CN107137827B - 3D individualized printing manufacturing method of accurate tumor radiotherapy positioning product and product thereof - Google Patents

3D individualized printing manufacturing method of accurate tumor radiotherapy positioning product and product thereof Download PDF

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CN107137827B
CN107137827B CN201710309750.0A CN201710309750A CN107137827B CN 107137827 B CN107137827 B CN 107137827B CN 201710309750 A CN201710309750 A CN 201710309750A CN 107137827 B CN107137827 B CN 107137827B
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positioning product
dimensional image
patient
product
tumor
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CN107137827A (en
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汪大清
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Suzhou Puneng Medical Technology Co.,Ltd.
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Guangdong Plannet Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1052—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using positron emission tomography [PET] single photon emission computer tomography [SPECT] imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1054—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using a portal imaging system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1096—Elements inserted into the radiation path placed on the patient, e.g. bags, bolus, compensators

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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The invention discloses a 3D individualized printing manufacturing method of a tumor precise radiotherapy positioning product and a product thereof, wherein the method comprises the following steps: scanning the tumor part of the patient to obtain the tumor part of the patient and the surface contour of the body surface of the patient, and completing the construction of a three-dimensional image of a first part of a positioning product according to the surface contour corresponding to the tumor part of the patient; scanning a bed plate of the treatment equipment to obtain three-dimensional image data of the bed plate of the treatment equipment; completing the construction of a three-dimensional image of a second part of a positioning product according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the treatment equipment; fusing the three-dimensional image of the first part of the positioning product with the three-dimensional image of the second part of the positioning product, thereby completing the construction of the three-dimensional image of the positioning product; and transmitting the three-dimensional image of the constructed positioning product to a 3D printing terminal, namely finishing the printing of the positioning product. The problem of fixing the error that introduces of fixing device multicomponent among the prior art is solved.

Description

3D individualized printing manufacturing method of accurate tumor radiotherapy positioning product and product thereof
Technical Field
The invention relates to the technical field of tumor radiotherapy, in particular to a 3D individualized printing manufacturing method of a tumor precise radiotherapy positioning product and a product thereof.
Background
At present, the posture fixing solution for radiotherapy of tumor patients is a radiotherapy positioning film and/or a vacuum pad, and a carbon fiber fixing supporting plate and a headrest are used as auxiliary materials. The radiotherapy positioning film/vacuum pad, the headrest, the carbon fiber fixing plate and the like form a set of body position fixing device. After the patient confirms that the patient is a tumor patient and decides to perform radiotherapy, the patient goes to a membrane chamber to make a membrane/a vacuum pad, and then goes to a CT positioning chamber, a position fixing device (a thermoplastic membrane/a vacuum pad) is worn to perform tumor CT positioning, a CT image of the tumor part of the patient is obtained, and the CT image is transmitted to a TPS to perform radiotherapy plan design. After confirming the feasibility of the radiotherapy technology and plan verification, the patient wears the body position fixing device again to the accelerator room for fractionated treatment.
The prior art has the following defects:
(1) in the fractionated treatment process, because the materials of products such as radiotherapy positioning films, vacuum pads, foam pillows and the like are all non-hard materials, as long as the body of a patient slightly moves or the gravity distribution changes, the body position fixing device can deform, the slight movement of the patient cannot be effectively limited, and the body surface contour of the patient most suitable for radiotherapy cannot be reflected, so that inevitable errors are generated.
(2) In addition, the radiotherapy locating film of hot compress type and the locating pad of evacuation type of moulding are all made by more crude material and are formed, can't shape patient's health well, can't embody patient's body surface profile details, and the positioning accuracy who provides does not reach the required precision of accurate radiotherapy completely.
(3) Factors such as fixation between a radiotherapy positioning film/vacuum pad and a carbon fiber fixing base, fixation between the whole body position fixing device and a treatment equipment bed plate, positioning guidance of a technician, understanding of the guidance by a patient and the like all introduce errors, so that the problems of low treatment precision of tumors, low local control rate of the tumors and the like are caused.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a 3D individualized printing manufacturing method of a precise tumor radiotherapy positioning product and a product thereof, and solves the problem of error introduced by multi-component fixing of a fixing device in the prior art.
The purpose of the invention is realized by adopting the following technical scheme:
A3D individualized printing manufacturing method of a tumor precise radiotherapy positioning product comprises the following steps:
scanning the tumor part of the patient to obtain the tumor part of the patient and the surface contour of the body surface of the patient, and completing the construction of a three-dimensional image of a first part of a positioning product according to the surface contour corresponding to the tumor part of the patient;
scanning a bed plate of the treatment equipment to obtain three-dimensional image data of the bed plate of the treatment equipment;
completing the construction of a three-dimensional image of a second part of a positioning product according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the treatment equipment;
fusing the three-dimensional image of the first part of the positioning product with the three-dimensional image of the second part of the positioning product, thereby completing the construction of the three-dimensional image of the positioning product;
and transmitting the three-dimensional image of the constructed positioning product to a 3D printing terminal, namely finishing the printing of the positioning product.
Further, the scanning of the tumor region of the patient to obtain the tumor region of the patient and the surface contour of the body surface of the patient, and completing the construction of the three-dimensional image of the first part of the positioning product according to the surface contour corresponding to the tumor region of the patient specifically comprises:
the tumor part of the patient is scanned by using an acousto-optic medical imaging technology to obtain a 3D medical image of the tumor part and surrounding anatomical structures of the patient, and the 3D medical image is transmitted to a reconstruction system of a 3D printing terminal.
Further, the thickness of the three-dimensional image of the first part of the positioning product constructed as described above was 2mm, and the mesh ratio of the first part of the positioning product was 36%.
Further, the construction of the three-dimensional image of the first part of the positioning product is completed according to the surface contour corresponding to the tumor part of the patient, and the method also comprises the step of smoothing the contact surface of the body surface of the patient and the three-dimensional image of the first part of the positioning product, wherein the processing precision is 1 mu m.
Further, the step of constructing a three-dimensional image of a second part of the positioning product according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the treatment device includes: the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are fused together, a gap between the patient and the bed plate of the treatment equipment is observed, and then the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are separated according to the ray penetration rate of the bed plate of the treatment equipment and the clinical irradiation requirement of the tumor, so that the construction of the three-dimensional image of the second part of the positioning product is completed.
Further, the method also comprises the step of smoothing the contact surface of the back contour of the patient and the second part of the positioning product, wherein the precision of the smoothing is 1 μm.
Further, the three-dimensional image of the constructed positioning product is transmitted to a 3D printing terminal, namely, the printing of the positioning product is completed, and the printing material is high molecular cellulose.
Furthermore, the thickness of the first part of the printed positioning product is 2mm, the mesh rate of the first part of the positioning product is 36%, the thickness of the second part of the printed positioning product is 1cm, and air bubbles are injected into the second part of the positioning product, so that the hollow part of the second part of the positioning product accounts for 65%.
The purpose of the invention is also realized by adopting the following technical scheme:
a product for positioning tumor precise radiotherapy comprises a first positioning product part and a second positioning product part, wherein the first positioning product part and the second positioning product part are printed by adopting the printing and manufacturing method in the technical scheme.
Further, the first product part and the second product part are connected by a shaft.
Compared with the prior art, the invention has the beneficial effects that:
according to the technical scheme, the accurate radiotherapy positioning product for the tumor, which is produced by adopting a 3D printing technology, is an integrated positioning device, and can realize body position fixation only by being fixed with a bed plate of treatment equipment, so that the positioning error of fixation among all parts is reduced, the body position fixation precision is improved to a great extent, and accurate radiotherapy is truly realized in tumor radiotherapy. In addition, the three-dimensional image of the positioning product is reconstructed, printed and manufactured according to the body surface contour of each patient, so that ideal fitting degree is provided, the body position fixing precision is improved, and accurate radiotherapy of tumors is realized.
The concrete effects are as follows:
(1) the tumor treatment precision is improved, the error is reduced, the radiation dose of normal tissues is reduced, the treatment effect is improved, and the survival quality of patients is improved;
(2) the position fixing product is customized individually, a comfortable fixed position is provided, and the treatment experience of a patient is improved;
(3) the 3D image of the patient can be acquired by using medical image data when the patient is diagnosed or a noninvasive high-resolution scanning technology to customize a positioning product, so that the time of waiting for treatment of the patient is shortened, and the irradiation is reduced;
(4) the current processes of molding, positioning and resetting are optimized, the positioning time of a technician is saved, and the human error is reduced;
(5) the current additional equipment such as a fixed supporting plate, a headrest and the like is eliminated, and the positioning product is fixed on the treatment bed, so that the error in the link is reduced, and the operation cost of a hospital is reduced;
(6) the fixed product that 3D printed adopts degradable environmental protection polymer biomaterial, reduces medical rubbish. The problem of traditional vacuum bag adopt ordinary foam particle, not environmental protection, and evacuation shaping positioning method, leak gas easily in the treatment process, can't provide former location position, cause treatment error, medical safety accident scheduling easily appears is solved.
Drawings
FIG. 1 is a flow chart of a 3D individualized printing manufacturing method of a tumor precise radiotherapy positioning product according to the invention;
fig. 2 is a schematic structural diagram of the tumor precise radiotherapy positioning product of the invention.
In the figure: 1. positioning a first portion of a product; 2. positioning a second portion of the product; 3. positioning pins; 4. fixing pins for fixing the product and the bed board of the therapeutic equipment.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that any combination of the embodiments or technical features described below can be used to form a new embodiment without conflict.
The invention produces the positioning product for accurate tumor radiotherapy based on the 3D printing technology, and integrally produces the product.
As shown in fig. 1, a 3D personalized printing manufacturing method of a tumor precise radiotherapy positioning product comprises:
scanning the tumor part of the patient to obtain the tumor part of the patient and the surface contour of the body surface of the patient, and completing the three-dimensional image construction of a first part 1 of a positioning product according to the surface contour corresponding to the tumor part of the patient;
the tumor patient positioning image based on the noninvasive high-resolution acousto-optic medical imaging technology is used for reconstructing a 3D image of a positioning product: the introduced noninvasive high-resolution acousto-optic medical imaging technology is used for scanning the tumor part of the patient to obtain a high-resolution 3D medical image of the tumor part and surrounding anatomical structures of the patient, and the image is transmitted to a 3D printing terminal reconstruction system by adopting a fidelity digital transmission technology. The reconstruction system may be Auto CAD or the like software. By utilizing the reconstruction system, a first part (upper part) three-dimensional image of the tumor patient body position fixing product is reconstructed in a personalized manner according to the surface contour on the body surface of the patient image.
Scanning a bed plate of the treatment equipment to obtain three-dimensional image data of the bed plate of the treatment equipment;
three-dimensional images of therapeutic equipment bed plates based on non-invasive high-resolution medical imaging technology: the imaging technology is utilized to scan the bed plate of the treatment equipment to obtain the three-dimensional image data of the bed plate, and the three-dimensional image data is transmitted to the image reconstruction system by adopting the fidelity digital transmission technology.
Completing the construction of a 2-dimensional image of a second part of a positioning product according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the treatment equipment;
fusing the three-dimensional image of the first part 1 of the positioning product with the three-dimensional image of the second part 2 of the positioning product, thereby completing the construction of the three-dimensional image of the positioning product;
and after the three-dimensional image of the body position positioning product is obtained, comparing the three-dimensional image with the bed plate three-dimensional image of the treatment equipment, and reconstructing the three-dimensional image of the fixing scheme between the positioning product and the treatment bed plate.
And transmitting the three-dimensional image of the constructed positioning product to a 3D printing terminal, namely finishing the printing of the positioning product.
Converting the reconstructed three-dimensional image data of the whole device into an STL file which can be identified by a 3D printer (3D printing terminal), and transmitting the STL file to the 3D printer by adopting a fidelity digital transmission technology; this process must ensure the fidelity of the data transmission so that the accuracy of the positioning device can be guaranteed.
Printing of the product:
(1) selecting high molecular cellulose which meets clinical requirements through ray penetration rate and human body anaphylaxis tests as a printing material.
(2) When a 3D printer is used for printing, the internal printing precision of the upper part of the product is 0.5mm, and the printing precision of the surface contacting with the human body is controlled to be 1 mu m; the lower half part of the product is printed with 0.5mm of printing precision, and the part of the product in contact with the skin on the back of a human body is printed with 1 micron of printing precision;
(3) and after printing is finished, smoothing the surface of the product to enable the product to have the optimal fit with the surface of a human body.
Wherein, scan patient's tumour position, obtain patient's tumour position and the surface profile of patient's body surface to accomplish the 1 three-dimensional image of location product first part according to the corresponding surface profile in patient's tumour position and construct, specifically do:
the tumor part of the patient is scanned by using an acousto-optic medical imaging technology to obtain a 3D medical image of the tumor part and surrounding anatomical structures of the patient, and the 3D medical image is transmitted to a reconstruction system of a 3D printing terminal.
The thickness of the three-dimensional image of the first portion 1 of the positioning product was constructed to be 2mm, and the mesh rate of the first portion 1 of the positioning product was 36%.
And finishing the three-dimensional image construction of the first part 1 of the positioning product according to the surface contour corresponding to the tumor part of the patient, and smoothing the contact surface of the body surface of the patient and the three-dimensional image of the first part 1 of the positioning product with the processing precision of 1 micrometer.
The construction of a three-dimensional image of a second part of a positioning product is completed according to a contour image of the back of the patient and a three-dimensional image of a bed plate of the treatment equipment, and the construction method specifically comprises the following steps: the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are fused together, a gap between the patient and the bed plate of the treatment equipment is observed, and then the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are separated according to the ray penetration rate of the bed plate of the treatment equipment and the clinical irradiation requirement of the tumor, so that the construction of the 2-dimensional image of the second part of the positioning product is completed.
The three-dimensional image of the back of the patient and the three-dimensional image of the treatment equipment are fused together, a gap between a human body and a bed plate is observed, the two images are separated according to the condition that the ray penetration rate of the bed plate is 99.8 percent and the clinical irradiation requirement of a tumor (the requirement depends on the tumor type and the irradiation requirement of each patient is different), and the reconstruction of the three-dimensional image of the second part (lower part) of the positioning device is carried out according to the back contour of the three-dimensional image of the human body and the contour of the treatment equipment.
And smoothing the contact surface of the product and the back of the human body, namely smoothing the contact surface of the contour of the back of the patient and the second part 2 of the positioning product, wherein the precision of the smoothing is 1 mu m. The thickness of the reconstructed product is 1cm, air bubbles are injected into the part of the product, the proportion of the hollow part is 65%, but the mechanical structure of the hollow part is not changed, so that the material cost and the production time cost are saved.
And transmitting the three-dimensional image of the constructed positioning product to a 3D printing terminal, namely finishing the printing of the positioning product, wherein the printing material is high molecular cellulose.
The thickness of the first part 1 of the printed positioning product is 2mm, the mesh rate of the first part 1 of the positioning product is 36%, the thickness of the second part 2 of the printed positioning product is 1cm, and air bubbles are injected into the second part 2 of the positioning product, so that the proportion of the hollow part of the second part 2 of the positioning product reaches 65%.
The purpose of the invention is also realized by adopting the following technical scheme:
as shown in fig. 2, an accurate radiotherapy positioning product for tumor comprises a first positioning product part 1 and a second positioning product part 2, wherein the first positioning product part 1 and the second positioning product part are printed by the printing and manufacturing method in the above technical scheme.
The left side of the product is hollowed out and fused according to the lying direction of the patient (namely the view direction in fig. 2), and the mesh rate reaches 36%, so that when the patient lies in the positioning device, a treatment technician turns over the product flexibly and is not easy to break; and also provides a more comfortable therapeutic experience for the patient. On the other side, the edge of the upper part of the product is subjected to edge banding treatment; the lower part is also processed by edge banding and integrated with the rotary fixing positioning pin 3. When a patient is in a position, the upper part of the positioning device can be fixed only by rotating the fixing positioning pin 3, and after treatment is finished, the fixing of the device can be cancelled by rotating the positioning pin 3, so that the patient can come out of the fixing device;
the first product part and the second product part are connected by a shaft.
The specific process is as follows: 1. scanning a patient and an accelerator treatment couch by adopting a non-invasive high-resolution imaging technology to obtain three-dimensional images of the patient and the accelerator treatment couch, and transmitting the images to an image reconstruction system of a 3D printer through a data fidelity transmission system for image modification;
2. reconstructing a three-dimensional image (semi-finished product, three-dimensional image without fixed solution) of a tumor precise radiotherapy positioning product according to the three-dimensional image of the patient;
3. reconstructing a three-dimensional image of a fixing solution of a positioning product according to three-dimensional images (semi-finished product images) of an accelerator treatment bed and a tumor precise radiotherapy positioning product, and fusing the three-dimensional image of the product and the three-dimensional image of the fixing solution together to obtain a complete three-dimensional image of the novel tumor precise radiotherapy positioning product;
4. the three-dimensional image of the product is transmitted to a 3D printing terminal, and the material qualified by clinical tests is used for printing to obtain a novel accurate radiotherapy positioning product for tumors.
The using process of the invention is as follows:
1. after the novel accurate tumor radiotherapy positioning product is obtained, the hospital tumor radiotherapy center checks and accepts the product, and the patient carries the product to reset after the product passes the acceptance;
2. after the resetting is passed, the patient carries the product to carry out the body position setting in the tumor radiotherapy room: the patient lies on the product, the upper part and the lower part are folded and fastened, the lower part of the product is directly fixed with the accelerator treatment bed through 4 positioning products and the treatment equipment bed plate fixing pins 4, and after the product is fixed, radiotherapy can be directly carried out.
Compared with the prior art, the technical scheme has the following advantages:
(1) the current complex patient positioning process is optimized, and auxiliary equipment such as a carbon fiber fixing support plate, a radiotherapy headrest and the like of the current fixing solution is eliminated;
(2) the PET-CT is combined with the positioning image to make a treatment plan, so that the repeatability of the body position is improved, the fusion error is reduced, and the delineation precision of a target area is improved;
(3) the time for the patient to wait for the treatment plan is shortened, and the radiotherapy timeliness is improved.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims (10)

1. A3D individuation printing manufacturing method of accurate radiotherapy location product of tumour, its characterized in that: the method comprises the following steps:
scanning the tumor part of the patient to obtain the tumor part of the patient and the surface contour of the body surface of the patient, and completing the construction of a three-dimensional image of a first part of a positioning product according to the surface contour corresponding to the tumor part of the patient;
scanning a bed plate of the treatment equipment to obtain three-dimensional image data of the bed plate of the treatment equipment;
completing the construction of a three-dimensional image of a second part of a positioning product according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the treatment equipment;
fusing the three-dimensional image of the first part of the positioning product with the three-dimensional image of the second part of the positioning product, thereby completing the construction of the three-dimensional image of the positioning product;
and transmitting the three-dimensional image of the constructed positioning product to a 3D printing terminal, namely finishing the printing of the positioning product.
2. The 3D personalized printing and manufacturing method of the precise radiotherapy positioning product for tumor as claimed in claim 1, wherein the tumor part of the patient is scanned to obtain the tumor part of the patient and the surface contour of the body surface of the patient, and the construction of the three-dimensional image of the first part of the positioning product is completed according to the surface contour corresponding to the tumor part of the patient, specifically:
the tumor part of the patient is scanned by using an acousto-optic medical imaging technology to obtain a 3D medical image of the tumor part and surrounding anatomical structures of the patient, and the 3D medical image is transmitted to a reconstruction system of a 3D printing terminal.
3. The 3D personalized printing and manufacturing method of tumor precise radiotherapy positioning product as claimed in claim 1, wherein the thickness of the three-dimensional image of the first part of the constructed positioning product is 2mm, and the mesh rate of the first part of the positioning product is 36%.
4. The 3D personalized printing and manufacturing method of the tumor precise radiotherapy positioning product according to any one of claims 1 to 3, wherein the construction of the three-dimensional image of the first part of the positioning product is completed according to the surface contour corresponding to the tumor part of the patient, and the method further comprises the step of smoothing the contact surface between the body surface of the patient and the three-dimensional image of the first part of the positioning product, wherein the processing precision is 1 μm.
5. The 3D personalized printing and manufacturing method of tumor precise radiotherapy positioning product as claimed in claim 1, wherein the construction of the three-dimensional image of the second part of the positioning product is completed according to the contour image of the back of the patient and the three-dimensional image of the bed plate of the therapy apparatus, which comprises: the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are fused together, a gap between the patient and the bed plate of the treatment equipment is observed, and then the three-dimensional image of the back contour of the patient and the three-dimensional image of the bed plate of the treatment equipment are separated according to the ray penetration rate of the bed plate of the treatment equipment and the clinical irradiation requirement of the tumor, so that the construction of the three-dimensional image of the second part of the positioning product is completed.
6. The 3D personalized printing and manufacturing method of tumor precise radiotherapy positioning products according to claim 5, further comprising smoothing the contact surface of the back contour of the patient and the second part of the positioning products, wherein the precision of the smoothing process is 1 μm.
7. The 3D individualized printing and manufacturing method of the precise tumor radiotherapy positioning product according to claim 1, wherein the constructed three-dimensional image of the positioning product is transmitted to a 3D printing terminal, so that the positioning product is printed, and the printing material is high molecular cellulose.
8. The 3D individualized printing and manufacturing method of the precise radiotherapy positioning product for tumor as claimed in claim 7, wherein the thickness of the first part of the printed positioning product is 2mm, the mesh rate of the first part of the positioning product is 36%, the thickness of the second part of the printed positioning product is 1cm, and air bubbles are injected into the second part of the positioning product, so that the hollow part of the second part of the positioning product accounts for 65%.
9. An accurate radiotherapy positioning product for tumor, comprising a first positioning product part and a second positioning product part, wherein the first positioning product part and the second positioning product part are printed by the printing and manufacturing method of any one of claims 1 to 8.
10. The precise tumor radiotherapy positioning product of claim 9, wherein the first product part and the second positioning product part are connected by a shaft.
CN201710309750.0A 2017-05-04 2017-05-04 3D individualized printing manufacturing method of accurate tumor radiotherapy positioning product and product thereof Active CN107137827B (en)

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CN108905003B (en) * 2018-04-08 2021-12-03 广东普能生物科技有限公司 3D radiotherapy positioning film generation method, electronic device, storage medium and system
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