CN107109371A - 皮钦德病毒反向遗传学系统及其使用方法 - Google Patents

皮钦德病毒反向遗传学系统及其使用方法 Download PDF

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Publication number
CN107109371A
CN107109371A CN201580063072.3A CN201580063072A CN107109371A CN 107109371 A CN107109371 A CN 107109371A CN 201580063072 A CN201580063072 A CN 201580063072A CN 107109371 A CN107109371 A CN 107109371A
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protein
virus
genome segment
coding region
rp18tri
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Chinese (zh)
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H.李
Y.梁
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UNVIVERSITY OF MINNESOTA
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UNVIVERSITY OF MINNESOTA
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2760/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201580063072.3A 2014-09-22 2015-09-22 皮钦德病毒反向遗传学系统及其使用方法 Pending CN107109371A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053443P 2014-09-22 2014-09-22
US62/053443 2014-09-22
PCT/US2015/051337 WO2016048949A1 (en) 2014-09-22 2015-09-22 Pichinde virus reverse genetics system and methods of use

Publications (1)

Publication Number Publication Date
CN107109371A true CN107109371A (zh) 2017-08-29

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CN201580063072.3A Pending CN107109371A (zh) 2014-09-22 2015-09-22 皮钦德病毒反向遗传学系统及其使用方法

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Country Link
US (2) US10533159B2 (https=)
EP (1) EP3198008B1 (https=)
JP (1) JP6875274B6 (https=)
KR (1) KR20170057384A (https=)
CN (1) CN107109371A (https=)
AU (1) AU2015321557B2 (https=)
BR (1) BR112017005744B1 (https=)
CA (1) CA2961913A1 (https=)
ES (1) ES2746150T3 (https=)
MX (1) MX391006B (https=)
PL (1) PL3198008T3 (https=)
WO (1) WO2016048949A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107109371A (zh) 2014-09-22 2017-08-29 明尼苏达大学评议会 皮钦德病毒反向遗传学系统及其使用方法
SI3218504T1 (sl) * 2014-11-13 2020-11-30 Universite De Geneve Tri-segmentirani arenavirusi kot vakcinski vektorji
AU2016274655B2 (en) 2015-06-10 2021-06-17 NeoTrail Therapeutics, Inc. HPV vaccines
CA3003557A1 (en) 2015-11-04 2017-05-11 Hookipa Biotech Ag Vaccines against hepatitis b virus
DK3373959T3 (da) 2015-11-12 2022-09-19 Hookipa Biotech Gmbh Arenaviruspartikler som cancervacciner
IL262963B2 (en) * 2016-05-18 2025-01-01 Hookipa Biotech Gmbh Trisegmented PICHINDE viruses as vaccine vectors
US20230310574A1 (en) * 2020-08-06 2023-10-05 Regents Of The University Of Minnesota Multivalent vaccines against turkey arthritis reovirus
WO2022269362A2 (en) 2021-06-21 2022-12-29 Vaxxinova International B.V. Veterinary viral vector
WO2024155646A1 (en) * 2023-01-17 2024-07-25 Regents Of The University Of Minnesota Multivalent vaccines against tuberculosis

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101801189A (zh) * 2007-08-27 2010-08-11 西佳技术公司 用于治疗沙粒病毒感染的抗病毒药
CN101918565A (zh) * 2007-12-27 2010-12-15 苏黎士大学 复制缺陷型沙粒病毒载体

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ES2170622B1 (es) 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
AP3126A (en) 2007-12-21 2015-02-28 Government Of The Us Secretary Recombinant rift valley fever (RVF) viruses and methods of use
EP2478103A4 (en) 2009-09-16 2014-02-19 Univ Tulane LASSAVIRUS-like PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
GB201007790D0 (en) 2010-05-10 2010-06-23 Isis Innovation Compositions
JP2013531496A (ja) 2010-06-06 2013-08-08 モウント シナイ スクール オフ メディシネ 組換えｒｎａウイルス及びその使用
CN107109371A (zh) 2014-09-22 2017-08-29 明尼苏达大学评议会 皮钦德病毒反向遗传学系统及其使用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801189A (zh) * 2007-08-27 2010-08-11 西佳技术公司 用于治疗沙粒病毒感染的抗病毒药
CN101918565A (zh) * 2007-12-27 2010-12-15 苏黎士大学 复制缺陷型沙粒病毒载体

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DANIEL L.POPKIN等: "Expanded Potential for Recombinant Trisegmented Lymphocytic Choriomeningitis Viruses: Protein Production, Antibody Production, and in Vivo Assessment of Biological Function of Genes of Interest", 《JOURNAL OF VIROLOGY》 *
EMONET, SF等: "Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA》 *
LAN，S.等: "Pichinde virus strain Munchique CoAn4763 isolate P2 segment S", 《NCBI》 *
QI，XX等: "Cap binding and immune evasion revealed by Lassa nucleoprotein structure", 《NATURE》 *
SHUIYUN LAN等: "Development of Infectious Clones for Virulent and Avirulent Pichinde Viruses: A Model Virus to Study Arenavirus-Induced Hemorrhagic Fevers", 《JOURNAL OF VIROLOGY》 *

Also Published As

Publication number Publication date
KR20170057384A (ko) 2017-05-24
PL3198008T3 (pl) 2020-03-31
EP3198008B1 (en) 2019-05-29
ES2746150T3 (es) 2020-03-04
WO2016048949A1 (en) 2016-03-31
BR112017005744B1 (pt) 2023-11-28
US11993789B2 (en) 2024-05-28
BR112017005744A2 (pt) 2017-12-12
US20200165578A1 (en) 2020-05-28
AU2015321557B2 (en) 2020-05-14
US20170292119A1 (en) 2017-10-12
AU2015321557A1 (en) 2017-04-06
MX391006B (es) 2025-03-21
JP6875274B2 (ja) 2021-05-19
EP3198008A1 (en) 2017-08-02
CA2961913A1 (en) 2016-03-31
JP2017529084A (ja) 2017-10-05
US10533159B2 (en) 2020-01-14
MX2017003694A (es) 2017-10-12
JP6875274B6 (ja) 2021-06-30

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