CN106986918A - Based on monolithic processor controlled laboratory level protein chromatography system - Google Patents
Based on monolithic processor controlled laboratory level protein chromatography system Download PDFInfo
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- CN106986918A CN106986918A CN201710414306.5A CN201710414306A CN106986918A CN 106986918 A CN106986918 A CN 106986918A CN 201710414306 A CN201710414306 A CN 201710414306A CN 106986918 A CN106986918 A CN 106986918A
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- valve
- pumps
- pressure sensor
- mcu control
- position selector
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses based on monolithic processor controlled laboratory level protein chromatography system, including MCU control mainboards, MCU control mainboards respectively with telecontrol equipment, detection means, display operating device, collection device is connected with communicator, telecontrol equipment includes the A pumps for being connected to entrance sluice valve, B pumps, sampling valve, on, lower valve and cleaning pump, detection means includes system pressure sensor, before post, pressure sensor after post, collection device includes collecting valve and collector, A pumps and B pumps are connected with same blender, blender connects sampling valve, blender is provided with system pressure sensor with sampling valve, inlet valve connection upper prop position selector valve, on, lower prop position selector valve is connected with chromatographic column, pressure sensor is connected with lower prop position selector valve and monitoring device, monitoring device is connected with display operating device and MCU control mainboards, valve is collected in the control of MCU control mainboards.The present invention is simple in construction, reasonable in design, it is adaptable to laboratory, and operation is more flexible, and cost is low.
Description
Technical field
It is specifically a kind of based on monolithic processor controlled laboratory level protein chromatographic the present invention relates to protein chromatography techniques
System.
Background technology
The protein chromatography system of traditional industrial production level is often bulky, due to PLC itself strong antijamming capabilities, therefore
The low advantage of barrier rate, generally using master controllers of the PLC as protein chromatography system, but for the protein chromatographic of laboratory level
System, with specific use occasion, pump, valve to some specific protocols, it is impossible to be controlled using PLC are used with PLC
Just become expensive as master controller and flexibility is not high.
The content of the invention
In order to solve the above problems the invention provides one kind with small, more flexible with laboratory floor space, while cost
Relatively low monolithic processor controlled laboratory level protein chromatography system.
The present invention is realized by above technical scheme in order to achieve the above object：
The present invention is based on monolithic processor controlled laboratory level protein chromatography system, including MCU control mainboards, MCU control mainboards
It is connected respectively with telecontrol equipment, detection means, display operating device, collection device and communicator, telecontrol equipment includes difference
It is connected with the A pumps, B pumps, sampling valve of entrance sluice valve 1（5）, upper prop position selector valve（7）, lower prop position selector valve（8）And cleaning pump,
Detection means includes before system pressure sensor, post pressure sensor after pressure sensor, post, collection device include collecting valve and
Collector, A pumps and B pumps are connected with same blender, and blender is connected with sampling valve by pipeline, in blender and sampling valve
Between pipeline on be provided with system pressure sensor, inlet valve is connected with upper prop position selector valve, upper prop position by feed pipe
Selector valve is connected with the feeding port of several chromatographic columns, and the discharging opening of several chromatographic columns is both connected on the selector valve of lower prop position, lower prop
Position selector valve is connected with pressure sensor after post, and pressure sensor is connected with monitoring device after post, and monitoring device is operated with display
Device is connected with MCU control mainboards, and valve is collected in the control of MCU control mainboards, collects valve and is connected with collector and slag-draining device.
Further improvement of the present invention is：The entrance sluice valve 1 of connection A pumps is connected with A1、A2、A3、A4、A5、A6Charging
Pipeline, the entrance sluice valve 1 of connection B pumps is connected with B1、B2、B3、B4、B5、B6Feed pipe.
Further improvement of the present invention is：Sampling valve is connected with feed pipe, quantitative loop, system waste pipe and loading waste discharge
Pipe.
Further improvement of the present invention is：Cleaning pump is connected by pipeline with A pumps and B pumps.
Further improvement of the present invention is：Monitoring device includes UV-detector, capacitor and PH monitors.
Further improvement of the present invention is：MCU control mainboards are led to by communication control module to the movement of operating personnel
Interrogate equipment and send signal.
The beneficial effects of the invention are as follows：Sample liquid is pumped into blender by MCU control mainboards control control A pumps and B pumps
The sample liquid amount into feed pipe is controlled by sampling valve after being sufficiently mixed, sample liquid entered the selector valve control of upper prop position and enters every
Sample liquid amount in individual chromatographic column, lower prop position selector valve control sample liquid discharge rate, MCU control mainboards control entrance sluice valve 1, sample introduction
Valve, upper prop position selector valve, lower prop position selector valve and collection valve, detection means and monitoring device are carried out during being chromatographed to sample liquid
The monitoring of detection, monitoring device is mainly UV-detector, capacitor and PH detectors, and ultraviolet detector can detect chromatography
Sample liquid afterwards obtains ultraviolet radiation absorption value, and PH detectors are the acid-base values for detecting sample liquid, and the numerical value of monitoring device measurement reaches
Valve is collected in the control of MCU control mainboards after the standard of customer requirement and collector is collected sample liquid, and slag-draining device is not to meeting mark
Accurate sample liquid is collected, and sample collection well by communication module into the mobile device of operating personnel sent out by rear MCU control mainboards
The number of delivering letters, system is more flexible, and floor space is small.
The present invention is simple in construction, reasonable in design, it is adaptable to laboratory, and operation is more flexible, and floor space is small, while cost
It is low.
Brief description of the drawings
Fig. 1 is the functional schematic of the present invention.
Fig. 2 is connection diagram of the present invention.
Wherein：1- entrance sluice valves, 2-A pumps, 3- B pumps, 4- blenders, 5- sampling valves, 6- system pressure sensors, 7-
Pressure sensor after pressure sensor before upper prop position selector valve, 8- lower props position selector valve, 9- posts, 10- posts, 11- monitoring devices,
12- display operating devices, 13- collects valve, 14- collectors.
Embodiment
In order to strengthen the understanding of the present invention, present invention work is further retouched in detail below in conjunction with drawings and examples
State, the embodiment is only used for explaining the present invention, protection scope of the present invention is not constituted and limited.
As shown in Figure 1-2, the present invention is based on monolithic processor controlled laboratory level protein chromatography system, including MCU controls
Mainboard, MCU control mainboards are connected with telecontrol equipment, detection means, display operating device, collection device and communicator respectively,
Telecontrol equipment includes the A pumps 2, B pumps 3, sampling valve for being connected to entrance sluice valve 1（5）, upper prop position selector valve（7）, lower prop position
Selector valve（8）And cleaning pump, detection means includes before system pressure sensor, post pressure sensor after pressure sensor 9, post
10, collection device includes collecting valve and collector, and A pumps 2 and B pumps 3 are connected with same blender 4, and blender 4 is connected by pipeline
Sampling valve 5 is connected to, system pressure sensor 6 is provided with the pipeline between blender 4 and sampling valve 5, sampling valve 5 is by entering
Pipe material is connected with upper prop position selector valve 7, and upper prop position selector valve 7 is connected with the feeding port of several chromatographic columns, several chromatographic columns
Discharging opening is both connected on the selector valve 8 of lower prop position, and lower prop position selector valve 8 is connected with pressure sensor after post 10, and pressure is passed after post
Sensor 10 is connected with monitoring device 11, and monitoring device 11 is connected with display operating device 12 and MCU control mainboards, MCU control masters
Valve 13 is collected in plate control, is collected valve 13 and is connected with collector 14 and slag-draining device, the entrance sluice valve 1 of connection A pumps 2 is connected with
A1、A2、A3、A4、A5、A6Feed pipe, the entrance sluice valve 1 of connection B pumps 3 is connected with B1、B2、B3、B4、B5、B6Feed pipe, enters
Sample valve 5 is connected with feed pipe, quantitative loop, system waste pipe and loading waste pipe, and cleaning pump passes through pipeline and A pumps 2 and the phase of B pumps 3
Even, A pumps 2 and B pumps 3 are cleaned, cleaning pump is connected with cleaning fluid, are pumped into cleaning fluid out of A pumps and B pumps by cleaning pump
Whole tomographic system, is cleaned, it is to avoid bacteria breed to whole system and pipeline, monitoring device 11 including UV-detector,
Capacitor and PH detectors, the numerical value detected by monitoring device need to meet numerical value as defined in client, in detection means detection
After being matched to numerical value with the numerical value set, valve is collected in the control of MCU control mainboards and collector is collected, MCU control mainboards
Signal is sent to the mobile communication equipment of operating personnel by communication control module, it is not necessary to which operating personnel's moment pays close attention to display behaviour
Make device and collector.
The present invention is simple in construction, reasonable in design, it is adaptable to laboratory, and operation is more flexible, and floor space is small, while cost
It is low.
Claims (6)
1. based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：Including MCU control mainboards, the MCU
Control mainboard is connected with telecontrol equipment, detection means, display operating device, collection device and communicator respectively, the motion
Device includes being connected to entrance sluice valve（1）A pumps（2）, B pumps（3）, sampling valve（5）, upper prop position selector valve（7）, lower prop
Position selector valve（8）And cleaning pump, the detection means include system pressure sensor, post before pressure sensor（9）, pressure after post
Sensor（10）, the collection device is including collecting valve and collector, the A pumps（2）With B pumps（3）With same blender（4）
It is connected, the blender（4）Sampling valve is connected with by pipeline（5）, in the blender（4）With the sampling valve（5）Between
Pipeline on be provided with system pressure sensor（6）, the sampling valve（5）Upper prop position selector valve is connected with by feed pipe
（7）, upper prop position selector valve（7）It is connected with the feeding port of several chromatographic columns, the discharging opening of several chromatographic columns is all connected with
In lower prop position selector valve（8）On, lower prop position selector valve（8）With pressure sensor after the post（10）It is connected, it is described
Pressure sensor after post（10）With the monitoring device（11）It is connected, the monitoring device（11）With the display operating device
（12）It is connected with MCU control mainboards, the MCU control mainboards control the collection valve（13）, the collection valve（13）It is connected with
Collector（14）And slag-draining device.
2. according to claim 1 based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：Connection institute
State A pumps（2）The entrance sluice valve（1）It is connected with A1、A2、A3、A4、A5、A6Feed pipe, connects the B pumps（3）It is described
Entrance sluice valve（1）It is connected with B1、B2、B3、B4、B5、B6Feed pipe.
3. according to claim 1 based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：It is described enter
Sample valve（5）It is connected with feed pipe, quantitative loop, system waste pipe and loading waste pipe.
4. according to claim 1 based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：It is described clear
Wash pump and pass through pipeline and the A pumps（2）With B pumps（3）It is connected.
5. according to claim 1 based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：The prison
Survey device（11）Including UV-detector, capacitor and PH detectors.
6. according to claim 1 based on monolithic processor controlled laboratory level protein chromatography system, it is characterised in that：It is described
MCU control mainboards send signal by communication control module to the mobile communication equipment of operating personnel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710414306.5A CN106986918A (en) | 2017-06-05 | 2017-06-05 | Based on monolithic processor controlled laboratory level protein chromatography system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710414306.5A CN106986918A (en) | 2017-06-05 | 2017-06-05 | Based on monolithic processor controlled laboratory level protein chromatography system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106986918A true CN106986918A (en) | 2017-07-28 |
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ID=59421899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710414306.5A Pending CN106986918A (en) | 2017-06-05 | 2017-06-05 | Based on monolithic processor controlled laboratory level protein chromatography system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109634164A (en) * | 2018-11-09 | 2019-04-16 | 苏州赛谱仪器有限公司 | Protein chromatographic control system |
| CN113499608A (en) * | 2021-06-29 | 2021-10-15 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201161989Y (en) * | 2007-08-14 | 2008-12-10 | 百奇生物科技(上海)有限公司 | Multicenter protein compatible chromatography purification instrument |
| CN102190704A (en) * | 2010-03-17 | 2011-09-21 | 中国科学院过程工程研究所 | Protein chromatography system |
| CN204469275U (en) * | 2013-12-18 | 2015-07-15 | 源创精科生物科技(长沙)有限公司 | The full-automatic tomographic system of a kind of list/double pump |
-
2017
- 2017-06-05 CN CN201710414306.5A patent/CN106986918A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201161989Y (en) * | 2007-08-14 | 2008-12-10 | 百奇生物科技(上海)有限公司 | Multicenter protein compatible chromatography purification instrument |
| CN102190704A (en) * | 2010-03-17 | 2011-09-21 | 中国科学院过程工程研究所 | Protein chromatography system |
| CN204469275U (en) * | 2013-12-18 | 2015-07-15 | 源创精科生物科技(长沙)有限公司 | The full-automatic tomographic system of a kind of list/double pump |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109634164A (en) * | 2018-11-09 | 2019-04-16 | 苏州赛谱仪器有限公司 | Protein chromatographic control system |
| CN113499608A (en) * | 2021-06-29 | 2021-10-15 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
| CN113499608B (en) * | 2021-06-29 | 2022-04-08 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
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