CN107041799A - The micro pressure sensing device of sacculus radial expansion force can be measured in real time - Google Patents
The micro pressure sensing device of sacculus radial expansion force can be measured in real time Download PDFInfo
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- CN107041799A CN107041799A CN201710069094.1A CN201710069094A CN107041799A CN 107041799 A CN107041799 A CN 107041799A CN 201710069094 A CN201710069094 A CN 201710069094A CN 107041799 A CN107041799 A CN 107041799A
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- 239000013307 optical fiber Substances 0.000 claims description 12
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- 238000001727 in vivo Methods 0.000 claims description 4
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- 239000000203 mixture Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 abstract description 4
- 230000000916 dilatatory effect Effects 0.000 abstract description 2
- 210000003709 heart valve Anatomy 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/243—Deployment by mechanical expansion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/243—Deployment by mechanical expansion
- A61F2/2433—Deployment by mechanical expansion using balloon catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2472—Devices for testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L1/00—Measuring force or stress, in general
- G01L1/24—Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis using infrared, visible light, ultraviolet
- G01L1/242—Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis using infrared, visible light, ultraviolet the material being an optical fibre
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Measuring Fluid Pressure (AREA)
Abstract
The invention discloses the micro pressure sensing device that can measure sacculus radial expansion force in real time.The sacculus outer wall of sacculus dilating catheter is provided with micro pressure sensor at implantation cardiac valves.By the induction installation of sensor, the deformation of sacculus can be converted to the parameter of pressure output to be included on the electronic curtain at handle, and being implanted into balloon-expandable valve to clinical simulation heart provides parameter foundation.
Description
Technical field
The invention belongs to technical field of medical instruments, the micro pressure sensing of sacculus radial expansion force can be measured in real time by being related to
Device.
Background technology：
In heart balloon expandable valve implantation process, the sacculus that doctor will be observed under low pressure fills situation, and to judge
Whether sacculus is in diseased region.If narrow " dog bone " phenomenon caused appears precisely at sacculus middle, need to continue
Phenomenon disappearance is pressurized to, sacculus is opened completely.If sacculus does not expand adherent completely, thrombus and subacute stent thrombosis shape can be caused
Into.Thus the real-time parameter monitoring in implantation process is highly desirable to.
Parameter measurement is carried out in vivo, and ripe system is SmartPill companies of the U.S. in a new generation of production in 2005
The noninvasive painless inspection system of intestines and stomach --- miniature electronic capsule, and have passed through the certification of FDA (Food and Drug Adminstration).Should
Temperature, pressure and pH value under the measurable human gastrointestinal tract normal physiological condition of product.Shanghai Communications University is same in 2008
It has developed multiparameter telemetry capsule.Technique is more ripe in intestines and stomach are detected, and can be introduced into heart and do same spy
Look into.
The pressure parameter situation of balloon expandable when in the technique, showing cardiac valves implantation.Press in a device
The stability of force snesor is very important.In Cardiac interventional with pressure sensor is installed on sacculus, because of the office in space
Sex-limited, pressure sensor should be miniature, but, it is necessary in the limited space of very little in the manufacturing process of micro pressure sensor
Interior assembling multiple assembly, the component such as the adhesive of pressure sensor will make the performance of pressure sensor be affected.
The present invention relates to a kind of micro pressure sensor, there is very much side for measuring the radial load in balloon expandable state
Help, real-time pressure condition during measurable balloon expandable.
The content of the invention
The present invention, which is provided, can measure the micro pressure sensing device of sacculus radial expansion force in real time.The technology that the present invention is provided
Scheme is as follows：
It is a kind of can real-time testing sacculus radial expansion force micro pressure sensing device, be included in sacculus periphery cladding it is micro-
Type pressure sensor, sensor is followed by wire, in the electronic curtain by wire transmission to handle end, realizes that parameter is exported.
Alternately, the micro pressure sensing device can use miniature optical fibre Fabry-perot pressure sensing
Device is constituted.Structure is made up of optical fiber, flexible sheet, the part of sensor body three.Generally it is made up of fiber optics end face and diaphragm end face
Fabry-Perot micro-resonant cavity, diaphragm deformation will be made when pressure is acted on diaphragm, and make it that Fa-Po cavity length changes,
So as to realize sensing.Conversion parameter is realized in the final circuit board picked out by wire below the electronic curtain of handle part.
Alternately, the micro pressure sensing device can equally be pressed using graphene flexible electronic sensor
Power is detected, and using ductility and the flexibility of grapheme material, is covered on balloon surface, any gap is not produced, accurate in real time to survey
Try to realize conversion ginseng in pressure during balloon expandable, the circuit board finally picked out below the electronic curtain of handle part by wire
Number.
When alternately, using Miniature optical fiber Fabry-Perot pressure sensor, Pyrex glass can be used in sensor
Glass or fused silica material.
When alternately, using flexible electronic sensor, the accurate electrode is circumferentially uniformly distributed along sacculus, is surrounded
In sacculus middle-end.
When alternately, using flexible electronic sensor, conducting nanoparticles aggregate and electrode contact.
When alternately, using flexible electronic sensor, the nano-particle is fitted with flexible material face, accurate to pass
Feel interelectrode distance change two-by-two.
When alternately, using flexible electronic sensor, wire, wire connection are terminated with after the microsensor
In circuit board below the handle screen.
Alternately, the graphene flexible electronic sensor can be existed using counter ion lithographic technique or impact technology
Graphene, the change that detection compression resistance occurs under stress, so as to infer the size of stress are stamped on substrate.
When alternately, using flexible electronic sensor, described printing circuit switching back is provided with pad, weldering
Disk realizes and is connected that the binding line is located at the bottom of printing circuit switching plate with micro pressure sensor chip chamber by binding line.
The advantage and good effect of the present invention：
Sensor of the invention is arranged on sacculus, and sensor exquisiteness does not influence accuracy, passes through internal electronic chip
Voluntarily conversion parameter, gives operation doctor intuitively data reference, while it also avoid that balloon expandable not exclusively brought is concurrent
Disease.
Brief description of the drawings
Fig. 1 is the principle schematic of the optical fiber Fabry-Perot pressure sensor in the present invention.
Fig. 2 is the schematic diagram that sensor in the present invention is covered on sacculus.
Fig. 3 is the top view that sacculus adds microelectrode.
Fig. 4 (a) is the structural representation of flexible electronic sensor in the present invention.
Fig. 4 (b) is the structural representation of another flexible electronic sensor in the present invention.
Fig. 4 (c) is state diagram when balloon interior produces pressure.
Fig. 5 prepares sketch for graphene film.
Fig. 6 is the projection spectrum and Raman spectrum of graphene film.
Reference：100 it is sacculus, 101 be sacculus outer wall, 102 be sacculus inwall, 200 be microsensor, 201 is
Accurate electrode, 202 be conducting nanoparticles aggregate, 203 be measurement apparatus, 204 be first electrode, 205 be second electrode,
206 be flexible substrate.300 it is optical fiber Fabry-Perot pressure sensor system, 301 be optical fiber, 302 be hollow pipe, 303 is
Wire, 304 be printing circuit switching plate, 305 be micro pressure sensor chip, 306 be reinforcing plate for suppressing pressure.
Embodiment
The present invention is further described below in conjunction with accompanying drawing.It will be appreciated that institute's graph plotting type and the explanation that is provided are only
It is that the present invention will be described for example preferably, and should not be construed as constituting protection scope of the present invention and limit
System, protection scope of the present invention is only limited by claims.
The wired sexual intercourse of diaphragm of the pressure and sensor 200, by vitro when measurement draw.Refer to accompanying drawing 6.
The first implementation optical fiber Fabry-Perot pressure sensor 300 when operation principle be：When sacculus 100 is implemented
During expansion, flexible sheet deforms, and drives optical fiber 301 to produce slip, changes the distance between fiber facet and transmission face, leads to
The change of cavity length for extracting sensor is crossed, so as to obtain pressure information.The pressure sensor 300 of Fabry-Perot is with being based on electric capacity
Pressure sensor it is much like, pressure measxurement is completed by the skew of measuring diaphragm.Meanwhile, the pressure sensing of this embodiment
Device 200,300 is considered as the pressure sensor of the optimal potentiality available for a variety of applications, it is adaptable to which the pressure in microminiature space is surveyed
Amount.
In the first implementation optical fiber Fabry-Perot pressure sensor 300, air pressure sensing component is covered on the outside of sacculus
101, with sacculus 100 together enter cardiac replacement valve at, measured in environment in vivo, feedback signal with Fabry-
The change of Perot cavity chamber length and change, the air pressure sensing component is connected by light path converting template with signal demodulation components, by believing
The pressure at air pressure sensing component position is finally inversed by the signal that number demodulation components are exported from air pressure sensing component.
In the first implementation optical fiber Fabry-Perot pressure sensor 300, the thickness of diaphragm can be between 0.05mm-1mm
Between.
In the first implementation optical fiber Fabry-Perot pressure sensor 300, during encapsulating structure, housing can be followed successively by interior
Printing circuit switching plate 304, micro pressure sensor chip 305 and the reinforcing plate 306 for suppressing pressure in portion, miniature pressure
The both sides of force snesor 300 can all do thin, as engraved structure, and the design of this device can increase while sensor performance is increased
The Stability and veracity for having added sensor to measure.
In this embodiment of flexible electrode sensor 200 is used, the device of measurement pressure includes basic sensor
201st, electrode 204,205, the conducting or semiconducting nanoparticle aggregate 202 with reference to electrode.Electrode 204,205 and nanoparticle
Subset zoarium 202 is in contact.Electrode 204,205 is fitted in 206 on flexible bottom surface with the entirety of nanoparticle aggregate 202, flexible
Bottom surface 206 is covered on dilating sacculus outer surface 101.This sensitivity of micro pressure sensor 200 is high, the size of nano-particle 202
Between several nanometers of centres, and tens microns can be reached, the thickness very little of integral pressure sensor 200 is at maximum up to by actual conditions
0.2 millimeter, the expansion of sacculus is not interfered with.
In this embodiment of flexible electrode sensor 200 is used, continuous type sensor includes flexible body, nanometer thereon
Particle assembly body 202 and multiple electrodes 204,205.When external force of the nanoparticle aggregate 202 by outer Force system, measurement
The electrical characteristics of nanoparticle aggregate 202 change, and are combined according to the Different electrodes between two groups, test out electrode two-by-two
Relevant parameter, it may be determined that change curve of the electrical characteristics on aggregate whole surface, can be measured according to electrical property change afterwards
The internal pressure information of measured body.
In this embodiment of flexible electrode sensor 200 is used, when the internal mechanical force of sacculus 100 acts on nano-particle
During aggregate 202, the distance between all or part of nano-particles of aggregate change, so that the electricity for changing aggregate is special
Property.The intensity of mechanical force can be determined by measuring sensitive electrical characteristics of adjusting the distance.The mechanical force of balloon interior 102 can be to put on this hair
Power, pressure or the deformation of improving eyesight device for mark.Finally be in contact with sacculus outer wall 101 for flexible material.
In using flexible electrode sensor 200 this embodiment, continuous type sensor arrangement 101 on the outside of sacculus, with
101 contact on the outside of sacculus.This sensor 200 allows using flexible material bottom sacculus hurtless measure, the sensitivity of sensor 200
Face, such a material will not hinder the flowing of blood, and the test of short time in vivo will not cause any discomfort.
The switching back of printed circuit 304 described in above-mentioned micro pressure sensor 200 is provided with pad, pad and miniature pressure
Connected between sensor chip 305 by binding line.
Above-mentioned pressure sensor 200,300 is suitable for signal real-time Transmission and observed for a long time.
Embodiments of the present invention are described in detail above in conjunction with accompanying drawing, but the invention is not restricted to above-mentioned implementation
Mode, in the knowledge that art those of ordinary skill possesses, can also not depart from present inventive concept
Under the premise of make a variety of changes.
Claims (10)
1. the micro pressure sensing device of sacculus radial expansion force can be measured in real time, it is characterised in that be covered with sacculus periphery
Micro pressure sensor, sensor is followed by wire, is changed in the circuit board by wire transmission to handle end, is shown in electricity
Sub-screen, realizes that parameter is exported.
2. micro pressure sensor device according to claim 1, it is characterised in that miniature Fiber Optic Sensor cloth can be used
In-Perot pressure sensor composition.Structure is made up of optical fiber, flexible sheet, the part of sensor body three.Generally by fiber optics end face
Fabry-Perot micro-resonant cavity is constituted with diaphragm end face, diaphragm deformation will be made when pressure is acted on diaphragm, and makes amber of doing in the proper way
Chamber length changes, so as to realize sensing.It is real in the final circuit board picked out by wire below the electronic curtain of handle part
Existing conversion parameter.
3. micro pressure sensor device according to claim 1, it is characterised in that can equally use graphene flexible electrical
Sub- sensor carries out pressure detection, using ductility and the flexibility of grapheme material, is covered on balloon surface, any is not produced
Gap, pressure during accurate test balloon expandable, is finally picked out the circuit below the electronic curtain of handle part by wire in real time
Conversion parameter is realized in plate.
4. micro pressure sensor device according to claim 1, it is characterised in that Pyrex glass can be used in sensor
Or fused silica material.
5. micro pressure sensor device according to claim 1, it is characterised in that air pressure sensing component is covered on sacculus
Outside, enters at cardiac replacement valve, is measured in environment in vivo, feedback signal is with Fabry-Perot together with sacculus
The change of sieve chamber chamber length and change, the air pressure sensing component is connected by light path converting template with signal demodulation components, by signal
The pressure at air pressure sensing component position is finally inversed by the signal that demodulation components are exported from air pressure sensing component.
6. micro pressure sensing device according to claim 3, it is characterised in that the accurate electrode is circumferentially equal along sacculus
Even distribution, is centered around sacculus middle-end.
7. micro pressure sensing device according to claim 3, it is characterised in that conducting nanoparticles aggregate and electrode
Contact.
8. micro pressure sensing device according to claim 3, it is characterised in that the nano-particle and flexible material face
Laminating, accurately senses interelectrode distance change two-by-two.
9. micro pressure sensing device according to claim 3, it is characterised in that be terminated with leading after the microsensor
Line, wire is connected in the circuit board below handle screen.
10. micro pressure sensing device according to claim 3, it is characterised in that the graphene flexible electronic sensing
Device can stamp graphene using counter ion lithographic technique or impact technology on substrate, and detection compression resistance is issued in stress
Raw change, so as to infer the size of stress.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710069094.1A CN107041799A (en) | 2017-02-08 | 2017-02-08 | The micro pressure sensing device of sacculus radial expansion force can be measured in real time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710069094.1A CN107041799A (en) | 2017-02-08 | 2017-02-08 | The micro pressure sensing device of sacculus radial expansion force can be measured in real time |
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| Publication Number | Publication Date |
|---|---|
| CN107041799A true CN107041799A (en) | 2017-08-15 |
Family
ID=59544513
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710069094.1A Pending CN107041799A (en) | 2017-02-08 | 2017-02-08 | The micro pressure sensing device of sacculus radial expansion force can be measured in real time |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485466A (en) * | 2017-09-21 | 2017-12-19 | 铜仁市恒睿生产力促进中心有限公司 | A kind of local deformation expands formula catheter sheath and intervention apparatus conveying device |
| CN107870052A (en) * | 2017-10-20 | 2018-04-03 | 重庆大学 | A kind of mini optical fibre method amber pressure sensor |
| CN108626104A (en) * | 2018-06-22 | 2018-10-09 | 佛山科学技术学院 | A kind of anti-evacuator |
| CN108827791A (en) * | 2018-04-28 | 2018-11-16 | 河南威浦仕医疗科技有限公司 | Foley's tube preload pressure test device |
| CN111198063A (en) * | 2018-11-16 | 2020-05-26 | 北京纳米能源与系统研究所 | Pressure sensor |
| WO2020143091A1 (en) * | 2019-01-07 | 2020-07-16 | 大连理工大学 | Multi-cavity superimposed non-resonant photoacoustic cell and gas detection system |
| CN111870397A (en) * | 2020-08-30 | 2020-11-03 | 吉林大学 | Bionic artificial valve anticoagulation performance testing device based on in-situ monitoring |
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| CN103566461A (en) * | 2012-08-08 | 2014-02-12 | 上海微创医疗器械（集团）有限公司 | Balloon filling device |
| CN103877656A (en) * | 2014-04-09 | 2014-06-25 | 济南市第四人民医院 | Laryngeal mask, manufacturing method for same and tube inserting method for same |
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| CN104644294A (en) * | 2015-03-20 | 2015-05-27 | 河南科技大学第一附属医院 | Nasal cavity nursing rack for burnt patient |
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| US20090287118A1 (en) * | 2008-05-15 | 2009-11-19 | Malek Michel H | Functional discography catheter |
| CN101832832A (en) * | 2010-05-28 | 2010-09-15 | 天津大学 | Optical fiber Fabry-Perot pressure sensor and production method thereof |
| CN103229034A (en) * | 2010-11-24 | 2013-07-31 | 纳米制造概念公司 | Miniaturized pressure sensor |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485466A (en) * | 2017-09-21 | 2017-12-19 | 铜仁市恒睿生产力促进中心有限公司 | A kind of local deformation expands formula catheter sheath and intervention apparatus conveying device |
| CN107870052A (en) * | 2017-10-20 | 2018-04-03 | 重庆大学 | A kind of mini optical fibre method amber pressure sensor |
| CN108827791A (en) * | 2018-04-28 | 2018-11-16 | 河南威浦仕医疗科技有限公司 | Foley's tube preload pressure test device |
| CN108827791B (en) * | 2018-04-28 | 2020-10-02 | 河南威浦仕医疗科技有限公司 | Sacculus pipe pre-compaction pressure testing arrangement |
| CN108626104A (en) * | 2018-06-22 | 2018-10-09 | 佛山科学技术学院 | A kind of anti-evacuator |
| CN108626104B (en) * | 2018-06-22 | 2024-04-30 | 佛山科学技术学院 | Evacuating-proof device |
| CN111198063A (en) * | 2018-11-16 | 2020-05-26 | 北京纳米能源与系统研究所 | Pressure sensor |
| WO2020143091A1 (en) * | 2019-01-07 | 2020-07-16 | 大连理工大学 | Multi-cavity superimposed non-resonant photoacoustic cell and gas detection system |
| CN111870397A (en) * | 2020-08-30 | 2020-11-03 | 吉林大学 | Bionic artificial valve anticoagulation performance testing device based on in-situ monitoring |
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