CN106994186A - The special hydrogel coupling pad of medical ultrasonic diagnostic equipment - Google Patents
The special hydrogel coupling pad of medical ultrasonic diagnostic equipment Download PDFInfo
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- CN106994186A CN106994186A CN201610045694.XA CN201610045694A CN106994186A CN 106994186 A CN106994186 A CN 106994186A CN 201610045694 A CN201610045694 A CN 201610045694A CN 106994186 A CN106994186 A CN 106994186A
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 42
- 230000008878 coupling Effects 0.000 title claims abstract description 21
- 238000010168 coupling process Methods 0.000 title claims abstract description 21
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 102000008186 Collagen Human genes 0.000 claims abstract description 9
- 108010035532 Collagen Proteins 0.000 claims abstract description 9
- 229920001436 collagen Polymers 0.000 claims abstract description 9
- 230000005855 radiation Effects 0.000 claims abstract description 9
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 6
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims abstract description 6
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims abstract description 5
- 230000008014 freezing Effects 0.000 claims abstract description 5
- 238000007710 freezing Methods 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims abstract description 5
- 238000005538 encapsulation Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 14
- 239000000523 sample Substances 0.000 claims description 13
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003384 imaging method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 239000007822 coupling agent Substances 0.000 description 4
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 241001484259 Lacuna Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000003608 radiolysis reaction Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Acoustics & Sound (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The present invention relates to supersonic diagnostic set coupling product technical field, the more particularly to special hydrogel coupling of medical ultrasonic diagnostic equipment is padded, mainly it is made up of Acritamer 940 GE, glycerine, triethanolamine, lauryl sodium sulfate, ethyl acrylate, water, the preparation method of the special hydrogel coupling pad of medical ultrasonic diagnostic equipment comprises the following steps：(1) allotment of special hydrogel stoste；(2) water-setting collagen solution carries out solid state processing；(3) freezing hydrogel pad proembryo carries out radiation treatment；(4) hydrogel pad after radiation treatment need to again be cleaned, purified；(5) examination and test of products, encapsulation, finished product are finally carried out, the beneficial effect that the technical scheme that the present invention is provided is brought is：The definition of medical supersonic imaging is greatly improved, hydrogel coupling pad is solid water gel, without toughness, will not have residue in human skin, so without paper handkerchief erasing, environmentally-friendly sanitary.
Description
Technical field
The present invention relates to supersonic diagnostic set coupling product technical field, the more particularly to special hydrogel of medical ultrasonic diagnostic equipment
Coupling pad.
Background technology
Understand why ultrasonic examination uses couplant first.Physics thinks, when ultrasonic wave is mapped to the interface of two kinds of different mediums
When upper, reflection can be produced, causes the acoustic wave energy that ultrasonic wave enters another medium to reduce.And ultrasonic wave by degree of reflection then with
The acoustic impedance index of two kinds of mediums is related, and acoustic impedance represents the ability that certain medium is hindered ultrasonic propagation.Certainly, it is different
Medium has different acoustic impedances, for physics angle, when the acoustic impedance difference of two kinds of mediums is bigger, then reflects more.
Therefore, in ultrasonic examination, if allowing ultrasonic probe directly to be contacted with patient skin, certainly exist therebetween full of air
Lacuna, equivalent to forming an interface between ultrasonic probe and air, the acoustic impedance difference larger due to existing, when ultrasonic probe hair
When the ultrasonic wave of injection advances to Air Interface, strong reflex can be produced, causes ultrasonic wave to enter people to people
In body body, it is impossible to reach the purpose of deagnostic test or treatment.
Therefore, according to this physical principle, this when can be filled in ultrasonic probe surface and skin in the urgent need to a kind of material
To exclude the interference of air between skin surface, so that ultrasonic wave smooth can pass through, and reduce the loss of sound wave as far as possible, with
Enter to greatest extent in human body, this material is exactly the medical ultrasonic coupling agent that sonographer commonly used before ultrasonic examination.When
So, except so important effect, ultrasonic coupling agent also has another effect, plays a part of lubricant, else if not having
There is it, sonographer needs to spend more strength, and the skin of patient will be by more frictionally damages.
By the analysis of above physical principle, people also just have requirement to ultrasonic coupling agent：It is required that itself and tissue acoustic impedance
Approximately equal, to reduce reflection loss；Attenuation coefficient is small, and the attenuation losses of ultrasonic wave are reduced as far as possible；In probe and patient's skin
Preferably to be filled between skin surface, thoroughly to exclude air；The long period can be kept and moist and keep in a long time
Stickiness, so as to smooth slip scanning of popping one's head in；Skin is not stimulated, infringement is not produced to skin；Easily cleaning etc..
But, doctor carry out ultrasonic examination when, it is necessary to by couplant be applied to patient need check position, use ultrasonic probe
Swept on patient skin.Due to doctor in practical operation can not uniform daubing coupling agent, the size that hand is exerted oneself during operation,
Also the thickness gap of couplant is influenceed.Thereby result in acoustic impedance unstable, it is difficult to obtain high-quality ultrasonoscopy.And couple
Agent is smeared for doctor, it is necessary on patient skin, adds Diagnostic Time, increases working doctor intensity, and patient is come
Say to be also a kind of unpleasant thing, a large amount of paper handkerchiefs are needed after ultrasonic examination to wipe the residual couplant in skin surface, are made
Into the substantial amounts of wasting of resources and forest deterioration, dirty clothing.To the patient of skin sensitivity, skin is easily stimulated.
With the development of Modern ultrasound medical science, in the urgent need to one kind is more efficient, easily ultrasonic coupling product replaces now
Couplant.
The content of the invention
In order to solve problem of the prior art, the invention provides the ultrasound that a kind of solid-state hydrogel, its perforate tissue density are produced
The acoustic impedance of wave sound impedance approximating anatomy tissue, the reflection loss, attenuation coefficient to ultrasonic wave is small, greatly improves ultrasound aobvious
The definition of picture, and without toughness, will not have residue in human skin, without paper handkerchief erasing, environmentally-friendly sanitary
Medical ultrasonic diagnostic equipment special hydrogel coupling pad.
Technical scheme of the present invention is as follows：
The special hydrogel coupling pad of medical ultrasonic diagnostic equipment, mainly by Acritamer 940 GE, glycerine, triethanolamine, dodecane
Base sodium sulphate, ethyl acrylate, water are made.
The preparation method of the special hydrogel coupling pad of medical ultrasonic diagnostic equipment comprises the following steps：
(1) allotment of special hydrogel stoste
(1) Acritamer 940 GE 6g are spread on to the about 500mL water surface, more than 24h is stood, it is fully swelled, obtain A liquid；
(2) triethanolamine 5ml, glycerine 50ml, lauryl sodium sulfate 5ml, Tween-80 5ml, ethyl acrylate 1.0g are taken
Add water about 400mL, dissolves by heating, lets cool, obtain B liquid；
(3) by B liquid it is careful, be slowly added in A liquid, add water to 1000ml, in speed be 20~30rmin with agitator﹣ 1Under, stir about 30min forms water-setting collagen solution after mixing thoroughly.
(2) water-setting collagen solution carries out solid state processing
(1) water-setting collagen solution is sub-packed in the hydrogel of various sizes of circular, the square or various ultrasonic probe shapes of thickness 7-9mm
Pad in mould.
(2) it is put into freezer and carries out low-temperature treatment, forms freezing hydrogel pad proembryo.
(3) freezing hydrogel pad proembryo carries out radiation treatment
By the hydrogel pad proembryo of cryogenic condensation, it is put into rf tank and carries out low temperature supercooled state radiation embedding treatment, because in hydrogel
Aqueous solvent or the free radical of monomer radiolysis generation be frozen at low temperature, slow down the inactivation of inducible enzyme, and dissociate after being embedded
Enzyme or concentrate on the enzyme on loose structure surface and gradually diffuse in surrounding medium, it is effectively played biological effect, after processing
The Biofunctional polymers of porous surface are obtained, its approximating anatomy organizes the water gel of acoustic impedance.Make original hydrogel proembryo,
Density reaches the degree intended like tissue, and strengthens the toughness of its product, hydrogel pad is not easily broken in use.
(4) clean, purify
Hydrogel pad after radiation treatment need to again be cleaned, purified.
(5) examine
Finally carry out the examination and test of products, encapsulation, finished product.
The beneficial effect that the technical scheme that the present invention is provided is brought is：
The ultrasonoscopy of subject hydrogel coupling pad has great raising than traditional couplant definition；It makes ultrasonic probe can
Drive hydrogel coupling pad to be slided on patient skin, preferably eliminate skin surface air, hydrogel coupling pad and patient skin
Between the moisture film that is formed have good greasy property；Hydrogel pad is nontoxic to human body, not damaged corrosion-free to ultrasonic probe.
Due to isolating between ultrasonic probe and patient skin, without periodically being sterilized to ultrasonic probe.Effectively prevent friendship between patient
Fork infection.Hydrogel coupling pad is solid gel shape, without toughness, will not have residue in human skin, so
Without paper handkerchief erasing, environmentally-friendly sanitary.
The scope that hydrogel coupling pad can be used is more extensive：Used in operation, the position of invasive wound, crinite position
It can check.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, what is used required in being described below to embodiment is attached
Figure is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for this area
For those of ordinary skill, on the premise of not paying creative work, other accompanying drawings can also be obtained according to these accompanying drawings.
The process chart of Fig. 1 present invention.
Fig. 2 products of the present invention and common couplant product image effect comparison diagram.
Fig. 3 products of the present invention and common couplant product image effect comparison diagram.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, further detailed is made to embodiment of the present invention below
Description.
The special hydrogel coupling pad of medical ultrasonic diagnostic equipment, mainly by Acritamer 940 GE, glycerine, triethanolamine, dodecane
Base sodium sulphate, ethyl acrylate, water are made.
As shown in figure 1, the preparation method of the special hydrogel coupling pad of medical ultrasonic diagnostic equipment comprises the following steps：
1. Acritamer 940 GE 6g to be spread on to the about 500mL water surface first in A batch cans, more than 24h is stood, makes its abundant
It is swelled, obtains A liquid；
2. and then triethanolamine 5ml, glycerine 50ml, lauryl sodium sulfate 5ml, Tween-80 5ml, third are taken in B batch cans
Olefin(e) acid ethyl ester 1.0g adds water about 400mL, heating for dissolving, lets cool, obtains B liquid；
3. will be squeezed into A liquid with liquid pump in reactor, then by B liquid it is careful, be slowly added in A liquid, add water to full dose, use
Reactor agitator low speed (20~30rmin-1), stir about 30min forms water-setting collagen solution after mixing thoroughly；
4. water-setting collagen solution is sub-packed in the hydrogel pad of various sizes of circular, the square or various ultrasonic probe shapes of thickness 7-9mm
In mould, it is put into freezer and carries out low-temperature treatment, form hydrogel pad proembryo；
5. by the hydrogel pad proembryo of cryogenic condensation, being removed from the molds and being put into rf tank, carry out at the radiation embedding of low temperature supercooled state
Reason, obtains the water gel that approximating anatomy organizes acoustic impedance after processing；
6. the finished product hydrogel pad after processing need to again be cleaned, purified；
7. finally carry out the examination and test of products, encapsulation, finished product.
As Figure 2-3, finished product of the present invention and common couplant product are subjected to image check with regard to same target, find the present invention
Finished product striograph is apparent.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the spirit and principles in the present invention it
Interior, any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (2)
1. the special hydrogel coupling pad of medical ultrasonic diagnostic equipment, it is characterised in that mainly by Acritamer 940 GE, glycerine, three
Monoethanolamine, lauryl sodium sulfate, ethyl acrylate, water are made.
2. the special hydrogel coupling pad of medical ultrasonic diagnostic equipment according to claim 1, it is characterised in that preparation method bag
Include following steps：
(1) allotment of special hydrogel stoste
(1) Acritamer 940 GE 6g are spread on to the about 500mL water surface, more than 24h is stood, it is fully swelled, obtain A liquid；
(2) triethanolamine 5ml, glycerine 50ml, lauryl sodium sulfate 5ml, Tween-80 5ml, ethyl acrylate 1.0g are taken
Add water about 400mL, dissolves by heating, lets cool, obtain B liquid；
(3) by B liquid it is careful, be slowly added in A liquid, add water to 1000ml, in speed be 20~30rmin with agitator﹣Under 1, stir about 30min forms water-setting collagen solution after mixing thoroughly；
(2) water-setting collagen solution carries out solid state processing
(1) water-setting collagen solution is sub-packed in the hydrogel of various sizes of circular, the square or various ultrasonic probe shapes of thickness 7-9mm
Pad in mould；
(2) it is put into freezer and carries out low-temperature treatment, forms freezing hydrogel pad proembryo；
(3) freezing hydrogel pad proembryo carries out radiation treatment
By the hydrogel pad proembryo of cryogenic condensation, it is put into rf tank and carries out low temperature supercooled state radiation embedding treatment；
(4) clean, purify
Hydrogel pad after radiation treatment need to again be cleaned, purified；
(5) examine
Finally carry out the examination and test of products, encapsulation, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610045694.XA CN106994186A (en) | 2016-01-23 | 2016-01-23 | The special hydrogel coupling pad of medical ultrasonic diagnostic equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610045694.XA CN106994186A (en) | 2016-01-23 | 2016-01-23 | The special hydrogel coupling pad of medical ultrasonic diagnostic equipment |
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| Publication Number | Publication Date |
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| CN106994186A true CN106994186A (en) | 2017-08-01 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610045694.XA Pending CN106994186A (en) | 2016-01-23 | 2016-01-23 | The special hydrogel coupling pad of medical ultrasonic diagnostic equipment |
Country Status (1)
| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456117A (en) * | 2014-04-24 | 2017-02-22 | 索诺法斯特股份公司 | Conductive medium pad for ultrasound probe |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010027349A1 (en) * | 2008-09-03 | 2010-03-11 | Transdermal Innovations Inc. | Multipurpose hydrogel compositions and products |
| CN105056257A (en) * | 2015-09-09 | 2015-11-18 | 青岛明药堂医疗股份有限公司 | Method for preparing medicinal ultrasonic coupled patch |
-
2016
- 2016-01-23 CN CN201610045694.XA patent/CN106994186A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010027349A1 (en) * | 2008-09-03 | 2010-03-11 | Transdermal Innovations Inc. | Multipurpose hydrogel compositions and products |
| CN105056257A (en) * | 2015-09-09 | 2015-11-18 | 青岛明药堂医疗股份有限公司 | Method for preparing medicinal ultrasonic coupled patch |
Non-Patent Citations (2)
| Title |
|---|
| 张龙等: "《绿色化学》", 31 August 2014, 华中科技大学出版社 * |
| 李捷玮等: "《常用药物辅料手册》", 30 June 2000, 第二军医大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106456117A (en) * | 2014-04-24 | 2017-02-22 | 索诺法斯特股份公司 | Conductive medium pad for ultrasound probe |
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Application publication date: 20170801 |