CN107081121B - A kind of multi-functional continuous flow reaction system - Google Patents
A kind of multi-functional continuous flow reaction system Download PDFInfo
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- CN107081121B CN107081121B CN201710434482.5A CN201710434482A CN107081121B CN 107081121 B CN107081121 B CN 107081121B CN 201710434482 A CN201710434482 A CN 201710434482A CN 107081121 B CN107081121 B CN 107081121B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/245—Stationary reactors without moving elements inside placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/14—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects using gases or vapours other than air or steam, e.g. inert gases
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to chemical pharmaceutical technical fields, more particularly to a kind of multi-functional continuous flow reaction system, including multistage feeding equipment, multistage mixing arrangement, multistage preheating device, multi-stage reacting device, device is quenched, CIP cleaning devices and blow drying device, reaction tube in reaction unit is sequentially communicated by communication apparatus, each material concentration needed according to chemical reaction is with when corresponding reaction condition, by software and general hardware platform to the feeding equipment, mixing arrangement, preheating device, reaction unit, device is quenched, CIP cleaning devices and blow drying device are controlled.The multi-functional continuous flow reaction system of the present invention, good mixing effect, reaction condition control is accurate, heat transfer is uniformly mixed, volume and space are smaller, and production cost is low, can continuously realize that multi-grade chemical reacts, and can efficiently understand that the reactant in reaction system remains, keep the inside of reaction system clean.
Description
Technical field
The present invention relates to chemical pharmaceutical technical fields, and in particular to a kind of continuous flow reaction system.
Background technology
The common reactor apparatus of chemical pharmaceutical technical field includes tubular reactor and tank reactor etc., wherein autoclave
Reactor is often packed into agitating device in a kettle, for liquid phase reactor object mix, synthetic purity, reaction conversion ratio compared with
Low, energy consumption and pollution are more serious.Since field of chemical pharmacy is more demanding to the purity of product etc., the reaction being often used
Device equipment is continuous flow tubular reactor.
Chemical reactant concentration in tubular reactor changes with reaction rate with pipe range, therefore tubular reactor needs completely
Foot chemically reacts the limit of required pipe range, existing straight tube reactor or U-tube reactor due to bending part production technology
System, will accomplish longer pipe range, then the volume of reactor is larger.In addition, existing tubular reactor has a single function, and can not be very
Good completion chemically reacts required reaction condition, be sufficiently mixed such as mass transfer, heat transfer are required, accurate temperature controlling, it is enough
Tube length of reaction tube and the corresponding data of on-line checking etc..
Invention content
The present invention proposes a kind of multi-functional continuous flow reaction system, to solve existing tubular reactor system floor space
Greatly, mass transfer, heat transfer mixing are not uniform enough, can not accomplish that accurate temperature controlling and on-line monitoring, cleaning and drying are quenched and repeatedly mix
Etc. technical problems.
The multi-functional continuous flow reaction system of the present invention, including multistage feeding equipment, multistage mixing arrangement, multistage pre- hot charging
It sets, multi-stage reacting device, device, CIP cleaning devices and blow drying device be quenched;
Every grade of feeding equipment, mixing arrangement, preheating device, reaction unit are sequentially communicated, first order mixing arrangement with
The CIP cleaning devices, blow drying device are connected, and are connected with rear stage mixing arrangement per order reaction device, last
The reaction unit of grade is connected with the device that is quenched;
Every grade of feeding equipment includes one or more groups of sequentially connected head tanks, feed pump and flow controller, institute
Each head tank is stated for containing a kind of reaction solution, the flow controller is for controlling the feed pump from the head tank
In with given pace abstraction reaction solution;
Every grade of mixing arrangement obtains mixing molten for mixing the reaction solution extracted from the head tank
Liquid;
Every grade of preheating device includes preheating tube side and preheating shell side, and the preheating tube side is for circulating from the mixing
The mixed solution that device imports, the pre- thermal medium that the preheating shell side is used to circulate for preheating reactant are pre- by mixed solution
Heat is to reactivity critical-temperature;
Every grade of reaction unit includes reactor shell, and the lower part of the reactor shell is provided with shell side inlet, instead
The top of device shell is answered to be provided with shell-side outlet, the heating for being used to circulate for heating reactant inside the shell side of reactor shell
Medium;The upper and lower ends of reactor shell are respectively connected with tube sheet and communication apparatus, and reactor shell is internally provided with for flowing
The reaction tube group of logical reactant, the reaction tube group includes more reaction tubes, and the upper and lower ends of every reaction tube are passed through and fixed
It is connected on the tube sheet, all reaction tubes are sequentially communicated by the communication apparatus.
Preferably, it is provided with reactant entrance and reactant exit on the communication apparatus of the reactor shell lower end,
The reactant entrance is connected to the preheating device, and the reactant exit is connected to rear stage mixing arrangement or device is quenched.
Preferably, being provided with temperature instrument, pressure detecting instrument on the communication apparatus of the reactor shell upper end
Table and detector for pH value table, for measuring the temperature in the reaction tube, pressure and soda acid degrees of data.
Preferably, the communication apparatus uses baffling bobbin carriage, it is provided on the baffling bobbin carriage and multiple is reacted with described
The adjacent corresponding baffling slot of two reaction tubes in pipe communication direction, all reaction tubes by the baffling slot on baffling bobbin carriage successively
Connection.
It is arranged preferably, the more reaction tubes are wound with certain helix angle.
Preferably, the CIP cleaning devices include multiple Materials Solvents cleaning devices, the mixing is cleaned for replacing
Device, preheating device, the different material solution residual in reaction unit.
Preferably, the blow drying device includes inert gas generator and gas preheater, for generating hot wind,
The mixing arrangement, preheating device, reaction unit are dried.
Preferably, reaction unit described in afterbody and described be quenched between device are provided with humidity measurement instrument, it is used for
Gas humidity after starting to the blow drying device is detected.
The multi-functional continuous flow reaction system of the present invention when in use, is matched according to each material concentration that chemical reaction needs
And corresponding reaction condition, by software and general hardware platform to the feeding equipment, mixing arrangement, preheating device, anti-
Device is answered, device, CIP cleaning devices and blow drying device is quenched is controlled.Material solution feeds from the first order fill first
It sets and enters first order mixing arrangement according to determining flow proportional;After mixing completely, mixed solution enters preheating device, and preheats
To reactivity critical-temperature;The mixed solution that preheating is completed subsequently enters first order reaction unit, in preset temperature, pressure
It is fully chemically reacted under the conditions of power, acid-base value, obtains first order product;First order product and second level material solution are common
It is mixed, is repeated the above steps into second level mixing arrangement, until obtaining final product;Final product, which enters, is quenched dress
It sets, obtains final product after cooling;After reaction, software and the control CIP cleaning devices output of general hardware platform are former
Expect liquid cleaning solvent, the different material solution in mixing arrangement, preheating device, reaction unit is remained into line replacement and is cleaned, clearly
After washing, restart blow drying device, mixing arrangement, preheating device, reaction unit are dried, residual liquid is prevented
Influence the progress chemically reacted next time.
The multi-functional continuous flow reaction system of the present invention, has the following advantages that:
(1) by the way that mixing arrangement is arranged, so that a variety of reaction solutions is sufficiently mixed, improve reaction efficiency.
(2) by the way that preheating device is arranged, mixed reaction solution is made to heat up in advance before entering the reactor, into reaction
Reach reaction temperature after device as early as possible, improves reaction efficiency.
(3) reaction unit uses continuous flow pipeline, continuous flow pipeline to be connected to by baffling bobbin carriage, substantially reduces adjacent anti-
The distance between should manage, so that the length of unit volume reaction tubes is increased significantly, under conditions of meeting same chemical reaction, this
The volume and space smaller, production cost of invention are lower.
(4) reaction tube is wound in the shape of a spiral, and reactant makes reactant low along the spiral tangential motion of helically coiled
High reynolds number is obtained under flow condition, greatly improves turbulence effects, remains to uninterruptedly mix in continuous flowing reactive;In addition,
Wound form reaction tube group is integrally in spring form, can pass thermogenetic thermal stress with elimination reaction, will not conduct thermal stress to pipe
Plate end substantially increases the service life of equipment.
(5) CIP cleaning devices and blow drying device can efficiently in removing system upper secondary response reflection solution residual,
It keeps the inside of reaction system clean, avoids the progress for influencing the lower secondary response of reaction system.
(6) multistage feeding equipment, mixing arrangement, preheating device and reaction unit, are connected by continuous flow pipeline, are applicable in
In the lasting progress of reaction of high order, the step of reducing repetition material stock, feed, and the waste heat that upper level can be made full use of to react,
Production efficiency is improved, production cost is reduced.
Description of the drawings
Fig. 1 is the overall structure diagram of the multi-functional continuous flow reaction system of the present invention;
Fig. 2 is the structural schematic diagram of the reaction unit of the multi-functional continuous flow reaction system of the present invention;
Fig. 3 is the baffling bobbin carriage horizontal cross-section structure diagram of the multi-functional continuous flow reaction system of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1:
As shown in Figs. 1-2, the multi-functional continuous flow reaction system of the present embodiment, including the mixing of level-one feeding equipment 1, level-one
Device 2, level-one preheating device 3, first order reaction device 4, two level feeding equipment 10, two level mixing arrangement 20, two level preheating device
30, second order reaction device 40, device 5, CIP cleaning devices 6 and blow drying device 7 is quenched;
The level-one feeding equipment 1, level-one mixing arrangement 2, level-one preheating device 3, first order reaction device 4 are sequentially communicated,
The two level feeding equipment 10, two level mixing arrangement 20, two level preheating device 30, second order reaction device 40 are sequentially communicated, described
CIP cleaning devices 6, blow drying device 7 are connected with the level-one mixing arrangement 2, and the first order reaction device 4 is mixed with two level
It attaches together and sets 20 and be connected, the second order reaction device 40 is connected with the device 5 that is quenched;
Level-one feeding equipment 1, two level feeding equipment 10 include one or more groups of sequentially connected head tanks 100, charging
Pump 101 and flow controller 102, each head tank 100 is for containing a kind of reaction solution, the flow controller 102
For controlling the feed pump 101 from the head tank 100 with given pace abstraction reaction solution;
Level-one mixing arrangement 2, two level mixing arrangement 20 are used to carry out the reaction solution extracted from the head tank 100
Mixing, obtains mixed solution;
Level-one preheating device 3, two level preheating device 30 include preheating tube side 300 and preheating shell side 301, preheat tube side
300 for the mixed solution imported from the level-one mixing arrangement 2, two level mixing arrangement 20 that circulates, and preheating shell side 301 is for flowing
It is common to the pre- thermal medium of preheating reactant, mixed solution is preheated to reactivity critical-temperature;
First order reaction device 4, second order reaction device 40 include reactor shell 400, and the lower part of reactor shell 400 is set
It is equipped with shell side inlet 401, top is provided with shell-side outlet 402, is used to circulate for heating inside the shell side of reactor shell 400
The heat medium of reactant;The upper and lower ends of reactor shell 400 are respectively connected with tube sheet 403 and communication apparatus, reactor shell
400 inside is additionally provided with the reaction tube group for the reactant that circulates, and the reaction tube group includes more reaction tubes 404, every
The upper and lower ends of reaction tube 404 are passed through and are fixedly connected on the tube sheet 403, and all reaction tubes 404 are filled by the connection
It sets and is sequentially communicated.
Further, it is provided with reactant entrance 405 on the communication apparatus of 400 lower end of reactor shell in the present embodiment
With reactant exit 406, reactant entrance 405 is connected to preheating device, the connection of reactant exit 406 two of first order reaction device 4
Device 5 is quenched in the connection of reactant exit 406 of grade mixing arrangement 20, second order reaction device 40.
Further, it is provided with temperature instrument on the communication apparatus of 400 upper end of reactor shell in the present embodiment
407, pressure instrumentation 408 and detector for pH value table 409, for measuring temperature, pressure and acid in the reaction tube 404
Basicity data.
Further, the communication apparatus in the present embodiment uses baffling bobbin carriage 410, is provided on baffling bobbin carriage 410 multiple
Baffling slot 411 corresponding with adjacent two reaction tubes 404 in 404 communication direction of the reaction tube, all reaction tubes 404 pass through
Baffling slot 411 on baffling bobbin carriage 410 is sequentially communicated.It is connected to adjacent reaction tube 404 using baffling slot 411, overcomes existing
The limitation of technology bending part production technology, can greatly reduce the distance between adjacent reaction pipe 404, make reaction in unit volume
The length of pipe increases significantly, under conditions of meeting same chemical reaction, the volume of the reaction unit in the present embodiment and occupation of land
Space smaller.
Further, mostly being wound with certain helix angle with reaction tube 404 in the present embodiment is arranged, and it is anti-to form wound form
Should pipe group, wound form reaction tube group winds in the shape of a spiral, and reactant makes reactant along the spiral tangential motion of helically coiled
High reynolds number is obtained in low flow velocity, greatly improves turbulence effects, remains to uninterruptedly mix in continuous flowing reactive;Separately
Outside, wound form reaction tube group is integrally in spring form, can pass thermogenetic thermal stress with elimination reaction, thermal stress will not be conducted to
Tube sheet end substantially increases the service life of equipment.
Further, the CIP cleaning devices 6 in the present embodiment include multiple Materials Solvents cleaning devices 60, for replacing
Clean mixing arrangement, preheating device, the different material solution residual in reaction unit.
Further, the blow drying device 7 in the present embodiment includes inert gas generator and gas preheater, is used for
Hot wind is generated, mixing arrangement, preheating device, reaction unit are dried.
Further, it the second order reaction device 40 in the present embodiment and is quenched between device 5 and is provided with humidity measurement instrument 8,
It is detected for the gas humidity after starting to blow drying device.
The multi-functional continuous flow reaction system of the present embodiment when in use, match by a material concentration needed according to chemical reaction
When corresponding reaction condition, by software and general hardware platform to the feeding equipment, mixing arrangement, preheating device,
Reaction unit is quenched device 5, CIP cleaning devices 6 and blow drying device 7 and is controlled.Material solution is fed from level-one first
Device 1 enters level-one mixing arrangement 2 according to determining flow proportional;After mixing completely, mixed solution enters level-one preheating device
3, and it is preheated to reactivity critical-temperature;The mixed solution that preheating is completed subsequently enters first order reaction device 4, in preset temperature
It is fully chemically reacted under the conditions of degree, pressure, acid-base value, obtains primary product;Primary product and secondary raw materials solution are common
It is mixed, is repeated the above steps into two level mixing arrangement 20, until obtaining final product;Final product, which enters, is quenched device
5, obtain final product after cooling;After reaction, software and general hardware platform control CIP cleaning devices 6 export original
Expect liquid cleaning solvent, the different material solution in mixing arrangement, preheating device, reaction unit is remained into line replacement and is cleaned, clearly
After washing, restart blow drying device 7, mixing arrangement, preheating device, reaction unit are dried, Liquid Residue is prevented
Body influences the progress chemically reacted next time.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, it is noted that for this
For the those of ordinary skill of technical field, under the premise of not departing from the application principle, several improvement and profit can also be made
Decorations, all within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on are regarded as being included in this
Within the protection domain of invention.
Claims (6)
1. a kind of multi-functional continuous flow reaction system, it is characterised in that:Including multistage feeding equipment, multistage mixing arrangement, multistage
Device, CIP cleaning devices and blow drying device is quenched in preheating device, multi-stage reacting device;
Every grade of feeding equipment, mixing arrangement, preheating device, reaction unit are sequentially communicated, first order mixing arrangement with it is described
CIP cleaning devices, blow drying device are connected, and are connected with rear stage mixing arrangement per order reaction device, afterbody
Reaction unit is connected with the device that is quenched;
Every grade of feeding equipment includes one or more groups of sequentially connected head tanks, feed pump and flow controller, described every
A head tank for containing a kind of reaction solution, the flow controller for control the feed pump from the head tank with
Given pace abstraction reaction solution;
Every grade of mixing arrangement obtains mixed solution for mixing the reaction solution extracted from the head tank;
Every grade of preheating device includes preheating tube side and preheating shell side, and the preheating tube side is for circulating from the mixing arrangement
The mixed solution of importing, the pre- thermal medium that the preheating shell side is used to circulate for preheating reactant, mixed solution is preheated to
Reactivity critical-temperature;
Every grade of reaction unit includes reactor shell, and the lower part of the reactor shell is provided with shell side inlet, reactor
The top of shell is provided with shell-side outlet, is situated between for heating the heating of reactant for circulating inside the shell side of reactor shell
Matter;The upper and lower ends of reactor shell are respectively connected with tube sheet and communication apparatus, and reactor shell is internally provided with for circulating
The reaction tube group of reactant, the reaction tube group include more reaction tubes, and the upper and lower ends of every reaction tube pass through and the company of fixation
It is connected on the tube sheet, all reaction tubes are sequentially communicated by the communication apparatus, and the communication apparatus uses baffling bobbin carriage, institute
It states and is provided with multiple baffling slots corresponding with adjacent two reaction tubes in the reaction tube communication direction on baffling bobbin carriage, own
Reaction tube is sequentially communicated by the baffling slot on baffling bobbin carriage, and temperature is provided on the communication apparatus of the reactor shell upper end
Instrument, pressure instrumentation and detector for pH value table are detected, for measuring temperature, pressure and acid-base value in the reaction tube
Data.
2. a kind of multi-functional continuous flow reaction system as described in claim 1, it is characterised in that:The reactor shell lower end
Communication apparatus on be provided with reactant entrance and reactant exit, the reactant entrance is connected to the preheating device, described
Reactant exit is connected to rear stage mixing arrangement or device is quenched.
3. a kind of multi-functional continuous flow reaction system as claimed in claim 1 or 2, it is characterised in that:The more reaction tubes
It is wound and is arranged with certain helix angle.
4. a kind of multi-functional continuous flow reaction system as described in claim 1, it is characterised in that:The CIP cleaning devices packet
Multiple Materials Solvents cleaning devices are included, for replace the cleaning mixing arrangement, preheating device, the different material in reaction unit
Solution remains.
5. a kind of multi-functional continuous flow reaction system as described in claim 1, it is characterised in that:The blow drying device packet
Include inert gas generator and gas preheater, for generating hot wind, to the mixing arrangement, preheating device, reaction unit into
Row drying.
6. a kind of multi-functional continuous flow reaction system as described in claim 1, it is characterised in that:Dress is reacted described in afterbody
Set and described be quenched between device be provided with humidity measurement instrument, for the blow drying device start after gas humidity into
Row detection.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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CN201710434482.5A CN107081121B (en) | 2017-06-09 | 2017-06-09 | A kind of multi-functional continuous flow reaction system |
PCT/CN2018/088680 WO2018223862A1 (en) | 2017-06-09 | 2018-05-28 | Baffling tube box, continuous flow reactor, continuous flow reaction system and control system |
US16/616,447 US10807065B2 (en) | 2017-06-09 | 2018-05-28 | Baffling tube box, continuous flow reactor, continuous flow reaction system and control system |
RU2019142135A RU2726178C1 (en) | 2017-06-09 | 2018-05-28 | Pipe flow deflection chamber, continuous flow reactor and continuous flow reaction system with control system |
EP18813078.5A EP3616785B1 (en) | 2017-06-09 | 2018-05-28 | Baffling tube box, continuous flow reactor, continuous flow reaction system and control system |
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CN201710434482.5A CN107081121B (en) | 2017-06-09 | 2017-06-09 | A kind of multi-functional continuous flow reaction system |
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CN107081121A CN107081121A (en) | 2017-08-22 |
CN107081121B true CN107081121B (en) | 2018-07-27 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3616785B1 (en) | 2017-06-09 | 2022-01-12 | Shandong Nuowei Pharmaceutical Fluid System Co., Ltd | Baffling tube box, continuous flow reactor, continuous flow reaction system and control system |
CN108129267B (en) * | 2018-01-11 | 2024-04-19 | 吉林凯莱英医药化学有限公司 | Low-temperature full-continuous reaction system and application |
CN109277054B (en) * | 2018-11-15 | 2023-09-12 | 山东诺为制药流体系统有限公司 | Accurate feeding continuous flow reaction system capable of quenching |
CN111250027B (en) * | 2020-03-05 | 2022-03-11 | 内蒙古兰格生物科技有限公司 | Drug intermediate reaction tube and production line |
CN116441259B (en) * | 2022-06-16 | 2023-11-24 | 华大工程生物学长荡湖研究所 | Method for cleaning common equipment of continuous flow system |
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JP6024299B2 (en) * | 2012-02-14 | 2016-11-16 | 株式会社リコー | Polymer production method and polymer continuous production apparatus |
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CN104258796A (en) * | 2014-10-13 | 2015-01-07 | 南京工业大学 | Novel high-flux multilayer spiral winding pipe micro-channel reactor |
CN105061646A (en) * | 2015-05-06 | 2015-11-18 | 爱森(中国)絮凝剂有限公司 | Polyacrylamide production line |
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Address after: 276100 No.1 Nuowei Road, Tancheng high tech electronic industrial park, Linyi City, Shandong Province Patentee after: SHANDONG NERVE PHARMACEUTICAL FLUID SYSTEM Co.,Ltd. Address before: 276000 3rd floor, block B, science and Technology Pioneer Park, shuangyueyuan Road, high tech Zone, Linyi City, Shandong Province Patentee before: SHANDONG NERVE PHARMACEUTICAL FLUID SYSTEM Co.,Ltd. |
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CP02 | Change in the address of a patent holder |