CN107050178A - A kind of Chinese medicine for treating cervical carcinoma - Google Patents
A kind of Chinese medicine for treating cervical carcinoma Download PDFInfo
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- CN107050178A CN107050178A CN201710113507.1A CN201710113507A CN107050178A CN 107050178 A CN107050178 A CN 107050178A CN 201710113507 A CN201710113507 A CN 201710113507A CN 107050178 A CN107050178 A CN 107050178A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to the Chinese medicine for the treatment of cervical carcinoma, it is good effectively to solve clinical treatment cervical carcinoma effect, the problem of cervical cancer patient death rate is high, and its technical scheme solved is that the Chinese medicine is made up of the material medicine of following parts by weight meter：17 20 parts of Patrinia heterophylla, another name for Sichuan Province sheep weigh 17 20 parts, 7 10 parts of 7 10 parts of frutus cnidii and bark of tree of heaven, and pure Chinese medicinal preparation of the present invention, abundant raw material, prescription is small, and expense is low, determined curative effect, safe and convenient, meets traditional Chinese medicine prescription theory, are the innovations on the medicine for treat cervical carcinoma.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for treating cervical carcinoma.
Background technology
Cervical carcinoma is one of most common female reproductive system malignant tumour in world wide, and it is new that the annual whole world there are about 520,000
Morbidity example, causes nearly 70,000 people dead, seriously threatens women's health.Now it has proven convenient that continuation high-risk human mammilla papillomavirus infects
It is to cause the main cause and necessary condition of cervical carcinoma.For cervical carcinoma caused by HPV infection, though treatment method is varied,
Radiotherapy chemotherapy, operation are shared, or Chinese medicine is used alone, synergy, attenuation is played, improves a variety of effects such as life quality, extension life cycle
Should.Further study show that, part Chinese medicine can prevent and treat carcinogenic chemicals, suppression growth of tumour cell, promote tumour cell to wither
Die, improve immunity of organisms etc..See that Radix Angelicae Sinensis belongs to the models such as " Disorder lumps in the abdomen ", " uterine bleeding ", " mutil-colorea leukorrhea " according to cervix cancer clinical manifestation
Farmland, many Coryza Treated by Syndrome Differentiation of Chinese medicine lack the new Chinese medicine for being exclusively used in treating cervical carcinoma, therefore, booster injection is in cervical carcinoma
Medicine is researched and developed, and for improving clinical prevention level and ability, reduces the cervical cancer patient death rate significant.
The content of the invention
For above-mentioned situation, to solve the defect of prior art, the purpose of the present invention is just to provide one kind and treats cervical carcinoma
Chinese medicine, it is good effectively to solve clinical treatment cervical carcinoma effect, the problem of cervical cancer patient death rate is high.
The technical scheme that the present invention is solved is that the Chinese medicine is made up of the material medicine of following parts by weight meter：Patrinia heterophylla
7-10 parts of 17-20 parts, 17-20 parts of another name for Sichuan Province sheep power, 7-10 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, raw material is added
The water of 15 times of weight of medicine, immersion 30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with first
The absolute ethyl alcohol alcohol precipitation 8-12h of 1.5 times of weight of filtrate, filtering, obtains the second filtrate, and the second filtrate is under 1500r/min, centrifugation
10min, takes supernatant, vacuum drying, produces.
Pure Chinese medicinal preparation of the present invention, abundant raw material, prescription is small, and expense is low, determined curative effect, and safe and convenient meets traditional Chinese medicine
Prescription theory, is the innovation on the medicine for treat cervical carcinoma.
Brief description of the drawings
Fig. 1 is inhibitory action time-effect relationship (%) figure that Chinese medicine of the present invention grows to s.
Embodiment
The embodiment to the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following parts by weight meter：17 parts of Patrinia heterophylla, another name for Sichuan Province sheep power
7 parts of 17 parts, 7 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, and adds the water of 15 times of weight of material medicine, immersion
30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with the anhydrous second of 1.5 times of weight of the first filtrate
Alcohol alcohol precipitation 8h, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min, take supernatant under 1500r/min, is dried in vacuo, i.e.,
.
Embodiment 2
The present invention in the specific implementation, can also be made up of the material medicine of following parts by weight meter：18 parts of Patrinia heterophylla, another name for Sichuan Province sheep
8 parts of 18 parts of power, 8 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, and adds the water of 15 times of weight of material medicine, immersion
30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with the anhydrous second of 1.5 times of weight of the first filtrate
Alcohol alcohol precipitation 9h, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min, take supernatant under 1500r/min, is dried in vacuo, i.e.,
.
Embodiment 3
The present invention in the specific implementation, can also be made up of the material medicine of following parts by weight meter：19 parts of Patrinia heterophylla, another name for Sichuan Province sheep
9 parts of 19 parts of power, 9 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, and adds the water of 15 times of weight of material medicine, immersion
30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with the anhydrous second of 1.5 times of weight of the first filtrate
Alcohol alcohol precipitation 10h, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min, take supernatant under 1500r/min, is dried in vacuo,
Produce.
Embodiment 4
The present invention in the specific implementation, can also be made up of the material medicine of following parts by weight meter：20 parts of Patrinia heterophylla, another name for Sichuan Province sheep
10 parts of 20 parts of power, 10 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, and adds the water of 15 times of weight of material medicine, leaching
Steep 30min, decocting, after big fire is boiled, small fire decocts 30min, filters, obtains the first filtrate, anhydrous with 1.5 times of weight of the first filtrate
Ethanol alcohol precipitation 11h, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min under 1500r/min, takes supernatant, and vacuum is done
It is dry, produce.
Traditional Chinese medicine and pharmacy thinks that cervical carcinoma etiology and pathogenesis is invaded in exopathogen more, or seven feelings, diet internal injury, or inadequate natural endowment, or
It is postpartum, careless through row, show as spleen, kidney, liver zang-fu disharmony, cause " void " simultaneously " phlegm ", " wet ", " stasis of blood ", " stagnant ".《The tumour traditional Chinese medical science
Practice guidelines》、《Chinese tumour great achievement》, it is divided into syndrome of qi stagnation and blood stasis (including Liver depression and Qi stagnation), damp and hot knot poison card, phlegm wet bet
Card, syndrome of yin deficiency of liver and kidney, speen-kidney dificiency card, deficiency of qi and blood demonstrate,prove 6 types.Research shows that the damp and hot knot poison of advanced cervical cancer patients is demonstrate,proved and phlegm
Both account for 14% to wet bet card altogether, also have been reported that syndrome of dampness-heat accounts for 33.33%, and speen-kidney dificiency is demonstrate,proved, and accounts for 25.5% or so [22-
25], illustrate it is wet and it is empty be cervical carcinoma common disease factor, take part in the development of uterine neck carcinogenesis, and show as related syndrome.Therefore, remove
Wet and qi-restoratives is cervical carcinoma critical treatment method.
The present invention links closely the cervical carcinoma interpretation of the cause, onset and process of an illness, using clearing heat and expelling damp and Wen Yang qi-restoratives to treat Patrinia heterophylla in big method, Chinese medicine compound prescription
Bitter, it is slightly sour puckery, it is cool in nature.With eliminating dampness stops band, astringing to arrest bleeding, clearing heat and detoxicating effect.《Shanxi Chinese medicinal herbal》Directly say that it " holds back
Liver eliminating dampness, hemostasis.Control married woman's hip subcutaneous ulcer, leukorrhea with reddish discharge." bittersweet bitter, be slightly cold, it is nontoxic, with clearing heat and detoxicating effect,《Entirely
State's Chinese herbal medicine compilation》Directly say that it " cures mainly abscess of throat." bark of tree of heaven bitter, puckery, it is cold in nature.Heat-clearing and damp-drying drug, inducing astrigency stop-band, antidiarrheal,
Effect of hemostasis.《Explaining abstruseness of the canon of materia medica》Say：" bark of tree of heaven, specially to take the photograph admittedly for, therefore rush down dysentery intestines wind, lose it is turbid collapse band person, and master.So must
It is sick to slide long, begin to be suitable, if new disease flea clothes, exert oneself by force astringent or styptic treatment for spontaneous sweating, his disease must be become and form chronic illness.It is all with tertia is scraped off, it is raw with then
Energy tonneau, vinegar is processed can be astringent or styptic treatment for spontaneous sweating "；《Haigoushen》Say：" controlling dysentery, intestines are slided, and haemorrhoids, which rushes down blood, not to be noted "；《Bencao Shiyi》Then
Say：" main red white protracted dysentery, infantile malnutrition due to digestive disturbances or intestinalparasites worm go scabies, main lower blood "；《Medical center bun will》Add：" letting out lung inverse, dry spleen is wet, promoting the circulation of qi point is damp and hot ".Snake
Machine tool is pungent, hardship, warm-natured；With warming kidney and enhancing body, eliminating dampness, the effect of desinsection, clinic is also used for treatment women with.《The legendary god of farming
Book on Chinese herbal medicine warp》：" housewife people it is cloudy in swell and ache, man's impotence, it is wet itch, eliminating impediment gas, sharp joint, epilepsy, malignant sore." research discovery, cnidium monnieri
Son has antiviral and can be used for treatment kinds of tumors, and growth of its principle active component Osthole to kinds of tumor cells has
There are very strong inhibitory action, such as lung cancer, colon cancer, breast cancer, liver cancer, cervical carcinoma.The medicine phases of the above four are closed, and heat-clearing of gathering altogether is dry
It is wet, inducing astrigency stop-band, warm kidney yang-tonifying, the function of tumor suppression growth.
Chinese medicine compound prescription of the present invention is to be based on the cervical carcinoma interpretation of the cause, onset and process of an illness, is arranging and screening treatment cervical carcinoma Empirical formula and experiment at all times
Research and development are formed on the Research foundation of room, and with heat-clearing and damp-drying drug, inducing astrigency stop-band, warm kidney yang-tonifying, the function of tumor suppression growth is cured mainly：Uterine neck
Cancer, Chinese medical discrimination is damp and hot knot poison card, decline of kidney-YANG card etc., and TCM in Vitro experiment of the present invention is made with good anti-cervical cancer
With, and have no adverse reaction and toxic side effect, correlation test data is as follows：
Anti-cervical cancer Chinese medicine suppresses tumour growth experiment
1. material
1.1 medicine
Patrinia heterophylla is patrinia herb patrinia scabra Bunge (Patrinia rupestris (Pall.) Juss.subsp.scabra
(Bunge) H.J.Wang) or patrinia heterophylla (Patrinia heterophylla Bunge.) root；Bittersweet, is that Solanaceae is planted
The herb or fruit of thing green grass or young crops Qi (Solanumseptemlobum Bunge)；Frutus cnidii Cnidium monnieri (L.) Cuss.,
Alias cicely, is the dry mature fruit of samphire cnidium monnieri；Bark of tree of heaven, Chinese medicine name.For quassia tree-of-heaven
Ailanthus altissima (Mill.) Swingle dry root skin or dry hide.The attached institute of Henan College Of Traditional Chinese Medicine three is purchased from, through river
Southern college of traditional Chinese medicine's Chinese traditional medicine identification expert appraisal is genuine piece
1.2 cell line:Human cervical carcinoma cell lines Hela is purchased from Chinese Academy of Sciences's Shanghai cell bank.
1.3 main agents:RPMI1640 culture mediums, hyclone (gemini, lot number A80E00G), MTT (solarbio,
Lot number：6041051), DMSO (Amresco, lot number：302A0334), trypsase-EDTA digestive juices (solarbio, lot number：
20160713)。
1.4 key instrument equipment:Heraeus cell culture incubators (German Kendro)；Inverted microscope (ZESS), ultraviolet point
Light photometer (BioMate), SG-603 Biohazard Safety Equipments (Bake), ELx800 types ELIASA (BIO-TEK).
2 methods：
2.1 medicines are extracted
The preparation method as described in the content of the invention of the present invention, it is extract obtained to put -20 DEG C of refrigerator preservations.
2.2 cell culture：It is grown in the 1640 culture medium containing 10% hyclone, is placed in 37 DEG C, 5%CO2Incubator,
A subculture, during experiment, cell digestive juice (disodium EDTA containing w=0.02% are changed at interval of 48h
(EDTA) and w=0.25% trypsase is with 1: 1 proportions) digested, and be inoculated in 96 orifice plates or the culture dishes of Φ 100
In.
2.3MTT methods determine cell growth inhibition dose-effect relationship：
With 1 × 104Cells/well is inoculated with 96 hole plane culture plates, in 37 DEG C, 5%CO2, the CO of saturated humidity2Incubator is trained
Support 24 hours.If control group, Chinese medicine group, every group of 6 multiple holes, drug dose be 125 μ g/ml, 250 μ g/ml, 500 μ g/ml,
1000μg/ml、2000μg/ml.Continue to cultivate 48 hours, remove culture supernatant, 0.5mg/ml MTT 100ml are added per hole,
Continue to cultivate 4 hours, carefully suck supernatant, and add 100 μ l DMSO dissolving purple precipitations, in wavelength be 570nm with ELIASA
(/ 630nm), determines OD values.By formula：
Inhibiting rate (%)=(the average A570/630 values of the average A570/630 values/control wells of 1- experimental ports) × 100%
2.4MTT methods determine cyto-inhibition time-effect relationship
From the adherent HeLa cells of exponential phase, after being digested with pancreatin, 2.5 × 10 are adjusted to4Individual/ml cell hangs
Liquid, is seeded in 96 well culture plates, 200 μ l/ holes, 37 DEG C, 5%CO2, 24h is cultivated, 1000 μ g/ml Chinese medicine compound prescription is added, often
6 multiple holes of group, respectively at 24h, 36h, 48h, 60h detection, method is as above.
2.5 statistical method continuous data application software spss13.0 carries out one-way analysis of variance, and enters using the software
Row correlation analysis and curve matching.
3. experimental result
3.1 Chinese medicines of the present invention are to Cervical Cancer HeLa Cells strain growth and the influence of form
Micro- Microscopic observation, cellular control unit adherent growth, cell boundary understands that mitosis figures are obvious,；Chinese medicine compound prescription group
Clearly, kytoplasm is extremely coarse for cell outline, interior to be full of volume particulate material.
Influence of 3.2 Chinese medicines of the present invention to HeLa cell growths
Chinese medicine of the present invention can suppress the growth of Human cervical carcinoma cell line HeLa cell, and with the increase of drug concentration, it is right
Docs-effect dependence (being shown in Table 1) is presented in cell growth inhibition.
Inhibitory action of the Chinese medicine of the present invention of table 1 to HeLa cell growths
Inhibitory action time-effect relationship of 3.3 Chinese medicines of the present invention to HeLa cell growths
As a result show, Chinese medicine of the present invention can suppress the growth of human cervical carcinoma cell lines Hela cells, and increase with the time
Plus, m- effect dependence (as shown in Figure 1) when cell growth suppresses to present.
4. conclusion
Chinese medicine of the present invention is tested with good anti-cervical cancer effect, and this hair in vitro it can be seen from experiment more than
Bright Chinese medicine anti-cervical cancer effect is in dosage and time dependence, with heat-clearing and damp-drying drug, inducing astrigency stop-band, warm kidney yang-tonifying, tumor suppression growth
Function, and have no adverse reaction and toxic side effect, be the innovation on the medicine for treat cervical carcinoma, with actual clinical meaning and
Good application value.
Claims (5)
1. a kind of Chinese medicine for treating cervical carcinoma, it is characterised in that the Chinese medicine is made up of the material medicine of following parts by weight meter：
7-10 parts of 17-20 parts of Patrinia heterophylla, 17-20 parts of another name for Sichuan Province sheep power, 7-10 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, plus
Enter the water of 15 times of weight of material medicine, soak 30min, decocting, after big fire is boiled, small fire decocts 30min, filters, obtains the first filtrate,
With the absolute ethyl alcohol alcohol precipitation 8-12h of 1.5 times of weight of the first filtrate, filtering obtains the second filtrate, the second filtrate under 1500r/min,
10min is centrifuged, supernatant is taken, is dried in vacuo, produces.
2. the Chinese medicine for the treatment of cervical carcinoma according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：7 parts of 17 parts of Patrinia heterophylla, 17 parts of another name for Sichuan Province sheep power, 7 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, raw material is added
The water of 15 times of weight of medicine, immersion 30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with first
The absolute ethyl alcohol alcohol precipitation 8h of 1.5 times of weight of filtrate, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min under 1500r/min
, supernatant is taken, is dried in vacuo, produces.
3. the Chinese medicine for the treatment of cervical carcinoma according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：8 parts of 18 parts of Patrinia heterophylla, 18 parts of another name for Sichuan Province sheep power, 8 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, raw material is added
The water of 15 times of weight of medicine, immersion 30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with first
The absolute ethyl alcohol alcohol precipitation 9h of 1.5 times of weight of filtrate, filtering, obtains the second filtrate, and the second filtrate centrifuges 10min under 1500r/min
, supernatant is taken, is dried in vacuo, produces.
4. the Chinese medicine for the treatment of cervical carcinoma according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：9 parts of 19 parts of Patrinia heterophylla, 19 parts of another name for Sichuan Province sheep power, 9 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, raw material is added
The water of 15 times of weight of medicine, immersion 30min, decocting, after big fire is boiled, small fire decocts 30min, filtering, the first filtrate is obtained, with first
The absolute ethyl alcohol alcohol precipitation 10h of 1.5 times of weight of filtrate, filtering, obtains the second filtrate, and the second filtrate is under 1500r/min, centrifugation
10min, takes supernatant, vacuum drying, produces.
5. the Chinese medicine for the treatment of cervical carcinoma according to claim 1, it is characterised in that by the bulk drug of following parts by weight meter
Thing is made：10 parts of 20 parts of Patrinia heterophylla, 20 parts of another name for Sichuan Province sheep power, 10 parts of frutus cnidii and bark of tree of heaven, material medicine is mixed, and is added former
Expect the water of 15 times of weight of medicine, soak 30min, decocting, after big fire is boiled, small fire decocts 30min, filters, obtains the first filtrate, with the
The absolute ethyl alcohol alcohol precipitation 11h of one 1.5 times of filtrate weight, filtering, obtains the second filtrate, and the second filtrate is under 1500r/min, centrifugation
10min, takes supernatant, vacuum drying, produces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710113507.1A CN107050178A (en) | 2017-02-28 | 2017-02-28 | A kind of Chinese medicine for treating cervical carcinoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710113507.1A CN107050178A (en) | 2017-02-28 | 2017-02-28 | A kind of Chinese medicine for treating cervical carcinoma |
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| Publication Number | Publication Date |
|---|---|
| CN107050178A true CN107050178A (en) | 2017-08-18 |
Family
ID=59622235
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186052C (en) * | 2002-04-04 | 2005-01-26 | 鲁南制药股份有限公司 | Medicine for treatment of pelvic inflammation, its preparation and preparing method |
| CN101816762A (en) * | 2010-05-13 | 2010-09-01 | 贵阳春科药业技术研发有限公司 | Medicinal preparation for treating colpitis and preparation method thereof |
| CN103520651B (en) * | 2013-10-25 | 2015-09-30 | 宋萌颖 | A kind of Chinese medicine composition for the treatment of cervical cancer |
-
2017
- 2017-02-28 CN CN201710113507.1A patent/CN107050178A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1186052C (en) * | 2002-04-04 | 2005-01-26 | 鲁南制药股份有限公司 | Medicine for treatment of pelvic inflammation, its preparation and preparing method |
| CN101816762A (en) * | 2010-05-13 | 2010-09-01 | 贵阳春科药业技术研发有限公司 | Medicinal preparation for treating colpitis and preparation method thereof |
| CN103520651B (en) * | 2013-10-25 | 2015-09-30 | 宋萌颖 | A kind of Chinese medicine composition for the treatment of cervical cancer |
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| 刘世荣: "《刘兰田医学集萃》", 30 June 2015, 中医古籍出版社 * |
| 国家中医药管理局《中华本草》编委会: "《中华本草 7》", 31 December 1999, 上海科学技术出版社 * |
| 徐寒梅: "《抗肿瘤药物药理学实验指南 符合CFDA临床研究申报要求的实验方法》", 31 October 2015, 中国医药科技出版社 * |
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| 王景良等: "从"阳虚阴结"论治恶性肿瘤 ", 《中医杂志》 * |
| 许文学等: "中医治疗癌前病变专题讲座(十)――宫颈炎 ", 《中国中医药现代远程教育》 * |
| 赵建成、谢继增、杨建宇: "《肿瘤方剂大辞典》", 30 April 2009, 中医古籍出版社 * |
| 陈菌骐: "《全国中等中医药学校教材 中药药剂学》", 31 August 1989, 山东科学技术出版社 * |
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Application publication date: 20170818 |
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