CN107149524A - Intelligent sanitary sliver - Google Patents
Intelligent sanitary sliver Download PDFInfo
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- CN107149524A CN107149524A CN201710336782.XA CN201710336782A CN107149524A CN 107149524 A CN107149524 A CN 107149524A CN 201710336782 A CN201710336782 A CN 201710336782A CN 107149524 A CN107149524 A CN 107149524A
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- Prior art keywords
- chip
- probe
- blood
- tapon
- thorn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2002—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the use
- A61F13/202—Catamenial tampons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F2013/8473—Accessories, not otherwise provided for, for absorbent pads for diagnostic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F2013/8488—Accessories, not otherwise provided for, for absorbent pads including testing apparatus
- A61F2013/8491—Accessories, not otherwise provided for, for absorbent pads including testing apparatus including test methods
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention belongs to amenities technical field, more particularly to a kind of Intelligent sanitary sliver, including tapon body, the power module being electrically connected with tapon body provided with intellectual monitoring module and with intellectual monitoring module, intellectual monitoring module includes blood examination chip, sensor, data acquisition module and the wireless communication module for transmitting gathered data to intelligent terminal；Blood examination chip includes carrier substrate, the conductive substrate located at carrier substrate and is covered in the insulation glue-line of conductive substrate, insulation glue-line offers probe through hole, probe through hole is provided with the nano metal probe for protruding from insulation film surface, nano metal probe includes metal probe body and is distributed in the thorn-like projection of metal probe body surface, and thorn-like is raised and its surrounding is attached with the antibody molecule for detecting pathogen.The present invention effectively monitors the health data of women physiological period using tapon, allows women to know the health status of itself in time, eliminates the trouble that hospital takes a blood sample.
Description
Technical field
The invention belongs to amenities technical field, more particularly to a kind of Intelligent sanitary sliver.
Background technology
Tapon, also known as tampon, are a kind of cylinders of cotton, the time of tide are carried out in feminine menstrual, can insert in vagina
Absorb menstrual blood.Compared to sanitary napkin, lateral leakage of menstrual blood is less likely to occur due to being to insert intravaginal for tapon, also will not
There is the situation that sanitary napkin flank and two legs produce friction and do not felt well, but also women can be allowed still to join in menstrual period
Plus swimming etc. underwater movement.Existing tapon is generally divided into finger-operated and catheter type, but either finger-operated or conduit
Formula tapon all includes absorber and is located at the extraction rope of absorber end, except that, finger-operated tapon makes
Used time is needed to be aided in finger, and tapon is inserted into intravaginal；And catheter type tapon is first to be placed in tapon
In conduit, tapon can be inserted into intravaginal by conduit when in use, use more convenient and health.And changing
Or when abandoning tapon, need to only pull extraction rope can extract tapon out external, and therefore, tapon uses phase
When convenient.
But in view of the generality of the diseases such as gynaecological imflammation, existing tapon is not improved to the problem,
Improvement to material and in shape is rested on mostly so that the existing product function is single on the market, it is impossible to learn user
Physical condition, therefore, be badly in need of a kind of full-featured and easy to use tapon of research and development.
Research shows that the female ratio now with all kinds of gynecological diseases accounts for 73%, and more or less all can in life
With different degrees of gynaecological imflammation；In change of the townie women due to operating pressure and living environment, reproductive system
Cancer morbidity than 20 years before rise by about one time, and in rejuvenation trend.The threat of various diseases, the serious women that reduces is good for
Health composite index.Thus medical expert points out early discovery, and early treatment is the unique channel for preventing malignant disease, more than 18 years old women
A healthy reproduction inspection should be at least done every year.However, due to being busy with one's work, a variety of causes such as somewhat expensive, it is daily few
Women can actively arrive hospital and carry out routine physical examination.Therefore under normal circumstances, it is most of to cause menalgia or gynaecology
The problem of disease, is all difficult to discover.Such as, women suffers from gonorrhoea or when Chlamydia infects, the disease that all You nothing obvious
Shape, generally golden hour has been had already passed by when finding；But if these bacterial numbers are in female reproductive system
In constantly rise if, it is more likely that cause pelvic infecton, so as to further result in the health problems such as female infertility.
It is well known that blood is flowed in heart and endovascular opaque red liquid, main component is blood plasma, blood is thin
Three kinds of born of the same parents and blood platelet.Haemocyte is divided into red blood cell and leucocyte again.In blood contain various nutritional ingredients, such as inorganic salts, oxygen,
Metabolite, hormone, enzyme and antibody etc., nutritious tissue, regulation organ activity and the effect for defending harmful substance.Each device of human body
The physiology of official and pathological change, often cause the change of blood constituent, therefore are often required to diagnose the illness by blood count after illness.
Menstruation is that about monthly, the menorrhea amount of general women is 30~50ml because property endometrial cycle comes off with bleeding,
Normal menses are in alkaline, color is dark red, odorless, and sticky without solidifying, menses are in addition to blood constituent, also containing endometrium
Fragment, Ovulation prediction and the vaginal epithelial cell that comes off etc..Refer to the color of menstrual blood through color, normal menstrual blood is general in dark
Red, it is shallower to start color, gradually deepens later, last to switch to pale red again and clean.Refer to the character of menstrual blood through matter, normally
In the case of it is not dilute not thick through matter, be difficult solidification, without obvious clot, no special odor.But, the menses of some women are with different
Taste, what is had is very big through blood volume, may suffer from fibroid, metropolypus, endometriosis and dysthyroid；
Have through blood volume very little, it may be possible to caused by dysfunctional uterine bleeding, Stein-Leventhal syndrome, premature ovarian failure etc..Always
It, menstrual blood is exactly the barometer of female reproductive system, objectively reflects very much the health condition of women.
Regrettably, up to the present still without a set of continuous, complete detection system set up for feminine menstrual blood
System and examination criteria, generally, female friend due to shy and painful topic, until reproductive system it is ill it is very serious after
Go to a hospital to see a doctor, but be now already belonging to treatment stage, not the transition in routine testing and protection stage；And due to hospital
Policy issue and administrative region limitation, it is impossible to set up large-scale broad spectrum activity reproductive system pathological data group, and because hospital is
Profit based organisations, the continuous long-term menstrual blood of personal implementation that is directed to that will not be gratuitously detects and sets up corresponding management system.
That is, menstrual blood is a fabulous blood testing sample in fact, menstrual blood realization pair can be utilized completely
The disease detection work of women.Therefore, it is necessory to research and develop a both safety and comfort, it is easy to use, and menstrual blood pair can be utilized
The Intelligent sanitary sliver that the health status of women is detected and monitored.
The content of the invention
It is an object of the invention to：It is single for existing tapon function, in-convenience in use deficiency, and provide a kind of
Both safety and comfort, easy to use, and the Intelligent sanitary cotton that the health status of women can be detected and monitored using menstrual blood
Bar.
To achieve the above object, the present invention is adopted the following technical scheme that：
Be provided with a kind of Intelligent sanitary sliver, including tapon body, the tapon body intellectual monitoring module, with
And the power module being electrically connected with intellectual monitoring module, the intellectual monitoring module is including that can detect the blood examination core of menses
Piece, the sensor that tapon internal environment can be monitored, the number being electrically connected with respectively with the blood examination chip and the sensor
The wireless communication module transmitted according to acquisition module and by gathered data to intelligent terminal；The blood examination chip includes carrier base
Piece, the conductive substrate for being arranged at the carrier substrate and the insulation glue-line for being covered in the conductive substrate, the insulation glue-line
Probe through hole is offered, the probe through hole is provided with the nano metal probe for protruding from insulation film surface, the nanogold
Category probe includes metal probe body and is distributed in the thorn-like projection of metal probe body surface, and the thorn-like is raised and its all
The antibody molecule for being attached with detection pathogen is enclosed, the antibody molecule is in DNA molecular, RNA molecule and immobilised enzymes molecule
It is at least one.
Wherein, the blood examination chip can carry out real-time menses inspection, can be given within several minutes even several seconds
Go out menses testing result.So as to allow user to know the health status of oneself in time, to carry out timely prevention from suffering from the diseases
Or treatment, while eliminating the trouble that hospital is taken a blood sample, this highly shortened the interval between detection and treatment
Time so that user can quickly, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination
Chip causes detection more convenient, more efficient.
In addition, the present invention can monitor the internal environment of tapon by temperature and moisture sensors, and pass through intelligence
Terminal reminds user to change tapon in the suitable time；Moreover, it is also possible to by setting the sensor of difference in functionality to know
The physiological datas such as the color of other menses, pH value, and bacterial concentration, and the data of collection are sent to intelligence by wireless communication module
Energy terminal, the physiological status of user is relatively can be inferred that by carrying out data analysis, if it find that physiology is incited somebody to action when having exception
User can be reminded to go examination in hospital to treat in time, full-scope safeguards women's health.
The Cleaning Principle of blood examination chip is in the present invention：Attract and capture to deposit in through blood sample by antibody molecule
Pathogen molecule, and nano metal probe is then equivalent to microsensor, when the antibody molecule and cause of disease that are attached to its surface
When body molecule is combined, nano metal probe can produce electric current, and pathogen molecule is determined according to the power of the electric current of generation
Type.
Because all DNA fragmentations have excellent characteristics, optionally can closely it be tied with another segment DNA fragment
Close.For example, the antibody molecule by designing and synthesizing high degree of specificity, the antibody molecule is attached on nano metal probe,
The DNA molecular of staphylococcus aureus present in menses is caught with this, when the antibody molecule and the DNA of staphylococcus aureus
When molecule is combined, nano metal probe will produce electric current.
In addition, immobilised enzymes molecule can also be adhered in the present invention to detect the component target in menses, such as in nanometer
Adhere to the glucose oxidase of solidification on metal probe, for measuring the concentration of glucose in blood；On nano metal probe
Adhere to the LO of solidification, for measuring the concentration of lactic acid in blood；The courage for adhering to solidification on nano metal probe is consolidated
Alcohol oxidase and cholesterol ester hydrolase, for measuring the concentration of Blood Cholesterol；Adhere to solidification on nano metal probe
B- HBDs and reducibility coenzyme, for measuring the concentration of ketoboidies in blood.Its principle is that these immobilised enzymes divide
With the material such as the blood glucose in blood, cholesterol, lactic acid, ketoboidies redox reaction occurs for son respectively, produces oxidation current, therefore
The concentration of the materials such as Blood Glucose, cholesterol, lactic acid and ketoboidies can be determined by the size for measuring electric current.
It should be noted that the present invention can set multiple nano metal probe structures on the surface of carrier substrate, every
Different types of antibody molecule is adsorbed on individual nano metal probe.So, as soon as only needing bleed sample, energy on blood examination chip
Multiple pathogens are analyzed, and most methods are once only capable of detecting a kind of pathogen molecule.
Inventor has found that a drop is through the quantity levels of pathogen molecule in blood sample and doctor's syringe needle in research process
The blood sample of taking-up is suitable.In this case, a pathogen molecule of the drop through blood sample is typically less than 1000, even
Less.Even if having adjusted the quantity of pathogen molecule, its quantity in through blood sample is set to reach million ranks, the electricity detected
Flow signal also fainter.Pass through the peptizaiton that thorn-like is raised so that have bigger space around antibody molecule, carry disease
The liquid of substance molecule flows through these spaces and is also easier to, so, and antibody molecule and pathogen molecule also just have much more machine
It can be in contact with each other, so as to effectively improve sensitivity and the accuracy of detection.
Improved as one kind of Intelligent sanitary sliver of the present invention, the thorn-like is raised and its surrounding is also attached with metallic molecule
Ruthenium.Wherein, metallic molecule ruthenium because ruthenium carries the positive charge of a unit, therefore can be adsorbed equivalent to the effect of amplifier
On pathogen molecule with a negative electrical charge；So, the complex of ruthenium and pathogen molecule is easy to from nano metal probe
On seize electronics, so as to produce one electric current for being enough to detect.
Improved as one kind of Intelligent sanitary sliver of the present invention, the metal probe body includes being arranged in probe through hole
Metal cartridge, and protrude from the hemispherical metallic substrates of insulation film surface, the thorn-like projection is distributed in the hemisphere
The surface of shape metallic substrates.Compared to square structure, the surface of metal probe body is designed to hemispherical dome structure, so can
Be effectively increased the surface area of metal probe, so as to be more beneficial for follow-up thorn-like raised " growth ", and antibody molecule attachment
With it is scattered.
Improved as one kind of Intelligent sanitary sliver of the present invention, the raised height of the thorn-like is 1 ~ 100nm.If thorn-like is convex
The height risen is too small, then can not play a part of effectively disperseing antibody molecule；If the raised height of thorn-like is excessive, disperse antibody point
Sub- effect does not increase anti-drop, so can not only increase manufacturing cost, while can increase the volume of whole blood examination chip yet.
Improved as one kind of Intelligent sanitary sliver of the present invention, the preparation method of the blood examination chip comprises the following steps：
Step 1: carrying out surface cleaning processing to carrier substrate, conductive substrate and photoresist layer are then coated successively, then in purple
It is exposed and develops under the irradiation of outer light, and unexposed conductive substrate is removed using metal etchants, with needed for is formed
Circuitous pattern；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line that insulate is then coated with, and insulation glue-line is entered
Row gets through hole processing, obtains the chip substrate of the through hole containing probe；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, electricity is carried out to probe through hole
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
Raised nano metal probe；
Step 5: thorn-like it is raised and its around load detecting pathogen antibody molecule, be then packaged processing, that is, obtain
Described blood examination chip.
Wherein, carrier substrate is silicon chip, graphene substrate or silicon carbide substrate, and it is excellent chip carrier, is
High-precision blood examination chip provides important foundation；Insulation glue-line then plays insulation passivation, in order to nano metal probe
Make；The conduction and detection connection of conductive substrate then for electric current.
It should be noted that in blood examination chip fabrication processes, the time of plating is crucial, if the overlong time of plating,
The raised metal probe structure of thorn-like containing nanometer can not just be obtained；But the time of plating is too short, and metal probe structure just arrives nanometer
Level just stops " growth ", can not equally obtain required nano metal probe.In addition, the control to electroplating voltage/electric current is also
Of crucial importance, otherwise, electroplating voltage/electric current is too high or too low can not also to obtain required nano metal probe.
Improved as one kind of Intelligent sanitary sliver of the present invention, metal salt solution is by HAuCl described in step 34And HCl
By volume 1：（1~10）Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration is 10 ~ 500mmol/
L.Gold is the good conductor of electric current, therefore, and selection Nano-Au probe can effectively improve sensitivity and the accuracy of detection.
Improved as one kind of Intelligent sanitary sliver of the present invention, the tapon body includes absorber, the absorption
The surface of body is provided with guiding gutter, and one end of the absorber extracts rope out provided with least one.Wherein, absorber is in the form of a column, one
As formed using cotton or staple fibre compacting, settings of guiding gutter contributes to length direction of the menses along absorber to be distributed, and takes out
Rope stretching is easy to take out the absorber for being filled menses from intravaginal.It should be noted that tapon originally can also be set in vitro
Conduit formation catheter type tapon, so by tapon can insert intravaginal by conduit, be inserted compared to finger
It is more convenient, relatively sanitary.
Improved as one kind of Intelligent sanitary sliver of the present invention, the intellectual monitoring module is by way of placing or being implanted into
It is placed in the absorber.The blood clot that menstrual blood contains can so be filtered out by absorbing surface layer, equivalent to menstruation
Blood is purified, and prevents from influenceing the testing result of blood examination chip.
Improved as one kind of Intelligent sanitary sliver of the present invention, the sensor is temperature sensor, humidity sensor, stream
At least one of quantity sensor, pressure sensor and heat-sensitive sensor.Its main function is to privates environment and to menstrual blood
The analysis and detection of physiological data.
As Intelligent sanitary sliver of the present invention one kind improve, the wireless communication module be bluetooth, RFID, Z-wave,
At least one of HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi.
Improved as one kind of Intelligent sanitary sliver of the present invention, the intellectual monitoring module also includes physical therapy chip, described
Physical therapy chip is at least one in magnetic therapy chip, negative ion chip, Nano Silver chip, far infrared chip and activated carbon chip
Kind.By setting one or more of different physical therapy chips, such as the magnetic therapy chip with healthcare function, this magnetic can be set
Property material magnetostatic field, biological magnetic is produced when with human contact, magnetic energy is supplemented, body local microcirculation can be promoted, is improved
Biology enzyme increases, and increases the acidic materials of vaginal fluid, the magnetic therapy chip is typically made up of neodymium-iron-boron magnetic material, and carries out
Appropriate magnetizes.Further, it is also possible to set anion, far infrared, Nano Silver, activated carbon etc have anti-inflammatory or sterilization work(
The chip of energy.Wherein, multiple chips can be that function is consistent or combination of difference in functionality, the main alleviation that can calm
The intense strain of female menstrual period, evades menstruation infection, goes to eliminate the unusual smell, and with bactericidal antiphlogistic effect, during so as to female pathology
Phase builds comfortable, pleasure a mental state.Therefore, physical therapy chip of the present invention can effectively alleviate the lower abdomen pain of menstrual period appearance
Bitterly, falling inflation；And compared to drug therapy, the setting of physical therapy chip can promote female body local microcirculation system, improve
Biology enzyme increases, increase and the acidic materials for maintaining vaginal fluid, maintains the balance of microcirculqtory system so that of the invention sets
Meter more cares about the health of women.
Improved as one kind of Intelligent sanitary sliver of the present invention, the intelligent terminal is connected with cloud server, the intelligence
Energy terminal is at least one of mobile phone, computer and wearable device.By the present invention in that intelligent terminal connects with cloud server
Connect, so as to set up individual database, can be so in the future fixed by each data Cun Chudao cloud servers for gathering and analyzing
The personalized tapon of system and medical diagnosis on disease provide important references.
The beneficial effects of the present invention are：The present invention does not only have the function of general tapon and merges advanced electronics
Science and technology, menses detection knot can be provided by the intrinsic blood examination chip of tapon within several minutes even several seconds
Really, and testing result can be sent to intelligent terminal by radio communication in time, obtains the interpretation of result of specialty, used so as to allow
Person can know the health status of oneself in time, to carry out timely prevention from suffering from the diseases or treatment；Eliminate simultaneously and usually arrive doctor
The trouble that institute is taken a blood sample, this highly shortened the interval time between detection and treatment so that user can be fast
Speed, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination chip make it that detection is more convenient, more
Efficiently；In addition, the present invention can monitor the internal environment of tapon by temperature and moisture sensors, and pass through intelligent terminal
User is reminded to change tapon in the suitable time；Moreover, it is also possible to be passed through by setting the sensor of difference in functionality to recognize
The physiological datas such as the color of blood, pH value, and bacterial concentration, and the data of collection are sent to intelligent end by wireless communication module
End, the physiological status of user is relatively can be inferred that by carrying out data analysis, will be carried during exception if it find that physiology has
Awake user goes examination in hospital to treat in time, full-scope safeguards women's health, lifts quality of life.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Fig. 2 is workflow diagram of the invention.
Fig. 3 is the structural representation of blood examination chip in the present invention.
Fig. 4 is the longitudinal sectional view of blood examination chip in the present invention.
Fig. 5 is the structural representation in the present invention during blood examination detecting pathogen.
In figure：
1- tapon bodies；
11- absorbers；12- extracts rope out；13- guiding gutters；
2- intellectual monitoring modules；
21- blood examination chips；211- carrier substrates；212- conductive substrates；213- insulation glue-lines；214- probe through holes；215- nanometers
Metal probe；2151- metal probe bodies；21511- metal cartridges；21512- metallic substrates；2152- thorn-likes are raised；2153-
Antibody molecule；216- pathogen molecules；
22- sensors；23- physical therapy chips；24- data acquisition modules；25- wireless communication modules；
3- power modules；
4- intelligent terminals；
5- cloud servers.
Embodiment
With reference to the accompanying drawings and detailed description, the present invention and its advantageous effects are described in detail, still,
The embodiment of the present invention is not limited to this.
As shown in Fig. 1 ~ 5, a kind of Intelligent sanitary sliver, including tapon body 1 is provided with tapon body 1
Intellectual monitoring module 2 and the power module 3 being electrically connected with intellectual monitoring module 2.
Tapon body 1 includes absorber 11, and the surface of absorber 11 is provided with guiding gutter 13, and one end of absorber 11 is set
There is at least one to extract rope 12 out.Wherein, absorber 11 is in the form of a column, and it is typically formed using cotton or staple fibre compacting, water conservancy diversion
The setting of groove 13 contributes to length direction distribution of the menses along absorber 11, and extraction rope 12 is easy to the absorber 11 by menses are filled
Taken out from intravaginal.It should be noted that conduit formation catheter type tapon can also be set outside tapon body 1, this
Tapon can be inserted intravaginal by sample by conduit, more convenient, relatively sanitary compared to being inserted with finger.
Intellectual monitoring module 2 includes that the blood examination chip 21 of menses can be detected, can monitor the biography of tapon internal environment
Sensor 22, the data acquisition module 24 being electrically connected with respectively with blood examination chip 21 and sensor 22 and by gathered data to intelligence
Can terminal 4 transmit wireless communication module 25, intelligent terminal 4 is connected with cloud server 5, will can so gather every time with
The data Cun Chudao cloud servers 5 of analysis, are to customize personalized tapon and disease in the future so as to set up individual database
Diagnosis provides important references.
Wherein, intelligent terminal 4 is at least one of mobile phone, computer and wearable device；Wireless communication module 25 is indigo plant
At least one of tooth, RFID, Z-wave, HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi；Sensor 22 is temperature
At least one of sensor, humidity sensor, flow sensor, pressure sensor and heat-sensitive sensor, its main function is
Analysis and detection to privates environment and to menstrual blood physiological data.
It is preferred that, intellectual monitoring module 2 of the invention is placed in absorber 11 by way of placing or being implanted into；So may be used
To be filtered out the blood clot that menstrual blood contains by the top layer of absorber 11, purified equivalent to menstrual blood, prevent influence
The testing result of blood examination chip 21.
Wherein, blood examination chip 21 includes carrier substrate 211, is arranged at the conductive substrate 212 of carrier substrate 211 and covers
The insulation glue-line 213 of conductive substrate 212 is placed on, insulation glue-line 213 offers probe through hole 214, and probe through hole 214 is provided with prominent
For the nano metal probe 215 on insulation glue-line 213 surface, nano metal probe 215 include metal probe body 2151 and
The thorn-like projection 2152 on the surface of metal probe body 2151 is distributed in, thorn-like projection 2152 and its surrounding are attached with detection pathogen
Antibody molecule 2153, antibody molecule 2153 is at least one of DNA molecular, RNA molecule and immobilised enzymes molecule.
The blood examination chip 21 of the present invention can carry out real-time menses inspection, can be given within several minutes even several seconds
Go out menses testing result.So as to allow user to know the health status of oneself in time, to carry out timely prevention from suffering from the diseases
Or treatment, while eliminating the trouble that hospital is taken a blood sample, this highly shortened the interval between detection and treatment
Time so that user can quickly, obtain diagnostic data at low cost, and the blood examination conventional compared to hospital, the blood examination
Chip 21 causes detection more convenient, more efficient.
In addition, the internal environment of tapon can be monitored by temperature and moisture sensors, and carried by intelligent terminal 4
The user that wakes up changes tapon in the suitable time；Moreover, it is also possible to be passed through by setting the sensor 22 of difference in functionality to recognize
The physiological datas such as the color of blood, pH value, and bacterial concentration, and the data of collection are sent to intelligence by wireless communication module 25
Terminal 4, the physiological status of user is relatively can be inferred that by carrying out data analysis, if it find that physiology will when having an exception
User is reminded to go examination in hospital to treat in time, full-scope safeguards women's health.
The Cleaning Principle of blood examination chip 21 is in the present invention：Being attracted by antibody molecule 2153 and captured may be through blood sample
Pathogen molecule 216 present in this, and nano metal probe 215 is then equivalent to microsensor, when being attached to the anti-of its surface
Body molecule 2153 is when pathogen molecule 216 is combined, and nano metal probe 215 can produce electric current, according to the electric current of generation
Power determines the type of pathogen molecule 216.
Because all DNA fragmentations have excellent characteristics, optionally can closely it be tied with another segment DNA fragment
Close.For example, the antibody molecule 2153 by designing and synthesizing high degree of specificity, nano metal is attached to by the antibody molecule 2153
On probe 215, the DNA molecular of staphylococcus aureus present in menses is caught with this, when the antibody molecule 2153 with it is golden yellow
When the staphylococcic DNA molecular of color is combined, nano metal probe 215 will produce electric current.
In addition, immobilised enzymes molecule can also be adhered in the present invention to detect the component target in menses, such as in nanometer
Adhere to the glucose oxidase of solidification on metal probe 215, for measuring the concentration of glucose in blood；In nano metal probe
Adhere to the LO of solidification on 215, for measuring the concentration of lactic acid in blood；Adhere on nano metal probe 215 solid
The cholesterol oxidase and cholesterol ester hydrolase of change, for measuring the concentration of Blood Cholesterol；In nano metal probe 215
The b- HBDs and reducibility coenzyme of upper attachment solidification, for measuring the concentration of ketoboidies in blood.Its principle is, these
With the material such as the blood glucose in blood, cholesterol, lactic acid, ketoboidies redox reaction occurs for immobilised enzymes molecule respectively, produces oxygen
Galvanic current, therefore the dense of the materials such as Blood Glucose, cholesterol, lactic acid and ketoboidies can be determined by the size for measuring electric current
Degree.
It should be noted that the present invention can set multiple knots of nano metal probe 215 on the surface of carrier substrate 211
Structure, adsorbs different types of antibody molecule 2153 on each nano metal probe 215.So, on blood examination chip 21
As soon as only needing sample of bleeding, multiple pathogens can be analyzed, and most methods are once only capable of detecting a kind of pathogen molecule 216.
Inventor has found that a drop is used through the quantity levels of pathogen molecule 216 in blood sample and doctor in research process
The blood sample that syringe needle takes out is suitable.In this case, a pathogen molecule 216 of the drop through blood sample is typically less than 1000
It is individual, or even less.Even if having adjusted the quantity of pathogen molecule 216, its quantity in through blood sample is set to reach million ranks,
The current signal detected is also fainter.Pass through the peptizaiton of thorn-like projection 2152 so that have around antibody molecule 2153
Bigger space, the liquid that carry pathogen molecule 216 flows through these spaces and is also easier to, so, the He of antibody molecule 2153
Pathogen molecule 216 also just has much more chance to be in contact with each other, so as to effectively improve sensitivity and the accuracy of detection.
As the preferred scheme of the present invention, thorn-like is raised and its surrounding is also attached with metallic molecule ruthenium.Wherein, metallic molecule
Ruthenium because positive charge of the ruthenium with unit, therefore can be adsorbed with negative electrical charge equivalent to the effect of amplifier
On pathogen molecule 216；So, the complex of ruthenium and pathogen molecule 216 is easy to seize electricity from nano metal probe 215
Son, so as to produce one electric current for being enough to detect.
As the preferred scheme of the present invention, metal probe body 2151 includes the metal column being arranged in probe through hole 214
Body 21511, and the hemispherical metallic substrates 21512 on insulation glue-line 213 surface are protruded from, thorn-like projection 2152 is distributed in hemisphere
The surface of shape metallic substrates 21512.Compared to square structure, the surface of metal probe body 2151 is designed to hemispherical junction
Structure, can so be effectively increased the surface area of metal probe, so that " growth " of follow-up thorn-like projection 2152 is more beneficial for, and
The attachment of antibody molecule 2153 and scattered.
As the preferred scheme of the present invention, the height of thorn-like projection 2152 is 1 ~ 100nm.If the height of thorn-like projection 2152
It is too small, then it can not play a part of effectively disperseing antibody molecule 2153；If the height of thorn-like projection 2152 is excessive, disperse antibody point
Sub 2153 effects do not increase anti-drop, so can not only increase manufacturing cost, while can increase the volume of whole blood examination chip 21 yet.
As the preferred scheme of the present invention, the preparation method of blood examination chip 21 comprises the following steps：
Step 1: carrying out surface cleaning processing to carrier substrate 211, conductive substrate 212 and photoresist layer are then coated successively, is connect
And be exposed and develop under the irradiation of ultraviolet light, and unexposed conductive substrate 212 is removed using metal etchants, with shape
Into required circuitous pattern；Wherein, conductive substrate 212 is conductive metal layer, preferably layer gold or layers of copper, and photoresist layer is preferred
SU-8 photoresists；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line 213 that insulate is then coated with, and to insulation glue-line
213 carry out getting through hole processing, obtain the chip substrate of through hole containing probe 214；Wherein, insulation glue-line 213 is novolac resin layer, ring
Oxygen tree lipid layer, polyimide resin layer, polyester resin layer, polyphenylene oxide resin layer, cyanate resin lipid layer or polyflon
Layer；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, probe through hole 214 is carried out
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
The nano metal probe 215 of projection 2152；
Step 5: thorn-like projection 2152 and its around load detecting pathogen antibody molecule 2153, be then packaged place
Reason, that is, the blood examination chip 21 obtained.
Wherein, carrier substrate 211 is silicon chip, graphene substrate or silicon carbide substrate, and it is excellent chip carrier,
Important foundation is provided for high-precision blood examination chip 21；Insulation glue-line 213 then plays insulation passivation, in order to nano metal
The making of probe 215；The conduction and detection connection of conductive substrate 212 then for electric current.
It should be noted that in the manufacturing process of blood examination chip 21, the time of plating is crucial, if the time mistake of plating
It is long, it can not just obtain the metal probe structure of the projection of thorn-like containing nanometer 2152；But the time of plating is too short, and metal probe structure is firm
Just stop " growing " to nanoscale, can not equally obtain required nano metal probe 215.In addition, to electroplating voltage/electric current
Control is also of crucial importance, and otherwise, electroplating voltage/electric current is too high or too low can not also to obtain required nano metal probe 215.
As the preferred scheme of the present invention, metal salt solution is by HAuCl in step 34With HCl by volume 1：（1~10）
Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration is 10 ~ 500mmol/L.Gold is the good of electric current
Conductor, therefore, selection Nano-Au probe can effectively improve sensitivity and the accuracy of detection.
As the preferred scheme of the present invention, intellectual monitoring module 2 also includes physical therapy chip 23, and physical therapy chip 23 is magnetic therapy core
At least one of piece, negative ion chip, Nano Silver chip, far infrared chip and activated carbon chip.By set it is a kind of or
Several different physical therapy chips 23, such as can set the magnetic therapy chip with healthcare function, the magnetostatic field of this magnetic material,
Biological magnetic is produced when with human contact, magnetic energy is supplemented, body local microcirculation can be promoted, biology enzyme is improved and increases, increase
The acidic materials of vaginal fluid, the magnetic therapy chip is typically made up of neodymium-iron-boron magnetic material, and carries out appropriate magnetize.This
Outside, the chip with anti-inflammatory or sterilizing function of anion, far infrared, Nano Silver, activated carbon etc can also be set.Its
In, multiple chips can be that function is consistent or combination of difference in functionality, main the tight of alleviation female menstrual period that can calm
Mood is opened, evades menstruation infection, goes to eliminate the unusual smell, and with bactericidal antiphlogistic effect, is relaxed to build one to female pathology period
Suitable, pleasure mental state.Therefore, physical therapy chip 23 of the present invention can effectively alleviate the lower abdominal pain of menstrual period appearance, falling inflation；And
Compared to drug therapy, the setting of physical therapy chip 23 can promote female body local microcirculation system, improve biology enzyme and increase,
Increase and the acidic materials for maintaining vaginal fluid, maintain the balance of microcirculqtory system so that design of the invention is more cared about
The health of women.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in above-mentioned embodiment, every those skilled in the art exist
Made any conspicuously improved, replacement or modification belong to protection scope of the present invention on the basis of the present invention.This
Outside, although having used some specific terms in this specification, these terms merely for convenience of description, not to the present invention
Constitute any limitation.
Claims (10)
1. be provided with a kind of Intelligent sanitary sliver, including tapon body, the tapon body intellectual monitoring module,
And the power module being electrically connected with intellectual monitoring module, the intellectual monitoring module is including that can detect the blood examination core of menses
Piece, the sensor that tapon internal environment can be monitored, the number being electrically connected with respectively with the blood examination chip and the sensor
The wireless communication module transmitted according to acquisition module and by gathered data to intelligent terminal；The blood examination chip includes carrier base
Piece, the conductive substrate for being arranged at the carrier substrate and the insulation glue-line for being covered in the conductive substrate, the insulation glue-line
Probe through hole is offered, the probe through hole is provided with the nano metal probe for protruding from insulation film surface, the nanogold
Category probe includes metal probe body and is distributed in the thorn-like projection of metal probe body surface, and the thorn-like is raised and its all
Enclose the antibody molecule for being attached with detection pathogen.
2. Intelligent sanitary sliver according to claim 1, it is characterised in that：The antibody molecule is DNA molecular, RNA divides
At least one of son and immobilised enzymes molecule.
3. Intelligent sanitary sliver according to claim 1, it is characterised in that：The metal probe body includes being arranged at spy
Metal cartridge in pin through hole, and the hemispherical metallic substrates of insulation film surface are protruded from, the thorn-like projection is distributed in
The surface of the hemispherical metallic substrates.
4. Intelligent sanitary sliver according to claim 1, it is characterised in that：The raised height of the thorn-like is 1 ~ 100nm.
5. Intelligent sanitary sliver according to claim 1, it is characterised in that the preparation method of the blood examination chip include with
Lower step：
Step 1: carrying out surface cleaning processing to carrier substrate, conductive substrate and photoresist layer are then coated successively, then in purple
It is exposed and develops under the irradiation of outer light, and unexposed conductive substrate is removed using metal etchants, with needed for is formed
Circuitous pattern；
Step 2: stripping photolithography glue-line, and washing and drying treatment is carried out, the glue-line that insulate is then coated with, and insulation glue-line is entered
Row gets through hole processing, obtains the chip substrate of the through hole containing probe；
Step 3: chip substrate is put into the electroplating bath containing metal salt solution, switch on power, electricity is carried out to probe through hole
Plating, the voltage for control plating is 5 μ V ~ 500mV, and the electric current of plating is 0.01 μ A ~ 100mA, plating duration for 1 ~
30min；
Step 4: after the completion of to be electroplated, 1 ~ 10h of vacuum drying is carried out at a temperature of 25 ~ 85 DEG C, obtaining surface distributed has thorn-like
Raised nano metal probe；
Step 5: thorn-like it is raised and its around load detecting pathogen antibody molecule, be then packaged processing, that is, obtain
Described blood examination chip.
6. Intelligent sanitary sliver according to claim 5, it is characterised in that：Metal salt solution described in step 3 by
HAuCl4With HCl by volume 1：（1~10）Mix, wherein HAuCl4Concentration be 5 ~ 100mmol/L, HCl concentration is
10~500mmol/L。
7. Intelligent sanitary sliver according to claim 1, it is characterised in that：The tapon body includes absorber,
The surface of the absorber is provided with guiding gutter, and one end of the absorber extracts rope out provided with least one.
8. Intelligent sanitary sliver according to claim 1, it is characterised in that：The sensor is temperature sensor, humidity
At least one of sensor, flow sensor, pressure sensor and heat-sensitive sensor；The wireless communication module be bluetooth,
At least one of RFID, Z-wave, HomeRF, ZigBee, UWB, NFC, IrDA and Wi-Fi.
9. Intelligent sanitary sliver according to claim 1, it is characterised in that：The intellectual monitoring module also includes physiotherapy core
Piece, the physical therapy chip is in magnetic therapy chip, negative ion chip, Nano Silver chip, far infrared chip and activated carbon chip
It is at least one.
10. Intelligent sanitary sliver according to claim 1, it is characterised in that：The intelligent terminal connects with cloud server
Connect, the intelligent terminal is at least one of mobile phone, computer and wearable device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336782.XA CN107149524A (en) | 2017-05-14 | 2017-05-14 | Intelligent sanitary sliver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336782.XA CN107149524A (en) | 2017-05-14 | 2017-05-14 | Intelligent sanitary sliver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107149524A true CN107149524A (en) | 2017-09-12 |
Family
ID=59793611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710336782.XA Pending CN107149524A (en) | 2017-05-14 | 2017-05-14 | Intelligent sanitary sliver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107149524A (en) |
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| CN108492881A (en) * | 2018-04-12 | 2018-09-04 | 福建省冬青日化工贸有限公司 | A kind of detection female menstrual period health status control system, information data processing terminal |
| CN110353886A (en) * | 2018-04-11 | 2019-10-22 | 常州英莱克斯生物工程有限公司 | A kind of novel intelligent health sliver |
| CN111494098A (en) * | 2020-05-25 | 2020-08-07 | 华中科技大学同济医学院附属协和医院 | Intelligent detection method for sanitary towel and menstrual period health condition |
| CN115087416A (en) * | 2019-11-08 | 2022-09-20 | 健康小环境有限公司 | System of panty liner and sanitary napkin |
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Application publication date: 20170912 |