics have torticollis illness, 5 tight masseter antalgesics as caused by trigger point,
5 clinics have acute shoulder bursal synovitis illness.
B. treatment method
Using the jet flow type crymoanesthesia spray of above-mentioned acquisition, tank body can be grasped, apart from treatment position 5-
20 centimetres of distant places, firmly press actuator button, allow product to be sprayed out of tank, remote injection about 4-10 seconds, and avoid being ejected into
Outside area for treatment, until skin starts to bleach.Use on demand, be careful not to freezing skin/region.
C. efficacy assessment standard
Cure：Symptom and sign is wholly absent.
Effectively：Symptom and sign mitigates earlier above.
It is invalid：Symptom and sign with it is preceding without improvement.
D. treatment results
Clinical cure 0, accounts for 0%；Effective 30, invalid 0, total effective rate is 100%.All patients it is ache related
Symptom has a certain degree of alleviation.
By clinical observation, jet flow type spray products of the invention can be controlled as counter-stimulus myofacial pain,
Limitation of movement and muscle tonue pain.Jet flow type anodyne can be used for clinical manifestation to be pain in the back (due to muscular tone), acute neck
Stiff, torticollis, acute shoulder bursal synovitis, tight hamstring, ankle from sprains, the tight masseter as caused by trigger point are ache related.It is slow
Solve mobilization and recovery that pain promotes early stage muscle function.
Clinical observation shows that either the cryospray agent of mist type or jet flow type of the invention, can be used as one
Auxiliary treatment means are planted, the pain damaged for temporary relief light exercise, including by wounding, dampen, swelling, small sprains,
Pain caused by incised wound and scratch.Cooling degree depends on dosage, and dosage is relevant with injection duration, and the action time is sufficiently used for
Slow down general pain.The method used is that, from apart from 5-20 centimetres of injection of area for treatment, the anesthetic effect of pain relief can be held
It is continuous several seconds to 1 minute, it can repeat as needed.
The present invention is not limited to embodiment discussed above.The description to embodiment is intended to explain and said above
Bright technical scheme of the present invention.Above-described embodiment is used for disclosing the optimal implementation of the present invention, with
One of ordinary skill in the art is enabled to reach this using the numerous embodiments and a variety of alternatives of the present invention
The purpose of invention.The obvious conversion or replacement that are enlightened based on the present invention should also be as being considered within the protection model of the present invention
Enclose.
Claims (6)
1. a kind of refrigerant anesthetic, it is characterised in that by weight percentage, is made up of following composition：
85-97% 1,1,1-3,3- pentafluoropropane,
3-15% anti-form-1s, 3,3,3- tetrafluoro-1-propenes；
Or,
85-97% 1,1,1-3,3- pentafluoropropane,
3-15% anti-form-1s, 3,3,3- tetrafluoro-1-propenes, and
Appropriate amount of auxiliary materials.
2. refrigerant anesthetic as claimed in claim 1, it is characterised in that the composition is：
90-95% 1,1,1-3,3- pentafluoropropane,
5-10% anti-form-1s, 3,3,3- tetrafluoro-1-propenes.
3. refrigerant anesthetic as claimed in claim 1 or 2, it is characterised in that the refrigerant anesthetic passes through spray delivery
Spray form is medically applied.
4. refrigerant anesthetic as claimed in claim 3, it is characterised in that the spray of the refrigerant anesthetic can be mist
Type or jet flow type.
5. refrigerant anesthetic as claimed in claim 1, it is characterised in that the Main Ingredients and Appearance of the auxiliary material is ethanol.
6. the refrigerant anesthetic as described in any in a kind of 1-5 such as claim, can be applied to medically to skin, mucous membrane and opens
The surface freezing anesthesia of putting property minor cut or wound, and for auxiliary treatment myofacial pain, limitation of movement and muscular tone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610154061.2A CN107198682A (en) | 2016-03-17 | 2016-03-17 | A kind of refrigerant anesthetic and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610154061.2A CN107198682A (en) | 2016-03-17 | 2016-03-17 | A kind of refrigerant anesthetic and its application |
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| Publication Number | Publication Date |
|---|---|
| CN107198682A true CN107198682A (en) | 2017-09-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610154061.2A Pending CN107198682A (en) | 2016-03-17 | 2016-03-17 | A kind of refrigerant anesthetic and its application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113712921A (en) * | 2021-09-02 | 2021-11-30 | 沈阳德隆医疗器械有限公司 | Novel rapid local pain-relieving hemostatic and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
-
2016
- 2016-03-17 CN CN201610154061.2A patent/CN107198682A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
Non-Patent Citations (1)
| Title |
|---|
| 吴四清: "第4代含氟制冷剂的发展（续完）", 《化工生产与技术》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113712921A (en) * | 2021-09-02 | 2021-11-30 | 沈阳德隆医疗器械有限公司 | Novel rapid local pain-relieving hemostatic and application thereof |
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Application publication date: 20170926 |
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