CN107049943A - Milk cow Ceftiofur Hydrochloride injecta and preparation method thereof - Google Patents
Milk cow Ceftiofur Hydrochloride injecta and preparation method thereof Download PDFInfo
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- CN107049943A CN107049943A CN201710323608.1A CN201710323608A CN107049943A CN 107049943 A CN107049943 A CN 107049943A CN 201710323608 A CN201710323608 A CN 201710323608A CN 107049943 A CN107049943 A CN 107049943A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Abstract
The invention provides a kind of milk cow Ceftiofur Hydrochloride injecta, it includes the component of following mass parts：55~100 parts of 5~10 parts of Ceftiofur Hydrochloride, 0.5~3 part of suspending agent, 0.05~5 part of flocculant, 0.01~2 part of emulsifying agent, 0.1~2 part of antioxidant and lipid solvent.The parenteral solution dispersion stabilization and syringeability are good, after milk beef injection to abandon the milk phase short, have broad application prospects.The present invention also provides the preparation method of the milk cow Ceftiofur Hydrochloride injecta, and this method is simple to operate, suitable for commercial Application.
Description
Technical field
The invention belongs to animal drug field, in particular it relates to a kind of milk cow Ceftiofur Hydrochloride injecta and its system
Preparation Method.
Background technology
Ceftiofur (Ceftiofur), also known as Ceftlofur, are the third generation cephalo antibiotics of animal specific.Cephalo thiophene
Furan has spectrum bactericidal action, and antibacterial activity is strong, effective to gram-positive bacteria and negative bacterium (including production lactamase bacterium).
Its sensitive bacteria mainly has pasteurella multocida, pasteurella haemolytica, Actinobacillus pleuropneumoniae, salmonella, large intestine bar
Bacterium, streptococcus, staphylococcus, haemophilus etc., are not likely to produce antibody-resistant bacterium and cross resistance, are mainly used in treatment a variety of dynamic
Various infection, are widely used in livestock breeding industry caused by thing sensitive bacteria.
The preparation of current China's approval has Ceftiofur soluble powder and suspension injection, and Ceftiofur is intramuscular and subcutaneous
Absorb rapid after injection, bioavilability is high, high with vivo protein Percentage bound, and Ceftiofur residual in tissue is low, peace
Good perfection, is veterinary drug sterilizing power most strong antibiotic on the market.But the Residues in Milk that Ceftiofur is easily produced in milk cow,
So that injected the milk cow of Ceftiofur to abandon the milk phase longer, be added to production cost, reduce production efficiency, and Ceftiofur is noted
The syringeability for penetrating liquid is poor, easily settles, less stable, is unfavorable for injecting parenteral solution.
The content of the invention
In view of this, the present invention provides a kind of milk cow Ceftiofur Hydrochloride injecta and preparation method thereof, with solution
State problem.
Specifically, the present invention is adopted the following technical scheme that：
A kind of milk cow Ceftiofur Hydrochloride injecta, it includes the component of following mass parts：Ceftiofur Hydrochloride 5~10
Part, 0.5~3 part of suspending agent, 0.05~5 part of flocculant, 0.01~2 part of emulsifying agent, 0.1~2 part of antioxidant and lipid solvent 55
~100 parts.
Based on above-mentioned, the suspending agent is aluminum stearate, chitosan, sodium carboxymethylcellulose, PVP, hypromellose
One kind or at least two combination in element, gelatin, glycerine.
Based on above-mentioned, the flocculant is one kind or at least two combination in citric acid, tartaric acid, silica.
Based on above-mentioned, the emulsifying agent is rilanit special, sorbitol anhydride oleate, polyethenoxy sorbitan list
Oleate, dodecyl sodium sulfate, oleoyl polyoxyethylene, soybean lecithin, one kind in glycerin monostearate or at least two
The combination planted.
Based on above-mentioned, the antioxidant be vitamin E, 2,6- di-tert-butyl-4-methy phenols, butylated hydroxy anisole,
One kind or at least two combination in ascorbyl palmitate.
Based on above-mentioned, the lipid solvent is one in white oil, cottonseed oil, castor oil, diacetine, soybean oil
Kind or at least two combination.
Based on above-mentioned milk cow Ceftiofur Hydrochloride injecta, it includes the component of following mass parts：Ceftiofur Hydrochloride 5
~10 parts, 0.5~3 part of aluminum stearate, 0.05~5 part of citric acid, 0.01~2 part of rilanit special, 0.1~2 part of vitamin E,
5~20 parts of 50~80 parts of soybean oil and white oil.
A kind of preparation method of above-mentioned milk cow Ceftiofur Hydrochloride injecta, comprises the following steps：
3rd/2nd to five/5ths of suspending agent and the lipid solvent are well mixed, 110~140 DEG C are heated to,
0.5~2h is incubated, 70~80 DEG C are cooled to, factice is made；
The flocculant, the emulsifying agent and the factice are well mixed, room temperature is cooled to, mixed solution is made；
The lipid solvent of surplus, the antioxidant, the Ceftiofur Hydrochloride and the mixed solution are mixed equal
It is even, using high-speed shearing emulsion machine under 2000~6000r/min rotating speeds, emulsification grinding 2~3h, then by irradiation sterilization at
Reason, is made the milk cow Ceftiofur Hydrochloride injecta.
Compared with prior art, the present invention is with prominent substantive distinguishing features and significantly progressive.Specifically, it is of the invention
The milk cow of offer with Ceftiofur Hydrochloride injecta include Ceftiofur Hydrochloride, suspending agent, flocculant, emulsifying agent, antioxidant and
Lipid solvent, the suspending agent can increase the viscosity of decentralized medium to reduce the sinking speed of particulate；The flocculant makes described
Ceftiofur Hydrochloride forms loose aggregation in decentralized medium, and when receiving less shearing force, the aggregation is broken
Split so that milk cow is strong with Ceftiofur Hydrochloride injecta plasticity, parenteral solution not wall built-up；The emulsifying agent makes the hydrochloric acid cephalo
Thiophene furan forms the dispersion liquid of the less stabilization of particle diameter in decentralized medium, promotes absorption of the milk cow to Ceftiofur Hydrochloride；It is described
Oxidant can delay or suppress to demonstrate,prove the milk cow to be carried out with each component oxidizing process in Ceftiofur Hydrochloride injecta, is made described
Preservative need not be added in milk cow Ceftiofur Hydrochloride injecta；The lipid solvent is conducive to milk using edible grease
Absorption of the ox to the milk cow Ceftiofur Hydrochloride injecta；The Ceftiofur Hydrochloride, suspending agent, flocculant, emulsifying agent,
Antioxidant and lipid solvent collective effect, make milk cow Ceftiofur Hydrochloride injecta have good dispersion stabilization and
Syringeability, shortens and abandons the milk phase after milk cow Ceftiofur Hydrochloride injecta described in milk beef injection.After testing, the milk cow is used
Granularity≤10 μm of Ceftiofur Hydrochloride injecta, abandon the milk phase≤12h.
Meanwhile, the present invention is also provided to be used in the preparation method of the milk cow Ceftiofur Hydrochloride injecta, this method
2000~6000r/min rotating speeds carry out emulsification grinding, to reduce the granularity of the milk cow Ceftiofur Hydrochloride injecta, so as to
Infiltration rate of the milk cow to Ceftiofur Hydrochloride；By irradiation sterilized under cryogenic, it is to avoid Ceftiofur Hydrochloride by
It is destructurized after heat, influence the using effect of the milk cow Ceftiofur Hydrochloride injecta；And this method is simple to operate,
Condition is easy to control, suitable for commercial Application.
Embodiment
Below by embodiment, technical scheme is described in further detail.
Embodiment 1
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and it is made up of the component of following mass parts：Salt
Sour 10 parts of Ceftiofur, 1 part of suspending agent, 0.1 part of citric acid, 0.02 part of rilanit special, 0.5 part of vitamin E, soybean oil 60
5 parts of part and white oil；The suspending agent is aluminum stearate.
The present invention also provides the preparation method of the milk cow Ceftiofur Hydrochloride injecta, and it comprises the following steps：
The 50% of the amount of the suspending agent and the soybean oil is well mixed, 110~120 DEG C are heated to, 1h is incubated, it is cold
But to 70~80 DEG C, factice is made；
The citric acid, the rilanit special and the factice are well mixed, room temperature is cooled to, mixing is made molten
Liquid；
The soybean oil of surplus, the white oil, the vitamin E, the Ceftiofur Hydrochloride and the mixing is molten
Liquid be well mixed, using high-speed shearing emulsion machine under 3000r/min rotating speeds, emulsification grinding 2h, then by irradiation sterilization at
Reason, is made the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 2
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and the present embodiment exists with implementing 1 difference
In：The suspending agent is chitosan.
The present invention provides the preparation method be the same as Example 1 of the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 3
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and the present embodiment exists with implementing 1 difference
In：The suspending agent is sodium carboxymethylcellulose.
The present invention provides the preparation method be the same as Example 1 of the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 4
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and it is made up of the component of following mass parts：Salt
Sour 5 parts of Ceftiofur, 1 part of PVP, 1 part of hydroxypropyl methylcellulose, 0.3 part of gelatin, 0.7 part of glycerine, 5 parts of flocculant, dodecane
1 part of base sodium sulfonate, 1 part of oleoyl polyoxyethylene, 1 part of ascorbyl palmitate, 1 part of butylated hydroxy anisole, 90 parts of castor oil
With 10 parts of cottonseed oil；The flocculant is citric acid.
The present invention also provides the preparation method of the milk cow Ceftiofur Hydrochloride injecta, and it comprises the following steps：
The PVP, the hydroxypropyl methylcellulose, the gelatin, the glycerine and 45% castor oil are mixed
Uniformly, 130~140 DEG C are heated to, 1h is incubated, is cooled to 70~80 DEG C, factice is made；
The flocculant, the dodecyl sodium sulfate, the oleoyl polyoxyethylene and the factice are well mixed, it is cold
But to room temperature, mixed solution is made；
By the castor oil of surplus, the cottonseed oil, the ascorbyl palmitate, the butylhydroxy fennel
Ether, the Ceftiofur Hydrochloride and the mixed solution are well mixed, using high-speed shearing emulsion machine in 6000r/min rotating speeds
Under, then emulsification grinding 1h handles by irradiation sterilization, the milk cow Ceftiofur Hydrochloride injecta is made.
Embodiment 5
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and the present embodiment exists with implementing 1 difference
In：The flocculant is tartaric acid.
The present invention provides the preparation method be the same as Example 1 of the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 6
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and the present embodiment exists with implementing 1 difference
In：The flocculant is tartaric acid.
The present invention provides the preparation method be the same as Example 1 of the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 7
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and the present embodiment exists with implementing 1 difference
In：The flocculant is silica.
The present invention provides the preparation method be the same as Example 1 of the milk cow Ceftiofur Hydrochloride injecta.
Embodiment 8
The present embodiment provides a kind of milk cow Ceftiofur Hydrochloride injecta, and it is made up of the component of following mass parts：Salt
Sour 8 parts of Ceftiofur, 2 parts of aluminum stearate, 0.2 part of citric acid, 1 part of rilanit special, 1 part of vitamin E, 80 parts of soybean oil and
10 parts of white oil；The flocculant is citric acid.
The present invention also provides the preparation method of the milk cow Ceftiofur Hydrochloride injecta, and it comprises the following steps：
The 60% of the amount of the aluminum stearate and the soybean oil is well mixed, 120~130 DEG C, insulation are heated to
1.5h, is cooled to 70~80 DEG C, and factice is made；
The citric acid, the rilanit special and the factice are well mixed, room temperature is cooled to, mixing is made molten
Liquid；
The soybean oil of surplus, the white oil, the vitamin E, the Ceftiofur Hydrochloride and the mixing is molten
Liquid is well mixed, using high-speed shearing emulsion machine under 4000r/min rotating speeds, emulsification grinding 1.5h, then by irradiation sterilization
Processing, is made the milk cow Ceftiofur Hydrochloride injecta.
Performance test
Reference veterinary medical quality standard compendium 2006~2011 editions, the milk cow Ceftiofur Hydrochloride provided embodiment 1~8
Parenteral solution is tested.Test result is as shown in table 1.
The test result for the milk cow Ceftiofur Hydrochloride injecta that the embodiment 1~8 of table 1 is provided
The milk cow that embodiment 1 and embodiment 8 are provided with Ceftiofur Hydrochloride injecta after 60 DEG C of storages 10 days, with reference to beast
Medicine quality standard collects 2006~2011 editions and tested.Test result is as shown in table 2.
The embodiment 1 of table 2, embodiment 8 provide milk cow with Ceftiofur Hydrochloride injecta 60 DEG C storage 10 days after survey
Test result
From table 1, table 2, milk cow Ceftiofur Hydrochloride injecta drug content of the invention, granularity, character, drawn needle
Experiment and sedimentation volume ratio meet the standard of veterinary medical quality standard compendium 2006-2011 editions, with good dispersion stabilization
And syringeability.
The milk cow provided using embodiment 8 is injected with Ceftiofur Hydrochloride injecta to 20 cow heads, with cephalo thiophene
Furan meter, per 1kg body weight 2.2mg, 1 times a day, is used in conjunction 5, according to No. 1025 bulletin -13-2008 of Ministry of Agriculture examination criteria, surveys
Determine Ceftiofur residual quantity in milk to change over time.Measurement result is shown in Table 3.
Ceftiofur residual quantity is changed over time in the milk of table 3
| Adopt the milk time (h) | Ceftiofur residual quantity (μ g/kg) |
| 2 | 179.82 |
| 4 | 125.17 |
| 6 | 101.36 |
| 8 | 81.39 |
| 10 | 29.61 |
| 12 | Do not detect |
| 16 | Do not detect |
As shown in Table 3, the milk cow that provides of the present invention be easy to Ceftiofur Hydrochloride injecta body absorb, effect it is good, see
Effect is fast, abandons the milk phase≤12h after being injected to milk cow, can significantly improve the economic benefit of raising dairy cattle.
Finally it should be noted that：The above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof；To the greatest extent
The present invention is described in detail with reference to preferred embodiments for pipe, those of ordinary skills in the art should understand that：Still
The embodiment of the present invention can be modified or equivalent substitution is carried out to some technical characteristics；Without departing from this hair
The spirit of bright technical scheme, it all should cover among claimed technical scheme scope of the invention.
Claims (8)
1. a kind of milk cow Ceftiofur Hydrochloride injecta, it is characterised in that it includes the component of following mass parts：Hydrochloric acid cephalo
5~10 parts of thiophene furan, 0.5~3 part of suspending agent, 0.05~5 part of flocculant, 0.01~2 part of emulsifying agent, 0.1~2 part of antioxidant and fat
55~100 parts of class solvent.
2. milk cow Ceftiofur Hydrochloride injecta according to claim 1, it is characterised in that the suspending agent is tristearin
One kind in sour aluminium, chitosan, sodium carboxymethylcellulose, PVP, hydroxypropyl methylcellulose, gelatin, glycerine or at least two
Combination.
3. milk cow Ceftiofur Hydrochloride injecta according to claim 1 or 2, it is characterised in that the flocculant is
One kind or at least two combination in citric acid, tartaric acid, silica.
4. milk cow Ceftiofur Hydrochloride injecta according to claim 3, it is characterised in that the emulsifying agent is hydrogenation
Castor oil, sorbitol anhydride oleate, polyoxyethylene sorbitan monooleate, dodecyl sodium sulfate, oleoyl polyoxy second
One kind or at least two combination in alkene, soybean lecithin, glycerin monostearate.
5. milk cow Ceftiofur Hydrochloride injecta according to claim 4, it is characterised in that the antioxidant is given birth to for dimension
Plain E, 2,6- di-tert-butyl-4-methy phenols, butylated hydroxy anisole, one kind in ascorbyl palmitate or at least two
Combination.
6. according to claim 5 or described milk cow Ceftiofur Hydrochloride injecta, it is characterised in that the lipid solvent is
One kind or at least two combination in white oil, cottonseed oil, castor oil, diacetine, soybean oil.
7. according to claim 6 or described milk cow Ceftiofur Hydrochloride injecta, it is characterised in that it includes following matter
Measure the component of part：5~10 parts of Ceftiofur Hydrochloride, 0.5~3 part of aluminum stearate, 0.05~5 part of citric acid, rilanit special
5~20 parts of 0.01~2 part, 0.1~2 part of vitamin E, 50~80 parts of soybean oil and white oil.
8. a kind of preparation method of the milk cow Ceftiofur Hydrochloride injecta described in any one of claim 1~7, including it is following
Step：
3rd/2nd to five/5ths of the suspending agent and the lipid solvent are well mixed, 110~140 DEG C are heated to,
0.5~2 h is incubated, 70~80 DEG C are cooled to, factice is made；
The flocculant, the emulsifying agent and the factice are well mixed, room temperature is cooled to, mixed solution is made；
The lipid solvent, the antioxidant, the Ceftiofur Hydrochloride and the mixed solution of surplus are well mixed, so
Afterwards under 2000~6000 r/min rotating speeds, emulsification 2~3 h of grinding handle by irradiation sterilization, the milk cow hydrochloric acid are made
Cefliofur injection.
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| CN201710323608.1A CN107049943B (en) | 2017-05-10 | 2017-05-10 | Ceftiofur hydrochloride injection for dairy cattle and preparation method thereof |
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| CN107049943B CN107049943B (en) | 2020-02-14 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111202753A (en) * | 2020-02-19 | 2020-05-29 | 湖南加农正和生物技术有限公司 | Medicine composition for preventing and treating piglet infection and improving immunity and swine fever antibody and using method |
| CN111228211A (en) * | 2020-01-14 | 2020-06-05 | 开封嘉骏生物科技有限公司 | Production formula and production process of ceftiofur hydrochloride injection |
| CN112870159A (en) * | 2021-02-03 | 2021-06-01 | 西安乐道生物科技有限公司 | Veterinary ceftiofur hydrochloride injection for clearing heat, detoxifying and reducing fever and preparation method thereof |
| CN113995719A (en) * | 2021-10-19 | 2022-02-01 | 河南中盛动物药业有限公司 | Application of sodium carboxymethylcellulose in improvement of amoxicillin and colistin sulfate injection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401787A (en) * | 2008-11-19 | 2009-04-08 | 肖希龙 | Ceftiofur long-acting injection and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111228211A (en) * | 2020-01-14 | 2020-06-05 | 开封嘉骏生物科技有限公司 | Production formula and production process of ceftiofur hydrochloride injection |
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| CN112870159A (en) * | 2021-02-03 | 2021-06-01 | 西安乐道生物科技有限公司 | Veterinary ceftiofur hydrochloride injection for clearing heat, detoxifying and reducing fever and preparation method thereof |
| CN113995719A (en) * | 2021-10-19 | 2022-02-01 | 河南中盛动物药业有限公司 | Application of sodium carboxymethylcellulose in improvement of amoxicillin and colistin sulfate injection |
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