CN107115506A

CN107115506A - A kind of plaster, preparation method and its application method for being used to treat insomnia

Info

Publication number: CN107115506A
Application number: CN201710462291.XA
Authority: CN
Inventors: 韩祖成
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-06-19
Filing date: 2017-06-19
Publication date: 2017-09-01

Abstract

A kind of plaster, preparation method and its application method for being used to treat insomnia of the present invention, belongs to pharmaceuticals industry, plaster of the invention is by following raw material：Cicada fungus powder, fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus seeds, lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, ganoderma lucidum, the red sage root, light wheat, Buddha's hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first).The present invention have good effect, cure rate it is high, using it is safe and free of toxic and side effects, easy to carry, be easy to preserve the characteristics of.

Description

A kind of plaster, preparation method and its application method for being used to treat insomnia

Technical field

The present invention relates to pharmaceutical technology field, more specifically to a kind of plaster, preparation side for being used to treat insomnia Method and its application method

Background technology

At present, treatment means both at home and abroad for insomnia (insomnia), are clinically substantially by calm, hypnosis class Pivot nervous system suppresses class medicine, Traditional Chinese Medicine decoction of medicinal ingredients, patent medicine, Chinese medicine acupuncture massage, psychotherapy, self-control and physiotherapy etc. Means are treated.It facts have proved：Calm, hypnotic drug has dependence, additive, and being excessively used can cause breathing to press down System, long-term taking can cause decrease of memory, absent minded；Traditional Chinese Medicine decoction of medicinal ingredients decoction method is bothered, and carries inconvenient, Influence patient adheres to the compliance for the treatment of for a long time；Chinese medicine nostrum is the mechanism such as transquilization with heavy material mostly, also simply cures the symptoms, not the disease, faces When relief of symptoms.The individual curative effect of Chinese medicine acupuncture, curative effect of massage is unstable, technical requirements are high, and being limited patient by consulting environment can not Adhere to for a long time；Psychotherapy is only applicable to using emotional factor as leading insomnia, treatment limitation and somewhat expensive；Self-control Method is only intended to insomnia initial stage and the lighter patient of the state of an illness, and treatment lacks specialist and instructed；Physiotherapy needs Medical treatment device mostly Tool is supported, is treated and is interrupted therewith after patient discharge, is interrupted after treatment, the state of an illness easily recurs.Therefore, finally finally, these Therapeutic scheme does not reach preferable therapeutic effect.

The content of the invention

It is an object of the invention to overcome defect present in existing treatment effectively to treat insomnia there is provided one kind (to lose Sleep) plaster, preparation method and its application method, this kind of herbal paste can long-term taking, conditioning viscera while symptom is improved, So as to play treatment and take good care of two big advantages, with good effect, cure rate it is high, using it is safe and free of toxic and side effects, easy to carry, The characteristics of being easy to preserve.

A kind of plaster for being used to treat insomnia of the present invention, includes the raw material of following mass parts：Cicada fungus powder, Fu God, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus seeds, lily, the fruit of Chinese magnoliavine, wheat Winter, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, ganoderma lucidum, the red sage root, light wheat, Buddha's hand, dried orange peel, mountain Short, bristly hair or beard, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first).

Further, the raw material of following mass parts is included：10-30 parts of cicada fungus powder, 100-200 parts of fushen, Radix Angelicae Sinensis 70-170 Part, 70-170 parts of the root of herbaceous peony, 40-130 parts of radix bupleuri, 100-200 parts of rhizoma atractylodis macrocephalae, 100-200 parts of cortex albiziae, 150-250 parts of spina date seed, 150-250 parts of the seed of Oriental arborvitae, 50-150 parts of polygala, 50-150 parts of arillus longan, 70-170 parts of lotus seeds, 70-170 parts of lily, the fruit of Chinese magnoliavine 50-150 parts, tuber of dwarf lilyturf 70-170 part, 10-90 parts of plum blossom, 50-150 parts of grass-leaved sweetflag, 50-150 parts of root tuber of aromatic turmeric, wilsonii 100-200 It is part, 70-170 parts of sealwort, 10-50 parts of Herba Hyperici Monogyni, 10-110 parts of rhizoma nardostachyos, 50-150 parts of ganoderma lucidum, 70-170 parts of the red sage root, floating small 100-200 parts of wheat, 50-150 parts of Buddha's hand, 50-150 parts of dried orange peel, 50-150 parts of hawthorn, 50-150 parts of jujube, honey-fried licorice root 10-110 Part, mother-of-pearl (are decocted first) 100-200 parts and (are decocted first) 100-200 parts with Os Draconis.

Further, the raw material of following mass parts is included：20 parts of cicada fungus powder, 150 parts of fushen, 120 parts of Radix Angelicae Sinensis, the root of herbaceous peony 120 Part, 90 parts of radix bupleuri, 150 parts of rhizoma atractylodis macrocephalae, 150 parts of cortex albiziae, 200 parts of spina date seed, 200 parts of the seed of Oriental arborvitae, 100 parts of polygala, arillus longan 100 parts, 120 parts of lotus seeds, 120 parts of lily, 100 parts of the fruit of Chinese magnoliavine, 120 parts of the tuber of dwarf lilyturf, 50 parts of plum blossom, 100 parts of grass-leaved sweetflag, root tuber of aromatic turmeric 100 Part, 150 parts of wilsonii, 120 parts of sealwort, 30 parts of Herba Hyperici Monogyni, 60 parts of rhizoma nardostachyos, 100 parts of ganoderma lucidum, 120 parts of the red sage root, light wheat 150 parts, 100 parts of Buddha's hand, 100 parts of dried orange peel, 100 parts of hawthorn, 100 parts of jujube, 60 parts of honey-fried licorice root, 150 parts of mother-of-pearl (being decocted first) and 150 parts of Os Draconis (being decocted first).

Further, the adjuvant of following mass fraction is included：100-200 parts of donkey-hide gelatin, 100-200 parts of walnut kernel, black sesame Numb 100-200 parts and 50-150 parts of maltose.

Further, the maltose can be substituted with xylitol or honey.

Further, the donkey-hide gelatin can be substituted with tortoise-shell glue.

Further, the adjuvant also includes yellow rice wine, and the yellow rice wine is that volume parts are 200-400 parts.

A kind of preparation method for being used to treat the plaster of insomnia of the present invention, comprises the following steps：

Soak medicine：By fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus Son, lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, the red sage root, light wheat, Buddha's hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first) mixing are poured into container, in a reservoir Add water immersion and obtain soak；

Decoct precipitation：Above-mentioned soak is added water to cook and obtains decoction liquor, raw material must be impregnated with after liquid precipitate being decocted；

Extract：Raw material will be impregnated with boil and take first time decoction, the continuation that adds water decocts to obtain second of decoction, and merge medicine twice Liquid, the dregs of a decoction extrude concoction and added in decoction amalgamation liquid twice, the decoction after must being precipitated after precipitation；

Small fire, which is decocted, after decoction after precipitation is boiled by fire keeps micro-boiling, and stirring removes the foam for floating on surface, decocts Filtered to get filtrate after 1-2 hours, the dregs of a decoction are continuous plus cold water is decocted again, such as method is decocted three times, and merging filtrate is staticly settled, then with three layers Above filtered through gauze obtains decoction 2-4 times；

Concentration：Cicada fungus powder is added after decoction is sieved and is heated, offscum is skimmed；Continue to heat and stir until decoction is formed Paste, paste decoction is dripped in drying on mulberry paper, obtain concentrating ointment with chopsticks or bamboo weaving；

Ganoderma lucidum is soaked：Ganoderma lucidum is added water ganoderma lucidum extract is decocted to obtain with small fire；

Receive cream：Ganoderma lucidum extract and concentration ointment are sufficiently stirred for obtaining cream taste；Cream is grown and is quickly poured into what is sterilized while hot In container, packing cooling is carried out, you can.

Further, comprise the following steps：

Soak medicine：By fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus Son, lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, the red sage root, light wheat, Buddha's hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first) mixing are poured into container, in a reservoir Water immersion is added, water is higher by powder 12-18cm, and immersion 2h obtains soak；

Donkey-hide gelatin and tortoise-shell glue are put into yellow rice wine and soak deodorization, mixed liquor is obtained after being swelled；

Extract：Raw material will be impregnated with and boil taking-up first time decoction after 2h, the continuation that adds water, which is decocted, obtains second of decoction after 1h, close And decoction twice, the dregs of a decoction extrude concoction and simultaneously add in decoction amalgamation liquid twice, the decoction after must being precipitated after precipitation 6h；

Concentration：By decoction through 80 mesh medicine sievings after put in red copper medicine pot, add cicada fungus powder, be heated to boiling, skim offscum； Continue to heat and stir until decoction formation paste, paste decoction is dripped in drying on mulberry paper, obtain with chopsticks or bamboo weaving Concentrate ointment；

Receive cream：The mixed liquor obtained after leaching medicine is added in concentrate, breaks and stirs to the complete molten of blob of viscose, then through 60 mesh medicines Sieving, pours into red copper medicine pot continuation heating stirring to concoction and drips in line or post；Ganoderma lucidum extract is fully stirred with concentration ointment Mix and obtain cream taste；Cream is grown and is quickly poured into while hot in the container sterilized, packing cooling is carried out, you can.

A kind of application method for being used to treat the plaster of insomnia of the present invention, on an empty stomach and will sleep preceding 1 from plaster morning Hour take, 1 spoonful of common soupspoon or 2 times a day holding in the mouth or the eyes.

Beneficial effects of the present invention are as follows：

1. reasonable recipe, using safety, drugloading rate is big, efficient, have no toxic side effect；

2. raw material is essentially common medicine, reasonable price, and preparation method simply, with low cost；

3. present invention conditioning viscera while symptom is improved, so as to play treatment and take good care of two big advantages, with curative effect Good, cure rate is high, using it is safe and free of toxic and side effects, easy to carry, be easy to preserve the characteristics of.

4. therapeutic domain of the present invention is wide, the insomnia patient of various, various healths can be used.

Embodiment

Come to be further elaborated a kind of plaster of facial paralysis of the present invention by the following examples：

Embodiment 1

A kind of plaster for being used to treat insomnia, includes the raw material of following mass parts：Cicada fungus powder 10-30g, fushen 100- 200g, Radix Angelicae Sinensis 70-170g, root of herbaceous peony 70-170g, radix bupleuri 40-130g, rhizoma atractylodis macrocephalae 100-200g, cortex albiziae 100-200g, spina date seed 150-250g, seed of Oriental arborvitae 150-250g, polygala 50-150g, dragon, eye meat 50-150g, lotus seeds 70-170g, lily 70-170g, five Taste 50-150g, tuber of dwarf lilyturf 70-170g, plum blossom 10-90g, grass-leaved sweetflag 50-150g, root tuber of aromatic turmeric 50-150g, wilsonii 100-200g, Sealwort 70-170g, Herba Hyperici Monogyni 10-50g, rhizoma nardostachyos 10-110g, ganoderma lucidum 50-150g, red sage root 70-170g, light wheat 100- 200g, Buddha's hand 50-150g, dried orange peel 50-150g, hawthorn 50-150g, jujube 50-150g, honey-fried licorice root 10-110g, mother-of-pearl are (first Decocting) 100-200g and Os Draconis (are decocted first) 100-200g.

Also include the adjuvant of following quality g numbers：Donkey-hide gelatin 100-200g, walnut kernel 100-200g, Semen sesami nigrum 100-200g and Maltose 50-150g.

Above-mentioned maltose can be substituted with xylitol or honey.

The donkey-hide gelatin can be substituted with tortoise-shell glue.

Above-mentioned adjuvant also includes yellow rice wine, and the yellow rice wine is that volume parts are 200-40ml.

The dispensing of carbohydrate and glue class, all should be selected as needed, such as cloudy deficiency of blood weak person, can select tortoise-shell glue；Asthenia of qi and blood Weak person, can select donkey-hide gelatin glue；Constipation person can add honey；Diabetic can select maltose；Liver patient can be without yellow rice wine impregnation etc..

A kind of preparation method for being used to treat the plaster of insomnia, comprises the following steps：

Soak medicine：By fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus Son, lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, the red sage root, light wheat, Buddha's hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first) mixing are poured into container, in a reservoir Water immersion is added, water is higher by powder 12-18cm, fully immersion 2h obtains soak；

After raw material is well mixed, it is put into the container of lid, container is red copper medicine pot.Then add wherein in right amount Cold water (pure water) soaks, and it is degree to be typically higher by 15 centimetres of powder with water, soak time about 2 hours or so, make medicine effectively into Divide and be substantially soluble in clear water.

Meanwhile, if auxiliary material, then meat or fish cream (donkey-hide gelatin, tortoise-shell glue) is put into yellow rice wine and soaks deodorization, after meat or fish cream is swelled Add in the decoction after concentration.

Using multiple filtered through gauze, the impurity in decoction is reduced as far as possible.

Concentration：By decoction through 80 mesh medicine sievings after put in red copper medicine pot, add cicada fungus powder, be heated to boiling, skim offscum； Continue to heat and constantly stir decoction with chopsticks or bamboo weaving, prevent coking, stirring until decoction gradually forms paste, while hot Paste decoction is dripped in drying on mulberry paper with chopsticks or bamboo weaving, water mark is loseed around cream as degree to drip.This meaning clear cream.Obtain dense Contracting ointment；

, then should not be same pan-fried with his medicine because ganoderma lucidum is valuable drug, in order to avoid cause to waste, it should extract is separately decocted with small fire, Concoction is poured when cream is received.Cicada fungus is ground into fine powder, can be called in when cream is received in cream also, can so give full play to its medicine Effect.

The process of cooling, is also important link.Such as collect improper, easily mildew is gone bad, and influences drug effect.This kind of herbal paste is deposited It is placed in sterilization vial.Herbal paste of the present invention can generally be taken 12-20 weeks, so the environment placed is preferably shady and cool dry, such as Keep away in place of sun or in refrigerator, because sugared part content is high in herbal paste, and wherein also contain animal protein, the high hair apt to deteriorate of temperature one It is mould.

Application method：On an empty stomach and it will sleep first 1 hour and take from plaster morning, 1 spoonful of common soupspoon or 2 times a day holding in the mouth or the eyes.

Jelly and the proper honeys such as donkey-hide gelatin, tortoise-shell glue are added in the decoction of paste or maltose is decocted and continuous with small fire It is exactly to receive cream with chopsticks stirring and even process.The dispensing of carbohydrate and glue class, all should be selected as needed, such as the cloudy deficiency of blood is weak Person, can select tortoise-shell glue；Asthenia of qi and blood weak person, can select donkey-hide gelatin glue；Constipation person can add honey；Diabetic can select maltose； Liver patient can be without yellow rice wine impregnation etc..In this course, Special attention will be given to " drop medicine such as post " and " planting flag " two special nouns. So-called " drop medicine such as post ", exactly describes the viscous pasty state that whole decoction shows after boiling." planting flag ", then refer to passing through " after drop medicine Cheng Zhu " state, be trapped in bamboo it is flat on the flag shape small one by one that is formed by Action of Gravity Field of decoction Shape.Both of these case is generally occurred within, just illustrates that this cream wetting drug has been manufactured soon.

The medicine of above-mentioned treatment insomnia be come from the Nature, green, environmental protection, rare, genuine Chinese medicine be raw material The preparation being made, preferably herbal paste.Medicine of the present invention has：1. Clinical practice is proved, using safety, and drugloading rate is big, efficient, nothing Toxic side effect；2. raw material is common medicine, reasonable price, and is prepared superior；3. it is easy to carry, it is easy to preserve；4. instructions of taking Simplicity, the micro- sweet tea of taste, it is easy to entrance；5. observed through a large amount of Clinical practices, generally, trial edition herbal paste can be alleviated for 4-8 weeks Symptom, sleep can be obviously improved by being continuing with the time of 3-6 months, and recurrence rate is extremely low, curative effect can stablize 3-5 years with On.

Embodiment 2

A kind of plaster for being used to treat insomnia, includes the raw material of following mass parts：Cicada fungus powder 10g, fushen 100g, Radix Angelicae Sinensis 70g, root of herbaceous peony 70g, radix bupleuri 40g, rhizoma atractylodis macrocephalae 100g, cortex albiziae 100g, spina date seed 150g, seed of Oriental arborvitae 150g, polygala 50g, longan Meat 50g, lotus seeds 70g, lily 70g, fruit of Chinese magnoliavine 50g, tuber of dwarf lilyturf 70g, plum blossom 10g, grass-leaved sweetflag 50g, root tuber of aromatic turmeric 50g, wilsonii 100g, Sealwort 70g, Herba Hyperici Monogyni 10g, rhizoma nardostachyos 10g, ganoderma lucidum 50g, red sage root 70g, light wheat 100g, Buddha's hand 50g, dried orange peel 50g, hawthorn 50g, jujube 50g, honey-fried licorice root 10g, mother-of-pearl (are decocted first) 100g and Os Draconis (are decocted first) 100g.

Embodiment 3

A kind of plaster for being used to treat insomnia, includes the raw material of following mass parts：Cicada fungus powder 20g, fushen 150g, Radix Angelicae Sinensis 120g, root of herbaceous peony 120g, radix bupleuri 90g, rhizoma atractylodis macrocephalae 150g, cortex albiziae 150g, spina date seed 200g, seed of Oriental arborvitae 200g, polygala 100g, dragon Eye meat 100g, lotus seeds 120g, lily 120g, fruit of Chinese magnoliavine 100g, tuber of dwarf lilyturf 120g, plum blossom 50g, grass-leaved sweetflag 100g, root tuber of aromatic turmeric 100g, thorn Slender acanthopanax 150g, sealwort 120g, Herba Hyperici Monogyni 30g, rhizoma nardostachyos 60g, ganoderma lucidum 100g, red sage root 120g, light wheat 150g, Buddha's hand 100g, dried orange peel 100g, hawthorn 100g, jujube 100g, honey-fried licorice root 60g, mother-of-pearl (are decocted first) 150g and Os Draconis (are decocted first) 150g.

Further, in addition to auxiliary material：Yellow rice wine 300ml, donkey-hide gelatin 150g, walnut kernel 150g, Semen sesami nigrum 150g, maltose 100g。

Further, donkey-hide gelatin can be substituted with tortoise-shell glue, and maltose can be substituted with xylitol or honey.

Small fire, which is decocted, after decoction after precipitation is boiled by fire keeps micro-boiling, and stirring removes the foam for floating on surface, decocts 2 Filtered to get filtrate after hour, the dregs of a decoction are continuous plus cold water is decocted again, such as method is decocted three times, and merging filtrate is staticly settled, then with more than 4 layers Filtered through gauze obtains decoction 3 times；

Receive cream：The mixed liquor obtained after leaching medicine is added in concentrate, is stirred continuously to the complete molten of blob of viscose, then through 60 mesh Medicine sieving, pours into red copper medicine pot continuation heating stirring to concoction and drips in line or post；Ganoderma lucidum extract and concentration ointment is abundant Stirring obtains cream taste；Cream is grown and is quickly poured into while hot in the container sterilized, packing cooling is carried out, you can.

Embodiment 4

A kind of plaster for being used to treat insomnia, includes the raw material of following mass parts：Cicada fungus powder 30g, fushen 200g, Radix Angelicae Sinensis 170g, root of herbaceous peony 170g, radix bupleuri 130g, rhizoma atractylodis macrocephalae 200g, cortex albiziae 200g, spina date seed 250g, seed of Oriental arborvitae 250g, polygala 150g, Arillus longan 150g, lotus seeds 170g, lily 170g, fruit of Chinese magnoliavine 150g, tuber of dwarf lilyturf 170g, plum blossom 90g, grass-leaved sweetflag 150g, root tuber of aromatic turmeric 150g, Wilsonii 200g, sealwort 170g, Herba Hyperici Monogyni 50g, rhizoma nardostachyos 110g, ganoderma lucidum 150g, red sage root 170g, light wheat 200g, Buddha's hand 150g, dried orange peel 150g, hawthorn 150g, jujube 150g, honey-fried licorice root 110g, mother-of-pearl (are decocted first) 200g and Os Draconis (being decocted first) 200g。

Small fire, which is decocted, after decoction after precipitation is boiled by fire keeps micro-boiling, and stirring removes the foam for floating on surface, decocts 1 Filtered to get filtrate after hour, the dregs of a decoction are continuous plus cold water is decocted again, such as method is decocted three times, and merging filtrate is staticly settled, then with more than three layers Filtered through gauze obtains decoction 4 times；

The clinical research data of insomnia is treated using 2-4 of the embodiment of the present invention

(1) general information

Herbal paste of the present invention is used for 2653 patients of clinical treatment, wherein, man 1068, female 1585；Age 18--75 Sui, Course of disease 1--3 683,4--7 1441, more than 8 years 529 (wherein the course of disease up to more than 10 years 172).

Above-mentioned patient is all diagnosed as insomnia (insomnia) according to symptom and sleep analysis monitor.

(2) diagnostic criteria：Reference《Chinese Spirit Obstacles classification and the diagnostic criteria third edition》Middle nonorganic insomnia system Fixed standard setting：

1. symptom standard：

A. it is simple to have a sleepless night for only symptom, it is main cash as difficulty falling asleep, shallow dreaminess early awakening of sleeping, wake up after it is difficult sleep and wake up after Fatigue and weak, influences the life etc. that works by day.

B. the idea of insomnia and insomnia result is extremely paid close attention to.

2. serious standard：

It is undermined to the length of one's sleep, number of times, the obvious worried mood of the dissatisfied appearance of quality and social functional activity.

3. course of disease standard：

Had a sleepless night >=3 times in 7 days, the course of disease >=January.

4. exclusion standard：

Insomnia secondary caused by the organic, corporality of exclusion, phrenoblabia disease.

Note：Include insomnia not in the phrenoblabia symptoms such as some corporality diseases or neurasthenia, depression Insomnia is separately diagnosed as again.

(3) treatment method：Half an hour is oral on an empty stomach and before sleeping from morning, 1 5g (about 1), containing change.

(4) efficacy assessment standard：Formulated according to health ministry in 1993《New Chinese medicine guideline of clinical investigations The guideline of clinical investigations of new Chinese medicine treatment insomnia》^[31]CGI (CGI) is coordinated to make overall evaluation.

Clinical recovery：Nighttime sleep >=6h or Nighttime sleep recover normal, and it is sedate to sleep, and energy is satisfied after waking up It is full；

It is effective：Sleep has more apparent improvement, and the length of one's sleep extends more than 3h, Depth of sleep increase earlier above；

Effectively：Symptom is alleviated earlier above, and the length of one's sleep extends less than 3h earlier above；

It is invalid：Symptom is without improvement or aggravation person after treatment.

(5) treatment results (see the table below 1, table 2 and table 3)

The treatment time of table 1 and observation of curative effect

Treatment time	Cure	Take a turn for the better	It is effective	It is invalid
					1 month	253	1009	1289	102
2 months	314	1225	1052	62
					3 months	286	1543	801	23

The observation of curative effect after treatment of table 2

The sign after treatment of table 3 improves situation

Symptom	Difficulty falling asleep	Early awakening	Sleep simple and easy awake	Dreaminess
					Before treatment (example)	1552	263	316	522
After treatment (example)	102	60	49	25
					Total effective rate	93.4%	77.2%	84.5%	95.2%

In a word, above-mentioned insomnia patient is treated with the present invention, cures 284, effective 1047, take a turn for the better 1259, it is invalid 62；Cure rate 10.7%, obvious effective rate 39.5%, improvement rate 47.5%, effective percentage 97.7%, inefficiency 2.3%.

Up to the present, specific typical case used in the present invention has：

Case one：Mu Xuanmin, female, 63 years old, retired personnel, in March, 2014 went to a doctor

There is difficulty falling asleep before 20 years without obvious inducement in patient, and Yi Xing is difficult to fall asleep again after waking up, with dreaminess, early awakening, Once went to a doctor in " Chang'an county hospital ", be diagnosed as " insomnia "." diazepam injection 1 is taken before sleeping " assisting sleep is taken, from morning It is still drank after a night sense, symptom is repeatedly after being voluntarily discontinued.Interruption oral " diazepam injection ", " Alprazolamum " unsatisfactory curative effect.The past body is good for.Closely 2 months, patient falls asleep's difficulty was aggravated, or even is insomnia all night, with episodic vertigo.It is medical on March 12nd, 2014, it is rear with the present invention Herbal paste is treated January, and daily sleep can be maintained 4 hours or so, and daydream is significantly reduced.Adhere to taking herbal paste of the present invention after 2 months, fall asleep Fast earlier above, sleep is maintained 5-6 hours, occasionally has daydream, mood takes a turn for the better earlier above, and the daytime is without weak sense.

Case two：Yun Hang, man, 23 years old, student, in June, 2015 went to a doctor

Patient had a sleepless night before 4 years because college entrance examination pressure is excessive, with depressed, is reluctant to exchange with people, once took " fluorine piperazine thiophene Ton melitracen piece " 1 year, drug withdrawal of being followed the doctor's advice after remission.Immediate cause face graduation pressure it is excessive, have a sleepless night again, patient Refuse western medicine, because go to school can not decoction decoction, then advise take herbal paste of the present invention.When patient takes further consultation in 14 days, mood Pleasure, private prosecution difficulty falling asleep is alleviated substantially, still early awakening, is difficult to fall asleep again after waking up.It is recommended that continuing to take herbal paste of the present invention.January Afterwards, patient symptom disappears, and is in a cheerful frame of mind.

Case three：Wang Xiangqin, female, 54 years old, peasant, in November, 2015 went to a doctor

Patient's cause in January is quarreled with neighbours, and night is unable to fall asleep long, occurs nervous, uncomfortable in chest, bitter taste from morning next day, and weight is not given Depending on.Fall asleep every night afterwards many bad dreams, family members tell and talk in one's sleep every night, toss about.In November, 2015 goes to a doctor, and patient's mind is clear, spirit Difference, falls asleep fine, night many bad dreams, normal night sweat, dry mouth with bitter taste from morning, receives difference, and stool is dry, and urine is adjusted.Take herbal paste January of the present invention Afterwards, patient's night sweat is reduced, and bitter taste dry is alleviated.Following the service herbal paste of the present invention, after 2 months, patient's bad dream is reduced, and spirit takes a turn for the better.

Case four：Wang Jianmin, man, 76 years old, retired personnel, in October, 2016 went to a doctor

Patient is weak and sickly when young, catches a cold often, sleeps usually poor, interruption take " tranquilizing and allaying excitement class " medicine and in Medicine, it is bad when good during symptom.There is difficulty falling asleep in gall stone Post operation before January, and sleep is simple and easy to wake up with a start, and shortness of breath and fatigue is easily frightened, food It is intended to depressed.Take traditional Chinese medicine decoction, and entrance is to tell.It is required that changing formulation.Take after herbal paste of the present invention, feel the micro- sweet tea of entrance, daily can be hard Hold and take.Further consultation after 7 days, shortness of breath and fatigue remission.Further consultation after 2 weeks, fear mitigates, and falls asleep fine.After March, symptom base This disappearance.

The plaster of the present invention has the following effects that：

1st, sleep is promoted：Difficulty falling asleep has following reason from traditional Chinese medical science angle：1. the insomnia of heart spleen syndrome of deficiency of both qi and blood, shows as Palpitation and severe palpitation, forgetful insomnia, night sweat, the tired deficiency of food of body, sallow complexion, pale tongue, tongue is thin white, and arteries and veins is thin and delicate；2. heart-liver blood deficiency and cause void Tired insomnia, shows as dysphoria insomnia, dry throat, tongue is red, small and wiry pulse.3. the insomnia caused by hepatic depression and blood deficiency spleen is weak, shows as Two sides of body have a pain, headache and dizziness, dryness of the mouth and throat, mental fatigue with loss of appetite, or irregular menstruation, swollen breasts, veins string and void person.4. liver kidney is not Insomnia caused by foot, shows as insomnia and dreamful sleep, soreness and weakness of waist and knees is dysphoria in chestpalms-soles, warms night sweat, and vertigo, the empty pain of head, two mesh are done Puckery, tongue body is thin and red, lacks tongue or without tongue, buys string thin and delicate.Herbal paste of the present invention is in classical Chinese medicine side's guipi decoction, suanzaoren decoction, carefree Dissipate and added and subtracted on the basis of waiting, the common insomnia card type of above-mentioned modern can be effectively improved, play following therapeutic action：1. in Pivot nervous system sedation, shortens dropping asleep latency；2. improve anxiety, depressive state, nurse one's health human functional activity of vital energy, induced hypnotic.

2nd, correction is cured a disease, and recovers normal sleep period.Herbal paste of the present invention focuses on overall conditioning yin-Yang comprehensively, defends battalion Before press rule circulation, negative and positive according to when come in and go out, make human body recover normal sleep period.

3rd, sleep quality is improved, shortens fast quick-action eye phase sleep.

4th, treatment spontaneous perspiration, night sweat, convulsions.

5th, forgetful, decrease of memory, soreness and weakness of waist and knees are treated, it is dysphoria in chestpalms-soles.

6th, the therapeutic domain of plaster of the present invention is：

1st, insomnia.It is mainly used in difficulty falling asleep, sleeps and maintain obstacle, the disease such as dreaminess.

2nd, mild anxiety, depressed caused agitation, irritability, pessimism, happiness are sighed.

3rd, it is shortness of breath caused by having not enough sleep, spontaneous perspiration, weak.

4th, senile forgetful, decrease of memory.

The Chinese medicine that the plaster of the present invention is used is the cicada fungus powder through selecting meticulously, Herba Hyperici Monogyni, fushen, ganoderma lucidum, Ah The pleasant impression rare medicinal herbs of glue etc. 40 is the pure Chinese medicine herbal paste that primary raw material is made.Said medicine is carried out to cause each medicine after science combination Thing effect produces synergy, with antitoxic heart-soothing and sedative, soothing the liver reason spleen, tonifying kidney and benefiting sperm effect.So as to reach the extension length of one's sleep, carry High sleep quality, the effect for alleviating anxiety.Wherein select through thousands of clinical test and clinical observations repeatedly, successfully develop Go out cicada fungus powder (genunie medicinal materials originated from the free of contamination original bamboo grove of Hengduan mountain range or temmoku mountain range,《Sheng Nong's herbal classic》Deng Ancient books is recorded：" (gold) cicada fungus, it is rare, be born in the peak-to-peak recess in the south of the Five Ridges, day flickering Mi Zhulinchu, mist is curled up, on fallen with thickness Leaf covers it, goes out after rain, it is seen that spend in vain, six July person it is good, bitter bamboo cicada person is good, it is medicinal it, have special effect, take it, can not always, body is light, Promote longevity ", not yet there is the relevant report for treating insomnia for the prescription of monarch using this medicine the country at present).The medicine has solution Effect that heat is calmed the nerves, calming heart is relieving convulsion, can extend the length of one's sleep caused by yellow Jackets and chloraldurate；Ganoderma lucidum has calm pacify God, the effect of QI invigorating replenishing essence；Fushen has strengthening the spleen and replenishing qi, antitoxic heart-soothing and sedative curative effect；Herba Hyperici Monogyni is used for soothing liver-qi stagnation, qi-regulating peace God；Radix Angelicae Sinensis is for replenishing blood for nourishing heart, promoting blood circulation and removing blood stasis.

In order to reach more preferable therapeutic effect, medicine of the present invention is also combined with spina date seed, the seed of Oriental arborvitae, cortex albiziae, lily.This It is because according to modern study, this four traditional Chinese medicine thing all has the effect of antitoxic heart-soothing and sedative, while spina date seed also holds back the moon for nourishing heart, controls Treat dysphoria and insomnia, spontaneous sweating；Cortex albiziae treatment is confused and worried, melancholy insomnia；Lily is used for heart fire-clearing upset-relieving.

In order to obtain optimum curative effect, the present invention is additionally added wilsonii, sealwort, jujube on the basis of said medicine.This be because For the filling liver kidney of wilsonii energy, promoting blood circulation arteries and veins；Sealwort can reinforce the spleen to benefit the lung, Zishen fill fine；Jujube is sweet slow, being capable of tonifying middle-Jiao and Qi, nourishing heart Calm the nerves.Tortoise-shell glue draws sun and enters the moon, and the root of herbaceous peony holds back cloudy and battalion, amounts to balance between YIN and YANG.In addition the plum of soothing the liver promoting the circulation of qi is also added in the herbal paste Flower, Buddha's hand, grass-leaved sweetflag, root tuber of aromatic turmeric, transquilization with heavy material mother-of-pearl, Os Draconis etc., 40 pleasant impression Chinese medicine cooperative compensatings, play altogether it is sleeping it Effect.

Claims

1. a kind of plaster for being used to treat insomnia, it is characterised in that include the raw material of following mass parts：Cicada fungus powder, fushen, when Return, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus seeds, lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum It is flower, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, ganoderma lucidum, the red sage root, light wheat, Buddha's hand, dried orange peel, hawthorn, big Jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first).

2. a kind of plaster for being used to treat insomnia, it is characterised in that include the raw material of following mass parts：10-30 parts of cicada fungus powder, 100-200 parts of fushen, 70-170 parts of Radix Angelicae Sinensis, 70-170 parts of the root of herbaceous peony, 40-130 parts of radix bupleuri, 100-200 parts of rhizoma atractylodis macrocephalae, cortex albiziae 100-200 parts, 150-250 parts of spina date seed, 150-250 parts of the seed of Oriental arborvitae, 50-150 parts of polygala, 50-150 parts of arillus longan, lotus seeds 70- 170 parts, it is 70-170 parts of lily, 50-150 parts of the fruit of Chinese magnoliavine, tuber of dwarf lilyturf 70-170 part, 10-90 parts of plum blossom, 50-150 parts of grass-leaved sweetflag, strongly fragrant Golden 50-150 parts, 100-200 parts of wilsonii, 70-170 parts of sealwort, 10-50 parts of Herba Hyperici Monogyni, 10-110 parts of rhizoma nardostachyos, ganoderma lucidum 50-150 parts, 70-170 parts of the red sage root, 100-200 parts of light wheat, 50-150 parts of Buddha's hand, 50-150 parts of dried orange peel, 50-150 parts of hawthorn, 50-150 parts of jujube, 10-110 parts of honey-fried licorice root, mother-of-pearl (are decocted first) 100-200 parts and (are decocted first) 100-200 parts with Os Draconis.

3. a kind of plaster for being used to treat insomnia according to claim 1, it is characterised in that including following mass parts Raw material：20 parts of cicada fungus powder, 150 parts of fushen, 120 parts of Radix Angelicae Sinensis, 120 parts of the root of herbaceous peony, 90 parts of radix bupleuri, 150 parts of rhizoma atractylodis macrocephalae, cortex albiziae 150 Part, 200 parts of spina date seed, 200 parts of the seed of Oriental arborvitae, 100 parts of polygala, 100 parts of arillus longan, 120 parts of lotus seeds, 120 parts of lily, the fruit of Chinese magnoliavine 100 parts, 120 parts of the tuber of dwarf lilyturf, 50 parts of plum blossom, 100 parts of grass-leaved sweetflag, 100 parts of root tuber of aromatic turmeric, 150 parts of wilsonii, 120 parts of sealwort, pass through leaf spun gold 30 parts of peach, 60 parts of rhizoma nardostachyos, 100 parts of ganoderma lucidum, 120 parts of the red sage root, 150 parts of light wheat, 100 parts of Buddha's hand, 100 parts of dried orange peel, hawthorn 100 150 parts of part, 100 parts of jujube, 60 parts of honey-fried licorice root, 150 parts of mother-of-pearl (being decocted first) and Os Draconis (being decocted first).

4. a kind of plaster for being used to treat insomnia according to claim 1, it is characterised in that also including following mass parts Several adjuvants：50-150 parts of 100-200 parts of donkey-hide gelatin, 100-200 parts of walnut kernel, 100-200 parts of Semen sesami nigrum and maltose.

5. a kind of plaster for being used to treat insomnia according to claim 4, it is characterised in that the maltose can use xylose Alcohol or honey are substituted.

6. a kind of plaster for being used to treat insomnia according to claim 4, it is characterised in that the donkey-hide gelatin can use tortoiseshell Glue is substituted.

7. a kind of plaster for being used to treat insomnia according to claim 4, it is characterised in that the adjuvant also includes Huang Wine, the yellow rice wine is that volume parts are 200-400 parts.

8. according to claim 1 it is a kind of be used for treat insomnia plaster preparation method, it is characterised in that including following Step：

Soak medicine：By fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus seeds, Lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, the red sage root, light wheat, Buddhist Hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first) mixing are poured into container, are added in a reservoir Enter water immersion and obtain soak；

Extract：Raw material will be impregnated with boil and take first time decoction, the continuation that adds water decocts to obtain second of decoction, and merge decoction, medicine twice Slag extrudes concoction and added in decoction amalgamation liquid twice, the decoction after must being precipitated after precipitation；

Small fire, which is decocted, after decoction after precipitation is boiled by fire keeps micro-boiling, and stirring removes the foam for floating on surface, decocts 1-2 small When after filter to get filtrate, the dregs of a decoction are continuous plus cold water is decocted again, and such as method is decocted three times, and merging filtrate is staticly settled, then with more than three layers yarns Cloth filters 2-4 times and obtains decoction；

Concentration：Cicada fungus powder is added after decoction is sieved and is heated, offscum is skimmed；Continue to heat and stir until decoction formation thick paste Shape, paste decoction is dripped in drying on mulberry paper, obtain concentrating ointment with chopsticks or bamboo weaving；

Receive cream：Ganoderma lucidum extract and concentration ointment are sufficiently stirred for obtaining cream taste；Cream is grown to the container for being quickly poured into sterilized while hot It is interior, carry out packing cooling, you can.

9. it is according to claim 8 it is a kind of be used for treat insomnia plaster preparation method, it is characterised in that including with Lower step：

Soak medicine：By fushen, Radix Angelicae Sinensis, the root of herbaceous peony, radix bupleuri, rhizoma atractylodis macrocephalae, cortex albiziae, spina date seed, the seed of Oriental arborvitae, polygala, arillus longan, lotus seeds, Lily, the fruit of Chinese magnoliavine, the tuber of dwarf lilyturf, plum blossom, grass-leaved sweetflag, root tuber of aromatic turmeric, wilsonii, sealwort, Herba Hyperici Monogyni, rhizoma nardostachyos, the red sage root, light wheat, Buddhist Hand, dried orange peel, hawthorn, jujube, honey-fried licorice root, mother-of-pearl (being decocted first) and Os Draconis (being decocted first) mixing are poured into container, are added in a reservoir Enter water immersion, water is higher by powder 12-18cm, and immersion 2h obtains soak；

Extract：Raw material will be impregnated with and boil taking-up first time decoction after 2h, the continuation that adds water, which is decocted, obtains second of decoction after 1h, merge two Secondary decoction, the dregs of a decoction extrude concoction and added in decoction amalgamation liquid twice, the decoction after must being precipitated after precipitation 6h；

Concentration：By decoction through 80 mesh medicine sievings after put in red copper medicine pot, add cicada fungus powder, be heated to boiling, skim offscum；Continue Heat and stir until decoction formation paste, paste decoction is dripped in drying on mulberry paper, concentrated with chopsticks or bamboo weaving Ointment；

Receive cream：The mixed liquor obtained after leaching medicine is added in concentrate, is stirred continuously to the complete molten of blob of viscose, then is sieved through 60 mesh medicines Filtration, pours into red copper medicine pot continuation heating stirring to concoction and drips in line or post；Ganoderma lucidum extract is sufficiently stirred for concentration ointment Obtain cream taste；Cream is grown and is quickly poured into while hot in the container sterilized, packing cooling is carried out, you can.

10. according to claim 1 it is a kind of be used for treat insomnia plaster application method, it is characterised in that：By plaster On an empty stomach and sleep first 1 hour and take from morning, 1 spoonful of common soupspoon or 2 times a day holding in the mouth or the eyes.