CN107050059A - 脚气灵纳米乳膏 - Google Patents

脚气灵纳米乳膏 Download PDF

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CN107050059A
CN107050059A CN201710165313.6A CN201710165313A CN107050059A CN 107050059 A CN107050059 A CN 107050059A CN 201710165313 A CN201710165313 A CN 201710165313A CN 107050059 A CN107050059 A CN 107050059A
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emulsifiable paste
jiaoqiling
beriberi
nanometer
tinea pedis
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成钢
成进学
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Nantong Snakes Treating Institute
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Nantong Snakes Treating Institute
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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Abstract

本发明公开了一种脚气灵纳米乳膏，是属于精细化工小产品脚气灵纳米乳膏配制生产技术领域。是由所述旱獭油蜈蚣用于脚气脚臭类皮肤病乳膏，木槿皮蜂胶用于手足股体癣杀菌止痒乳膏，硫磺大黄杀菌除湿化腐生肌除脚气乳膏，川楝皮海桐皮用于治疗久治不愈的顽癣手足癣乳膏组成。脚癣是皮肤的浅部真菌感染性皮肤病，反复发作，不易治愈，本品用纳米化粉碎的纳米乳以保全天然植物功效和全部营养成分为主；以渗透性强，吸收快，抗菌消炎，去湿止痒，排毒祛湿，消炎生肌，防止真菌感染，治手，足，头，体，股癣顽癣，起效快，疗程短，效果显著，不易复发的天然植物脚气灵纳米乳膏。

Description

脚气灵纳米乳膏
技术领域：
本发明公开了一种脚气灵纳米乳膏，是属于化工小产品配制生产技术领域。
背景技术：
脚气即脚癣是皮肤的浅部真菌感染。病原菌为红色毛癣菌、絮状表皮菌及须毛癣菌。多为间接感染，如用公共浴盆及拖鞋。临床分为水疱型、鳞屑角化型、浸渍型。初期见成群或散在针头大水疱，不易破裂，干燥后疱顶表皮脱落，形成环状鳞屑，新的损害相继出现，互相融合，形成多环状等，即为水疱型。以脱屑，角质增厚，皮肤粗糙干燥为主要表现者，即为鳞屑角化型。指(趾)间皮肤浸渍发白，常因剧痒掻抓摩擦后而引起表皮擦烂，露出潮红糜面等，即为浸渍型。
西医常针对不同临床类型采用相应的外治方法，内服药主要有酮康唑等。中医对手癣有“鹅掌风”，足癣“脚湿气”之称，认为多系外受风毒，内为血燥，凝集皮肤而致。治以清热利湿解毒，内服外治相结合。
发明内容：
本发明的目的在于提供一种脚气灵纳米乳膏。
本发明的技术解决方案是：
1、一种脚气灵纳米乳膏，其特征是，所述旱獭油蜈蚣用于脚气脚臭类皮肤病乳膏，按下列质量份配比组成％
制备方法：
首先旱獭油的制备方法是：将家养的活旱獭处死后，取材进行鼠疫细菌学实验，阴性者，剥皮取油提炼成液体油，冷却后用离心机或分离机除去水分和残渣。
(1)将聚乙二醇400溶剂水浴加热至100℃，在搅拌状态下依次加入十一烯酸和十一烯酸锌，旱獭油、全蝎、蜈蚣、凡士林溶液。
(2)将溶液(1)冷却至20～30℃，加入硅酸铝镁和双甲氨基月桂乙酯、冰片、梅片高速离心搅拌1h，制成混悬液，在胶体磨中混匀进行细化处理，细化液再置于均质机中再进行进一步混匀细化，即纳米化粉碎，制成粒径在0.1-2μm的天然动植物纳米乳液。这种纳米化乳液产品保持了天然动植物功效和全部营养成分，所以乳膏中的功效营养成分更齐全。疗效更佳这种脚气灵纳米乳膏具有良好的渗透性能、渗透速度快，吸收效果好。
本发明充分例用家庭养殖动物资源使用方便，疗效显著，无毒副作用及刺激性，无药物不良反应，用后皮肤细腻光滑。
双甲氨基月桂乙酯是皮肤渗透增强剂，在0.5％～40％的浓度下可以溶解皮肤以及粘膜组织上皮细胞间隙的脂肪微粒，使药物通过细胞间隙透至相关组织，由于它并不对皮肤角质层和上皮细胞产生作用，因此不会损伤皮肤和粘膜上皮。
聚乙二醇400是非离子型惰性溶剂，在100℃的高温下可以完全溶解十一稀酸及其锌盐，并且在常温下保持稳定，不会和透皮剂等活性物质发生反应而影响效果。
硅酸铝镁为增稠和稳定剂，配伍性好，有较好的增稠性、扩散性、悬浮性及持水保湿性能，并具有一定的抗热能力和热稳定性。
本品为抗真菌感染的天然动植物药制剂，主要用于治疗足癣脚臭。真菌感染类皮肤病。
使用方法：将患处洗净，均匀涂抹本品，充分揉搓。第1次连续用药3天后停药如一周后未痊愈可连续再用3天，适每晚临睡前洗脚后用药。
本品的创新性在于用天然动植物药的纳米粉碎技术皮肤渗透增强剂与十一烯酸及能滤毒吸毒离子交换的沸石纳米粉和锌盐配合，形成新型的抗皮肤真菌药物，能够以高于传统疗法用药5～6倍的速度通过上皮屏障达到病灶，疗效显著持久，愈后不复发；本品配方科学，无毒副作用及过敏现象，对皮肤无刺激，并且无异味，使用安全方便。
2、一种脚气灵纳米乳膏，其特征是：所述木槿皮蜂胶用于手足股体癣杀菌止痒乳膏，按下列质量份配比组成％
制备方法
将水杨酸、苯甲酸、升华硫、硼酸、滑石粉、淀粉、苦参、蝉蜕、木槿皮、蜂胶破碎研细，过2500～3000目筛，中心粒径为0.1-2μm的纳米小分子然后再将蜂王浆、薄荷油、灰黄霉素(0.1g片剂)放入95％医用乙醇中充分搅拌均匀，密封3d，即可装瓶。
蜂胶含有黄酮化合物、不低于46种有酸类、酯类、醇类、醛、酮、酚、醚等二十多种生物学活性的有机化合物和多种宏微元素，是“天然的广谱抗菌剂”能有效的杀菌抑菌、是天然“免疫增强剂”；蜂王浆含有多种激素，尤其含有10-羚基-2葵烯酸成分；苦参有清热燥湿杀虫和滋养皮肤的功效；蝉蜕具有散风热、去搔痒的作用；薄荷油镇痛效果好；灰黄霉素杀灭真菌效果显著。
本品具有抗菌消炎、去湿止痒、防止真菌感染、排毒除湿、消炎生肌功效，是用于治疗脚癣(脚气)，除此以外，对凡属真菌感染的皮肤病如手癣、头癣、体癣、股癣均有很好疗效，同时可保养皮肤。
使用方法：先将患部洗净擦干，再用棉球蘸药涂在患处，早晚各1次，连续使用3～5天可彻底治愈。
本品工艺简单，配方合理，起效迅速，疗程短，效果显著持久，不易复发。
3、一种脚气灵纳米乳膏，其特征是，所述硫磺大黄杀菌除湿化腐生肌除脚气乳膏，按下列质量份配比组成％
制备方法
(1)将冰片溶于乙醇溶液。
(2)将乳香、薄荷研末后液化。
(3)将白矾、硫磺、雄黄分别研极细后混合均匀。
(4)将薄荷、大黄热煎后提取浓缩液。
(5)将麝香、阿司匹林加入二甲基亚砜研磨成细粉将上述物充分混合制成混悬液，再在均质机中进行混合细化，再进行纳米化粉碎制成粒径在0.1-2μm的纳米乳液，再加入凡士林升温80～85℃充分搅匀冷却后分装。
本品具有消炎镇痛、杀菌抑菌、祛风除湿、化腐生肌、护肤肌肤等功效，主要用于治疗脚气。将中西医有机结合，运用现代的纳米技术，用药简单量少；见效快，治愈率高，远期疗效好，停药后不复发；无毒副作用无过敏现象，安全可靠。见效快，效果显著持久，使用时，将本品涂抹在患处即可。
4、一种脚气纳米乳膏，其特征是：所述斑蝥密陀僧解毒润燥杀虫止痒治顽癣足癣乳膏，按下列质量份配比组成％
制备方法
(1)将以上各原料进行筛选、称量。
(2)将丹余、煅牡蛎、枯矾、煅膏、龙脑、水龙骨、斑蝥、硫磺、密陀僧、三仙丹固态药用超细微纳米粉碎研磨至极细，并与水杨酸粉、滑石粉、钛白粉3种药物搅拌混合均匀用纳米级粒径超细微化装置处理的过2200-3000目筛，中心粒径为0.1-2μm的纳米小分子的纳米粉。
(3)向物料(2)中加入蛇油(或甘油)，搅拌调匀成稠膏。
(4)将天然中药苦参、蛇床子、地肤子、甘草粉碎成60目的粗粉，加8倍的水制成混悬液，用均质乳化机进行均匀细化；细化液再用纳米级粒径超细微化装置制成粒径为0.1-2μm的纳米化乳液。
(5)将稠膏(3)与纳米化乳液(4)调稀至糊状，然后装袋封口即为成品。
本品具有追风祛湿、清热解毒、杀菌杀虫消炎、活血生肌等功效，不仅适用于脚气(足癣)患者，还可用于手癣、体癣、股癣、花斑癣的治疗。用其治疗顽癣有良效。
使用方法：先洗净手脚患处、用药棉蘸药膏均匀地涂抹于患处，每日2～3次，直至痊愈为止。
本品见效快，效果好，远期疗效稳定，不易复发；无毒副作用及不良反应，愈后无疤痕，安全可靠。
5.一种脚气灵纳米乳膏，其特征是，所述川楝皮海桐皮用于久治不愈的顽癣手足癣乳膏，按下列质量份配比组成％
制备方法：
将川槿皮、海桐皮、大黄、巴豆去油、斑蝥、雄黄、轻粉、水杨酸、苯甲酸、升华硫、硼酸、滑石粉、枯矾、淀粉破碎研细，过2200-3000目筛中心粒径为0.1～2μm的纳米小分子然后再加入蛇油、凡士林升温加热至80℃充分搅拌混合，即得纳米乳膏。
本品具有抗菌消炎，去湿止痒、防止真菌感染之功效，用于治疗顽癣手足癣。使用时将本品涂于患处，早晚各一次。
本品工艺简单，配方合理，起效迅速，疗程短，效果显著持久，不易复发。
下面结合实施例子对本发明进一步阐明：
具体实施方法：
实施例1、一种脚气灵纳米乳膏，其特征是，所述旱獭油蜈蚣用于脚气脚臭类皮肤病乳膏，按下列质量份配比组成％
实施例2、一种脚气灵纳米乳膏，其特征是：所述木槿皮蜂胶用于手足股体癣杀菌止痒乳膏，按下列质量份配比组成％
实施例3、一种脚气灵纳米乳膏，其特征是，所述硫磺大黄杀菌除湿化腐生肌除脚气乳膏，按下列质量份配比组成％
实施例4、一种脚气纳米乳膏，其特征是：所述斑蝥密陀僧解毒润燥杀虫止痒治顽癣足癣乳膏，按下列质量份配比组成％
实施例5、一种脚气灵纳米乳膏，其特征是，所述川楝皮海桐皮用于久治不愈的顽癣手足癣乳膏，按下列质量份配比组成％

Claims (5)

1.一种脚气灵纳米乳膏，其特征是，所述旱獭油蜈蚣用于脚气脚臭类皮肤病乳膏，按下列质量份配比组成％
2.一种脚气灵纳米乳膏，其特征是：所述木槿皮蜂胶用于手足股体癣杀菌止痒乳膏，按下列质量份配比组成％
3.一种脚气灵纳米乳膏，其特征是，所述硫磺大黄杀菌除湿化腐生肌除脚气乳膏，按下列质量份配比组成％
4.一种脚气纳米乳膏，其特征是：所述斑蝥密陀僧解毒润燥杀虫止痒治顽癣足癣乳膏，按下列质量份配比组成％
5.一种脚气灵纳米乳膏，其特征是，所述川楝皮海桐皮用于久治不愈的顽癣手足癣乳膏，按下列质量份配比组成％
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108403758A (zh) * 2018-05-10 2018-08-17 梁玉华 去脚气膏及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103223095A (zh) * 2013-04-28 2013-07-31 王树庆 一种治疗脚气的药膏
CN104352738A (zh) * 2014-11-20 2015-02-18 樊秀英 一种治疗脚气的药膏
CN104906203A (zh) * 2015-04-24 2015-09-16 南通蛇类治疗研究所 治手足癣无痛性纳米乳膏

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103223095A (zh) * 2013-04-28 2013-07-31 王树庆 一种治疗脚气的药膏
CN104352738A (zh) * 2014-11-20 2015-02-18 樊秀英 一种治疗脚气的药膏
CN104906203A (zh) * 2015-04-24 2015-09-16 南通蛇类治疗研究所 治手足癣无痛性纳米乳膏

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108403758A (zh) * 2018-05-10 2018-08-17 梁玉华 去脚气膏及其制备方法

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