CN107184940A - Medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated and preparation method thereof - Google Patents

Medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated and preparation method thereof Download PDF

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Publication number
CN107184940A
CN107184940A CN201710467940.5A CN201710467940A CN107184940A CN 107184940 A CN107184940 A CN 107184940A CN 201710467940 A CN201710467940 A CN 201710467940A CN 107184940 A CN107184940 A CN 107184940A
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Prior art keywords
parts
medicine
function
spleen
assimilated
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CN201710467940.5A
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Inventor
周奇
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Hangzhou Bi Hua Biological Technology Co Ltd
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Hangzhou Bi Hua Biological Technology Co Ltd
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Priority to CN201710467940.5A priority Critical patent/CN107184940A/en
Publication of CN107184940A publication Critical patent/CN107184940A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated, it is characterised in that：The medicine is prepared from by the component of following quality point：100~135 parts of cardamom, 100~135 parts of fructus amomi, 100~135 parts of orange peel, 100~135 parts of pawpaw, 130~165 parts of hawthorn, 100~135 parts of malt, interior golden 100~135 parts, 100~135 parts of ginger, 100~135 parts of Buddha's hand, 100~135 parts of Poria cocos.It has the effect that function of spleen and stomach regulating function, promotion are digested and assimilated, and it is used for functional dyspepsia FD and gastroenteritic power is not enough.The medicine is Chinese medicine preparation, and its Small side effects is determined after clinical testing data is analyzed, obvious adverse reaction is had no.

Description

Medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated and preparation method thereof
Technical field
Medicine digested and assimilated the present invention relates to a kind of function of spleen and stomach regulating function, promotion and preparation method thereof, belongs to medicine Preparation field.
Background technology
With the continuous quickening of people's live and work paced environment, and diet is irregular, and increasing people goes out Showed gastrointestinal dysfunction, stomach and intestine evacuating pipeline abdomen delay, stomach and situations such as esophageal regurgitation, there is the swollen vexed, belch of upper abdomen, upper abdomen The symptoms such as portion's pain, Nausea and vomiting, clinically give promotes the Western medicine of gastroenteritic power to be treated more, and clinical and city at present The medicine effect of field sale is not ideal, and toxic side effect is big, can bring many adverse reactions, and clinical and in the market is badly in need of curative effect More preferably, and the natural drug that has no toxic side effect.
The content of the invention
Goal of the invention：
The present invention provides a kind of function of spleen and stomach regulating function, promotes medicine for digesting and assimilating and preparation method thereof, the purpose is to solve with The problems of toward.
Technical scheme：
The medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated, it is characterised in that：The component system that the medicine is divided by following quality It is standby to form：
100~135 parts of cardamom, 100~135 parts of fructus amomi, 100~135 parts of orange peel, 100~135 parts of pawpaw, hawthorn 130~165 Part, 100~135 parts of malt, interior golden 100~135 parts, 100~135 parts of ginger, 100~135 parts of Buddha's hand, Poria cocos 100~135 Part.
120 parts of cardamom, 120 parts of fructus amomi, 120 parts of orange peel, 120 parts of pawpaw, 150 parts of hawthorn, 120 parts of malt, interior golden 120 Part, 120 parts of ginger, 120 parts of Buddha's hand, 120 parts of Poria cocos.
Prepare a kind of above-mentioned function of spleen and stomach regulating function, the method for the medicine that promotion is digested and assimilated, it is characterised in that：This method Step is as follows：Above-mentioned 10 taste medicinal material is taken to be extracted 1~3 hour with 4~8 times of amount water, filtering is concentrated into relative density for 1.2-1.35 Clear cream；Qinghuo reagent powder, plus 2~3.5 parts of sodium carboxymethyl starch, 0.3~0.55 part of magnesium stearate always mix, tabletting, i.e., .
（1）, by cardamom, fructus amomi, orange peel and Nei Jin, it is standby to grind to form 80 mesh powder, and pawpaw, ginger and Poria cocos are cut into the length of side It is standby for 0.5cm block, hawthorn is standby from axially breaking, Buddha's hand is cut into every section of 0.5cm standby；
（2）, will（1）The medicine of step is placed in container together with malt, is soaked 20~40 minutes, is then heated to and boils Boiling, is kept for 10~20 minutes, then separates fried liquid, and the dregs of a decoction are in accordance with the law repeatedly fried to amount to 1~3 hour used time, and decocting liquid is lightly seasoned to be Only, each fried liquid is merged, the consumption of water is the water of all 4~8 times of amounts of medicinal materials；
（3）, be concentrated into relative density for 1.2-1.35g/cm3Clear cream；Qinghuo reagent powder, plus 2~3.5 parts of CMS Sodium and 0.3~0.55 part of magnesium stearate are always mixed, and tabletting is produced.
Film coating after tabletting, film clothing uses the premix coating agent of all materials total amount quality 3~5%.
The specification of tabletting is 0.6g/ pieces.
The consumption of the medicine is three every time, three times a day.
Advantageous effect：
The present invention provides a kind of function of spleen and stomach regulating function, medicine that promotion is digested and assimilated and preparation method thereof, with function of spleen and stomach regulating work( The effect digested and assimilated, can be promoted, it is used for functional dyspepsia FD and gastroenteritic power is not enough.The medicine is Chinese medicine preparation, warp Its Small side effects is determined after crossing clinical testing data analysis, obvious adverse reaction is had no.
Embodiment：
With reference to embodiment, the present invention is described in further detail：
Embodiment 1：
（1）, by 120 parts of cardamom, 120 parts of fructus amomi, 120 parts of orange peel and interior golden 120 parts, it is standby to grind to form 80 mesh powder, by pawpaw 120 Part, that 120 parts of 120 parts of ginger and Poria cocos are cut into the block that the length of side is 0.5cm is standby, and 150 parts of hawthorn is standby from axially breaking, by Buddhist It is standby that 120 parts of hand is cut into every section of 0.5cm；
（2）, will（1）The medicine of step is placed in container for 120 parts together with malt, is soaked 20 minutes, is then heated to Boil, kept for 20 minutes, then separate fried liquid, the dregs of a decoction repeatedly fried 1.5 hours in accordance with the law untill decocting liquid is lightly seasoned, merge each time Fried liquid, the consumption of water is the water of all 6 times of amounts of medicinal materials；
（3）, be concentrated into relative density be 1.27 clear cream；Qinghuo reagent powder, plus 2.7 parts of sodium carboxymethyl starch and 0.45 part Magnesium stearate is always mixed, tabletting, is produced.
Embodiment 2：
（1）, by 100 parts of cardamom, 135 parts of fructus amomi, 100 parts of orange peel and interior golden 100 parts, it is standby to grind to form 80 mesh powder, by pawpaw 100 Part, that 135 parts of 100 parts of ginger and Poria cocos are cut into the block that the length of side is 0.5cm is standby, and 130 parts of hawthorn is standby from axially breaking, by Buddhist It is standby that 100 parts of hand is cut into every section of 0.5cm；
（2）, will（1）The medicine of step is placed in container for 100 parts together with malt, is soaked 40 minutes, is then heated to Boil, kept for 10 minutes, then separate fried liquid, the dregs of a decoction repeatedly fried 1 hour in accordance with the law, untill decocting liquid is lightly seasoned, merge each time it is pan-fried Go out liquid, the consumption of water is the water of all 4 times of amounts of medicinal materials；
（3）, be concentrated into relative density be 1.20 clear cream；Qinghuo reagent powder, plus 2 parts of sodium carboxymethyl starch and 0.55 part are hard Fatty acid magnesium is always mixed, tabletting, is produced.
Embodiment 3：
（1）, by 135 parts of cardamom, 100 parts of fructus amomi, 135 parts of orange peel and interior golden 135 parts, it is standby to grind to form 80 mesh powder, by pawpaw 135 Part, that 100 parts of 135 parts of ginger and Poria cocos are cut into the block that the length of side is 0.5cm is standby, and 165 parts of hawthorn is standby from axially breaking, by Buddhist It is standby that 135 parts of hand is cut into every section of 0.5cm；
（2）, will（1）The medicine of step is placed in container for 135 parts together with malt, is soaked 30 minutes, is then heated to Boil, kept for 15 minutes, then separate fried liquid, the dregs of a decoction repeatedly fried 3 hours in accordance with the law, untill decocting liquid is lightly seasoned, merge each time it is pan-fried Go out liquid, the consumption of water is the water of all 8 times of amounts of medicinal materials；
（3）, be concentrated into relative density be 1.35 clear cream；Qinghuo reagent powder, plus 3.5 parts of sodium carboxymethyl starch and 0.3 part Magnesium stearate is always mixed, tabletting, is produced.
Film coating after tabletting, film clothing uses the premix coating agent of all materials total amount quality 3~5%.
The specification of tabletting is 0.6g/ pieces.
The consumption of the medicine is three every time, three times a day.
Clinical trial：
The clinical people's medication treatment of indigestion patient 6, wherein each 3 people of masculinity femininity, are divided into three groups, every group of two people；
Symptom：
First group：Early satiety, abdominal distension symptom；It is functional dyspepsia FD through clinical diagnosis；
Second group：Abdominal distension, there is stomachache；It is functional dyspepsia FD through clinical diagnosis；
3rd group：Stomachache, nausea, with symptoms of emesis；It is functional dyspepsia FD through clinical diagnosis；
Take the medicine of the present invention, three times a day, three every time：
Medication is two days later：
First group：Early satiety, abdominal distension symptom are relieved；
Second group：Two people's abdominal distension symptoms disappear, colic symptoms are alleviated；
3rd group：Two people's colic symptoms are alleviated, nausea is alleviated, symptoms of emesis disappears；
After medication four days：
First group：Two people's early satieties, abdominal distension symptom disappear, and clinical recommendation continues observation of taking one day；
Second group：One people is asymptomatic, and the slight colic symptoms of a people, the people of clinical recommendation two continues observation of taking one day；
3rd group：Two people's colic symptoms disappear, slight nausea；
After medication five days：
First group：Clinical diagnosis is recovery from illness, and does not occur symptom repeatedly；
Second group：Asymptomatic person has no that repeatedly slight colic symptoms person, which has no, to be relieved；
3rd group：One people's symptom disappears, and another people is with slight nausea；
After medication seven days：
First group：Clinical recovery, is repeatedly；
Second group：Remaining slight colic symptoms person, which has no, to be relieved, it is proposed that is admitted to hospital and is further examined, however not excluded that other devices Matter venereal disease becomes；
3rd group：Two people's symptoms disappear, and clinical diagnosis is recovery from illness；The group continues to take one day, and has no afterwards repeatedly.
Clinical side effects：
When taking medicine second day, there is slight dizziness in first group of one people, disappears within the 3rd day, but clinical data does not determine the disease Shape belong to clinical symptoms also have it is relevant with medicine, medication the 4th day when, there is skin itching symptom in second group of a patient, But clinical data does not show that the symptom and medicine have direct association.
In summary, the medicine has good curative effect for functional dyspepsia FD, and without obvious toxic-side effects.

Claims (7)

1. the medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated, it is characterised in that：The component that the medicine is divided by following quality It is prepared from：
100~135 parts of cardamom, 100~135 parts of fructus amomi, 100~135 parts of orange peel, 100~135 parts of pawpaw, hawthorn 130~165 Part, 100~135 parts of malt, interior golden 100~135 parts, 100~135 parts of ginger, 100~135 parts of Buddha's hand, Poria cocos 100~135 Part.
2. the medicine that a kind of function of spleen and stomach regulating function according to claim 1, promotion are digested and assimilated, it is characterised in that：Cardamom 120 parts, 120 parts of fructus amomi, 120 parts of orange peel, 120 parts of pawpaw, 150 parts of hawthorn, 120 parts of malt, interior golden 120 parts, 120 parts of ginger, 120 parts of Buddha's hand, 120 parts of Poria cocos.
3. preparing a kind of function of spleen and stomach regulating function described in claim 1, the method for the medicine that promotion is digested and assimilated, its feature exists In：This method step is as follows：Above-mentioned 10 taste medicinal material is taken to be extracted 1~3 hour with 4~8 times of amount water, filtering is concentrated into relative density For 1.2-1.35 clear cream；Qinghuo reagent powder, plus 2~3.5 parts of sodium carboxymethyl starch, 0.3~0.55 part of magnesium stearate be total Mixed, tabletting is produced.
4. preparation method according to claim 3, it is characterised in that：（1）, by cardamom, fructus amomi, orange peel and Nei Jin, grinding It is standby into 80 mesh powder, by pawpaw, ginger and Poria cocos be cut into the length of side be 0.5cm block it is standby, by hawthorn from axially break it is standby, will It is standby that Buddha's hand is cut into every section of 0.5cm；
（2）, will（1）The medicine of step is placed in container together with malt, is soaked 20~40 minutes, is then heated to and boils Boiling, is kept for 10~20 minutes, then separates fried liquid, and the dregs of a decoction are in accordance with the law repeatedly fried to amount to 1~3 hour used time, and decocting liquid is lightly seasoned to be Only, each fried liquid is merged, the consumption of water is the water of all 4~8 times of amounts of medicinal materials；
（3）, be concentrated into relative density be 1.2-1.35 clear cream；Qinghuo reagent powder, plus 2~3.5 parts of sodium carboxymethyl starch and 0.3~0.55 part of magnesium stearate is always mixed, and tabletting is produced.
5. the preparation method according to claim 3 or 4, it is characterised in that：Film coating after tabletting, film clothing uses property Expect the premix coating agent of total amount quality 3~5%.
6. the preparation method according to claim 3 or 4, it is characterised in that：The specification of tabletting is 0.6g/ pieces.
7. preparation method according to claim 6, it is characterised in that：The consumption of the medicine is three every time, three times a day.
CN201710467940.5A 2017-06-20 2017-06-20 Medicine that a kind of function of spleen and stomach regulating function, promotion are digested and assimilated and preparation method thereof Pending CN107184940A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101884772A (en) * 2009-05-15 2010-11-17 天津太平洋制药有限公司 Food therapy preparation for preventing and treating gastropathy based on theories of preventive treatment of disease and medicine food homology
CN102416124A (en) * 2011-11-21 2012-04-18 中山市中智药业集团有限公司 Medicinal application of particles formed by hawthorn and malt
CN104857484A (en) * 2015-06-01 2015-08-26 湖南中医药大学 Traditional Chinese medicine with effect of improving digestion and preparation method of traditional Chinese medicine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101884772A (en) * 2009-05-15 2010-11-17 天津太平洋制药有限公司 Food therapy preparation for preventing and treating gastropathy based on theories of preventive treatment of disease and medicine food homology
CN102416124A (en) * 2011-11-21 2012-04-18 中山市中智药业集团有限公司 Medicinal application of particles formed by hawthorn and malt
CN104857484A (en) * 2015-06-01 2015-08-26 湖南中医药大学 Traditional Chinese medicine with effect of improving digestion and preparation method of traditional Chinese medicine

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Application publication date: 20170922

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