CN107019853B - The phased method of the Signal averaging of high strength supersonic focus focal regions - Google Patents
The phased method of the Signal averaging of high strength supersonic focus focal regions Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000012935 Averaging Methods 0.000 title claims abstract description 17
- 238000005086 pumping Methods 0.000 claims abstract description 22
- 230000005284 excitation Effects 0.000 claims abstract description 13
- 230000001105 regulatory effect Effects 0.000 claims abstract description 7
- 238000012216 screening Methods 0.000 claims abstract description 3
- 230000001960 triggered effect Effects 0.000 claims description 4
- 238000002679 ablation Methods 0.000 abstract description 10
- 230000001276 controlling effect Effects 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 5
- 210000005013 brain tissue Anatomy 0.000 description 5
- 238000004088 simulation Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 241001522296 Erithacus rubecula Species 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 210000003625 skull Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
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- 206010060862 Prostate cancer Diseases 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000008232 de-aerated water Substances 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
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- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000011125 single therapy Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
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Abstract
The invention discloses a kind of phased methods of Signal averaging of high strength supersonic focus focal regions, comprising the following steps: S1: sine wave point sound source being arranged at focus objects F1, the pumping signal for focusing on F1 is obtained based on time reversal；S2: with the focus objects F2 of F1 distance L at sine wave point sound source is set, obtain and focus on pumping signal at F2；S3: it realizes under conditions of guaranteeing that energy is constant when focusing with single focus and is focused at F1, F2 simultaneously；S4: the value for changing △ t in one cycle is focused, screening melt as a focal regions and temperature field close to platform-type distribution △ t；S5: under the premise of total input energy is constant, regulating and controlling excitation signal amplitude using two temperature maximums at goal-focus F1, F2, is focused according to the pumping signal that gained Amplitude Ration readjusts transducer array element.The present invention can be achieved through cranium focus temperature field to be in platform-type distribution, while focal regions size can be changed, and improve ablation factor.
Description
Technical field
The present invention relates to ultrasonic treatment, the phased method of Signal averaging of specifically a kind of high strength supersonic focus focal regions.
Background technique
High intensity focused ultrasound (High Intensity Focused Ultrasound, HIFU) is as a kind of emerging
Oncotherapy means go deep into human body deep soft tissue and repeatable the advantages that treating by extensive with its Noninvasive, energy
Concern, has been applied to the clinical treatment of the entity tumors such as breast cancer, fibroid, prostate cancer at present.For HIFU brain tumor
For treatment, although the big opening hemispherical phased transducer developed in recent years becomes possibility, the control of temperature and control
The clinical problems such as time length are treated not yet to solve.If the excessively high capillary dilation rupture initiation brain that may cause of brain temperature goes out
Blood；And temperature is relatively low that therapeutic purposes are not achieved；Intracranial tumors size, shape, position vary with each individual, therefore only rely on single simultaneously
The focal regions multiple stacking of ellipsoid shape treats these tumours and is possible to damage brain normal tissue or remains tumor tissues, together
When treatment time it is too long；Though single therapy focal regions volume, shortening can be increased by extending irradiation time or increasing the input sound intensity
Treatment time, but may or the input sound intensity too long because of irradiation time to cross the center temperature rise of ambassador's focal regions excessively high, there is local organization mistake
Heat causes tissue bleeding.
Hynynen in 1984 etc. carries out the irradiation of single multifocal using phased transducer, and proposes the ideal of HIFU Treatment
Focal regions should have uniform dosage distribution in focal regions；Matsumoto in 2012 etc. proposes hot spot elimination algorithm, to a certain degree
On solve the problems, such as spherical crown shape energy converter treatment superficial tumor skull at hot spot deposition；Narumi in 2013 etc. is anti-using the time
Shifting method combination relevant treatment carries out phasing and amplitude compensation to transducer excitation signal, makes ultrasonic energy more effectively
Focus on encephalic target area；The simulation optimizations such as Zhou YF in 2013 irradiation paths, interval exposure make target ablation region
Energy distribution is more evenly.The method that above-mentioned expert proposes is resolved energy deposition problems at skull, however not to controlling
It treats the excessively high possible brain tissue bleeding problems that cause of temperature rise at time length and focal regions and carries out research discussion.In addition, for two excitations
Method also unprecedented research of the signal with respect to the trigger delay time.
Summary of the invention
The present invention is to solve above-mentioned problems of the prior art, provides a kind of letter of high strength supersonic focus focal regions
Number superposition regulation method.
The technical solution used in the present invention is:
A kind of phased method of Signal averaging of high strength supersonic focus focal regions, includes the following steps:
S1: formula (1) S is pressed at focus objects F10(t)=P0Sine wave point sound source is arranged in sin (ω t), anti-based on the time
It is formula (2) that robin, which obtains and focuses on the pumping signal of F1,Wherein,For the excitation of each array element
Signal initial phase, i are array element label, P1Sound pressure amplitude is inputted for energy converter.
S2: with the focus objects F2 of F1 distance L at press formula (1) S0(t)=P0Sinusoidal wave point sound is arranged in sin (ω t)
Source, being obtained based on time reversal and focusing on the pumping signal of F2 is formula (3)Wherein,For each array element pumping signal initial phase, i is array element label, P2Sound pressure amplitude is inputted for energy converter.
S3: under conditions of guaranteeing that energy is constant when focusing with single focus, swash what is obtained when focusing at F1, F2 respectively
It encourages signal and is overlapped while realizing focusing at F1, F2, array element pumping signal is formula (4)Wherein, △ t is S1i(t) relative to S2i(t) delay time triggered.
S4: the value that (0~2 π f) changes △ t in one cycle is focused, wherein f swashs for transducer array element signal
Frequency is encouraged, screening is melted as a focal regions and temperature field is in the △ t of platform-type distribution.
S5: under the premise of guaranteeing that input gross energy is constant, two temperature maximums at goal-focus F1, F2 are utilized
T1、T2Excitation signal amplitude is regulated and controled, is formula (5) S' according to gained Amplitude Ration pumping signal adjustedi(t)=MS1i
(t-△t)+(1-M)S2i(t), wherein regulation coefficient M=k (T2-T1)+b。
The sound intensity is the acoustic energy of unit area, and transducer excitation array element area is not when bifocal point focusing and single focus focus
Become, can will guarantee with single focus focus when energy it is constant be converted into guarantee and single focus focusing when the sound intensity it is constant；When amplitude regulates and controls
Gross energy is set as 1, can will guarantee that constant be converted into of input energy guarantees that the total sound intensity of input is constant.
The available opposite trigger delay time △ t of this method be periodically, and with the transducer excitation signal period one
It causes, therefore available △ t value is not only limited in a cycle, other can also be used under the premise of not influencing focusing effect
Value carries out Temperature Distribution regulation.
The advantages and positive effects of the present invention are:
A. the phased method of Signal averaging of the invention, focusing focal regions temperature field is in platform-type Temperature Distribution, effectively makes ultrasound
Energy distribution is uniform.
B. the focal regions sharpness of border that the present invention is formed after being regulated and controled by the phased method of Signal averaging, and temperature rises and temperature
Declining region has certain spatial gradient, realizes to the temperature control during HIFU Treatment.
C. the phased method of Signal averaging of the invention can adjustment by the opposite trigger delay time to two signals and width
Value regulation realizes the change to focal regions size, and increases single under the premise of energy is constant compared with single focus focuses
Irradiation damage volume.
D. the phased method of Signal averaging of the invention can adjustment by the opposite trigger delay time to two signals and width
Value regulation improves ablation factor under the premise of gross energy is constant, improves HIFU Treatment efficiency compared with single focus focuses,
It can clinically mitigate because for the treatment of time long bring pain and reduce the generation of complication for patient.
Detailed description of the invention
Fig. 1 is two focus objects spatial position schematic diagrames of the invention；
Fig. 2 is the space setting signal that 82 array element random distribution phased transducer of concave spherical surface of the present invention is focused through brain tissue
Figure；
Fig. 3 is the numerical simulation model that 82 array element random distribution phased transducer of concave spherical surface of the present invention is focused through brain tissue
Figure；
Fig. 4 be in the embodiment of the present invention 1 with respect to trigger delay time difference when (0~1400ns) thermo parameters method figure；
Fig. 5 be in the embodiment of the present invention 1 with respect to trigger delay time difference when (0~1400ns) acoustic axis temperature curve
Figure；
When Fig. 6 is opposite trigger delay time difference in the embodiment of the present invention 1 (200~700ns), temperature peak, focal regions
Long axis (direction x), short axle (y, z-axis direction) length with delay time change curve；
Fig. 7 is that L=12.5mm in the embodiment of the present invention 2, Δ t=340ns maximum temperature reach the temperature formed at 65 DEG C
Distribution map；
Fig. 8 is that maximum temperature reaches 65 DEG C and T in the embodiment of the present invention 21、T2Difference be no more than 0.05 DEG C when amplitude
Adjustment factor M curve graph；
Fig. 9 is the temperature profile in the embodiment of the present invention 2 after Energy distribution regulates and controls；
Figure 10 is the phased method flow diagram of Signal averaging of high strength supersonic focus focal regions of the present invention.
Wherein: 1. focus objects F1
2. focus objects F2
3. 82 array element random distribution phased array ultra sound energy converter of concave spherical surface
4. de aerated water
5. brain tissue
6. skull
7. geometrical focus
1. transducer aperture diameter of Φ
2. array element diameter of Φ.
Specific embodiment
Description is described further to technical solution of the present invention below in conjunction with attached drawing and example.
The present invention provides a kind of phased methods of Signal averaging of high strength supersonic focus focal regions.It is anti-that this method is based on the time
Robin focuses focal regions to HIFU using the time delay of array element transmitting signal when adjustment bifocal point focusing and the method for amplitude regulation
Thermo parameters method and focal regions size are regulated and controled.Not only make temperature field in platform-type distribution, focal regions Energy distribution by this method
Uniformly, and focal regions size can be changed, accelerates ablation factor, improves therapeutic efficiency.Fig. 1 is two focus objects spatial positions
Schematic diagram.Fig. 2 is that schematic diagram is arranged in the space of simulation model, and simulation model is out the HIFU Treatment under cranium state.Fig. 3 is numerical value
Simulation model figure is made of energy converter, water and brain tissue, and acoustic axis is x-axis, energy converter be array element spacing not less than 0.7mm with
Machine is distributed 82 array element spherical crown shape phased transducers, wherein opening diameter 100mm, radius of curvature 80mm, array element diameter 8mm, to swash
It is 1W/cm in the input sound intensity for encouraging frequency 0.7MHz2, irradiation time be 6s under conditions of by step implement.
Embodiment 1:
S1: sine wave point sound source S is set at focus objects F1 (65,0,0)0(t)=P0Sin (ω t) is anti-based on the time
Robin, which obtains, to be focused on the pumping signal of F1 and is
S2: sine wave point sound source S is set at the focus objects F2 (75,0,0) with F1 distance L=10mm0(t)=P0sin
(ω t), the pumping signal for focusing on F2 based on time reversal acquisition are
S3: realizing simultaneously under conditions of guaranteeing that energy is constant when focusing with single focus and focus at F1, F2, array element excitation letter
Number it isWherein, △ t is S1i(t) relative to S2i(t) delay time triggered.
S4: the value that (0~1430ns) changes △ t in array element pumping signal in one cycle is focused, by temperature
Field pattern and acoustic axis temperature curve select the △ t value that high strength supersonic focus focal regions acoustic axis temperature is in platform-type distribution.
S5: after the above-mentioned relative time-delay to two signals regulates and controls, focal regions Temperature Distribution has been in platform-type temperature
Degree distribution, no longer needs to regulate and control excitation signal amplitude.
Above-mentioned high strength supersonic focus focal regions Signal averaging regulation example in, Fig. 4 be in one cycle (0~
1430ns) change the thermo parameters method that △ t value is focused, Fig. 5 is its corresponding acoustic axis temperature curve.As shown in figure 4, working as
Two 55 DEG C or more of focal regions are formed when △ t=0；A focal regions are formed as △ t=200~800ns；When △ t=1000~
Two focal regions are formed when 1400ns again.As shown in figure 5, forming an acoustic axis temperature in △ t=200ns in platform-type distribution
Focal regions.
Fig. 6 is the value of △ t in the range of 200~700ns, temperature peak, focal regions long axis (direction x), short axle (y, z
Axis direction) length with △ t change curve.As shown in fig. 6, focal regions peak temperature is with △ within the scope of △ t=200~500ns
The increase of t gradually rises, and within the scope of △ t=500~700ns, peak temperature is gradually reduced with the increase of △ t；Focal regions long axis
Length is gradually shortened with the increase of △ t, and minor axis length is almost unchanged, in △ t=200ns, focal regions long axis length longest.
Table 1 is irradiation time when △ t maximum temperature within the scope of 200~700ns reaches 65 DEG C, equivalent heat dose value
The treatment focal regions volume (treatable focal region, TFR) of 90min or more, long and short shaft length and ablation factor with
The variation of △ t.As shown in table 1, treatment focal regions long axis (x), short axle (y, z) and body are formed under conditions of △ t=200~700ns
Product is all larger than the focal regions for individually focusing and being formed at F1 or F2；Treatment focal regions long axis length first reduces with △ t increase and increases afterwards, short axle
Length variation is smaller, and the variation tendency of focal regions volume is consistent with long axis variation tendency；Ablation factor gradually subtracts with the increase of △ t
It is small.Treatment focal regions volume and ablation factor are maximum when △ t=200ns, that is, acoustic axis Temperature Distribution is in platform-type distribution.
Table 1
Embodiment 2:
S1: sine wave point sound source S is set at focus objects F1 (62.5,0,0)0(t)=P0Sin (ω t) is based on the time
Reversal process, which obtains, to be focused on the pumping signal of F1 and is
S2: sine wave point sound source S is set at the focus objects F2 (75,0,0) with F1 distance L=12.5mm0(t)=
P0Sin (ω t), the pumping signal for focusing on F2 based on time reversal acquisition are
S3: realizing simultaneously under conditions of guaranteeing that energy is constant when focusing with single focus and focus at F1, F2, array element excitation letter
Number it isWherein, △ t is S1i(t) relative to S2i(t) delay time triggered.
S4: the value that (0~1430ns) changes △ t in array element pumping signal in one cycle is focused, by temperature
Field pattern and acoustic axis temperature curve select the △ t value that high strength supersonic focus focal regions acoustic axis temperature is in platform-type distribution.
S5: under the premise of guaranteeing that input gross energy is constant, two temperature maximums at goal-focus F1, F2 are utilized
T1、T2Excitation signal amplitude is regulated and controled, is S' according to gained Amplitude Ration pumping signal adjustedi(t)=MS1i(t-△t)
+(1-M)S2i(t), wherein regulation coefficient M=k (T2-T1)+b。
In the above-described example, Fig. 7 L=12.5mm, Δ t=340ns maximum temperature reach the temperature point formed at 65 DEG C
Butut.As shown in fig. 7, high-temperature area concentrates at x=65-68mm, temperature distribution is non-uniform, and Fig. 7 (C) is corresponding acoustic axis temperature
Curve, 55 DEG C of area above temperature fluctuations are 4 DEG C or so.
Fig. 8 is that maximum temperature reaches 65 DEG C and T1、T2Difference be no more than 0.05 DEG C when amplitude adjustment factor M curve graph.
As shown in figure 8, M and amplitude regulate and control preceding T when one timing of L value2-T1Value it is substantially in a linear relationship.
Fig. 9 be it is regulated after temperature profile, wherein (A) (B) is respectively xy, yz face temperature field distribution, and (C) is
Regulate and control front and back acoustic axis temperature curve through Energy distribution.As shown in figure 9, acoustic axis direction temperature in focal regions can be made after amplitude distribution regulates and controls
Degree distribution is more uniform, and 55 degrees Celsius 1 DEG C of area above temperature fluctuation on acoustic axis, Temperature Distribution is more uniform.
In conclusion the advantages of this method has:
A. the phased method of Signal averaging of high strength supersonic focus focal regions of the invention effectively makes ultrasonic energy distribution equal
It is even, as shown in Fig. 4, Fig. 7.
B. the present invention is by the focal regions sharpness of border formed after regulation, and as shown in Fig. 4, Fig. 7, and temperature rises at a temperature of
There is certain spatial gradient in drop region, as shown in figure 5, realizing to the temperature control during HIFU Treatment.
C. the phased method of Signal averaging of the invention can pass through the opposite trigger delay time △ t and excitation letter to two signals
The adjustment of number amplitude is realized the change to focal regions size, and is increased under the premise of energy is constant compared with single focus focuses
Big single irradiation damage volume, as shown in Fig. 5 and table 1, the single focus long axial length for the treatment of focal regions F1, F2 at when focusing respectively
Respectively 4.5mm and 6.0mm, treatment focal regions long axis a length of 14mm of the bifocal point focusing after Temperature Distribution regulates and controls.
D. the phased method of Signal averaging of the invention can by the adjustment of the opposite trigger delay time △ t to two signals,
Compared with single focus focuses, treatment time is reduced under the premise of gross energy is constant, improves ablation factor.As shown in table 1, single burnt
Average ablation factor when point focusing is 2.38mm3/ s, the ablation factor that bifocus focuses after thermo parameters method regulates and controls are
4.4mm3/ s improves HIFU Treatment efficiency, can clinically mitigate for patient because for the treatment of time long bring pain.
Claims (2)
1. a kind of phased method of Signal averaging of high strength supersonic focus focal regions, which comprises the following steps:
S1: sine wave point sound source is set at focus objects F1
S0(t)=P0Sin (ω t) ... ... ... ... ... ... ... ... ... formula (1),
It is obtained based on time reversal and focuses on the pumping signal of F1 and be
Wherein,For each array element pumping signal initial phase, i is array element label, P1Sound pressure amplitude is inputted for energy converter；
S2: with the focus objects F2 of F1 distance L at be arranged sine wave point sound source
S0(t)=P0Sin (ω t) ... ... ... ... ... ... ... ... ... formula (1),
It is obtained based on time reversal and focuses on the pumping signal of F2 and be
Wherein,For each array element pumping signal initial phase, i is array element label, P2Sound pressure amplitude is inputted for energy converter；
S3: under conditions of guaranteeing that energy is constant when focusing with single focus, the excitation obtained when focusing at F1, F2 respectively is believed
It number is overlapped while realizing and focused at F1, F2, array element pumping signal is
Wherein, △ t (π f of 0 < △ t < 2) is S1i(t) relative to S2i(t) delay time triggered, f are the excitation of transducer array element signal
Frequency；
S4: changing △ t in one cycle and be focused, and screening is melted as a focal regions and temperature field is in the △ t of platform-type distribution
Value；
S5: under the premise of input gross energy is constant, two temperature maximum T at goal-focus F1, F2 are utilized1、T2To excitation
Signal amplitude is regulated and controled, and is according to gained Amplitude Ration pumping signal adjusted
S′i(t)=MS1i(t-△t)+(1-M)S2i(t) ... ... ... ... ... ... formula (5),
Wherein, regulate and control coefficient M=k (T2-T1)+b, k is fitting a straight line slope, and b is the value of the point of intersection of fitting a straight line and the longitudinal axis.
2. a kind of Signal averaging of high strength supersonic focus according to claim 1 regulates and controls method, which is characterized in that protecting
Under conditions of energy is constant when card is focused with single focus, S is adjusted in 0~2 π f this cycle1i(t) and S2i(t) two letters
Number the opposite trigger delay time；When amplitude regulates and controls, under conditions of energy is constant, array element pumping signal sound need to be only redistributed
Pressure amplitude value.
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| CN108523923B (en) * | 2018-04-16 | 2021-04-20 | 天津医科大学 | Multi-frequency partition excitation method based on random distribution 82-array element phase-controlled ultrasonic transducer |
| CN113188646A (en) * | 2021-03-19 | 2021-07-30 | 韶关东阳光自动化设备有限公司 | Planar full-electronic focusing HIFU phased array and test system thereof |
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| CN103990233B (en) * | 2014-05-22 | 2017-02-01 | 天津医科大学 | Phase control method for high-strength ultrasound transcranial focusing |
| CN104353196B (en) * | 2014-11-07 | 2018-05-11 | 天津医科大学 | The amplitude modulation method that high strength supersonic is focused on through cranium |
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