CN107029160A - It is a kind of that there is heat-clearing and damp-drying drug, pharmaceutical composition of the antipruritic function of desinsection and preparation method thereof - Google Patents
It is a kind of that there is heat-clearing and damp-drying drug, pharmaceutical composition of the antipruritic function of desinsection and preparation method thereof Download PDFInfo
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- CN107029160A CN107029160A CN201710448956.1A CN201710448956A CN107029160A CN 107029160 A CN107029160 A CN 107029160A CN 201710448956 A CN201710448956 A CN 201710448956A CN 107029160 A CN107029160 A CN 107029160A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- Gynecology & Obstetrics (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
There is heat-clearing and damp-drying drug, the pharmaceutical composition of the antipruritic function of desinsection the invention provides a kind of, it is by being prepared from comprising the bulk drug that following weight is matched：16 24 parts of kuh-seng, 12 18 parts of the root bark of shaggy-fruited dittany, 8 12 parts of frutus cnidii, 12 18 parts of the tuber of stemona, 46 parts of cicada slough, 21 39 parts of dandelion.Present invention also offers the preparation method of said composition and purposes.The composition that the present invention is provided, rationally, it is damp and hot to can be used for treatment pruitus, private parts, and a kind of new medicament selection is provided for clinic for compatibility.
Description
Technical field
The invention belongs to drug field, be related to it is a kind of have heat-clearing and damp-drying drug, the pharmaceutical composition of the antipruritic function of desinsection and its
Preparation method and purposes.
Background technology
Urinary tract infections refers to pathogen growth and breeding in urinary tract, and invades scorching caused by uropoiesis mucous membrane or tissue
Disease, is most common a kind of infection in bacterium infection.Fracture, cerebral infarction, etc. Cerebral Hemorrhage Disease can make patient's long-term bed.In length
It is uncomfortable to urinate in bed during phase bed, the retention of urine will be caused, indwelling catheter can play mitigation patient's pain if necessary
Bitter effect.But as store period, indwelling catheter can cause urinary infection, easily cause urinary tract infections, perineum
The phenomenons such as eczema, peculiar smell, had not only extended the hospital stays but also had added patient's hospitalization cost and pain.
In order to promote patient can rehabilitation as early as possible, it is particularly significant to the perineum care of patient bedridden in long term.Present most of doctors
Chief minister carries out perineum care with Iodophor.But Iodophor is the instability mode product that iodine is combined with surfactant, because of its knot
Close unstable, gradually discharge free-iodine after contact skin or mucous membrane and play sterilization, its Disinfection Effect is by skin
The influence of many factors such as skin mucous membrane surface organic matter, acid-base value, surface adsorbate, the situation of generation is not infected in urethral orifice
Under, artificial disturbance is carried out using disinfectant, the presence of skin and mucosa normal flora is not only have impact on, and be unfavorable for itself anti-sense
The maintenance of dye factor.In addition there is iodine allergy phenomenon by skin and mucosa absorbed into serum in the free-iodine discharged.Therefore,
Need to further develop can use safely, perineum care medicine evident in efficacy.
The content of the invention
There is heat-clearing and damp-drying drug, the pharmaceutical composition of the antipruritic function of desinsection and its preparation it is an object of the invention to provide a kind of
Method and purposes.
There is heat-clearing and damp-drying drug, the pharmaceutical composition of the antipruritic function of desinsection the invention provides a kind of, it is by comprising following
The bulk drug of weight proportion is prepared from：
16-24 parts of kuh-seng, 12-18 parts of the root bark of shaggy-fruited dittany, 8-12 parts of frutus cnidii, 12-18 parts of the tuber of stemona, 4-6 parts of cicada slough, dandelion
21-39 parts.
Wherein, it is that the raw material matched by following weight is prepared from：
20 parts of kuh-seng, 15 parts of the root bark of shaggy-fruited dittany, 10 parts of frutus cnidii, 15 parts of the tuber of stemona, 5 parts of cicada slough, 30 parts of dandelion.
Wherein, it be by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii, the tuber of stemona, cicada slough, dandelion primary powder or water or organic solvent
Extract is active component, adds the preparation that pharmaceutically acceptable auxiliary material or complementary composition are prepared from.
Wherein, the preparation is external preparation.
Wherein, the external preparation is liniment, decoction, paste, tincture gel, lotion, aerosol or spray.
Present invention also offers the preparation method of above-mentioned composition, it comprises the following steps：
A, the raw material for weighing each weight proportion；
B, raw material directly beaten to powder, or add water or after organic solvent extracts, add pharmaceutically acceptable auxiliary material or auxiliary
Property composition is prepared from.
Present invention also offers use of the above-mentioned composition in preparing with heat-clearing and damp-drying drug, the medicine of the antipruritic function of desinsection
On the way.
Wherein, the medicine is treatment pruitus, damp and hot private parts, eczema, the medicine of allergy.
Wherein, the medicine is the medicine for perineum care.
Further, the medicine is to mitigate perineum peculiar smell, prevent the medicine of urinary tract infections.
The composition that the present invention is provided, rationally, kuh-seng in side is bitter, trembles with fear, heat-clearing and damp-drying drug, and purging intense heat and detonicating is monarch drug in a prescription for compatibility.
Root bark of shaggy-fruited dittany heat-clearing and damp-drying drug, dispelling wind and arresting itching is ministerial drug.Tuber of stemona external application desinsection and delousion, frutus cnidii external application removing dampness and destroying parasites is antipruritic, dandelion
It is clearing heat and detoxicating, dispersing swelling and dissipating binds, eliminating dampness and heat is altogether adjutant, to help the power that monarch, ministerial drug heat-clearing and damp-drying drug, desinsection are antipruritic.Peppermint is pungent,
It is cool, tourette production of aromatic, dispelling wind and heat from the body, to make medicine, above all medicines share plays the antipruritic work(of heat-clearing and damp-drying drug, desinsection, skin can be used for outside altogether
Skin itch, private parts is damp and hot to wait disease；It is easy to use and present composition security is good, has no toxic side effect, provided for clinic
A kind of new medicament selection.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification of other diversified forms can also be made, replaces or changes.
The embodiment of form, remakes further specifically to the above of the invention by the following examples
It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
It is described further below with embodiment, but the present invention is not limited to these embodiments.
The preparation of the present composition of embodiment 1
Prescription：Kuh-seng 20g, root bark of shaggy-fruited dittany 15g, frutus cnidii 10g, tuber of stemona 15g, cicada slough 5g, dandelion 30g.
Preparation method：Above medicine is weighed, is added water to cook 2 times, 30 minutes after the 1st boiling, 20 points after the 2nd boiling
Clock.Collecting decoction, filtering, is concentrated into 250ml.Concentrate adds preservative sodium benzoate and is uniformly mixed, filling, 250ml/
Bottle, labeling is produced.
Usage and consumption：Take this product appropriate, at outer wiping skin or pudendal pruritus, 2-3 times on the one；Also it can use this product 20-
40ml warm waters are rinsed or hip bath to 1000-2000ml.
The preparation of the present composition of embodiment 2
Prescription：Kuh-seng 16g, root bark of shaggy-fruited dittany 12g, frutus cnidii 8g, tuber of stemona 12g, cicada slough 6g, dandelion 39g.
Preparation technology：The preparation technology of be the same as Example 1.
The preparation of the present composition of embodiment 3
Prescription：Kuh-seng 24g, root bark of shaggy-fruited dittany 18g, frutus cnidii 12g, tuber of stemona 18g, cicada slough 4g, dandelion 21g.
Preparation technology：The preparation technology of be the same as Example 1.
The preparation of the present composition of embodiment 4
Prescription：The prescription of be the same as Example 1.
Preparation technology：Each bulk drug is weighed by prescription, is crushed, is sieved, is mixed, is dispensed, sterilizing is produced.
Illustrate beneficial effects of the present invention with the mode of test example below：
Effect of the present composition of test example 1 in Therapy of Elder Hip Fracture indwelling catheter patient's perineum care
1 data and method
1.1 clinical data
Choose and treat Therapy of Elder Hip Fracture indwelling catheter trouble in July, -2016 in January, 2014 in section of the Nanchong City hospital of traditional Chinese hospital
Person 60, is randomly divided into two groups.Observation group 30, wherein male 10, female 20, age 60-90 Sui, average age 70.5
Year.Control group 30, wherein man 12, female 18, age 61-92 Sui, average age 73.4 years old.Two groups before the study without meeting
Pudendum disease history and urinary tract infections, indwelling catheter is the double-cavity balloon catheter of same producer, and male using model 16,
Women is No. 18-20, is compared in terms of two groups of Genders, age, the state of an illness, social backgrounds, the not statistically significant (P of difference
＞ 0.05), with comparativity.
1.2 method
1.2.1 observation group
Nursed using conventional meanses, (inspection that the placement situation i.e. to patient's urinal and urinary catheter is timed is protected
The placing height for demonstrate,proving urinal is less than pubic symphysis, changes urine collection bag with Thursday on every Mondays) add pharmaceutical composition of the present invention to enter guild
The moon nursing, carries out 2 perineum cares daily.Care method：Patient makes even clinostatism, single, kidney basin during stern underlay is disposable, with sterile
The pharmaceutical composition 50ml that gynaecology's cotton swab picks the preparation of the method for the embodiment of the present invention 1 is wiped, female patient scouring urethral orifice,
Vulva and groin；Male patient cleans urethral orifice, glans penis, foreskin and scrotum.
1.2.2 control group
Nursed using conventional meanses, (inspection that the placement situation i.e. to patient's urinal and urinary catheter is timed is protected
The placing height for demonstrate,proving urinal is less than pubic symphysis, changes urine collection bag with Thursday on every Mondays) plus 0.5% Iodophor progress perineum care,
2 times a day.Two groups of operating methods are identical, all strictly carry out, entered by the nurse Jing Guo professional training by aseptic technique principle
Row operation, from top to bottom, cleans perineum from inside to outside.
1.3 evaluation method
Effect assessment is carried out after intervening 7d.Main detection evaluates two groups of Urinary cultivation results, perineal skin and peculiar smell
Situation.Strict implement sterile working principle during preserving urine sample, urine is pollution-free, strictly enters by clinical examination operation requirement
OK；Perineum peculiar smell：Scoring uses Organoleptic methodThe ﹞ of ﹝ 3, 0=odorlessnesses, 1=is difficult to smell smell, and 2=smells slight displeased
Fast smell, 3=smells the unhappy smell of moderate, and 4=smells strong sharp aroma；Perineal skin：The skin of perineum whether there is
The generation of eczema, perineal skin whether there is allergic phenomena appearance.
1.4 statistical method
Statistical analysis is carried out using statistics software SPSS 13.0, enumeration data uses chi-square criterion, and ranked data use order
And inspection.It is that difference is statistically significant with P ＜ 0.05.
Every observation index compares (example) after 1 two groups of interventions of table
2 results
From table 1, observation group's Urinary positive, skin eczema, allergy and perineum peculiar smell occur number of cases and are significantly lower than
Control group, difference has statistical significance (P ＜ 0.05).
Illustrate that pharmaceutical composition of the present invention is good to Therapy of Elder Hip Fracture indwelling catheter patient's perineum care effect, can effectively drop
The incidence of low urinary tract infections, perineum eczema and allergy, improves perineum bad smell and to skin without pessimal stimulation, effect
It is significantly better than thimerosal Iodophor.
In summary, present composition compatibility rationally, to pruitus, private parts is damp and hot wait disease have good treatment and
Adjuvant treatment effect, it is especially good to perineum care effect；And present composition security is good, has no toxic side effect, user
Just, a kind of new medicament selection is provided for clinic.
Claims (10)
1. a kind of have heat-clearing and damp-drying drug, the pharmaceutical composition of the antipruritic function of desinsection, it is characterised in that：It is by comprising following weight
The bulk drug of proportioning is prepared from：
16-24 parts of kuh-seng, 12-18 parts of the root bark of shaggy-fruited dittany, 8-12 parts of frutus cnidii, 12-18 parts of the tuber of stemona, 4-6 parts of cicada slough, dandelion 21-39
Part.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is the raw material matched by following weight prepare and
Into：
20 parts of kuh-seng, 15 parts of the root bark of shaggy-fruited dittany, 10 parts of frutus cnidii, 15 parts of the tuber of stemona, 5 parts of cicada slough, 30 parts of dandelion.
3. composition according to claim 1 or 2, it is characterised in that：It is by kuh-seng, the root bark of shaggy-fruited dittany, frutus cnidii, the tuber of stemona,
Cicada slough, the primary powder of dandelion or water or extractive with organic solvent are active component, add pharmaceutically acceptable auxiliary material or auxiliary
The preparation that helping property composition is prepared from.
4. composition according to claim 3, it is characterised in that：The preparation is external preparation.
5. composition according to claim 4, it is characterised in that：The external preparation is liniment, decoction, paste, tincture
Gel, lotion, aerosol or spray.
6. the preparation method of composition described in claim 1-5 any one, it is characterised in that：It comprises the following steps：
A, the raw material for weighing each weight proportion；
B, raw material directly beaten to powder, or added water or after organic solvent extracts, add pharmaceutically acceptable auxiliary material or it is complementary into
Divide and be prepared from.
7. the composition described in claim 1-5 any one is in preparing with heat-clearing and damp-drying drug, the medicine of the antipruritic function of desinsection
Purposes.
8. purposes according to claim 7, it is characterised in that：The medicine is damp and hot, wet for treatment pruitus, private parts
The medicine of rash, allergy.
9. purposes according to claim 7, it is characterised in that：The medicine is the medicine for perineum care.
10. purposes according to claim 9, it is characterised in that：The medicine is mitigation perineum peculiar smell, prevention urinary tract sense
The medicine of dye.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710448956.1A CN107029160A (en) | 2017-06-14 | 2017-06-14 | It is a kind of that there is heat-clearing and damp-drying drug, pharmaceutical composition of the antipruritic function of desinsection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710448956.1A CN107029160A (en) | 2017-06-14 | 2017-06-14 | It is a kind of that there is heat-clearing and damp-drying drug, pharmaceutical composition of the antipruritic function of desinsection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107029160A true CN107029160A (en) | 2017-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710448956.1A Pending CN107029160A (en) | 2017-06-14 | 2017-06-14 | It is a kind of that there is heat-clearing and damp-drying drug, pharmaceutical composition of the antipruritic function of desinsection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244347A (en) * | 2021-06-30 | 2021-08-13 | 张国华 | A topical cream for the treatment of dermatoses |
-
2017
- 2017-06-14 CN CN201710448956.1A patent/CN107029160A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 刘忠强等: ""中医治疗老年性阴道炎60例"", 《中国民间疗法》 * |
| 张文英等: ""中西医综合治疗外阴硬化性苔癣120例"", 《陕西中医》 * |
| 张道诚: ""苦蝉煎外洗治疗小儿包皮龟头炎"", 《新中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244347A (en) * | 2021-06-30 | 2021-08-13 | 张国华 | A topical cream for the treatment of dermatoses |
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