CN107106678A - 用于治疗患有高胆固醇血症的高心血管风险患者的方法 - Google Patents

用于治疗患有高胆固醇血症的高心血管风险患者的方法 Download PDF

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Publication number
CN107106678A
CN107106678A CN201580049703.6A CN201580049703A CN107106678A CN 107106678 A CN107106678 A CN 107106678A CN 201580049703 A CN201580049703 A CN 201580049703A CN 107106678 A CN107106678 A CN 107106678A
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patient
antibody
patients
dose
ldl
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Pending
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CN201580049703.6A
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English (en)
Chinese (zh)
Inventor
C·阿诺汀
L·贝萨克
U·乔杜里
R·波尔迪
D·A·施韦默尔吉普
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Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
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Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
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Priority to CN202111397525.XA priority Critical patent/CN114306592A/zh
Publication of CN107106678A publication Critical patent/CN107106678A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580049703.6A 2014-07-16 2015-07-16 用于治疗患有高胆固醇血症的高心血管风险患者的方法 Pending CN107106678A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111397525.XA CN114306592A (zh) 2014-07-16 2015-07-16 用于治疗患有高胆固醇血症的高心血管风险患者的方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462025371P 2014-07-16 2014-07-16
US62/025,371 2014-07-16
US201462043167P 2014-08-28 2014-08-28
US62/043,167 2014-08-28
US201462080725P 2014-11-17 2014-11-17
US62/080,725 2014-11-17
US201562132709P 2015-03-13 2015-03-13
US62/132,709 2015-03-13
EP15305830 2015-05-29
EP15305830.0 2015-05-29
PCT/US2015/040765 WO2016011260A1 (en) 2014-07-16 2015-07-16 Methods for treating high cardiovascular risk patients with hypercholesterolemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202111397525.XA Division CN114306592A (zh) 2014-07-16 2015-07-16 用于治疗患有高胆固醇血症的高心血管风险患者的方法

Publications (1)

Publication Number Publication Date
CN107106678A true CN107106678A (zh) 2017-08-29

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CN202111397525.XA Pending CN114306592A (zh) 2014-07-16 2015-07-16 用于治疗患有高胆固醇血症的高心血管风险患者的方法
CN201580049703.6A Pending CN107106678A (zh) 2014-07-16 2015-07-16 用于治疗患有高胆固醇血症的高心血管风险患者的方法

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Country Status (12)

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US (2) US20160137746A1 (enExample)
EP (2) EP3753575A1 (enExample)
JP (1) JP6912374B2 (enExample)
KR (3) KR20240132123A (enExample)
CN (2) CN114306592A (enExample)
AU (1) AU2015289617B2 (enExample)
CA (1) CA2955304C (enExample)
MX (2) MX378872B (enExample)
PL (1) PL3169362T3 (enExample)
RU (1) RU2723018C2 (enExample)
WO (1) WO2016011260A1 (enExample)
ZA (1) ZA201700196B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021098720A1 (zh) * 2019-11-18 2021-05-27 康融东方（广东）医药有限公司 抗pcsk9抗体及其应用
CN113015543A (zh) * 2018-03-06 2021-06-22 赛诺菲生物技术公司 Pcsk9抑制剂用于降低心血管风险的用途
CN116096365A (zh) * 2020-08-07 2023-05-09 瑞泽恩制药公司 涉及angptl3抑制剂的治疗难治性高胆固醇血症的方法
WO2025067337A1 (zh) * 2023-09-28 2025-04-03 康霖生物科技（杭州）有限公司 用于基因治疗的核酸构建体及其用途
US12281173B2 (en) 2016-03-03 2025-04-22 Regeneron Pharmaceuticals, Inc. Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor

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US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
MX347602B (es) 2011-01-28 2017-05-03 Sanofi Biotechnology Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9.
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
PL4252857T3 (pl) 2011-09-16 2025-03-03 Regeneron Pharmaceuticals, Inc. Sposoby redukowania poziomów lipoproteiny(a) poprzez podawanie inhibitora proproteinowej konwertazy subtylizyny keksyny-9 (pcsk9)
US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
CA2914721A1 (en) 2013-06-07 2014-12-11 Regeneron Pharmaceuticals, Inc. Methods for inhibiting atherosclerosis by administering an inhibitor of pcsk9
JP6616298B2 (ja) 2013-11-12 2019-12-04 サノフィ・バイオテクノロジー Ｐｃｓｋ９阻害剤と共に使用するための投薬レジメン
CA2955294A1 (en) 2014-07-16 2016-01-21 Sanofi Biotechnology Methods for treating patients with heterozygous familial hypercholesterolemia (hefh)
EP3197492A1 (en) * 2014-09-23 2017-08-02 Pfizer Inc Treatment with anti-pcsk9 antibodies
US10772956B2 (en) 2015-08-18 2020-09-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab
TW201904608A (zh) * 2017-06-09 2019-02-01 法商賽諾菲生物技術公司 藉由投予ｐｃｓｋ９抑制劑治療糖尿病患者高血脂症之方法

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CN102245641A (zh) * 2008-12-15 2011-11-16 瑞泽恩制药公司 抗pcsk9的高亲和力人抗体
EP2706070A1 (en) * 2012-09-06 2014-03-12 Sanofi Combination treatments involving antibodies to human PCSK9
CN103841992A (zh) * 2011-05-10 2014-06-04 安姆根有限公司 治疗或预防胆固醇相关疾病的方法

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US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
MX347602B (es) * 2011-01-28 2017-05-03 Sanofi Biotechnology Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9.
US20130006482A1 (en) * 2011-06-30 2013-01-03 Ramadev Burigsay Hukkeri Guidance system for a mobile machine
PL4252857T3 (pl) * 2011-09-16 2025-03-03 Regeneron Pharmaceuticals, Inc. Sposoby redukowania poziomów lipoproteiny(a) poprzez podawanie inhibitora proproteinowej konwertazy subtylizyny keksyny-9 (pcsk9)
EA039310B1 (ru) * 2015-02-26 2022-01-12 Санофи Байотекнолоджи Способы снижения сердечно-сосудистого риска

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CN103841992A (zh) * 2011-05-10 2014-06-04 安姆根有限公司 治疗或预防胆固醇相关疾病的方法
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FREDERICK RAAL 等: "Low-density Lipoprotein Cholesterol-Lowering Effects of AMG 145, a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients With Heterozygous Familial Hypercholesterolemia: The Reduction of LDL-C With PCSK9 Inhibitio", 《CIRCULATION》 *
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12281173B2 (en) 2016-03-03 2025-04-22 Regeneron Pharmaceuticals, Inc. Methods for treating patients with hyperlipidemia by administering a PCSK9 inhibitor in combination with an ANGPTL3 inhibitor
CN113015543A (zh) * 2018-03-06 2021-06-22 赛诺菲生物技术公司 Pcsk9抑制剂用于降低心血管风险的用途
WO2021098720A1 (zh) * 2019-11-18 2021-05-27 康融东方（广东）医药有限公司 抗pcsk9抗体及其应用
CN116096365A (zh) * 2020-08-07 2023-05-09 瑞泽恩制药公司 涉及angptl3抑制剂的治疗难治性高胆固醇血症的方法
WO2025067337A1 (zh) * 2023-09-28 2025-04-03 康霖生物科技（杭州）有限公司 用于基因治疗的核酸构建体及其用途

Also Published As

Publication number Publication date
MX2021000289A (es) 2021-03-31
KR20170028441A (ko) 2017-03-13
KR20240132123A (ko) 2024-09-02
EP3169362B1 (en) 2020-06-10
WO2016011260A1 (en) 2016-01-21
US20160137746A1 (en) 2016-05-19
EP3753575A1 (en) 2020-12-23
RU2017104799A (ru) 2018-08-16
US20200255544A1 (en) 2020-08-13
AU2015289617B2 (en) 2021-04-15
MX378872B (es) 2025-03-11
ZA201700196B (en) 2024-09-25
KR102482375B1 (ko) 2022-12-29
PL3169362T3 (pl) 2020-12-28
RU2017104799A3 (enExample) 2019-02-19
RU2723018C2 (ru) 2020-06-08
CN114306592A (zh) 2022-04-12
CA2955304C (en) 2023-12-12
JP6912374B2 (ja) 2021-08-04
MX2017000628A (es) 2017-04-27
JP2017522316A (ja) 2017-08-10
CA2955304A1 (en) 2016-01-21
KR20230007538A (ko) 2023-01-12
AU2015289617A1 (en) 2017-02-02
EP3169362A1 (en) 2017-05-24

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