CN107001422A - 结合变形链球菌的靶向肽、包含所述肽的构建体及其用途 - Google Patents

结合变形链球菌的靶向肽、包含所述肽的构建体及其用途 Download PDF

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Publication number
CN107001422A
CN107001422A CN201580049114.8A CN201580049114A CN107001422A CN 107001422 A CN107001422 A CN 107001422A CN 201580049114 A CN201580049114 A CN 201580049114A CN 107001422 A CN107001422 A CN 107001422A
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China
Prior art keywords
peptide
seq
amino acid
antimicrobial
acid sequence
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Pending
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CN201580049114.8A
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English (en)
Chinese (zh)
Inventor
R·H·埃克特
C·W·卡普兰
P·A·库迈
B·C·瓦纳姆
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C3J Therapeutics Inc
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C3 Jian Inc
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Publication of CN107001422A publication Critical patent/CN107001422A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/315—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Birds (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
CN201580049114.8A 2014-07-11 2015-07-07 结合变形链球菌的靶向肽、包含所述肽的构建体及其用途 Pending CN107001422A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462023678P 2014-07-11 2014-07-11
US62/023,678 2014-07-11
PCT/US2015/039439 WO2016007551A1 (en) 2014-07-11 2015-07-07 Targeting peptides that bind s. mutans, constructs comprising such peptides and uses thereof

Publications (1)

Publication Number Publication Date
CN107001422A true CN107001422A (zh) 2017-08-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580049114.8A Pending CN107001422A (zh) 2014-07-11 2015-07-07 结合变形链球菌的靶向肽、包含所述肽的构建体及其用途

Country Status (7)

Country Link
US (1) US20160031941A1 (enExample)
EP (1) EP3166959A4 (enExample)
JP (1) JP2017526640A (enExample)
CN (1) CN107001422A (enExample)
AU (1) AU2015287917A1 (enExample)
CA (1) CA2955057A1 (enExample)
WO (1) WO2016007551A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112920279A (zh) * 2021-03-09 2021-06-08 海南大学 一种海水提铀用抗生物污损型聚合肽水凝胶材料及其制备方法和应用
CN113402613A (zh) * 2021-01-19 2021-09-17 东北农业大学 抗菌肽ll37活性中心衍生肽二倍体抗菌肽lg及其制备方法和应用
CN113461781A (zh) * 2021-07-14 2021-10-01 中国药科大学 抗菌肽gs18及其用途

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
CN113861268B (zh) 2014-05-21 2025-04-01 恩特拉达治疗学股份有限公司 细胞穿透肽及其制备和使用方法
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
CN106589136B (zh) * 2016-11-25 2018-11-20 东北农业大学 基于fv7抗生物膜的杂合抗菌肽及制备方法和应用
WO2018191529A1 (en) * 2017-04-14 2018-10-18 C3 Jian, Llc Dental varnishes that release specifically targeted antimicrobial peptides and/or fluoride
WO2018191533A1 (en) 2017-04-14 2018-10-18 C3 Jian Llc Dental strips for the delivery of specifically targeted antimicrobial peptides
US11339192B2 (en) 2017-10-04 2022-05-24 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
EP3746105A4 (en) 2018-01-29 2022-05-18 Ohio State Innovation Foundation CYCLIC PEPTIDYLIN HIBITORS OF THE CAL-PDZ-BINDING DOMAIN
TW201945014A (zh) 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法
US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
JP7531822B2 (ja) * 2019-11-08 2024-08-13 静岡県公立大学法人 化合物又はその塩
WO2024121057A1 (en) * 2022-12-05 2024-06-13 Novozymes A/S A composition for removing body grime

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040105824A1 (en) * 2002-07-03 2004-06-03 Goodman Steven D. Preventing tooth decay and infective endocarditis using natural oligopeptides
US20070178054A1 (en) * 2005-11-09 2007-08-02 Madhyastha Srinivasa Oral antimicrobial composition
CN101511382A (zh) * 2006-09-06 2009-08-19 加利福尼亚大学董事会 特异性靶向抗微生物肽及其应用
US20100202983A1 (en) * 2009-02-09 2010-08-12 Jernberg Gary R Selectively targeted antimicrobials for the treatment of periodontal disease
US20100316643A1 (en) * 2009-02-05 2010-12-16 The Regents Of The University Of California Targeted antimicrobial moieties
US20120308638A1 (en) * 2009-12-17 2012-12-06 Mathew Upton Antimicrobial peptides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040105824A1 (en) * 2002-07-03 2004-06-03 Goodman Steven D. Preventing tooth decay and infective endocarditis using natural oligopeptides
US20070178054A1 (en) * 2005-11-09 2007-08-02 Madhyastha Srinivasa Oral antimicrobial composition
CN101511382A (zh) * 2006-09-06 2009-08-19 加利福尼亚大学董事会 特异性靶向抗微生物肽及其应用
US20100316643A1 (en) * 2009-02-05 2010-12-16 The Regents Of The University Of California Targeted antimicrobial moieties
US20100202983A1 (en) * 2009-02-09 2010-08-12 Jernberg Gary R Selectively targeted antimicrobials for the treatment of periodontal disease
US20120308638A1 (en) * 2009-12-17 2012-12-06 Mathew Upton Antimicrobial peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DING等: "Antimicrobial and anti-biofilm effect of Bac8c on major bacteria associated with dental caries and Streptococcus mutans biofilms", 《PEPTIDES》 *
RANDAL RCKERT等: "Targeted Killing of Streptococcus mutans by a Pheromone-Guided "Smart" Antimicrobial Peptide", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》 *
SHAINI THOMAS等: "CAMP: a useful resource for research on antimicrobial peptides", 《NUCLEIC ACIDS RESEARCH》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113402613A (zh) * 2021-01-19 2021-09-17 东北农业大学 抗菌肽ll37活性中心衍生肽二倍体抗菌肽lg及其制备方法和应用
CN113402613B (zh) * 2021-01-19 2022-06-14 东北农业大学 抗菌肽ll37活性中心衍生肽二倍体抗菌肽lg及其制备方法和应用
CN112920279A (zh) * 2021-03-09 2021-06-08 海南大学 一种海水提铀用抗生物污损型聚合肽水凝胶材料及其制备方法和应用
CN113461781A (zh) * 2021-07-14 2021-10-01 中国药科大学 抗菌肽gs18及其用途

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Publication number Publication date
CA2955057A1 (en) 2016-01-14
EP3166959A1 (en) 2017-05-17
US20160031941A1 (en) 2016-02-04
JP2017526640A (ja) 2017-09-14
EP3166959A4 (en) 2017-12-13
WO2016007551A1 (en) 2016-01-14
AU2015287917A1 (en) 2017-02-02

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