CN107137466A - The preparation method of liver-protection health-care composition - Google Patents
The preparation method of liver-protection health-care composition Download PDFInfo
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- CN107137466A CN107137466A CN201710354908.6A CN201710354908A CN107137466A CN 107137466 A CN107137466 A CN 107137466A CN 201710354908 A CN201710354908 A CN 201710354908A CN 107137466 A CN107137466 A CN 107137466A
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- buckwheat
- liver
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of preparation method of liver-protection health-care composition, comprise the following steps：Carry out the extraction of flavones and buckwheat polysaccharide；After the buckwheat flavone of gained and buckwheat polysaccharide are crushed, cross after 80 mesh sieves, weigh buckwheat polysaccharide 10kg, buckwheat flavone 2.5kg, sesamin 100g, gossypose 2kg, be well mixed, plus appropriate dextrin, stir, 80% ethanol softwood, the granulation of 20 mesh sieves, dry to moisture and be no more than 8%, 10 mesh sieve whole grains, packing, every bag of 7g.The present invention is by optimization of C/C composites, and will take stopgap measures and effect a permanent cure is combined, and realizes recent relief of symptoms, and long term recovers the effect of liver function.
Description
Technical field
The present invention relates to health medicine field, and in particular to a kind of preparation method of liver-protection health-care composition.
Background technology
Alcoholic liver, full name is alcoholic fatty liver, is occurred earliest in AML, most commonly seen lesion.Alcohol
Liver is due to the hepar damnification disease caused by long-term heavy drinking or excessive drinking.Long-term wine-head 60~90% suffers from Alcoholic fat
Fat liver, alcoholic liver not only influences the synthesis of protein and vitamin to absorb (malnutrition), and malnutritive as liver cell
The secondary factors further damaged, influence each other the fatty infiltration for ultimately resulting in liver cell, inflammation, necrosis, liver fibrosis, liver
The generation of hardening.In addition, can also trigger multiple complications, these complication are often the hazards for causing alcoholic liver dead：
1. UGB：Portal hypertension caused by alcoholic liver, mostly occur UGB, it is also possible to due to urgency
Property gastric erosion, canker or esophageal varices bleeding (EVB), if timely and effectively can not handle and tackle, can go out
Situations such as now suffering a shock crisis life, dead probability is higher.
2. ascites and infection：Alcoholic liver causes a large amount of ascites occur because of factors such as electrolyte, osmotic pressure, nutrition, is similar to
The ascites of hepatic sclerosis and hepatocarcinoma patient, therefore cause vicious circle electrolyte disturbance or crisis whole system easily occur to cause
It is dead.Simultaneously because nutrition and various complication factors in the alcoholic liver course of disease, cause hypoimmunity easily to infect, particularly lung
Infect and bacillary spontaneous peritonitis in portion.The incidence of pneumonia is higher than in crowd 3-4 times, and is one of important cause of death,
Therefore it is prevented and treated should be in attention.
3. hepatic encephalopathy (hepatic coma)：Alcoholic liver patient Duo Yin hemorrhages of digestive tract, electrolyte and acid-base disturbance, secondary sense
Dye, etc. factor, complicated mechanism causes in itself with disease.If when occurring hepatic coma, rescue is improper or not in time, dead
Rate is high, should start with for alcoholic liver patient from prevention above risk factor, while active treatment alcoholic liver.
4. electrolyte disturbance, acid-base imbalance：Alcohol metabolism produces hyperlactacidemia, ketosis, causes AG (between anion
Gap) metabolic acidosis, ethanol, which excessively anaesthetizes suppression breathing, can cause respiratory acidosis, and alcohol withdrawal syndrome hyperpnea hyperventilation can cause to exhale
Absorption alkalosis.Simultaneously because take in less, drain acid-base disturbance caused by many, intestines and stomach and renal tubule malabsorption and ethanol,
There is electrolyte disturbance, occur low potassium, low magnesium, low calcium, hypophosphatemia etc., be to cause the major reason of death.
The ratio of China wine-head is significantly raised, and therefore the incidence of disease of alcoholic liver also significantly rises, and in rejuvenation trend,
Have become the second largest liver diseases for being only second to virus hepatitis.With the increase year by year for population of being addicted to drink, AML is
Through as role very important in hepatopathy family.The alcohol consumption speed fast 56% more increased than world other countries of China
Male and 15% women are on the drink, and men and women's percentage of wherein heavy drinking is respectively 51% and 63%, the percentage of excessive drinking
Than being respectively 57% and 27%.There is statistics to show, the alcoholic liver illness rate of white collar crowd and relatively rich crowd is up to 13~
24%.Cut-off 2011, China male alcoholic liver illness rate is 6.36%, and women is 0.36%；Male is addicted to drink crowd's alcoholic liver
Illness rate is 21.77%, and women is addicted to drink crowd 1.26%.Conservative estimation China alcoholic liver patient numbers should 50,000,000 or so,
As treated not in time, 60% alcohol hepatopath finally translates into hepatic sclerosis even liver cancer.
Existing hepatinica mainly has several classes such as yellow drop, drop enzyme, removing toxic substances.Showing as taking stopgap measures effect more, and long-term prescription has one
Determine adverse reaction, some medicines are also possible to cause liver function to rebound after being discontinued.
Polysaccharide has good anti-liver injury effect, is mainly damaged by Green Tea Extract, resists Calcium within hepatocytes overload, regulation
Mitochondrial function etc. plays anti-chemical damage effect, and by adjusting cell factor, suppressing complement system activity, suppression inflammation
Property medium produce, prevent hepatocellular apoptosis etc. play anti-immune hepatic injury effect.
Experimental studies have found that duck wheat polysaccharide has obvious scavenging action to DPPH free radicals.Under same concentrations, polysaccharide
V is significantly better than to the elimination effect of DPPH free radicalsCAnd VERemoving to DPPH free radicals.
Separately there is studies have shown that buckwheat polysaccharide to have significantly carbon tetrachloride, paracetamol induced mice acute liver damage
Protective effect.
Buckwheat flavone can reduce the death rate and Body weight loss rate of alcoholic liver injury mouse, suppress hepatic injury mouse
LI, AST and MDA, significantly increase hepatic injury murine liver tissue SOD activity, and the morphology for significantly improving alcohol damaged liver cell becomes
Change, the mechanism that its alcoholic liver injury has significant protective effect may be relevant with anti-lipid peroxidation damage.
Sesamin can significantly improve acute liver damage caused by paracetamol, mitigate the subacute hepatic injury caused by alcohol,
Reduce CCl4To the chronic injury of liver, suppress or delay the fibrosis of liver.Sesamin can make acute hepatic injury mice serum
ALT, GST are substantially reduced, and liver homogenate MDA contents are not only substantially less than model group, also less than normal group, illustrate that sesamin can make liver
Cytolipin extent of peroxidation substantially mitigates.Make the significantly rise of rats'liver SOD activity after sesamin long-time medication, point out sesame
Plain long-term prescription, antioxidation not only with short-term medication when direct effect of scavenging radical it is relevant, Shang Yuqi can improve SOD
Activity is relevant.Pathological examination is shown, sesamin is taken for a long time, can make animal pattern swelling of liver cell and steatosis degree
Mitigate.
Gossypose is neither degraded nor absorbed in small intestine, into large intestine just by Bifidobacterium and lactobacillus acidophilus profit
With promotion Bifidobacterium propagation, is the proliferation factor of Bifidobacterium.Cotton seed oligosaccharide can adjust bacterial equilibrium in enteron aisle, extensive
Multiple intestinal wall original state simultaneously forms protective layer, protects intestinal health.A large amount of generations of harmful substance in enteron aisle can be prevented, mitigate liver
Burden, so as to play a part of preventing and treat various hepatopathy diseases.
The content of the invention
To solve the above problems, the invention provides a kind of preparation method of liver-protection health-care composition, by taking stopgap measures and controlling
Originally it is combined, realizes recent relief of symptoms, long term recovers the effect of liver function.
To achieve the above object, the technical scheme taken of the present invention is：
The preparation method of liver-protection health-care composition, comprises the following steps：
S1, buckwheat or flowers and leaves of buckwheat are taken, crushed, plus 40%~90% ethanol, immersion, heating extraction, extract solution adds
The fining agents of ZTC- II, are stirred, and insulation is stood, filtering, filtrate decompression concentration, and concentrate adjusts pH value to acidity, and stirring is equal
It is even, stand, filtering, solid adds ethanol to dissolve, filter, filtrate recycling ethanol, remaining liq spray drying obtains buckwheat flavone；
S2, in the buckwheat after extracting buckwheat flavone Jia 0.1~1.5% salt solution, heating stirring extraction, extract solution adds
The fining agents of ZTC- II, are stirred, and insulation is stood, filtering, filtrate decompression concentration, plus 3~95% ethanol of 15 times of amounts, and stirring is equal
It is even, stand, filtering, solid is dissolved in water, plus 3~5 times of 80% ethanol of amount, stir, stand, filter, dry, obtain buckwheat many
Sugar；
S3, the buckwheat flavone of gained and buckwheat polysaccharide are crushed after, cross after 80 mesh sieves, weigh buckwheat polysaccharide 10kg, buckwheat
Flavones 2.5kg, sesamin 100g, gossypose 2kg, are well mixed, plus appropriate dextrin, stir, 80% ethanol softwood, 20
Mesh sieve is pelletized, and is dried to moisture and is no more than 8%, 10 mesh sieve whole grains, packing, every bag of 7g.
Wherein, the salt solution is sodium chloride, potassium chloride, sodium carbonate, sodium acid carbonate, sodium sulphate, potassium sulfate, sodium phosphate, phosphorus
Any in sour potassium, potassium carbonate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium nitrate, potassium nitrate
Kind.
The present invention is by optimization of C/C composites, and will take stopgap measures and effect a permanent cure is combined, and realizes recent relief of symptoms, and long term recovers liver function
Effect.
Embodiment
In order that objects and advantages of the present invention are more clearly understood, the present invention is carried out with reference to embodiments further
Describe in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
The embodiments of the invention provide a kind of preparation method of liver-protection health-care composition, comprise the following steps：
S1, buckwheat or flowers and leaves of buckwheat are taken, crushed, plus 40%~90% ethanol, immersion, heating extraction, extract solution adds
The fining agents of ZTC- II, are stirred, and insulation is stood, filtering, filtrate decompression concentration, and concentrate adjusts pH value to acidity, and stirring is equal
It is even, stand, filtering, solid adds ethanol to dissolve, filter, filtrate recycling ethanol, remaining liq spray drying obtains buckwheat flavone；
S2, in the buckwheat after extracting buckwheat flavone Jia 0.1~1.5% salt solution, heating stirring extraction, extract solution adds
The fining agents of ZTC- II, are stirred, and insulation is stood, filtering, filtrate decompression concentration, plus 3~95% ethanol of 15 times of amounts, and stirring is equal
It is even, stand, filtering, solid is dissolved in water, plus 3~5 times of 80% ethanol of amount, stir, stand, filter, dry, obtain buckwheat many
Sugar；
S3, the buckwheat flavone of gained and buckwheat polysaccharide are crushed after, cross after 80 mesh sieves, weigh buckwheat polysaccharide 10kg, buckwheat
Flavones 2.5kg, sesamin 100g, gossypose 2kg, are well mixed, plus appropriate dextrin, stir, 80% ethanol softwood, 20
Mesh sieve is pelletized, and is dried to moisture and is no more than 8%, 10 mesh sieve whole grains, packing, every bag of 7g, the 3g of polysaccharide containing buckwheat, buckwheat flavone
0.75g, sesamin 0.030g, gossypose 0.60g；1 bag every time, 3 times a day, warm boiled water.
The salt solution be sodium chloride, potassium chloride, sodium carbonate, sodium acid carbonate, sodium sulphate, potassium sulfate, sodium phosphate, potassium phosphate,
Any of potassium carbonate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium nitrate, potassium nitrate.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (2)
1. the preparation method of liver-protection health-care composition, it is characterised in that comprise the following steps：
S1, buckwheat or flowers and leaves of buckwheat are taken, crushed, plus 40%~90% ethanol, immersion, heating extraction, extract solution adds ZTC- II
Fining agent, is stirred, and insulation is stood, filtering, and filtrate decompression concentration, concentrate adjusts pH value to acidity, stirs, quiet
Put, filter, solid adds ethanol to dissolve, filter, filtrate recycling ethanol, remaining liq spray drying obtains buckwheat flavone；
S2, in the buckwheat after extracting buckwheat flavone Jia 0.1~1.5% salt solution, heating stirring extraction, extract solution adds ZTC- II
Fining agent, stirs, insulation stand, filtering, filtrate decompression concentration, plus 3~15 times amount 95% ethanol, stir, it is quiet
Put, filter, solid is dissolved in water, plus 3~5 times of 80% ethanol of amount, stir, stand, filter, dry, obtain buckwheat polysaccharide；
S3, the buckwheat flavone of gained and buckwheat polysaccharide are crushed after, cross after 80 mesh sieves, weigh buckwheat polysaccharide 10kg, buckwheat flavone
2.5kg, sesamin 100g, gossypose 2kg, are well mixed, plus appropriate dextrin, stir, 80% ethanol softwood, 20 mesh sieves
Granulation, dries to moisture and is no more than 8%, 10 mesh sieve whole grains, packing, every bag of 7g.
2. the preparation method of liver-protection health-care composition as claimed in claim 1, it is characterised in that the salt solution be sodium chloride,
Potassium chloride, sodium carbonate, sodium acid carbonate, sodium sulphate, potassium sulfate, sodium phosphate, potassium phosphate, potassium carbonate, disodium hydrogen phosphate, phosphoric acid hydrogen two
Any of potassium, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium nitrate, potassium nitrate.
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| CN201710354908.6A CN107137466A (en) | 2017-05-19 | 2017-05-19 | The preparation method of liver-protection health-care composition |
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| CN201710354908.6A CN107137466A (en) | 2017-05-19 | 2017-05-19 | The preparation method of liver-protection health-care composition |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045720A (en) * | 2007-03-20 | 2007-10-03 | 陕西师范大学 | Method for extracting buckwheat flavone from buckwheat shell |
| CN101829196A (en) * | 2010-05-26 | 2010-09-15 | 南京泽朗农业发展有限公司 | Preparation method of high-content buckwheat total flavone |
| CN102977218A (en) * | 2012-10-13 | 2013-03-20 | 内蒙古清谷新禾有机食品集团有限责任公司 | Method for extracting polysaccharide from buckwheat brans |
| CN106138240A (en) * | 2016-08-01 | 2016-11-23 | 四川农业大学 | A kind of extracting method of buckwheat total flavone |
-
2017
- 2017-05-19 CN CN201710354908.6A patent/CN107137466A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045720A (en) * | 2007-03-20 | 2007-10-03 | 陕西师范大学 | Method for extracting buckwheat flavone from buckwheat shell |
| CN101829196A (en) * | 2010-05-26 | 2010-09-15 | 南京泽朗农业发展有限公司 | Preparation method of high-content buckwheat total flavone |
| CN102977218A (en) * | 2012-10-13 | 2013-03-20 | 内蒙古清谷新禾有机食品集团有限责任公司 | Method for extracting polysaccharide from buckwheat brans |
| CN106138240A (en) * | 2016-08-01 | 2016-11-23 | 四川农业大学 | A kind of extracting method of buckwheat total flavone |
Non-Patent Citations (1)
| Title |
|---|
| 达胡白乙拉等: "荞麦花多糖的提取及含量测定", 《光谱实验室》 * |
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Application publication date: 20170908 |