CN107166876A - A kind of energy-efficient perindopril tert-butylamine piece particle drying technique - Google Patents
A kind of energy-efficient perindopril tert-butylamine piece particle drying technique Download PDFInfo
- Publication number
- CN107166876A CN107166876A CN201710336467.7A CN201710336467A CN107166876A CN 107166876 A CN107166876 A CN 107166876A CN 201710336467 A CN201710336467 A CN 201710336467A CN 107166876 A CN107166876 A CN 107166876A
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- Prior art keywords
- drying
- butylamine
- energy
- efficient
- batch
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B2200/00—Drying processes and machines for solid materials characterised by the specific requirements of the drying good
- F26B2200/08—Granular materials
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Abstract
The invention discloses a kind of energy-efficient perindopril tert-butylamine piece particle drying technique, comprise the following steps：(1), it is layered on the softwood made is loose in baking material disk, material thickness 1.5cm；(2), it is placed in heat-sealing circulation baking oven (CTC III) and dries, set 60 DEG C of drying temperature, turn over once within 1.5 hours after temperature stabilization, time 2 h to be dried and moisture reaches quality standards shutdowns, taking-up material.The thickness increase by 50% of material, can improve the amount of every batch of material drying, improve single batch inventory in the baking material disk of the present invention；The number of times that turns over is adjusted to once to turn over by original turning over twice, it is possible to reduce thermal loss, every batch of drying energy consumption reduction by 25%；By the holding to system heat in baking oven, drying time is reduced, single batch production is reduced time-consuming, it is to avoid personnel work extra shifts or extra hours situation.
Description
Technical field
The invention belongs to pharmaceutical industry, and in particular to a kind of energy-efficient perindopril tert-butylamine piece particle drying work
Skill.
Background technology
Drying process step on existing perindopril tert-butylamine piece particle is as follows：
1st, it is layered on the softwood made is loose in baking material disk, material thickness 1cm；
2nd, it is placed in heat-sealing circulation baking oven (CTC- III) and dries, sets 60 DEG C of drying temperature, 1 hour after temperature stabilization, 2 is small
When or so respectively turn over once, 2.5 hours time to be dried and moisture reach quality standards shutdown, take out material.
But problem present in above-mentioned processing step is as follows：
1st, existing heat-sealing circulation baking oven can put 144 disks, be limited by existing process, every batch of material drying is limited, it is impossible to full
Sufficient batch demand；
2nd, turned over twice according to existing process, because opening chamber door does stirring operation, have partial heat loss；
3rd, drying time is longer, can cause split run personnel, is worked extra shifts or extra hours in single batch of production process, can also increase equipment energy
Consumption burden；
4th, drying time is longer, and the pellet moisture made is relatively low, is unfavorable for follow-up sheeting process operation.
The content of the invention
Goal of the invention：In order to solve the deficiencies in the prior art, the invention provides a kind of energy-efficient Perindopril uncle
Butylamine piece particle drying technique.
Technical scheme：A kind of energy-efficient perindopril tert-butylamine piece particle drying technique, comprises the following steps：
(1), it is layered on the softwood made is loose in baking material disk, material thickness 1.5cm；
(2), it is placed in heat-sealing circulation baking oven (CTC- III) and dries, 60 DEG C of drying temperature is set, 1.5 hours after temperature stabilization
Turn over once, time 2 h to be dried and moisture reach quality standards shutdown, take out material.
Beneficial effect：The specific advantage of the present invention is as follows：
1st, the thickness of material increases by 50% in baking material disk of the invention, can improve the amount of every batch of material drying, improves single
Batch inventory；
2nd, the number of times that turns over is adjusted to once to turn over by original turning over twice, it is possible to reduce thermal loss, every batch of drying energy
Consumption reduction by 25%；
3rd, by the holding to system heat in baking oven, drying time is reduced, single batch production is reduced time-consuming, it is to avoid personnel
Work extra shifts or extra hours situation；
4th, the pellet moisture that former technique productions come out is relatively low, and often detection is less than 4% to moisture at the end of drying, and particle is partially dry
It is dry, it is unfavorable for follow-up sheeting process operation.
Brief description of the drawings
Fig. 1 is the material thickness comparative study figure in the present invention；
Fig. 2 is the number of times comparative study figure that turns in the present invention；
Fig. 3 is the follow-up optimal tabletting selection of speed figure of particle technique in the present invention.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, so that the technology of this area
Personnel can be better understood from advantages and features of the invention, so as to make apparent boundary to protection scope of the present invention
It is fixed.Embodiment described in the invention is only a part of embodiment of the invention, rather than whole embodiments, based on the present invention
In embodiment, the every other implementation that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
Embodiment
A kind of energy-efficient perindopril tert-butylamine piece particle drying technique, comprises the following steps：
(1), it is layered on the softwood made is loose in baking material disk, material thickness 1.5cm；
(2), it is placed in heat-sealing circulation baking oven (CTC- III) and dries, 60 DEG C of drying temperature is set, 1.5 hours after temperature stabilization
Turn over once, time 2 h to be dried and moisture reach quality standards shutdown, take out material.
The experimental study of the present invention is as follows：
1st, material thickness comparative study
Purpose：Whether research granulation process material thickness has an impact for product moisture
Analysis tool：Double sample T
Experimental method：According to present operating process, simulate often disk material 1cm and 1.5cm respectively with blank sample, turning over
Moisture situation at the end of parallel contrast experiment, measurement sample drying is done in the case of once.
Assuming that：
H0：μ (A)=μ (B)
H1:μ(A)≠μ(B)
α=0.05
Conclusion：As shown in figure 1, often disk charging has not significant impact for 1cm and 1.5cm for granular mass.
2nd, turn over number of times comparative study
Purpose：Whether research granulation process turns over once has an impact for product moisture twice with turning over
Analysis tool：Double sample T
Experimental method：According to present operating process, the co-dried 2.5h of granulation process heated-air circulation oven turns over twice respectively
(1h, 2h), is simulated and turns over once (1.5h) with twice, being parallel contrast experiment, measure sample drying knot respectively with blank sample
Moisture situation during beam.
Assuming that：
H0：μ (A)=μ (B)
H1:μ(A)≠μ(B)
α=0.05
Conclusion：As shown in Fig. 2 turn over once does not have significant difference with the moisture twice that turns over
3rd, the follow-up optimal tabletting selection of speed of particle technique
Purpose：Tablet weight variation when studying tablet press machine rotating speed difference
Analysis tool：Monodrome control figure
Experimental method：Dried using technique after improvement, it is respectively 14 turns in tablet press machine rotating speed to take particle after drying, 15 turns,
16 turns, at 17 turns, adjustment sheet weight is to 70mg, under normal operation, samples 40, measures piece weight.
Conclusion, as shown in figure 3, by comparative analysis, when rotating speed is 15 turns, piece weight is most stable.During normal production operation, turn
Speed can be in the range of 14-16.
Claims (1)
1. a kind of energy-efficient perindopril tert-butylamine piece particle drying technique, it is characterised in that：Comprise the following steps：
(1), it is layered on the softwood made is loose in baking material disk, material thickness 1.5cm；
(2), it is placed in heat-sealing circulation baking oven (CTC- III) and dries, sets 60 DEG C of drying temperature, turn within 1.5 hours after temperature stabilization
Once, time 2 h to be dried and moisture reach quality standards shutdown, take out material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336467.7A CN107166876A (en) | 2017-05-13 | 2017-05-13 | A kind of energy-efficient perindopril tert-butylamine piece particle drying technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336467.7A CN107166876A (en) | 2017-05-13 | 2017-05-13 | A kind of energy-efficient perindopril tert-butylamine piece particle drying technique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107166876A true CN107166876A (en) | 2017-09-15 |
Family
ID=59816523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710336467.7A Pending CN107166876A (en) | 2017-05-13 | 2017-05-13 | A kind of energy-efficient perindopril tert-butylamine piece particle drying technique |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107166876A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861080A (en) * | 2014-03-20 | 2014-06-18 | 东英（江苏）药业有限公司 | Efficient perindopril tablet and production process thereof |
| CN103977086A (en) * | 2014-04-25 | 2014-08-13 | 贵州三泓药业股份有限公司 | Preparation method of polygonum capitatum instant powder |
| CN105153245A (en) * | 2015-09-23 | 2015-12-16 | 河南正弘药用辅料有限公司 | Production technology for medicinal cane sugar |
| CN105707569A (en) * | 2014-12-01 | 2016-06-29 | 哈尔滨墨医生物技术有限公司 | Chewing tablet capable of enhancing bone mineral density and supplementing vitamin D as well as production method thereof |
-
2017
- 2017-05-13 CN CN201710336467.7A patent/CN107166876A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861080A (en) * | 2014-03-20 | 2014-06-18 | 东英（江苏）药业有限公司 | Efficient perindopril tablet and production process thereof |
| CN103977086A (en) * | 2014-04-25 | 2014-08-13 | 贵州三泓药业股份有限公司 | Preparation method of polygonum capitatum instant powder |
| CN105707569A (en) * | 2014-12-01 | 2016-06-29 | 哈尔滨墨医生物技术有限公司 | Chewing tablet capable of enhancing bone mineral density and supplementing vitamin D as well as production method thereof |
| CN105153245A (en) * | 2015-09-23 | 2015-12-16 | 河南正弘药用辅料有限公司 | Production technology for medicinal cane sugar |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170915 |
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| RJ01 | Rejection of invention patent application after publication |