CN107050158A - A kind of Chinese medicine composition for treating osteoarthritis and its application - Google Patents
A kind of Chinese medicine composition for treating osteoarthritis and its application Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating osteoarthritis, it is characterised in that the Chinese medicine composition is made up of the bulk drug of following parts by weight：59 parts of corydalis tuber, 59 parts of flos caryophylli, 10 15 parts of asarum, 59 parts of Chinese cassia tree, 10 15 parts of Herba Siegesbeckiae, 10 20 parts of Buddha's hand.The invention further relates to application of the above-mentioned Chinese medicine composition in the medicine for preparing treatment osteoarthritis.Advantage：(1) Chinese medicine composition of the invention has good anti-inflammatory and analgesic effect, and curative effect is better than the combination of similar prescription；(2) Chinese medicine composition of the invention is external used medicine, Small side effects and flavour of a drug number is few, prepares simple, and price is low, and patient is easy to receive.
Description
Technical field
It is a kind of Chinese medicine composition for treating osteoarthritis and its should specifically the present invention relates to technical field of traditional Chinese medicines
With.
Background technology
Osteoarthritis (osteoarthritis, OA) is also known as degenerative joint disease, is to occur diffusivity tortoise with articular cartilage
Split, fibrosis and depigmentation and change one group of clinical signs being characterized group because bone tissue is Hypertrophic, it is later to be more common in the middle age
Chronic progressive joint diseases.The sick incidence of disease increases and raised with the age, according to investigations, current more than 200,000,000 in population in the U.S., just
There is osteoarthritis 45,000,000, the incidence of disease accounts for the 20% of total population, and proportion is higher in the elderly, in more than 50 years old crowd,
OA illness rate is only second to angiocardiopathy, occupies second.In China, shown according to epidemiology survey, the people of 55-64 Sui
The incidence of disease is up to 40% in group, and the illness rate of over-65s crowd is up to 60%~90%.Modern medicine believes that, knee osteoarthritis is
Because knee cartilage retrogression and articular surface edge form the non-inflammatory disease that new bone is characterized.Its cause of disease it is main by
Caused by machinery, biological factor, pathologic process is complicated, and numerous links still end discloses clear completely.
Knee osteoarthritis overall therapeutic is that non-drug therapy and drug therapy are combined, if necessary operative treatment.Non-drug
Treatment is the basis of drug therapy and operative treatment, and such as non-drug therapy is invalid, can select topica according to arthralgia situation
Thing is treated.Current topical medications mainly select whole body analgesic (non-steroid anti-inflammatory drug), and joint cavity injection, cartilage is protected
Agent etc. is protected, often the course for the treatment of is long for these treatments, and very big financial burden is brought to patient, and non-steroid anti-inflammatory drug has necessarily
Bone effect, therefore the skin that simple and quick safely and effectively treatment method is vast gonitis patient be essential will.Chinese patent is public
The Chinese medicine composition of a large amount for the treatment of osteoarthritis, such as Chinese patent are opened
Chinese patent 201610916960 discloses a kind of Chinese medicine composition for the treatment of of arthritis, by the original of following parts by weight
Material medicine is made：10-15 parts of corydalis tuber, 10-15 parts of flos caryophylli, 6-9 parts of asarum, 10-15 parts of Chinese cassia tree, 10-15 parts of frankincense, myrrh 10-
15 parts, 15-20 parts of the root of Dahurain angelica, 15-20 parts of Ligusticum wallichii, 4-6 parts of Radix Notoginseng powder, 15-20 parts of notopterygium root, 15-20 parts of levisticum, the Chinese medicine composition
Compatibility is proper, and each taste medicine complements each other, and treatment of arthritis effect is significantly definite.Chinese patent 2005101207787 discloses one
The Chinese medicine preparation for treating rheumatism and rheumatoid arthritis is planted, the raw material matched by following masses is made：1000 milliliters 25 degree~
50 degree of edible alcoholic solution, 1~10g of spider freeze-drying powder, 1~10g of Ramulus Taxilli, 1~10g of the root of Dahurain angelica, river ox 1~10g of rattan, thoroughly
Bone grass 1~10g, windproof 1~10g, 1~5g of the root of fangji, 1~10g of the root of Chinese clematis, 1~10g of levisticum, 1~3g of bark of ash, 1~10g of notopterygium root,
0.5~1g of asarum.But in the prior art, on the Chinese medicine composition of the treatment osteoarthritis of the present invention, yet there are no report
Road.
The content of the invention
The purpose of the present invention is that there is provided a kind of Chinese medicine composition for treating osteoarthritis for deficiency of the prior art.
Another purpose of the present invention is to provide the purposes of Chinese medicine composition as described above.
To achieve the above object, the present invention is adopted the technical scheme that：
A kind of Chinese medicine composition for treating osteoarthritis, the Chinese medicine composition is by the bulk drug system of following parts by weight
Into：5-9 parts of corydalis tuber, 5-9 parts of flos caryophylli, 10-15 parts of asarum, 5-9 parts of Chinese cassia tree, 10-15 parts of Herba Siegesbeckiae, 10-20 parts of Buddha's hand.
Further, the Chinese medicine composition is made up of the bulk drug of following parts by weight：6-8 parts of corydalis tuber, flos caryophylli 6-8
Part, 12-14 parts of asarum, 6-8 parts of Chinese cassia tree, 12-14 parts of Herba Siegesbeckiae, 13-17 parts of Buddha's hand.
Further, the Chinese medicine composition is made up of the bulk drug of following parts by weight：It is 7 parts of corydalis tuber, 7 parts of flos caryophylli, thin
Pungent 13 parts, 7 parts of Chinese cassia tree, 13 parts of Herba Siegesbeckiae, 15 parts of Buddha's hand.
To realize above-mentioned second purpose, the present invention is adopted the technical scheme that：
As above application of any Chinese medicine composition in the medicine for preparing treatment osteoarthritis.
Further, the medicine adds pharmaceutically acceptable carrier and is prepared into any pharmaceutical dosage form as needed.
Further, the medicine also includes the auxiliary material pharmaceutically allowed.
Further, the formulation of the medicine is ointment, emplastrum, gel, paste, plastics, cataplasm, transdermal patch
Agent, liquid preparation for external use, external preparation for skin film or aerosol for external use.
Further, the pharmaceutically acceptable carrier includes but is not limited to：Mannitol, sorbierite, sodium pyrosulfite, sulfurous
Sour hydrogen sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, monovalence
The carbonate of alkali metal, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, chlorination
Potassium, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol,
Silicon derivative, cellulose and its derivates, alginates, gelatin, polyvinylpyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate,
Calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, beta-schardinger dextrin, phospholipid material, kaolin, talcum powder, stearic acid
Calcium, magnesium stearate.
The invention has the advantages that：
1st, Chinese medicine composition of the invention is external used medicine, Small side effects and flavour of a drug number is few, prepares simple, and price is low,
Patient is easy to receive.
2nd, the proportioning in Chinese prescription of the invention is obtained by a large amount of contrast tests, significantly excellent with effect
Point.
3rd, Herba Siegesbeckiae and Buddha's hand and other traditional Chinese medicine ingredients have significant synergy in Chinese prescription of the invention, significantly
Improve curative effect.
Embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
Bright rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention recorded has been read, art technology
Personnel can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Fixed scope.
The preparation (one) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 1
Bulk drug is weighed according to following parts by weight：7 parts of corydalis tuber, 7 parts of flos caryophylli, 13 parts of asarum, 7 parts of Chinese cassia tree, Herba Siegesbeckiae 13
Part, 15 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (two) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 2
Bulk drug is weighed according to following parts by weight：5 parts of corydalis tuber, 5 parts of flos caryophylli, 10 parts of asarum, 9 parts of Chinese cassia tree, Herba Siegesbeckiae 15
Part, 20 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (three) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 3
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 15 parts of asarum, 5 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (four) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 4
Bulk drug is weighed according to following parts by weight：5 parts of corydalis tuber, 5 parts of flos caryophylli, 10 parts of asarum, 5 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (five) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 5
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 5 parts of flos caryophylli, 10 parts of asarum, 5 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (six) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 6
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 10 parts of asarum, 5 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (seven) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 7
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 15 parts of asarum, 5 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (eight) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 8
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 15 parts of asarum, 9 parts of Chinese cassia tree, Herba Siegesbeckiae 10
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (nine) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 9
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 15 parts of asarum, 9 parts of Chinese cassia tree, Herba Siegesbeckiae 15
Part, 10 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (ten) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 10
Bulk drug is weighed according to following parts by weight：9 parts of corydalis tuber, 9 parts of flos caryophylli, 15 parts of asarum, 9 parts of Chinese cassia tree, Herba Siegesbeckiae 15
Part, 20 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (11) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 11
Bulk drug is weighed according to following parts by weight：6 parts of corydalis tuber, 6 parts of flos caryophylli, 12 parts of asarum, 6 parts of Chinese cassia tree, Herba Siegesbeckiae 12
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (12) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 12
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 6 parts of flos caryophylli, 12 parts of asarum, 6 parts of Chinese cassia tree, Herba Siegesbeckiae 12
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (13) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 13
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 8 parts of flos caryophylli, 12 parts of asarum, 6 parts of Chinese cassia tree, Herba Siegesbeckiae 12
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (14) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 14
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 8 parts of flos caryophylli, 14 parts of asarum, 6 parts of Chinese cassia tree, Herba Siegesbeckiae 12
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (15) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 15
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 8 parts of flos caryophylli, 14 parts of asarum, 8 parts of Chinese cassia tree, Herba Siegesbeckiae 12
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (16) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 16
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 8 parts of flos caryophylli, 14 parts of asarum, 8 parts of Chinese cassia tree, Herba Siegesbeckiae 14
Part, 13 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The preparation (17) of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 17
Bulk drug is weighed according to following parts by weight：8 parts of corydalis tuber, 8 parts of flos caryophylli, 14 parts of asarum, 8 parts of Chinese cassia tree, Herba Siegesbeckiae 14
Part, 17 parts of Buddha's hand.Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3)
Mixing is mixed thoroughly, and ointment is made.The weight ratio of the bulk drug and auxiliary material is 3:2.
The Chinese medicine composition of the embodiment of the present invention is through acute toxicity test, and total dosage is 20g crude drugs/kg, equivalent to facing
300 times of bed adult's 50KG body weight consumptions, Continuous Observation 7 days after administration.As a result show when with Cmax 20g/kg, have no
Animal dead mouse, in the observation period of 7 days, mouse appetite, activity, hair color, state etc. are acted normally.Illustrate from equivalent to
300 times of doses of clinical dosage, have no adverse reaction, show that the Chinese medicine acute toxicity of the present invention is minimum.
The zoopery of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 18
First, the granulomatous influence of rat is caused on button
Rat 84 is taken, male and female half and half, body weight is 170-250g, be randomly divided into seven groups, respectively model group, positive control
Group, one group for the treatment of, two groups for the treatment of, three groups for the treatment of, four groups for the treatment of, five groups, every group 12 for the treatment of.With yellow Jackets 2%,
45mg/kg is anaesthetized, and is anaesthetized about 2 hours often, in dorsal sc otch, is inserted pretreated plastic button and (gone out through high pressure
Bacterium, weighs after 50 DEG C of baking box drying), postoperative suture.Administration：It is administered for the first time within postoperative 4 hours；Positive controls gavage give Ah
A woods 0.05g/kg is taken charge of, concentration is 0.005g/mL.Treat one group and give ointment resulting in embodiment 1, dosage is 2.5g
Ointment/kg.Treat two groups and give ointment resulting in embodiment 2, dosage is 2.5g ointment/kg.Treat three groups and give reality
Ointment obtained by applying in example 3, dosage is 2.5g ointment/kg.Treat four groups and give the ointment prepared by methods described below：
7 parts of corydalis tuber, 7 parts of flos caryophylli, 13 parts of asarum, 7 parts of Chinese cassia tree, fine powder is ground into by above-mentioned raw materials medicine, 100 mesh sieves is crossed, with auxiliary material (rice
Vinegar, white wine, maltose, weight compare 1:1:3) mixing is mixed thoroughly, ointment is made, the weight ratio of the bulk drug and auxiliary material is 3:2, administration
Measure as 2.5g ointment/kg.Treat five groups and give the ointment prepared by methods described below：13 parts of corydalis tuber, 13 parts of flos caryophylli, asarum
8 parts, 13 parts of Chinese cassia tree, 13 parts of frankincense, 13 parts of myrrh, 18 parts of the root of Dahurain angelica, 18 parts of Ligusticum wallichii, 5 parts of Radix Notoginseng powder, 18 parts of notopterygium root, 18 parts of levisticum,
Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3) mixing is mixed thoroughly, is made
Into ointment, the weight ratio of the bulk drug and auxiliary material is 3:2, dosage is 2.5g ointment/kg.Model group gives isometric steaming
Distilled water, daily administration, feed water once, continuous 2 weeks.It is administered after 14d, cervical dislocation puts to death rat, takes out embedding thing and carefully shell
Attachment granuloma is taken, granuloma net weight is weighed, as a result as shown in table 1.
The different dosing thing of table 1 causes the experimental result that rat granulomatous inflammation model influences on button
| Group | Number of rats (n) | Granulation net weight (g) |
| Model group | 12 | 0.195±0.038 |
| Positive controls | 12 | 0.121±0.015 |
| Treat one group | 12 | 0.118±0.017 |
| Treat two groups | 12 | 0.153±0.026 |
| Treat three groups | 12 | 0.156±0.021 |
| Treat four groups | 12 | 0.173±0.021 |
| Treat five groups | 12 | 0.125±0.019 |
It can see from the result of table 1, compared with model group, one group for the treatment of, two groups for the treatment of, three groups for the treatment of, five groups for the treatment of
The granulomatous growth of rat plastic button can be suppressed, difference has statistical significance (P<0.05)；And the meat of one group for the treatment of
Bud net weight illustrates that the antiphlogistic effects of the Chinese medicine composition of embodiment 1 are optimal less than three groups of two groups for the treatment of and treatment.
2nd, paraxylene causes the influence of mice auricle swelling
Packet and administration：Mouse 84 is taken, is divided into 7 groups, respectively model group, positive controls, treatment after weighing immediately
One group, treatment two groups, treatment three groups, treatment four groups, treatment five groups, every group 12.Medication：Positive controls gavage is given
Aspirin 0.06g/kg, concentration is 0.006g/ml.Treat one group and give ointment resulting in embodiment 1, dosage is
3.0g ointment/kg.Treat two groups and give ointment resulting in embodiment 2, dosage is 3.0g ointment/kg.Treat three groups to
Ointment obtained by giving in embodiment 3, dosage is 3.0g ointment/kg.Treat four groups and give what is prepared by methods described below
Ointment：7 parts of corydalis tuber, 7 parts of flos caryophylli, 13 parts of asarum, 7 parts of Chinese cassia tree, fine powder is ground into by above-mentioned raw materials medicine, 100 mesh sieves is crossed, with auxiliary material
(rice vinegar, white wine, maltose, weight compare 1:1:3) mixing is mixed thoroughly, ointment is made, the weight ratio of the bulk drug and auxiliary material is 3:2,
Dosage is 3.0g ointment/kg.Treat five groups and give the ointment prepared by methods described below：13 parts of corydalis tuber, 13 parts of flos caryophylli,
8 parts of asarum, 13 parts of Chinese cassia tree, 13 parts of frankincense, 13 parts of myrrh, 18 parts of the root of Dahurain angelica, 18 parts of Ligusticum wallichii, 5 parts of Radix Notoginseng powder, 18 parts of notopterygium root, levisticum
18 parts, above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3) mixing is mixed
It is even, ointment is made, the weight ratio of the bulk drug and auxiliary material is 3:2, dosage is 3.0g ointment/kg.Model group such as gives at the body
Long-pending distilled water, daily administration, feed water once, continuous 2 weeks.Experimental method：After each group mouse last dose 90min, in mouse
Dimethylbenzene (40 μ L/ only) is uniformly smeared on auris dextra two sides, and left ear is not applied as control, and the neck that breaks after 2h is put to death, and is cut along auricle baseline
Two ears, lay auricle, assay balance is weighed with 7mm card punch at two ear identical positions, using the difference of left and right auricle weight as
Swelling, calculates each group swelling.Swelling (mg)=auris dextra weight-left ear weight.As a result it is as shown in table 2.
The dimethylbenzene induced mice ear swelling test result of table 2
| Group | Number of mice (n) | Swelling (mg) |
| Model group | 12 | 0.0158±0.0018 |
| Positive controls | 12 | 0.0032±0.0006 |
| Treat one group | 12 | 0.0051±0.0012 |
| Treat two groups | 12 | 0.0101±0.0015 |
| Treat three groups | 12 | 0.0118±0.0014 |
| Treat four groups | 12 | 0.0136±0.0017 |
| Treat five groups | 12 | 0.0068±0.0008 |
It can see from the result of table 2, compared with model group, one group for the treatment of, two groups for the treatment of, three groups for the treatment of, five groups for the treatment of
Mice auricle swelling degree is substantially reduced, and difference has statistical significance (P<0.05)；And the swelling of one group for the treatment of is less than controlling
Two groups and three groups for the treatment of are treated, illustrates that the antiphlogistic effects of the Chinese medicine composition of embodiment 1 are optimal.Can also from the result in table
Arrive, four groups with treatment of one group for the treatment of is compared, and under identical dosage, the mice auricle swelling degree of one group for the treatment of substantially drops
Low, both comparing differences have statistical significance (P<0.05), the addition of Herba Siegesbeckiae and Buddha's hand and other groups in this explanation prescription
The combination divided generates extra synergy.
The clinical trial of the present invention treatment osteoarthritis Chinese medicine composition of embodiment 19
1 data and method
1.1 general information
Selection period in March, 2015-2016 year 10, medical Patients with Knee Osteoarthritis 160 is collected, wherein man 72,
Female 88, age distribution is 51-75 Sui, and the course of disease is distributed as 6 months to 10 years.It is randomly divided into four groups, every group 40, four groups of patients
Comparing difference is not statistically significant two-by-two in terms of age, sex, state of an illness weight, with can be with property.
1.2 diagnostic criteria
Reference《Rheumatism branch of Chinese Medical Association arthritis diagnosis and treatment draft guidelines gonitis diagnostic criteria in 2002》Intend
It is fixed：(1) nearly 1 month most of time has gonalgia；(2) there is fricative when movable；(3) the morning stiffness time is less than or equal to
30min；(4) age is more than or equal to 38 years old；(5) bone expands, X-ray film joint space narrows.Meet 1+2+3+4 bars above,
Or 1+2+5 bars or 1+4+5 bars person can diagnose knee OA.According to sign：(1) gonalgia, walking function obstacle, it is tired and on
Exacerbation of symptoms when going downstairs, involves periarticular muscles pain.(2) physical examination knee joint is unrestrained swollen, tenderness at kneecap and inside and outside Xiyan
+, kneecap grinding pain, floating patella test+, knee joint stretches flex and is limited, atrophy of quadriceps femoris.
1.3 treatment method
Treat one group：Method according to embodiment 1 prepares ointment, and the ointment prepared is applied on non-woven fabrics, smears
The thickness of medicine is 1-2mm, takes master point：Outer Xiyan, interior Xiyan, Yinlingquan, Yanglingquan, Ashi Point, auxiliary cave：Liangqiu, the sea of blood, foot
In three, each note of acupuncture point one is fixed, external application 3 hours with medical adhesive tape.
Treat two groups：Method according to embodiment 2 prepares ointment, and the ointment prepared is applied on non-woven fabrics, smears
The thickness of medicine is 1-2mm, takes master point：Outer Xiyan, interior Xiyan, Yinlingquan, Yanglingquan, Ashi Point, auxiliary cave：Liangqiu, the sea of blood, foot
In three, each note of acupuncture point one is fixed, external application 3 hours with medical adhesive tape.
Treat three groups：Method according to embodiment 3 prepares ointment, and the ointment prepared is applied on non-woven fabrics, smears
The thickness of medicine is 1-2mm, takes master point：Outer Xiyan, interior Xiyan, Yinlingquan, Yanglingquan, Ashi Point, auxiliary cave：Liangqiu, the sea of blood, foot
In three, each note of acupuncture point one is fixed, external application 3 hours with medical adhesive tape.
Treat four groups：Ointment is prepared according to methods described below：7 parts of corydalis tuber, 7 parts of flos caryophylli, 13 parts of asarum, 7 parts of Chinese cassia tree,
Above-mentioned raw materials medicine is ground into fine powder, 100 mesh sieves are crossed, (rice vinegar, white wine, maltose, weight compare 1 with auxiliary material:1:3) mixing is mixed thoroughly, is made
Into ointment, the weight ratio of the bulk drug and auxiliary material is 3:2, the ointment prepared is applied on non-woven fabrics, medicine is smeared
Thickness is 1-2mm, takes master point：Outer Xiyan, interior Xiyan, Yinlingquan, Yanglingquan, Ashi Point, auxiliary cave：Liangqiu, the sea of blood, Zusanli,
Each acupuncture point one note, is fixed, external application 3 hours with medical adhesive tape.
The daily external application 1 time of above each group, continuous 2 weeks is 1 course for the treatment of.
1.4 efficacy assessment standard
Formulated according to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》Judge：
Clinical cure：Knee joint swelling, pain disappear, and flexion-extension motion scope recovers normal, and walking is freely；
It is effective：Knee joint swelling disappears or substantially declined substantially, and pain substantially mitigates, and flexion-extension motion scope is normal；
Effectively：Knee joint swelling and pain have to be mitigated and alleviates in various degree, and flexion-extension motion scope also has improvement；
It is invalid：Knee joint swelling and pain are without alleviation.
2 results
Treat after 1 course for the treatment of, count each group total effective rate, total effective rate=(curing number+effective number+significant figure)/total example
Number × 100%.
As a result as shown in table 3, the Chinese medicine composition that can be seen that the embodiment of the present invention 1 from the result in table is closed for knee
Preferably, it is 70% that it treats cure rate after a course for the treatment of to the scorching therapeutic effect of section, and total effective rate is 100%.
3 four groups of curative effect of disease of table compare
| Group | Number of cases (n) | Cure (n) | Effective (n) | Effectively (n) | Invalid (n) | Total effective rate |
| Treat one group | 40 | 28 | 7 | 5 | 0 | 100% |
| Treat two groups | 40 | 10 | 16 | 12 | 2 | 95.0% |
| Treat three groups | 40 | 12 | 15 | 10 | 3 | 92.5% |
| Treat four groups | 40 | 2 | 8 | 16 | 14 | 65% |
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (8)
1. a kind of Chinese medicine composition for treating osteoarthritis, it is characterised in that the Chinese medicine composition is by following parts by weight
Bulk drug is made：5-9 parts of corydalis tuber, 5-9 parts of flos caryophylli, 10-15 parts of asarum, 5-9 parts of Chinese cassia tree, 10-15 parts of Herba Siegesbeckiae, Buddha's hand 10-
20 parts.
2. according to claim 1 treat osteoarthritis Chinese medicine composition, it is characterised in that the Chinese medicine composition be by
The bulk drug of following parts by weight is made：6-8 parts of corydalis tuber, 6-8 parts of flos caryophylli, 12-14 parts of asarum, 6-8 parts of Chinese cassia tree, Herba Siegesbeckiae 12-
14 parts, 13-17 parts of Buddha's hand.
3. according to claim 1 treat osteoarthritis Chinese medicine composition, it is characterised in that the Chinese medicine composition be by
The bulk drug of following parts by weight is made：7 parts of corydalis tuber, 7 parts of flos caryophylli, 13 parts of asarum, 7 parts of Chinese cassia tree, 13 parts of Herba Siegesbeckiae, Buddha's hand 15
Part.
4. application of any Chinese medicine compositions of claim 1-4 in the medicine for preparing treatment osteoarthritis.
5. application according to claim 4, it is characterised in that the medicine adds pharmaceutically acceptable carrier as needed
It is prepared into any pharmaceutical dosage form.
6. application according to claim 4, it is characterised in that the medicine also includes the auxiliary material pharmaceutically allowed.
7. application according to claim 4, it is characterised in that the formulation of the medicine is ointment, emplastrum, gel
Agent, paste, plastics, cataplasm, transdermal patch, liquid preparation for external use, external preparation for skin film or aerosol for external use.
8. application according to claim 4, it is characterised in that described osteoarthritis is gonitis.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839952A (en) * | 2005-12-22 | 2006-10-04 | 清华大学深圳研究生院 | Traditional Chinese medicine for treating rheumatic and rheumatoid arthritis |
| CN104547088A (en) * | 2014-12-20 | 2015-04-29 | 何庆军 | Medicine for treating protrusion of intervertebral disc and osteoarthritis and preparation method thereof |
| CN106236854A (en) * | 2016-10-21 | 2016-12-21 | 上海市静安区芷江西路街道社区卫生服务中心 | The Chinese medicine composition of a kind for the treatment of of arthritis and application thereof |
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2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839952A (en) * | 2005-12-22 | 2006-10-04 | 清华大学深圳研究生院 | Traditional Chinese medicine for treating rheumatic and rheumatoid arthritis |
| CN104547088A (en) * | 2014-12-20 | 2015-04-29 | 何庆军 | Medicine for treating protrusion of intervertebral disc and osteoarthritis and preparation method thereof |
| CN106236854A (en) * | 2016-10-21 | 2016-12-21 | 上海市静安区芷江西路街道社区卫生服务中心 | The Chinese medicine composition of a kind for the treatment of of arthritis and application thereof |
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Application publication date: 20170818 |