CN107163316A - A kind of Medical sterilization isoprene rubber plug and preparation method thereof - Google Patents
A kind of Medical sterilization isoprene rubber plug and preparation method thereof Download PDFInfo
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- CN107163316A CN107163316A CN201710397872.XA CN201710397872A CN107163316A CN 107163316 A CN107163316 A CN 107163316A CN 201710397872 A CN201710397872 A CN 201710397872A CN 107163316 A CN107163316 A CN 107163316A
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- medical
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- extract
- isoprene rubber
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L9/00—Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
The invention provides a kind of Medical sterilization isoprene rubber plug and preparation method thereof.The rubber stopper is prepared by following component and constituted：Butyl rubber, isoprene rubber, medical zinc oxide, medical zinc stearate, medical antiaging agent, titanium dioxide, mineral oil, the benzothiazolyl sulfenamide of N cyclohexyl 2, the carboxylic acid sodium of 2 pyrrolidones 5, activated zinc oxide, calcined kaolin, fruit of a cubeb litsea tree extract and corter pseudolaricis extract, are prepared from by mixing, calendering formation, vulcanization, sterilizing, drying process.The Medical sterilization isoprene rubber plug of the present invention uses artificial isoprene, it can avoid and be caused allergic reaction because natural rubber contains the materials such as plant rennet, medical calcined kaolin is used simultaneously, the resistance to punctural of rubber stopper can be improved, fruit of a cubeb litsea tree extract, corter pseudolaricis extract are finally used, makes rubber stopper that there is good bactericidal property.
Description
Technical field
The present invention relates to a kind of Medical sterilization isoprene rubber plug, belong to medical equipment field.
Background technology
Medicinal rubber stopper be directly with drug contact with seal-packed special rubber, therefore to its performance,
Particularly chemical property requires more strict.Nowadays more than 90 percent medical packaging rubber stopper is with butyl in the world
Rubber is what base material was produced, and medical packaging rubber stopper butylation turned into it is global it is preferred and irreversible become
Gesture, but butyl rubber stoppers still suffer from some problems in application aspect, what performance was more protruded is puncture problem, to avoid doctor
Treat dispute, it is ensured that clinical application safety, improve butyl rubber stoppers puncture fall performance it is very necessary；In addition in medical row
In industry, typically have as conduit, plug and cosmetically, this requires material non-toxic, good with biocompatible, does not produce secondary
Pollution, but existing plug product is difficult to meet these important function, and some changes need to be made on formula and preparation technology.
The content of the invention
It is an object of the invention to provide a kind of Medical sterilization isoprene rubber plug and preparation method thereof, rubber stopper tool
There are preferable resistance to acupuncture performance and bactericidal property.
To achieve the above object, the present invention provides following technical scheme：A kind of Medical sterilization isoprene rubber plug, it is described
Sterilization be made up with isoprene rubber plug of following raw material：12-16 parts of butyl rubber, isoprene rubber 90-120
Part, medical zinc oxide 2-7 parts, medical zinc stearate 1-4 parts, medical antiaging agent 4-6 parts, 6-10 parts of titanium dioxide, mineral oil
For 10-20 parts, it is N- cyclohexyl -2-4 parts of 2-[4-morpholinodithio base sulfenamide, 0.1-0.6 parts of 2-Pyrrolidone -5- carboxylic acid sodiums, living
2-7 parts of zinc oxide of property, 70-85 parts of calcined kaolin.
Further, a kind of raw material of Medical sterilization isoprene rubber plug also includes fruit of a cubeb litsea tree extract 1-2
Part, 1-2 parts of corter pseudolaricis extract.
A kind of preparation method of above-mentioned Medical sterilization isoprene rubber plug, comprises the following steps：
（1）The fruit of a cubeb litsea tree, corter pseudolaricis pulverizing medicinal materials are taken, are extracted with 80% alcohol reflux, medicinal extract uses petroleum ether, chloroform, acetic acid second respectively
Ester is extracted, and obtains after active site, its chemical composition is separated using silica gel column chromatography, purified, and obtains the fruit of a cubeb litsea tree, the native rose of Sharon
Bark extract；
（2）Essential Oil of Acorus tatarinowii, extracting pressure 18-22MPa, 50-60 DEG C of extraction temperature, CO2 streams are obtained using SCF-CO 2
Measure as 50-60kg/h, extraction time 2-3h, obtain calamus extract；
（3）Dosage requirement by rubber stopper is made weighs butyl rubber, isoprene rubber, medical zinc oxide, medical stearic acid
Zinc, medical antiaging agent, titanium dioxide, mineral oil, N- cyclohexyl -2-[4-morpholinodithio base sulfenamide, 2-Pyrrolidone -5- carboxylics
Sour sodium, activated zinc oxide, calcined kaolin, fruit of a cubeb litsea tree extract, corter pseudolaricis extract, and be well mixed；
（4）Well mixed raw material is put into banbury and kneaded, temperature is 80-100 DEG C, and the time is 15-18min, is mixed
Refining glue inputs calender calendering formation；
（5）Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115-125 DEG C, and the time is 15-20min, vulcanization
Trimming is carried out to semi-finished product afterwards, cleaned, sterilizing is dried to obtain finished product.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention use artificial isoprene, can avoid because
Natural rubber contains the materials such as plant rennet and this rubber stopper simultaneously that causes allergic reaction, while using medical calcining kaolinite
Soil, can improve the resistance to punctural of rubber stopper, finally using fruit of a cubeb litsea tree extract, corter pseudolaricis extract, have rubber stopper fine
Bactericidal properties.
Embodiment
The invention will be further elucidated with reference to specific embodiments.
Embodiment 1
A kind of Medical sterilization isoprene rubber plug, is made up of following raw material：12 parts of butyl rubber, isoprene rubber
90 parts, 4 parts of medical zinc oxide, 2 parts of medical zinc stearate, 4 parts of medical antiaging agent, 6 parts of titanium dioxide, mineral oil be 10 parts,
N- cyclohexyl -2 parts of 2-[4-morpholinodithio base sulfenamide, 0.1 part of 2-Pyrrolidone -5- carboxylic acid sodiums, 3 parts of activated zinc oxide, calcining
70 parts of kaolin.
A kind of above-mentioned Medical sterilization isoprene rubber plug preparation method is：（1）1 part takes the fruit of a cubeb litsea tree, corter pseudolaricis respectively
Pulverizing medicinal materials, are extracted with 80% alcohol reflux, and medicinal extract is extracted with petroleum ether, chloroform, ethyl acetate respectively, is obtained after active site,
Its chemical composition is separated using silica gel column chromatography, purified, the fruit of a cubeb litsea tree, corter pseudolaricis extract is obtained；（2）Using overcritical
CO2 extracts to obtain Essential Oil of Acorus tatarinowii, extracting pressure 18MPa, 50-60 DEG C of extraction temperature, and CO2 flows are 50kg/h, extraction time
2h, obtains calamus extract；（3）Dosage requirement by rubber stopper is made weighs butyl rubber, isoprene rubber, medical oxidation
Zinc, medical zinc stearate, medical antiaging agent, titanium dioxide, mineral oil, N- cyclohexyl -2-[4-morpholinodithio base sulfenamide, 2-
Pyrrolidone-5-carboxylic acid sodium, activated zinc oxide, calcined kaolin, fruit of a cubeb litsea tree extract, corter pseudolaricis extract, grass-leaved sweetflag volatilization
Oil, and be well mixed；（4）Well mixed raw material is put into banbury and kneaded, temperature is 100 DEG C, and the time is 18min, is obtained
Calender calendering formation is inputted to elastomeric compound；（5）Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115 DEG C,
Time is 120min, and trimming is carried out to semi-finished product after vulcanization, is cleaned, and sterilizing is dried to obtain finished product.
Embodiment 2
A kind of Medical sterilization isoprene rubber plug is made up of following raw material：14 parts of butyl rubber, isoprene rubber
100 parts, 5 parts of medical zinc oxide, 4 parts of medical zinc stearate, 5 parts of medical antiaging agent, 8 parts of titanium dioxide, mineral oil be 15 parts,
N- cyclohexyl -4 parts of 2-[4-morpholinodithio base sulfenamide, 0.2 part of 2-Pyrrolidone -5- carboxylic acid sodiums, 4 parts of activated zinc oxide, calcining
75 parts of kaolin；
A kind of above-mentioned Medical sterilization isoprene rubber plug preparation method is：（1）1 part takes the fruit of a cubeb litsea tree, corter pseudolaricis medicinal material respectively
Crush, extracted with 80% alcohol reflux, medicinal extract is extracted with petroleum ether, chloroform, ethyl acetate respectively, is obtained after active site, is used
Silica gel column chromatography is separated to its chemical composition, purified, and obtains the fruit of a cubeb litsea tree, corter pseudolaricis extract；（2）Using supercritical CO 2
Extract to obtain Essential Oil of Acorus tatarinowii, extracting pressure 18MPa, 50-60 DEG C of extraction temperature, CO2 flows are 50kg/h, extraction time 2h,
Obtain calamus extract；（3）Dosage requirement by rubber stopper is made weigh butyl rubber, isoprene rubber, medical zinc oxide,
Medical zinc stearate, medical antiaging agent, titanium dioxide, mineral oil, N- cyclohexyl -2-[4-morpholinodithio base sulfenamide, 2- pyrroles
Pyrrolidone -5- carboxylic acid sodiums, activated zinc oxide, calcined kaolin, fruit of a cubeb litsea tree extract, corter pseudolaricis extract, Essential Oil of Acorus tatarinowii,
And be well mixed；（4）Well mixed raw material is put into banbury and kneaded, temperature is 100 DEG C, and the time is 18min, is mixed
Refining glue inputs calender calendering formation；（5）Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115 DEG C, time
For 120min, trimming is carried out to semi-finished product after vulcanization, cleaned, sterilizing is dried to obtain finished product.
Although the embodiment to the present invention gives detailed description and illustrated above, it should be noted that
We can carry out various equivalent changes and modification according to the conception of the present invention to above-mentioned embodiment, and the function produced by it is made
, all should be within protection scope of the present invention during with the spirit still covered without departing from specification.
Claims (3)
1. a kind of Medical sterilization isoprene rubber plug, it is characterised in that described sterilization is with isoprene rubber plug by following
Raw material is made：12-16 parts of butyl rubber, 90-120 parts of isoprene rubber, medical zinc oxide 2-7 parts, medical tristearin
Sour zinc 1-4 parts, medical antiaging agent 4-6 parts, 6-10 parts of titanium dioxide, mineral oil be 10-20 parts, N- cyclohexyl -2- benzo thiophenes
2-4 parts of oxazolyl sulfenamide, 0.1-0.6 parts of 2-Pyrrolidone -5- carboxylic acid sodiums, 2-7 parts of activated zinc oxide, calcined kaolin 70-
85 parts.
2. a kind of Medical sterilization isoprene rubber plug according to claim 1, it is characterised in that：Also carried including the fruit of a cubeb litsea tree
Take 1-2 parts of thing, 1-2 parts of corter pseudolaricis extract.
3. a kind of preparation method of Medical sterilization isoprene rubber plug, it is characterised in that comprise the following steps：
（1）The fruit of a cubeb litsea tree, corter pseudolaricis pulverizing medicinal materials are taken, are extracted with 80% alcohol reflux, medicinal extract uses petroleum ether, chloroform, acetic acid second respectively
Ester is extracted, and obtains after active site, its chemical composition is separated using silica gel column chromatography, purified, and obtains the fruit of a cubeb litsea tree, the native rose of Sharon
Bark extract；
（2）Essential Oil of Acorus tatarinowii, extracting pressure 18-22MPa, 50-60 DEG C of extraction temperature, CO2 streams are obtained using SCF-CO 2
Measure as 50-60kg/h, extraction time 2-3h, obtain calamus extract；
（3）Dosage requirement by rubber stopper is made weighs butyl rubber, isoprene rubber, medical zinc oxide, medical stearic acid
Zinc, medical antiaging agent, titanium dioxide, mineral oil, N- cyclohexyl -2-[4-morpholinodithio base sulfenamide, 2-Pyrrolidone -5- carboxylics
Sour sodium, activated zinc oxide, calcined kaolin, fruit of a cubeb litsea tree extract, corter pseudolaricis extract and calamus extract, and be well mixed；
（4）Well mixed raw material is put into banbury and kneaded, temperature is 80-100 DEG C, and the time is 15-18min, is mixed
Refining glue inputs calender calendering formation；
（5）Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115-125 DEG C, and the time is 15-20min, vulcanization
Trimming is carried out to semi-finished product afterwards, cleaned, sterilizing is dried to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710397872.XA CN107163316A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical sterilization isoprene rubber plug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710397872.XA CN107163316A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical sterilization isoprene rubber plug and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107163316A true CN107163316A (en) | 2017-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710397872.XA Pending CN107163316A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical sterilization isoprene rubber plug and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108003403A (en) * | 2017-12-20 | 2018-05-08 | 王维维 | A kind of rubber of Medical rubber plug and preparation method thereof |
| CN111171422A (en) * | 2020-02-21 | 2020-05-19 | 郑州华净新材料科技有限公司 | Piston for pre-filling and sealing injector and manufacturing method thereof |
| CN114230877A (en) * | 2021-12-24 | 2022-03-25 | 湖北华强科技股份有限公司 | Blending system and mixing process of isoprene rubber and brominated butyl rubber |
-
2017
- 2017-05-31 CN CN201710397872.XA patent/CN107163316A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108003403A (en) * | 2017-12-20 | 2018-05-08 | 王维维 | A kind of rubber of Medical rubber plug and preparation method thereof |
| CN111171422A (en) * | 2020-02-21 | 2020-05-19 | 郑州华净新材料科技有限公司 | Piston for pre-filling and sealing injector and manufacturing method thereof |
| CN111171422B (en) * | 2020-02-21 | 2022-04-12 | 郑州华净新材料科技有限公司 | Piston for pre-filling and sealing injector and manufacturing method thereof |
| CN114230877A (en) * | 2021-12-24 | 2022-03-25 | 湖北华强科技股份有限公司 | Blending system and mixing process of isoprene rubber and brominated butyl rubber |
| CN114230877B (en) * | 2021-12-24 | 2023-11-28 | 湖北华强科技股份有限公司 | Blending system and mixing process of isoprene rubber and brominated butyl rubber |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170915 |
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| WD01 | Invention patent application deemed withdrawn after publication |