CN107016661B - A kind of medical imaging procedure and device - Google Patents
A kind of medical imaging procedure and device Download PDFInfo
- Publication number
- CN107016661B CN107016661B CN201710463671.5A CN201710463671A CN107016661B CN 107016661 B CN107016661 B CN 107016661B CN 201710463671 A CN201710463671 A CN 201710463671A CN 107016661 B CN107016661 B CN 107016661B
- Authority
- CN
- China
- Prior art keywords
- specified
- region
- initial data
- pet
- data
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T5/00—Image enhancement or restoration
- G06T5/50—Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10081—Computed x-ray tomography [CT]
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10104—Positron emission tomography [PET]
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
- G06T2207/20212—Image combination
- G06T2207/20221—Image fusion; Image merging
Abstract
The problem of the embodiment of the invention provides a kind of medical imaging procedure and devices, are related to medicine technology field, are able to solve PET image artifact.This method comprises: specifying the corresponding PET initial data in region in imaging region firstly, obtaining；Then, the motion information in the specified region is obtained；To filter out the corresponding PET initial data of multiple periods for meeting specified requirements from the corresponding PET initial data in the specified region according to the motion information in the specified region；In turn, PET initial data corresponding to the multiple period carries out image reconstruction, obtains the corresponding PET image in the specified region.Technical solution provided in an embodiment of the present invention is applicable in medical imaging process.
Description
[technical field]
The present invention relates to medicine technology field more particularly to a kind of medical imaging procedures and device.
[background technique]
PET (positron emission tomography, Positron Emission Computed Tomography) is reflection lesion
Gene, metabolism and functional status display equipment.And CT (computed tomography, electronic computer x-ray tomography
Scanning technique) human body is scanned using X-ray, since the density that partes corporis humani's grouping is knitted is different, influence wearing for X-ray
Saturating power causes the received X-ray of scan detector to have differences, so as to be accurately positioned lesion, and can show out disease
The variation of stove fine structure, but CT cannot reflect the physiological metabolism of disease.
PET-CT is that PET and CT combine, and uses same examination couch and a public image work
It stands, PET image and CT image is fused together by the processing of image workstation, two kinds of images have complementary advantages, can be comprehensive
It was found that lesion, is accurately positioned and judges that lesion is good pernicious, improve disconnected accuracy.When carrying out PET-CT scanning, patient's is exhaled
The artifact that movement causes thorax abdomen image is inhaled, the imaging precision of PET-CT is influenced.In the prior art, in PET-CT scanning device
In, the sweep time of plain edition CT is 10~30s, and being held one's breath during scanning by patient can be to avoid puppet caused by breathing
Shadow；And the sweep time of PET is 3 minutes or more, the general real-time measurement that breathing phases are carried out using peripheral equipment, according to measurement
The breathing phases arrived carry out phasing, reduce respiration artefacts, improve the precision of PET-CT imaging.
In realizing process of the present invention, at least there are the following problems in the prior art for inventor's discovery:
It, can although carrying out phasing using breathing phases since CT and PET scan are substantially not completed in the same period
To reduce the respiration artefacts of PET image, but the problem of PET image respiration artefacts, still remains, and in the imaging of both modalities which, exhales
It inhales the displacement of organ caused by phase to still remain, there are deviations for the phase of the image of the image and PET scan of CT scan, so that right
There is fusion deviation in the image after the two images progress image co-registration, reduce the precision of fused image.
[summary of the invention]
In view of this, being able to solve PET image artifact the embodiment of the invention provides a kind of medical imaging procedure and device
The problem of.
In a first aspect, the embodiment of the invention provides a kind of medical imaging procedures, which comprises
It obtains and specifies the corresponding PET initial data in region in imaging region；
Obtain the motion information in the specified region；
According to the motion information in the specified region, symbol is filtered out from the corresponding PET initial data in the specified region
Close the corresponding PET initial data of multiple periods of specified requirements；
PET initial data corresponding to the multiple period carries out image reconstruction, and it is corresponding to obtain the specified region
PET image.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described to obtain the finger
Determine the motion information in region, comprising:
The corresponding PET initial data in the specified region is converted into string diagram data；
Center of gravity or amplitude analysis are carried out with the fortune in the determination specified region to the corresponding string diagram data in the specified region
Dynamic information.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described to obtain the finger
Determine the motion information in region, comprising:
The PET initial data in the specified region is divided according to specified time interval, to obtain several periods pair
The PET initial data answered；
Several described periods corresponding PET initial data is converted into string diagram data respectively；
It is described specified with determination that center of gravity or amplitude analysis are carried out to several described periods corresponding string diagram data respectively
The motion information in region.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described from described specified
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the corresponding PET initial data in region, comprising:
From several periods divided according to specified time interval, filter out meet specified requirements it is multiple when
Between the corresponding PET initial data of section.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described to obtain the finger
Determine the motion information in region, comprising:
The motion information in the specified region is obtained using respiration gate control equipment.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described respectively to described
Several periods corresponding string diagram data carries out center of gravity or amplitude analysis with the motion information in the determination specified region, packet
It includes:
Center of gravity or amplitude analysis are carried out between string diagram data corresponding several described periods, obtain position of centre of gravity-time
Curve；
According to the position of centre of gravity-time graph, obtains the specified region and believe in the movement of several periods
Breath.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is described according to the finger
The motion information for determining region, filtered out from the corresponding PET initial data in the specified region meet specified requirements it is multiple when
Between the corresponding PET initial data of section, comprising:
According to the motion amplitude of motion information, the determining difference with the first reference value is greater than the motion amplitude pair of specified numerical value
The first specified time answered；
Delete first specified time corresponding PET data；
Alternatively,
According to the motion amplitude of motion information, the determining difference with the first reference value is less than the motion amplitude pair of specified numerical value
The second specified time answered；
Pick out the second specified time corresponding PET image data.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, it is specified in the acquisition
Before the PET initial data in region further include:
The CT for obtaining imaging region positions image；
Image is positioned according to the CT of the imaging region, the specified region is identified from the imaging region.
Another aspect, the embodiment of the invention also provides a kind of medical imaging procedures, which comprises
The medical imaging data of the medical imaging data and the first mode that obtain the first mode in specified region is corresponding
Breathing phases information；
The medical imaging data for obtaining the second mode in specified region, according to the medical imaging data pair of the first mode
The breathing phases information answered, determines the medical imaging data of several periods corresponding second mode；
Image reconstruction is carried out to the medical imaging data of several described periods corresponding second mode, obtains specified area
The medical image of the second mode in domain；
Image reconstruction is carried out to the medical imaging data of the first mode, obtains the medicine of the first mode in specified region
Image；
The medical image of the first mode in specified region is merged with the medical image of the second mode in specified region.
In another aspect, the embodiment of the invention also provides a kind of medical imaging apparatus, including scanning device and master control calculate
Machine, the scanning device and main control computer communicate, and for responding the scan instruction of main control computer sending, carry out initial data
Acquisition, and initial data collected is sent to main control computer, the main control computer includes:
First acquisition unit specifies the corresponding PET initial data in region for obtaining in imaging region；
Second acquisition unit, for obtaining the motion information in the specified region；
Selecting unit, for the motion information according to the specified region, from the corresponding PET original number in the specified region
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in；
Third acquiring unit carries out image reconstruction for PET initial data corresponding to the multiple period, obtains institute
State the corresponding PET image in specified region.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, second acquisition are single
Member specifically includes:
Conversion module, for the corresponding PET initial data in the specified region to be converted to string diagram data；
Processing module, for carrying out center of gravity or amplitude analysis described in determination to the corresponding string diagram data in the specified region
The motion information in specified region.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, second acquisition are single
Member further includes
Division module is divided for the PET initial data to the specified region according to specified time interval, if to obtain
Dry period corresponding PET initial data；
The conversion module, specifically for several described periods corresponding PET initial data is converted to string respectively
Diagram data；
The processing module is specifically used for carrying out center of gravity or width to several described periods corresponding string diagram data respectively
Value analysis is with the motion information in the determination specified region.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, the selecting module tool
Body was used for from several periods divided according to specified time interval, filtered out the multiple times for meeting specified requirements
The corresponding PET initial data of section.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, first acquisition are single
Member is specifically used for obtaining the motion information in the specified region using respiration gate control equipment.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, the processing module tool
Body is also used to carry out center of gravity or amplitude analysis to string diagram data corresponding several described periods, obtains position of centre of gravity-time
Curve；And it according to the position of centre of gravity-time graph, obtains the specified region and believes in the movement of several periods
Breath.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, the selecting module tool
Body is determining corresponding greater than the specified motion amplitude of numerical value with the difference of the first reference value also with the motion amplitude according to motion information
The first specified time；And delete first specified time corresponding PET data；Alternatively, according to the movement of motion information
Amplitude, determining the second specified time corresponding less than the specified motion amplitude of numerical value with the difference of the first reference value；And it selects
Second specified time corresponding PET image data out.
Aspect and any possible implementation as described above, it is further provided a kind of implementation, the main control computer
Further include:
4th acquiring unit, the CT for obtaining imaging region position image；
Recognition unit positions image with according to the CT of the imaging region, the finger is identified from the imaging region
Determine region.
On the other hand, the embodiment of the invention also provides a kind of medical imaging apparatus, including scanning device and master control to calculate
Machine, the scanning device and main control computer communicate, and for responding the scan instruction of main control computer sending, carry out initial data
Acquisition, and initial data collected is sent to main control computer, the main control computer includes:
First acquisition unit, for obtaining the medical imaging data and the first mode of the first mode in specified region
The corresponding breathing phases information of medical imaging data；
Second acquisition unit, the medical imaging data of the second mode for obtaining specified region, according to first mould
The corresponding breathing phases information of the medical imaging data of state, determines the medical imaging of several periods corresponding second mode
Data；
Third acquiring unit carries out figure for the medical imaging data to several described periods corresponding second mode
As rebuilding, the medical image of the second mode in specified region is obtained；
4th acquiring unit carries out image reconstruction to the medical imaging data of the first mode, obtains the of specified region
The medical image of one mode；
Image processing unit, for by the second mode in the medical image of the first mode in specified region and specified region
Medical image is merged.
The embodiment of the invention provides a kind of medical imaging procedure and device, by the motion information based on specified region,
To determine that human body specifies the organ site situation of change in region, thus, the organ site in region is specified according to human body, it is described specified
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the corresponding PET initial data in region, only to full
The PET initial data of toe fixed condition carries out image reconstruction.Compared with the prior art, using technology provided in an embodiment of the present invention
Scheme filters out the PET initial data of the condition of satisfaction to specifying from human body in the corresponding PET initial data in region, to reject not
Meet the PET initial data of condition, thoroughly solves the problems, such as PET image artifact.For example, carrying out PET-CT indulging diaphragm region to human body
It when inspection, proposes that technical solution filters out breathing area corresponding PET image data when user holds one's breath using the present invention, and rejects
PET image data when respiratory movement so that respiratory movement be avoided to give PET image bring artifact, and then guarantees PET-CT's
The phase of CT image data and PET image data that image workstation obtains is identical, and fused image is avoided to merge
Deviation improves the fused precision of images.
[Detailed description of the invention]
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for this field
For those of ordinary skill, without creative efforts, it can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is a kind of method flow diagram of medical imaging provided in an embodiment of the present invention；
Fig. 2 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 3 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 4 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 4 a is a kind of position of centre of gravity-time plot provided in an embodiment of the present invention；
Fig. 4 b is another position of centre of gravity-time plot provided in an embodiment of the present invention
Fig. 5 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 6 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 7 is the method flow diagram of another medical imaging provided in an embodiment of the present invention；
Fig. 8 is a kind of composition block diagram of medical imaging apparatus provided in an embodiment of the present invention；
Fig. 9 is the composition block diagram of another medical imaging apparatus provided in an embodiment of the present invention.
[specific embodiment]
For a better understanding of the technical solution of the present invention, being retouched in detail to the embodiment of the present invention with reference to the accompanying drawing
It states.
It will be appreciated that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art under that premise of not paying creative labor it is obtained it is all its
Its embodiment, shall fall within the protection scope of the present invention.
The term used in embodiments of the present invention is only to be not intended to be limiting merely for for the purpose of describing particular embodiments
The present invention.In the embodiment of the present invention and the "an" of singular used in the attached claims, " described " and "the"
It is also intended to including most forms, unless the context clearly indicates other meaning.
It will be appreciated that though may describe to obtain in embodiments of the present invention using term first, second, third single
Member, but these acquiring units should not necessarily be limited by these terms.These terms, which are only used to will acquire unit, to be distinguished from each other out.For example,
In the case where not departing from range of embodiment of the invention, first acquisition unit can also be referred to as second acquisition unit, similarly, the
Two acquiring units can also be referred to as first acquisition unit.
Depending on context, word as used in this " if " can be construed to " ... when " or " when ...
When " or " in response to determination " or " in response to detection ".Similarly, depend on context, phrase " if it is determined that " or " if detection
(condition or event of statement) " can be construed to " when determining " or " in response to determination " or " when the detection (condition of statement
Or event) when " or " in response to detection (condition or event of statement) ".
It should be appreciated that term "and/or" used herein is only a kind of incidence relation for describing affiliated partner, indicate
There may be three kinds of relationships, for example, A and/or B, can indicate: individualism A, exist simultaneously A and B, individualism B these three
Situation.In addition, character "/" herein, typicallys represent the relationship that forward-backward correlation object is a kind of "or".
The embodiment of the invention provides a kind of medical imaging procedures, and the flow chart of this method is as shown in Figure 1, the method packet
It includes:
101, it obtains and specifies the corresponding PET initial data in region in imaging region.
Wherein, the PET initial data for specifying region is scanning device after scanning device is scanned human body appointed part
The collected PET initial data of detector, the PET initial data include the patient body carry out medical imaging process
In the collected total data of detector, i.e., the PET initial data scanned when holding one's breath including user and user ventilation
When the PET initial data that scans.
102, the motion information in the specified region is obtained.
Wherein, motion information can reflect out with patient carry out medical imaging checked in the corresponding human body of detection position
Organ site changes situation.Motion information includes but is not limited to move moment, motion amplitude etc..
103, it according to the motion information in the specified region, is screened from the corresponding PET initial data in the specified region
Meet the corresponding PET initial data of multiple periods of specified requirements out.
Wherein, specified requirements can be set in conjunction with the diagnostic requirements of doctor.
Specifically, illustrating so that chest scans as an example.Doctor to chest carry out PET scan when, due to
When family is taken a breath, the corresponding organ of the breathing area of user (for example, heart, apex pulmonis etc.) position occurs with the respiratory intensity of user
Change, and user is when holding one's breath, the corresponding organ site of breathing area guarantee it is constant because after patient organ position is mobile can pair
Scanning generates image and causes artifact, so that the diagnosis of doctor is influenced, so when carrying out PET scan to chest, it is desirable to
Data when holding one's breath to user, and analyzed by the motion information to breathing area, thus, determine user currently whether in screen
The state of gas can filter out corresponding PET initial data when user holds one's breath in turn.
It should be noted that above-mentioned screening patient when holding one's breath corresponding PET initial data be only a kind of citing of concrete application,
Not as the specific restriction to specified requirements.
104, PET initial data corresponding to the multiple period carries out image reconstruction, obtains the specified region pair
The PET image answered.
It should be noted that in order to save research cost, the method that the embodiment of the present invention corresponds to PET image reconstruction is continued to use existing
There is technology, the present invention is no longer separately described the process of PET image reconstruction.
The embodiment of the invention provides a kind of medical imaging procedures, by the motion information based on specified region, with determination
Human body specifies the organ site situation of change in region, thus, the organ site in region, the specified region pair are specified according to human body
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the PET initial data answered, it is only specified to meeting
The PET initial data of condition carries out image reconstruction.Compared with the prior art, using technical solution pair provided in an embodiment of the present invention
The PET initial data for filtering out the condition of satisfaction in the corresponding PET initial data in region is specified from human body, is unsatisfactory for item to reject
The PET initial data of part thoroughly solves the problems, such as PET image artifact.For example, carrying out PET-CT inspection indulging diaphragm region to human body
When, propose that technical solution filters out breathing area corresponding PET image data when user holds one's breath using the present invention, and reject breathing
PET image data when movement so that respiratory movement be avoided to give PET image bring artifact, and then guarantees the image of PET-CT
The phase of CT image data and PET image data that work station obtains is identical, and fused image is avoided fusion deviation occur,
Improve the fused precision of images.
Further, in conjunction with foregoing schemes, in order to quick obtaining to motion information, the embodiment of the present invention is directed to step
The realization of rapid 102 motion informations for obtaining the specified region provides two kinds of implementations,
First way, flow diagram is as described in Figure 2, and step 102 specifically includes:
1021A, the corresponding PET initial data in the specified region is converted into string diagram data.
Wherein, string diagram data is a kind of curve movement that can reflect human organ change in location, which can be with
It is sinusoidal or cosine image, can also be that image variation is similar to the curve image of sinusoidal image, the present invention is for the string
The form of diagram data is not construed as limiting, all to can reflect PET initial data situation of change (i.e. reflection human organ change in location)
Image data be ok.
1022A, center of gravity or amplitude analysis are carried out with the determination specified area to the corresponding string diagram data in the specified region
The motion information in domain.
The second way, flow diagram is as described in Figure 3, and step 102 specifically includes:
1021B, the motion information that the specified region is obtained using respiration gate control equipment.
Further, in conjunction with foregoing schemes, in order to further increase the motion information for obtaining specified region, the present invention is implemented
Example additionally provides another implementation, as shown in figure 4, the motion information that step 102 obtains the specified region is specifically also wrapped
It includes:
1023, the PET initial data in the specified region is divided according to specified time interval, to obtain several
Period corresponding PET initial data.
By dividing the PET initial data in specified region according to specified time interval, by longer PET original number
According to shorter data are divided into, data processing complexity can be reduced to a certain extent, conducive to terminal log according to being handled.
Wherein, the specified region is the vertical diaphragm region of human body.
Wherein, specified time interval can according to actual application demand and/or PET scan equipment to body scans when
Between set.For example, the pet detector of the equipment is made of multiple detection rings for one 2 meters of PET scan equipment,
The axial visual field of pet detector is long, carries out the time that a PET scan needs 30 seconds to user, then the operator of PET device can
It is divided into 3 seconds with being arranged between specified time, the acquired original data that PET scan once obtains were divided into according to 3 seconds time intervals
10 periods corresponding acquired original data.
Since the PET scan time is long, the initial data of PET scan is long, by collected longer PET
Initial data is divided according to certain time interval, is analyzed each period after division, thus make
Motion information is more acurrate, and then the PET initial data for finally screening out is made more to meet the requirements.
Center of gravity or amplitude analysis are carried out between string diagram data corresponding several described periods, obtain position of centre of gravity-time
Curve.
Wherein, the embodiment of the present invention carries out center of gravity for string diagram data or amplitude analysis obtains position of centre of gravity-time graph
Realization provide two ways:
A kind of mode is to determine that corresponding PET initial data of each period obtains after carrying out center of gravity or amplitude analysis
Then obtained parameter is directly drawn out position of centre of gravity-time graph according to time order and function by parameter, thus according to described heavy
Heart position-time graph obtains the specified region in the motion information of several periods.
In order to facilitate understanding, embodiment of the present invention provides a kind of position of centre of gravity-time plot, as shown in fig. 4 a,
Wherein, the abscissa of the curve graph indicates the time of PET scan, and ordinate indicates the ginseng obtain after center of gravity or amplitude analysis
Number, can reflect the corresponding organ present position in human body respiration region.It should be noted that the center of gravity position of above-mentioned offer
A kind of-schematic diagram of the time plot only based on present invention offer principle offer is set, not as to specific restriction of the invention.
When another way, preset a basic parameter, then PET initial data corresponding to some time into
The parameter obtained after row center of gravity or amplitude analysis is compared with basic parameter, by calculating the parameter obtained after analysis and basic parameter
Difference, position of centre of gravity-time graph is obtained, to obtain the specified region according to the position of centre of gravity-time graph and exist
The motion information of several periods.
In order to facilitate understanding, the embodiment of the invention provides a kind of line charts, as shown in Figure 4 b, wherein the line chart
Abscissa indicates the time of PET scan, as motion amplitude corresponding time, ordinate indicate the center of gravity phase of PET image with
With reference to the difference of center of gravity phase, the motion amplitude of motion information is indicated.It should be noted that the line chart of above-mentioned offer is only base
A kind of schematic diagram that principle provides is provided in the present invention, not as to specific restriction of the invention.
Further, it in conjunction with foregoing schemes, is directed to and filters out symbol from the corresponding PET initial data in the specified region
The realization for closing the corresponding PET initial data of multiple periods of specified requirements, the embodiment of the invention provides another realization sides
Method, flow chart include: as shown in Figure 5
1031, it from described several periods divided according to specified time interval, filters out and meets specified item
Corresponding PET initial data of multiple periods of part.
Wherein, the corresponding PET initial data of multiple periods that screening meets specified requirements can be by following two side
Formula,
The first implementation:
Step 1, the motion amplitude according to motion information, the determining difference with the first reference value are greater than the movement of specified numerical value
Amplitude corresponding first specified time.
Wherein, the first reference value is to react the reference value of position of centre of gravity variation degree.First reference value can be fixed
Numerical value is also possible to the numerical value of dynamic change.It is illustrated in conjunction with the two kinds of curves enumerated in above-described embodiment.It is directed to Fig. 4 a
In curve graph, which was corresponding motion amplitude of the upper period, therefore reference value in this case is
State variation, by by corresponding motion amplitude of each period movement width corresponding with the period adjacent upper period
Value compares, to obtain the biggish motion amplitude of the motion change corresponding period；And for the curve graph in Fig. 4 b, ordinate
It is PET image center of gravity phase and the difference with reference to center of gravity phase, indicates PET image position of centre of gravity and with reference to the close of position of centre of gravity
Therefore degree selects numerical value 0 as the first reference value, the first reference value is fixed numerical value at this time.In Fig. 4 b curve graph,
The part corresponding time of the fold line distance abscissa certain distance of side or lower section is at the first time on the horizontal scale.
Specifically, for human body indulges the corresponding PET image in diaphragm region, since when user, which takes a breath, to be breathed, user's is exhaled
The corresponding organ in region is inhaled as the respiratory intensity of user is displaced, and therefore, obtained position of centre of gravity-time graph is in user
Ventilation breathed in the corresponding time, and the amplitude of corresponding ordinate changes greatly in position of centre of gravity-time graph, i.e. motion information
Motion amplitude change greatly.When holding one's breath, the corresponding organ site of the breathing area of user remains unchanged user, center of gravity position
Set-time graph in corresponding ordinate amplitude variation it is gentle, i.e. the motion amplitude variation of motion information is gentle.
Wherein, PET scan equipment can determine user by the analysis of the motion amplitude change shape to motion information
Corresponding time when corresponding time and user take a breath when holding one's breath.Wherein, the first specified time was that patient is corresponding when taking a breath
Time.
Step 2 deletes first specified time corresponding PET data.
Wherein, the first specified time corresponding PET initial data refers to that PET scan equipment when patient takes a breath is collected
Acquired original data.
It should be noted that the specified region that the first specified time corresponding PET initial data is got from step 101
It is deleted in corresponding PET initial data, so that remaining PET initial data is user's screen in the PET initial data got
Corresponding PET initial data when gas, and then filter out PET initial data when user holds one's breath.
Second of implementation:
Step 1, the motion amplitude according to motion information, the determining difference with the first reference value are less than the movement of specified numerical value
Amplitude corresponding second specified time.
Wherein, corresponding time when the second specified time held one's breath for patient.
Determine that first is specified in the Method And Principle and the first implementation of the second specified time it should be noted that determining
The Method And Principle of time is identical, and therefore, details are not described herein.
Step 2 picks out the second specified time corresponding PET initial data.
Wherein, the second specified time corresponding PET initial data refers to that PET scan equipment when patient holds one's breath is collected
Initial data.
Further, in order to be accurately obtained the acquired original data in specified region, the place of PET scan process is improved
Speed is managed, is based on this, the embodiment of the invention provides another implementation methods, as shown in fig. 6, in the acquisition imaging region
Before the PET acquired original data in specified region, further includes:
105, the CT for obtaining imaging region positions image.
Wherein, it is a kind of structure chart that CT, which positions image, the schematic diagram of the structure for reflecting human body.
106, image is positioned according to the CT of the imaging region, the specified region is identified from the imaging region.
During patient does PET scan, the body of patient is fixed on the designated position of detection bed of PET scan equipment,
And the specified region of the detection bed is divided into several zonules according to certain principle, these several zonules are right respectively
Answer different scanning bed codes.Therefore, when carrying out PET scan, each position of the body of patient and the detection of PET scan equipment
There are specified mapping relations in the scanning bed code of bed, that is, CT positions the detection of the various pieces and PET scan equipment of image
There are specified mapping relations in the scanning bed code of bed, by the mapping relations, can be positioned and be schemed according to the CT of the imaging region
Picture identifies the vertical diaphragm region of human body from the imaging region.
Supplementary explanation, during making PET scan, response of the PET scan equipment for the substance variation of detection
Speed faster, can also configure PET sensitivity, according to the area Zong Ge of the axial length of PET scan equipment and human body
The length in domain optimizes configuration to the sensitivity of PET device, and user's breathing area of identification is placed in PET scan equipment
The sensitive highest section of performance.
In conjunction with the medical imaging procedure that above-described embodiment proposes, the embodiment of the present invention also proposed another medical imaging side
Method, flow chart are as described in Figure 7, which comprises
201, the medical imaging data of the first mode in specified region and the medical imaging data of the first mode are obtained
Corresponding breathing phases information.
Wherein, the medical imaging data of first mode can be CT data, MR (magnetic resonance, magnetic resonance)
Data etc..And scanning device collects the medical imaging CT data of first mode or the fast speed of MR data, is usually suffering from
Can complete to scan entire patient in this period that person holds one's breath, therefore, CT data or MR data rebuild after
To image can by allow avoided and patient holds one's breath breathing caused by artifact.
202, the medical imaging data for obtaining the second mode in specified region, according to the medical imaging number of the first mode
According to corresponding breathing phases information, the medical imaging data of several periods corresponding second mode is determined.
Wherein, the medical imaging data of second mode can be PET data, the doctor of usual scanning device acquisition second mode
The speed for learning imaging data (PET data) is slow relative to the speed of the medical imaging data of acquisition first mode, holds one's breath in patient
This period in, scanning device cannot complete the acquisition of the medical imaging data (PET data) of primary complete second mode.
203, image reconstruction is carried out to the medical imaging data of several periods corresponding second mode, obtains specified area
The medical image of the second mode in domain.
It should be noted that in order to avoid medical image of the patient respiratory to second mode causes artifact, to the second mould
The medical imaging data of state can be using the medical imaging procedure that above-described embodiment proposes to second mode before carrying out image reconstruction
Medical imaging data handled, thus, obtain the medical image of second mode.
204, image reconstruction is carried out to the medical imaging data of the first mode, obtains the first mode in specified region
Medical image.
205, the medical image of the medical image of the first mode in specified region and the second mode in specified region is carried out
Fusion.
It should be noted that in order to facilitate diagnosis, the medical image of usual first mode and the medicine of second mode
Image is incorporated in an image and shows.
Specifically, for example, in medical imaging, it is generally the case that PET image data and CT image data are carried out image
Fusion, synthesizes an image and is shown to doctor's.The image workstation of PET-CT scanning device schemes PET image data and CT
Picture data carry out image using PET image data and the respective imaging characteristics of CT image data, to PET image and CT image data
Both images are carried out spatial registration and combination, these image datas are combined into single image by conversion process.
But the time of CT scan is less than the time of PET scan, for the scanning in the vertical diaphragm region of human body, Ke Yi
User, which holds one's breath, completes CT scan in the regular hour, so as to avoid user from breathing the influence to CT scan data, and with
It is unable to complete PET scan in the period that family is held one's breath, therefore will receive the influence of user's breathing, so that PET image generates artifact.
And method is proposed by using above-described embodiment, the PET initial data when PET initial data is eliminated due to patient's ventilation,
PET initial data when being held one's breath using user carries out data reconstruction, so that the artifact in PET image is eliminated, so that carrying out
The PET image of image co-registration is consistent with CT image phase, and then improves the precision of image co-registration.
The embodiment of the invention provides a kind of medical imaging procedures, by the motion information based on specified region, with determination
Human body specifies the organ site situation of change in region, thus, the organ site in region, the specified region pair are specified according to human body
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the PET initial data answered, it is only specified to meeting
The PET initial data of condition carries out image reconstruction.Compared with the prior art, using technical solution pair provided in an embodiment of the present invention
The PET initial data for filtering out the condition of satisfaction in the corresponding PET initial data in region is specified from human body, is unsatisfactory for item to reject
The PET initial data of part thoroughly solves the problems, such as PET image artifact.For example, carrying out PET-CT inspection indulging diaphragm region to human body
When, propose that technical solution filters out breathing area corresponding PET image data when user holds one's breath using the present invention, and reject breathing
PET image data when movement so that respiratory movement be avoided to give PET image bring artifact, and then guarantees the image of PET-CT
The phase of CT image data and PET image data that work station obtains is identical, and fused image is avoided fusion deviation occur,
Improve the fused precision of images.
Based on the above method, the embodiment of the invention provides a kind of medical imaging apparatus, as shown in figure 8, including that scanning is set
Standby 31 and main control computer 32, the scanning device 31 are communicated with main control computer 32, are issued for responding main control computer 32
Scan instruction, carry out raw data acquisition, and initial data collected be sent to main control computer 32, the master control meter
Calculation machine 32 includes:
First acquisition unit specifies the corresponding PET initial data in region for obtaining in imaging region.
Second acquisition unit, for obtaining the motion information in the specified region.
Selecting unit, for the motion information according to the specified region, from the corresponding PET original number in the specified region
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in.
Third acquiring unit carries out image reconstruction for PET initial data corresponding to the multiple period, obtains institute
State the corresponding PET image in specified region.
Optionally, the second acquisition unit specifically includes:
Conversion module, for the corresponding PET initial data in the specified region to be converted to string diagram data.
Processing module, for carrying out center of gravity or amplitude analysis described in determination to the corresponding string diagram data in the specified region
The motion information in specified region.
Optionally, the second acquisition unit further include:
Division module is divided for the PET initial data to the specified region according to specified time interval, if to obtain
Dry period corresponding PET initial data.
The conversion module, specifically for several described periods corresponding PET initial data is converted to string respectively
Diagram data.
The processing module is specifically used for carrying out center of gravity or width to several described periods corresponding string diagram data respectively
Value analysis is with the motion information in the determination specified region.
Optionally, the selecting module was specifically used for from several periods divided according to specified time interval
In, filter out the corresponding PET initial data of multiple periods for meeting specified requirements.
Optionally, the first acquisition unit is specifically used for obtaining the fortune in the specified region using respiration gate control equipment
Dynamic information.
Optionally, the processing module is specifically also used to carry out weight to string diagram data corresponding several described periods
The heart or amplitude analysis obtain position of centre of gravity-time graph；And it according to the position of centre of gravity-time graph, obtains described specified
Motion information of the region in several periods.
Optionally, the selecting module is specifically also with the motion amplitude according to motion information, determining and the first reference value
Difference be greater than motion amplitude corresponding first specified time of specified numerical value；And deletion first specified time is corresponding
PET data；Alternatively, the determining difference with the first reference value is less than the movement of specified numerical value according to the motion amplitude of motion information
Amplitude corresponding second specified time；And pick out the second specified time corresponding PET image data.
Optionally, the main control computer 32 further include:
4th acquiring unit, the CT for obtaining imaging region position image.
Recognition unit positions image with according to the CT of the imaging region, the finger is identified from the imaging region
Determine region.
The embodiment of the invention provides a kind of medical imaging apparatus, by the motion information based on specified region, with determination
Human body specifies the organ site situation of change in region, thus, the organ site in region, the specified region pair are specified according to human body
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the PET initial data answered, it is only specified to meeting
The PET initial data of condition carries out image reconstruction.Compared with the prior art, using technical solution pair provided in an embodiment of the present invention
The PET initial data for filtering out the condition of satisfaction in the corresponding PET initial data in region is specified from human body, is unsatisfactory for item to reject
The PET initial data of part thoroughly solves the problems, such as PET image artifact.For example, carrying out PET-CT inspection indulging diaphragm region to human body
When, propose that technical solution filters out breathing area corresponding PET image data when user holds one's breath using the present invention, and reject breathing
PET image data when movement so that respiratory movement be avoided to give PET image bring artifact, and then guarantees the image of PET-CT
The phase of CT image data and PET image data that work station obtains is identical, and fused image is avoided fusion deviation occur,
Improve the fused precision of images.
On the other hand, the embodiment of the invention also provides another medical imaging apparatus, as shown in figure 9, including that scanning is set
Standby 41 and main control computer 42, the scanning device 41 are communicated with main control computer 42, are issued for responding main control computer 42
Scan instruction, carry out raw data acquisition, and initial data collected be sent to main control computer 42, the master control meter
Calculation machine 42 includes:
First acquisition unit, for obtaining the medical imaging data and the first mode of the first mode in specified region
The corresponding breathing phases information of medical imaging data.
Second acquisition unit, the medical imaging data of the second mode for obtaining specified region, according to first mould
The corresponding breathing phases information of the medical imaging data of state, determines the medical imaging of several periods corresponding second mode
Data.
Third acquiring unit carries out figure for the medical imaging data to several described periods corresponding second mode
As rebuilding, the medical image of the second mode in specified region is obtained.
4th acquiring unit carries out image reconstruction to the medical imaging data of the first mode, obtains the of specified region
The medical image of one mode.
Image processing unit, for by the second mode in the medical image of the first mode in specified region and specified region
Medical image is merged.
The embodiment of the invention provides a kind of medical imaging apparatus, by the motion information based on specified region, with determination
Human body specifies the organ site situation of change in region, thus, the organ site in region, the specified region pair are specified according to human body
The corresponding PET initial data of multiple periods for meeting specified requirements is filtered out in the PET initial data answered, it is only specified to meeting
The PET initial data of condition carries out image reconstruction.Compared with the prior art, using technical solution pair provided in an embodiment of the present invention
The PET initial data for filtering out the condition of satisfaction in the corresponding PET initial data in region is specified from human body, is unsatisfactory for item to reject
The PET initial data of part thoroughly solves the problems, such as PET image artifact.For example, carrying out PET-CT inspection indulging diaphragm region to human body
When, propose that technical solution filters out breathing area corresponding PET image data when user holds one's breath using the present invention, and reject breathing
PET image data when movement so that respiratory movement be avoided to give PET image bring artifact, and then guarantees the image of PET-CT
The phase of CT image data and PET image data that work station obtains is identical, and fused image is avoided fusion deviation occur,
Improve the fused precision of images.
It is apparent to those skilled in the art that for convenience and simplicity of description, the system of foregoing description,
The specific work process of device and unit, can refer to corresponding processes in the foregoing method embodiment, and details are not described herein.
In several embodiments provided by the present invention, it should be understood that disclosed system, device and method can be with
It realizes by another way.For example, the apparatus embodiments described above are merely exemplary, for example, the unit
It divides, only a kind of logical function partition, there may be another division manner in actual implementation, for example, multiple units or group
Part can be combined or can be integrated into another system, or some features can be ignored or not executed.Another point, it is shown
Or the mutual coupling, direct-coupling or communication connection discussed can be through some interfaces, device or unit it is indirect
Coupling or communication connection can be electrical property, mechanical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
It, can also be in addition, the functional units in various embodiments of the present invention may be integrated into one processing unit
It is that each unit physically exists alone, can also be integrated in one unit with two or more units.Above-mentioned integrated list
Member both can take the form of hardware realization, can also realize in the form of hardware adds SFU software functional unit.
The above-mentioned integrated unit being realized in the form of SFU software functional unit can store and computer-readable deposit at one
In storage media.Above-mentioned SFU software functional unit is stored in a storage medium, including some instructions are used so that a computer
It is each that device (can be personal computer, server or network equipment etc.) or processor (Processor) execute the present invention
The part steps of embodiment the method.And storage medium above-mentioned includes: USB flash disk, mobile hard disk, read-only memory (Read-
Only Memory, ROM), random access memory (Random Access Memory, RAM), magnetic or disk etc. it is various
It can store the medium of program code.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (4)
1. a kind of medical imaging procedure, which is characterized in that the described method includes:
It obtains and specifies the corresponding PET initial data in region in imaging region；
Obtain the motion information in the specified region；
According to the motion information in the specified region, is filtered out from the corresponding PET initial data in the specified region and meet finger
Corresponding PET initial data of multiple periods of fixed condition；
PET initial data corresponding to the multiple period carries out image reconstruction, obtains the corresponding PET figure in the specified region
Picture；
The motion information for obtaining the specified region, comprising:
The PET initial data in the specified region is divided according to specified time interval, it is corresponding to obtain several periods
PET initial data；
Several described periods corresponding PET initial data is converted into string diagram data respectively；
Center of gravity or amplitude analysis are carried out with the determination specified region to several described periods corresponding string diagram data respectively
Motion information；
It is described described specified with determination to several described periods corresponding string diagram data progress center of gravity or amplitude analysis respectively
The motion information in region, comprising:
Center of gravity or amplitude analysis are carried out to several described periods corresponding string diagram data, obtain position of centre of gravity-time graph；
According to the position of centre of gravity-time graph, the specified region is obtained in the motion information of several periods.
2. the method according to claim 1, wherein described from the corresponding PET initial data in the specified region
In filter out the corresponding PET initial data of multiple periods for meeting specified requirements, comprising:
From several periods divided according to specified time interval, the multiple periods for meeting specified requirements are filtered out
Corresponding PET initial data.
3. the method according to claim 1, wherein the motion information according to the specified region, from institute
It states and filters out the corresponding PET initial data of multiple periods for meeting specified requirements in the corresponding PET initial data in specified region,
Include:
It is determining corresponding greater than the specified motion amplitude of numerical value with the difference of the first reference value according to the motion amplitude of motion information
First specified time；
Delete first specified time corresponding PET data；
Alternatively,
It is determining corresponding less than the specified motion amplitude of numerical value with the difference of the first reference value according to the motion amplitude of motion information
Second specified time；
Pick out the second specified time corresponding PET image data.
4. a kind of medical imaging apparatus, which is characterized in that including scanning device and main control computer, the scanning device and master control
Computer communication carries out raw data acquisition, and will be collected original for responding the scan instruction of main control computer sending
Data are sent to main control computer, and the main control computer includes:
First acquisition unit specifies the corresponding PET initial data in region for obtaining in imaging region；
Second acquisition unit, for obtaining the motion information in the specified region；
Selecting unit, for the motion information according to the specified region, from the corresponding PET initial data in the specified region
Filter out the corresponding PET initial data of multiple periods for meeting specified requirements；
Third acquiring unit carries out image reconstruction for PET initial data corresponding to the multiple period, obtains the finger
Determine the corresponding PET image in region；
The second acquisition unit specifically includes:
Conversion module, for the corresponding PET initial data in the specified region to be converted to string diagram data；
Processing module, it is described specified with determination for carrying out center of gravity or amplitude analysis to the corresponding string diagram data in the specified region
The motion information in region；
Division module is divided for the PET initial data to the specified region according to specified time interval, to obtain several
Period corresponding PET initial data；
The conversion module, specifically for several described periods corresponding PET initial data is converted to string figure number respectively
According to；
The processing module is specifically used for carrying out center of gravity or amplitude point to several described periods corresponding string diagram data respectively
Analysis is with the motion information in the determination specified region；
The processing module is specifically also used to carry out center of gravity or amplitude analysis to several described periods corresponding string diagram data,
Obtain position of centre of gravity-time graph；And according to the position of centre of gravity-time graph, if obtaining the specified region described
The motion information of dry period.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710463671.5A CN107016661B (en) | 2017-06-19 | 2017-06-19 | A kind of medical imaging procedure and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710463671.5A CN107016661B (en) | 2017-06-19 | 2017-06-19 | A kind of medical imaging procedure and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107016661A CN107016661A (en) | 2017-08-04 |
| CN107016661B true CN107016661B (en) | 2019-10-15 |
Family
ID=59453008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710463671.5A Active CN107016661B (en) | 2017-06-19 | 2017-06-19 | A kind of medical imaging procedure and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107016661B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468267B (en) * | 2017-08-11 | 2020-12-04 | 上海联影医疗科技股份有限公司 | Data processing method and medical imaging equipment |
| CN107569251B (en) * | 2017-08-29 | 2020-12-22 | 上海联影医疗科技股份有限公司 | Medical imaging method and system and non-transitory computer readable storage medium |
| CN107693041A (en) * | 2017-11-24 | 2018-02-16 | 上海联影医疗科技有限公司 | Medical scanning and system |
| CN109363702B (en) * | 2018-09-29 | 2023-01-20 | 上海联影医疗科技股份有限公司 | Medical imaging method and system and radiation dose acquisition method and system |
| CN110415311B (en) * | 2019-07-29 | 2024-04-16 | 上海联影医疗科技股份有限公司 | PET image reconstruction method, system, readable storage medium and apparatus |
| CN110544283B (en) * | 2019-09-06 | 2023-06-16 | 上海联影医疗科技股份有限公司 | PET reconstruction data screening method, device, terminal and storage medium |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102783966A (en) * | 2011-05-03 | 2012-11-21 | 通用电气公司 | Method and apparatus for motion correcting medical images |
| CN106251380A (en) * | 2016-07-29 | 2016-12-21 | 上海联影医疗科技有限公司 | Image rebuilding method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9495771B2 (en) * | 2013-05-10 | 2016-11-15 | The General Hospital Corporation | Systems and methods for motion correction in positron emission tomography imaging |
-
2017
- 2017-06-19 CN CN201710463671.5A patent/CN107016661B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102783966A (en) * | 2011-05-03 | 2012-11-21 | 通用电气公司 | Method and apparatus for motion correcting medical images |
| CN106251380A (en) * | 2016-07-29 | 2016-12-21 | 上海联影医疗科技有限公司 | Image rebuilding method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107016661A (en) | 2017-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107016661B (en) | A kind of medical imaging procedure and device | |
| CN109035355B (en) | System and method for PET image reconstruction | |
| JP2021526949A (en) | Lung volume gate X-ray imaging system and method | |
| CN104363833B (en) | Video generation device and image generating method | |
| CN103845073B (en) | MR for PET correction for attenuations scans selection | |
| JP3639825B2 (en) | Moving image display method, program, computer-readable storage medium, and moving image display device | |
| CN109741284A (en) | System and method for correcting the mismatch as caused by respiratory movement in PET imaging | |
| US20060178575A1 (en) | Device-less gating of physiological movement for improved image detection | |
| CN104424385B (en) | A kind of evaluation method and device of medical image | |
| CN104997528A (en) | X-ray computed-tomography apparatus and imaging-condition-seting support apparatus | |
| CN109009200A (en) | System and method for positron emission tomography image reconstruction | |
| CN105120738B (en) | Narrow treatment is planned | |
| EP3052018A1 (en) | An electrical impedance tomography system | |
| CN106725570A (en) | Imaging method and system | |
| CN102805640B (en) | Control the method for Medical Equipment and there is the facility of Medical Equipment | |
| CN106963410A (en) | PET imaging systems and its imaging method | |
| CN102207991A (en) | Medical image diagnosis assisting technology | |
| CN108289651A (en) | System for tracking the ultrasonic probe in body part | |
| US11950940B2 (en) | System and method for determining radiation parameters | |
| JP2006341092A (en) | Method for acquiring, analyzing and displaying medical image data set | |
| US20070173724A1 (en) | System and method for three-dimensional airway reconstruction, assessment and analysis | |
| CN109938768A (en) | Ultrasonic imaging method, device, computer equipment and storage medium | |
| JP7144129B2 (en) | Medical image diagnosis device and medical information management device | |
| JP3219280B2 (en) | SPECT tomographic imaging system | |
| JP7387409B2 (en) | Medical image processing device, medical image processing method, medical image processing program |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 201807 Shanghai city Jiading District Industrial Zone Jiading Road No. 2258 Patentee after: Shanghai Lianying Medical Technology Co., Ltd Address before: 201807 Shanghai city Jiading District Industrial Zone Jiading Road No. 2258 Patentee before: SHANGHAI UNITED IMAGING HEALTHCARE Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |