CN107043700A - A kind of magnetic control system for genetic test - Google Patents
A kind of magnetic control system for genetic test Download PDFInfo
- Publication number
- CN107043700A CN107043700A CN201710428548.XA CN201710428548A CN107043700A CN 107043700 A CN107043700 A CN 107043700A CN 201710428548 A CN201710428548 A CN 201710428548A CN 107043700 A CN107043700 A CN 107043700A
- Authority
- CN
- China
- Prior art keywords
- array
- magnet coil
- control system
- genetic test
- dragging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002068 genetic effect Effects 0.000 title claims abstract description 32
- 238000012360 testing method Methods 0.000 title claims abstract description 31
- 238000002156 mixing Methods 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims description 14
- 229910000976 Electrical steel Inorganic materials 0.000 claims description 4
- 238000003491 array Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000005611 electricity Effects 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 11
- 108090000623 proteins and genes Proteins 0.000 abstract description 9
- 230000010354 integration Effects 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000026350 Inborn Genetic disease Diseases 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 208000016361 genetic disease Diseases 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000005336 cracking Methods 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
Abstract
The invention discloses a kind of magnetic control system for genetic test, including mixing array (101) and dragging array (102) by being arranged towards identical magnet coil；The magnet coil (1) mixed in array (101) is arranged in a ring；Magnet coil (1) in the dragging array (102) is arranged in a linear, and the magnet coil on dragging array (102) top is connected with mixing array (101).The present invention is a kind of magnetic control system easy to control, can be used for the integration detection of gene.
Description
Technical field
The present invention relates to a kind of magnetic control system for genetic test, belong to technical field of medical detection.
Background technology
Genetic test is the technology detected by blood, other body fluid or cell to DNA, is to take detected person to come off
Oral Mucosal Cells or other histocytes, expand after its gene information, by particular device in detected person's cell
DNA molecular information detects that the risk that precognition body is suffered from the disease analyzes the various genetic profiles contained by it, so that people
The gene information of oneself is will appreciate that, so that living environment and habits and customs by improving oneself, it is to avoid or delay the hair of disease
It is raw.
Genetic test can diagnose the illness, and can be used for the prediction of disease risks.Medical diagnosis on disease is to use genetic test skill
Art detects the mutator for causing genetic disease.Current most widely used genetic test is the inspection of neonate's genetic disease
The auxiliary diagnosis of survey, the diagnosis of genetic disease and some common diseases.There is more than 1000 kinds of genetic disease can be by gene at present
Detection technique makes diagnosis.
Usually used sample is biological tissue cell during due to genetic test, therefore needs to enter cell during detection gene
After the steps such as row cracking, cleaning, amplification, the mode of optical detection is recycled to go to detect gene.Due to being related to not in each step
Same processing, usual sample is needed to carry out the processing of different step respectively by multiple equipment, and detection is more bothered, and is being entered
During row different step, transfer sample is also needed to sometimes to different carriers, and this process is readily incorporated pollution, influence detection essence
Degree.Therefore, it is possible to which each step of genetic test is completed in same kit, become the main development studied now
Direction.At the same time, it is a kind of also necessarily to have corresponding demand to the equipment that kit carries out integrated treatment, and this kind is set
Standby research emphasis, is how in the case where not contacting sample, and mobile sample enters different detecting steps.
The content of the invention
It is an object of the present invention to provide a kind of magnetic control system for genetic test.It is a kind of magnetic easy to control
Control system, can be used for the integration detection of gene.
Technical scheme：A kind of magnetic control system for genetic test, is characterized in:Including by towards identical
The mixing array and dragging array of magnet coil arrangement；Magnet coil in the mixing array is arranged in a ring；It is described
Magnet coil in dragging array is arranged in a linear, and the magnet coil on dragging array top is connected with mixing array.
In the above-mentioned magnetic control system for genetic test, preferably, the magnet coil of the dragging array is divided into a left side
The right side two is arranged, wherein any one magnet coil of a row is just between two adjacent electromagnetic coils of another row.
Be previously described in the magnetic control system of genetic test, it is described mix array in each magnet coil along clockwise or
Counterclockwise it is sequentially completed make and break process, and repeatedly circulation.
It is previously described in the magnetic control system of genetic test, each magnet coil in the dragging array is mixing array
Complete after work, make and break process is sequentially completed from one end close to mixing array to the other end.
It is previously described in the magnetic control system of genetic test, each magnet coil in the dragging array is mixing array
Complete work after, from close to mix array one end to the other end by it is two neighboring be one group in the way of, be sequentially completed break-make mistake
Journey.
It is previously described in the magnetic control system of genetic test, described each magnet coil stated in dragging array is mixing battle array
Row complete work after, from close to mix array one end to the other end by it is two neighboring or three be one group in the way of, it is complete successively
Into make and break process；The magnet coil of each of which group includes most connecing with it in a magnet coil and another row in wherein one row
One or two near magnet coil.
It is previously described in the magnetic control system of genetic test, in the mixing array, the magnetic core of magnet coil is by 3
0.65mm*4mm*60mm silicon steel sheet close-packed arrays are formed, and enamel-covered wire that 6 layer line footpaths are 0.25mm is full of outside magnetic core (about
1200 binding circles)；The dragging array magnetic core is formed by 3 0.65mm*6mm*60mm silicon steel sheet close-packed arrays；Outside magnetic core
It is full of the enamel-covered wire (about 1200 binding circle) that 6 layer line footpaths are 0.25mm.
Logical 15V electricity measures its magnetic field intensity with gaussmeter and mixes array about 2000Gs, dragging array about 2200Gs.Electromagnetic wire
Dragging effect when circle remote is from magnetic bead 1.3mm is also not in magnet coil overheat condition preferably.
It is previously described in the magnetic control system of genetic test, the magnet coil break-make interval mixed in array is adjustable, control
In 15ms to 500ms.
It is previously described in the magnetic control system of genetic test, mixes the magnet coil break-make Separation control in array in 35ms
To 65ms, Blending Efficiency of Blending is optimal.
Compared with prior art, the present invention utilizes the arrangement of magnet coil, and formation can produce dynamic magnetic field permutation, and then
Using high-speed circulating movement and low speed dragging is carried out to magnetic carrier, when for gene detecting kit, you can utilize magnetic
Property carrier high-speed circulating movement, be sample is carried out in lysate sufficiently mix cracking, recycle low speed drag make magnetic
Carrier drives sample to carry out multiple working procedure processing respectively into different regions, so that gene integration detection referred to as may.
In addition, the present invention combines the control of its break-make using the arrangement mode of magnet coil, efficiently magnetic can be carried
Body carries out mixing campaign, reaches optimal lytic effect, while can also slowly drive magnetic carrier to be moved in kit, can
It is passed through narrow and small hole, be not easily blocked.
Brief description of the drawings
Fig. 1 is the single electromagnetic coil array structural representation of the present invention；
Fig. 2 is the double electromagnetic coil array structural representation of the present invention.
Mark in accompanying drawing for：1- magnet coils, 101- mixes array, 102- dragging arrays.
Embodiment
The present invention is further illustrated with reference to the accompanying drawings and examples, but be not intended as to the present invention limit according to
According to.
Embodiment 1.A kind of magnetic control system for genetic test, as shown in Figure 1:Including by towards identical magnet coil
The mixing array 101 and dragging array 102 of arrangement；The magnet coil 1 mixed in array 101 is arranged in a ring；Institute
The magnet coil 1 stated in dragging array 102 is arranged in a linear, and the magnet coil and mixing array 101 on dragging array 102 top
It is connected.
Described each magnet coil 1 mixed in array 101 is sequentially completed make and break process clockwise or counterclockwise,
And repeatedly circulation.Or described each magnet coil 1 mixed in array 101 is sequentially completed make and break process according to the figure of eight, and it is many
Secondary circulation, more preferably, experiment shows that its lysis efficiency when being cracked for sample is higher to Blending Efficiency of Blending.
Each magnet coil 1 in the dragging array 102, can be according to single after the completion work of array 101 is mixed
Break-make mode is run, and such as A starts；Then A stops, and B starts；Then B stops, and C starts；Then C stops, by that analogy.
Can also be in the way of 2 one group of position control, such as AB starts simultaneously, and then AB stops, and BC starts；By that analogy.
Can also A start after a period of time B and start, AB, which is also turned on A after a period of time, to be stopped；B is individually turned on, and C is opened after a period of time
Dynamic, BC is also turned on a period of time, and B shut-offs, by that analogy, experiment prove that this mode is more suitable when dragging nanometer magnetic bead
Freely, the success rate of dragging magnetic bead is more than 95%.
Embodiment 2.A kind of magnetic control system for genetic test, as shown in Figure 2:Including by towards identical magnet coil
The mixing array 101 and dragging array 102 of arrangement；The magnet coil 1 mixed in array 101 is arranged in a ring；Institute
The magnet coil 1 stated in dragging array 102 is arranged in a linear, and the magnet coil and mixing array 101 on dragging array 102 top
It is connected.1 point of the magnet coil of the dragging array 102 arranges for left and right two, wherein any one magnet coil 1 of a row is just to another
Between two adjacent electromagnetic coils 1 of one row.
Described each magnet coil 1 mixed in array 101 is sequentially completed make and break process clockwise or counterclockwise,
And repeatedly circulation.Or described each magnet coil 1 mixed in array 101 is sequentially completed make and break process according to the figure of eight, and it is many
Secondary circulation, more preferably, experiment shows that its lysis efficiency when being cracked for sample is higher to Blending Efficiency of Blending.
Described each magnet coil 1 stated in dragging array 102, can be by 2 positions after the completion work of array 101 is mixed
The mode of one group of control, such as AB start simultaneously, and then AB stops, and BC starts；By that analogy.
Can also be in the way of 3 one group of position control, such as ABC starts simultaneously；Then ABC stops, and BCD starts；Then BCD
Stop, CDE starts, by that analogy.
The present invention, can be mixed by magnetic control mode in use, apply in the integrated detection equipment of integrated kit
Sample in even kit, and drive sample in kit into the different zones of kit, to carry out different detection processes.
Claims (9)
1. a kind of magnetic control system for genetic test, it is characterised in that:Including by being formed towards the arrangement of identical magnet coil
Mixing array (101) and dragging array (102)；The magnet coil (1) mixed in array (101) is arranged in a ring；Institute
The magnet coil (1) stated in dragging array (102) is arranged in a linear, and magnet coil and the mixing on dragging array (102) top
Array (101) is connected.
2. the magnetic control system according to claim 1 for genetic test, it is characterised in that:The dragging array (102)
Magnet coil (1) be divided into two row of left and right, wherein two adjacent electricity of any one magnet coil (1) just to another row of a row
Between magnetic coil (1).
3. the magnetic control system according to claim 1 for genetic test, it is characterised in that:The mixing array (101)
In each magnet coil (1) be sequentially completed make and break process clockwise or counterclockwise, and repeatedly circulation.
4. the magnetic control system according to claim 1 for genetic test, it is characterised in that:The dragging array (102)
In each magnet coil (1) mixing after array (101) completes work, from close to mixing one end of array (101) to another
End is sequentially completed make and break process.
5. the magnetic control system according to claim 1 for genetic test, it is characterised in that:The dragging array (102)
In each magnet coil (1) mixing after array (101) completes work, from close to mixing one end of array (101) to another
End by it is two neighboring be one group in the way of, be sequentially completed make and break process.
6. the magnetic control system according to claim 2 for genetic test, it is characterised in that:It is described to state dragging array
(102) each magnet coil (1) in is being mixed after array (101) completes work, from close to mix one end of array (101) to
The other end by it is two neighboring or three be one group in the way of, be sequentially completed make and break process；Magnet coil (1) bag of each of which group
Include wherein one row in a magnet coil (1) and another row in its one or two immediate magnet coil (1).
7. the magnetic control system according to claim 1 for genetic test, it is characterised in that:The mixing array (102)
In, the magnetic core of magnet coil (1) is formed by 3 0.65mm*4mm*60mm silicon steel sheet close-packed arrays, and 6 layers are full of outside magnetic core
Line footpath is 0.25mm enamel-covered wire；Dragging array (102) magnetic core is closely arranged by 3 0.65mm*6mm*60mm silicon steel sheet
Row are formed；The enamel-covered wire that 6 layer line footpaths are 0.25mm is full of outside magnetic core.
8. the magnetic control system according to claim 7 for genetic test, it is characterised in that:Mix in array (101)
Magnet coil break-make interval is adjustable, controls in 15ms to 500ms.
9. the magnetic control system according to claim 8 for genetic test, it is characterised in that:Mix in array (101)
Magnet coil break-make Separation control is in 35ms to 65ms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710428548.XA CN107043700B (en) | 2017-06-08 | 2017-06-08 | Control method of magnetic control system for gene detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710428548.XA CN107043700B (en) | 2017-06-08 | 2017-06-08 | Control method of magnetic control system for gene detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107043700A true CN107043700A (en) | 2017-08-15 |
| CN107043700B CN107043700B (en) | 2023-11-24 |
Family
ID=59545971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710428548.XA Active CN107043700B (en) | 2017-06-08 | 2017-06-08 | Control method of magnetic control system for gene detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107043700B (en) |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647020A (en) * | 1991-11-26 | 1994-02-22 | Hitachi Ltd | Probe for nuclear magnetic resonance system |
| JPH10295662A (en) * | 1997-04-24 | 1998-11-10 | Toshiba Corp | Organism magnetic field measuring device |
| JP2000263836A (en) * | 1999-03-19 | 2000-09-26 | Ricoh Co Ltd | Magnetic micro head array |
| US20020013526A1 (en) * | 1999-09-30 | 2002-01-31 | Toshiba America Mri, Inc. | Inherently de-coupled sandwiched solenoidal array coil |
| US6636757B1 (en) * | 2001-06-04 | 2003-10-21 | Surgical Navigation Technologies, Inc. | Method and apparatus for electromagnetic navigation of a surgical probe near a metal object |
| US20050007228A1 (en) * | 2002-09-26 | 2005-01-13 | Wright Andrew M. | High intensity radial field magnetic array and actuator |
| US20050200213A1 (en) * | 2004-03-12 | 2005-09-15 | Kesatoshi Takeuchi | Motor and drive control system thereof |
| US20050284817A1 (en) * | 2003-03-08 | 2005-12-29 | Victor Fernandez | Magnetic bead manipulation and transport device |
| CN103820304A (en) * | 2014-02-25 | 2014-05-28 | 苏州天隆生物科技有限公司 | Microfluid three-dimensional electromagnetic excitation blending device for nucleic acid purification |
| CN103995052A (en) * | 2014-05-22 | 2014-08-20 | 西安交通大学 | Small diameter tube structure electromagnetic ultrasonic non-destructive detection method based on rotating magnetic field |
| CN104007180A (en) * | 2014-05-20 | 2014-08-27 | 北京工业大学 | Torsional mode magnetostriction sensor array |
| CN104774761A (en) * | 2015-03-04 | 2015-07-15 | 江苏大学 | Magnetic bead driving method and apparatus allowing cells to do rectilinear motion in micro-fluidic chip |
| CN105112499A (en) * | 2015-06-16 | 2015-12-02 | 广州燃石医学检验所有限公司 | Method for enriching target regions of 168 genes based on multi-probes |
| CN105349530A (en) * | 2015-12-11 | 2016-02-24 | 杭州优思达生物技术有限公司 | New type nucleic acid detection method and detector tube |
| CN105441321A (en) * | 2015-12-11 | 2016-03-30 | 杭州优思达生物技术有限公司 | Automatic integrated nucleic acid analyzer |
| CN106329677A (en) * | 2015-06-23 | 2017-01-11 | 刘跃进 | Switch array-type position induction focusing technology for wirelessly charging electric vehicle |
| CN206783685U (en) * | 2017-06-08 | 2017-12-22 | 杭州遂真生物技术有限公司 | Magnetic control system for genetic test |
-
2017
- 2017-06-08 CN CN201710428548.XA patent/CN107043700B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647020A (en) * | 1991-11-26 | 1994-02-22 | Hitachi Ltd | Probe for nuclear magnetic resonance system |
| JPH10295662A (en) * | 1997-04-24 | 1998-11-10 | Toshiba Corp | Organism magnetic field measuring device |
| JP2000263836A (en) * | 1999-03-19 | 2000-09-26 | Ricoh Co Ltd | Magnetic micro head array |
| US20020013526A1 (en) * | 1999-09-30 | 2002-01-31 | Toshiba America Mri, Inc. | Inherently de-coupled sandwiched solenoidal array coil |
| US6636757B1 (en) * | 2001-06-04 | 2003-10-21 | Surgical Navigation Technologies, Inc. | Method and apparatus for electromagnetic navigation of a surgical probe near a metal object |
| US20050007228A1 (en) * | 2002-09-26 | 2005-01-13 | Wright Andrew M. | High intensity radial field magnetic array and actuator |
| US20050284817A1 (en) * | 2003-03-08 | 2005-12-29 | Victor Fernandez | Magnetic bead manipulation and transport device |
| US20050200213A1 (en) * | 2004-03-12 | 2005-09-15 | Kesatoshi Takeuchi | Motor and drive control system thereof |
| CN103820304A (en) * | 2014-02-25 | 2014-05-28 | 苏州天隆生物科技有限公司 | Microfluid three-dimensional electromagnetic excitation blending device for nucleic acid purification |
| CN104007180A (en) * | 2014-05-20 | 2014-08-27 | 北京工业大学 | Torsional mode magnetostriction sensor array |
| CN103995052A (en) * | 2014-05-22 | 2014-08-20 | 西安交通大学 | Small diameter tube structure electromagnetic ultrasonic non-destructive detection method based on rotating magnetic field |
| CN104774761A (en) * | 2015-03-04 | 2015-07-15 | 江苏大学 | Magnetic bead driving method and apparatus allowing cells to do rectilinear motion in micro-fluidic chip |
| CN105112499A (en) * | 2015-06-16 | 2015-12-02 | 广州燃石医学检验所有限公司 | Method for enriching target regions of 168 genes based on multi-probes |
| CN106329677A (en) * | 2015-06-23 | 2017-01-11 | 刘跃进 | Switch array-type position induction focusing technology for wirelessly charging electric vehicle |
| CN105349530A (en) * | 2015-12-11 | 2016-02-24 | 杭州优思达生物技术有限公司 | New type nucleic acid detection method and detector tube |
| CN105441321A (en) * | 2015-12-11 | 2016-03-30 | 杭州优思达生物技术有限公司 | Automatic integrated nucleic acid analyzer |
| CN206783685U (en) * | 2017-06-08 | 2017-12-22 | 杭州遂真生物技术有限公司 | Magnetic control system for genetic test |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107043700B (en) | 2023-11-24 |
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