CN106995497A - A kind of preparation method of astragalus polyose magnesium - Google Patents
A kind of preparation method of astragalus polyose magnesium Download PDFInfo
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- CN106995497A CN106995497A CN201710391195.0A CN201710391195A CN106995497A CN 106995497 A CN106995497 A CN 106995497A CN 201710391195 A CN201710391195 A CN 201710391195A CN 106995497 A CN106995497 A CN 106995497A
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- astragalus polyose
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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Abstract
The invention discloses a kind of preparation method of astragalus polyose magnesium, radix astragali coarse powder is subjected to Microwave Extraction, efflux is obtained by purifying, then in microwave reaction instrument with MgCl2Reaction, adds Na2CO3Precipitated, load bag filter and remove free magnesium, astragalus polyose magnesium is dried to obtain through alcohol precipitation washing.The preparation method has successfully been made astragalus polyose magnesium, and method has environmental protection, efficiently, and operating process is simple, the advantages of product yield high.
Description
Technical field
The present invention relates to a kind of preparation method of astragalus polyose magnesium, belong to field of medicine and chemical technology.
Background technology
Magnesium is a kind of participation organism normal activities and the essential element of metabolic processes.Magnesium influences cell
A variety of biological functions：The signal transmission of regulating cell, participates in the synthesis of energetic supersession, protein and nucleic acid；Network can be passed through
Conjunction negative electrical charge group, the especially phosphate group in nucleotides maintain the 26S Proteasome Structure and Function of material to play；The activation of catalyzing enzyme and
Suppression and the regulation and control of cell cycle, cell propagation and cell differentiation；Magnesium also participate in maintain genome stability, and also with
Body oxidative stress is relevant with tumour generation.
Due to critical role of the magnesium in body metabolism so that the research containing magnesium products of high security and high bioactivity
The focus of scientific research is constantly in, and has been widely applied in daily life.
Astragalus polyose be legume astragalus mongolicus or Astragalus membranacus dry root is extracted, concentration, the water of purifying
Dissolubility heteroglycan.Astragalus polyose is by hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucose
Aldehydic acid etc. is constituted, can be as immunopotentiating agent or conditioning agent, while having antiviral, antitumor, anti-aging, radioresistance, resisting and answer
Sharp, anti-oxidant etc. are acted on.The complex compound of astragalus polyose because its efficiently, the characteristics of easily absorbing, at the same overcome wherein metal from
Subconstiuent is easily precipitated with other anion, and the shortcoming of poorly water-soluble receives the concern of researcher in recent years.
Chinese patent CN201110241423.9 discloses the preparation method for reporting a kind of astragalus polyose calcium complex, uses
Water extraction extracts astragalus polyose, adds calcium chloride and sodium hydroxide is complexed, and product obtains water-soluble height by processing, absorbs
The good astragalus polyose calcium of rate.
Chinese patent CN2011102128687.3, which is disclosed, reports a boar astragalus polyose iron material medicine and its preparation side
Method, is extracted using EtOH Sonicate, by processing, then the astragalus polyose ferrous solution for obtaining rufous is reacted with molysite, by processing,
Astragalus polyose iron material medicine finished product is obtained, with low cost, obtained product stability is good, water-soluble high, toxic side effect is small, turns into
Preferably mend iron material.
Chinese patent CN201510335542.9 discloses the preparation method for reporting a kind of astragalus polyose calcium, using alcohol extracting method
Astragalus polyose is extracted, after simple process, is reacted in water with calcium chloride, deionization is removed using bag filter, alcohol precipitation is obtained afterwards
To astragalus polyose calcium.
Astragalus polyose magnesium is reacted by astragalus polyose and magnesium ion to be made, improving immunity, it is anti-oxidant, antitumor in terms of
There is good effect.But the research almost not on astragalus polyose magnesium is reported at present.
The invention discloses a kind of preparation method of astragalus polyose magnesium, using extracting polysaccharide from astragalus root using microwave, and microwave is used
Method synthesizes astragalus polyose magnesium, and the preparation method has environmentally friendly, efficient advantage, and operating process is simple, product yield high.Cost is low
Honest and clean, obtained product stability is good, and water-soluble high, toxic side effect is small, is a kind of preferably benefit magnesium raw material.
The content of the invention
Concrete technology circuit of the present invention is as follows：
(1) extraction and purification of astragalus polyose
Take Milkvetch Root to be ground into coarse powder, radix astragali coarse powder is subjected to Microwave Extraction with 20% ethanol water, solid-liquid ratio is 1:5
~1:10, microwave power 200W~400W, extraction time 3h are extracted 3 times, are centrifuged extract solution after extraction, collect supernatant
Liquid, concentration, is cooled to room temperature, and concentrate is adsorbed by the macroporous absorbent resin loading after activation, then is washed with eluent flowing
It is de-, collect efflux.
(2) preparation of astragalus polyose magnesium
Efflux described in step (1) is placed in microwave reaction instrument, MgCl is added2, under microwave condition react 2~
4h, after reaction solution is concentrated, adds Na2CO3Precipitated, removed after sediment, loaded bag filter and remove free magnesium, Ran Houjia
Enter ethanol and carry out alcohol precipitation, alcohol hypostasis is scrubbed to be dried to obtain astragalus polyose magnesium.
Embodiment:
The present invention is further illustrated in the following embodiments, but is not limit the scope of the invention.
Embodiment 1
(1) extraction and purification of astragalus polyose
Take Milkvetch Root to be ground into coarse powder, 1000g radix astragali coarse powders are soaked with 5L 20% ethanol water, in power 200W
Microwave condition under extract, extraction time 3h, extract 3 times, extract solution is centrifuged after extraction, collect supernatant, concentrate, it is cold
But to room temperature, concentrate is adsorbed by the macroporous absorbent resin splitter loading of activation, with ethanol elution, loading speed is
2BV/h, elution speed is 2BV/h, collects efflux.
(2) preparation of astragalus polyose magnesium
Efflux described in step (1) is placed in microwave reaction instrument, 10g MgCl are added2, reacted under microwave condition
4h, after reaction solution is concentrated, adds Na2CO3Precipitated, removed after sediment, loaded bag filter and remove free magnesium, Ran Houjia
Enter ethanol and carry out alcohol precipitation, alcohol hypostasis is scrubbed to be dried to obtain astragalus polyose magnesium 0.79g.
Embodiment 2
(1) extraction and purification of astragalus polyose
Take Milkvetch Root to be ground into coarse powder, 1000g radix astragali coarse powders are soaked with 10L 20% ethanol water, in power 300W
Microwave condition under extract, extraction time 3h, extract 3 times, extract solution is centrifuged after extraction, collect supernatant, concentrate, it is cold
But to room temperature, concentrate is adsorbed by the macroporous absorbent resin splitter loading of activation, with ethanol elution, loading speed is
2BV/h, elution speed is 2BV/h, collects efflux.
(2) preparation of astragalus polyose magnesium
Efflux described in step (1) is placed in microwave reaction instrument, 20g MgCl are added2, reacted under microwave condition
4h, after reaction solution is concentrated, adds Na2CO3Precipitated, removed after sediment, loaded bag filter and remove free magnesium, Ran Houjia
Enter ethanol and carry out alcohol precipitation, alcohol hypostasis is scrubbed to be dried to obtain astragalus polyose magnesium 0.80g.
Embodiment 3
(1) extraction and purification of astragalus polyose
Take Milkvetch Root to be ground into coarse powder, 1000g radix astragali coarse powders are soaked with 7.5L 20% ethanol water, in power
Extracted under 400W microwave condition, extraction time 3h, extract 3 times, centrifuged extract solution after extraction, collect supernatant, it is dense
Contracting, is cooled to room temperature, and concentrate is adsorbed by the macroporous absorbent resin splitter loading of activation, with ethanol elution, loading speed
Spend for 2BV/h, elution speed is 2BV/h, collect efflux.
(2) preparation of astragalus polyose magnesium
Efflux described in step (1) is placed in microwave reaction instrument, 15g MgCl are added2, reacted under microwave condition
2h, after reaction solution is concentrated, adds Na2CO3Precipitated, removed after sediment, loaded bag filter and remove free magnesium, Ran Houjia
Enter ethanol and carry out alcohol precipitation, alcohol hypostasis is scrubbed to be dried to obtain astragalus polyose magnesium 0.78g.
Claims (5)
1. a kind of preparation method of astragalus polyose magnesium, it is characterised in that：This method comprises the following steps：
(1) extraction and purification of astragalus polyose：Take Milkvetch Root to be ground into coarse powder, radix astragali coarse powder is carried out with 20% ethanol water
Microwave Extraction, extracts 3 times, is centrifuged extract solution after extraction, collects supernatant, and concentration is cooled to room temperature, concentrate is led to
Macroporous absorbent resin splitter loading absorption after overactivation, then elution is flowed with eluent, collect efflux；
(2) preparation of astragalus polyose magnesium：Efflux described in step (1) is placed in microwave reaction instrument, MgCl is added2, open micro-
Ripple reacts instrument, by one section of reaction time, obtains reaction solution and is concentrated, adds Na2CO3Precipitated, removed after sediment,
Load bag filter and remove dissociated ion, then add ethanol and carry out alcohol precipitation, alcohol hypostasis is scrubbed to be dried to obtain astragalus polyose magnesium.
2. a kind of preparation method of astragalus polyose magnesium according to claim 1, it is characterised in that：Step (1) Microwave Extraction
The solid-liquid ratio of radix astragali coarse powder and ethanol water used is 1:5~10, microwave power is 200W~400W, and extraction time is 3h.
3. a kind of preparation method of astragalus polyose magnesium according to claim 1, it is characterised in that：It is characterized in that：Step
(1) eluent used in is ethanol, and loading speed is 2BV/h, and elution speed is 2BV/h.
4. a kind of preparation method of astragalus polyose magnesium according to claim 1, it is characterised in that：Step (2) described MgCl2
Addition be step (1) in radix astragali coarse powder amount 1%~2%.
5. a kind of preparation method of astragalus polyose magnesium according to claim 1, it is characterised in that：Step (2) reaction
Time is 2~4h.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328222A (en) * | 2007-06-20 | 2008-12-24 | 赵玉英 | Liquorice polyose metal complexes and preparation thereof |
| CN102351958A (en) * | 2011-08-22 | 2012-02-15 | 河南中医学院 | Preparation method and application of astragalus polysaccharide-calcium complex |
| CN104940277A (en) * | 2015-06-17 | 2015-09-30 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method of calcium astragalus polysaccharide |
| CN105924535A (en) * | 2016-04-27 | 2016-09-07 | 广西农业职业技术学院 | Preparation method of Astragalus polysaccharide-iron |
| CN106234774A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose magnesium complex |
| CN106629922A (en) * | 2017-01-07 | 2017-05-10 | 内蒙古民族大学 | Organics degrading agent and preparation method thereof |
-
2017
- 2017-05-27 CN CN201710391195.0A patent/CN106995497A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328222A (en) * | 2007-06-20 | 2008-12-24 | 赵玉英 | Liquorice polyose metal complexes and preparation thereof |
| CN102351958A (en) * | 2011-08-22 | 2012-02-15 | 河南中医学院 | Preparation method and application of astragalus polysaccharide-calcium complex |
| CN104940277A (en) * | 2015-06-17 | 2015-09-30 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method of calcium astragalus polysaccharide |
| CN105924535A (en) * | 2016-04-27 | 2016-09-07 | 广西农业职业技术学院 | Preparation method of Astragalus polysaccharide-iron |
| CN106234774A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose magnesium complex |
| CN106629922A (en) * | 2017-01-07 | 2017-05-10 | 内蒙古民族大学 | Organics degrading agent and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 王雪松 等: "糖类的金属络合物", 《化学通报》 * |
| 邓毅 等: "黄芪多糖铬络合物的合成及其降血糖活性的初步研究", 《食品科学》 * |
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Effective date of registration: 20181210 Address after: 215634 No. 2 Nanjing Middle Road, Yangtze River Chemical Industrial Park, Zhangjiagang Free Trade Zone, Suzhou City, Jiangsu Province Applicant after: Zhangjiagang Weisheng Biological Pharmaceutical Co., Ltd. Address before: 215634 Building D, No. 7 Guangdong Road, Zhangjiagang Free Trade Zone, Suzhou City, Jiangsu Province, 3rd Floor Applicant before: Jiangsu Swithin Biological Medicine Engineering Research Center Co., Ltd. Applicant before: Zhangjiagang Weisheng Biological Pharmaceutical Co., Ltd. Applicant before: Wuyang lelexin Biological Medicine Co Ltd |
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